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Summaries & Associations of Study Results

TR-430 C.I. Direct Blue 218

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Target Organs and Levels of Evidence
NTP Technical Report Number 430

Produced from Chemtrack Database 09/19/01

CHEMICAL/ CAS NUMBER PEER REVIEW DATE PRIMARY USES ROUTE/EXPOSURE LEVELS STUDY LABORATORY
C.I. DIRECT BLUE 218
28407-37-6 		12/01/92 DYE FOR CELLULOSE, ACETATE, NYLON, SILK, WOOL, TISSUE AND FINE PAPERS. (TDB) Dosed-Feed R&M: 0, 1000, 3000, 10000 PPM/60 PER GROUP Microbiological Associates
LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM):
MR: SOME EVIDENCE ORAL CAVITY: SQUAMOUS CELL PAPILLOMA 0/50 0/50 0/50 5/51; SQUAMOUS CELL CARCINOMA 0/50 0/50 0/50 1/51; BASOSQUAMOUS TUMOR BENIGN 0/50 0/50 0/50 1/51
MAY HAVE BEEN RELATED: FORESTOMACH: SQUAMOUS CELL PAPILLOMA 0/50 0/50 2/50 1/50; SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 0/50
NON-NEOPLASTIC LESIONS: FORESTOMACH: BASAL CELL HYPERPLASIA
FR: NO EVIDENCE
NON-NEOPLASTIC LESIONS: FORESTOMACH: BASAL CELL HYPERPLASIA
MM: CLEAR EVIDENCE LIVER: ADENOMA 16/50 19/50 17/50 40/50; CARCINOMA 7/50 3/50 8/50 17/50
MAY HAVE BEEN RELATED: KIDNEY TUBULAR CELL: ADENOMA 0/50 2/50 1/50 1/50 OR CARCINOMA 0/50 1/50 0/50 0/50 COMBINED 0/50 3/50 1/50 1/50
INTESTINES: CARCINOMA 1/50 0/50 0/50 3/50
NON-NEOPLASTIC LESIONS: LIVER: BASOPHILIC FOCI; EOSINOPHILIC FOCI
FM: CLEAR EVIDENCE LIVER: ADENOMA 7/49 12/50 17/49 41/49; CARCINOMA 5/49 5/50 6/49 12/49
NON-NEOPLASTIC LESIONS: LIVER: BASOPHILIC FOCI; CLEAR CELL FOCI; EOSINOPHILIC FOCI

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