The Cancer Prevention Faculty combines scientific strategies (i.e., combining cancer vaccines and chemoprevention) with proof-of-principle studies and cooperatively develops novel approaches and technologies. Our goals include:
1) Demonstrating genes whose expression causes, prevents, or modifies susceptibility to carcinogenesis, at any stage of progression in any organ, using transgenic or targeted mouse models.
2) Demonstrating, using suitable mouse models, that "hitting" the molecular target is effective for preventing progression without producing unacceptable side effects in the host.
3) Identifying small molecule drugs or dietary interventions, vaccines, or gene therapy reagents that modulate expression or activity of validated molecular targets.
4) Designing preclinical experiments to address the pharmacokinetic and pharmacodynamic effects of potential preventive agents.
5) Creating animal experiments to evaluate the effects of interventions on molecular targets, early biomarkers, and cancer endpoints.
6) Planning human intervention studies to test the efficacy of single or combined interventions in modulating early biomarkers, cancer incidence, or progression.
|
 |
