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Our Science – KewalRamani Website

Vineet N. KewalRamani, Ph.D.

Selected Publications
1)  Michel N, Goffinet C, Ganter K, Allespach I, Kewalramani VN, Saifuddin M, Littman DR, Greene WC, Goldsmith MA, Keppler OT.
Human cyclin T1 expression ameliorates a T-cell-specific transcriptional limitation for HIV in transgenic rats, but is not sufficient for a spreading infection of prototypic R5 HIV-1 strains ex vivo.
Retrovirology. 6: 2, 2009. [Journal]
2)  Ambrose Z, Compton L, Piatak M, Lu D, Alvord WG, Lubomirski MS, Hildreth JE, Lifson JD, Miller CJ, KewalRamani VN.
Incomplete protection against simian immunodeficiency virus vaginal transmission in rhesus macaques by a topical antiviral agent revealed by repeat challenges.
J. Virol. 82: 6591-9, 2008. [Journal]
3)  Ambrose Z, KewalRamani V.
Of mice and monkeys: New advances in animal models to study HIV-1 therapy and prophylaxis.
Future HIV Ther. 2: 363-373, 2008. Full Text Article. [Journal]
4)  Mulky A, Cohen TV, Kozlov SV, Korbei B, Foisner R, Stewart CL, KewalRamani VN.
The LEM domain proteins emerin and LAP2alpha are dispensable for human immunodeficiency virus type 1 and murine leukemia virus infections.
J. Virol. 82: 5860-8, 2008. [Journal]
5)  Ambrose Z, Palmer S, Boltz VF, Kearney M, Larsen K, Polacino P, Flanary L, Oswald K, Piatak M, Smedley J, Shao W, Bischofberger N, Maldarelli F, Kimata JT, Mellors JW, Hu SL, Coffin JM, Lifson JD, KewalRamani VN.
Suppression of viremia and evolution of human immunodeficiency virus type 1 drug resistance in a macaque model for antiretroviral therapy.
J. Virol. 81: 12145-55, 2007. [Journal]
6)  Ambrose Z, Kewalramani VN, Bieniasz PD, Hatziioannou T.
HIV/AIDS: in search of an animal model.
Trends Biotechnol. 25: 333-7, 2007. [Journal]
7)  Wang JH, Janas AM, Olson WJ, KewalRamani VN, Wu L.
CD4 coexpression regulates DC-SIGN-mediated transmission of human immunodeficiency virus type 1.
J. Virol. 81: 2497-507, 2007. [Journal]
8)  Wu L, KewalRamani VN.
Dendritic-cell interactions with HIV: infection and viral dissemination.
Nat. Rev. Immunol. 6: 859-68, 2006. [Journal]
9)  Ambrose Z, Julias JG, Boyer PL, Kewalramani VN, Hughes SH.
The Level of Reverse Transcriptase (RT) in Human Immunodeficiency Virus Type 1 Particles Affects Susceptibility to Nonnucleoside RT Inhibitors but Not to Lamivudine.
J Virol. 80: 2578-81, 2006. [Journal]
10)  Sun J, Soos T, Kewalramani VN, Osiecki K, Zheng JH, Falkin L, Santambrogio L, Littman DR, Goldstein H.
CD4-specific transgenic expression of human cyclin T1 markedly increases human immunodeficiency virus type 1 (HIV-1) production by CD4+ T lymphocytes and myeloid cells in mice transgenic for a provirus encoding a monocyte-tropic HIV-1 isolate.
J. Virol. 80: 1850-62, 2006. [Journal]
11)  García-Piñeres AJ, Hildesheim A, Trivett M, Williams M, Wu L, Kewalramani VN, Pinto LA.
Role of DC-SIGN in the activation of dendritic cells by HPV-16 L1 virus-like particle vaccine.
Eur. J. Immunol. 36: 437-45, 2006. [Journal]
12)  VanCompernolle SE, Taylor RJ, Oswald-Richter K, Jiang J, Youree BE, Bowie JH, Tyler MJ, Conlon JM, Wade D, Aiken C, Dermody TS, KewalRamani VN, Rollins-Smith LA, Unutmaz D.
Antimicrobial peptides from amphibian skin potently inhibit human immunodeficiency virus infection and transfer of virus from dendritic cells to T cells.
J Virol. 79: 11598-606, 2005. [Journal]
13)  Ambrose Z, Boltz V, Palmer S, Coffin JM, Hughes SH, Kewalramani VN.
In vitro characterization of a simian immunodeficiency virus-human immunodeficiency virus (HIV) chimera expressing HIV type 1 reverse transcriptase to study antiviral resistance in pigtail macaques.
J Virol. 78: 13553-61, 2004. [Journal]
14)  Baumann JG, Unutmaz D, Miller MD, Breun SK, Grill SM, Mirro J, Littman DR, Rein A, KewalRamani VN.
Murine T cells potently restrict human immunodeficiency virus infection.
J Virol. 78: 12537-47, 2004. [Journal]
15)  Lee K, KewalRamani VN.
From the Cover: In defense of the cell: TRIM5{alpha} interception of mammalian retroviruses.
Proc Natl Acad Sci U S A. 101: 10496-10497, 2004. [Journal]
16)  Wu L, Martin TD, Han YC, Breun SK, KewalRamani VN.
Trans-dominant cellular inhibition of DC-SIGN-mediated HIV-1 transmission.
Retrovirology. 1: 14, 2004. [Journal]
17)  Wu L, Martin TD, Carrington M, KewalRamani VN.
Raji B cells, misidentified as THP-1 cells, stimulate DC-SIGN-mediated HIV transmission.
Virology. 318: 17-23, 2004. [Journal]
18)  McDonald D, Wu L, Bohks SM, KewalRamani VN, Unutmaz D, Hope TJ.
Recruitment of HIV and its receptors to dendritic cell-T cell junctions.
Science. 300: 1295-7, 2003. [Journal]
19)  KewalRamani VN, Coffin JM.
Weapons of mutational destruction.
Science. 301: 923-925, 2003. [Journal]
20)  Wu L, Bashirova AA, Martin TD, Villamide L, Mehlhop E, Chertov AO, Unutmaz D, Pope M, Carrington M, KewalRamani VN.
Rhesus macaque dendritic cells efficiently transmit primate lentiviruses independently of DC-SIGN.
Proc Natl Acad Sci U S A. 99: 1568-73, 2002. [Journal]
21)  Gummuluru S, KewalRamani VN, Emerman M.
Dendritic cell-mediated viral transfer to T cells is required for human immunodeficiency virus type 1 persistence in the face of rapid cell turnover.
J Virol. 76: 10692-701, 2002. [Journal]
22)  Wu L, Martin TD, Vazeux R, Unutmaz D, KewalRamani VN.
Functional evaluation of DC-SIGN monoclonal antibodies reveals DC-SIGN interactions with ICAM-3 do not promote human immunodeficiency virus type 1 transmission.
J Virol. 76: 5905-14, 2002. [Journal]
23)  Bashirova AA, Geijtenbeek TB, van Duijnhoven GC, van Vliet SJ, Eilering JB, Martin MP, Wu L, Martin TD, Viebig N, Knolle PA, KewalRamani VN, van Kooyk Y, Carrington M.
A dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN)-related protein is highly expressed on human liver sinusoidal endothelial cells and promotes HIV-1 infection.
J Exp Med. 193: 671-8, 2001. [Journal]
24)  Browning CM, Smith MJ, Clark NM, Lane BR, Parada C, Montano M, KewalRamani VN, Littman DR, Essex M, Roeder RG, Markovitz DM.
Human GLI-2 is a tat activation response element-independent Tat cofactor.
J Virol. 75: 2314-23, 2001. [Journal]
25)  Geijtenbeek TB, Kwon DS, Torensma R, van Vliet SJ, van Duijnhoven GC, Middel J, Cornelissen IL, Nottet HS, KewalRamani VN, Littman DR, Figdor CG, van Kooyk Y.
DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells.
Cell. 100: 587-97, 2000. [Journal]

This page was last updated on 1/30/2009.