| | This journal provides immediate access to some articles. Commentaries Cyclooxygenase 2-derived prostaglandin E2 regulates the angiogenic switch Dingzhi Wang and Raymond N. DuBois Proc Natl Acad Sci U S A. 2004 January 13; 101(2): 415–416. Published online 2004 January 5. doi: 10.1073/pnas.0307640100.PMCID: PMC327160 A myristoyl switch regulates membrane binding of HIV-1 Gag Marilyn D. Resh Proc Natl Acad Sci U S A. 2004 January 13; 101(2): 417–418. Published online 2004 January 5. doi: 10.1073/pnas.0308043101.PMCID: PMC327161 Physical Sciences Chemistry H-bonded N-heterocyclic base-pair phototautomerizational potential barrier and mechanism: The 7-azaindole dimer J. Catalán, P. Pérez, J. C. del Valle, J. L. G. de Paz, and M. Kasha Proc Natl Acad Sci U S A. 2004 January 13; 101(2): 419–422. Published online 2003 December 30. doi: 10.1073/pnas.0306721101.PMCID: PMC327162 Geophysics Soot climate forcing via snow and ice albedos James Hansen and Larissa Nazarenko Proc Natl Acad Sci U S A. 2004 January 13; 101(2): 423–428. Published online 2003 December 29. doi: 10.1073/pnas.2237157100.PMCID: PMC327163 Physics Organic light-emitting diodes formed by soft contact lamination Tae-Woo Lee, Jana Zaumseil, Zhenan Bao, Julia W. P. Hsu, and John A. Rogers Proc Natl Acad Sci U S A. 2004 January 13; 101(2): 429–433. Published online 2004 January 2. doi: 10.1073/pnas.0304179101.PMCID: PMC327164 Biological Sciences Biochemistry Identification of Lhp1p-associated RNAs by microarray analysis in Saccharomyces cerevisiae reveals association with coding and noncoding RNAs Maki Inada and Christine Guthrie Proc Natl Acad Sci U S A. 2004 January 13; 101(2): 434–439. Published online 2004 January 2. doi: 10.1073/pnas.0307425100.PMCID: PMC327165 The second extracellular loop of the dopamine D2 receptor lines the binding-site crevice Lei Shi and Jonathan A. Javitch Proc Natl Acad Sci U S A. 2004 January 13; 101(2): 440–445. Published online 2004 January 2. doi: 10.1073/pnas.2237265100.PMCID: PMC327166 A functional Ni-Ni-[4Fe-4S] cluster in the monomeric acetyl-CoA synthase from Carboxydothermus hydrogenoformans Vitali Svetlitchnyi, Holger Dobbek, Wolfram Meyer-Klaucke, Thomas Meins, Bärbel Thiele, Piero Römer, Robert Huber, and Ortwin Meyer Proc Natl Acad Sci U S A. 2004 January 13; 101(2): 446–451. Published online 2003 December 29. doi: 10.1073/pnas.0304262101.PMCID: PMC327167 Bacillus subtilis RecU protein cleaves Holliday junctions and anneals single-stranded DNA Silvia Ayora, Begoña Carrasco, Ernesto Doncel, Rudi Lurz, and Juan C. Alonso Proc Natl Acad Sci U S A. 2004 January 13; 101(2): 452–457. Published online 2003 December 30. doi: 10.1073/pnas.2533829100.PMCID: PMC327168 Myc-interacting protein 1 target gene profile: A link to microtubules, extracellular signal-regulated kinase, and cell growth Joseph Ziegelbauer, Joyce Wei, and Robert Tjian Proc Natl Acad Sci U S A. 2004 January 13; 101(2): 458–463. Published online 2004 January 2. doi: 10.1073/pnas.0307562100.PMCID: PMC327169 Physical and functional interaction of androgen receptor with calmodulin in prostate cancer cells Eugenia Cifuentes, Jennifer M. Mataraza, Barbara A. Yoshida, Mani Menon, David B. Sacks, Evelyn R. Barrack, and G. Prem-Veer Reddy Proc Natl Acad Sci U S A. 2004 January 13; 101(2): 464–469. Published online 2003 December 26. doi: 10.1073/pnas.0307161101.PMCID: PMC327170 From the Cover: A proteomic approach for the analysis of instantly released wound and immune proteins in Drosophila melanogaster hemolymph Evy Vierstraete, Peter Verleyen, Geert Baggerman, Wannes D'Hertog, Gert Van den Bergh, Lutgarde Arckens, Arnold De Loof, and Liliane Schoofs Proc Natl Acad Sci U S A. 2004 January 13; 101(2): 470–475. Published online 2004 January 5. doi: 10.1073/pnas.0304567101.PMCID: PMC327171 Context-dependent regulation of GATA-1 by friend of GATA-1 Danielle L. Letting, Ying-Yu Chen, Carrie Rakowski, Sarah Reedy, and Gerd A. Blobel Proc Natl Acad Sci U S A. 2004 January 13; 101(2): 476–481. Published online 2003 December 26. doi: 10.1073/pnas.0306315101.PMCID: PMC327172 Directed evolution of mammalian paraoxonases PON1 and PON3 for bacterial expression and catalytic specialization Amir Aharoni, Leonid Gaidukov, Shai Yagur, Lilly Toker, Israel Silman, and Dan S. Tawfik Proc Natl Acad Sci U S A. 2004 January 13; 101(2): 482–487. Published online 2003 December 26. doi: 10.1073/pnas.2536901100.PMCID: PMC327173 From the Cover: Analysis of C5a-mediated chemotaxis by lentiviral delivery of small interfering RNA Jong-Ik Hwang, Iain D. C. Fraser, Sangdun Choi, Xiao-Feng Qin, and Melvin I. Simon Proc Natl Acad Sci U S A. 2004 January 13; 101(2): 488–493. Published online 2003 December 29. doi: 10.1073/pnas.0307549100.PMCID: PMC327174 Availability of specific reductases controls the temporal activity of the cytochrome P450 complement of Streptomyces coelicolor A3(2) Li Lei, Michael R. Waterman, Armand J. Fulco, Steven L. Kelly, and David C. Lamb Proc Natl Acad Sci U S A. 2004 January 13; 101(2): 494–499. Published online 2004 January 2. doi: 10.1073/pnas.2435922100.PMCID: PMC327175 Demonstration of mammalian protein O-mannosyltransferase activity: Coexpression of POMT1 and POMT2 required for enzymatic activity Hiroshi Manya, Atsuro Chiba, Aruto Yoshida, Xiaohui Wang, Yasunori Chiba, Yoshifumi Jigami, Richard U. Margolis, and Tamao Endo Proc Natl Acad Sci U S A. 2004 January 13; 101(2): 500–505. Published online 2003 December 29. doi: 10.1073/pnas.0307228101.PMCID: PMC327176 Biophysics The origin of vibrational mode couplings in various secondary structural motifs of polypeptides Andrew Moran and Shaul Mukamel Proc Natl Acad Sci U S A. 2004 January 13; 101(2): 506–510. Published online 2004 January 2. doi: 10.1073/pnas.2533089100.PMCID: PMC327177 Protein topology determines binding mechanism Yaakov Levy, Peter G. Wolynes, and José N. Onuchic Proc Natl Acad Sci U S A. 2004 January 13; 101(2): 511–516. Published online 2003 December 23. doi: 10.1073/pnas.2534828100.PMCID: PMC327178 From the Cover: Entropic switch regulates myristate exposure in the HIV-1 matrix protein Chun Tang, Erin Loeliger, Paz Luncsford, Isaac Kinde, Dorothy Beckett, and Michael F. Summers Proc Natl Acad Sci U S A. 2004 January 13; 101(2): 517–522. Published online 2003 December 29. doi: 10.1073/pnas.0305665101.PMCID: PMC327179 Monitoring protein stability and aggregation in vivo by real-time fluorescent labeling Zoya Ignatova and Lila M. Gierasch Proc Natl Acad Sci U S A. 2004 January 13; 101(2): 523–528. Published online 2003 December 30. doi: 10.1073/pnas.0304533101.PMCID: PMC327180 The catalytic cycle of cytochrome c oxidase is not the sum of its two halves Dmitry Bloch, Ilya Belevich, Audrius Jasaitis, Camilla Ribacka, Anne Puustinen, Michael I. Verkhovsky, and Mårten Wikström Proc Natl Acad Sci U S A. 2004 January 13; 101(2): 529–533. Published online 2003 December 29. doi: 10.1073/pnas.0306036101.PMCID: PMC327181 Single-molecule studies highlight conformational heterogeneity in the early folding steps of a large ribozyme Zheng Xie, Narayanan Srividya, Tobin R. Sosnick, Tao Pan, and Norbert F. Scherer Proc Natl Acad Sci U S A. 2004 January 13; 101(2): 534–539. Published online 2004 January 2. doi: 10.1073/pnas.2636333100.PMCID: PMC327182 Cell Biology Transcriptional signature of histone deacetylase inhibition in multiple myeloma: Biological and clinical implications Constantine S. Mitsiades, Nicholas S. Mitsiades, Ciaran J. McMullan, Vassiliki Poulaki, Reshma Shringarpure, Teru Hideshima, Masaharu Akiyama, Dharminder Chauhan, Nikhil Munshi, Xuesong Gu, Charles Bailey, Marie Joseph, Towia A. Libermann, Victoria M. Richon, Paul A. Marks, and Kenneth C. Anderson Proc Natl Acad Sci U S A. 2004 January 13; 101(2): 540–545. Published online 2003 December 26. doi: 10.1073/pnas.2536759100.PMCID: PMC327183 Regulation of synaptojanin 1 by cyclin-dependent kinase 5 at synapses Sang Yoon Lee, Markus R. Wenk, Yong Kim, Angus C. Nairn, and Pietro De Camilli Proc Natl Acad Sci U S A. 2004 January 13; 101(2): 546–551. Published online 2004 January 2. doi: 10.1073/pnas.0307813100.PMCID: PMC327184 Conditional targeting of E-cadherin in skin: Insights into hyperproliferative and degenerative responses Christopher L. Tinkle, Terry Lechler, H. Amalia Pasolli, and Elaine Fuchs Proc Natl Acad Sci U S A. 2004 January 13; 101(2): 552–557. Published online 2004 January 2. doi: 10.1073/pnas.0307437100.PMCID: PMC327185 Ecology From the Cover: Hatching failure increases with severity of population bottlenecks in birds James V. Briskie and Myles Mackintosh Proc Natl Acad Sci U S A. 2004 January 13; 101(2): 558–561. Published online 2003 December 29. doi: 10.1073/pnas.0305103101.PMCID: PMC327186 Response of C3 and C4 plants to middle-Holocene climatic variation near the prairie–forest ecotone of Minnesota David M. Nelson, Feng Sheng Hu, Jian Tian, Ivanka Stefanova, and Thomas A. Brown Proc Natl Acad Sci U S A. 2004 January 13; 101(2): 562–567. Published online 2003 December 30. doi: 10.1073/pnas.0307450100.PMCID: PMC327187 Evolution Phylogenetic evidence for the early evolution of microcystin synthesis Anne Rantala, David P. Fewer, Michael Hisbergues, Leo Rouhiainen, Jaana Vaitomaa, Thomas Börner, and Kaarina Sivonen Proc Natl Acad Sci U S A. 2004 January 13; 101(2): 568–573. Published online 2003 December 30. doi: 10.1073/pnas.0304489101.PMCID: PMC327188 Genetics Loss of CDX1 expression in colorectal carcinoma: Promoter methylation, mutation, and loss of heterozygosity analyses of 37 cell lines N. A. C. S. Wong, M. P. Britton, G. S. Choi, T. K. Stanton, D. C. Bicknell, J. L. Wilding, and W. F. Bodmer Proc Natl Acad Sci U S A. 2004 January 13; 101(2): 574–579. Published online 2004 January 2. doi: 10.1073/pnas.0307190101.PMCID: PMC327189 Design of genetic networks with specified functions by evolution in silico Paul François and Vincent Hakim Proc Natl Acad Sci U S A. 2004 January 13; 101(2): 580–585. Published online 2004 January 2. doi: 10.1073/pnas.0304532101.PMCID: PMC327190 Immunology IL-13 receptor α 2 down-modulates granulomatous inflammation and prolongs host survival in schistosomiasis Margaret M. Mentink-Kane, Allen W. Cheever, Robert W. Thompson, Danielle M. Hari, Narcis B. Kabatereine, Birgitte J. Vennervald, John H. Ouma, Joseph K. Mwatha, Frances M. Jones, Debra D. Donaldson, Michael J. Grusby, David W. Dunne, and Thomas A. Wynn Proc Natl Acad Sci U S A. 2004 January 13; 101(2): 586–590. Published online 2003 December 29. doi: 10.1073/pnas.0305064101.PMCID: PMC327191 Medical Sciences From the Cover: Role of prostaglandin E2-dependent angiogenic switch in cyclooxygenase 2-induced breast cancer progression Sung-Hee Chang, Catherine H. Liu, Rebecca Conway, David K. Han, Kasem Nithipatikom, Ovidiu C. Trifan, Timothy F. Lane, and Timothy Hla Proc Natl Acad Sci U S A. 2004 January 13; 101(2): 591–596. Published online 2003 December 19. doi: 10.1073/pnas.2535911100.PMCID: PMC327192 Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder Benjamin S. Braun, David A. Tuveson, Namie Kong, Doan T. Le, Scott C. Kogan, Jacob Rozmus, Michelle M. Le Beau, Tyler E. Jacks, and Kevin M. Shannon Proc Natl Acad Sci U S A. 2004 January 13; 101(2): 597–602. Published online 2003 December 29. doi: 10.1073/pnas.0307203101.PMCID: PMC327193 Electrocardiographic and other cardiac anomalies in β-glucuronidase-null mice corrected by nonablative neonatal marrow transplantation A. J. T. Schuldt, T. J. Hampton, V. Chu, C. A. Vogler, N. Galvin, M. D. Lessard, and J. E. Barker Proc Natl Acad Sci U S A. 2004 January 13; 101(2): 603–608. Published online 2004 January 2. doi: 10.1073/pnas.0305284101.PMCID: PMC327194 Defective lysosomal targeting of activated fibroblast growth factor receptor 3 in achondroplasia Jay Y. Cho, Changsheng Guo, Monica Torello, Gregory P. Lunstrum, Tomoko Iwata, Chuxia Deng, and William A. Horton Proc Natl Acad Sci U S A. 2004 January 13; 101(2): 609–614. Published online 2003 December 29. doi: 10.1073/pnas.2237184100.PMCID: PMC327195 In silico dissection of cell-type-associated patterns of gene expression in prostate cancer Robert O. Stuart, William Wachsman, Charles C. Berry, Jessica Wang-Rodriguez, Linda Wasserman, Igor Klacansky, Dan Masys, Karen Arden, Steven Goodison, Michael McClelland, Yipeng Wang, Anne Sawyers, Iveta Kalcheva, David Tarin, and Dan Mercola Proc Natl Acad Sci U S A. 2004 January 13; 101(2): 615–620. doi: 10.1073/pnas.2536479100.PMCID: PMC327196 Binding of mouse VL30 retrotransposon RNA to PSF protein induces genes repressed by PSF: Effects on steroidogenesis and oncogenesis Xu Song, Aiwei Sui, and Alan Garen Proc Natl Acad Sci U S A. 2004 January 13; 101(2): 621–626. Published online 2004 January 2. doi: 10.1073/pnas.0307794100.PMCID: PMC327197 Microbiology The chitinolytic cascade in Vibrios is regulated by chitin oligosaccharides and a two-component chitin catabolic sensor/kinase Xibing Li and Saul Roseman Proc Natl Acad Sci U S A. 2004 January 13; 101(2): 627–631. Published online 2003 December 29. doi: 10.1073/pnas.0307645100.PMCID: PMC327198 Nonrandom HIV-1 infection and double infection via direct and cell-mediated pathways Que Dang, Jianbo Chen, Derya Unutmaz, John M. Coffin, Vinay K. Pathak, Douglas Powell, Vineet N. KewalRamani, Frank Maldarelli, and Wei-Shau Hu Proc Natl Acad Sci U S A. 2004 January 13; 101(2): 632–637. Published online 2004 January 5. doi: 10.1073/pnas.0307636100.PMCID: PMC327199 Residual integrated viral DNA after hepadnavirus clearance by nucleoside analog therapy Jesse Summers and William S. Mason Proc Natl Acad Sci U S A. 2004 January 13; 101(2): 638–640. Published online 2003 December 29. doi: 10.1073/pnas.0307422100.PMCID: PMC327200 Transcriptome-based determination of multiple transcription regulator activities in Escherichia coli by using network component analysis Katy C. Kao, Young-Lyeol Yang, Riccardo Boscolo, Chiara Sabatti, Vwani Roychowdhury, and James C. Liao Proc Natl Acad Sci U S A. 2004 January 13; 101(2): 641–646. Published online 2003 December 23. doi: 10.1073/pnas.0305287101.PMCID: PMC327201 Neuroscience Identification of calcium- and nitric oxide-regulated genes by differential analysis of library expression (DAzLE) Huiwu Li, Xiujing Gu, Valina L. Dawson, and Ted M. Dawson Proc Natl Acad Sci U S A. 2004 January 13; 101(2): 647–652. Published online 2003 December 30. doi: 10.1073/pnas.0305145101.PMCID: PMC327202 NADH augments blood flow in physiologically activated retina and visual cortex Yasuo Ido, Katherine Chang, and Joseph R. Williamson Proc Natl Acad Sci U S A. 2004 January 13; 101(2): 653–658. Published online 2004 January 2. doi: 10.1073/pnas.0307458100.PMCID: PMC327203 Increased lactate/pyruvate ratio augments blood flow in physiologically activated human brain Mark A. Mintun, Andrei G. Vlassenko, Melissa M. Rundle, and Marcus E. Raichle Proc Natl Acad Sci U S A. 2004 January 13; 101(2): 659–664. Published online 2004 January 2. doi: 10.1073/pnas.0307457100.PMCID: PMC327204 JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease Stéphane Hunot, Miquel Vila, Peter Teismann, Roger J. Davis, Etienne C. Hirsch, Serge Przedborski, Pasko Rakic, and Richard A. Flavell Proc Natl Acad Sci U S A. 2004 January 13; 101(2): 665–670. Published online 2004 January 2. doi: 10.1073/pnas.0307453101.PMCID: PMC327205 Association of β-catenin with the α-subunit of neuronal large-conductance Ca2+-activated K+ channels F. Lesage, H. Hibino, and A. J. Hudspeth Proc Natl Acad Sci U S A. 2004 January 13; 101(2): 671–675. Published online 2003 December 30. doi: 10.1073/pnas.0307681100.PMCID: PMC327206 Protein phosphatase 2A inhibition induces cerebellar long-term depression and declustering of synaptic AMPA receptor T. Launey, S. Endo, R. Sakai, J. Harano, and M. Ito Proc Natl Acad Sci U S A. 2004 January 13; 101(2): 676–681. Published online 2003 December 29. doi: 10.1073/pnas.0302914101.PMCID: PMC327207 Functional expression in frog oocytes of human ρ1 receptors produced in Saccharomyces cerevisiae Alejandro Martínez-Martínez, Jorge Mauricio Reyes-Ruiz, Ataúlfo Martínez-Torres, and Ricardo Miledi Proc Natl Acad Sci U S A. 2004 January 13; 101(2): 682–686. Published online 2004 January 2. doi: 10.1073/pnas.0307564100.PMCID: PMC327208 Plant Biology RF2b, a rice bZIP transcription activator, interacts with RF2a and is involved in symptom development of rice tungro disease Shunhong Dai, Zhihong Zhang, Shouyi Chen, and Roger N. Beachy Proc Natl Acad Sci U S A. 2004 January 13; 101(2): 687–692. Published online 2004 January 2. doi: 10.1073/pnas.0307687100.PMCID: PMC327209 Correction Proc Natl Acad Sci U S A. 2004 January 13; 101(2): 693. Published online 2003 December 23. doi: 10.1073/pnas.2637170100.PMCID: PMC327210 Corrects: Kent E. Vrana, et al. Colloquium Paper: Regenerative Medicine: Nonhuman primate parthenogenetic stem cells. Proc Natl Acad Sci U S A. 2003 September 30; 100(Suppl 1): 11911–11916. |