| | This journal provides immediate access to some articles. Editorial PNAS goes weekly in the new year Nicholas R. Cozzarelli, Kenneth R. Fulton, and Diane M. Sullenberger PMCID: PMC314124 Commentaries Alcohol and inhibitory receptors: Unexpected specificity from a nonspecific drug R. A. Harris and S. J. Mihic PMCID: PMC314125 Methylation and epigenetic fidelity Arthur D. Riggs and Zhenggang Xiong PMCID: PMC314126 Shock-induced minerals in meteorite provide prospecting tools for mineral physics Harry W. Green, II PMCID: PMC314127 Perspective Hubble's diagram and cosmic expansion Robert P. Kirshner PMCID: PMC314128 Biography INAUGURAL ARTICLE by a Recently Elected Academy Member: Biography of Constance L. Cepko Christen Brownlee PMCID: PMC314129 Physical Sciences Applied Physical Sciences From the Cover:
Biomimetic ratcheting motion of a soft, slender, sessile gel L. Mahadevan, S. Daniel, and M. K. Chaudhury PMCID: PMC314131 Geophysics Could CO2-induced land-cover feedbacks alter near-shore upwelling regimes? Noah S. Diffenbaugh, Mark A. Snyder, and Lisa C. Sloan PMCID: PMC314132 Physics Magnetism in dense hexagonal iron Gerd Steinle-Neumann, Lars Stixrude, and Ronald E. Cohen PMCID: PMC314133 Biological Sciences Biochemistry Guanylyl cyclase is an ATP sensor coupling nitric oxide signaling to cell metabolism I. Ruiz-Stewart, S. R. Tiyyagura, J. E. Lin, S. Kazerounian, G. M. Pitari, S. Schulz, E. Martin, F. Murad, and S. A. Waldman PMCID: PMC314134 Dominant-negative C/EBP disrupts mitotic clonal expansion and differentiation of 3T3-L1 preadipocytes Jiang-Wen Zhang, Qi-Qun Tang, Charles Vinson, and M. Daniel Lane PMCID: PMC314135 A site-specific factor interacts directly with its cognate RNA editing site in chloroplast transcripts Tetsuya Miyamoto, Junichi Obokata, and Masahiro Sugiura PMCID: PMC314136 Selective abolition of pancreatic RNase binding to its inhibitor protein Kapil Kumar, Michael Brady, and Robert Shapiro PMCID: PMC314137 Crystal structure of a central stalk subunit C and reversible association/dissociation of vacuole-type ATPase Momi Iwata, Hiromi Imamura, Elizabeth Stambouli, Chiyo Ikeda, Masatada Tamakoshi, Koji Nagata, Hisayoshi Makyio, Ben Hankamer, Jim Barber, Masasuke Yoshida, Ken Yokoyama, and So Iwata PMCID: PMC314138 A deoxyribozyme that harnesses light to repair thymine dimers in DNA Daniel J.-F. Chinnapen and Dipankar Sen PMCID: PMC314139 Structure of HrcQB-C, a conserved component of the bacterial type III secretion systems Vasiliki E. Fadouloglou, Anastasia P. Tampakaki, Nicholas M. Glykos, Marina N. Bastaki, Jonathan M. Hadden, Simon E. Phillips, Nicholas J. Panopoulos, and Michael Kokkinidis PMCID: PMC314140 ATP-dependent interaction of the cytosolic domains of the inwardly rectifying K+ channel Kir6.2 revealed by fluorescence resonance energy transfer Takashi Tsuboi, Jonathan D. Lippiat, Frances M. Ashcroft, and Guy A. Rutter PMCID: PMC314141 Loss of poly(ADP-ribose) glycohydrolase causes progressive neurodegeneration in Drosophila melanogaster Shuji Hanai, Masayuki Kanai, Sayaka Ohashi, Keiji Okamoto, Mitsunori Yamada, Hitoshi Takahashi, and Masanao Miwa PMCID: PMC314142 Sequence determinants of amyloid fibril formation Manuela López de la Paz and Luis Serrano PMCID: PMC314143 U4 small nuclear RNA can function in both the major and minor spliceosomes Girish C. Shukla and Richard A. Padgett PMCID: PMC314144 Activation of Smad transcriptional activity by protein inhibitor of activated STAT3 (PIAS3) Jianyin Long, Guannan Wang, Isao Matsuura, Dongming He, and Fang Liu PMCID: PMC314145 Biophysics From the Cover:
Biomimetic ratcheting motion of a soft, slender, sessile gel L. Mahadevan, S. Daniel, and M. K. Chaudhury PMCID: PMC314131 Intracellular calmodulin availability accessed with two-photon cross-correlation Sally A. Kim, Katrin G. Heinze, M. Neal Waxham, and Petra Schwille PMCID: PMC314146 Local complexity of amino acid interactions in a protein core Rajul K. Jain and Rama Ranganathan PMCID: PMC314147 Energetics of ion conduction through the gramicidin channel Toby W. Allen, Olaf S. Andersen, and Benoît Roux PMCID: PMC314148 Structural, dynamic, and energetic aspects of long-range electron transfer in photosynthetic reaction centers Jan M. Kriegl and G. Ulrich Nienhaus PMCID: PMC314149 Detection of bacteria in suspension by using a superconducting quantum interference device H. L. Grossman, W. R. Myers, V. J. Vreeland, R. Bruehl, M. D. Alper, C. R. Bertozzi, and John Clarke PMCID: PMC314150 Cell Biology An approach to genomewide screens of expressed small interfering RNAs in mammalian cells Lianxing Zheng, Jun Liu, Sergei Batalov, Demin Zhou, Anthony Orth, Sheng Ding, and Peter G. Schultz PMCID: PMC314151 Epstein–Barr virus latent infection membrane protein 1 TRAF-binding site induces NIK/IKKα-dependent noncanonical NF-κB activation Micah Luftig, Teruhito Yasui, Vishal Soni, Myung-Soo Kang, Nils Jacobson, Ellen Cahir-McFarland, Brian Seed, and Elliott Kieff PMCID: PMC314152 Differentiation stage-specific activation of p38 mitogen-activated protein kinase isoforms in primary human erythroid cells Shahab Uddin, Jeong Ah-Kang, Jodie Ulaszek, Dolores Mahmud, and Amittha Wickrema PMCID: PMC314153 Mono- and multisite phosphorylation enhances Bcl2's antiapoptotic function and inhibition of cell cycle entry functions Xingming Deng, Fengqin Gao, Tammy Flagg, and W. Stratford May, Jr. PMCID: PMC314154 Developmental Biology A functional genomic screen for cardiogenic genes using RNA interference in developing Drosophila embryos Yong-Ou Kim, Sang-Joon Park, Robert S. Balaban, Marshall Nirenberg, and Yongsok Kim PMCID: PMC314155 Thyroid hormone controls the development of connections between the spinal cord and limbs during Xenopus laevis metamorphosis Nicholas Marsh-Armstrong, Liquan Cai, and Donald D. Brown PMCID: PMC314156 Ecology Genetic introgression as a potential to widen a species' niche: Insights from alpine Carex curvula P. Choler, B. Erschbamer, A. Tribsch, L. Gielly, and P. Taberlet PMCID: PMC314157 Variable ecological effects of hurricanes: The importance of seasonal timing for survival of lizards on Bahamian islands Thomas W. Schoener, David A. Spiller, and Jonathan B. Losos PMCID: PMC314158 Alleviating spatial conflict between people and biodiversity Gary W. Luck, Taylor H. Ricketts, Gretchen C. Daily, and Marc Imhoff PMCID: PMC314159 Evolution Random walks in the history of life James L. Cornette and Bruce S. Lieberman PMCID: PMC314160 Genetics Mutant human cells with constitutive activation of NF-κB Swati S. Sathe, Nywana Sizemore, Xiaoxia Li, Kalpa Vithalani, Mairead Commane, Shannon M. Swiatkowski, and George R. Stark PMCID: PMC314161 Pharmacogenetic rescue in time and space of the rutabaga memory impairment by using Gene-Switch Zhengmei Mao, Gregg Roman, Lin Zong, and Ronald L. Davis PMCID: PMC314162 From the Cover:
Hairpin-bisulfite PCR: Assessing epigenetic methylation patterns on complementary strands of individual DNA molecules Charles D. Laird, Nicole D. Pleasant, Aaron D. Clark, Jessica L. Sneeden, K. M. Anwarul Hassan, Nathan C. Manley, Jay C. Vary, Jr., Todd Morgan, R. Scott Hansen, and Reinhard Stöger PMCID: PMC314163 Immunology Thymic selection can compensate for mutations affecting T cell activation and generate a normal T cell repertoire in mutant mice Stephan Kissler, Linrong Lu, and Harvey Cantor PMCID: PMC314164 The C-type lectin SIGN-R1 mediates uptake of the capsular polysaccharide of Streptococcus pneumoniae in the marginal zone of mouse spleen Young-Sun Kang, Jae Y. Kim, Sandra A. Bruening, Maggi Pack, Anna Charalambous, Alla Pritsker, Thomas M. Moran, Jutta M. Loeffler, Ralph M. Steinman, and Chae Gyu Park PMCID: PMC314165 Shifting foci of hematopoiesis during reconstitution from single stem cells Yu-An Cao, Amy J. Wagers, Andreas Beilhack, Joan Dusich, Michael H. Bachmann, Robert S. Negrin, Irving L. Weissman, and Christopher H. Contag PMCID: PMC314166 Dissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effects Heike Schäcke, Arndt Schottelius, Wolf-Dietrich Döcke, Peter Strehlke, Stefan Jaroch, Norbert Schmees, Hartmut Rehwinkel, Hartwig Hennekes, and Khusru Asadullah PMCID: PMC314167 From the Cover:
IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts Sarah M. McWhirter, Katherine A. Fitzgerald, Jacqueline Rosains, Daniel C. Rowe, Douglas T. Golenbock, and Tom Maniatis PMCID: PMC314168 Demonstration of the Burkitt's lymphoma Epstein-Barr virus phenotype in dividing latently infected memory cells in vivo Donna Hochberg, Jaap M. Middeldorp, Michelle Catalina, John L. Sullivan, Katherine Luzuriaga, and David A. Thorley-Lawson PMCID: PMC314169 T cell chemotaxis to lysophosphatidylcholine through the G2A receptor Caius G. Radu, Li V. Yang, Mireille Riedinger, Matthew Au, and Owen N. Witte PMCID: PMC314170 Dynamic alterations in the conformation of the Ifng gene region during T helper cell differentiation Elvira R. Eivazova and Thomas M. Aune PMCID: PMC314171 Hybridoma-free generation of monoclonal antibodies Renata Pasqualini and Wadih Arap PMCID: PMC314172 The genomic arrangement of T cell receptor variable genes is a determinant of the developmental rearrangement pattern Na Xiong, Jeanne E. Baker, Chulho Kang, and David H. Raulet PMCID: PMC314173 Medical Sciences Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1 Frank Kuhnert, Corrine R. Davis, Hsiao-Ting Wang, Pauline Chu, Mark Lee, Jenny Yuan, Roel Nusse, and Calvin J. Kuo PMCID: PMC314174 From the Cover:
A human complement receptor 1 polymorphism that reduces Plasmodium falciparum rosetting confers protection against severe malaria Ian A. Cockburn, Margaret J. Mackinnon, Angela O'Donnell, Stephen J. Allen, Joann M. Moulds, Moses Baisor, Moses Bockarie, John C. Reeder, and J. Alexandra Rowe PMCID: PMC314175 Latent infection membrane protein transmembrane FWLY is critical for intermolecular interaction, raft localization, and signaling Teruhito Yasui, Micah Luftig, Vishal Soni, and Elliott Kieff PMCID: PMC314176 Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia Eric M. Reiman, Kewei Chen, Gene E. Alexander, Richard J. Caselli, Daniel Bandy, David Osborne, Ann M. Saunders, and John Hardy PMCID: PMC314177 A Plasmodium falciparum candidate vaccine based on a six-antigen polyprotein encoded by recombinant poxviruses Eric Prieur, Sarah C. Gilbert, Joerg Schneider, Anne C. Moore, Eric G. Sheu, Nilu Goonetilleke, Kathryn J. H. Robson, and Adrian V. S. Hill PMCID: PMC314178 Reversing established sepsis with antagonists of endogenous high-mobility group box 1 Huan Yang, Mahendar Ochani, Jianhua Li, Xiaoling Qiang, Mahira Tanovic, Helena E. Harris, Srinivas M. Susarla, Luis Ulloa, Hong Wang, Robert DiRaimo, Christopher J. Czura, Haichao Wang, Jesse Roth, H. Shaw Warren, Mitchell P. Fink, Matthew J. Fenton, Ulf Andersson, and Kevin J. Tracey PMCID: PMC314179 Microbiology The crystal structure of Pseudomonas avirulence protein AvrPphB: A papain-like fold with a distinct substrate-binding site Minfeng Zhu, Feng Shao, Roger W. Innes, Jack E. Dixon, and Zhaohui Xu PMCID: PMC314180 3D structure of the influenza virus polymerase complex: Localization of subunit domains Estela Area, Jaime Martín-Benito, Pablo Gastaminza, Eva Torreira, José M. Valpuesta, José L. Carrascosa, and Juan Ortín PMCID: PMC314181 A polyketide synthase catalyzes the last condensation step of mycolic acid biosynthesis in mycobacteria and related organisms Damien Portevin, Célia de Sousa-D'Auria, Christine Houssin, Christine Grimaldi, Mohamed Chami, Mamadou Daffé, and Christophe Guilhot PMCID: PMC314182 Neuroscience From the Cover: INAUGURAL ARTICLE by a Recently Elected Academy Member: Electroporation and RNA interference in the rodent retina in vivo and in vitroTakahiko Matsuda and Constance L. Cepko PMCID: PMC314130 Distinct forms of cholinergic modulation in parallel thalamic sensory pathways D. M. Mooney, L. Zhang, C. Basile, V. V. Senatorov, J. Ngsee, A. Omar, and B. Hu PMCID: PMC314183 Motor training compensates for cerebellar dysfunctions caused by oligodendrocyte ablation Ludovic Collin, Alessandro Usiello, Eric Erbs, Carole Mathis, and Emiliana Borrelli PMCID: PMC314184 Neurotoxic effects of polymorphonuclear granulocytes on hippocampal primary cultures Klaus Dinkel, Firdaus S. Dhabhar, and Robert M. Sapolsky PMCID: PMC314185 Learning rules and network repair in spike-timing-based computation networks J. J. Hopfield and Carlos D. Brody PMCID: PMC314186 Increased hippocampal neurogenesis in Alzheimer's disease Kunlin Jin, Alyson L. Peel, Xiao Ou Mao, Lin Xie, Barbara A. Cottrell, David C. Henshall, and David A. Greenberg PMCID: PMC314187 DNA-methyltransferase 1 mRNA is selectively overexpressed in telencephalic GABAergic interneurons of schizophrenia brains M. Veldic, H. J. Caruncho, W. S. Liu, J. Davis, R. Satta, D. R. Grayson, A. Guidotti, and E. Costa PMCID: PMC314188 Enhanced hippocampal noradrenaline and serotonin release in galanin-overexpressing mice after repeated forced swimming test Takashi Yoshitake, Fu-Hua Wang, Eugenia Kuteeva, Kristina Holmberg, Masatoshi Yamaguchi, Jacqueline N. Crawley, Robert Steiner, Tamas Bartfai, Sven Ove Ögren, Tomas Hökfelt, and Jan Kehr PMCID: PMC314189 Identification of many microRNAs that copurify with polyribosomes in mammalian neurons John Kim, Anna Krichevsky, Yonatan Grad, Gabriel D. Hayes, Kenneth S. Kosik, George M. Church, and Gary Ruvkun PMCID: PMC314190 An egalitarian network model for the emergence of simple and complex cells in visual cortex Louis Tao, Michael Shelley, David McLaughlin, and Robert Shapley PMCID: PMC314191 Role of serotonin in cocaine effects in mice with reduced dopamine transporter function Yolanda Mateo, Evgeny A. Budygin, Carrie E. John, and Sara R. Jones PMCID: PMC314192 Pharmacology Heptahelical domain of metabotropic glutamate receptor 5 behaves like rhodopsin-like receptors Cyril Goudet, Florence Gaven, Julie Kniazeff, Claire Vol, Jiangfeng Liu, Martin Cohen-Gonsaud, Francine Acher, Laurent Prézeau, and Jean Philippe Pin PMCID: PMC314193 Physiology Chronic exposure to nitric oxide alters the free iron pool in endothelial cells: Role of mitochondrial respiratory complexes and heat shock proteins Anup Ramachandran, Erin Ceaser, and Victor M. Darley-Usmar PMCID: PMC314194 Stimulatory and inhibitory protein kinase C consensus sequences regulate the cystic fibrosis transmembrane conductance regulator Valerie Chappe, Deborah A. Hinkson, L. Daniel Howell, Alexandra Evagelidis, Jie Liao, Xiu-Bao Chang, John R. Riordan, and John W. Hanrahan PMCID: PMC314195 Cell swelling, heat, and chemical agonists use distinct pathways for the activation of the cation channel TRPV4 J. Vriens, H. Watanabe, A. Janssens, G. Droogmans, T. Voets, and B. Nilius PMCID: PMC314196 Plant Biology The Arabidopsis LUT1 locus encodes a member of the cytochrome P450 family that is required for carotenoid ε-ring hydroxylation activity Li Tian, Valeria Musetti, Joonyul Kim, Maria Magallanes-Lundback, and Dean DellaPenna PMCID: PMC314197 Population Biology Anatomy of a chaotic attractor: Subtle model-predicted patterns revealed in population data Aaron A. King, R. F. Costantino, J. M. Cushing, Shandelle M. Henson, Robert A. Desharnais, and Brian Dennis PMCID: PMC314198 Corrections Proc Natl Acad Sci U S A. 2004 January 6; 101(1): 414. Published online 2003 December 17. doi: 10.1073/pnas.2636937100.PMCID: PMC314199 Corrects: Anamaria A. Camargo, et al. From the Cover:
The contribution of 700,000 ORF sequence tags to the definition of the human transcriptome. Proc Natl Acad Sci U S A. 2001 October 9; 98(21): 12103–12108. Proc Natl Acad Sci U S A. 2004 January 6; 101(1): 414. Published online 2003 December 17. doi: 10.1073/pnas.2536465100.PMCID: PMC314200 Corrects: Joseph Fargione, et al. Community assembly and invasion: An experimental test of neutral versus
niche processes. Proc Natl Acad Sci U S A. 2003 July 22; 100(15): 8916–8920. |
