| | This journal provides immediate access to some articles. Commentaries A role for extracellular matrix binding receptors in regulating hematopoietic growth factor signaling Richard B. Gaynor PMCID: PMC283489 Function-specific variations in the immunological synapses formed by cytotoxic T cells Darrell J. Irvine PMCID: PMC283490 Physical Sciences Applied Physical Sciences Computational mathematics and physics of fusion reactors Paul R. Garabedian PMCID: PMC283491 Chemistry Site- and sequence-selective ultrafast hydration of DNA Samir Kumar Pal, Liang Zhao, Tianbing Xia, and Ahmed H. Zewail PMCID: PMC283492 Base pair analogs in the gas phase Joseph R. Roscioli and David W. Pratt PMCID: PMC283493 Engineering From the Cover:
Microfabricated needles for transdermal delivery of macromolecules and nanoparticles: Fabrication methods and transport studies Devin V. McAllister, Ping M. Wang, Shawn P. Davis, Jung-Hwan Park, Paul J. Canatella, Mark G. Allen, and Mark R. Prausnitz PMCID: PMC283494 Biological Sciences Applied Biological Sciences Cancer risks attributable to low doses of ionizing radiation: Assessing what we really know David J. Brenner, Richard Doll, Dudley T. Goodhead, Eric J. Hall, Charles E. Land, John B. Little, Jay H. Lubin, Dale L. Preston, R. Julian Preston, Jerome S. Puskin, Elaine Ron, Rainer K. Sachs, Jonathan M. Samet, Richard B. Setlow, and Marco Zaider PMCID: PMC283495 Biochemistry Locking the DNA topoisomerase I protein clamp inhibits DNA rotation and induces cell lethality Michael H. Woo, Carmen Losasso, Hong Guo, Luca Pattarello, Piero Benedetti, and Mary-Ann Bjornsti PMCID: PMC283496 Shade is the Drosophila P450 enzyme that mediates the hydroxylation of ecdysone to the steroid insect molting hormone 20-hydroxyecdysone Anna Petryk, James T. Warren, Guillermo Marqués, Michael P. Jarcho, Lawrence I. Gilbert, Jonathan Kahler, Jean-Philippe Parvy, Yutai Li, Chantal Dauphin-Villemant, and Michael B. O'Connor PMCID: PMC283497 Disulfide bond formation involves a quinhydrone-type charge–transfer complex James Regeimbal, Stefan Gleiter, Bernard L. Trumpower, Chang-An Yu, Mithun Diwakar, David P. Ballou, and James C. A. Bardwell PMCID: PMC283498 Redesigning the monovalent cation specificity of an enzyme Swati Prasad, Kelly J. Wright, Dolly Banerjee Roy, Leslie A. Bush, Angelene M. Cantwell, and Enrico Di Cera PMCID: PMC283499 Regulation of survivin function by Hsp90 Paola Fortugno, Elena Beltrami, Janet Plescia, Jason Fontana, Deepti Pradhan, Pier Carlo Marchisio, William C. Sessa, and Dario C. Altieri PMCID: PMC283500 Conversion of the allosteric transition of GroEL from concerted to sequential by the single mutation Asp-155 → Ala Oded Danziger, Dalia Rivenzon-Segal, Sharon G. Wolf, and Amnon Horovitz PMCID: PMC283501 Mapping dominant-negative mutations of anthrax protective antigen by scanning mutagenesis Michael Mourez, Ming Yan, D. Borden Lacy, Lisa Dillon, Lori Bentsen, Amy Marpoe, Clémence Maurin, Eileen Hotze, Darran Wigelsworth, Ruth-Anne Pimental, Jimmy D. Ballard, R. John Collier, and Rodney K. Tweten PMCID: PMC283502 Cellulosome assembly revealed by the crystal structure of the cohesin–dockerin complex Ana L. Carvalho, Fernando M. V. Dias, José A. M. Prates, Tibor Nagy, Harry J. Gilbert, Gideon J. Davies, Luís M. A. Ferreira, Maria J. Romão, and Carlos M. G. A. Fontes PMCID: PMC283503 Trimeric structure for an essential protein in L1 retrotransposition Sandra L. Martin, Dan Branciforte, David Keller, and David L. Bain PMCID: PMC283504 X-ray structure of glutathione S-transferase from the malarial parasite Plasmodium falciparum Karin Fritz-Wolf, Andreas Becker, Stefan Rahlfs, Petra Harwaldt, R. Heiner Schirmer, Wolfgang Kabsch, and Katja Becker PMCID: PMC283505 Replication protein A-mediated recruitment and activation of Rad17 complexes Lee Zou, Dou Liu, and Stephen J. Elledge PMCID: PMC283506 Transcription-dependent degradation controls the stability of the SREBP family of transcription factors Anders Sundqvist and Johan Ericsson PMCID: PMC283507 J protein cochaperone of the mitochondrial inner membrane required for protein import into the mitochondrial matrix Patrick D. D'Silva, Brenda Schilke, William Walter, Amy Andrew, and Elizabeth A. Craig PMCID: PMC283508 Target-specific utilization of transcriptional regulatory surfaces by the glucocorticoid receptor Inez Rogatsky, Jen-Chywan Wang, Mika K. Derynck, Daisuke F. Nonaka, Daniel B. Khodabakhsh, Christopher M. Haqq, Beatrice D. Darimont, Michael J. Garabedian, and Keith R. Yamamoto PMCID: PMC283509 Biomolecular mimicry in the actin cytoskeleton: Mechanisms underlying the cytotoxicity of kabiramide C and related macrolides Junichi Tanaka, Yuling Yan, Jeongeun Choi, Jihong Bai, Vadim A. Klenchin, Ivan Rayment, and Gerard Marriott PMCID: PMC283510 ATP requirement for Prp5p function is determined by Cus2p and the structure of U2 small nuclear RNA Rhonda Perriman, Imre Barta, Gia K. Voeltz, John Abelson, and Manuel Ares, Jr. PMCID: PMC283511 Coevolution of an aminoacyl-tRNA synthetase with its tRNA substrates Juan C. Salazar, Ivan Ahel, Omar Orellana, Debra Tumbula-Hansen, Robert Krieger, Lacy Daniels, and Dieter Söll PMCID: PMC283512 Spermidine but not spermine is essential for hypusine biosynthesis and growth in Saccharomyces cerevisiae: Spermine is converted to spermidine in vivo by the FMS1-amine oxidase Manas K. Chattopadhyay, Celia White Tabor, and Herbert Tabor PMCID: PMC283513 The dual nature of human extracellular superoxide dismutase: One sequence and two structures Steen V. Petersen, Tim D. Oury, Zuzana Valnickova, Ida B. Thøgersen, Peter Højrup, James D. Crapo, and Jan J. Enghild PMCID: PMC283514 The isoniazid-NAD adduct is a slow, tight-binding inhibitor of InhA, the Mycobacterium tuberculosis enoyl reductase: Adduct affinity and drug resistance Richa Rawat, Adrian Whitty, and Peter J. Tonge PMCID: PMC283515 Association of the Mediator complex with enhancers of active genes Laurent Kuras, Tilman Borggrefe, and Roger D. Kornberg PMCID: PMC283516 Translationally controlled tumor protein acts as a guanine nucleotide dissociation inhibitor on the translation elongation factor eEF1A Christophe Cans, Brent J. Passer, Vyacheslav Shalak, Vanessa Nancy-Portebois, Virginie Crible, Nathalie Amzallag, David Allanic, Rowena Tufino, Manuela Argentini, Dino Moras, Giusy Fiucci, Bruno Goud, Marc Mirande, Robert Amson, and Adam Telerman PMCID: PMC283517 Biophysics Site- and sequence-selective ultrafast hydration of DNA Samir Kumar Pal, Liang Zhao, Tianbing Xia, and Ahmed H. Zewail PMCID: PMC283492 Folding a protein in a computer: An atomic description of the folding/unfolding of protein A Angel E. García and José N. Onuchic PMCID: PMC283518 RNA backbone is rotameric Laura J. W. Murray, W. Bryan Arendall, III, David C. Richardson, and Jane S. Richardson PMCID: PMC283519 From the Cover:
Influence of topology on bacterial social interaction Sungsu Park, Peter M. Wolanin, Emil A. Yuzbashyan, Hai Lin, Nicholas C. Darnton, Jeffry B. Stock, Pascal Silberzan, and Robert Austin PMCID: PMC283520 Exploring Flory's isolated-pair hypothesis: Statistical mechanics of helix–coil transitions in polyalanine and the C-peptide from RNase A Y. Zenmei Ohkubo and Charles L. Brooks, III PMCID: PMC283521 Atomistic understanding of kinetic pathways for single base-pair binding and unbinding in DNA Michael F. Hagan, Aaron R. Dinner, David Chandler, and Arup K. Chakraborty PMCID: PMC283522 Differential hydrophobicity drives self-assembly in Huntington's disease Martin G. Burke, Rüdiger Woscholski, and S. N. Yaliraki PMCID: PMC283523 Simulation of the folding equilibrium of α-helical peptides: A comparison of the generalized Born approximation with explicit solvent Hugh Nymeyer and Angel E. García PMCID: PMC283524 Channelrhodopsin-2, a directly light-gated cation-selective membrane channel Georg Nagel, Tanjef Szellas, Wolfram Huhn, Suneel Kateriya, Nona Adeishvili, Peter Berthold, Doris Ollig, Peter Hegemann, and Ernst Bamberg PMCID: PMC283525 Crystal structure of a hydrophobic 19-residue peptide helix containing three centrally located d amino acids Isabella L. Karle, Hosahudya N. Gopi, and Padmanabhan Balaram PMCID: PMC283526 On the relation between fluctuation and response in biological systems Katsuhiko Sato, Yoichiro Ito, Tetsuya Yomo, and Kunihiko Kaneko PMCID: PMC283550 Cell Biology Regulation of zinc homeostasis by inducible NO synthase-derived NO: Nuclear metallothionein translocation and intranuclear Zn2+ release Daniela U. Spahl, Denise Berendji-Grün, Christoph V. Suschek, Victoria Kolb-Bachofen, and Klaus-D. Kröncke PMCID: PMC283527 Myosin XVa localizes to the tips of inner ear sensory cell stereocilia and is essential for staircase formation of the hair bundle Inna A. Belyantseva, Erich T. Boger, and Thomas B. Friedman PMCID: PMC283528 Membrane cholesterol, lateral mobility, and the phosphatidylinositol 4,5-bisphosphate-dependent organization of cell actin Jeanne Kwik, Sarah Boyle, David Fooksman, Leonid Margolis, Michael P. Sheetz, and Michael Edidin PMCID: PMC283529 IIp45, an insulin-like growth factor binding protein 2 (IGFBP-2) binding protein, antagonizes IGFBP-2 stimulation of glioma cell invasion Sonya W. Song, Gregory N. Fuller, Asadullah Khan, Shouming Kong, Weiping Shen, Ellen Taylor, Latha Ramdas, Frederick F. Lang, and Wei Zhang PMCID: PMC283530 TPPP/p25 promotes tubulin assemblies and blocks mitotic spindle formation L. Tirián, E. Hlavanda, J. Oláh, I. Horváth, F. Orosz, B. Szabó, J. Kovács, J. Szabad, and J. Ovádi PMCID: PMC283531 The glycine neurotransmitter transporter GLYT1 is an organic osmolyte transporter regulating cell volume in cleavage-stage embryos Candace L. Steeves, Mary-Anne Hammer, Glenn B. Walker, Duncan Rae, Nicolas A. Stewart, and Jay M. Baltz PMCID: PMC283532 Atypical methylation of the interleukin-8 gene correlates strongly with the metastatic potential of breast carcinoma cells Joseph E. De Larco, Beverly R. K. Wuertz, Douglas Yee, Brenda L. Rickert, and Leo T. Furcht PMCID: PMC283533 Global analysis of ligand sensitivity of estrogen inducible and suppressible genes in MCF7/BUS breast cancer cells by DNA microarray Kathryn R. Coser, Jessica Chesnes, Jingyung Hur, Sandip Ray, Kurt J. Isselbacher, and Toshi Shioda PMCID: PMC283534 From the Cover:
The laminin receptor modulates granulocyte–macrophage colony-stimulating factor receptor complex formation and modulates its signaling Jian Chen, Juan M. Cárcamo, Oriana Bórquez-Ojeda, Hediye Erdjument-Bromage, Paul Tempst, and David W. Golde PMCID: PMC283535 Nuclear translocation of 3′-phosphoinositide-dependent protein kinase 1 (PDK-1): A potential regulatory mechanism for PDK-1 function Mei A. Lim, Chintan K. Kikani, Michael J. Wick, and Lily Q. Dong PMCID: PMC283536 Rab27b is associated with fusiform vesicles and may be involved in targeting uroplakins to urothelial apical membranes Yanru Chen, Xuemei Guo, Fang-Ming Deng, Feng-Xia Liang, Wenyu Sun, Mindong Ren, Tetsuro Izumi, David D. Sabatini, Tung-Tien Sun, and Gert Kreibich PMCID: PMC283537 Modulation of RNA editing by functional nucleolar sequestration of ADAR2 Christopher L. Sansam, K. Sam Wells, and Ronald B. Emeson PMCID: PMC283538 Developmental Biology Site-1 protease is required for cartilage development in zebrafish Kornelia Schlombs, Thomas Wagner, and Jochen Scheel PMCID: PMC283539 Endothelial lineage-mediated loss of the GATA cofactor Friend of GATA 1 impairs cardiac development Samuel G. Katz, Aimee Williams, Jifu Yang, Yuko Fujiwara, Alice P. Tsang, Jonathan A. Epstein, and Stuart H. Orkin PMCID: PMC283540 A newborn lethal defect due to inactivation of retinaldehyde dehydrogenase type 3 is prevented by maternal retinoic acid treatment Valérie Dupé, Nicolas Matt, Jean-Marie Garnier, Pierre Chambon, Manuel Mark, and Norbert B. Ghyselinck PMCID: PMC283541 Ovarian cystocytes can repopulate the embryonic germ line and produce functional gametes Yuzo Niki and Anthony P. Mahowald PMCID: PMC283542 Transgenic planarian lines obtained by electroporation using transposon-derived vectors and an eye-specific GFP marker C. González-Estévez, T. Momose, W. J. Gehring, and E. Saló PMCID: PMC283543 Ecology Forest fragmentation severs mutualism between seed dispersers and an endemic African tree Norbert J. Cordeiro and Henry F. Howe PMCID: PMC283544 Resting and daily energy expenditures of free-living field voles are positively correlated but reflect extrinsic rather than intrinsic effects J. R. Speakman, T. Ergon, R. Cavanagh, K. Reid, D. M. Scantlebury, and X. Lambin PMCID: PMC283545 Modeling current and future potential wintering distributions of eastern North American monarch butterflies Karen Oberhauser and A. Townsend Peterson PMCID: PMC283546 Rates of species loss from Amazonian forest fragments Gonçalo Ferraz, Gareth J. Russell, Philip C. Stouffer, Richard O. Bierregaard, Jr., Stuart L. Pimm, and Thomas E. Lovejoy PMCID: PMC283547 Evolution Divergent selection during speciation of Lake Malawi cichlid fishes inferred from parallel radiations in nuptial coloration Charlotte J. Allender, Ole Seehausen, Mairi E. Knight, George F. Turner, and Norman Maclean PMCID: PMC283548 Cell size as a link between noncoding DNA and metabolic rate scaling J. Kozłowski, M. Konarzewski, and A. T. Gawelczyk PMCID: PMC283549 On the relation between fluctuation and response in biological systems Katsuhiko Sato, Yoichiro Ito, Tetsuya Yomo, and Kunihiko Kaneko PMCID: PMC283550 Genetics HeT-A elements in Drosophila virilis: Retrotransposon telomeres are conserved across the Drosophila genus Elena Casacuberta and Mary-Lou Pardue PMCID: PMC283551 The ISWI ATPase Snf2h is required for early mouse development Tomas Stopka and Arthur I. Skoultchi PMCID: PMC283552 Development of an enhanced GFP-based dual-color reporter to facilitate genetic screens for the recovery of mutations in mice Aubrey C. Frank, Kimberly A. Meyers, Ian C. Welsh, and Timothy P. O'Brien PMCID: PMC283553 Wnk1 kinase deficiency lowers blood pressure in mice: A gene-trap screen to identify potential targets for therapeutic intervention Brian P. Zambrowicz, Alejandro Abuin, Ramiro Ramirez-Solis, Lizabeth J. Richter, James Piggott, Hector BeltrandelRio, Eric C. Buxton, Joel Edwards, Rick A. Finch, Carl J. Friddle, Anupma Gupta, Gwenn Hansen, Yi Hu, Wenhu Huang, Crystal Jaing, Billie Wayne Key, Jr., Peter Kipp, Buckley Kohlhauff, Zhi-Qing Ma, Diane Markesich, Robert Payne, David G. Potter, Ny Qian, Joseph Shaw, Jeff Schrick, Zheng-Zheng Shi, Mary Jean Sparks, Isaac Van Sligtenhorst, Peter Vogel, Wade Walke, Nianhua Xu, Qichao Zhu, Christophe Person, and Arthur T. Sands PMCID: PMC283554 Haplotype-based identification of a microsomal transfer protein marker associated with the human lifespan Bard J. Geesaman, Erica Benson, Stephanie J. Brewster, Louis M. Kunkel, Hélène Blanché, Gilles Thomas, Thomas T. Perls, Mark J. Daly, and Annibale A. Puca PMCID: PMC283555 The construction of an EST database for Bombyx mori and its application Kazuei Mita, Mitsuoki Morimyo, Kazuhiro Okano, Yoshiko Koike, Junko Nohata, Hideki Kawasaki, Keiko Kadono-Okuda, Kimiko Yamamoto, Masataka G. Suzuki, Toru Shimada, Marian R. Goldsmith, and Susumu Maeda PMCID: PMC283556 Exploring the functional complexity of cellular proteins by protein knockout Jianxuan Zhang, Ning Zheng, and Pengbo Zhou PMCID: PMC283557 SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer Biao He, Liang You, Kazutsugu Uematsu, Keling Zang, Zhidong Xu, Amie Y. Lee, Joseph F. Costello, Frank McCormick, and David M. Jablons PMCID: PMC283558 Immunology The role of reactive oxygen species on Plasmodium melanotic encapsulation in Anopheles gambiae Sanjeev Kumar, George K. Christophides, Rafael Cantera, Bradley Charles, Yeon Soo Han, Stephan Meister, George Dimopoulos, Fotis C. Kafatos, and Carolina Barillas-Mury PMCID: PMC283559 From the Cover:
Lytic versus stimulatory synapse in cytotoxic T lymphocyte/target cell interaction: Manifestation of a dual activation threshold Mustapha Faroudi, Clemens Utzny, Mariolina Salio, Vincenzo Cerundolo, Martine Guiraud, Sabina Müller, and Salvatore Valitutti PMCID: PMC283560 The mature activating natural killer cell immunologic synapse is formed in distinct stages Jordan S. Orange, K. Eliza Harris, Milena M. Andzelm, Markus M. Valter, Raif S. Geha, and Jack L. Strominger PMCID: PMC283561 Glatiramer acetate-specific T cells in the brain express T helper 2/3 cytokines and brain-derived neurotrophic factor in situ Rina Aharoni, Basak Kayhan, Raya Eilam, Michael Sela, and Ruth Arnon PMCID: PMC283562 B7h is required for T cell activation, differentiation, and effector function Roza I. Nurieva, Xoi Moui Mai, Katherine Forbush, Michael J. Bevan, and Chen Dong PMCID: PMC283563 Distinct pathways involving the FK506-binding proteins 12 and 12.6 underlie IL-2-versus IL-15-mediated proliferation of T cells Sigrid Dubois, Weinian Shou, Laura S. Haneline, Sidney Fleischer, Thomas A. Waldmann, and Jürgen R. Müller PMCID: PMC283564 Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim Marc Pellegrini, Gabrielle Belz, Philippe Bouillet, and Andreas Strasser PMCID: PMC283565 IL-18 cDNA vaccination protects mice from spontaneous lupus-like autoimmune disease Paola Bossù, Detlef Neumann, Elda Del Giudice, Antonio Ciaramella, Isabelle Gloaguen, Giamila Fantuzzi, Charles A. Dinarello, Emma Di Carlo, Piero Musiani, Pier Luigi Meroni, Gianfranco Caselli, Paolo Ruggiero, and Diana Boraschi PMCID: PMC283566 Medical Sciences Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Aβ production in APP23 transgenic mice Thomas A. Bayer, Stephanie Schäfer, Andreas Simons, André Kemmling, Thomas Kamer, Ralf Tepests, Anne Eckert, Katrin Schüssel, Oliver Eikenberg, Christine Sturchler-Pierrat, Dorothee Abramowski, Matthias Staufenbiel, and Gerd Multhaup PMCID: PMC283567 In vivo reduction of amyloid-β by a mutant copper transporter Amie L. Phinney, Bettina Drisaldi, Stephen D. Schmidt, Stan Lugowski, Veronica Coronado, Yan Liang, Patrick Horne, Jing Yang, Joannis Sekoulidis, Janaky Coomaraswamy, M. Azhar Chishti, Diane W. Cox, Paul M. Mathews, Ralph A. Nixon, George A. Carlson, Peter St George-Hyslop, and David Westaway PMCID: PMC283568 In vitro assay for neutralizing antibody to hepatitis C virus: Evidence for broadly conserved neutralization epitopes Birke Bartosch, Jens Bukh, Jean-Christophe Meunier, Christelle Granier, Ronald E. Engle, William C. Blackwelder, Suzanne U. Emerson, François-Loïc Cosset, and Robert H. Purcell PMCID: PMC283569 Platelet and osteoclast β3 integrins are critical for bone metastasis Suzanne J. Bakewell, Patrick Nestor, Srinivasa Prasad, Michael H. Tomasson, Nikki Dowland, Mukund Mehrotra, Robert Scarborough, James Kanter, Keith Abe, David Phillips, and Katherine N. Weilbaecher PMCID: PMC283570 Human adipocytes secrete mineralocorticoid-releasing factors M. Ehrhart-Bornstein, V. Lamounier-Zepter, A. Schraven, J. Langenbach, H. S. Willenberg, A. Barthel, H. Hauner, S. M. McCann, W. A. Scherbaum, and S. R. Bornstein PMCID: PMC283571 Sustained peripheral expression of transgene adiponectin offsets the development of diet-induced obesity in rats Stanislav Shklyaev, George Aslanidi, Michael Tennant, Victor Prima, Eric Kohlbrenner, Vadim Kroutov, Martha Campbell-Thompson, James Crawford, Eugene W. Shek, Philip J. Scarpace, and Sergei Zolotukhin PMCID: PMC283572 Functional profiling of a human cytomegalovirus genome Walter Dunn, Cassie Chou, Hong Li, Rong Hai, David Patterson, Viktor Stolc, Hua Zhu, and Fenyong Liu PMCID: PMC283573 Proteomic profiling of the NCI-60 cancer cell lines using new high-density reverse-phase lysate microarrays Satoshi Nishizuka, Lu Charboneau, Lynn Young, Sylvia Major, William C. Reinhold, Mark Waltham, Hosein Kouros-Mehr, Kimberly J. Bussey, Jae K. Lee, Virginia Espina, Peter J. Munson, Emanuel Petricoin, III, Lance A. Liotta, and John N. Weinstein PMCID: PMC283574 A20, a regulator of NFκB, maps to an atherosclerosis locus and differs between parental sensitive C57BL/6J and resistant FVB/N strains Susanne Idel, Hayes M. Dansky, and Jan L. Breslow PMCID: PMC283575 Identification, characterization, and gene expression profiling of endotoxin-induced myocarditis Ma-Li Wong, Fiona O'Kirwan, Nadia Khan, Jonas Hannestad, Kwok H. Wu, David Elashoff, Gregory Lawson, Philip W. Gold, Samuel M. McCann, and Julio Licinio PMCID: PMC283576 Induction of frameshift and base pair substitution mutations by the major DNA adduct of the endogenous carcinogen malondialdehyde Laurie A. VanderVeen, Muhammed F. Hashim, Yu Shyr, and Lawrence J. Marnett PMCID: PMC283577 Functional identification of distinct sets of antitumor activities mediated by the FKBP gene family Sylvia Fong, Leslie Mounkes, Yong Liu, Michael Maibaum, Eric Alonzo, Pierre-Yves Desprez, Ann D. Thor, Mohammed Kashani-Sabet, and Robert J. Debs PMCID: PMC283578 Dual-color fluorescence imaging distinguishes tumor cells from induced host angiogenic vessels and stromal cells Meng Yang, Lingna Li, Ping Jiang, A. R. Moossa, Sheldon Penman, and Robert M. Hoffman PMCID: PMC283579 Intracellular formation of ”undisruptable” dimers of inducible nitric oxide synthase Pawel J. Kolodziejski, Mohammad B. Rashid, and N. Tony Eissa PMCID: PMC283580 Epstein-Barr virus provides a survival factor to Burkitt's lymphomas Gregory Kennedy, Jun Komano, and Bill Sugden PMCID: PMC283581 A pilot study of high-throughput, sequence-based mutational profiling of primary human acute myeloid leukemia cell genomes Timothy J. Ley, Patrick J. Minx, Matthew J. Walter, Rhonda E. Ries, Hui Sun, Michael McLellan, John F. DiPersio, Daniel C. Link, Michael H. Tomasson, Timothy A. Graubert, Howard McLeod, Hanna Khoury, Mark Watson, William Shannon, Kathryn Trinkaus, Sharon Heath, James W. Vardiman, Michael A. Caligiuri, Clara D. Bloomfield, Jeffrey D. Milbrandt, Elaine R. Mardis, and Richard K. Wilson PMCID: PMC283582 Delivery of antimicrobials into parasites B. U. Samuel, B. Hearn, D. Mack, P. Wender, J. Rothbard, M. J. Kirisits, E. Mui, S. Wernimont, C. W. Roberts, S. P. Muench, D. W. Rice, S. T. Prigge, A. B. Law, and R. McLeod PMCID: PMC283583 Haploinsufficiency of Anx7 tumor suppressor gene and consequent genomic instability promotes tumorigenesis in the Anx7(+/-) mouse Meera Srivastava, Cristina Montagna, Ximena Leighton, Mirta Glasman, Shanmugam Naga, Ofer Eidelman, Thomas Ried, and Harvey B. Pollard PMCID: PMC283584 Differential responses to psychotherapy versus pharmacotherapy in patients with chronic forms of major depression and childhood trauma Charles B. Nemeroff, Christine M. Heim, Michael E. Thase, Daniel N. Klein, A. John Rush, Alan F. Schatzberg, Philip T. Ninan, James P. McCullough, Jr., Paul M. Weiss, David L. Dunner, Barbara O. Rothbaum, Susan Kornstein, Gabor Keitner, and Martin B. Keller PMCID: PMC283585 Ciliary neurotrophic factor improves diabetic parameters and hepatic steatosis and increases basal metabolic rate in db/db mice M. W. Sleeman, K. Garcia, R. Liu, J. D. Murray, L. Malinova, M. Moncrieffe, G. D. Yancopoulos, and S. J. Wiegand PMCID: PMC283586 A dinucleotide motif in oligonucleotides shows potent immunomodulatory activity and overrides species-specific recognition observed with CpG motif Ekambar R. Kandimalla, Lakshmi Bhagat, Fu-Gang Zhu, Dong Yu, Yan-Ping Cong, Daqing Wang, Jimmy X. Tang, Jin-Yan Tang, Cathrine F. Knetter, Egil Lien, and Sudhir Agrawal PMCID: PMC283587 Microbiology Murine cytomegalovirus paralyzes macrophages by blocking IFNγ-induced promoter assembly Daniel L. Popkin, Mark A. Watson, Elizabeth Karaskov, Gavin P. Dunn, Rod Bremner, and Herbert W. Virgin , IV PMCID: PMC283588 Human targets of Pseudomonas aeruginosa pyocyanin Huimin Ran, Daniel J. Hassett, and Gee W. Lau PMCID: PMC283589 Differential expression of iron-, carbon-, and oxygen-responsive mycobacterial genes in the lungs of chronically infected mice and tuberculosis patients Juliano Timm, Frank A. Post, Linda-Gail Bekker, Gabriele B. Walther, Helen C. Wainwright, Riccardo Manganelli, Wai-Tsing Chan, Liana Tsenova, Benjamin Gold, Issar Smith, Gilla Kaplan, and John D. McKinney PMCID: PMC283590 Apoptosis induced by environmental stresses and amphotericin B in Candida albicans Andrew J. Phillips, Ian Sudbery, and Mark Ramsdale PMCID: PMC283591 Inhibition of interferon signaling by dengue virus Jorge L. Muñoz-Jordán, Gilma G. Sánchez-Burgos, Maudry Laurent-Rolle, and Adolfo García-Sastre PMCID: PMC283592 Comprehensive transposon mutant library of Pseudomonas aeruginosa Michael A. Jacobs, Ashley Alwood, Iyarit Thaipisuttikul, David Spencer, Eric Haugen, Stephen Ernst, Oliver Will, Rajinder Kaul, Christopher Raymond, Ruth Levy, Liu Chun-Rong, Donald Guenthner, Donald Bovee, Maynard V. Olson, and Colin Manoil PMCID: PMC283593 Vaccinia virus encodes a previously uncharacterized mitochondrial-associated inhibitor of apoptosis Shawn T. Wasilenko, Tara L. Stewart, Adrienne F. A. Meyers, and Michele Barry PMCID: PMC283594 Nonorthologous replacement of lysyl-tRNA synthetase prevents addition of lysine analogues to the genetic code Brian C. Jester, Jeffrey D. Levengood, Hervé Roy, Michael Ibba, and Kevin M. Devine PMCID: PMC283595 From the Cover:
The Vibrio cholerae O139 O-antigen polysaccharide is essential for Ca2+-dependent biofilm development in sea water Katharine Kierek and Paula I. Watnick PMCID: PMC283596 Pneumococcal carriage results in ganglioside-mediated olfactory tissue infection Frederik W. van Ginkel, Jerry R. McGhee, James M. Watt, Antonio Campos-Torres, Lindsay A. Parish, and David E. Briles PMCID: PMC283597 Neuroscience Time-restricted role for dendritic activation of the mTOR-p70S6K pathway in the induction of late-phase long-term potentiation in the CA1 Maurizio Cammalleri, Robert Lütjens, Fulvia Berton, Alvin R. King, Cindy Simpson, Walter Francesconi, and Pietro Paolo Sanna PMCID: PMC283598 The fragile X mental retardation protein is required for type-I metabotropic glutamate receptor-dependent translation of PSD-95 Peter K. Todd, Kenneth J. Mack, and James S. Malter PMCID: PMC283599 Addicting drugs utilize a synergistic molecular mechanism in common requiring adenosine and Gi-βγ dimers Lina Yao, Peidong Fan, Zhan Jiang, William S. Mailliard, Adrienne S. Gordon, and Ivan Diamond PMCID: PMC283600 Spatial memory performances of aged rats in the water maze predict levels of hippocampal neurogenesis Elodie Drapeau, Willy Mayo, Catherine Aurousseau, Michel Le Moal, Pier-Vincenzo Piazza, and Djoher Nora Abrous PMCID: PMC283601 Dissection of K+ currents in Caenorhabditis elegans muscle cells by genetics and RNA interference C. M. Santi, A. Yuan, G. Fawcett, Z.-W. Wang, A. Butler, M. L. Nonet, A. Wei, P. Rojas, and L. Salkoff PMCID: PMC283602 Adenosine gates synaptic plasticity at hippocampal mossy fiber synapses Kimberly A. Moore, Roger A. Nicoll, and Dietmar Schmitz PMCID: PMC283603 BDNF induces translocation of initiation factor 4E to mRNA granules: Evidence for a role of synaptic microfilaments and integrins Fiona M. Smart, Gerald M. Edelman, and Peter W. Vanderklish PMCID: PMC283604 Measurement of unidirectional Pi to ATP flux in human visual cortex at 7 T by using in vivo 31P magnetic resonance spectroscopy Hao Lei, Kamil Ugurbil, and Wei Chen PMCID: PMC283605 Circadian modulation of long-term sensitization in Aplysia Raymond I. Fernandez, Lisa C. Lyons, Jonathan Levenson, Omar Khabour, and Arnold Eskin PMCID: PMC283606 Neurotrophin 3 activation of TrkC induces Schwann cell migration through the c-Jun N-terminal kinase pathway Junji Yamauchi, Jonah R. Chan, and Eric M. Shooter PMCID: PMC283607 Modeling facilitation and inhibition of competing motor programs in basal ganglia subthalamic nucleus–pallidal circuits Leonid L. Rubchinsky, Nancy Kopell, and Karen A. Sigvardt PMCID: PMC283608 A comprehensive analysis of 22q11 gene expression in the developing and adult brain T. M. Maynard, G. T. Haskell, A. Z. Peters, L. Sikich, J. A. Lieberman, and A.-S. LaMantia PMCID: PMC283609 Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by δ subunit-containing GABAA receptors Brandon M. Stell, Stephen G. Brickley, C. Y. Tang, Mark Farrant, and Istvan Mody* PMCID: PMC283610 Pharmacology Allosteric determinants in guanine nucleotide-binding proteins Mark E. Hatley, Steve W. Lockless, Scott K. Gibson, Alfred G. Gilman, and Rama Ranganathan¶ PMCID: PMC283611 Estrogen-related receptor α1 up-regulates endothelial nitric oxide synthase expression Daigo Sumi and Louis J. Ignarro PMCID: PMC283612 Physiology Compensation by the muscle limits the metabolic consequences of lipodystrophy in PPARγ hypomorphic mice Hana Koutnikova, Terrie-Anne Cock, Mitsuhiro Watanabe, Sander M. Houten, Marie-France Champy, Andrée Dierich, and Johan Auwerx PMCID: PMC283613 Quantitative evolutionary design of glucose 6-phosphate dehydrogenase expression in human erythrocytes Armindo Salvador and Michael A. Savageau PMCID: PMC283614 Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases Brian S. Finlin, Shawn M. Crump, Jonathan Satin, and Douglas A. Andres PMCID: PMC283615 Cardioprotection specific for the G protein Gi2 in chronic adrenergic signaling through β2-adrenoceptors Katharina Foerster, Ferdi Groner, Jan Matthes, Walter J. Koch, Lutz Birnbaumer, and Stefan Herzig PMCID: PMC283616 Plant Biology Menthofuran regulates essential oil biosynthesis in peppermint by controlling a downstream monoterpene reductase Soheil S. Mahmoud and Rodney B. Croteau PMCID: PMC283617 The classical Ubisch bodies carry a sporophytically produced structural protein (RAFTIN) that is essential for pollen development Aiming Wang, Qun Xia, Wenshuang Xie, Raju Datla, and Gopalan Selvaraj PMCID: PMC283618 Characterization of the requirements for localization of phytochrome B to nuclear bodies Meng Chen, Rebecca Schwab, and Joanne Chory PMCID: PMC283619 Psychology Computational evidence for a rivalry hierarchy in vision Hugh R. Wilson PMCID: PMC283620 Functional deactivations: Change with age and dementia of the Alzheimer type Cindy Lustig, Abraham Z. Snyder, Mehul Bhakta, Katherine C. O'Brien, Mark McAvoy, Marcus E. Raichle, John C. Morris, and Randy L. Buckner PMCID: PMC283621 Corrections Proc Natl Acad Sci U S A. 2003 November 25; 100(24): 14510. Published online 2003 November 4. doi: 10.1073/pnas.2436153100.PMCID: PMC283622 Corrects: Scott Classen, et al. Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187. Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10629–10634. Proc Natl Acad Sci U S A. 2003 November 25; 100(24): 14511. Published online 2003 October 30. doi: 10.1073/pnas.2536363100.PMCID: PMC283623 Corrects: Camilla L. Nesbø, et al. Active self-splicing group I introns in 23S rRNA genes of hyperthermophilic bacteria, derived from introns in eukaryotic organelles. Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10806–10811. Eduard D. Akhunov, Alina R. Akhunova, Anna M. Linkiewicz, Jorge Dubcovsky, David Hummel, Gerard R. Lazo, Shiaoman Chao, Olin D. Anderson, Jacques David, Lili Qi, Benjamin Echalier, Bikram S. Gill, Miftahudin, J. Perry Gustafson, Mauricio La Rota, Mark E. Sorrells, Deshui Zhang, Henry T. Nguyen, Venugopal Kalavacharla, Khwaja Hossain, Shahryar F. Kianian, Junhua Peng, Nora L. V. Lapitan, Emily J. Wennerlind, Vivienne Nduati, James A. Anderson, Deepak Sidhu, Kulvinder S. Gill, Patrick E. McGuire, Calvin O. Qualset, and Jan Dvorak PMCID: PMC283624 Corrects: Eduard D. Akhunov, et al. Synteny perturbations between wheat homoeologous chromosomes caused by locus duplications and deletions correlate with recombination rates. Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 10836–10841. Proc Natl Acad Sci U S A. 2003 November 25; 100(24): 14511. Published online 2003 October 29. doi: 10.1073/pnas.2536673100.PMCID: PMC283625 Corrects: Michael Overholtzer, et al. The presence of p53 mutations in human osteosarcomas correlates with high levels of genomic instability. Proc Natl Acad Sci U S A. 2003 September 30; 100(20): 11547–11552. Proc Natl Acad Sci U S A. 2003 November 25; 100(24): 14511. Published online 2003 November 13. doi: 10.1073/pnas.2536867100.PMCID: PMC283626 Corrects: Dion D. D. Hepburn, et al. Bioinorganic Chemistry Special Feature: Nutritional supplement chromium picolinate causes sterility and lethal mutations in Drosophila melanogaster. Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3766–3771. |
