| | This journal provides immediate access to some articles. Editorial Biographies of newly elected Academy members Nicholas R. Cozzarelli, Kenneth R. Fulton, Diane M. Sullenberger, and Bridget C. Coughlin PMCID: PMC263723 Commentaries Histone modifications: Now summoning sumoylation Dafna Nathan, David E. Sterner, and Shelley L. Berger PMCID: PMC263724 Cytochrome P450 flexibility Thomas L. Poulos PMCID: PMC263725 Similar neural mechanisms for emotion-induced memory impairment and enhancement Larry Cahill PMCID: PMC263726 Biography INAUGURAL ARTICLE by a Recently Elected Academy Member: Biography of John Bongaarts Christen Brownlee PMCID: PMC263727 Physical Sciences Applied Mathematics Saccharomyces cerevisiae phenotypes can be predicted by using constraint-based analysis of a genome-scale reconstructed metabolic network Iman Famili, Jochen Förster, Jens Nielsen, and Bernhard O. Palsson PMCID: PMC263729 Chemistry De novo designed cyclic-peptide heme complexes Michael M. Rosenblatt, Jiangyun Wang, and Kenneth S. Suslick PMCID: PMC263730 Revealing competitive Förster-type resonance energy-transfer pathways in single bichromophoric molecules Johan Hofkens, Mircea Cotlet, Tom Vosch, Philip Tinnefeld, Kenneth D. Weston, Christophe Ego, Andrew Grimsdale, Klaus Müllen, David Beljonne, Jean Luc Brédas, Sven Jordens, Gerd Schweitzer, Markus Sauer, and Frans De Schryver PMCID: PMC263731 Engineering Regulation of CD18 expression on neutrophils in response to fluid shear stress Shunichi Fukuda and Geert W. Schmid-Schönbein PMCID: PMC263732 Geophysics Contribution of climate-driven change in continental water storage to recent sea-level rise P. C. D. Milly, A. Cazenave, and C. Gennero PMCID: PMC263733 Physics Boundary of quantum evolution under decoherence Navin Khaneja, Burkhard Luy, and Steffen J. Glaser PMCID: PMC263734 Statistics Robust singular value decomposition analysis of microarray data Li Liu, Douglas M. Hawkins, Sujoy Ghosh, and S. Stanley Young PMCID: PMC263735 Biological Sciences Anthropology The anthropoid status of a primate from the late middle Eocene Pondaung Formation (Central Myanmar): Tarsal evidence Laurent Marivaux, Yaowalak Chaimanee, Stéphane Ducrocq, Bernard Marandat, Jean Sudre, Aung Naing Soe, Soe Thura Tun, Wanna Htoon, and Jean-Jacques Jaeger PMCID: PMC263736 Biochemistry Aqueous access pathways in subunit a of rotary ATP synthase extend to both sides of the membrane Christine M. Angevine, Kelly A. G. Herold, and Robert H. Fillingame PMCID: PMC263739 Creation of the first anomeric d/l-sugar kinase by means of directed evolution Dirk Hoffmeister, Jie Yang, Lesley Liu, and Jon S. Thorson PMCID: PMC263743 The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor Haitao Yang, Maojun Yang, Yi Ding, Yiwei Liu, Zhiyong Lou, Zhe Zhou, Lei Sun, Lijuan Mo, Sheng Ye, Hai Pang, George F. Gao, Kanchan Anand, Mark Bartlam, Rolf Hilgenfeld, and Zihe Rao PMCID: PMC263746 From the Cover:
An open conformation of mammalian cytochrome P450 2B4 at 1.6-Å resolution Emily E. Scott, You Ai He, Michael R. Wester, Mark A. White, Christopher C. Chin, James R. Halpert, Eric F. Johnson, and C. David Stout PMCID: PMC263748 Identification of functional similarities between proteins using directed evolution Daniel Christ and Greg Winter PMCID: PMC263750 The proteome of Saccharomyces cerevisiae mitochondria Albert Sickmann, Jörg Reinders, Yvonne Wagner, Cornelia Joppich, René Zahedi, Helmut E. Meyer, Birgit Schönfisch, Inge Perschil, Agnieszka Chacinska, Bernard Guiard, Peter Rehling, Nikolaus Pfanner, and Chris Meisinger PMCID: PMC263752 A specific endoribonuclease, RNase P, affects gene expression of polycistronic operon mRNAs Yong Li and Sidney Altman PMCID: PMC263755 Distinct peptide signals in the UmuD and UmuD′ subunits of UmuD/D′ mediate tethering and substrate processing by the ClpXP protease Saskia B. Neher, Robert T. Sauer, and Tania A. Baker PMCID: PMC263758 From the Cover:
Histone sumoylation is associated with transcriptional repression Yuzuru Shiio and Robert N. Eisenman PMCID: PMC263760 SecA-dependent quality control of intracellular protein localization Markus Eser and Michael Ehrmann PMCID: PMC263763 The two rotor components of yeast mitochondrial ATP synthase are mechanically coupled by subunit δ Stéphane Duvezin-Caubet, Matthieu Caron, Marie-France Giraud, Jean Velours, and Jean-Paul di Rago PMCID: PMC263764 DNA replication of mitotic chromatin in Xenopus egg extracts Tatyana A. Prokhorova, Karen Mowrer, Catherine H. Gilbert, and Johannes C. Walter PMCID: PMC263766 Escherichia coli nucleoside diphosphate kinase is a uracil-processing DNA repair nuclease Edith H. Postel and Bozena M. Abramczyk PMCID: PMC263769 Dynamics of the interaction between a fibronectin molecule and a living bacterium under mechanical force Yasser Bustanji, Carla Renata Arciola, Matteo Conti, Enrico Mandello, Lucio Montanaro, and Bruno Samorí PMCID: PMC263788 Biophysics A comparative study of motor-protein motions by using a simple elastic-network model Wenjun Zheng and Sebastian Doniach PMCID: PMC263771 Motility of Escherichia coli cells in clusters formed by chemotactic aggregation Nikhil Mittal, Elena O. Budrene, Michael P. Brenner, and Alexander van Oudenaarden PMCID: PMC263772 Identification of the protein kinase A regulatory RIα-catalytic subunit interface by amide H/2H exchange and protein docking Ganesh S. Anand, Dennis Law, Jeffrey G. Mandell, Aaron N. Snead, Igor Tsigelny, Susan S. Taylor, Lynn F. Ten Eyck, and Elizabeth A. Komives PMCID: PMC263775 Solution structure of a de novo protein from a designed combinatorial library Yinan Wei, Seho Kim, David Fela, Jean Baum, and Michael H. Hecht PMCID: PMC263778 Exploring the origins of binding specificity through the computational redesign of calmodulin Julia M. Shifman and Stephen L. Mayo PMCID: PMC263780 Trp-cage: Folding free energy landscape in explicit water Ruhong Zhou PMCID: PMC263783 Unifying features in protein-folding mechanisms Stefano Gianni, Nicholas R. Guydosh, Faaizah Khan, Teresa D. Caldas, Ugo Mayor, George W. N. White, Mari L. DeMarco, Valerie Daggett, and Alan R. Fersht PMCID: PMC263785 Dynamics of the interaction between a fibronectin molecule and a living bacterium under mechanical force Yasser Bustanji, Carla Renata Arciola, Matteo Conti, Enrico Mandello, Lucio Montanaro, and Bruno Samorí PMCID: PMC263788 Cell Biology Src kinase activation by direct interaction with the integrin β cytoplasmic domain Elena G. Arias-Salgado, Sergio Lizano, Sugata Sarkar, Joan S. Brugge, Mark H. Ginsberg, and Sanford J. Shattil PMCID: PMC263791 Rescue of mutants of the tumor suppressor p53 in cancer cells by a designed peptide Natalia Issaeva, Assaf Friedler, Przemyslaw Bozko, Klas G. Wiman, Alan R. Fersht, and Galina Selivanova PMCID: PMC263793 Visualizing the distribution and transport of mRNAs in living cells Diana P. Bratu, Byeong-Jik Cha, Musa M. Mhlanga, Fred Russell Kramer, and Sanjay Tyagi PMCID: PMC263795 A role for Arf1 in mitotic Golgi disassembly, chromosome segregation, and cytokinesis Nihal Altan-Bonnet, Robert D. Phair, Roman S. Polishchuk, Roberto Weigert, and Jennifer Lippincott-Schwartz PMCID: PMC263797 ADP-ribosylation factor 6 regulates insulin secretion through plasma membrane phosphatidylinositol 4,5-bisphosphate John T. R. Lawrence and Morris J. Birnbaum PMCID: PMC263800 NADPH oxidase and extracellular regulated kinases 1/2 are targets of prion protein signaling in neuronal and nonneuronal cells Benoît Schneider, Vincent Mutel, Mathéa Pietri, Myriam Ermonval, Sophie Mouillet-Richard, and Odile Kellermann PMCID: PMC263804 Endosomal compartmentalization in three dimensions: Implications for membrane fusion J. L. A. N. Murk, B. M. Humbel, U. Ziese, J. M. Griffith, G. Posthuma, J. W. Slot, A. J. Koster, A. J. Verkleij, H. J. Geuze, and M. J. Kleijmeer PMCID: PMC263806 Developmental Biology Posttranscriptional control of the competence factor βFTZ-F1 by juvenile hormone in the mosquito Aedes aegypti Jinsong Zhu, Li Chen, and Alexander S. Raikhel PMCID: PMC263810 From the Cover:
Paternal and maternal genomes confer opposite effects on proliferation, cell-cycle length, senescence, and tumor formation Lidia Hernandez, Serguei Kozlov, Graziella Piras, and Colin L. Stewart PMCID: PMC263813 Gene expression patterns in human embryonic stem cells and human pluripotent germ cell tumors Jamie M. Sperger, Xin Chen, Jonathan S. Draper, Jessica E. Antosiewicz, Chris H. Chon, Sunita B. Jones, James D. Brooks, Peter W. Andrews, Patrick O. Brown, and James A. Thomson PMCID: PMC263817 Developmental gene regulatory network architecture across 500 million years of echinoderm evolution Veronica F. Hinman, Albert T. Nguyen, R. Andrew Cameron, and Eric H. Davidson PMCID: PMC263818 Randomly inserted and targeted Hox/reporter fusions transcriptionally silenced in Polycomb mutants Wim de Graaff, Daihachiro Tomotsune, Tony Oosterveen, Yoshihiro Takihara, Haruhiko Koseki, and Jacqueline Deschamps PMCID: PMC263819 The Drosophila synaptotagmin-like protein bitesize is required for growth and has mRNA localization sequences within its open reading frame Julia Serano and Gerald M. Rubin PMCID: PMC263820 RNA interference-mediated knockdown of a GATA factor reveals a link to anautogeny in the mosquito Aedes aegypti Geoffrey M. Attardo, Stephen Higgs, Kimberley A. Klingler, Dana L. Vanlandingham, and Alexander S. Raikhel PMCID: PMC263821 Ecology Biomagnification of cyanobacterial neurotoxins and neurodegenerative disease among the Chamorro people of Guam Paul Alan Cox, Sandra Anne Banack, and Susan J. Murch PMCID: PMC263822 Invasion, competitive dominance, and resource use by exotic and native California grassland species Eric W. Seabloom, W. Stanley Harpole, O. J. Reichman, and David Tilman PMCID: PMC263823 Evolution Subadult experience influences adult mate choice in an arthropod: Exposed female wolf spiders prefer males of a familiar phenotype Eileen A. Hebets PMCID: PMC263824 Quantitative trait symmetry independent of Hsp90 buffering: Distinct modes of genetic canalization and developmental stability Claire C. Milton, Brandon Huynh, Philip Batterham, Suzanne L. Rutherford, and Ary A. Hoffmann PMCID: PMC263825 Functional constraints and frequency of deleterious mutations in noncoding DNA of rodents Peter D. Keightley and Daniel J. Gaffney PMCID: PMC263826 Adaptive evolution in the Arabidopsis MADS-box gene family inferred from its complete resolved phylogeny León Patricio Martínez-Castilla and Elena R. Alvarez-Buylla PMCID: PMC263827 Convergent neofunctionalization by positive Darwinian selection after ancient recurrent duplications of the xanthine dehydrogenase gene Francisco Rodríguez-Trelles, Rosa Tarrío, and Francisco J. Ayala PMCID: PMC263828 Genetics The generation and utilization of a cancer-oriented representation of the
human transcriptome by using expressed sequence tags Helena Brentani, Otávia L. Caballero, Anamaria A. Camargo, Aline M. da Silva, Wilson Araújo da Silva, Jr., Emmanuel Dias Neto, Marco Grivet, Arthur Gruber, Pedro Edson Moreira Guimaraes, Winston Hide, Christian Iseli, C. Victor Jongeneel, Janet Kelso, Maria Aparecida Nagai, Elida Paula Benquique Ojopi, Elisson C. Osorio, Eduardo M. R. Reis, Gregory J. Riggins, Andrew John George Simpson, Sandro de Souza, Brian J. Stevenson, Robert L. Strausberg, Eloiza H. Tajara, Sergio Verjovski-Almeida, The Human Cancer Genome Project Cancer Genome Anatomy Project
Annotation Consortium, and The Human Cancer Genome Project Sequencing Consortium PMCID: PMC263829 Loss-of-function mutations in the human GLI2 gene are associated with pituitary anomalies and holoprosencephaly-like features Erich Roessler, Yang-Zhu Du, Jose L. Mullor, Esther Casas, William P. Allen, Gabriele Gillessen-Kaesbach, Elizabeth R. Roeder, Jeffrey E. Ming, Ariel Ruiz i Altaba, and Maximilian Muenke PMCID: PMC263830 Evidence that the bypassing ribosome travels through the coding gap Jonathan Gallant, Paul Bonthuis, and Dale Lindsley PMCID: PMC263831 An endogenous Suppressor of Hairy-wing insulator separates regulatory domains in Drosophila Timothy J. Parnell, Michaela M. Viering, Astrid Skjesol, Cecilia Helou, Emily J. Kuhn, and Pamela K. Geyer PMCID: PMC263832 Multipoint linkage-disequilibrium mapping narrows location interval and identifies mutation heterogeneity Andrew P. Morris, John C. Whittaker, Chun-Fang Xu, Louise K. Hosking, and David J. Balding PMCID: PMC263833 Immunology Autoimmune cardiomyopathy and heart block develop spontaneously in HLA-DQ8 transgenic IAβ knockout NOD mice John F. Elliott, Junliang Liu, Zuan-Ning Yuan, Norma Bautista-Lopez, Sarah L. Wallbank, Kunimasa Suzuki, David Rayner, Patrick Nation, Murray A. Robertson, Gang Liu, and Katherine M. Kavanagh PMCID: PMC263834 Critical roles for IFN-β in lymphoid development, myelopoiesis, and tumor development: Links to tumor necrosis factor α Raj Deonarain, Amit Verma, Andrew C. G. Porter, Dirk R. Gewert, Leonidas C. Platanias, and Eleanor N. Fish PMCID: PMC263835 Normal B-1a cell development requires B cell-intrinsic NFATc1 activity Robert Berland and Henry H. Wortis PMCID: PMC263836 The T cell receptor β enhancer promotes access and pairing of Dβ and Jβ gene segments during V(D)J recombination Chun Jeih Ryu, Brian B. Haines, Dobrin D. Draganov, Yun Hee Kang, Charles E. Whitehurst, Tara Schmidt, Hyo Jeong Hong, and Jianzhu Chen PMCID: PMC263837 Premature telomeric loss in rheumatoid arthritis is genetically determined and involves both myeloid and lymphoid cell lineages Stefan O. Schönland, Consuelo Lopez, Thomas Widmann, Julia Zimmer, Ewa Bryl, Jörg J. Goronzy, and Cornelia M. Weyand PMCID: PMC263838 Endogenous neosynthesis vs. cross-presentation of viral antigens for cytotoxic T cell priming Stefan Freigang, Denise Egger, Kurt Bienz, Hans Hengartner, and Rolf M. Zinkernagel PMCID: PMC263839 Murine cytomegalovirus m157 mutation and variation leads to immune evasion of natural killer cells Valentina Voigt, Catherine A. Forbes, Joanne N. Tonkin, Mariapia A. Degli-Esposti, Hamish R. C. Smith, Wayne M. Yokoyama, and Anthony A. Scalzo PMCID: PMC263840 The inhibitory potential of Fc receptor homolog 4 on memory B cells Götz R. A. Ehrhardt, Randall S. Davis, Joyce T. Hsu, Chuen-Miin Leu, Annette Ehrhardt, and Max D. Cooper PMCID: PMC263841 Medical Sciences Regulation of CD18 expression on neutrophils in response to fluid shear stress Shunichi Fukuda and Geert W. Schmid-Schönbein PMCID: PMC263732 From the Cover:
Generation of hair cells by stepwise differentiation of embryonic stem cells Huawei Li, Graham Roblin, Hong Liu, and Stefan Heller PMCID: PMC263842 Pyrin binds the PSTPIP1/CD2BP1 protein, defining familial Mediterranean fever and PAPA syndrome as disorders in the same pathway Nitza G. Shoham, Michael Centola, Elizabeth Mansfield, Keith M. Hull, Geryl Wood, Carol A. Wise, and Daniel L. Kastner PMCID: PMC263843 An experimental platform for studying growth and invasiveness of tumor cells within teratomas derived from human embryonic stem cells Maty Tzukerman, Tzur Rosenberg, Yael Ravel, Irena Reiter, Raymond Coleman, and Karl Skorecki PMCID: PMC263844 A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors Joshua B. Rubin, Andrew L. Kung, Robyn S. Klein, Jennifer A. Chan, YanPing Sun, Karl Schmidt, Mark W. Kieran, Andrew D. Luster, and Rosalind A. Segal PMCID: PMC263845 A proatherogenic role for cGMP-dependent protein kinase in vascular smooth muscle cells Wiebke Wolfsgruber, Susanne Feil, Sabine Brummer, Oliver Kuppinger, Franz Hofmann, and Robert Feil PMCID: PMC263846 Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function Francine Côté, Etienne Thévenot, Cécile Fligny, Yves Fromes, Michèle Darmon, Marie-Anne Ripoche, Elisa Bayard, Naima Hanoun, Françoise Saurini, Philippe Lechat, Luisa Dandolo, Michel Hamon, Jacques Mallet, and Guilan Vodjdani PMCID: PMC263847 Transdifferentiation of mouse aortic smooth muscle cells to a macrophage-like state after cholesterol loading James X. Rong, Mark Shapiro, Eugene Trogan, and Edward A. Fisher PMCID: PMC263848 Protein profiles associated with survival in lung adenocarcinoma Guoan Chen, Tarek G Gharib, Hong Wang, Chiang-Ching Huang, Rork Kuick, Dafydd G. Thomas, Kerby A. Shedden, David E. Misek, Jeremy M. G. Taylor, Thomas J. Giordano, Sharon L. R. Kardia, Mark D. Iannettoni, John Yee, Philip J. Hogg, Mark B. Orringer, Samir M. Hanash, and David G. Beer PMCID: PMC263849 Id-1 as a molecular target in therapy for breast cancer cell invasion and metastasis Sylvia Fong, Yoko Itahana, Tomoki Sumida, Jarnail Singh, Jean-Philippe Coppe, Yong Liu, Peter C. Richards, James L. Bennington, Nancy M. Lee, Robert J. Debs, and Pierre-Yves Desprez PMCID: PMC263850 Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance L. R. Hirsch, R. J. Stafford, J. A. Bankson, S. R. Sershen, B. Rivera, R. E. Price, J. D. Hazle, N. J. Halas, and J. L. West PMCID: PMC263851 PA-457: A potent HIV inhibitor that disrupts core condensation by targeting a late step in Gag processing F. Li, R. Goila-Gaur, K. Salzwedel, N. R. Kilgore, M. Reddick, C. Matallana, A. Castillo, D. Zoumplis, D. E. Martin, J. M. Orenstein, G. P. Allaway, E. O. Freed, and C. T. Wild PMCID: PMC263852 Identification and characterization of a cyclooxygenase-like enzyme from Entamoeba histolytica Indranil Dey, Kathy Keller, Adam Belley, and Kris Chadee PMCID: PMC263853 Refractory nature of normal human diploid fibroblasts with respect to oncogene-mediated transformation Tsuyoshi Akagi, Ken Sasai, and Hidesaburo Hanafusa PMCID: PMC263854 Differential effects on bone of estrogen receptor α and androgen receptor activation in orchidectomized adult male mice Sofia Movérare, Katrien Venken, Anna-Lena Eriksson, Niklas Andersson, Stanko Skrtic, Jon Wergedal, Subburaman Mohan, Phil Salmon, Roger Bouillon, Jan-Åke Gustafsson, Dirk Vanderschueren, and Claes Ohlsson PMCID: PMC263855 Microbiology Extensive repetitive DNA facilitates prokaryotic genome plasticity Rahul A. Aras, Josephine Kang, Ariane I. Tschumi, Yasuaki Harasaki, and Martin J. Blaser PMCID: PMC263856 Reevaluation of human cytomegalovirus coding potential Eain Murphy, Isidore Rigoutsos, Tetsuo Shibuya, and Thomas E. Shenk PMCID: PMC263857 Discovery of a bacterium, with distinctive dioxygenase, that is responsible for in situ biodegradation in contaminated sediment C. O. Jeon, W. Park, P. Padmanabhan, C. DeRito, J. R. Snape, and E. L. Madsen PMCID: PMC263858 Multiple oscillators regulate circadian gene expression in Neurospora Alejandro Correa, Zachary A. Lewis, Andrew V. Greene, Irene J. March, Richard H. Gomer, and Deborah Bell-Pedersen PMCID: PMC263859 Spx-dependent global transcriptional control is induced by thiol-specific oxidative stress in Bacillus subtilis Shunji Nakano, Elke Küster-Schöck, Alan D. Grossman, and Peter Zuber PMCID: PMC263860 Neuroscience Aquaporin-4 square array assembly: Opposing actions of M1 and M23 isoforms C. Sue Furman, Daniel A. Gorelick-Feldman, Kimberly G. V. Davidson, Thomas Yasumura, John D. Neely, Peter Agre, and John E. Rash PMCID: PMC263861 Delayed K+ clearance associated with aquaporin-4 mislocalization: Phenotypic defects in brains of α-syntrophin-null mice Mahmood Amiry-Moghaddam, Anne Williamson, Maria Palomba, Tore Eid, Nihal C. de Lanerolle, Erlend A. Nagelhus, Marvin E. Adams, Stanley C. Froehner, Peter Agre, and Ole P. Ottersen PMCID: PMC263862 Botulinum toxin type B micromechanosensor W. Liu, Vedrana Montana, Edwin R. Chapman, U. Mohideen, and Vladimir Parpura PMCID: PMC263863 From the Cover:
An emotion-induced retrograde amnesia in humans is amygdala- and β-adrenergic-dependent B. A. Strange, R. Hurlemann, and R. J. Dolan PMCID: PMC263864 Inflammation is detrimental for neurogenesis in adult brain Christine T. Ekdahl, Jan-Hendrik Claasen, Sara Bonde, Zaal Kokaia, and Olle Lindvall PMCID: PMC263865 Interaction of sensory responses with spontaneous depolarization in layer 2/3 barrel cortex Carl C. H. Petersen, Thomas T. G. Hahn, Mayank Mehta, Amiram Grinvald, and Bert Sakmann PMCID: PMC263866 Pannexins, a family of gap junction proteins expressed in brain Roberto Bruzzone, Sheriar G. Hormuzdi, Michael T. Barbe, Anne Herb, and Hannah Monyer PMCID: PMC263867 Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease Patrice D. Smith, Stephen J. Crocker, Vernice Jackson-Lewis, Kelly L. Jordan-Sciutto, Shawn Hayley, Matthew P. Mount, Michael J. O'Hare, Steven Callaghan, Ruth S. Slack, Serge Przedborski, Hymie Anisman, and David S. Park PMCID: PMC263868 Essential role for RGS9 in opiate action Venetia Zachariou, Dan Georgescu, Nick Sanchez, Zia Rahman, Ralph DiLeone, Olivier Berton, Rachael L. Neve, Laura J. Sim-Selley, Dana E. Selley, Stephen J. Gold, and Eric J. Nestler PMCID: PMC263869 Isorhodopsin rather than rhodopsin mediates rod function in RPE65 knock-out mice Jie Fan, Baerbel Rohrer, Gennadiy Moiseyev, Jian-xing Ma, and Rosalie K. Crouch PMCID: PMC263870 Allosteric modulation of group III metabotropic glutamate receptor 4: A potential approach to Parkinson's disease treatment Michael J. Marino, David L. Williams, Jr., Julie A. O'Brien, Ornella Valenti, Terrence P. McDonald, Michelle K. Clements, Ruiping Wang, Anthony G. DiLella, J. Fred Hess, Gene G. Kinney, and P. Jeffrey Conn PMCID: PMC263871 N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl-d-aspartate receptor activity Cyrille Sur, Pierre J. Mallorga, Marion Wittmann, Marlene A. Jacobson, Danette Pascarella, Jacinta B. Williams, Philip E. Brandish, Douglas J. Pettibone, Edward M. Scolnick, and P. Jeffrey Conn PMCID: PMC263872 Axonal transport of eukaryotic translation elongation factor 1α mRNA couples transcription in the nucleus to long-term facilitation at the synapse Maurizio Giustetto, Ashok N. Hegde, Kausik Si, Andrea Casadio, Kaoru Inokuchi, Wanzheng Pei, Eric R. Kandel, and James H. Schwartz PMCID: PMC263873 Pharmacology Reciprocal modulation of phospholipase Cβ isoforms: Adaptation to chronic morphine Sumita Chakrabarti, Nai-Jiang Liu, and Alan R. Gintzler PMCID: PMC263874 Physiology The low gonadotropin-independent constitutive production of testicular testosterone is sufficient to maintain spermatogenesis Fu-Ping Zhang, Tomi Pakarainen, Matti Poutanen, Jorma Toppari, and Ilpo Huhtaniemi PMCID: PMC263875 Abnormal osmotic regulation in trpv4-/- mice Wolfgang Liedtke and Jeffrey M. Friedman PMCID: PMC263876 Hyposulfatemia, growth retardation, reduced fertility, and seizures in mice lacking a functional NaSi-1 gene Paul A. Dawson, Laurent Beck, and Daniel Markovich PMCID: PMC263877 A panoramic view of gene expression in the human kidney Danielle Chabardès-Garonne, Arnaud Méjean, Jean-Christophe Aude, Lydie Cheval, Antonio Di Stefano, Marie-Claude Gaillard, Martine Imbert-Teboul, Monika Wittner, Chanth Balian, Véronique Anthouard, Catherine Robert, Béatrice Ségurens, Patrick Wincker, Jean Weissenbach, Alain Doucet, and Jean-Marc Elalouf PMCID: PMC263878 Calcium-dependent molecular spring elements in the giant protein titin Dietmar Labeit, Kaori Watanabe, Christian Witt, Hideaki Fujita, Yiming Wu, Sunshine Lahmers, Theodor Funck, Siegfried Labeit, and Henk Granzier PMCID: PMC263879 Population Biology INAUGURAL ARTICLE by a Recently Elected Academy Member: Estimating mean lifetime John Bongaarts and Griffith Feeney PMCID: PMC263728 Psychology Conscious and subliminal conflicts in normal subjects and patients with schizophrenia: The role of the anterior cingulate Stanislas Dehaene, Eric Artiges, Lionel Naccache, Catherine Martelli, Armelle Viard, Franck Schürhoff, Christophe Recasens, Marie Laure Paillère Martinot, Marion Leboyer, and Jean-Luc Martinot PMCID: PMC263880 Neural correlates of training-related memory improvement in adulthood and aging Lars Nyberg, Johan Sandblom, Sari Jones, Anna Stigsdotter Neely, Karl Magnus Petersson, Martin Ingvar, and Lars Bäckman PMCID: PMC263881 Correction Proc Natl Acad Sci U S A. 2003 November 11; 100(23): 13734–13735. doi: 10.1073/pnas.2336144100.PMCID: PMC263882 Corrects: Fuqiang Xu, et al. Odor maps of aldehydes and esters revealed by functional MRI in the glomerular layer of the mouse olfactory bulb. Proc Natl Acad Sci U S A. 2003 September 16; 100(19): 11029–11034. |
