| | This journal provides immediate access to some articles. Commentaries Genetic manipulation of vectors: A potential novel approach for
control of vector-borne diseases Barry J Beaty PMCID: PMC34037 Reengineering the glutathione S-transferase
scaffold: A rational design strategy pays off Patricia C. Babbitt PMCID: PMC34038 Heparin sequencing brings structure to the function of complex
oligosaccharides Matthew A. Nugent PMCID: PMC34039 Human forcing of climate change: Easing up on the gas pedal Ralph J. Cicerone PMCID: PMC34040 Physical Sciences Chemistry Peroxynitrite does not decompose to singlet oxygen
(1ΔgO2) and
nitroxyl (NO−) Glaucia R. Martinez, Paolo Di Mascio, Marcelo G. Bonini, Ohara Augusto, Karlis Briviba, Helmut Sies, Patrick Maurer, Ursula Röthlisberger, Susanna Herold, and Willem H. Koppenol PMCID: PMC27019 Automated de novo sequencing of proteins by tandem high-resolution mass spectrometry David M. Horn, Roman A. Zubarev, and Fred W. McLafferty PMCID: PMC27020 From the Cover:
Nanoscale imaging of chemical interactions: Fluorine on graphite Kevin F. Kelly, Edward T. Mickelson, Robert H. Hauge, John L. Margrave, and Naomi J. Halas PMCID: PMC27021 Statistics The importance of being discrete: Life always wins on the surface Nadav M. Shnerb, Yoram Louzoun, Eldad Bettelheim, and Sorin Solomon PMCID: PMC27022 Biological Sciences Agricultural Sciences Cattle lack vascular receptors for Escherichia coli O157:H7 Shiga toxins Ingrid M. Pruimboom-Brees, Tim W. Morgan, Mark R. Ackermann, Evelyn D. Nystrom, James E. Samuel, Nancy A. Cornick, and Harley W. Moon PMCID: PMC27023 Biochemistry Peroxynitrite does not decompose to singlet oxygen
(1ΔgO2) and
nitroxyl (NO−) Glaucia R. Martinez, Paolo Di Mascio, Marcelo G. Bonini, Ohara Augusto, Karlis Briviba, Helmut Sies, Patrick Maurer, Ursula Röthlisberger, Susanna Herold, and Willem H. Koppenol PMCID: PMC27019 Identification of a nuclear domain with deacetylase activity Michael Downes, Peter Ordentlich, Hung-Ying Kao, Jacqueline G. A. Alvarez, and Ronald M. Evans PMCID: PMC27024 Critical roles of glycosylphosphatidylinositol for Trypanosoma brucei Kisaburo Nagamune, Tomoyoshi Nozaki, Yusuke Maeda, Kazuhito Ohishi, Toshihide Fukuma, Tatsuru Hara, Ralph T. Schwarz, Christine Sütterlin, Reto Brun, Howard Riezman, and Taroh Kinoshita PMCID: PMC27025 Cellulose-binding domains promote hydrolysis of different sites on crystalline cellulose Géraldine Carrard, Anu Koivula, Hans Söderlund, and Pierre Béguin PMCID: PMC27026 Identification and characterization of a mammalian protein interacting with 20S proteasome precursors Lena Burri, Jörg Höckendorff, Ulrich Boehm, Thorsten Klamp, R. Jürgen Dohmen, and Frédéric Lévy PMCID: PMC27027 NMR reveals hydrogen bonds between oxygen and distal histidines in oxyhemoglobin Jonathan A. Lukin, Virgil Simplaceanu, Ming Zou, Nancy T. Ho, and Chien Ho PMCID: PMC27028 From the Cover:
Sequencing of 3-O sulfate containing heparin decasaccharides with a partial antithrombin III binding site Zachary Shriver, Rahul Raman, Ganesh Venkataraman, Katherine Drummond, Jeremy Turnbull, Toshihiko Toida, Robert Linhardt, Klaus Biemann, and Ram Sasisekharan PMCID: PMC27029 Cleavage of the antithrombin III binding site in heparin by heparinases and its implication in the generation of low molecular weight heparin Zachary Shriver, Mallikarjun Sundaram, Ganesh Venkataraman, Jawed Fareed, Robert Linhardt, Klaus Biemann, and Ram Sasisekharan PMCID: PMC27030 Unusual 1H NMR chemical shifts support (His) C ![[var epsilon]](corehtml/pmc/pmcents/epsiv.gif) 1—H ![[center dot]](corehtml/pmc/pmcents/middot.gif) O==C H-bond: Proposal for reaction-driven ring flip mechanism in serine protease catalysis Elissa L. Ash, James L. Sudmeier, Regina M. Day, Matthew Vincent, Ekaterina V. Torchilin, Kristin Coffman Haddad, Elizabeth M. Bradshaw, David G. Sanford, and William W. Bachovchin PMCID: PMC27031 Biophysics Simultaneous two-photon excitation of distinct labels for dual-color fluorescence crosscorrelation analysis Katrin G. Heinze, Andre Koltermann, and Petra Schwille PMCID: PMC27032 Native protein sequences are close to optimal for their structures Brian Kuhlman and David Baker PMCID: PMC27033 Cell Biology Ataxia telangiectasia-mutated phosphorylates Chk2 in
vivo and in vitro Shuhei Matsuoka, Galit Rotman, Akira Ogawa, Yosef Shiloh, Katsuyuki Tamai, and Stephen J. Elledge PMCID: PMC27034 Molecular basis for CD40 signaling mediated by TRAF3 Chao-Zhou Ni, Kate Welsh, Eugen Leo, Chu-kuan Chiou, Hao Wu, John C. Reed, and Kathryn R. Ely PMCID: PMC27035 Anterograde flow of cargo across the Golgi stack potentially mediated via bidirectional “percolating” COPI vesicles Lelio Orci, Mariella Ravazzola, Allen Volchuk, Thomas Engel, Michael Gmachl, Mylène Amherdt, Alain Perrelet, Thomas H. Söllner, and James E. Rothman PMCID: PMC27036 Functional interaction between c-Jun and promoter factor Sp1 in epidermal growth factor-induced gene expression of human 12(S)-lipoxygenase Ben-Kuen Chen and Wen-Chang Chang PMCID: PMC27037 DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells Nargis Nasrin, Scott Ogg, Catherine M. Cahill, William Biggs, Simin Nui, Justin Dore, Dominica Calvo, Yang Shi, Gary Ruvkun, and Maria C. Alexander-Bridges PMCID: PMC27038 Nucleocytoplasmic translocation of Stat1 is regulated by a leucine-rich export signal in the coiled-coil domain Andreas Begitt, Thomas Meyer, Marleen van Rossum, and Uwe Vinkemeier PMCID: PMC27039 Identification of diverse nerve growth factor-regulated genes by serial analysis of gene expression (SAGE) profiling James M. Angelastro, Lars Klimaschewski, Song Tang, Ottavio V. Vitolo, Tamily A. Weissman, Laura T. Donlin, Michael L. Shelanski, and Lloyd A. Greene PMCID: PMC27040 Activation of HIF1α ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex Takumi Kamura, Shigeo Sato, Kazuhiro Iwai, Maria Czyzyk-Krzeska, Ronald C. Conaway, and Joan Weliky Conaway PMCID: PMC27041 Developmental Biology A genomewide survey of basic helix–loop–helix factors in Drosophila Adrian W. Moore, Sandra Barbel, Lily Yeh Jan, and Yuh Nung Jan PMCID: PMC27042 Portosystemic shunting and persistent fetal vascular structures in aryl hydrocarbon receptor-deficient mice Garet P. Lahvis, Susanne L. Lindell, Russell S. Thomas, Robert S. McCuskey, Christopher Murphy, Edward Glover, Michael Bentz, James Southard, and Christopher A. Bradfield PMCID: PMC27043 A model for individual and collective cell movement in Dictyostelium discoideum Eirikur Palsson and Hans G. Othmer PMCID: PMC27044 Essential role for p38α mitogen-activated protein kinase in placental angiogenesis John S. Mudgett, Jixiang Ding, Lucia Guh-Siesel, Nicole A. Chartrain, Lu Yang, Shobhna Gopal, and Michael M. Shen PMCID: PMC27045 Evolution From the Cover:
Sexual conflict promotes speciation in insects Göran Arnqvist, Martin Edvardsson, Urban Friberg, and Tina Nilsson PMCID: PMC27046 Mutators and sex in bacteria: Conflict between adaptive strategies Olivier Tenaillon, Hervé Le Nagard, Bernard Godelle, and François Taddei PMCID: PMC27047 Genetics Rapid generation of nested chromosomal deletions on mouse chromosome 2 David F. LePage, Deanna M. Church, Elise Millie, Terry J. Hassold, and Ronald A. Conlon PMCID: PMC27048 Replication-dependent early meiotic requirement for Spo11 and Rad50 Sandra T. Merino, W. Jason Cummings, Sonia N. Acharya, and Miriam E. Zolan PMCID: PMC27049 Complex promoter and coding region β2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness Connie M. Drysdale, Dennis W. McGraw, Catharine B. Stack, J. Claiborne Stephens, Richard S. Judson, Krishnan Nandabalan, Kevin Arnold, Gualberto Ruano, and Stephen B. Liggett PMCID: PMC27050 Act1, an NF-κB-activating protein Xiaoxia Li, Mairead Commane, Huiqin Nie, Xianxin Hua, Moitreyee Chatterjee-Kishore, David Wald, Michael Haag, and George R. Stark PMCID: PMC27051 CIKS, a connection to IκB kinase and stress-activated protein kinase Antonio Leonardi, Alain Chariot, Estefania Claudio, Kirk Cunningham, and Ulrich Siebenlist PMCID: PMC27052 Parent–progeny recognition as a function of MHC odortype identity K. Yamazaki, G. K. Beauchamp, M. Curran, J. Bard, and E. A. Boyse PMCID: PMC27053 UV-induced inhibition of transcription involves repression of transcription initiation and phosphorylation of RNA polymerase II Davy A. P. Rockx, Rebecca Mason, Anneke van Hoffen, Michelle Craig Barton, Elisabetta Citterio, David B. Bregman, Albert A. van Zeeland, Harry Vrieling, and Leon H. F. Mullenders PMCID: PMC27054 Immunology IL-4 and -5 prime human mast cells for different profiles of IgE-dependent cytokine production Hiroshi Ochi, Nidia H. De Jesus, Fred H. Hsieh, K. Frank Austen, and Joshua A. Boyce PMCID: PMC27055 Differential requirement of the cytoplasmic subregions of γc chain in T cell development and function Shiho Tsujino, James P. Di Santo, Akinori Takaoka, Teresa L. McKernan, Shigeru Noguchi, Choji Taya, Hiromichi Yonekawa, Takashi Saito, Tadatsugu Taniguchi, and Hodaka Fujii PMCID: PMC27056 From the Cover:
Toll-related receptors and the control of antimicrobial peptide
expression in Drosophila Servane Tauszig, Emmanuelle Jouanguy, Jules A. Hoffmann, and Jean-Luc Imler PMCID: PMC27057 Medical Sciences From the Cover:
Erythropoietin crosses the blood–brain barrier to protect against experimental brain injury Michael L. Brines, Pietro Ghezzi, Sonja Keenan, Davide Agnello, Nihal C. de Lanerolle, Carla Cerami, Loretta M. Itri, and Anthony Cerami PMCID: PMC27058 A distinctive clade B HIV type 1 is heterosexually transmitted in Trinidad and Tobago F. R. Cleghorn, N. Jack, J. K. Carr, J. Edwards, B. Mahabir, A. Sill, C. B. McDanal, S. M. Connolly, D. Goodman, R. Q. Bennetts, T. R. O'Brien, K. J. Weinhold, C. Bartholomew, W. A. Blattner, and M. L. Greenberg PMCID: PMC27059 Abnormal integrin-mediated regulation of chronic myelogenous leukemia CD34+ cell proliferation: BCR/ABL up-regulates the cyclin-dependent kinase inhibitor, p27Kip, which is relocated to the cell cytoplasm and incapable of regulating cdk2 activity Yuehua Jiang, Robert C. H. Zhao, and Catherine M. Verfaillie PMCID: PMC27060 Overexpression of MYC causes p53-dependent G2 arrest of normal fibroblasts Dean W. Felsher, Anders Zetterberg, Jiyue Zhu, Thea Tlsty, and J. Michael Bishop PMCID: PMC27061 A RUNX2/PEBP2αA/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia Yu-Wen Zhang, Natsuo Yasui, Kosei Ito, Gang Huang, Makiko Fujii, Jun-ichi Hanai, Hiroshi Nogami, Takahiro Ochi, Kohei Miyazono, and Yoshiaki Ito PMCID: PMC27062 Human renal cell carcinoma expresses distinct binding sites for growth hormone-releasing hormone Gabor Halmos, Andrew V. Schally, Jozsef L. Varga, Artur Plonowski, Zoltan Rekasi, and Tamas Czompoly PMCID: PMC27063 Isolation and sequencing of cDNAs for splice variants of growth hormone-releasing hormone receptors from human cancers Zoltan Rekasi, Tamas Czompoly, Andrew V. Schally, and Gabor Halmos PMCID: PMC27064 Microbiology Multiple independent origins of Shigella clones of
Escherichia coli and convergent evolution
of many of their characteristics Gulietta M. Pupo, Ruiting Lan, and Peter R. Reeves PMCID: PMC27065 Mapping the parameters of prion-induced neuropathology Michael P. H. Stumpf and David C. Krakauer PMCID: PMC27066 Experimental infection model for Sin Nombre hantavirus in the deer mouse (Peromyscus maniculatus) Jason Botten, Katy Mirowsky, Donna Kusewitt, Mausumi Bharadwaj, Joyce Yee, Roy Ricci, Richard M. Feddersen, and Brian Hjelle PMCID: PMC27067 Neurobiology Agmatine reverses pain induced by inflammation, neuropathy, and spinal cord injury Carolyn A. Fairbanks, Kristin L. Schreiber, Kori L. Brewer, Chen-Guang Yu, Laura S. Stone, Kelley F. Kitto, H. Oanh Nguyen, Brent M. Grocholski, Don W. Shoeman, Lois J. Kehl, Soundararajan Regunathan, Donald J. Reis, Robert P. Yezierski, and George L. Wilcox PMCID: PMC27068 Cortical processing of change detection: Dissociation between natural vowels and two-frequency complex tones Minna Vihla, Olli V. Lounasmaa, and Riitta Salmelin PMCID: PMC27069 A cGMP-signaling pathway in a subset of olfactory sensory neurons Mike R. Meyer, Albert Angele, Elisabeth Kremmer, U. Benjamin Kaupp, and Frank Müller PMCID: PMC27070 Assessment and discrimination of odor stimuli in rat olfactory bulb by dynamic functional MRI Fuqiang Xu, Ikuhiro Kida, Fahmeed Hyder, and Robert G. Shulman PMCID: PMC27071 Physiology Mitochondrial control of calcium-channel gating: A mechanism for sustained signaling and transcriptional activation in T lymphocytes Markus Hoth, Donald C. Button, and Richard S. Lewis PMCID: PMC27072 A common polymorphism associated with antibiotic-induced cardiac arrhythmia Federico Sesti, Geoffrey W. Abbott, Jian Wei, Katherine T. Murray, Sanjeev Saksena, Peter J. Schwartz, Silvia G. Priori, Dan M. Roden, Alfred L. George, Jr., and Steve A. N. Goldstein PMCID: PMC27073 Nutritional regulation of the fatty acid synthase promoter in vivo: Sterol regulatory element binding protein functions through an upstream region containing a sterol regulatory element Maria-Jesus Latasa, Yang Soo Moon, Kee-Hong Kim, and Hei Sook Sul PMCID: PMC27074 Plant Biology The Arabidopsis male-sterile mutant, opr3, lacks the 12-oxophytodienoic acid reductase required for jasmonate synthesis Annick Stintzi and John Browse PMCID: PMC27075 Phase identity of the maize leaf is determined after leaf initiation Joseph A. J. Orkwiszewski and R. Scott Poethig PMCID: PMC27076 Expression and parent-of-origin effects for FIS2, MEA, and FIE in the endosperm and embryo of developing Arabidopsis seeds Ming Luo, Pierre Bilodeau, Elizabeth S. Dennis, W. James Peacock, and Abed Chaudhury PMCID: PMC27077 A calcium influx is triggered and propagates in the zygote as a wavefront during in vitro fertilization of flowering plants A. F. Antoine, J.-E. Faure, S. Cordeiro, C. Dumas, M. Rougier, and J. A. Feijó PMCID: PMC27078 DGD1-independent biosynthesis of extraplastidic galactolipids after phosphate deprivation in Arabidopsis Heiko Härtel, Peter Dörmann, and Christoph Benning PMCID: PMC27079 Requirement of phosphatidylglycerol for photosynthetic function in thylakoid membranes Norihiro Sato, Miki Hagio, Hajime Wada, and Mikio Tsuzuki PMCID: PMC27080 Population Biology The importance of being discrete: Life always wins on the surface Nadav M. Shnerb, Yoram Louzoun, Eldad Bettelheim, and Sorin Solomon PMCID: PMC27022 Psychology Diffusion of nitric oxide can facilitate cerebellar learning: A
simulation study Nicolas Schweighofer and Gabriel Ferriol PMCID: PMC27081 Social Sciences Anthropology Early human occupation of Western Europe: Paleomagnetic dates for two paleolithic sites in Spain O. Oms, J. M. Parés, B. Martínez-Navarro, J. Agustí, I. Toro, G. Martínez-Fernández, and A. Turq PMCID: PMC27082 Corrections Proc Natl Acad Sci U S A. 2000 September 12; 97(19): 10671. PMCID: PMC56086 Corrects: Martin Krüger, et al. Identification of eIF2Bγ and eIF2γ as cofactors of hepatitis C virus internal ribosome entry site-mediated translation using a functional genomics approach. Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8566–8571. Proc Natl Acad Sci U S A. 2000 September 12; 97(19): 10671. PMCID: PMC56087 Corrects: Yukari C. Manabe, et al. Attenuation of virulence in Mycobacterium tuberculosis expressing a constitutively active iron repressor. Proc Natl Acad Sci U S A. 1999 October 26; 96(22): 12844–12848. |
