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Volume 97(15);  July 18, 2000
Commentaries
HIV therapy: Managing resistance
Dominik Wodarz and Martin A. Nowak
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8193–8195.
PMCID: PMC34002
Neural circuits in the 21st century: Synaptic networks of neurons and glia
Joseph J. LoTurco
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8196–8197.
PMCID: PMC34003
Bt corn pollen impacts on nontarget Lepidoptera: Assessment of effects in nature
David S. Pimentel and Peter H. Raven
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8198–8199.
PMCID: PMC34004
Physical Sciences
Applied Mathematics
Generalized flows, intrinsic stochasticity, and turbulent transport
Weinan E Vanden Eijnden and Eric Vanden Eijnden
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8200–8205.
PMCID: PMC26923
The paradox of alloreactivity and self MHC restriction: Quantitative analysis and statistics
Vincent Detours and Alan S. Perelson
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8479–8483.
PMCID: PMC26973
Applied Physical Sciences
Fluorescence microscopy with diffraction resolution barrier broken by stimulated emission
Thomas A. Klar, Stefan Jakobs, Marcus Dyba, Alexander Egner, and Stefan W. Hell
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8206–8210.
PMCID: PMC26924
Compact stellarators with modular coils
P. R. Garabedian
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8211–8215.
PMCID: PMC26925
Chemistry
The decomposition of peroxynitrite does not yield nitroxyl anion and singlet oxygen
Gábor Merényi, Johan Lind, Gidon Czapski, and Sara Goldstein
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8216–8218. Published online 2000 July 4.
PMCID: PMC26926
Two-dimensional infrared spectroscopy of peptides by phase-controlled femtosecond vibrational photon echoes
M. C. Asplund, M. T. Zanni, and R. M. Hochstrasser
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8219–8224. Published online 2000 July 11.
PMCID: PMC26927
Microtubule self-organization is gravity-dependent
Cyril Papaseit, Nathalie Pochon, and James Tabony
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8364–8368. Published online 2000 July 4.
PMCID: PMC26953
Biological Sciences
Anthropology
Polynesian origins: Insights from the Y chromosome
Bing Su, Li Jin, Peter Underhill, Jeremy Martinson, Nilmani Saha, Stephen T. McGarvey, Mark D. Shriver, Jiayou Chu, Peter Oefner, Ranajit Chakraborty, and Ranjan Deka
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8225–8228.
PMCID: PMC26928
Applied Biological Sciences
A repressible female-specific lethal genetic system for making transgenic insect strains suitable for a sterile-release program
Jörg C. Heinrich and Maxwell J. Scott
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8229–8232. Published online 2000 July 11.
PMCID: PMC26929
Biochemistry
Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: A model for viral DNA binding
Julian C.-H. Chen, Jolanta Krucinski, Larry J. W. Miercke, Janet S. Finer-Moore, Ann H. Tang, Andrew D. Leavitt, and Robert M. Stroud
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8233–8238. Published online 2000 July 11.
PMCID: PMC26930
A deoxyribonucleotidase in mitochondria: Involvement in regulation of dNTP pools and possible link to genetic disease
Chiara Rampazzo, Lisa Gallinaro, Eva Milanesi, Elisabetta Frigimelica, Peter Reichard, and Vera Bianchi
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8239–8244.
PMCID: PMC26931
Structure–activity analysis of buforin II, a histone H2A-derived antimicrobial peptide: The proline hinge is responsible for the cell-penetrating ability of buforin II
Chan Bae Park, Kwan-Su Yi, Katsumi Matsuzaki, Mi Sun Kim, and Sun Chang Kim
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8245–8250. Published online 2000 July 11.
PMCID: PMC26932
Biosynthesis of terpenoids: 4-Diphosphocytidyl-2-C-methyl-d-erythritol kinase from tomato
Felix Rohdich, Juraithip Wungsintaweekul, Holger Lüttgen, Markus Fischer, Wolfgang Eisenreich, Christoph A. Schuhr, Monika Fellermeier, Nicholas Schramek, Meinhart H. Zenk, and Adelbert Bacher
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8251–8256. Published online 2000 July 4.
PMCID: PMC26933
Crystal structure of the Holliday junction DNA in complex with a single RuvA tetramer
Mariko Ariyoshi, Tatsuya Nishino, Hiroshi Iwasaki, Hideo Shinagawa, and Kosuke Morikawa
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8257–8262. Published online 2000 July 11.
PMCID: PMC26934
m5C RNA and m5C DNA methyl transferases use different cysteine residues as catalysts
Yaoquan Liu and Daniel V. Santi
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8263–8265.
PMCID: PMC26935
Memory landscapes of single-enzyme molecules
Lars Edman and Rudolf Rigler
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8266–8271. Published online 2000 July 4.
PMCID: PMC26936
From the Cover:
Sensitive detection of DNA polymorphisms by the serial invasive signal amplification reaction
Jeff G. Hall, Peggy S. Eis, Scott M. Law, Luis P. Reynaldo, James R. Prudent, David J. Marshall, Hatim T. Allawi, Andrea L. Mast, James E. Dahlberg, Robert W. Kwiatkowski, Monika de Arruda, Bruce P. Neri, and Victor I. Lyamichev
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8272–8277. Published online 2000 July 11.
PMCID: PMC26937
A cytotoxic ribonuclease which specifically cleaves four isoaccepting arginine tRNAs at their anticodon loops
Kozo Tomita, Tetsuhiro Ogawa, Takeshi Uozumi, Kimitsuna Watanabe, and Haruhiko Masaki
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8278–8283. Published online 2000 July 4.
PMCID: PMC26938
Identification and characterization of an enzyme involved in the elongation of n-6 and n-3 polyunsaturated fatty acids
Jennifer M. Parker-Barnes, Tapas Das, Emil Bobik, Amanda E. Leonard, Jennifer M. Thurmond, Lu-Te Chaung, Yung-Sheng Huang, and Pradip Mukerji
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8284–8289.
PMCID: PMC26939
Activation of polyamine catabolism in transgenic rats induces acute pancreatitis
Leena Alhonen, Jyrki J. Parkkinen, Tuomo Keinänen, Riitta Sinervirta, Karl-Heinz Herzig, and Juhani Jänne
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8290–8295. Published online 2000 July 4.
PMCID: PMC26940
A quantitative, high-throughput screen for protein stability
S. Ghaemmaghami, M. C. Fitzgerald, and T. G. Oas
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8296–8301. Published online 2000 July 11.
PMCID: PMC26941
Sustained activation of Ras/Raf/mitogen-activated protein kinase cascade by the tumor suppressor p53
Sam W. Lee, Li Fang, Makoto Igarashi, Toru Ouchi, Kun Ping Lu, and Stuart A. Aaronson
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8302–8305. Published online 2000 July 11.
PMCID: PMC26942
Biophysics
Two-dimensional infrared spectroscopy of peptides by phase-controlled femtosecond vibrational photon echoes
M. C. Asplund, M. T. Zanni, and R. M. Hochstrasser
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8219–8224. Published online 2000 July 11.
PMCID: PMC26927
Changes in brain cell shape create residual extracellular space volume and explain tortuosity behavior during osmotic challenge
Kevin C. Chen and Charles Nicholson
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8306–8311. Published online 2000 July 11.
PMCID: PMC26943
NMR investigation of ferricytochrome c unfolding: Detection of an equilibrium unfolding intermediate and residual structure in the denatured state
Brandy S. Russell, Rory Melenkivitz, and Kara L. Bren
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8312–8317. Published online 2000 July 4.
PMCID: PMC26944
Site-specific conformational determination in thermal unfolding studies of helical peptides using vibrational circular dichroism with isotopic substitution
R. A. G. D. Silva, Jan Kubelka, Petr Bour, Sean M. Decatur, and Timothy A. Keiderling
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8318–8323. Published online 2000 July 4.
PMCID: PMC26945
Temperature and length scale dependence of hydrophobic effects and their possible implications for protein folding
David M. Huang and David Chandler
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8324–8327. Published online 2000 July 11.
PMCID: PMC26946
Modeling the dynamics of human hair cycles by a follicular automaton
J. Halloy, B. A. Bernard, G. Loussouarn, and A. Goldbeter
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8328–8333.
PMCID: PMC26947
NMR structure of the bovine prion protein
Francisco López García, Ralph Zahn, Roland Riek, and Kurt Wüthrich
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8334–8339.
PMCID: PMC26948
NMR structures of three single-residue variants of the human prion protein
Luigi Calzolai, Dominikus A. Lysek, Peter Güntert, Christine von Schroetter, Roland Riek, Ralph Zahn, and Kurt Wüthrich
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8340–8345.
PMCID: PMC26949
Cell Biology
From the Cover:
Spermatogonial stem cell enrichment by multiparameter selection of mouse testis cells
Takashi Shinohara, Kyle E. Orwig, Mary R. Avarbock, and Ralph L. Brinster
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8346–8351.
PMCID: PMC26950
Phosphate is a specific signal for induction of osteopontin gene expression
George R. Beck, Jr., Brad Zerler, and Elizabeth Moran
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8352–8357. Published online 2000 July 11.
PMCID: PMC26951
Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-β and Wnt pathways
Etienne Labbé, Ainhoa Letamendia, and Liliana Attisano
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8358–8363. Published online 2000 July 11.
PMCID: PMC26952
Microtubule self-organization is gravity-dependent
Cyril Papaseit, Nathalie Pochon, and James Tabony
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8364–8368. Published online 2000 July 4.
PMCID: PMC26953
Localization of α1,3-fucosyltransferase VI in Weibel–Palade bodies of human endothelial cells
Silvia Schnyder-Candrian, Lubor Borsig, René Moser, and Eric G. Berger
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8369–8374.
PMCID: PMC26954
Dissecting the role of the Golgi complex and lipid rafts in biosynthetic transport of cholesterol to the cell surface
Sanna Heino, Sari Lusa, Pentti Somerharju, Christian Ehnholm, Vesa M. Olkkonen, and Elina Ikonen
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8375–8380. Published online 2000 July 11.
PMCID: PMC26955
Inhibition of proteasomal degradation by the Gly-Ala repeat of Epstein–Barr virus is influenced by the length of the repeat and the strength of the degradation signal
Nico P. Dantuma, Stijn Heessen, Kristina Lindsten, Marianne Jellne, and Maria G. Masucci
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8381–8385. Published online 2000 July 11.
PMCID: PMC26956
Developmental Biology
The transcription factor EPAS-1/hypoxia-inducible factor 2α plays an important role in vascular remodeling
Jun Peng, Liyong Zhang, Linsay Drysdale, and Guo-Hua Fong
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8386–8391. Published online 2000 July 4.
PMCID: PMC26957
Evolution
Interpreting the universal phylogenetic tree
Carl R. Woese
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8392–8396.
PMCID: PMC26958
Genetics
Transcription coupled repair of 8-oxoguanine in murine cells: The Ogg1 protein is required for repair in nontranscribed sequences but not in transcribed sequences
Florence Le Page, Arne Klungland, Deborah E. Barnes, Alain Sarasin, and Serge Boiteux
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8397–8402. Published online 2000 July 11.
PMCID: PMC26959
Distinct spectra of somatic mutations accumulated with age in mouse heart and small intestine
Martijn E. T. Dollé, Wendy K. Snyder, Jan A. Gossen, Paul H. M. Lohman, and Jan Vijg
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8403–8408.
PMCID: PMC26960
Fundamental patterns underlying gene expression profiles: Simplicity from complexity
Neal S. Holter, Madhusmita Mitra, Amos Maritan, Marek Cieplak, Jayanth R. Banavar, and Nina V. Fedoroff
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8409–8414. Published online 2000 July 11.
PMCID: PMC26961
Balancing transcriptional interference and initiation on the GAL7 promoter of Saccharomyces cerevisiae
Ingo H. Greger, Agustín Aranda, and Nick Proudfoot
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8415–8420. Published online 2000 July 11.
PMCID: PMC26962
A male germ cell tumor-susceptibility-determining locus, pgct1, identified on murine chromosome 13
Alexander J. Muller, Angelika K. Teresky, and Arnold J. Levine
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8421–8426. Published online 2000 July 11.
PMCID: PMC26963
Immunology
The role of antigen and IL-12 in sustaining Th1 memory cells in vivo: IL-12 is required to maintain memory/effector Th1 cells sufficient to mediate protection to an infectious parasite challenge
Laura Stobie, Sanjay Gurunathan, Calman Prussin, David L. Sacks, Nicolas Glaichenhaus, Chang-You Wu, and Robert A. Seder
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8427–8432. Published online 2000 July 11.
PMCID: PMC26964
Crystal structure of an anti-carbohydrate antibody directed against Vibrio cholerae O1 in complex with antigen: Molecular basis for serotype specificity
S. Villeneuve, H. Souchon, M.-M. Riottot, J.-C. Mazié, P.-s. Lei, C. P. J. Glaudemans, P. Kováč, J.-M. Fournier, and P. M. Alzari
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8433–8438. Published online 2000 July 4.
PMCID: PMC26965
Internalization of CD26 by mannose 6-phosphate/insulin-like growth factor II receptor contributes to T cell activation
Hideto Ikushima, Yasuhiko Munakata, Tomonori Ishii, Satoshi Iwata, Masazumi Terashima, Hirotoshi Tanaka, Stuart F. Schlossman, and Chikao Morimoto
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8439–8444.
PMCID: PMC26966
CD1c molecules broadly survey the endocytic system
Masahiko Sugita, Nicole van der Wel, Rick A. Rogers, Peter J. Peters, and Michael B. Brenner
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8445–8450. Published online 2000 July 11.
PMCID: PMC26967
The serine and threonine residues in the Ig-α cytoplasmic tail negatively regulate immunoreceptor tyrosine-based activation motif-mediated signal transduction
Ralph Müller, Jürgen Wienands, and Michael Reth
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8451–8454.
PMCID: PMC26968
Inhibition of MHC class I-restricted antigen presentation by γ2-herpesviruses
Philip G. Stevenson, Stacey Efstathiou, Peter C. Doherty, and Paul J. Lehner
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8455–8460. Published online 2000 July 11.
PMCID: PMC26969
α-Galactosylceramide-activated Vα14 natural killer T cells mediate protection against murine malaria
Gloria Gonzalez-Aseguinolaza, Camila de Oliveira, Margaret Tomaska, Seokmann Hong, Oscar Bruna-Romero, Toshinori Nakayama, Masaru Taniguchi, Albert Bendelac, Luc Van Kaer, Yasuhiko Koezuka, and Moriya Tsuji
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8461–8466.
PMCID: PMC26970
V(D)J recombination is not activated by demethylation of the kappa locus
Sara R. Cherry, Caroline Beard, Rudolf Jaenisch, and David Baltimore
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8467–8472. Published online 2000 July 4.
PMCID: PMC26971
Comparative T cell receptor repertoire selection by antigen after adoptive transfer: A glimpse at an antigen-specific preimmune repertoire
Valérie Attuil, Philipp Bucher, Mauricette Rossi, Mireille Mutin, and Janet L. Maryanski
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8473–8478.
PMCID: PMC26972
The paradox of alloreactivity and self MHC restriction: Quantitative analysis and statistics
Vincent Detours and Alan S. Perelson
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8479–8483.
PMCID: PMC26973
Medical Sciences
A peptide derived from the non-receptor-binding region of urokinase plasminogen activator inhibits glioblastoma growth and angiogenesis in vivo in combination with cisplatin
Kazuhiko Mishima, Andrew P. Mazar, Allen Gown, Marilyn Skelly, Xiang-Dong Ji, Xu-Dong Wang, Terence R. Jones, Webster K. Cavenee, and H.-J. Su Huang
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8484–8489. Published online 2000 July 11.
PMCID: PMC26974
Induction of wild-type p53 activity in human cancer cells by ribozymes that repair mutant p53 transcripts
Takashi Watanabe and Bruce A. Sullenger
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8490–8494. Published online 2000 July 11.
PMCID: PMC26975
High-resolution microPET imaging of carcinoembryonic antigen-positive xenografts by using a copper-64-labeled engineered antibody fragment
Anna M. Wu, Paul J. Yazaki, Shih-wa Tsai, Khoi Nguyen, Anne-Line Anderson, Deborah W. McCarthy, Michael J. Welch, John E. Shively, Lawrence E. Williams, Andrew A. Raubitschek, Jeffrey Y. C. Wong, Tatsushi Toyokuni, Michael E. Phelps, and Sanjiv S. Gambhir
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8495–8500. Published online 2000 July 4.
PMCID: PMC26976
Activation of p53 in cervical carcinoma cells by small molecules
Sakari Hietanen, Sonia Lain, Eberhard Krausz, Christine Blattner, and David P. Lane
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8501–8506.
PMCID: PMC26977
Elongin BC complex prevents degradation of von Hippel-Lindau tumor suppressor gene products
Alan R. Schoenfeld, Eliot J. Davidowitz, and Robert D. Burk
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8507–8512.
PMCID: PMC26978
LXRα functions as a cAMP-responsive transcriptional regulator of gene expression
Kouichi Tamura, Yuqing E. Chen, Masatsugu Horiuchi, Qin Chen, Laurent Daviet, Zhiyong Yang, Laurent Daviet, Marco Lopez-Ilasaca, Hui Mu, Richard E. Pratt, and Victor J. Dzau
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8513–8518. Published online 2000 July 11.
PMCID: PMC26979
Retinoic acid induces sodium/iodide symporter gene expression and radioiodide uptake in the MCF-7 breast cancer cell line
Takahiko Kogai, James J. Schultz, Laura S. Johnson, Min Huang, and Gregory A. Brent
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8519–8524. Published online 2000 July 11.
PMCID: PMC26980
Corin, a transmembrane cardiac serine protease, acts as a pro-atrial natriuretic peptide-converting enzyme
Wei Yan, Faye Wu, John Morser, and Qingyu Wu
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8525–8529. Published online 2000 July 4.
PMCID: PMC26981
Role of cysteines in Plasmodium falciparum circumsporozoite protein: Interactions with heparin can rejuvenate inactive protein mutants
Dharmendar Rathore and Thomas F. McCutchan
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8530–8535. Published online 2000 July 11.
PMCID: PMC26982
Leptin, troglitazone, and the expression of sterol regulatory element binding proteins in liver and pancreatic islets
Tetsuya Kakuma, Young Lee, Moritake Higa, Zhuo-wei Wang, Wentong Pan, Iichiro Shimomura, and Roger H. Unger
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8536–8541.
PMCID: PMC26983
Epidermal growth factor-induced nuclear factor κB activation: A major pathway of cell-cycle progression in estrogen-receptor negative breast cancer cells
Debajit K. Biswas, Antonio P. Cruz, Eva Gansberger, and Arthur B. Pardee
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8542–8547.
PMCID: PMC26984
Site-specific chemical modification with polyethylene glycol of recombinant immunotoxin anti-Tac(Fv)-PE38 (LMB-2) improves antitumor activity and reduces animal toxicity and immunogenicity
Yasuo Tsutsumi, Masanori Onda, Satoshi Nagata, Byungkook Lee, Robert J. Kreitman, and Ira Pastan
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8548–8553. Published online 2000 July 11.
PMCID: PMC26985
Microbiology
whmD is an essential mycobacterial gene required for proper septation and cell division
James E. Gomez and William R. Bishai
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8554–8559. Published online 2000 July 4.
PMCID: PMC26986
Genetic control of resistance to experimental infection with virulent Mycobacterium tuberculosis
Igor Kramnik, William F. Dietrich, Peter Demant, and Barry R. Bloom
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8560–8565. Published online 2000 July 11.
PMCID: PMC26987
Identification of eIF2Bγ and eIF2γ as cofactors of hepatitis C virus internal ribosome entry site-mediated translation using a functional genomics approach
Martin Krüger, Carmela Beger, Qiang-Xin Li, Peter J. Welch, Richard Tritz, Mark Leavitt, Jack R. Barber, and Flossie Wong-Staal
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8566–8571.
PMCID: PMC26988
CTX[var phi] contains a hybrid genome derived from tandemly integrated elements
Brigid M. Davis and Matthew K. Waldor
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8572–8577. Published online 2000 July 4.
PMCID: PMC26989
Neurobiology
Calcium imaging demonstrates colocalization of calcium influx and extrusion in fly photoreceptors
Johannes Oberwinkler and Doekele G. Stavenga
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8578–8583.
PMCID: PMC26990
A relationship between behavior, neurotrophin expression, and new neuron survival
Xiao-Ching Li, Erich D. Jarvis, Benjamin Alvarez-Borda, Daniel A. Lim, and Fernando Nottebohm
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8584–8589. Published online 2000 July 11.
PMCID: PMC26991
Calsenilin reverses presenilin-mediated enhancement of calcium signaling
Malcolm A. Leissring, Tritia R. Yamasaki, Wilma Wasco, Joseph D. Buxbaum, Ian Parker, and Frank M. LaFerla
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8590–8593.
PMCID: PMC26992
The γ-aminobutyric acid type A receptor (GABAAR)-associated protein GABARAP interacts with gephyrin but is not involved in receptor anchoring at the synapse
Matthias Kneussel, Silke Haverkamp, Jens C. Fuhrmann, Hongbing Wang, Heinz Wässle, Richard W. Olsen, and Heinrich Betz
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8594–8599.
PMCID: PMC26993
An initiator element mediates autologous downregulation of the human type A γ-aminobutyric acid receptor β1 subunit gene
Shelley J. Russek, Sabita Bandyopadhyay, and David H. Farb
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8600–8605.
PMCID: PMC26994
Dopamine D1 and adenosine A1 receptors form functionally interacting heteromeric complexes
Silvia Ginés, Joëlle Hillion, Maria Torvinen, Stèphane Le Crom, Vicent Casadó, Enric I. Canela, Sofia Rondin, Jow Y. Lew, Stanley Watson, Michele Zoli, Luigi Francesco Agnati, Philippe Vernier, Carmen Lluis, Sergi Ferré, Kjell Fuxe, and Rafael Franco
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8606–8611. Published online 2000 July 11.
PMCID: PMC26995
Reelin controls position of autonomic neurons in the spinal cord
Joseph W. Yip, Yee Ping L. Yip, Kazunori Nakajima, and Christine Capriotti
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8612–8616. Published online 2000 July 4.
PMCID: PMC26996
Dynamic regulation of neuronal NO synthase transcription by calcium influx through a CREB family transcription factor-dependent mechanism
Masayuki Sasaki, Mirella Gonzalez-Zulueta, Hui Huang, William J. Herring, Sohyun Ahn, David D. Ginty, Valina L. Dawson, and Ted M. Dawson
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8617–8622.
PMCID: PMC26997
Rapid restoration of visual pigment and function with oral retinoid in a mouse model of childhood blindness
J. Preston Van Hooser, Tomas S. Aleman, Yu-Guang He, Artur V. Cideciyan, Vladimir Kuksa, Steven J. Pittler, Edwin M. Stone, Samuel G. Jacobson, and Krzysztof Palczewski
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8623–8628. Published online 2000 June 27.
PMCID: PMC26998
From the Cover:
Physiological astrocytic calcium levels stimulate glutamate release to modulate adjacent neurons
Vladimir Parpura and Philip G. Haydon
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8629–8634.
PMCID: PMC26999
Quantification of spread of cerebellar long-term depression with chemical two-photon uncaging of glutamate
Samuel S.-H. Wang, Leonard Khiroug, and George J. Augustine
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8635–8640. Published online 2000 July 11.
PMCID: PMC27000
Pentameric assembly of a neuronal glutamate transporter
Sepehr Eskandari, Michael Kreman, Michael P. Kavanaugh, Ernest M. Wright, and Guido A. Zampighi
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8641–8646.
PMCID: PMC27001
Excess “read-through” acetylcholinesterase attenuates but the “synaptic” variant intensifies neurodeterioration correlates
Meira Sternfeld, Shai Shoham, Omer Klein, Cesar Flores-Flores, Tamah Evron, Gregory H. Idelson, Dani Kitsberg, James W. Patrick, and Hermona Soreq
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8647–8652. Published online 2000 July 11.
PMCID: PMC27002
Pharmacology
A role for Src kinase in spontaneous epileptiform activity in the CA3 region of the hippocampus
Pietro Paolo Sanna, Fulvia Berton, Maurizio Cammalleri, Melanie K. Tallent, George R. Siggins, Floyd E. Bloom, and Walter Francesconi
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8653–8657. Published online 2000 July 11.
PMCID: PMC27003
Fibroblast growth factors: An epigenetic mechanism of broad spectrum resistance to anticancer drugs
SaeHeum Song, M. Guillaume Wientjes, Yuebo Gan, and Jessie L.-S. Au
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8658–8663. Published online 2000 July 11.
PMCID: PMC27004
Physiology
γ-Aminobutyric acid type B receptors are expressed and functional in mammalian cardiomyocytes
Paco Lorente, Alain Lacampagne, Yvan Pouzeratte, Stephen Richards, Barbara Malitschek, Rainer Kuhn, Bernhard Bettler, and Guy Vassort
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8664–8669.
PMCID: PMC27005
Mitochondria as ATP consumers: Cellular treason in anoxia
Julie St-Pierre, Martin D. Brand, and Robert G. Boutilier
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8670–8674. Published online 2000 July 11.
PMCID: PMC27006
Regulation of CFTR Cl channel gating by ATP binding and hydrolysis
Mutsuhiro Ikuma and Michael J. Welsh
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8675–8680. Published online 2000 July 4.
PMCID: PMC27007
Acute systemic inflammation up-regulates secretory sphingomyelinase in vivo: A possible link between inflammatory cytokines and atherogenesis
Ma-Li Wong, Boxun Xie, Nan Beatini, Phan Phu, Sudhir Marathe, Anthony Johns, Philip W. Gold, Emmet Hirsch, Kevin Jon Williams, Julio Licinio, and Ira Tabas
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8681–8686. Published online 2000 July 11.
PMCID: PMC27008
Plant Biology
From the Cover:
Inositol hexakisphosphate is a physiological signal regulating the K+-inward rectifying conductance in guard cells
Fouad Lemtiri-Chlieh, Enid A. C. MacRobbie, and Charles A. Brearley
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8687–8692. Published online 2000 July 11.
PMCID: PMC27009
Calcium release from the endoplasmic reticulum of higher plants elicited by the NADP metabolite nicotinic acid adenine dinucleotide phosphate
Lorella Navazio, Michael A. Bewell, Ashia Siddiqua, George D. Dickinson, Antony Galione, and Dale Sanders
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8693–8698. Published online 2000 July 11.
PMCID: PMC27010
Transgenic potato (Solanum tuberosum) tubers synthesize the full spectrum of inulin molecules naturally occurring in globe artichoke (Cynara scolymus) roots
Elke M. Hellwege, Sylvia Czapla, Anuschka Jahnke, Lothar Willmitzer, and Arnd G. Heyer
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8699–8704. Published online 2000 July 11.
PMCID: PMC27011
Adenosine diphosphate glucose pyrophosphatase: A plastidial phosphodiesterase that prevents starch biosynthesis
Milagros Rodríguez-López, Edurne Baroja-Fernández, Aitor Zandueta-Criado, and Javier Pozueta-Romero
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8705–8710. Published online 2000 July 11.
PMCID: PMC27012
Enhancement of induced disease resistance by simultaneous activation of salicylate- and jasmonate-dependent defense pathways in Arabidopsis thaliana
Saskia C. M. van Wees, Erik A. M. de Swart, Johan A. van Pelt, Leendert C. van Loon, and Corné M. J. Pieterse
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8711–8716. Published online 2000 July 11.
PMCID: PMC27013
An ethylene-induced cDNA encoding a lipase expressed at the onset of senescence
Yuwen Hong, Tzann-Wei Wang, Katalin A. Hudak, Frank Schade, Carol D. Froese, and John E. Thompson
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8717–8722. Published online 2000 July 11.
PMCID: PMC27014
Psychology
Orbitofrontal cortex: A key prefrontal region for encoding information
Stephen Frey and Michael Petrides
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8723–8727. Published online 2000 July 4.
PMCID: PMC27015
Dissociation of response conflict, attentional selection, and expectancy with functional magnetic resonance imaging
B. J. Casey, Kathleen M. Thomas, Tomihisa F. Welsh, Rajendra D. Badgaiyan, Clayton H. Eccard, J. Richard Jennings, and Eveline A. Crone
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8728–8733.
PMCID: PMC27016
Increased discrimination of “false memories” in autism spectrum disorder
David Q. Beversdorf, Brian W. Smith, Gregory P. Crucian, Jeffrey M. Anderson, Jocelyn M. Keillor, Anna M. Barrett, John D. Hughes, Gretchen J. Felopulos, Margaret L. Bauman, Stephen E. Nadeau, and Kenneth M. Heilman
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8734–8737.
PMCID: PMC27017
Brain-wave representation of words by superposition of a few sine waves
Patrick Suppes and Bing Han
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8738–8743. Published online 2000 July 11.
PMCID: PMC27018
Social Sciences
Psychology
Brain-wave representation of words by superposition of a few sine waves
Patrick Suppes and Bing Han
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8738–8743. Published online 2000 July 11.
PMCID: PMC27018
Corrections
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8744. Published online 2000 July 4.
PMCID: PMC56031
Corrects: Susan Brown, et al. Special Feature: Implications of the Tribolium Deformed mutant phenotype for the evolution of Hox gene function. Proc Natl Acad Sci U S A. 2000 April 25; 97(9): 4510–4514.
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8744.
PMCID: PMC56032
Corrects: Yoshihiro Kashiwaya, et al. d-β-Hydroxybutyrate protects neurons in models of Alzheimer's and Parkinson's disease. Proc Natl Acad Sci U S A. 2000 May 9; 97(10): 5440–5444.
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8745. Published online 2000 July 4.
PMCID: PMC56033
Corrects: Kamal E. Habib, et al. Oral administration of a corticotropin-releasing hormone receptor antagonist significantly attenuates behavioral, neuroendocrine, and autonomic responses to stress in primates. Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6079–6084.
Proc Natl Acad Sci U S A. 2000 July 18; 97(15): 8745.
PMCID: PMC56034
Corrects: Mary B. Callanan, et al. The IgG Fc receptor, FcγRIIB, is a target for deregulation by chromosomal translocation in malignant lymphoma. Proc Natl Acad Sci U S A. 2000 January 4; 97(1): 309–314.
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