| | This journal provides immediate access to some articles. Colloquium Papers Pathogens and hosts: The dance is the same, the couples are
different Noel Keen, Brian Staskawicz, John Mekalanos, Frederick Ausubel, and R. James Cook Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8752–8753. PMCID: PMC34007 Striking a balance: Modulation of the actin cytoskeleton
by Salmonella Jorge E. Galán and Daoguo Zhou Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8754–8761. PMCID: PMC34008 Structure and function of pectic enzymes: Virulence factors of
plant pathogens Steven R. Herron, Jacques A. E. Benen, Robert D. Scavetta, Jaap Visser, and Frances Jurnak Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8762–8769. PMCID: PMC34009 Pseudomonas syringae Hrp type III secretion system
and effector proteins Alan Collmer, Jorge L. Badel, Amy O. Charkowski, Wen-Ling Deng, Derrick E. Fouts, Adela R. Ramos, Amos H. Rehm, Deborah M. Anderson, Olaf Schneewind, Karin van Dijk, and James R. Alfano Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8770–8777. PMCID: PMC34010 Molecular and cell biology aspects of plague Guy R. Cornelis Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8778–8783. PMCID: PMC34011 A framework for interpreting the leucine-rich repeats of the
Listeria internalins Michael Marino, Laurence Braun, Pascale Cossart, and Partho Ghosh Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8784–8788. PMCID: PMC34012 Acyl-homoserine lactone quorum sensing in Gram-negative bacteria:
A signaling mechanism involved in associations with
higher organisms Matthew R. Parsek and E. Peter Greenberg Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8789–8793. PMCID: PMC34013 Phenotypic variation and intracellular parasitism by
Histoplasma capsulatum Silke Kügler, Tricia Schurtz Sebghati, Linda Groppe Eissenberg, and William E. Goldman Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8794–8798. PMCID: PMC34014 Exploitation of host cells by enteropathogenic
Escherichia coli B. A. Vallance and B. B. Finlay Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8799–8806. PMCID: PMC34015 Genetic complexity of pathogen perception by plants: The example
of Rcr3, a tomato gene required specifically
by Cf-2 Mark S. Dixon, Catherine Golstein, Colwyn M. Thomas, Erik A. van der Biezen, and Jonathan D. G. Jones Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8807–8814. PMCID: PMC34016 Plants and animals share functionally common bacterial
virulence factors Laurence G. Rahme, Frederick M. Ausubel, Hui Cao, Eliana Drenkard, Boyan C. Goumnerov, Gee W. Lau, Shalina Mahajan-Miklos, Julia Plotnikova, Man-Wah Tan, John Tsongalis, Cynthia L. Walendziewicz, and Ronald G. Tompkins Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8815–8821. PMCID: PMC34017 Role of the cystic fibrosis transmembrane conductance regulator
in innate immunity to Pseudomonas
aeruginosa infections Gerald B. Pier Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8822–8828. PMCID: PMC34018 Bad bugs and beleaguered bladders: Interplay between
uropathogenic Escherichia coli and innate
host defenses Matthew A. Mulvey, Joel D. Schilling, Juan J. Martinez, and Scott J. Hultgren Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8829–8835. PMCID: PMC34019 AvrPto-dependent Pto-interacting proteins and AvrPto-interacting
proteins in tomato Adam J. Bogdanove and Gregory B. Martin Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8836–8840. PMCID: PMC34020 Reactive oxygen and nitrogen intermediates in the relationship
between mammalian hosts and microbial pathogens Carl Nathan and Michael U. Shiloh Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8841–8848. PMCID: PMC34021 Nitric oxide and salicylic acid signaling in plant defense Daniel F. Klessig, Jörg Durner, Robert Noad, Duroy A. Navarre, David Wendehenne, Dhirendra Kumar, Jun Ma Zhou, Jyoti Shah, Shuqun Zhang, Pradeep Kachroo, Youssef Trifa, Dominique Pontier, Eric Lam, and Herman Silva Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8849–8855. PMCID: PMC34022 The role of antimicrobial peptides in animal defenses Robert E. W. Hancock and Monisha G. Scott Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8856–8861. PMCID: PMC34023 Suramin inhibits initiation of defense signaling by systemin,
chitosan, and a β-glucan elicitor in suspension-cultured
Lycopersicon peruvianum cells Johannes Stratmann, Justin Scheer, and Clarence A. Ryan Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8862–8867. PMCID: PMC34024 Commentaries Shattering the diffraction limit of light: A revolution in
fluorescence microscopy? Shimon Weiss Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8747–8749. PMCID: PMC34005 B cells in autoimmunity N. A. Mitchison and L. R. Wedderburn Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8750–8751. PMCID: PMC34006 Physical Sciences Chemistry Speeding molecular recognition by using the folding funnel: The fly-casting mechanism Benjamin A. Shoemaker, John J. Portman, and Peter G. Wolynes Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8868–8873. Published online 2000 July 25. PMCID: PMC16787 Toward elimination of discrepancies between theory and experiment: The rate constant of the atmospheric conversion of SO3 to H2SO4 Thomas Loerting and Klaus R. Liedl Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8874–8878. PMCID: PMC16788 Information theory, atoms in molecules, and molecular similarity Roman F. Nalewajski and Robert G. Parr Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8879–8882. PMCID: PMC16789 Engineering INAUGURAL ARTICLE by a Recently Elected Academy Member: Positron emission tomography provides molecular imaging of biological processes Michael E. Phelps Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9226–9233. PMCID: PMC16850 Biological Sciences Biochemistry The N terminus of microsomal Δ9 stearoyl-CoA desaturase contains the sequence determinant for its rapid degradation Hassan Mziaut, George Korza, and Juris Ozols Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8883–8888. PMCID: PMC16790 A new role for a SNARE protein as a regulator of the Ypt7/Rab-dependent stage of docking Christian Ungermann, Albert Price, and William Wickner Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8889–8891. Published online 2000 July 25. PMCID: PMC16791 Protein binding and unfolding by the chaperone ClpA and degradation by the protease ClpAP Joel R. Hoskins, Satyendra K. Singh, Michael R. Maurizi, and Sue Wickner Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8892–8897. PMCID: PMC16792 Unfolding and internalization of proteins by the ATP-dependent proteases ClpXP and ClpAP Satyendra K. Singh, Regis Grimaud, Joel R. Hoskins, Sue Wickner, and Michael R. Maurizi Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8898–8903. PMCID: PMC16793 Mouse Sebox homeobox gene expression in skin, brain, oocytes, and two-cell embryos Mario Cinquanta, Alessandra C. Rovescalli, Christine A. Kozak, and Marshall Nirenberg Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8904–8909. PMCID: PMC16794 INAUGURAL ARTICLE by a Recently Elected Academy Member: Myotubularin, a protein tyrosine phosphatase mutated in myotubular myopathy, dephosphorylates the lipid second messenger, phosphatidylinositol 3-phosphate Gregory S. Taylor, Tomohiko Maehama, and Jack E. Dixon Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8910–8915. Published online 2000 July 18. PMCID: PMC16795 Hydrolytic editing by a class II aminoacyl-tRNA synthetase Penny J. Beuning and Karin Musier-Forsyth Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8916–8920. PMCID: PMC16796 The molecular basis of vancomycin resistance in clinically relevant Enterococci: Crystal structure of d-alanyl-d-lactate ligase (VanA) David I. Roper, Trevor Huyton, Alexei Vagin, and Guy Dodson Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8921–8925. Published online 2000 July 25. PMCID: PMC16797 Bacterial-type DNA Holliday junction resolvases in eukaryotic viruses Alonzo D. Garcia, L. Aravind, Eugene V. Koonin, and Bernard Moss Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8926–8931. Published online 2000 July 11. PMCID: PMC16798 Crystal structure of Escherichia coli CyaY protein reveals a previously unidentified fold for the evolutionarily conserved frataxin family Seung-Je Cho, Myong Gyong Lee, Jin Kuk Yang, Jae Young Lee, Hyun Kyu Song, and Se Won Suh Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8932–8937. Published online 2000 July 25. PMCID: PMC16799 The central cytoplasmic loop of the major facilitator superfamily of transport proteins governs efficient membrane insertion Adam B. Weinglass and H. Ronald Kaback Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8938–8943. Published online 2000 July 4. PMCID: PMC16800 Trans catalysis in Tn5 transposition Todd A. Naumann and William S. Reznikoff Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8944–8949. Published online 2000 July 25. PMCID: PMC16801 Rapid mapping of protein functional epitopes by combinatorial alanine scanning Gregory A. Weiss, Colin K. Watanabe, Alan Zhong, Audrey Goddard, and Sachdev S. Sidhu Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8950–8954. Published online 2000 July 25. PMCID: PMC16802 Ribozyme-mediated inhibition of HIV 1 suggests nucleolar trafficking of HIV-1 RNA Alessandro Michienzi, Laurence Cagnon, Ingrid Bahner, and John J. Rossi Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8955–8960. PMCID: PMC16803 Thermodynamic characterization of the interaction between TRAF2 and tumor necrosis factor receptor peptides by isothermal titration calorimetry Hong Ye and Hao Wu Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8961–8966. Published online 2000 July 25. PMCID: PMC16804 The spliceosomal snRNP core complex of Trypanosoma brucei: Cloning and functional analysis reveals seven Sm protein constituents Zsofia Palfi, Stephan Lücke, Hans-Werner Lahm, William S. Lane, Volker Kruft, Elisabeth Bragado-Nilsson, Bertrand Séraphin, and Albrecht Bindereif Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8967–8972. Published online 2000 July 18. PMCID: PMC16805 The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex Michael Gmachl, Christian Gieffers, Alexandre V. Podtelejnikov, Matthias Mann, and Jan-Michael Peters Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8973–8978. PMCID: PMC16806 A systematic exploration of the influence of the protein stability on amyloid fibril formation in vitro Marina Ramírez-Alvarado, Jane S. Merkel, and Lynne Regan Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8979–8984. Published online 2000 July 25. PMCID: PMC16807 Hormone binding induces rapid proteasome-mediated degradation of thyroid hormone receptors Alexandra Dace, Li Zhao, Kyung Soo Park, T. Furuno, N. Takamura, M. Nakanishi, Brian L. West, John A. Hanover, and Sheue-yann Cheng Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8985–8990. Published online 2000 July 25. PMCID: PMC16808 A dual role for the kinase-like domain of the tyrosine kinase Tyk2 in interferon-α signaling Tammie C. Yeh, Elisabetta Dondi, Gilles Uzé, and Sandra Pellegrini Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8991–8996. Published online 2000 July 25. PMCID: PMC16809 Barrier-to-autointegration factor (BAF) bridges DNA in a discrete, higher-order nucleoprotein complex Ronglan Zheng, Rodolfo Ghirlando, Myung Soo Lee, Kiyoshi Mizuuchi, Michael Krause, and Robert Craigie Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8997–9002. Published online 2000 July 25. PMCID: PMC16810 High-frequency intrachromosomal gene conversion induced by triplex-forming oligonucleotides microinjected into mouse cells Zhongjun Luo, Margaret A. Macris, A. Fawad Faruqi, and Peter M. Glazer Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9003–9008. Published online 2000 July 18. PMCID: PMC16811 The cysteine desulfurase, IscS, has a major role in in vivo Fe-S cluster formation in Escherichia coli Christopher J. Schwartz, Ouliana Djaman, James A. Imlay, and Patricia J. Kiley Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9009–9014. Published online 2000 July 25. PMCID: PMC16812 Protein-interaction modules that organize nuclear function: FF domains of CA150 bind the phosphoCTD of RNA polymerase II Sherry M. Carty, Aaron C. Goldstrohm, Carles Suñé, Mariano A. Garcia-Blanco, and Arno L. Greenleaf Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9015–9020. Published online 2000 July 25. PMCID: PMC16813 Biophysics Speeding molecular recognition by using the folding funnel: The fly-casting mechanism Benjamin A. Shoemaker, John J. Portman, and Peter G. Wolynes Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8868–8873. Published online 2000 July 25. PMCID: PMC16787 Accurate and rapid docking of protein–protein complexes on the basis of intermolecular nuclear Overhauser enhancement data and dipolar couplings by rigid body minimization G. Marius Clore Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9021–9025. PMCID: PMC16814 Energetics of the HIV gp120-CD4 binding reaction David G. Myszka, Raymond W. Sweet, Preston Hensley, Michael Brigham-Burke, Peter D. Kwong, Wayne A. Hendrickson, Richard Wyatt, Joseph Sodroski, and Michael L. Doyle Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9026–9031. PMCID: PMC16815 Modulation of CTP:phosphocholine cytidylyltransferase by membrane curvature elastic stress George S. Attard, Richard H. Templer, Wendy S. Smith, Alan N. Hunt, and Suzanne Jackowski Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9032–9036. Published online 2000 July 25. PMCID: PMC16816 Kinetic and thermodynamic control of protein adsorption J. Satulovsky, M. A. Carignano, and I. Szleifer Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9037–9041. Published online 2000 July 25. PMCID: PMC16817 Cell Biology Down-regulation of p21WAF1/CIP1 or p27Kip1 abrogates antiestrogen-mediated cell cycle arrest in human breast cancer cells Sandrine Cariou, Jeffrey C. H. Donovan, W. M. Flanagan, Andrea Milic, Nandita Bhattacharya, and Joyce M. Slingerland Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9042–9046. Published online 2000 July 25. PMCID: PMC16818 Recognition of the 300-kDa mannose 6-phosphate receptor cytoplasmic domain by 47-kDa tail-interacting protein Joke G. Orsel, Paul M. Sincock, Jeffrey P. Krise, and Suzanne R. Pfeffer Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9047–9051. Published online 2000 July 25. PMCID: PMC16819 The NF-κB signal transduction pathway in aortic endothelial cells is primed for activation in regions predisposed to atherosclerotic lesion formation Leena Hajra, Andrew I. Evans, Mian Chen, Sharon J. Hyduk, Tucker Collins, and Myron I. Cybulsky Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9052–9057. PMCID: PMC16820 Molecular basis of protein kinase C-induced activation of ATP-sensitive potassium channels Peter E. Light, Christopher Bladen, Robert J. Winkfein, Michael P. Walsh, and Robert J. French Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9058–9063. Published online 2000 July 25. PMCID: PMC16821 The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin Benjamin Boettner, Eve-Ellen Govek, Justin Cross, and Linda Van Aelst Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9064–9069. PMCID: PMC16822 Neisseria meningitidis porin PorB interacts with mitochondria and protects cells from apoptosis Paola Massari, Yu Ho, and Lee M. Wetzler Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9070–9075. PMCID: PMC16823 Paxillin α and Crk-associated substrate exert opposing effects on cell migration and contact inhibition of growth through tyrosine phosphorylation Hajime Yano, Hiroshi Uchida, Teruo Iwasaki, Mutsuko Mukai, Hitoshi Akedo, Kuniaki Nakamura, Shigeru Hashimoto, and Hisataka Sabe Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9076–9081. PMCID: PMC16824 Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia Richard K. Bruick Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9082–9087. PMCID: PMC16825 Transcription-coupled repair in yeast is independent from ubiquitylation of RNA pol II: Implications for Cockayne's syndrome Lori Lommel, Miriam E. Bucheli, and Kevin S. Sweder Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9088–9092. Published online 2000 July 18. PMCID: PMC16826 Developmental Biology Gastrulation Defective is a serine protease involved in activating the receptor Toll to polarize the Drosophila embryo Jin-Hua Han, Si Hyoung Lee, Yue-Qing Tan, Ellen K. LeMosy, and Carl Hashimoto Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9093–9097. PMCID: PMC16827 Spatial control of cell differentiation in Myxococcus xanthus Bryan Julien, A. Dale Kaiser, and Anthony Garza Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9098–9103. PMCID: PMC16828 Placental expression of the nonclassical MHC class I molecule Mamu-AG at implantation in the rhesus monkey I. I. Slukvin, D. P. Lunn, D. I. Watkins, and T. G. Golos Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9104–9109. PMCID: PMC16829 Evolution From the Cover: Artificial ecosystem selection William Swenson, David Sloan Wilson, and Roberta Elias Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9110–9114. Published online 2000 July 11. PMCID: PMC16830 Evolutionary consequences of changes in species' geographical distributions driven by Milankovitch climate oscillations Mats Dynesius and Roland Jansson Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9115–9120. PMCID: PMC16831 Comparing sequenced segments of the tomato and Arabidopsis genomes: Large-scale duplication followed by selective gene loss creates a network of synteny Hsin-Mei Ku, Todd Vision, Jiping Liu, and Steven D. Tanksley Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9121–9126. Published online 2000 July 25. PMCID: PMC16832 Genetics Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray Tetsuya S. Tanaka, Saied A. Jaradat, Meng K. Lim, George J. Kargul, Xiaohong Wang, Marija J. Grahovac, Serafino Pantano, Yuri Sano, Yulan Piao, Ramaiah Nagaraja, Hirofumi Doi, William H. Wood, III, Kevin G. Becker, and Minoru S. H. Ko Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9127–9132. PMCID: PMC16833 3′ poly(A) is dispensable for translation Anjanette M. Searfoss and Reed B. Wickner Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9133–9137. PMCID: PMC16834 Prediction, identification, and artificial selection of DNA rearrangements in Rhizobium: Toward a natural genomic design Margarita Flores, Patrick Mavingui, Xavier Perret, William J. Broughton, David Romero, Georgina Hernández, Guillermo Dávila, and Rafael Palacios Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9138–9143. PMCID: PMC16835 Engineering blood meal-activated systemic immunity in the yellow fever mosquito, Aedes aegypti Vladimir Kokoza, Abduelaziz Ahmed, Wen-Long Cho, Nijole Jasinskiene, Anthony A. James, and Alexander Raikhel Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9144–9149. Published online 2000 July 25. PMCID: PMC16836 A chromatin insulator protects retrovirus vectors from chromosomal position effects David W. Emery, Evangelia Yannaki, Julie Tubb, and George Stamatoyannopoulos Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9150–9155. Published online 2000 July 25. PMCID: PMC16837 Immunology B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1 Hong-Bing Shu and Holly Johnson Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9156–9161. Published online 2000 July 25. PMCID: PMC16838 Selective inhibition of HIV replication in primary macrophages but not T lymphocytes by macrophage-derived chemokine Manuela Cota, Manuela Mengozzi, Elisa Vicenzi, Paola Panina-Bordignon, Francesco Sinigaglia, Pietro Transidico, Silvano Sozzani, Alberto Mantovani, and Guido Poli Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9162–9167. Published online 2000 July 25. PMCID: PMC16839 Medical Sciences The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q Arndt Borkhardt, Stig Bojesen, Oskar A. Haas, Uta Fuchs, Dominique Bartelheimer, Ivan F. Loncarevic, Rainer M. Bohle, Jochen Harbott, Reinald Repp, Ulrich Jaeger, Susanne Viehmann, Traudl Henn, Petra Korth, Dirk Scharr, and Fritz Lampert Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9168–9173. Published online 2000 July 25. PMCID: PMC16840 The development of fatal myocarditis and polymyositis in mice heterozygous for IFN-γ and lacking the SOCS-1 gene Donald Metcalf, Ladina Di Rago, Sandra Mifsud, Lynne Hartley, and Warren S. Alexander Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9174–9179. Published online 2000 July 25. PMCID: PMC16841 Inhibition of growth and metastatic progression of pancreatic carcinoma in hamster after somatostatin receptor subtype 2 (sst2) gene expression and administration of cytotoxic somatostatin analog AN-238 Naoual Benali, Pierre Cordelier, Denis Calise, Philippe Pagès, Philippe Rochaix, Attila Nagy, Jean-Pierre Estève, Parviz M. Pour, Andrew V. Schally, Nicole Vaysse, Christiane Susini, and Louis Buscail Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9180–9185. Published online 2000 July 18. PMCID: PMC16842 In vivo immunological function of mast cells derived from embryonic stem cells: An approach for the rapid analysis of even embryonic lethal mutations in adult mice in vivo Mindy Tsai, Jochen Wedemeyer, Soula Ganiatsas, See-Ying Tam, Leonard I. Zon, and Stephen J. Galli Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9186–9190. Published online 2000 July 25. PMCID: PMC16843 In vivo formation of complex microvessels lined by human endothelial cells in an immunodeficient mouse Jeffrey S. Schechner, Anjali K. Nath, Lian Zheng, Martin S. Kluger, Christopher C. W. Hughes, M. Rocio Sierra-Honigmann, Marc I. Lorber, George Tellides, Michael Kashgarian, Alfred L. M. Bothwell, and Jordan S. Pober Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9191–9196. Published online 2000 July 11. PMCID: PMC16844 In vitro and in vivo evidence for orphan nuclear receptor RORα function in bone metabolism Thomas Meyer, Michaela Kneissel, Jean Mariani, and Brigitte Fournier Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9197–9202. Published online 2000 July 18. PMCID: PMC16845 T cell homeostasis in patients with rheumatoid arthritis Kerstin Koetz, Ewa Bryl, Kay Spickschen, W. Michael O'Fallon, Jörg J. Goronzy, and Cornelia M. Weyand Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9203–9208. PMCID: PMC16846 From the Cover: Conditional up-regulation of MHC class I in skeletal muscle leads to self-sustaining autoimmune myositis and myositis-specific autoantibodies Kanneboyina Nagaraju, Nina Raben, Lisa Loeffler, Tomasina Parker, Paul J. Rochon, Eunice Lee, Carol Danning, Ryuichi Wada, Cynthia Thompson, Gul Bahtiyar, Joseph Craft, Rob Hooft van Huijsduijnen, and Paul Plotz Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9209–9214. PMCID: PMC16847 Inactivation of wild-type p53 tumor suppressor by electrophilic prostaglandins P. J. Moos, K. Edes, and F. A. Fitzpatrick Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9215–9220. Published online 2000 July 25. PMCID: PMC16848 Intratumoral injection of adenoviral vectors encoding tumor-targeted immunoconjugates for cancer immunotherapy Zhiwei Hu and Alan Garen Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9221–9225. PMCID: PMC16849 INAUGURAL ARTICLE by a Recently Elected Academy Member: Positron emission tomography provides molecular imaging of biological processes Michael E. Phelps Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9226–9233. PMCID: PMC16850 Cloning and expression of a novel human antibody–antigen pair associated with Felty's syndrome Henrik J. Ditzel, Yasufumi Masaki, Heidi Nielsen, Lauge Farnaes, and Dennis R. Burton Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9234–9239. PMCID: PMC16851 Microbiology Snapshots of usher-mediated protein secretion and ordered pilus assembly Evan T. Saulino, Esther Bullitt, and Scott J. Hultgren Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9240–9245. Published online 2000 July 25. PMCID: PMC16852 The pleiotropic response regulator DegU functions as a priming protein in competence development in Bacillus subtilis Leendert W. Hamoen, Aske F. Van Werkhoven, Gerard Venema, and David Dubnau Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9246–9251. Published online 2000 July 25. PMCID: PMC16853 Coreceptor restriction within the HLA-DQ locus for Epstein–Barr virus infection Keith M. Haan and Richard Longnecker Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9252–9257. Published online 2000 July 25. PMCID: PMC16854 Lipophosphoglycan is a virulence factor distinct from related glycoconjugates in the protozoan parasite Leishmania major Gerald F. Späth, Linda Epstein, Ben Leader, Steven M. Singer, Herbert A. Avila, Salvatore J. Turco, and Stephen M. Beverley Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9258–9263. Published online 2000 July 25. PMCID: PMC16855 Neurobiology Pseudorabies virus expressing enhanced green fluorescent protein: A tool for in vitro electrophysiological analysis of transsynaptically labeled neurons in identified central nervous system circuits Bret N. Smith, Bruce W. Banfield, Cynthia A. Smeraski, Christine L. Wilcox, F. Edward Dudek, Lynn W. Enquist, and Gary E. Pickard Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9264–9269. PMCID: PMC16856 Neuroprotective potential of a viral vector system induced by a neurological insult Clare R. Ozawa, Jill J. Ho, David J. Tsai, Dora Y. Ho, and Robert M. Sapolsky Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9270–9275. Published online 2000 July 25. PMCID: PMC16857 Subnucleus-specific loss of neurons in medial thalamus of schizophrenics Gregory J. Popken, William E. Bunney, Jr., Steven G. Potkin, and Edward G. Jones Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9276–9280. Published online 2000 July 25. PMCID: PMC16858 Learning about pain: The neural substrate of the prediction error for aversive events Alexander Ploghaus, Irene Tracey, Stuart Clare, Joseph S. Gati, J. Nicholas P. Rawlins, and Paul M. Matthews Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9281–9286. Published online 2000 July 25. PMCID: PMC16859 Spinophilin regulates the formation and function of dendritic spines Jian Feng, Zhen Yan, Adriana Ferreira, Kazuhito Tomizawa, Jason A. Liauw, Min Zhuo, Patrick B. Allen, Charles C. Ouimet, and Paul Greengard Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9287–9292. PMCID: PMC16860 The role of dynamic palmitoylation in Ca2+ channel inactivation Joyce H. Hurley, Anne L. Cahill, Kevin P. M. Currie, and Aaron P. Fox Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9293–9298. Published online 2000 July 18. PMCID: PMC16861 Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid β-protein generation Weiming Xia, William J. Ray, Beth L. Ostaszewski, Talat Rahmati, W. Taylor Kimberly, Michael S. Wolfe, Jimin Zhang, Alison M. Goate, and Dennis J. Selkoe Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9299–9304. PMCID: PMC16862 Pharmacology Specific binding sites for alcohols and anesthetics on ligand-gated ion channels Maria Paola Mascia, James R. Trudell, and R. Adron Harris Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9305–9310. Published online 2000 July 25. PMCID: PMC16863 Role of C-terminal domains of the G protein β subunit in the activation of effectors Chang-Seon Myung and James C. Garrison Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9311–9316. PMCID: PMC16864 Physiology Interleukin-6 is an essential, corticotropin-releasing hormone-independent stimulator of the adrenal axis during immune system activation Kathleen E. Bethin, Sherri K. Vogt, and Louis J. Muglia Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9317–9322. PMCID: PMC16865 Plant Biology The Arabidopsis dnd1 “defense, no death” gene encodes a mutated cyclic nucleotide-gated ion channel Steven J. Clough, Kevin A. Fengler, I-ching Yu, Bernadette Lippok, Roger K. Smith, Jr., and Andrew F. Bent Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9323–9328. Published online 2000 July 18. PMCID: PMC16866 New roles for cis-jasmone as an insect semiochemical and in plant defense Michael A. Birkett, Colin A. M. Campbell, Keith Chamberlain, Emilio Guerrieri, Alastair J. Hick, Janet L. Martin, Michaela Matthes, Johnathan A. Napier, Jan Pettersson, John A. Pickett, Guy M. Poppy, Eleanor M. Pow, Barry J. Pye, Lesley E. Smart, George H. Wadhams, Lester J. Wadhams, and Christine M. Woodcock Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9329–9334. Published online 2000 July 18. PMCID: PMC16867 Population Biology Etiology of interepidemic periods of mosquito-borne disease Simon I. Hay, Monica F. Myers, Donald S. Burke, David W. Vaughn, Timothy Endy, Nisalak Ananda, G. Dennis Shanks, Robert W. Snow, and David J. Rogers Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9335–9339. PMCID: PMC16868 Social Sciences Social Sciences INAUGURAL ARTICLE by a Recently Elected Academy Member: A dynamic model of social network formation Brian Skyrms and Robin Pemantle Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9340–9346. PMCID: PMC16869 Corrections Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9347. PMCID: PMC56048 Corrects: Shigeomi Shimizu, et al. BH4 domain of antiapoptotic Bcl-2 family members closes
voltage-dependent anion channel and inhibits apoptotic
mitochondrial changes and cell death. Proc Natl Acad Sci U S A. 2000 March 28; 97(7): 3100–3105. Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9347. Published online 2000 July 18. PMCID: PMC56049 Corrects: Norio Ishida, et al. Biological clocks. Proc Natl Acad Sci U S A. 1999 August 3; 96(16): 8819–8820. |