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Volume 97(16);  August 1, 2000
Colloquium Papers
Pathogens and hosts: The dance is the same, the couples are different
Noel Keen, Brian Staskawicz, John Mekalanos, Frederick Ausubel, and R. James Cook
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8752–8753.
PMCID: PMC34007
Striking a balance: Modulation of the actin cytoskeleton by Salmonella
Jorge E. Galán and Daoguo Zhou
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8754–8761.
PMCID: PMC34008
Structure and function of pectic enzymes: Virulence factors of plant pathogens
Steven R. Herron, Jacques A. E. Benen, Robert D. Scavetta, Jaap Visser, and Frances Jurnak
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8762–8769.
PMCID: PMC34009
Pseudomonas syringae Hrp type III secretion system and effector proteins
Alan Collmer, Jorge L. Badel, Amy O. Charkowski, Wen-Ling Deng, Derrick E. Fouts, Adela R. Ramos, Amos H. Rehm, Deborah M. Anderson, Olaf Schneewind, Karin van Dijk, and James R. Alfano
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8770–8777.
PMCID: PMC34010
Molecular and cell biology aspects of plague
Guy R. Cornelis
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8778–8783.
PMCID: PMC34011
A framework for interpreting the leucine-rich repeats of the Listeria internalins
Michael Marino, Laurence Braun, Pascale Cossart, and Partho Ghosh
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8784–8788.
PMCID: PMC34012
Acyl-homoserine lactone quorum sensing in Gram-negative bacteria: A signaling mechanism involved in associations with higher organisms
Matthew R. Parsek and E. Peter Greenberg
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8789–8793.
PMCID: PMC34013
Phenotypic variation and intracellular parasitism by Histoplasma capsulatum
Silke Kügler, Tricia Schurtz Sebghati, Linda Groppe Eissenberg, and William E. Goldman
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8794–8798.
PMCID: PMC34014
Exploitation of host cells by enteropathogenic Escherichia coli
B. A. Vallance and B. B. Finlay
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8799–8806.
PMCID: PMC34015
Genetic complexity of pathogen perception by plants: The example of Rcr3, a tomato gene required specifically by Cf-2
Mark S. Dixon, Catherine Golstein, Colwyn M. Thomas, Erik A. van der Biezen, and Jonathan D. G. Jones
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8807–8814.
PMCID: PMC34016
Plants and animals share functionally common bacterial virulence factors
Laurence G. Rahme, Frederick M. Ausubel, Hui Cao, Eliana Drenkard, Boyan C. Goumnerov, Gee W. Lau, Shalina Mahajan-Miklos, Julia Plotnikova, Man-Wah Tan, John Tsongalis, Cynthia L. Walendziewicz, and Ronald G. Tompkins
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8815–8821.
PMCID: PMC34017
Role of the cystic fibrosis transmembrane conductance regulator in innate immunity to Pseudomonas aeruginosa infections
Gerald B. Pier
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8822–8828.
PMCID: PMC34018
Bad bugs and beleaguered bladders: Interplay between uropathogenic Escherichia coli and innate host defenses
Matthew A. Mulvey, Joel D. Schilling, Juan J. Martinez, and Scott J. Hultgren
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8829–8835.
PMCID: PMC34019
AvrPto-dependent Pto-interacting proteins and AvrPto-interacting proteins in tomato
Adam J. Bogdanove and Gregory B. Martin
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8836–8840.
PMCID: PMC34020
Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens
Carl Nathan and Michael U. Shiloh
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8841–8848.
PMCID: PMC34021
Nitric oxide and salicylic acid signaling in plant defense
Daniel F. Klessig, Jörg Durner, Robert Noad, Duroy A. Navarre, David Wendehenne, Dhirendra Kumar, Jun Ma Zhou, Jyoti Shah, Shuqun Zhang, Pradeep Kachroo, Youssef Trifa, Dominique Pontier, Eric Lam, and Herman Silva
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8849–8855.
PMCID: PMC34022
The role of antimicrobial peptides in animal defenses
Robert E. W. Hancock and Monisha G. Scott
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8856–8861.
PMCID: PMC34023
Suramin inhibits initiation of defense signaling by systemin, chitosan, and a β-glucan elicitor in suspension-cultured Lycopersicon peruvianum cells
Johannes Stratmann, Justin Scheer, and Clarence A. Ryan
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8862–8867.
PMCID: PMC34024
Commentaries
Shattering the diffraction limit of light: A revolution in fluorescence microscopy?
Shimon Weiss
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8747–8749.
PMCID: PMC34005
B cells in autoimmunity
N. A. Mitchison and L. R. Wedderburn
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8750–8751.
PMCID: PMC34006
Physical Sciences
Chemistry
Speeding molecular recognition by using the folding funnel: The fly-casting mechanism
Benjamin A. Shoemaker, John J. Portman, and Peter G. Wolynes
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8868–8873. Published online 2000 July 25.
PMCID: PMC16787
Toward elimination of discrepancies between theory and experiment: The rate constant of the atmospheric conversion of SO3 to H2SO4
Thomas Loerting and Klaus R. Liedl
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8874–8878.
PMCID: PMC16788
Information theory, atoms in molecules, and molecular similarity
Roman F. Nalewajski and Robert G. Parr
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8879–8882.
PMCID: PMC16789
Engineering
Positron emission tomography provides molecular imaging of biological processes
Michael E. Phelps
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9226–9233.
PMCID: PMC16850
Biological Sciences
Biochemistry
The N terminus of microsomal Δ9 stearoyl-CoA desaturase contains the sequence determinant for its rapid degradation
Hassan Mziaut, George Korza, and Juris Ozols
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8883–8888.
PMCID: PMC16790
A new role for a SNARE protein as a regulator of the Ypt7/Rab-dependent stage of docking
Christian Ungermann, Albert Price, and William Wickner
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8889–8891. Published online 2000 July 25.
PMCID: PMC16791
Protein binding and unfolding by the chaperone ClpA and degradation by the protease ClpAP
Joel R. Hoskins, Satyendra K. Singh, Michael R. Maurizi, and Sue Wickner
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8892–8897.
PMCID: PMC16792
Unfolding and internalization of proteins by the ATP-dependent proteases ClpXP and ClpAP
Satyendra K. Singh, Regis Grimaud, Joel R. Hoskins, Sue Wickner, and Michael R. Maurizi
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8898–8903.
PMCID: PMC16793
Mouse Sebox homeobox gene expression in skin, brain, oocytes, and two-cell embryos
Mario Cinquanta, Alessandra C. Rovescalli, Christine A. Kozak, and Marshall Nirenberg
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8904–8909.
PMCID: PMC16794
Myotubularin, a protein tyrosine phosphatase mutated in myotubular myopathy, dephosphorylates the lipid second messenger, phosphatidylinositol 3-phosphate
Gregory S. Taylor, Tomohiko Maehama, and Jack E. Dixon
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8910–8915. Published online 2000 July 18.
PMCID: PMC16795
Hydrolytic editing by a class II aminoacyl-tRNA synthetase
Penny J. Beuning and Karin Musier-Forsyth
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8916–8920.
PMCID: PMC16796
The molecular basis of vancomycin resistance in clinically relevant Enterococci: Crystal structure of d-alanyl-d-lactate ligase (VanA)
David I. Roper, Trevor Huyton, Alexei Vagin, and Guy Dodson
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8921–8925. Published online 2000 July 25.
PMCID: PMC16797
Bacterial-type DNA Holliday junction resolvases in eukaryotic viruses
Alonzo D. Garcia, L. Aravind, Eugene V. Koonin, and Bernard Moss
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8926–8931. Published online 2000 July 11.
PMCID: PMC16798
Crystal structure of Escherichia coli CyaY protein reveals a previously unidentified fold for the evolutionarily conserved frataxin family
Seung-Je Cho, Myong Gyong Lee, Jin Kuk Yang, Jae Young Lee, Hyun Kyu Song, and Se Won Suh
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8932–8937. Published online 2000 July 25.
PMCID: PMC16799
The central cytoplasmic loop of the major facilitator superfamily of transport proteins governs efficient membrane insertion
Adam B. Weinglass and H. Ronald Kaback
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8938–8943. Published online 2000 July 4.
PMCID: PMC16800
Trans catalysis in Tn5 transposition
Todd A. Naumann and William S. Reznikoff
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8944–8949. Published online 2000 July 25.
PMCID: PMC16801
Rapid mapping of protein functional epitopes by combinatorial alanine scanning
Gregory A. Weiss, Colin K. Watanabe, Alan Zhong, Audrey Goddard, and Sachdev S. Sidhu
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8950–8954. Published online 2000 July 25.
PMCID: PMC16802
Ribozyme-mediated inhibition of HIV 1 suggests nucleolar trafficking of HIV-1 RNA
Alessandro Michienzi, Laurence Cagnon, Ingrid Bahner, and John J. Rossi
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8955–8960.
PMCID: PMC16803
Thermodynamic characterization of the interaction between TRAF2 and tumor necrosis factor receptor peptides by isothermal titration calorimetry
Hong Ye and Hao Wu
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8961–8966. Published online 2000 July 25.
PMCID: PMC16804
The spliceosomal snRNP core complex of Trypanosoma brucei: Cloning and functional analysis reveals seven Sm protein constituents
Zsofia Palfi, Stephan Lücke, Hans-Werner Lahm, William S. Lane, Volker Kruft, Elisabeth Bragado-Nilsson, Bertrand Séraphin, and Albrecht Bindereif
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8967–8972. Published online 2000 July 18.
PMCID: PMC16805
The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex
Michael Gmachl, Christian Gieffers, Alexandre V. Podtelejnikov, Matthias Mann, and Jan-Michael Peters
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8973–8978.
PMCID: PMC16806
A systematic exploration of the influence of the protein stability on amyloid fibril formation in vitro
Marina Ramírez-Alvarado, Jane S. Merkel, and Lynne Regan
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8979–8984. Published online 2000 July 25.
PMCID: PMC16807
Hormone binding induces rapid proteasome-mediated degradation of thyroid hormone receptors
Alexandra Dace, Li Zhao, Kyung Soo Park, T. Furuno, N. Takamura, M. Nakanishi, Brian L. West, John A. Hanover, and Sheue-yann Cheng
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8985–8990. Published online 2000 July 25.
PMCID: PMC16808
A dual role for the kinase-like domain of the tyrosine kinase Tyk2 in interferon-α signaling
Tammie C. Yeh, Elisabetta Dondi, Gilles Uzé, and Sandra Pellegrini
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8991–8996. Published online 2000 July 25.
PMCID: PMC16809
Barrier-to-autointegration factor (BAF) bridges DNA in a discrete, higher-order nucleoprotein complex
Ronglan Zheng, Rodolfo Ghirlando, Myung Soo Lee, Kiyoshi Mizuuchi, Michael Krause, and Robert Craigie
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8997–9002. Published online 2000 July 25.
PMCID: PMC16810
High-frequency intrachromosomal gene conversion induced by triplex-forming oligonucleotides microinjected into mouse cells
Zhongjun Luo, Margaret A. Macris, A. Fawad Faruqi, and Peter M. Glazer
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9003–9008. Published online 2000 July 18.
PMCID: PMC16811
The cysteine desulfurase, IscS, has a major role in in vivo Fe-S cluster formation in Escherichia coli
Christopher J. Schwartz, Ouliana Djaman, James A. Imlay, and Patricia J. Kiley
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9009–9014. Published online 2000 July 25.
PMCID: PMC16812
Protein-interaction modules that organize nuclear function: FF domains of CA150 bind the phosphoCTD of RNA polymerase II
Sherry M. Carty, Aaron C. Goldstrohm, Carles Suñé, Mariano A. Garcia-Blanco, and Arno L. Greenleaf
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9015–9020. Published online 2000 July 25.
PMCID: PMC16813
Biophysics
Speeding molecular recognition by using the folding funnel: The fly-casting mechanism
Benjamin A. Shoemaker, John J. Portman, and Peter G. Wolynes
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 8868–8873. Published online 2000 July 25.
PMCID: PMC16787
Accurate and rapid docking of protein–protein complexes on the basis of intermolecular nuclear Overhauser enhancement data and dipolar couplings by rigid body minimization
G. Marius Clore
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9021–9025.
PMCID: PMC16814
Energetics of the HIV gp120-CD4 binding reaction
David G. Myszka, Raymond W. Sweet, Preston Hensley, Michael Brigham-Burke, Peter D. Kwong, Wayne A. Hendrickson, Richard Wyatt, Joseph Sodroski, and Michael L. Doyle
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9026–9031.
PMCID: PMC16815
Modulation of CTP:phosphocholine cytidylyltransferase by membrane curvature elastic stress
George S. Attard, Richard H. Templer, Wendy S. Smith, Alan N. Hunt, and Suzanne Jackowski
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9032–9036. Published online 2000 July 25.
PMCID: PMC16816
Kinetic and thermodynamic control of protein adsorption
J. Satulovsky, M. A. Carignano, and I. Szleifer
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9037–9041. Published online 2000 July 25.
PMCID: PMC16817
Cell Biology
Down-regulation of p21WAF1/CIP1 or p27Kip1 abrogates antiestrogen-mediated cell cycle arrest in human breast cancer cells
Sandrine Cariou, Jeffrey C. H. Donovan, W. M. Flanagan, Andrea Milic, Nandita Bhattacharya, and Joyce M. Slingerland
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9042–9046. Published online 2000 July 25.
PMCID: PMC16818
Recognition of the 300-kDa mannose 6-phosphate receptor cytoplasmic domain by 47-kDa tail-interacting protein
Joke G. Orsel, Paul M. Sincock, Jeffrey P. Krise, and Suzanne R. Pfeffer
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9047–9051. Published online 2000 July 25.
PMCID: PMC16819
The NF-κB signal transduction pathway in aortic endothelial cells is primed for activation in regions predisposed to atherosclerotic lesion formation
Leena Hajra, Andrew I. Evans, Mian Chen, Sharon J. Hyduk, Tucker Collins, and Myron I. Cybulsky
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9052–9057.
PMCID: PMC16820
Molecular basis of protein kinase C-induced activation of ATP-sensitive potassium channels
Peter E. Light, Christopher Bladen, Robert J. Winkfein, Michael P. Walsh, and Robert J. French
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9058–9063. Published online 2000 July 25.
PMCID: PMC16821
The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin
Benjamin Boettner, Eve-Ellen Govek, Justin Cross, and Linda Van Aelst
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9064–9069.
PMCID: PMC16822
Neisseria meningitidis porin PorB interacts with mitochondria and protects cells from apoptosis
Paola Massari, Yu Ho, and Lee M. Wetzler
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9070–9075.
PMCID: PMC16823
Paxillin α and Crk-associated substrate exert opposing effects on cell migration and contact inhibition of growth through tyrosine phosphorylation
Hajime Yano, Hiroshi Uchida, Teruo Iwasaki, Mutsuko Mukai, Hitoshi Akedo, Kuniaki Nakamura, Shigeru Hashimoto, and Hisataka Sabe
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9076–9081.
PMCID: PMC16824
Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia
Richard K. Bruick
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9082–9087.
PMCID: PMC16825
Transcription-coupled repair in yeast is independent from ubiquitylation of RNA pol II: Implications for Cockayne's syndrome
Lori Lommel, Miriam E. Bucheli, and Kevin S. Sweder
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9088–9092. Published online 2000 July 18.
PMCID: PMC16826
Developmental Biology
Gastrulation Defective is a serine protease involved in activating the receptor Toll to polarize the Drosophila embryo
Jin-Hua Han, Si Hyoung Lee, Yue-Qing Tan, Ellen K. LeMosy, and Carl Hashimoto
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9093–9097.
PMCID: PMC16827
Spatial control of cell differentiation in Myxococcus xanthus
Bryan Julien, A. Dale Kaiser, and Anthony Garza
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9098–9103.
PMCID: PMC16828
Placental expression of the nonclassical MHC class I molecule Mamu-AG at implantation in the rhesus monkey
I. I. Slukvin, D. P. Lunn, D. I. Watkins, and T. G. Golos
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9104–9109.
PMCID: PMC16829
Evolution
From the Cover:
Artificial ecosystem selection
William Swenson, David Sloan Wilson, and Roberta Elias
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9110–9114. Published online 2000 July 11.
PMCID: PMC16830
Evolutionary consequences of changes in species' geographical distributions driven by Milankovitch climate oscillations
Mats Dynesius and Roland Jansson
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9115–9120.
PMCID: PMC16831
Comparing sequenced segments of the tomato and Arabidopsis genomes: Large-scale duplication followed by selective gene loss creates a network of synteny
Hsin-Mei Ku, Todd Vision, Jiping Liu, and Steven D. Tanksley
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9121–9126. Published online 2000 July 25.
PMCID: PMC16832
Genetics
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray
Tetsuya S. Tanaka, Saied A. Jaradat, Meng K. Lim, George J. Kargul, Xiaohong Wang, Marija J. Grahovac, Serafino Pantano, Yuri Sano, Yulan Piao, Ramaiah Nagaraja, Hirofumi Doi, William H. Wood, III, Kevin G. Becker, and Minoru S. H. Ko
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9127–9132.
PMCID: PMC16833
3′ poly(A) is dispensable for translation
Anjanette M. Searfoss and Reed B. Wickner
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9133–9137.
PMCID: PMC16834
Prediction, identification, and artificial selection of DNA rearrangements in Rhizobium: Toward a natural genomic design
Margarita Flores, Patrick Mavingui, Xavier Perret, William J. Broughton, David Romero, Georgina Hernández, Guillermo Dávila, and Rafael Palacios
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9138–9143.
PMCID: PMC16835
Engineering blood meal-activated systemic immunity in the yellow fever mosquito, Aedes aegypti
Vladimir Kokoza, Abduelaziz Ahmed, Wen-Long Cho, Nijole Jasinskiene, Anthony A. James, and Alexander Raikhel
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9144–9149. Published online 2000 July 25.
PMCID: PMC16836
A chromatin insulator protects retrovirus vectors from chromosomal position effects
David W. Emery, Evangelia Yannaki, Julie Tubb, and George Stamatoyannopoulos
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9150–9155. Published online 2000 July 25.
PMCID: PMC16837
Immunology
B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1
Hong-Bing Shu and Holly Johnson
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9156–9161. Published online 2000 July 25.
PMCID: PMC16838
Selective inhibition of HIV replication in primary macrophages but not T lymphocytes by macrophage-derived chemokine
Manuela Cota, Manuela Mengozzi, Elisa Vicenzi, Paola Panina-Bordignon, Francesco Sinigaglia, Pietro Transidico, Silvano Sozzani, Alberto Mantovani, and Guido Poli
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9162–9167. Published online 2000 July 25.
PMCID: PMC16839
Medical Sciences
The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q
Arndt Borkhardt, Stig Bojesen, Oskar A. Haas, Uta Fuchs, Dominique Bartelheimer, Ivan F. Loncarevic, Rainer M. Bohle, Jochen Harbott, Reinald Repp, Ulrich Jaeger, Susanne Viehmann, Traudl Henn, Petra Korth, Dirk Scharr, and Fritz Lampert
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9168–9173. Published online 2000 July 25.
PMCID: PMC16840
The development of fatal myocarditis and polymyositis in mice heterozygous for IFN-γ and lacking the SOCS-1 gene
Donald Metcalf, Ladina Di Rago, Sandra Mifsud, Lynne Hartley, and Warren S. Alexander
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9174–9179. Published online 2000 July 25.
PMCID: PMC16841
Inhibition of growth and metastatic progression of pancreatic carcinoma in hamster after somatostatin receptor subtype 2 (sst2) gene expression and administration of cytotoxic somatostatin analog AN-238
Naoual Benali, Pierre Cordelier, Denis Calise, Philippe Pagès, Philippe Rochaix, Attila Nagy, Jean-Pierre Estève, Parviz M. Pour, Andrew V. Schally, Nicole Vaysse, Christiane Susini, and Louis Buscail
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9180–9185. Published online 2000 July 18.
PMCID: PMC16842
In vivo immunological function of mast cells derived from embryonic stem cells: An approach for the rapid analysis of even embryonic lethal mutations in adult mice in vivo
Mindy Tsai, Jochen Wedemeyer, Soula Ganiatsas, See-Ying Tam, Leonard I. Zon, and Stephen J. Galli
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9186–9190. Published online 2000 July 25.
PMCID: PMC16843
In vivo formation of complex microvessels lined by human endothelial cells in an immunodeficient mouse
Jeffrey S. Schechner, Anjali K. Nath, Lian Zheng, Martin S. Kluger, Christopher C. W. Hughes, M. Rocio Sierra-Honigmann, Marc I. Lorber, George Tellides, Michael Kashgarian, Alfred L. M. Bothwell, and Jordan S. Pober
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9191–9196. Published online 2000 July 11.
PMCID: PMC16844
In vitro and in vivo evidence for orphan nuclear receptor RORα function in bone metabolism
Thomas Meyer, Michaela Kneissel, Jean Mariani, and Brigitte Fournier
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9197–9202. Published online 2000 July 18.
PMCID: PMC16845
T cell homeostasis in patients with rheumatoid arthritis
Kerstin Koetz, Ewa Bryl, Kay Spickschen, W. Michael O'Fallon, Jörg J. Goronzy, and Cornelia M. Weyand
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9203–9208.
PMCID: PMC16846
From the Cover:
Conditional up-regulation of MHC class I in skeletal muscle leads to self-sustaining autoimmune myositis and myositis-specific autoantibodies
Kanneboyina Nagaraju, Nina Raben, Lisa Loeffler, Tomasina Parker, Paul J. Rochon, Eunice Lee, Carol Danning, Ryuichi Wada, Cynthia Thompson, Gul Bahtiyar, Joseph Craft, Rob Hooft van Huijsduijnen, and Paul Plotz
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9209–9214.
PMCID: PMC16847
Inactivation of wild-type p53 tumor suppressor by electrophilic prostaglandins
P. J. Moos, K. Edes, and F. A. Fitzpatrick
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9215–9220. Published online 2000 July 25.
PMCID: PMC16848
Intratumoral injection of adenoviral vectors encoding tumor-targeted immunoconjugates for cancer immunotherapy
Zhiwei Hu and Alan Garen
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9221–9225.
PMCID: PMC16849
Positron emission tomography provides molecular imaging of biological processes
Michael E. Phelps
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9226–9233.
PMCID: PMC16850
Cloning and expression of a novel human antibody–antigen pair associated with Felty's syndrome
Henrik J. Ditzel, Yasufumi Masaki, Heidi Nielsen, Lauge Farnaes, and Dennis R. Burton
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9234–9239.
PMCID: PMC16851
Microbiology
Snapshots of usher-mediated protein secretion and ordered pilus assembly
Evan T. Saulino, Esther Bullitt, and Scott J. Hultgren
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9240–9245. Published online 2000 July 25.
PMCID: PMC16852
The pleiotropic response regulator DegU functions as a priming protein in competence development in Bacillus subtilis
Leendert W. Hamoen, Aske F. Van Werkhoven, Gerard Venema, and David Dubnau
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9246–9251. Published online 2000 July 25.
PMCID: PMC16853
Coreceptor restriction within the HLA-DQ locus for Epstein–Barr virus infection
Keith M. Haan and Richard Longnecker
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9252–9257. Published online 2000 July 25.
PMCID: PMC16854
Lipophosphoglycan is a virulence factor distinct from related glycoconjugates in the protozoan parasite Leishmania major
Gerald F. Späth, Linda Epstein, Ben Leader, Steven M. Singer, Herbert A. Avila, Salvatore J. Turco, and Stephen M. Beverley
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9258–9263. Published online 2000 July 25.
PMCID: PMC16855
Neurobiology
Pseudorabies virus expressing enhanced green fluorescent protein: A tool for in vitro electrophysiological analysis of transsynaptically labeled neurons in identified central nervous system circuits
Bret N. Smith, Bruce W. Banfield, Cynthia A. Smeraski, Christine L. Wilcox, F. Edward Dudek, Lynn W. Enquist, and Gary E. Pickard
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9264–9269.
PMCID: PMC16856
Neuroprotective potential of a viral vector system induced by a neurological insult
Clare R. Ozawa, Jill J. Ho, David J. Tsai, Dora Y. Ho, and Robert M. Sapolsky
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9270–9275. Published online 2000 July 25.
PMCID: PMC16857
Subnucleus-specific loss of neurons in medial thalamus of schizophrenics
Gregory J. Popken, William E. Bunney, Jr., Steven G. Potkin, and Edward G. Jones
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9276–9280. Published online 2000 July 25.
PMCID: PMC16858
Learning about pain: The neural substrate of the prediction error for aversive events
Alexander Ploghaus, Irene Tracey, Stuart Clare, Joseph S. Gati, J. Nicholas P. Rawlins, and Paul M. Matthews
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9281–9286. Published online 2000 July 25.
PMCID: PMC16859
Spinophilin regulates the formation and function of dendritic spines
Jian Feng, Zhen Yan, Adriana Ferreira, Kazuhito Tomizawa, Jason A. Liauw, Min Zhuo, Patrick B. Allen, Charles C. Ouimet, and Paul Greengard
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9287–9292.
PMCID: PMC16860
The role of dynamic palmitoylation in Ca2+ channel inactivation
Joyce H. Hurley, Anne L. Cahill, Kevin P. M. Currie, and Aaron P. Fox
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9293–9298. Published online 2000 July 18.
PMCID: PMC16861
Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid β-protein generation
Weiming Xia, William J. Ray, Beth L. Ostaszewski, Talat Rahmati, W. Taylor Kimberly, Michael S. Wolfe, Jimin Zhang, Alison M. Goate, and Dennis J. Selkoe
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9299–9304.
PMCID: PMC16862
Pharmacology
Specific binding sites for alcohols and anesthetics on ligand-gated ion channels
Maria Paola Mascia, James R. Trudell, and R. Adron Harris
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9305–9310. Published online 2000 July 25.
PMCID: PMC16863
Role of C-terminal domains of the G protein β subunit in the activation of effectors
Chang-Seon Myung and James C. Garrison
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9311–9316.
PMCID: PMC16864
Physiology
Interleukin-6 is an essential, corticotropin-releasing hormone-independent stimulator of the adrenal axis during immune system activation
Kathleen E. Bethin, Sherri K. Vogt, and Louis J. Muglia
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9317–9322.
PMCID: PMC16865
Plant Biology
The Arabidopsis dnd1 “defense, no death” gene encodes a mutated cyclic nucleotide-gated ion channel
Steven J. Clough, Kevin A. Fengler, I-ching Yu, Bernadette Lippok, Roger K. Smith, Jr., and Andrew F. Bent
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9323–9328. Published online 2000 July 18.
PMCID: PMC16866
New roles for cis-jasmone as an insect semiochemical and in plant defense
Michael A. Birkett, Colin A. M. Campbell, Keith Chamberlain, Emilio Guerrieri, Alastair J. Hick, Janet L. Martin, Michaela Matthes, Johnathan A. Napier, Jan Pettersson, John A. Pickett, Guy M. Poppy, Eleanor M. Pow, Barry J. Pye, Lesley E. Smart, George H. Wadhams, Lester J. Wadhams, and Christine M. Woodcock
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9329–9334. Published online 2000 July 18.
PMCID: PMC16867
Population Biology
Etiology of interepidemic periods of mosquito-borne disease
Simon I. Hay, Monica F. Myers, Donald S. Burke, David W. Vaughn, Timothy Endy, Nisalak Ananda, G. Dennis Shanks, Robert W. Snow, and David J. Rogers
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9335–9339.
PMCID: PMC16868
Social Sciences
Social Sciences
A dynamic model of social network formation
Brian Skyrms and Robin Pemantle
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9340–9346.
PMCID: PMC16869
Corrections
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9347.
PMCID: PMC56048
Corrects: Shigeomi Shimizu, et al. BH4 domain of antiapoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell death. Proc Natl Acad Sci U S A. 2000 March 28; 97(7): 3100–3105.
Proc Natl Acad Sci U S A. 2000 August 1; 97(16): 9347. Published online 2000 July 18.
PMCID: PMC56049
Corrects: Norio Ishida, et al. Biological clocks. Proc Natl Acad Sci U S A. 1999 August 3; 96(16): 8819–8820.
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