| | This journal provides immediate access to some articles. Commentaries A stream's role in watershed nutrient export Robert O. Hall, Jr. PMCID: PMC193526 The subtleties of water in small spaces Thomas M. Truskett PMCID: PMC193527 Oxygen toxicity and the health and survival of eukaryote cells: A new
piece is added to the puzzle F. Archibald PMCID: PMC193528 Hormones are in the air Harry Klee PMCID: PMC193529 Physical Sciences Comparing the continuous representation of time-series expression profiles to identify differentially expressed genes Ziv Bar-Joseph, Georg Gerber, Itamar Simon, David K. Gifford, and Tommi S. Jaakkola PMCID: PMC193530 Applied Mathematics Short- and long-range effects of Sonic hedgehog in limb development Robert Dillon, Chetan Gadgil, and Hans G. Othmer PMCID: PMC193531 Applied Physical Sciences Increase in signal-to-noise ratio of > 10,000 times in liquid-state
NMR Jan H. Ardenkjær-Larsen, Björn Fridlund, Andreas Gram, Georg Hansson, Lennart Hansson, Mathilde H. Lerche, Rolf Servin, Mikkel Thaning, and Klaes Golman PMCID: PMC193532 Dielectrophoretic dynamic light-scattering (DDLS) spectroscopy Folim G. Halaka PMCID: PMC193533 Chemistry Self-assembly of synthetic peptides control conformation and optical
properties of a zwitterionic polythiophene derivative K. Peter R. Nilsson, Johan Rydberg, Lars Baltzer, and Olle Inganäs PMCID: PMC193534 Physics From the Cover:
Osmotic water transport through carbon nanotube membranes Amrit Kalra, Shekhar Garde, and Gerhard Hummer PMCID: PMC193535 Group interest versus self-interest in smallpox vaccination policy Chris T. Bauch, Alison P. Galvani, and David J. D. Earn PMCID: PMC193525 Biological Sciences Comparing the continuous representation of time-series expression profiles to identify differentially expressed genes Ziv Bar-Joseph, Georg Gerber, Itamar Simon, David K. Gifford, and Tommi S. Jaakkola PMCID: PMC193530 Agricultural Sciences The complete genome sequence of the Arabidopsis and tomato
pathogen Pseudomonas syringae pv. tomato DC3000 C. Robin Buell, Vinita Joardar, Magdalen Lindeberg, Jeremy Selengut, Ian T. Paulsen, Michelle L. Gwinn, Robert J. Dodson, Robert T. Deboy, A. Scott Durkin, James F. Kolonay, Ramana Madupu, Sean Daugherty, Lauren Brinkac, Maureen J. Beanan, Daniel H. Haft, William C. Nelson, Tanja Davidsen, Nikhat Zafar, Liwei Zhou, Jia Liu, Qiaoping Yuan, Hoda Khouri, Nadia Fedorova, Bao Tran, Daniel Russell, Kristi Berry, Teresa Utterback, Susan E. Van Aken, Tamara V. Feldblyum, Mark D'Ascenzo, Wen-Ling Deng, Adela R. Ramos, James R. Alfano, Samuel Cartinhour, Arun K. Chatterjee, Terrence P. Delaney, Sondra G. Lazarowitz, Gregory B. Martin, David J. Schneider, Xiaoyan Tang, Carol L. Bender, Owen White, Claire M. Fraser, and Alan Collmer PMCID: PMC193536 Biochemistry Intermolecular thiol cross-linking via loops in the lactose permease of
Escherichia coli Natalia Ermolova, Lan Guan, and H. Ronald Kaback PMCID: PMC193537 INAUGURAL ARTICLE by a Recently Elected Academy Member: A noncanonical sequence phosphorylated by casein kinase 1 in
β-catenin may play a role in casein kinase 1 targeting of important
signaling proteins Oriano Marin, Victor H. Bustos, Luca Cesaro, Flavio Meggio, Mario A. Pagano, Marcelo Antonelli, Catherine C. Allende, Lorenzo A. Pinna, and Jorge E. Allende PMCID: PMC193538 Reconstitution of recombination-dependent DNA synthesis in herpes simplex
virus 1 Amitabh V. Nimonkar and Paul E. Boehmer PMCID: PMC193539 Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and
diabetes induced by high-fat/high-carbohydrate diets Lutfi Abu-Elheiga, Wonkeun Oh, Parichher Kordari, and Salih J. Wakil PMCID: PMC193540 A tenth atp gene and the conserved atpI gene of a
Bacillus atp operon have a role in Mg2+ uptake David B. Hicks, ZhenXiong Wang, Yi Wei, Rebecca Kent, Arthur A. Guffanti, Horia Banciu, David H. Bechhofer, and Terry A. Krulwich PMCID: PMC193541 Glutamate-binding affinity of Drosophila metabotropic glutamate
receptor is modulated by association with lipid rafts Çagla Eroglu, Britta Brügger, Felix Wieland, and Irmgard Sinning PMCID: PMC193542 S-adenosyl-l-methionine is an effector in the
posttranscriptional autoregulation of the cystathionine γ-synthase gene
in Arabidopsis Yukako Chiba, Ryoko Sakurai, Michiko Yoshino, Kimihiro Ominato, Mari Ishikawa, Hitoshi Onouchi, and Satoshi Naito PMCID: PMC193543 Degradation of p57Kip2 mediated by
SCFSkp2-dependent ubiquitylation Takumi Kamura, Taichi Hara, Shuhei Kotoshiba, Masayoshi Yada, Noriko Ishida, Hiroyuki Imaki, Shigetsugu Hatakeyama, Keiko Nakayama, and Keiichi I. Nakayama PMCID: PMC193544 The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for
sister chromatid cohesion loads proliferating cell nuclear antigen onto
DNA Vladimir P. Bermudez, Yoshimasa Maniwa, Inger Tappin, Keiko Ozato, Kyoko Yokomori, and Jerard Hurwitz PMCID: PMC193545 Can energy landscape roughness of proteins and RNA be measured by using
mechanical unfolding experiments? Changbong Hyeon and D. Thirumalai PMCID: PMC193524 Biophysics Hydrogen atoms in proteins: Positions and dynamics Niklas Engler, Andreas Ostermann, Nobuo Niimura, and Fritz G. Parak PMCID: PMC193546 Can energy landscape roughness of proteins and RNA be measured by using
mechanical unfolding experiments? Changbong Hyeon and D. Thirumalai PMCID: PMC193524 Liquid-solid transition in nuclei of protein crystals Aleksey Lomakin, Neer Asherie, and George B. Benedek PMCID: PMC193547 Biomimetic organization: Octapeptide self-assembly into nanotubes of viral capsid-like dimension Céline Valéry, Maïté Paternostre, Bruno Robert, Thaddée Gulik-Krzywicki, Theyencheri Narayanan, Jean-Claude Dedieu, Gérard Keller, Maria-Luisa Torres, Roland Cherif-Cheikh, Pilar Calvo, and Franck Artzner PMCID: PMC193548 Cell Biology γ-Tubulin function during female germ-cell development and
oogenesis in Drosophila Gaia Tavosanis and Cayetano Gonzalez PMCID: PMC193549 Hierarchical model of gene regulation by transforming growth factor
β Yaw-Ching Yang, Ester Piek, Jiri Zavadil, Dan Liang, Donglu Xie, Joerg Heyer, Paul Pavlidis, Raju Kucherlapati, Anita B. Roberts, and Erwin P. Böttinger PMCID: PMC193550 ACE2 is required for daughter cell-specific G1 delay
in Saccharomyces cerevisiae Tracy L. Laabs, David D. Markwardt, Matthew G. Slattery, Laura L. Newcomb, David J. Stillman, and Warren Heideman PMCID: PMC193551 Modulation of DNA damage-induced apoptosis by cell adhesion is
independently mediated by p53 and c-Abl Tony Truong, Guizhen Sun, Michael Doorly, Jean Y. J. Wang, and Martin Alexander Schwartz PMCID: PMC193552 The yeasts Rho1p and Pkc1p regulate the transport of chitin synthase III
(Chs3p) from internal stores to the plasma membrane Raphael H. Valdivia and Randy Schekman PMCID: PMC193553 Developmental Biology Drosophila spalt/spalt-related mutants exhibit Townes-Brocks'
syndrome phenotypes P. D. Si Dong, Sokol V. Todi, Daniel F. Eberl, and Grace Boekhoff-Falk PMCID: PMC193554 Unsuspected role of the brain morphogenetic gene Otx1 in
hematopoiesis Elena Levantini, Alessandra Giorgetti, Francesco Cerisoli, Elisabetta Traggiai, Alessandra Guidi, Richard Martin, Dario Acampora, Peter D. Aplan, Gordon Keller, Antonio Simeone, Norman N. Iscove, Trang Hoang, and Maria Cristina Magli PMCID: PMC193555 Ecology From the Cover:
In-stream uptake dampens effects of major forest disturbance on watershed
nitrogen export E. S. Bernhardt, G. E. Likens, D. C. Buso, and C. T. Driscoll PMCID: PMC193556 Wilderness and biodiversity conservation R. A. Mittermeier, C. G. Mittermeier, T. M. Brooks, J. D. Pilgrim, W. R. Konstant, G. A. B. da Fonseca, and C. Kormos PMCID: PMC193557 Evolution Allopatric genetic origins for sympatric host-plant shifts and race
formation in Rhagoletis Jeffrey L. Feder, Stewart H. Berlocher, Joseph B. Roethele, Hattie Dambroski, James J. Smith, William L. Perry, Vesna Gavrilovic, Kenneth E. Filchak, Juan Rull, and Martin Aluja PMCID: PMC193558 Fatty acid biosynthesis in Mycobacterium tuberculosis: Lateral
gene transfer, adaptive evolution, and gene duplication Rhoda J. Kinsella, David A. Fitzpatrick, Christopher J. Creevey, and James O. McInerney PMCID: PMC193559 Stress promotes maleness in hermaphroditic modular animals R. N. Hughes, P. H. Manríquez, J. D. D. Bishop, and M. T. Burrows PMCID: PMC193560 From the Cover:
Genetic footprints of demographic expansion in North America, but not
Amazonia, during the Late Quaternary Enrique P. Lessa, Joseph A. Cook, and James L. Patton PMCID: PMC193561 Estimating the distribution of fitness effects from DNA sequence data:
Implications for the molecular clock Gwenaël Piganeau and Adam Eyre-Walker PMCID: PMC193562 Cuticular hydrocarbons mediate discrimination of reproductives and
nonreproductives in the ant Myrmecia gulosa Vincent Dietemann, Christian Peeters, Jürgen Liebig, Virginie Thivet, and Bert Hölldobler PMCID: PMC193563 Genetics Specific sequence changes in multiple transcript system DYT3 are
associated with X-linked dystonia parkinsonism Dagmar Nolte, Stephan Niemann, and Ulrich Müller PMCID: PMC193564 From the Cover:
Manganese activation of superoxide dismutase 2 in Saccharomyces
cerevisiae requires MTM1, a member of the mitochondrial carrier
family Edward Luk, Mark Carroll, Michelle Baker, and Valeria Cizewski Culotta PMCID: PMC193565 Homez, a homeobox leucine zipper gene specific to the vertebrate
lineage Dashzeveg Bayarsaihan, Badam Enkhmandakh, Aleksandr Makeyev, John M. Greally, James F. Leckman, and Frank H. Ruddle PMCID: PMC193566 Haplotype variation in bovine Toll-like receptor 4 and computational
prediction of a positively selected ligand-binding domain Stephen N. White, Kristen H. Taylor, Colette A. Abbey, Clare A. Gill, and James E. Womack PMCID: PMC193567 Expression deconvolution: A reinterpretation of DNA microarray data
reveals dynamic changes in cell populations Peng Lu, Aleksey Nakorchevskiy, and Edward M. Marcotte PMCID: PMC193568 Immunology Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis
and diabetes in the nonobese diabetic mouse Hiroaki Moriyama, Norio Abiru, Johanna Paronen, Kamila Sikora, Edwin Liu, Dongmei Miao, Devasenan Devendra, Joshua Beilke, Roberto Gianani, Ron G. Gill, and George S. Eisenbarth PMCID: PMC193569 Ian4 is required for mitochondrial integrity and T cell survival Malini Pandarpurkar, Leanne Wilson-Fritch, Silvia Corvera, Helle Markholst, Lars Hornum, Dale L. Greiner, John P. Mordes, Aldo A. Rossini, and Rita Bortell PMCID: PMC193570 B7x: A widely expressed B7 family member that inhibits T cell
activation Xingxing Zang, P'ng Loke, Jayon Kim, Kenneth Murphy, Rebecca Waitz, and James P. Allison PMCID: PMC193571 Medical Sciences Breast cancer classification and prognosis based on gene expression
profiles from a population-based study Christos Sotiriou, Soek-Ying Neo, Lisa M. McShane, Edward L. Korn, Philip M. Long, Amir Jazaeri, Philippe Martiat, Steve B. Fox, Adrian L. Harris, and Edison T. Liu PMCID: PMC193572 Kaposi's sarcoma-associated herpesvirus-infected primary effusion
lymphoma has a plasma cell gene expression profile Richard G. Jenner, Karine Maillard, Nicola Cattini, Robin A. Weiss, Chris Boshoff, Richard Wooster, and Paul Kellam PMCID: PMC193573 Estrogen deficiency induces bone loss by increasing T cell proliferation
and lifespan through IFN-γ-induced class II transactivator Simone Cenci, Gianluca Toraldo, M. Neale Weitzmann, Cristiana Roggia, Yuhao Gao, Wei Ping Qian, Oscar Sierra, and Roberto Pacifici PMCID: PMC193574 Rapamycin causes down-regulation of CCR5 and accumulation of anti-HIV
β-chemokines: An approach to suppress R5 strains of HIV-1 A. Heredia, A. Amoroso, C. Davis, N. Le, E. Reardon, J. K. Dominique, E. Klingebiel, R. C. Gallo, and R. R. Redfield PMCID: PMC193575 Alzheimer's disease-affected brain: Presence of oligomeric Aβ
ligands (ADDLs) suggests a molecular basis for reversible memory loss Yuesong Gong, Lei Chang, Kirsten L. Viola, Pascale N. Lacor, Mary P Lambert, Caleb E. Finch, Grant A. Krafft, and William L. Klein PMCID: PMC193576 Niemann-Pick C heterozygosity confers resistance to lesional necrosis and
macrophage apoptosis in murine atherosclerosis Bo Feng, Dajun Zhang, George Kuriakose, Cecillia M. Devlin, Mark Kockx, and Ira Tabas PMCID: PMC193577 WNT7a induces E-cadherin in lung cancer cells Tatsuo Ohira, Robert M. Gemmill, Kevin Ferguson, Sophie Kusy, Joëlle Roche, Elisabeth Brambilla, Chan Zeng, Anna Baron, Lynne Bemis, Paul Erickson, Elizabeth Wilder, Anil Rustgi, Jan Kitajewski, Edward Gabrielson, Roy Bremnes, Wilbur Franklin, and Harry A. Drabkin PMCID: PMC193578 Molecular imaging with endogenous substances Klaes Golman, Jan H. Ardenkjær-Larsen, J. Stefan Petersson, Sven Månsson, and Ib Leunbach PMCID: PMC193579 From the Cover:
Intense myocyte formation from cardiac stem cells in human cardiac
hypertrophy Konrad Urbanek, Federico Quaini, Giordano Tasca, Daniele Torella, Clotilde Castaldo, Bernardo Nadal-Ginard, Annarosa Leri, Jan Kajstura, Eugenio Quaini, and Piero Anversa PMCID: PMC193580 Microbiology Mpi recombinase globally modulates the surface architecture of a human
commensal bacterium Michael J. Coyne, Katja G. Weinacht, Corinna M. Krinos, and Laurie E. Comstock PMCID: PMC193581 INAUGURAL ARTICLE by a Recently Elected Academy Member: Honor thy symbionts Jian Xu and Jeffrey I. Gordon PMCID: PMC193582 DNA vaccine coding for the full-length infectious Kunjin virus RNA
protects mice against the New York strain of West Nile virus Roy A. Hall, Debra J. Nisbet, Kim B. Pham, Alyssa T. Pyke, Greg A. Smith, and Alexander A. Khromykh PMCID: PMC193583 Conjugative coupling proteins interact with cognate and heterologous
VirB10-like proteins while exhibiting specificity for cognate
relaxosomes Matxalen Llosa, Sandra Zunzunegui, and Fernando de la Cruz PMCID: PMC193584 Role and location of the unusual redox-active cysteines in the
hydrophobic domain of the transmembrane electron transporter DsbD Federico Katzen and Jon Beckwith PMCID: PMC193585 Chaperone-mediated in vitro assembly of Polyomavirus
capsids Laura R. Chromy, James M. Pipas, and Robert L. Garcea PMCID: PMC193586 Neuroscience Minocycline inhibits caspase-independent and -dependent mitochondrial
cell death pathways in models of Huntington's disease Xin Wang, Shan Zhu, Martin Drozda, Wenhua Zhang, Irina G. Stavrovskaya, Elena Cattaneo, Robert J. Ferrante, Bruce S. Kristal, and Robert M. Friedlander PMCID: PMC193587 Participation of the S4 voltage sensor in the Mg2+-dependent activation of large conductance (BK) K+ channels Lei Hu, Jingyi Shi, Zhongming Ma, Gayathri Krishnamoorthy, Fred Sieling, Guangping Zhang, Frank T. Horrigan, and Jianmin Cui PMCID: PMC193588 Synaptopodin-deficient mice lack a spine apparatus and show deficits in synaptic plasticity Thomas Deller, Martin Korte, Sophie Chabanis, Alexander Drakew, Herbert Schwegler, Giulia Good Stefani, Aimee Zuniga, Karin Schwarz, Tobias Bonhoeffer, Rolf Zeller, Michael Frotscher, and Peter Mundel PMCID: PMC193589 Brain potentials associated with conscious aftereffects induced by unseen
stimuli in a blindsight subject L. Weiskrantz, A. Rao, I. Hodinott-Hill, A. C. Nobre, and A. Cowey PMCID: PMC193590 Divergent impact of progesterone and medroxyprogesterone acetate
(Provera) on nuclear mitogen-activated protein kinase signaling Jon Nilsen and Roberta Diaz Brinton PMCID: PMC193591 An ultrasensitive Ca2+/calmodulin-dependent protein kinase
II-protein phosphatase 1 switch facilitates specificity in postsynaptic
calcium signaling J. Michael Bradshaw, Yoshi Kubota, Tobias Meyer, and Howard Schulman PMCID: PMC193592 A mouse model of Rubinstein-Taybi syndrome: Defective long-term memory is
ameliorated by inhibitors of phosphodiesterase 4 Rusiko Bourtchouladze, Regina Lidge, Ray Catapano, Jennifer Stanley, Scott Gossweiler, Darlene Romashko, Rod Scott, and Tim Tully PMCID: PMC193593 Amphetamine or cocaine limits the ability of later experience to promote
structural plasticity in the neocortex and nucleus accumbens Bryan Kolb, Grazyna Gorny, Yilin Li, Anne-Noël Samaha, and Terry E. Robinson PMCID: PMC193594 Pharmacology Activation of CB2 cannabinoid receptors by AM1241 inhibits
experimental neuropathic pain: Pain inhibition by receptors not present in the
CNS Mohab M. Ibrahim, Hongfeng Deng, Alexander Zvonok, Debra A. Cockayne, Joyce Kwan, Heriberto P. Mata, Todd W. Vanderah, Josephine Lai, Frank Porreca, Alexandros Makriyannis, and T. Philip Malan, Jr. PMCID: PMC193595 Physiology Gating currents associated with intramembrane charge displacement in HERG
potassium channels David R. Piper, Anthony Varghese, Michael C. Sanguinetti, and Martin Tristani-Firouzi PMCID: PMC193596 Targeted disruption of GPR7, the endogenous receptor for neuropeptides B and W, leads to metabolic defects and adult-onset obesity Makoto Ishii, Hong Fei, and Jeffrey M. Friedman PMCID: PMC193597 HILS1 is a spermatid-specific linker histone H1-like protein implicated
in chromatin remodeling during mammalian spermiogenesis Wei Yan, Lang Ma, Kathleen H. Burns, and Martin M. Matzuk PMCID: PMC193598 Plant Biology Simultaneous analysis of phytohormones, phytotoxins, and volatile organic
compounds in plants Eric A. Schmelz, Juergen Engelberth, Hans T. Alborn, Phillip O'Donnell, Matt Sammons, Hiroaki Toshima, and James H. Tumlinson, III PMCID: PMC193599 A calmodulin-binding protein from Arabidopsis has an essential
role in pollen germination Maxim Golovkin and Anireddy S. N. Reddy PMCID: PMC193600 Group interest versus self-interest in smallpox vaccination policy Chris T. Bauch, Alison P. Galvani, and David J. D. Earn PMCID: PMC193525 Social Sciences Psychology Development of object concepts in infancy: Evidence for early learning in an eye-tracking paradigm Scott P. Johnson, Dima Amso, and Jonathan A. Slemmer PMCID: PMC193601 Social Sciences Effectiveness of diabetes mellitus screening recommendations Florence J. Dallo and Susan C. Weller PMCID: PMC193602 Correction Proc Natl Acad Sci U S A. 2003 September 2; 100(18): 10580. doi: 10.1073/pnas.1733901100.PMCID: PMC193603 Corrects: Jens Bredenbeck, et al. Picosecond conformational transition and equilibration of a cyclic peptide. Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6452–6457. |
