| | This journal provides immediate access to some articles. Commentaries The specifics of small interfering RNA specificity Andrew Dillin Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6289–6291. Published online 2003 May 16. doi: 10.1073/pnas.1232238100.PMCID: PMC164437 A fratricidal fungal prion David D. Perkins Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6292–6294. Published online 2003 May 16. doi: 10.1073/pnas.1332353100.PMCID: PMC164438 Suppression of macrophage inflammatory responses by PPARs Peter Henson Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6295–6296. Published online 2003 May 19. doi: 10.1073/pnas.1232410100.PMCID: PMC164439 Physical Sciences Applied Physical Sciences Beyond superquenching: Hyper-efficient energy transfer from conjugated polymers to gold nanoparticles Chunhai Fan, Shu Wang, Janice W. Hong, Guillermo C. Bazan, Kevin W. Plaxco, and Alan J. Heeger Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6297–6301. Published online 2003 May 15. doi: 10.1073/pnas.1132025100.PMCID: PMC164440 Chemistry Interaction of antimicrobial peptide protegrin with biomembranes David Gidalevitz, Yuji Ishitsuka, Adrian S. Muresan, Oleg Konovalov, Alan J. Waring, Robert I. Lehrer, and Ka Yee C. Lee Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6302–6307. Published online 2003 May 8. doi: 10.1073/pnas.0934731100.PMCID: PMC164441 Engineering Retrofitting existing chemical scrubbers to biotrickling filters for H2S emission control David Gabriel and Marc A. Deshusses Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6308–6312. Published online 2003 May 9. doi: 10.1073/pnas.0731894100.PMCID: PMC164442 Mathematics Spectra of random graphs with given expected degrees Fan Chung, Linyuan Lu, and Van Vu Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6313–6318. Published online 2003 May 12. doi: 10.1073/pnas.0937490100.PMCID: PMC164443 Biological Sciences Applied Biological Sciences Global atmospheric black carbon inferred from AERONET Makiko Sato, James Hansen, Dorothy Koch, Andrew Lacis, Reto Ruedy, Oleg Dubovik, Brent Holben, Mian Chin, and Tica Novakov Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6319–6324. Published online 2003 May 13. doi: 10.1073/pnas.0731897100.PMCID: PMC164444 Spontaneous mitotic homologous recombination at an enhanced yellow fluorescent protein (EYFP) cDNA direct repeat in transgenic mice Carrie A. Hendricks, Karen H. Almeida, Molly S. Stitt, Vidya S. Jonnalagadda, Rebecca E. Rugo, G. Foster Kerrison, and Bevin P. Engelward Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6325–6330. Published online 2003 May 15. doi: 10.1073/pnas.1232231100.PMCID: PMC164445 Interaction of soft condensed materials with living cells: Phenotype/transcriptome correlations for the hydrophobic effect Lorcan T. Allen, Edward J. P. Fox, Irena Blute, Zoe D. Kelly, Yuri Rochev, Alan K. Keenan, Kenneth A. Dawson, and William M. Gallagher Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6331–6336. Published online 2003 May 13. doi: 10.1073/pnas.1031426100.PMCID: PMC164446 Biochemistry ATP hydrolysis on actin-related protein 2/3 complex causes debranching of dendritic actin arrays Christophe Le Clainche, Dominique Pantaloni, and Marie-France Carlier Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6337–6342. Published online 2003 May 12. doi: 10.1073/pnas.1130513100.PMCID: PMC164447 From the Cover: Genomewide view of gene silencing by small interfering RNAs Jen-Tsan Chi, Howard Y. Chang, Nancy N. Wang, Dustin S. Chang, Nina Dunphy, and Patrick O. Brown Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6343–6346. Published online 2003 May 2. doi: 10.1073/pnas.1037853100.PMCID: PMC164448 From the Cover: Specificity of short interfering RNA determined through gene expression signatures Dimitri Semizarov, Leigh Frost, Aparna Sarthy, Paul Kroeger, Donald N. Halbert, and Stephen W. Fesik Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6347–6352. Published online 2003 May 13. doi: 10.1073/pnas.1131959100.PMCID: PMC164449 Programming peptidomimetic syntheses by translating genetic codes designed de novo Anthony C. Forster, Zhongping Tan, Madhavi N. L. Nalam, Hening Lin, Hui Qu, Virginia W. Cornish, and Stephen C. Blacklow Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6353–6357. Published online 2003 May 16. doi: 10.1073/pnas.1132122100.PMCID: PMC164450 Fatty acid synthesis is essential in embryonic development: Fatty acid synthase null mutants and most of the heterozygotes die in utero Subrahmanyam S. Chirala, Hua Chang, Martin Matzuk, Lutfi Abu-Elheiga, Jianqiang Mao, Kathleen Mahon, Milton Finegold, and Salih J. Wakil Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6358–6363. Published online 2003 May 8. doi: 10.1073/pnas.0931394100.PMCID: PMC164451 Genomewide demarcation of RNA polymerase II transcription units revealed by physical fractionation of chromatin Peter L. Nagy, Michael L. Cleary, Patrick O. Brown, and Jason D. Lieb Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6364–6369. Published online 2003 May 15. doi: 10.1073/pnas.1131966100.PMCID: PMC164452 Spherical aggregates of β-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3β Minako Hoshi, Michio Sato, Shinichiro Matsumoto, Akihiko Noguchi, Kaori Yasutake, Natsuko Yoshida, and Kazuki Sato Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6370–6375. Published online 2003 May 15. doi: 10.1073/pnas.1237107100.PMCID: PMC164453 Structural and biochemical studies of p21Ras S-nitrosylation and nitric oxide-mediated guanine nucleotide exchange Jason G. Williams, Kamesh Pappu, and Sharon L. Campbell Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6376–6381. Published online 2003 May 9. doi: 10.1073/pnas.1037299100.PMCID: PMC164454 γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2 W. Taylor Kimberly, Matthew J. LaVoie, Beth L. Ostaszewski, Wenjuan Ye, Michael S. Wolfe, and Dennis J. Selkoe Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6382–6387. Published online 2003 May 9. doi: 10.1073/pnas.1037392100.PMCID: PMC164455 Quality control of ribosomal RNA mediated by polynucleotide phosphorylase and RNase R Zhuan-Fen Cheng and Murray P. Deutscher Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6388–6393. Published online 2003 May 12. doi: 10.1073/pnas.1231041100.PMCID: PMC164456 Understanding tubulin–Taxol interactions: Mutations that impart Taxol binding to yeast tubulin Mohan L. Gupta, Jr., Claudia J. Bode, Gunda I. Georg, and Richard H. Himes Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6394–6397. Published online 2003 May 9. doi: 10.1073/pnas.1131967100.PMCID: PMC164457 Vam10p defines a Sec18p-independent step of priming that allows yeast vacuole tethering Masashi Kato and William Wickner Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6398–6403. Published online 2003 May 14. doi: 10.1073/pnas.1132162100.PMCID: PMC164458 Molecular genetic analysis of the glycosyltransferase Fringe in Drosophila Trudy Correia, Venizelos Papayannopoulos, Vladislav Panin, Pamela Woronoff, Jin Jiang, Thomas F. Vogt, and Kenneth D. Irvine Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6404–6409. Published online 2003 May 12. doi: 10.1073/pnas.1131007100.PMCID: PMC164459 How the BfiI restriction enzyme uses one active site to cut two DNA strands Giedrius Sasnauskas, Stephen E. Halford, and Virginijus Siksnys Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6410–6415. Published online 2003 May 15. doi: 10.1073/pnas.1131003100.PMCID: PMC164460 Exponential growth by cross-catalytic cleavage of deoxyribozymogens Matthew Levy and Andrew D. Ellington Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6416–6421. Published online 2003 May 12. doi: 10.1073/pnas.1130145100.PMCID: PMC164461 TRAP230/ARC240 and TRAP240/ARC250 Mediator subunits are functionally conserved through evolution Camilla O. Samuelsen, Vera Baraznenok, Olga Khorosjutina, Henrik Spåhr, Thomas Kieselbach, Steen Holmberg, and Claes M. Gustafsson Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6422–6427. Published online 2003 May 8. doi: 10.1073/pnas.1030497100.PMCID: PMC164462 Chloride, not sodium, stimulates expression of the γ subunit of Na/K-ATPase and activates JNK in response to hypertonicity in mouse IMCD3 cells Juan M. Capasso, Christopher J. Rivard, Laura M. Enomoto, and Tomas Berl Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6428–6433. Published online 2003 May 13. doi: 10.1073/pnas.1130871100.PMCID: PMC164463 Biophysics The working stroke upon myosin–nucleotide complexes binding to actin Walter Steffen, David Smith, and John Sleep Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6434–6439. Published online 2003 May 15. doi: 10.1073/pnas.1231998100.PMCID: PMC164464 Structural basis of albumin–thyroxine interactions and familial dysalbuminemic hyperthyroxinemia Isabelle Petitpas, Charles E. Petersen, Chung-Eun Ha, Ananyo A. Bhattacharya, Patricia A. Zunszain, Jamie Ghuman, Nadhipuram V. Bhagavan, and Stephen Curry Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6440–6445. Published online 2003 May 12. doi: 10.1073/pnas.1137188100.PMCID: PMC164465 Structural defects and the diagnosis of amyloidogenic propensity Ariel Fernández, József Kardos, L. Ridgway Scott, Yuji Goto, and R. Stephen Berry Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6446–6451. Published online 2003 May 12. doi: 10.1073/pnas.0731893100.PMCID: PMC164466 Picosecond conformational transition and equilibration of a cyclic peptide Jens Bredenbeck, Jan Helbing, Arne Sieg, Tobias Schrader, Wolfgang Zinth, Christian Renner, Raymond Behrendt, Luis Moroder, Josef Wachtveitl, and Peter Hamm Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6452–6457. Published online 2003 May 7. doi: 10.1073/pnas.1036583100.PMCID: PMC164467 Structure of the coat protein in fd filamentous bacteriophage particles determined by solid-state NMR spectroscopy Ana Carolina Zeri, Michael F. Mesleh, Alexander A. Nevzorov, and Stanley J. Opella Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6458–6463. Published online 2003 May 15. doi: 10.1073/pnas.1132059100.PMCID: PMC164468 Cell Biology Specific protein methylation defects and gene expression perturbations in coactivator-associated arginine methyltransferase 1-deficient mice Neelu Yadav, Jaeho Lee, Jeesun Kim, Jianjun Shen, Mickey C.-T. Hu, C. Marcelo Aldaz, and Mark T. Bedford Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6464–6468. Published online 2003 May 19. doi: 10.1073/pnas.1232272100.PMCID: PMC164469 Exo1: A new chemical inhibitor of the exocytic pathway Yan Feng, Sidney Yu, Troy K. R. Lasell, Ashutosh P. Jadhav, Eric Macia, Pierre Chardin, Paul Melancon, Michael Roth, Timothy Mitchison, and Tomas Kirchhausen Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6469–6474. Published online 2003 May 8. doi: 10.1073/pnas.0631766100.PMCID: PMC164470 An actin–ribonucleoprotein interaction is involved in transcription by RNA polymerase II Piergiorgio Percipalle, Nathalie Fomproix, Karin Kylberg, Francesc Miralles, Birgitta Björkroth, Bertil Daneholt, and Neus Visa Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6475–6480. Published online 2003 May 12. doi: 10.1073/pnas.1131933100.PMCID: PMC164471 Abnormal phagocytosis by retinal pigmented epithelium that lacks myosin VIIa, the Usher syndrome 1B protein Daniel Gibbs, Junko Kitamoto, and David S. Williams Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6481–6486. Published online 2003 May 12. doi: 10.1073/pnas.1130432100.PMCID: PMC164472 Spermatogonial stem cells share some, but not all, phenotypic and functional characteristics with other stem cells Hiroshi Kubota, Mary R. Avarbock, and Ralph L. Brinster Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6487–6492. Published online 2003 May 8. doi: 10.1073/pnas.0631767100.PMCID: PMC164473 Compression forces generated by actin comet tails on lipid vesicles Paula A. Giardini, Daniel A. Fletcher, and Julie A. Theriot Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6493–6498. Published online 2003 May 8. doi: 10.1073/pnas.1031670100.PMCID: PMC164474 Dictyostelium and Acanthamoeba myosin II assembly domains go to the cleavage furrow of Dictyostelium myosin II-null cells Shi Shu, Xiong Liu, and Edward D. Korn Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6499–6504. Published online 2003 May 14. doi: 10.1073/pnas.0732155100.PMCID: PMC164475 Epidermal growth factor receptor signaling intensity determines intracellular protein interactions, ubiquitination, and internalization Mirko H. H. Schmidt, Frank B. Furnari, Webster K. Cavenee, and Oliver Bögler Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6505–6510. Published online 2003 May 6. doi: 10.1073/pnas.1031790100.PMCID: PMC164476 The phosphorylation of caveolin-2 on serines 23 and 36 modulates caveolin-1-dependent caveolae formation Grzegorz Sowa, Marc Pypaert, David Fulton, and William C. Sessa Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6511–6516. Published online 2003 May 12. doi: 10.1073/pnas.1031672100.PMCID: PMC164477 The basic helix–loop–helix–PAS protein ARNT functions as a potent coactivator of estrogen receptor-dependent transcription Sara Brunnberg, Katarina Pettersson, Elin Rydin, Jason Matthews, Annika Hanberg, and Ingemar Pongratz Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6517–6522. Published online 2003 May 16. doi: 10.1073/pnas.1136688100.PMCID: PMC164478 Cytokines and BCR-ABL mediate suppression of TRAIL-induced apoptosis through inhibition of forkhead FOXO3a transcription factor Saghi Ghaffari, Zainab Jagani, Claire Kitidis, Harvey F. Lodish, and Roya Khosravi-Far Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6523–6528. Published online 2003 May 15. doi: 10.1073/pnas.0731871100.PMCID: PMC164479 Targeting Ras signaling through inhibition of carboxyl methylation: An unexpected property of methotrexate Ann M. Winter-Vann, Barton A. Kamen, Martin O. Bergo, Stephen G. Young, Stepan Melnyk, S. Jill James, and Patrick J. Casey Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6529–6534. Published online 2003 May 15. doi: 10.1073/pnas.1135239100.PMCID: PMC164480 Developmental Biology Positional cloning of the young mutation identifies an essential role for the Brahma chromatin remodeling complex in mediating retinal cell differentiation Ronald G. Gregg, Gregory B. Willer, James M. Fadool, John E. Dowling, and Brian A. Link Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6535–6540. Published online 2003 May 14. doi: 10.1073/pnas.0631813100.PMCID: PMC164481 Development of teeth in chick embryos after mouse neural crest transplantations Thimios A. Mitsiadis, Yvonnick Chéraud, Paul Sharpe, and Josiane Fontaine-Pérus Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6541–6545. Published online 2003 May 9. doi: 10.1073/pnas.1137104100.PMCID: PMC164482 Rb function in extraembryonic lineages suppresses apoptosis in the CNS of Rb-deficient mice Alain de Bruin, Lizhao Wu, Harold I. Saavedra, Pamela Wilson, Ying Yang, Thomas J. Rosol, Michael Weinstein, Michael L. Robinson, and Gustavo Leone Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6546–6551. Published online 2003 May 5. doi: 10.1073/pnas.1031853100.PMCID: PMC164483 sal1 determines the number of aleurone cell layers in maize endosperm and encodes a class E vacuolar sorting protein Bo Shen, Changjiang Li, Zhao Min, Robert B. Meeley, Mitchell C. Tarczynski, and Odd-Arne Olsen Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6552–6557. Published online 2003 May 15. doi: 10.1073/pnas.0732023100.PMCID: PMC164484 Functional divergence within the APETALA3/PISTILLATA floral homeotic gene lineages Rebecca S. Lamb and Vivian F. Irish Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6558–6563. Published online 2003 May 13. doi: 10.1073/pnas.0631708100.PMCID: PMC164485 Ecology Biocomplexity and fisheries sustainability Ray Hilborn, Thomas P. Quinn, Daniel E. Schindler, and Donald E. Rogers Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6564–6568. Published online 2003 May 12. doi: 10.1073/pnas.1037274100.PMCID: PMC164486 Evolution Molecular paleontology of transposable elements in the Drosophila melanogaster genome Vladimir V. Kapitonov and Jerzy Jurka Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6569–6574. Published online 2003 May 12. doi: 10.1073/pnas.0732024100.PMCID: PMC164487 Evolution of the army ant syndrome: The origin and long-term evolutionary stasis of a complex of behavioral and reproductive adaptations Seán G. Brady Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6575–6579. Published online 2003 May 15. doi: 10.1073/pnas.1137809100.PMCID: PMC164488 A new Drosophila spliceosomal intron position is common in plants Rosa Tarrío, Francisco Rodríguez-Trelles, and Francisco J. Ayala Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6580–6583. Published online 2003 May 15. doi: 10.1073/pnas.0731952100.PMCID: PMC164489 Mate choice theory and the mode of selection in sexual populations Hampton L. Carson Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6584–6587. Published online 2003 May 12. doi: 10.1073/pnas.0732174100.PMCID: PMC164490 Tracing the origin and history of the HIV-2 epidemic Philippe Lemey, Oliver G. Pybus, Bin Wang, Nitin K. Saksena, Marco Salemi, and Anne-Mieke Vandamme Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6588–6592. Published online 2003 May 12. doi: 10.1073/pnas.0936469100.PMCID: PMC164491 From the Cover: Evidence for a genetic discontinuity between Neandertals and 24,000-year-old anatomically modern Europeans David Caramelli, Carles Lalueza-Fox, Cristiano Vernesi, Martina Lari, Antonella Casoli, Francesco Mallegni, Brunetto Chiarelli, Isabelle Dupanloup, Jaume Bertranpetit, Guido Barbujani, and Giorgio Bertorelle Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6593–6597. Published online 2003 May 12. doi: 10.1073/pnas.1130343100.PMCID: PMC164492 Sympatric speciation as a consequence of male pregnancy in seahorses Adam G. Jones, Glenn I. Moore, Charlotta Kvarnemo, DeEtte Walker, and John C. Avise Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6598–6603. Published online 2003 May 5. doi: 10.1073/pnas.1131969100.PMCID: PMC164493 Genetics Instability of GGL domain-containing RGS proteins in mice lacking the G protein β-subunit Gβ5 Ching-Kang Chen, Pamela Eversole-Cire, Haikun Zhang, Valeria Mancino, Yu-Jiun Chen, Wei He, Theodore G. Wensel, and Melvin I. Simon Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6604–6609. Published online 2003 May 8. doi: 10.1073/pnas.0631825100.PMCID: PMC164494 Susceptibility to tuberculosis: A locus on mouse chromosome 19 (Trl-4) regulates Mycobacterium tuberculosis replication in the lungs Loukia-Maria Mitsos, Lon R. Cardon, Lynn Ryan, Ronald LaCourse, Robert J. North, and Philippe Gros Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6610–6615. Published online 2003 May 9. doi: 10.1073/pnas.1031727100.PMCID: PMC164495 From the Cover: Sexual transmission of the [Het-s] prion leads to meiotic drive in Podospora anserina Henk J. P. Dalstra, Klaas Swart, Alfons J. M. Debets, Sven J. Saupe, and Rolf F. Hoekstra Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6616–6621. Published online 2003 April 28. doi: 10.1073/pnas.1030058100.PMCID: PMC164496 Coincidence of synteny breakpoints with malignancy-related deletions on human chromosome 3 Maria Kost-Alimova, Hajnalka Kiss, Ludmila Fedorova, Ying Yang, Jan P. Dumanski, George Klein, and Stefan Imreh Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6622–6627. Published online 2003 May 8. doi: 10.1073/pnas.0430971100.PMCID: PMC164497 Subcellular localization of yeast ribonucleotide reductase regulated by the DNA replication and damage checkpoint pathways Ruojin Yao, Zhen Zhang, Xiuxiang An, Brigid Bucci, Deborah L. Perlstein, JoAnne Stubbe, and Mingxia Huang Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6628–6633. Published online 2003 May 5. doi: 10.1073/pnas.1131932100.PMCID: PMC164498 Purine synthesis and increased Agrobacterium tumefaciens transformation of yeast and plants Radclyffe L. Roberts, Matthew Metz, Dave E. Monks, Matthew Lockwood Mullaney, Tyler Hall, and Eugene W. Nester Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6634–6639. Published online 2003 May 9. doi: 10.1073/pnas.1132022100.PMCID: PMC164499 Saccharomyces cerevisiae chromatin-assembly factors that act during DNA replication function in the maintenance of genome stability Kyungjae Myung, Vincent Pennaneach, Ellen S. Kats, and Richard D. Kolodner Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6640–6645. Published online 2003 May 15. doi: 10.1073/pnas.1232239100.PMCID: PMC164500 Immunology Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: Activation of Toll-like receptor 7 Jongdae Lee, Tsung-Hsien Chuang, Vanessa Redecke, Liping She, Paula M. Pitha, Dennis A. Carson, Eyal Raz, and Howard B. Cottam Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6646–6651. Published online 2003 May 8. doi: 10.1073/pnas.0631696100.PMCID: PMC164501 A fragment of anthrax lethal factor delivers proteins to the cytosol without requiring protective antigen Nicholas Kushner, Dong Zhang, Neal Touzjian, Max Essex, Judy Lieberman, and Yichen Lu Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6652–6657. Published online 2003 May 9. doi: 10.1073/pnas.1131930100.PMCID: PMC164502 T helper type 1 lymphocytes drive inflammation in human atherosclerotic lesions Marisa Benagiano, Annalisa Azzurri, Alessandra Ciervo, Amedeo Amedei, Carlo Tamburini, Mauro Ferrari, John L. Telford, Cosima T. Baldari, Sergio Romagnani, Antonio Cassone, Mario M. D'Elios, and Gianfranco Del Prete Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6658–6663. Published online 2003 May 9. doi: 10.1073/pnas.1135726100.PMCID: PMC164503 Human cathepsin S, but not cathepsin L, degrades efficiently MHC class II-associated invariant chain in nonprofessional APCs Jacek Bania, Evelina Gatti, Hugues Lelouard, Alexandre David, Fanny Cappello, Ekkehard Weber, Voahirana Camosseto, and Philippe Pierre Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6664–6669. Published online 2003 May 14. doi: 10.1073/pnas.1131604100.PMCID: PMC164504 Direct stimulation of naïve T cells by membrane vesicles from antigen-presenting cells: Distinct roles for CD54 and B7 molecules Inkyu Hwang, Xuefei Shen, and Jonathan Sprent Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6670–6675. Published online 2003 May 12. doi: 10.1073/pnas.1131852100.PMCID: PMC164505 A dual altered peptide ligand down-regulates myasthenogenic T cell responses by up-regulating CD25- and CTLA-4-expressing CD4+ T cells Miri Paas-Rozner, Michael Sela, and Edna Mozes Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6676–6681. Published online 2003 May 12. doi: 10.1073/pnas.1131898100.PMCID: PMC164506 Spontaneous regression of advanced cancer: Identification of a unique genetically determined, age-dependent trait in mice Zheng Cui, Mark C. Willingham, Amy M. Hicks, Martha A. Alexander-Miller, Timothy D. Howard, Gregory A. Hawkins, Mark S. Miller, Holly M. Weir, Wei Du, and Cynthia J. DeLong Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6682–6687. Published online 2003 April 30. doi: 10.1073/pnas.1031601100.PMCID: PMC164507 Beta cell MHC class I is a late requirement for diabetes Emma E. Hamilton-Williams, Stephanie E. Palmer, Brett Charlton, and Robyn M. Slattery Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6688–6693. Published online 2003 May 15. doi: 10.1073/pnas.1131954100.PMCID: PMC164508 Medical Sciences Disruption of the estrogen receptor β gene in mice causes myeloproliferative disease resembling chronic myeloid leukemia with lymphoid blast crisis Gil-Jin Shim, Ling Wang, Sandra Andersson, Noémi Nagy, Loránd Levente Kis, Qinghong Zhang, Sari Mäkelä, Margaret Warner, and Jan-Åke Gustafsson Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6694–6699. Published online 2003 May 9. doi: 10.1073/pnas.0731830100.PMCID: PMC164509 Copper chelation represses the vascular response to injury Lazar Mandinov, Anna Mandinova, Stanimir Kyurkchiev, Dobroslav Kyurkchiev, Ivan Kehayov, Vihren Kolev, Raffaella Soldi, Cinzia Bagala, Ebo D. de Muinck, Volkhard Lindner, Mark J. Post, Michael Simons, Stephen Bellum, Igor Prudovsky, and Thomas Maciag Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6700–6705. Published online 2003 May 16. doi: 10.1073/pnas.1231994100.PMCID: PMC164510 Gastrointestinal stromal tumors in a mouse model by targeted mutation of the Kit receptor tyrosine kinase Gunhild Sommer, Valter Agosti, Imke Ehlers, Ferdinand Rossi, Selim Corbacioglu, Judith Farkas, Malcolm Moore, Katia Manova, Cristina R. Antonescu, and Peter Besmer Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6706–6711. Published online 2003 May 16. doi: 10.1073/pnas.1037763100.PMCID: PMC164511 From the Cover: PPARγ and PPARδ negatively regulate specific subsets of lipopolysaccharide and IFN-γ target genes in macrophages John S. Welch, Mercedes Ricote, Taro E. Akiyama, Frank J. Gonzalez, and Christopher K. Glass Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6712–6717. Published online 2003 May 9. doi: 10.1073/pnas.1031789100.PMCID: PMC164512 Inhibition of p53-induced apoptosis without affecting expression of p53-regulated genes Joseph Lotem, Hilah Gal, Rachel Kama, Ninette Amariglio, Gideon Rechavi, Eytan Domany, Leo Sachs, and David Givol Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6718–6723. Published online 2003 May 12. doi: 10.1073/pnas.1031695100.PMCID: PMC164513 Adoptive transfer of apoptotic splenocytes worsens survival, whereas adoptive transfer of necrotic splenocytes improves survival in sepsis Richard S. Hotchkiss, Katherine C. Chang, Mitchell H. Grayson, Kevin W. Tinsley, Benjamin S. Dunne, Christopher G. Davis, Dale F. Osborne, and Irene E. Karl Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6724–6729. Published online 2003 May 7. doi: 10.1073/pnas.1031788100.PMCID: PMC164514 β3 integrin deficiency promotes atherosclerosis and pulmonary inflammation in high-fat-fed, hyperlipidemic mice Sherry Weng, Laura Zemany, Kara N. Standley, Deborah V. Novack, Marie La Regina, Carlos Bernal-Mizrachi, Trey Coleman, and Clay F. Semenkovich Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6730–6735. Published online 2003 May 13. doi: 10.1073/pnas.1137612100.PMCID: PMC164515 An EP2 receptor-selective prostaglandin E2 agonist induces bone healing V. M. Paralkar, F. Borovecki, H. Z. Ke, K. O. Cameron, B. Lefker, W. A. Grasser, T. A. Owen, M. Li, P. DaSilva-Jardine, M. Zhou, R. L. Dunn, F. Dumont, R. Korsmeyer, P. Krasney, T. A. Brown, D. Plowchalk, S. Vukicevic, and D. D. Thompson Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6736–6740. Published online 2003 May 14. doi: 10.1073/pnas.1037343100.PMCID: PMC164516 Asialoerythropoietin is a nonerythropoietic cytokine with broad neuroprotective activity in vivo Serhat Erbayraktar, Giovanni Grasso, Alessandra Sfacteria, Qiao-wen Xie, Thomas Coleman, Mads Kreilgaard, Lars Torup, Thomas Sager, Zubeyde Erbayraktar, Necati Gokmen, Osman Yilmaz, Pietro Ghezzi, Pia Villa, Maddalena Fratelli, Simona Casagrande, Marcel Leist, Lone Helboe, Jens Gerwein, Søren Christensen, Marie Aavang Geist, Lars Østergaard Pedersen, Carla Cerami-Hand, Jean-Paul Wuerth, Anthony Cerami, and Michael Brines Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6741–6746. Published online 2003 May 13. doi: 10.1073/pnas.1031753100.PMCID: PMC164517 T lymphoid differentiation in human bone marrow Florian Klein, Niklas Feldhahn, Sanggyu Lee, Hui Wang, Fiammetta Ciuffi, Mirko von Elstermann, María L. Toribio, Heinrich Sauer, Maria Wartenberg, Varun Singh Barath, Martin Krönke, Peter Wernet, Janet D. Rowley, and Markus Müschen Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6747–6752. Published online 2003 May 8. doi: 10.1073/pnas.1031503100.PMCID: PMC164518 Immunization with hepatitis C virus-like particles protects mice from recombinant hepatitis C virus-vaccinia infection Kazumoto Murata, Martin Lechmann, Ming Qiao, Toshiaki Gunji, Harvey J. Alter, and T. Jake Liang Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6753–6758. Published online 2003 May 14. doi: 10.1073/pnas.1131929100.PMCID: PMC164519 Microbiology Identification of receptors for pig endogenous retrovirus Thomas A. Ericsson, Yasuhiro Takeuchi, Christian Templin, Gary Quinn, Shelli F. Farhadian, James C. Wood, Beth A. Oldmixon, Kristen M. Suling, Jennifer K. Ishii, Yoshinori Kitagawa, Takayuki Miyazawa, Daniel R. Salomon, Robin A. Weiss, and Clive Patience Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6759–6764. Published online 2003 May 9. doi: 10.1073/pnas.1138025100.PMCID: PMC164520 Differential expression of growth factors at the cellular level in virus-infected brain Mikhail Prosniak, Anna Zborek, Gwen S. Scott, Anirban Roy, Timothy W. Phares, Hilary Koprowski, and D. Craig Hooper Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6765–6770. Published online 2003 May 7. doi: 10.1073/pnas.0430999100.PMCID: PMC164521 Golgi-dependent transport of cholesterol to the Chlamydia trachomatis inclusion Reynaldo A. Carabeo, David J. Mead, and Ted Hackstadt Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6771–6776. Published online 2003 May 12. doi: 10.1073/pnas.1131289100.PMCID: PMC164522 Neuroscience Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function Xinyu Zhao, Tetsuya Ueba, Brian R. Christie, Basam Barkho, Michael J. McConnell, Kinichi Nakashima, Edward S. Lein, Brennan D. Eadie, Andrew R. Willhoite, Alysson R. Muotri, Robert G. Summers, Jerold Chun, Kuo-Fen Lee, and Fred H. Gage Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6777–6782. Published online 2003 May 14. doi: 10.1073/pnas.1131928100.PMCID: PMC164523 Guanylate cyclase-activating protein (GCAP) 1 rescues cone recovery kinetics in GCAP1/GCAP2 knockout mice Mark E. Pennesi, Kim A. Howes, Wolfgang Baehr, and Samuel M. Wu Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6783–6788. Published online 2003 May 5. doi: 10.1073/pnas.1130102100.PMCID: PMC164524 d-serine and serine racemase are present in the vertebrate retina and contribute to the physiological activation of NMDA receptors Eric R. Stevens, Manuel Esguerra, Paul M. Kim, Eric A. Newman, Solomon H. Snyder, Kathleen R. Zahs, and Robert F. Miller Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6789–6794. Published online 2003 May 15. doi: 10.1073/pnas.1237052100.PMCID: PMC164525 Adrenergic regulation of clock gene expression in mouse liver Hideyuki Terazono, Tatsushi Mutoh, Shun Yamaguchi, Masaki Kobayashi, Masashi Akiyama, Rhyuta Udo, Shigehiro Ohdo, Hitoshi Okamura, and Shigenobu Shibata Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6795–6800. Published online 2003 May 16. doi: 10.1073/pnas.0936797100.PMCID: PMC164526 Calcium-permeable AMPA/kainate receptors mediate toxicity and preconditioning by oxygen-glucose deprivation in oligodendrocyte precursors Wenbin Deng, Paul A. Rosenberg, Joseph J. Volpe, and Frances E. Jensen Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6801–6806. Published online 2003 May 12. doi: 10.1073/pnas.1136624100.PMCID: PMC164527 Short- and long-term enhancement of excitatory transmission in the spinal cord dorsal horn by nicotinic acetylcholine receptors Jonathan R. Genzen and Daniel S. McGehee Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6807–6812. Published online 2003 May 14. doi: 10.1073/pnas.1131709100.PMCID: PMC164528 Pharmacology Alcohol potently inhibits the kainate receptor-dependent excitatory drive of hippocampal interneurons Mario Carta, Olusegun J. Ariwodola, Jeff L. Weiner, and C. Fernando Valenzuela Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6813–6818. Published online 2003 May 5. doi: 10.1073/pnas.1137276100.PMCID: PMC164529 Physiology Myocardial recovery from ischemia is impaired in CD36-null mice and restored by myocyte CD36 expression or medium-chain fatty acids Hiroshi Irie, Irvin B. Krukenkamp, Joep F. F. Brinkmann, Glenn R. Gaudette, Adam E. Saltman, William Jou, Jan F. C. Glatz, Nada A. Abumrad, and Azeddine Ibrahimi Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6819–6824. Published online 2003 May 13. doi: 10.1073/pnas.1132094100.PMCID: PMC164530 Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance Stacey L. Conarello, Zhihua Li, John Ronan, Ranabir Sinha Roy, Lan Zhu, Guoqiang Jiang, Franklin Liu, John Woods, Emanuel Zycband, David E. Moller, Nancy A. Thornberry, and Bei B. Zhang Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6825–6830. Published online 2003 May 14. doi: 10.1073/pnas.0631828100.PMCID: PMC164531 Plant Biology Antagonistic control of oxidative stress-induced cell death in Arabidopsis by two related, plant-specific zinc finger proteins Petra Epple, Amanda A. Mack, Veronica R. F. Morris, and Jeffery L. Dangl Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6831–6836. Published online 2003 May 5. doi: 10.1073/pnas.1130421100.PMCID: PMC164532 Conservation and molecular dissection of ROUGH SHEATH2 and ASYMMETRIC LEAVES1 function in leaf development George Theodoris, Noriko Inada, and Michael Freeling Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6837–6842. Published online 2003 May 15. doi: 10.1073/pnas.1132113100.PMCID: PMC164533 Mitochondrial succinic-semialdehyde dehydrogenase of the γ-aminobutyrate shunt is required to restrict levels of reactive oxygen intermediates in plants Nicolas Bouché, Aaron Fait, David Bouchez, Simon G. Møller, and Hillel Fromm Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6843–6848. Published online 2003 May 9. doi: 10.1073/pnas.1037532100.PMCID: PMC164534 Trehalose 6-phosphate is indispensable for carbohydrate utilization and growth in Arabidopsis thaliana Henriette Schluepmann, Till Pellny, Anja van Dijken, Sjef Smeekens, and Matthew Paul Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6849–6854. Published online 2003 May 14. doi: 10.1073/pnas.1132018100.PMCID: PMC164535 Control of seed germination in transgenic plants based on the segregation of a two-component genetic system Johann P. Schernthaner, Steven F. Fabijanski, Paul G. Arnison, Martine Racicot, and Laurian S. Robert Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6855–6859. Published online 2003 May 9. doi: 10.1073/pnas.1036833100.PMCID: PMC164536 The receptor kinases LePRK1 and LePRK2 associate in pollen and when expressed in yeast, but dissociate in the presence of style extract Diego Wengier, Isabel Valsecchi, María Laura Cabanas, Wei-hua Tang, Sheila McCormick, and Jorge Muschietti Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6860–6865. Published online 2003 May 14. doi: 10.1073/pnas.0631728100.PMCID: PMC164537 Crosstalk between cytosolic and plastidial pathways of isoprenoid biosynthesis in Arabidopsis thaliana Oliver Laule, Andreas Fürholz, Hur-Song Chang, Tong Zhu, Xun Wang, Peter B. Heifetz, Wilhelm Gruissem, and Markus Lange Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6866–6871. Published online 2003 May 14. doi: 10.1073/pnas.1031755100.PMCID: PMC164538 The putative glutamate receptor 1.1 (AtGLR1.1) functions as a regulator of carbon and nitrogen metabolism in Arabidopsis thaliana Jiman Kang and Frank J. Turano Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6872–6877. Published online 2003 May 8. doi: 10.1073/pnas.1030961100.PMCID: PMC164539 Two Arabidopsis circadian oscillators can be distinguished by differential temperature sensitivity Todd P. Michael, Patrice A. Salomé, and C. Robertson McClung Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6878–6883. Published online 2003 May 7. doi: 10.1073/pnas.1131995100.PMCID: PMC164540 Psychology Global perception in small brains: Topological pattern recognition in honey bees Lin Chen, Shaowu Zhang, and Mandyam V. Srinivasan Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6884–6889. Published online 2003 May 15. doi: 10.1073/pnas.0732090100.PMCID: PMC164541 Corrections Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6890. doi: 10.1073/pnas.1231735100.PMCID: PMC164542 Corrects: Hoon Ryu, et al. Histone deacetylase inhibitors prevent oxidative neuronal death independent of expanded polyglutamine repeats via an Sp1-dependent pathway. Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4281–4286. Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6890. Published online 2003 May 9. doi: 10.1073/pnas.1232296100.PMCID: PMC164543 Corrects: Elizabeth A. Kellogg. What happens to genes in duplicated genomes. Proc Natl Acad Sci U S A. 2003 April 15; 100(8): 4369–4371. Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6890. Published online 2003 May 2. doi: 10.1073/pnas.1131491100.PMCID: PMC164544 Corrects: Muhammad Al-Hajj, et al. From the Cover: Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3983–3988. Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6890. doi: 10.1073/pnas.1232295100.PMCID: PMC164545 Corrects: Lian Fan, et al. Antigen presentation by keratinocytes directs autoimmune skin disease. Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3386–3391. Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6891. Published online 2003 May 15. doi: 10.1073/pnas.1232068100.PMCID: PMC164546 Corrects: Hiroshi Miyamoto, et al. 3β-Acetoxyandrost-1,5-diene-17-ethylene ketal functions as a potent antiandrogen with marginal agonist activity. Proc Natl Acad Sci U S A. 2003 April 15; 100(8): 4440–4444. |