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Volume 100(11);  May 27, 2003
Commentaries
The specifics of small interfering RNA specificity
Andrew Dillin
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6289–6291. Published online 2003 May 16. doi: 10.1073/pnas.1232238100.
PMCID: PMC164437
A fratricidal fungal prion
David D. Perkins
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6292–6294. Published online 2003 May 16. doi: 10.1073/pnas.1332353100.
PMCID: PMC164438
Suppression of macrophage inflammatory responses by PPARs
Peter Henson
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6295–6296. Published online 2003 May 19. doi: 10.1073/pnas.1232410100.
PMCID: PMC164439
Physical Sciences
Applied Physical Sciences
Beyond superquenching: Hyper-efficient energy transfer from conjugated polymers to gold nanoparticles
Chunhai Fan, Shu Wang, Janice W. Hong, Guillermo C. Bazan, Kevin W. Plaxco, and Alan J. Heeger
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6297–6301. Published online 2003 May 15. doi: 10.1073/pnas.1132025100.
PMCID: PMC164440
Chemistry
Interaction of antimicrobial peptide protegrin with biomembranes
David Gidalevitz, Yuji Ishitsuka, Adrian S. Muresan, Oleg Konovalov, Alan J. Waring, Robert I. Lehrer, and Ka Yee C. Lee
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6302–6307. Published online 2003 May 8. doi: 10.1073/pnas.0934731100.
PMCID: PMC164441
Engineering
Retrofitting existing chemical scrubbers to biotrickling filters for H2S emission control
David Gabriel and Marc A. Deshusses
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6308–6312. Published online 2003 May 9. doi: 10.1073/pnas.0731894100.
PMCID: PMC164442
Mathematics
Spectra of random graphs with given expected degrees
Fan Chung, Linyuan Lu, and Van Vu
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6313–6318. Published online 2003 May 12. doi: 10.1073/pnas.0937490100.
PMCID: PMC164443
Biological Sciences
Applied Biological Sciences
Global atmospheric black carbon inferred from AERONET
Makiko Sato, James Hansen, Dorothy Koch, Andrew Lacis, Reto Ruedy, Oleg Dubovik, Brent Holben, Mian Chin, and Tica Novakov
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6319–6324. Published online 2003 May 13. doi: 10.1073/pnas.0731897100.
PMCID: PMC164444
Spontaneous mitotic homologous recombination at an enhanced yellow fluorescent protein (EYFP) cDNA direct repeat in transgenic mice
Carrie A. Hendricks, Karen H. Almeida, Molly S. Stitt, Vidya S. Jonnalagadda, Rebecca E. Rugo, G. Foster Kerrison, and Bevin P. Engelward
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6325–6330. Published online 2003 May 15. doi: 10.1073/pnas.1232231100.
PMCID: PMC164445
Interaction of soft condensed materials with living cells: Phenotype/transcriptome correlations for the hydrophobic effect
Lorcan T. Allen, Edward J. P. Fox, Irena Blute, Zoe D. Kelly, Yuri Rochev, Alan K. Keenan, Kenneth A. Dawson, and William M. Gallagher
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6331–6336. Published online 2003 May 13. doi: 10.1073/pnas.1031426100.
PMCID: PMC164446
Biochemistry
ATP hydrolysis on actin-related protein 2/3 complex causes debranching of dendritic actin arrays
Christophe Le Clainche, Dominique Pantaloni, and Marie-France Carlier
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6337–6342. Published online 2003 May 12. doi: 10.1073/pnas.1130513100.
PMCID: PMC164447
From the Cover:
Genomewide view of gene silencing by small interfering RNAs
Jen-Tsan Chi, Howard Y. Chang, Nancy N. Wang, Dustin S. Chang, Nina Dunphy, and Patrick O. Brown
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6343–6346. Published online 2003 May 2. doi: 10.1073/pnas.1037853100.
PMCID: PMC164448
From the Cover:
Specificity of short interfering RNA determined through gene expression signatures
Dimitri Semizarov, Leigh Frost, Aparna Sarthy, Paul Kroeger, Donald N. Halbert, and Stephen W. Fesik
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6347–6352. Published online 2003 May 13. doi: 10.1073/pnas.1131959100.
PMCID: PMC164449
Programming peptidomimetic syntheses by translating genetic codes designed de novo
Anthony C. Forster, Zhongping Tan, Madhavi N. L. Nalam, Hening Lin, Hui Qu, Virginia W. Cornish, and Stephen C. Blacklow
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6353–6357. Published online 2003 May 16. doi: 10.1073/pnas.1132122100.
PMCID: PMC164450
Fatty acid synthesis is essential in embryonic development: Fatty acid synthase null mutants and most of the heterozygotes die in utero
Subrahmanyam S. Chirala, Hua Chang, Martin Matzuk, Lutfi Abu-Elheiga, Jianqiang Mao, Kathleen Mahon, Milton Finegold, and Salih J. Wakil
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6358–6363. Published online 2003 May 8. doi: 10.1073/pnas.0931394100.
PMCID: PMC164451
Genomewide demarcation of RNA polymerase II transcription units revealed by physical fractionation of chromatin
Peter L. Nagy, Michael L. Cleary, Patrick O. Brown, and Jason D. Lieb
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6364–6369. Published online 2003 May 15. doi: 10.1073/pnas.1131966100.
PMCID: PMC164452
Spherical aggregates of β-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3β
Minako Hoshi, Michio Sato, Shinichiro Matsumoto, Akihiko Noguchi, Kaori Yasutake, Natsuko Yoshida, and Kazuki Sato
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6370–6375. Published online 2003 May 15. doi: 10.1073/pnas.1237107100.
PMCID: PMC164453
Structural and biochemical studies of p21Ras S-nitrosylation and nitric oxide-mediated guanine nucleotide exchange
Jason G. Williams, Kamesh Pappu, and Sharon L. Campbell
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6376–6381. Published online 2003 May 9. doi: 10.1073/pnas.1037299100.
PMCID: PMC164454
γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2
W. Taylor Kimberly, Matthew J. LaVoie, Beth L. Ostaszewski, Wenjuan Ye, Michael S. Wolfe, and Dennis J. Selkoe
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6382–6387. Published online 2003 May 9. doi: 10.1073/pnas.1037392100.
PMCID: PMC164455
Quality control of ribosomal RNA mediated by polynucleotide phosphorylase and RNase R
Zhuan-Fen Cheng and Murray P. Deutscher
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6388–6393. Published online 2003 May 12. doi: 10.1073/pnas.1231041100.
PMCID: PMC164456
Understanding tubulin–Taxol interactions: Mutations that impart Taxol binding to yeast tubulin
Mohan L. Gupta, Jr., Claudia J. Bode, Gunda I. Georg, and Richard H. Himes
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6394–6397. Published online 2003 May 9. doi: 10.1073/pnas.1131967100.
PMCID: PMC164457
Vam10p defines a Sec18p-independent step of priming that allows yeast vacuole tethering
Masashi Kato and William Wickner
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6398–6403. Published online 2003 May 14. doi: 10.1073/pnas.1132162100.
PMCID: PMC164458
Molecular genetic analysis of the glycosyltransferase Fringe in Drosophila
Trudy Correia, Venizelos Papayannopoulos, Vladislav Panin, Pamela Woronoff, Jin Jiang, Thomas F. Vogt, and Kenneth D. Irvine
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6404–6409. Published online 2003 May 12. doi: 10.1073/pnas.1131007100.
PMCID: PMC164459
How the BfiI restriction enzyme uses one active site to cut two DNA strands
Giedrius Sasnauskas, Stephen E. Halford, and Virginijus Siksnys
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6410–6415. Published online 2003 May 15. doi: 10.1073/pnas.1131003100.
PMCID: PMC164460
Exponential growth by cross-catalytic cleavage of deoxyribozymogens
Matthew Levy and Andrew D. Ellington
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6416–6421. Published online 2003 May 12. doi: 10.1073/pnas.1130145100.
PMCID: PMC164461
TRAP230/ARC240 and TRAP240/ARC250 Mediator subunits are functionally conserved through evolution
Camilla O. Samuelsen, Vera Baraznenok, Olga Khorosjutina, Henrik Spåhr, Thomas Kieselbach, Steen Holmberg, and Claes M. Gustafsson
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6422–6427. Published online 2003 May 8. doi: 10.1073/pnas.1030497100.
PMCID: PMC164462
Chloride, not sodium, stimulates expression of the γ subunit of Na/K-ATPase and activates JNK in response to hypertonicity in mouse IMCD3 cells
Juan M. Capasso, Christopher J. Rivard, Laura M. Enomoto, and Tomas Berl
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6428–6433. Published online 2003 May 13. doi: 10.1073/pnas.1130871100.
PMCID: PMC164463
Biophysics
The working stroke upon myosin–nucleotide complexes binding to actin
Walter Steffen, David Smith, and John Sleep
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6434–6439. Published online 2003 May 15. doi: 10.1073/pnas.1231998100.
PMCID: PMC164464
Structural basis of albumin–thyroxine interactions and familial dysalbuminemic hyperthyroxinemia
Isabelle Petitpas, Charles E. Petersen, Chung-Eun Ha, Ananyo A. Bhattacharya, Patricia A. Zunszain, Jamie Ghuman, Nadhipuram V. Bhagavan, and Stephen Curry
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6440–6445. Published online 2003 May 12. doi: 10.1073/pnas.1137188100.
PMCID: PMC164465
Structural defects and the diagnosis of amyloidogenic propensity
Ariel Fernández, József Kardos, L. Ridgway Scott, Yuji Goto, and R. Stephen Berry
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6446–6451. Published online 2003 May 12. doi: 10.1073/pnas.0731893100.
PMCID: PMC164466
Picosecond conformational transition and equilibration of a cyclic peptide
Jens Bredenbeck, Jan Helbing, Arne Sieg, Tobias Schrader, Wolfgang Zinth, Christian Renner, Raymond Behrendt, Luis Moroder, Josef Wachtveitl, and Peter Hamm
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6452–6457. Published online 2003 May 7. doi: 10.1073/pnas.1036583100.
PMCID: PMC164467
Structure of the coat protein in fd filamentous bacteriophage particles determined by solid-state NMR spectroscopy
Ana Carolina Zeri, Michael F. Mesleh, Alexander A. Nevzorov, and Stanley J. Opella
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6458–6463. Published online 2003 May 15. doi: 10.1073/pnas.1132059100.
PMCID: PMC164468
Cell Biology
Specific protein methylation defects and gene expression perturbations in coactivator-associated arginine methyltransferase 1-deficient mice
Neelu Yadav, Jaeho Lee, Jeesun Kim, Jianjun Shen, Mickey C.-T. Hu, C. Marcelo Aldaz, and Mark T. Bedford
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6464–6468. Published online 2003 May 19. doi: 10.1073/pnas.1232272100.
PMCID: PMC164469
Exo1: A new chemical inhibitor of the exocytic pathway
Yan Feng, Sidney Yu, Troy K. R. Lasell, Ashutosh P. Jadhav, Eric Macia, Pierre Chardin, Paul Melancon, Michael Roth, Timothy Mitchison, and Tomas Kirchhausen
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6469–6474. Published online 2003 May 8. doi: 10.1073/pnas.0631766100.
PMCID: PMC164470
An actin–ribonucleoprotein interaction is involved in transcription by RNA polymerase II
Piergiorgio Percipalle, Nathalie Fomproix, Karin Kylberg, Francesc Miralles, Birgitta Björkroth, Bertil Daneholt, and Neus Visa
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6475–6480. Published online 2003 May 12. doi: 10.1073/pnas.1131933100.
PMCID: PMC164471
Abnormal phagocytosis by retinal pigmented epithelium that lacks myosin VIIa, the Usher syndrome 1B protein
Daniel Gibbs, Junko Kitamoto, and David S. Williams
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6481–6486. Published online 2003 May 12. doi: 10.1073/pnas.1130432100.
PMCID: PMC164472
Spermatogonial stem cells share some, but not all, phenotypic and functional characteristics with other stem cells
Hiroshi Kubota, Mary R. Avarbock, and Ralph L. Brinster
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6487–6492. Published online 2003 May 8. doi: 10.1073/pnas.0631767100.
PMCID: PMC164473
Compression forces generated by actin comet tails on lipid vesicles
Paula A. Giardini, Daniel A. Fletcher, and Julie A. Theriot
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6493–6498. Published online 2003 May 8. doi: 10.1073/pnas.1031670100.
PMCID: PMC164474
Dictyostelium and Acanthamoeba myosin II assembly domains go to the cleavage furrow of Dictyostelium myosin II-null cells
Shi Shu, Xiong Liu, and Edward D. Korn
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6499–6504. Published online 2003 May 14. doi: 10.1073/pnas.0732155100.
PMCID: PMC164475
Epidermal growth factor receptor signaling intensity determines intracellular protein interactions, ubiquitination, and internalization
Mirko H. H. Schmidt, Frank B. Furnari, Webster K. Cavenee, and Oliver Bögler
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6505–6510. Published online 2003 May 6. doi: 10.1073/pnas.1031790100.
PMCID: PMC164476
The phosphorylation of caveolin-2 on serines 23 and 36 modulates caveolin-1-dependent caveolae formation
Grzegorz Sowa, Marc Pypaert, David Fulton, and William C. Sessa
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6511–6516. Published online 2003 May 12. doi: 10.1073/pnas.1031672100.
PMCID: PMC164477
The basic helix–loop–helix–PAS protein ARNT functions as a potent coactivator of estrogen receptor-dependent transcription
Sara Brunnberg, Katarina Pettersson, Elin Rydin, Jason Matthews, Annika Hanberg, and Ingemar Pongratz
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6517–6522. Published online 2003 May 16. doi: 10.1073/pnas.1136688100.
PMCID: PMC164478
Cytokines and BCR-ABL mediate suppression of TRAIL-induced apoptosis through inhibition of forkhead FOXO3a transcription factor
Saghi Ghaffari, Zainab Jagani, Claire Kitidis, Harvey F. Lodish, and Roya Khosravi-Far
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6523–6528. Published online 2003 May 15. doi: 10.1073/pnas.0731871100.
PMCID: PMC164479
Targeting Ras signaling through inhibition of carboxyl methylation: An unexpected property of methotrexate
Ann M. Winter-Vann, Barton A. Kamen, Martin O. Bergo, Stephen G. Young, Stepan Melnyk, S. Jill James, and Patrick J. Casey
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6529–6534. Published online 2003 May 15. doi: 10.1073/pnas.1135239100.
PMCID: PMC164480
Developmental Biology
Positional cloning of the young mutation identifies an essential role for the Brahma chromatin remodeling complex in mediating retinal cell differentiation
Ronald G. Gregg, Gregory B. Willer, James M. Fadool, John E. Dowling, and Brian A. Link
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6535–6540. Published online 2003 May 14. doi: 10.1073/pnas.0631813100.
PMCID: PMC164481
Development of teeth in chick embryos after mouse neural crest transplantations
Thimios A. Mitsiadis, Yvonnick Chéraud, Paul Sharpe, and Josiane Fontaine-Pérus
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6541–6545. Published online 2003 May 9. doi: 10.1073/pnas.1137104100.
PMCID: PMC164482
Rb function in extraembryonic lineages suppresses apoptosis in the CNS of Rb-deficient mice
Alain de Bruin, Lizhao Wu, Harold I. Saavedra, Pamela Wilson, Ying Yang, Thomas J. Rosol, Michael Weinstein, Michael L. Robinson, and Gustavo Leone
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6546–6551. Published online 2003 May 5. doi: 10.1073/pnas.1031853100.
PMCID: PMC164483
sal1 determines the number of aleurone cell layers in maize endosperm and encodes a class E vacuolar sorting protein
Bo Shen, Changjiang Li, Zhao Min, Robert B. Meeley, Mitchell C. Tarczynski, and Odd-Arne Olsen
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6552–6557. Published online 2003 May 15. doi: 10.1073/pnas.0732023100.
PMCID: PMC164484
Functional divergence within the APETALA3/PISTILLATA floral homeotic gene lineages
Rebecca S. Lamb and Vivian F. Irish
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6558–6563. Published online 2003 May 13. doi: 10.1073/pnas.0631708100.
PMCID: PMC164485
Ecology
Biocomplexity and fisheries sustainability
Ray Hilborn, Thomas P. Quinn, Daniel E. Schindler, and Donald E. Rogers
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6564–6568. Published online 2003 May 12. doi: 10.1073/pnas.1037274100.
PMCID: PMC164486
Evolution
Molecular paleontology of transposable elements in the Drosophila melanogaster genome
Vladimir V. Kapitonov and Jerzy Jurka
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6569–6574. Published online 2003 May 12. doi: 10.1073/pnas.0732024100.
PMCID: PMC164487
Evolution of the army ant syndrome: The origin and long-term evolutionary stasis of a complex of behavioral and reproductive adaptations
Seán G. Brady
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6575–6579. Published online 2003 May 15. doi: 10.1073/pnas.1137809100.
PMCID: PMC164488
A new Drosophila spliceosomal intron position is common in plants
Rosa Tarrío, Francisco Rodríguez-Trelles, and Francisco J. Ayala
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6580–6583. Published online 2003 May 15. doi: 10.1073/pnas.0731952100.
PMCID: PMC164489
Mate choice theory and the mode of selection in sexual populations
Hampton L. Carson
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6584–6587. Published online 2003 May 12. doi: 10.1073/pnas.0732174100.
PMCID: PMC164490
Tracing the origin and history of the HIV-2 epidemic
Philippe Lemey, Oliver G. Pybus, Bin Wang, Nitin K. Saksena, Marco Salemi, and Anne-Mieke Vandamme
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6588–6592. Published online 2003 May 12. doi: 10.1073/pnas.0936469100.
PMCID: PMC164491
From the Cover:
Evidence for a genetic discontinuity between Neandertals and 24,000-year-old anatomically modern Europeans
David Caramelli, Carles Lalueza-Fox, Cristiano Vernesi, Martina Lari, Antonella Casoli, Francesco Mallegni, Brunetto Chiarelli, Isabelle Dupanloup, Jaume Bertranpetit, Guido Barbujani, and Giorgio Bertorelle
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6593–6597. Published online 2003 May 12. doi: 10.1073/pnas.1130343100.
PMCID: PMC164492
Sympatric speciation as a consequence of male pregnancy in seahorses
Adam G. Jones, Glenn I. Moore, Charlotta Kvarnemo, DeEtte Walker, and John C. Avise
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6598–6603. Published online 2003 May 5. doi: 10.1073/pnas.1131969100.
PMCID: PMC164493
Genetics
Instability of GGL domain-containing RGS proteins in mice lacking the G protein β-subunit Gβ5
Ching-Kang Chen, Pamela Eversole-Cire, Haikun Zhang, Valeria Mancino, Yu-Jiun Chen, Wei He, Theodore G. Wensel, and Melvin I. Simon
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6604–6609. Published online 2003 May 8. doi: 10.1073/pnas.0631825100.
PMCID: PMC164494
Susceptibility to tuberculosis: A locus on mouse chromosome 19 (Trl-4) regulates Mycobacterium tuberculosis replication in the lungs
Loukia-Maria Mitsos, Lon R. Cardon, Lynn Ryan, Ronald LaCourse, Robert J. North, and Philippe Gros
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6610–6615. Published online 2003 May 9. doi: 10.1073/pnas.1031727100.
PMCID: PMC164495
From the Cover:
Sexual transmission of the [Het-s] prion leads to meiotic drive in Podospora anserina
Henk J. P. Dalstra, Klaas Swart, Alfons J. M. Debets, Sven J. Saupe, and Rolf F. Hoekstra
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6616–6621. Published online 2003 April 28. doi: 10.1073/pnas.1030058100.
PMCID: PMC164496
Coincidence of synteny breakpoints with malignancy-related deletions on human chromosome 3
Maria Kost-Alimova, Hajnalka Kiss, Ludmila Fedorova, Ying Yang, Jan P. Dumanski, George Klein, and Stefan Imreh
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6622–6627. Published online 2003 May 8. doi: 10.1073/pnas.0430971100.
PMCID: PMC164497
Subcellular localization of yeast ribonucleotide reductase regulated by the DNA replication and damage checkpoint pathways
Ruojin Yao, Zhen Zhang, Xiuxiang An, Brigid Bucci, Deborah L. Perlstein, JoAnne Stubbe, and Mingxia Huang
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6628–6633. Published online 2003 May 5. doi: 10.1073/pnas.1131932100.
PMCID: PMC164498
Purine synthesis and increased Agrobacterium tumefaciens transformation of yeast and plants
Radclyffe L. Roberts, Matthew Metz, Dave E. Monks, Matthew Lockwood Mullaney, Tyler Hall, and Eugene W. Nester
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6634–6639. Published online 2003 May 9. doi: 10.1073/pnas.1132022100.
PMCID: PMC164499
Saccharomyces cerevisiae chromatin-assembly factors that act during DNA replication function in the maintenance of genome stability
Kyungjae Myung, Vincent Pennaneach, Ellen S. Kats, and Richard D. Kolodner
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6640–6645. Published online 2003 May 15. doi: 10.1073/pnas.1232239100.
PMCID: PMC164500
Immunology
Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: Activation of Toll-like receptor 7
Jongdae Lee, Tsung-Hsien Chuang, Vanessa Redecke, Liping She, Paula M. Pitha, Dennis A. Carson, Eyal Raz, and Howard B. Cottam
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6646–6651. Published online 2003 May 8. doi: 10.1073/pnas.0631696100.
PMCID: PMC164501
A fragment of anthrax lethal factor delivers proteins to the cytosol without requiring protective antigen
Nicholas Kushner, Dong Zhang, Neal Touzjian, Max Essex, Judy Lieberman, and Yichen Lu
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6652–6657. Published online 2003 May 9. doi: 10.1073/pnas.1131930100.
PMCID: PMC164502
T helper type 1 lymphocytes drive inflammation in human atherosclerotic lesions
Marisa Benagiano, Annalisa Azzurri, Alessandra Ciervo, Amedeo Amedei, Carlo Tamburini, Mauro Ferrari, John L. Telford, Cosima T. Baldari, Sergio Romagnani, Antonio Cassone, Mario M. D'Elios, and Gianfranco Del Prete
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6658–6663. Published online 2003 May 9. doi: 10.1073/pnas.1135726100.
PMCID: PMC164503
Human cathepsin S, but not cathepsin L, degrades efficiently MHC class II-associated invariant chain in nonprofessional APCs
Jacek Bania, Evelina Gatti, Hugues Lelouard, Alexandre David, Fanny Cappello, Ekkehard Weber, Voahirana Camosseto, and Philippe Pierre
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6664–6669. Published online 2003 May 14. doi: 10.1073/pnas.1131604100.
PMCID: PMC164504
Direct stimulation of naïve T cells by membrane vesicles from antigen-presenting cells: Distinct roles for CD54 and B7 molecules
Inkyu Hwang, Xuefei Shen, and Jonathan Sprent
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6670–6675. Published online 2003 May 12. doi: 10.1073/pnas.1131852100.
PMCID: PMC164505
A dual altered peptide ligand down-regulates myasthenogenic T cell responses by up-regulating CD25- and CTLA-4-expressing CD4+ T cells
Miri Paas-Rozner, Michael Sela, and Edna Mozes
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6676–6681. Published online 2003 May 12. doi: 10.1073/pnas.1131898100.
PMCID: PMC164506
Spontaneous regression of advanced cancer: Identification of a unique genetically determined, age-dependent trait in mice
Zheng Cui, Mark C. Willingham, Amy M. Hicks, Martha A. Alexander-Miller, Timothy D. Howard, Gregory A. Hawkins, Mark S. Miller, Holly M. Weir, Wei Du, and Cynthia J. DeLong
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6682–6687. Published online 2003 April 30. doi: 10.1073/pnas.1031601100.
PMCID: PMC164507
Beta cell MHC class I is a late requirement for diabetes
Emma E. Hamilton-Williams, Stephanie E. Palmer, Brett Charlton, and Robyn M. Slattery
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6688–6693. Published online 2003 May 15. doi: 10.1073/pnas.1131954100.
PMCID: PMC164508
Medical Sciences
Disruption of the estrogen receptor β gene in mice causes myeloproliferative disease resembling chronic myeloid leukemia with lymphoid blast crisis
Gil-Jin Shim, Ling Wang, Sandra Andersson, Noémi Nagy, Loránd Levente Kis, Qinghong Zhang, Sari Mäkelä, Margaret Warner, and Jan-Åke Gustafsson
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6694–6699. Published online 2003 May 9. doi: 10.1073/pnas.0731830100.
PMCID: PMC164509
Copper chelation represses the vascular response to injury
Lazar Mandinov, Anna Mandinova, Stanimir Kyurkchiev, Dobroslav Kyurkchiev, Ivan Kehayov, Vihren Kolev, Raffaella Soldi, Cinzia Bagala, Ebo D. de Muinck, Volkhard Lindner, Mark J. Post, Michael Simons, Stephen Bellum, Igor Prudovsky, and Thomas Maciag
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6700–6705. Published online 2003 May 16. doi: 10.1073/pnas.1231994100.
PMCID: PMC164510
Gastrointestinal stromal tumors in a mouse model by targeted mutation of the Kit receptor tyrosine kinase
Gunhild Sommer, Valter Agosti, Imke Ehlers, Ferdinand Rossi, Selim Corbacioglu, Judith Farkas, Malcolm Moore, Katia Manova, Cristina R. Antonescu, and Peter Besmer
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6706–6711. Published online 2003 May 16. doi: 10.1073/pnas.1037763100.
PMCID: PMC164511
From the Cover:
PPARγ and PPARδ negatively regulate specific subsets of lipopolysaccharide and IFN-γ target genes in macrophages
John S. Welch, Mercedes Ricote, Taro E. Akiyama, Frank J. Gonzalez, and Christopher K. Glass
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6712–6717. Published online 2003 May 9. doi: 10.1073/pnas.1031789100.
PMCID: PMC164512
Inhibition of p53-induced apoptosis without affecting expression of p53-regulated genes
Joseph Lotem, Hilah Gal, Rachel Kama, Ninette Amariglio, Gideon Rechavi, Eytan Domany, Leo Sachs, and David Givol
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6718–6723. Published online 2003 May 12. doi: 10.1073/pnas.1031695100.
PMCID: PMC164513
Adoptive transfer of apoptotic splenocytes worsens survival, whereas adoptive transfer of necrotic splenocytes improves survival in sepsis
Richard S. Hotchkiss, Katherine C. Chang, Mitchell H. Grayson, Kevin W. Tinsley, Benjamin S. Dunne, Christopher G. Davis, Dale F. Osborne, and Irene E. Karl
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6724–6729. Published online 2003 May 7. doi: 10.1073/pnas.1031788100.
PMCID: PMC164514
β3 integrin deficiency promotes atherosclerosis and pulmonary inflammation in high-fat-fed, hyperlipidemic mice
Sherry Weng, Laura Zemany, Kara N. Standley, Deborah V. Novack, Marie La Regina, Carlos Bernal-Mizrachi, Trey Coleman, and Clay F. Semenkovich
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6730–6735. Published online 2003 May 13. doi: 10.1073/pnas.1137612100.
PMCID: PMC164515
An EP2 receptor-selective prostaglandin E2 agonist induces bone healing
V. M. Paralkar, F. Borovecki, H. Z. Ke, K. O. Cameron, B. Lefker, W. A. Grasser, T. A. Owen, M. Li, P. DaSilva-Jardine, M. Zhou, R. L. Dunn, F. Dumont, R. Korsmeyer, P. Krasney, T. A. Brown, D. Plowchalk, S. Vukicevic, and D. D. Thompson
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6736–6740. Published online 2003 May 14. doi: 10.1073/pnas.1037343100.
PMCID: PMC164516
Asialoerythropoietin is a nonerythropoietic cytokine with broad neuroprotective activity in vivo
Serhat Erbayraktar, Giovanni Grasso, Alessandra Sfacteria, Qiao-wen Xie, Thomas Coleman, Mads Kreilgaard, Lars Torup, Thomas Sager, Zubeyde Erbayraktar, Necati Gokmen, Osman Yilmaz, Pietro Ghezzi, Pia Villa, Maddalena Fratelli, Simona Casagrande, Marcel Leist, Lone Helboe, Jens Gerwein, Søren Christensen, Marie Aavang Geist, Lars Østergaard Pedersen, Carla Cerami-Hand, Jean-Paul Wuerth, Anthony Cerami, and Michael Brines
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6741–6746. Published online 2003 May 13. doi: 10.1073/pnas.1031753100.
PMCID: PMC164517
T lymphoid differentiation in human bone marrow
Florian Klein, Niklas Feldhahn, Sanggyu Lee, Hui Wang, Fiammetta Ciuffi, Mirko von Elstermann, María L. Toribio, Heinrich Sauer, Maria Wartenberg, Varun Singh Barath, Martin Krönke, Peter Wernet, Janet D. Rowley, and Markus Müschen
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6747–6752. Published online 2003 May 8. doi: 10.1073/pnas.1031503100.
PMCID: PMC164518
Immunization with hepatitis C virus-like particles protects mice from recombinant hepatitis C virus-vaccinia infection
Kazumoto Murata, Martin Lechmann, Ming Qiao, Toshiaki Gunji, Harvey J. Alter, and T. Jake Liang
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6753–6758. Published online 2003 May 14. doi: 10.1073/pnas.1131929100.
PMCID: PMC164519
Microbiology
Identification of receptors for pig endogenous retrovirus
Thomas A. Ericsson, Yasuhiro Takeuchi, Christian Templin, Gary Quinn, Shelli F. Farhadian, James C. Wood, Beth A. Oldmixon, Kristen M. Suling, Jennifer K. Ishii, Yoshinori Kitagawa, Takayuki Miyazawa, Daniel R. Salomon, Robin A. Weiss, and Clive Patience
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6759–6764. Published online 2003 May 9. doi: 10.1073/pnas.1138025100.
PMCID: PMC164520
Differential expression of growth factors at the cellular level in virus-infected brain
Mikhail Prosniak, Anna Zborek, Gwen S. Scott, Anirban Roy, Timothy W. Phares, Hilary Koprowski, and D. Craig Hooper
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6765–6770. Published online 2003 May 7. doi: 10.1073/pnas.0430999100.
PMCID: PMC164521
Golgi-dependent transport of cholesterol to the Chlamydia trachomatis inclusion
Reynaldo A. Carabeo, David J. Mead, and Ted Hackstadt
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6771–6776. Published online 2003 May 12. doi: 10.1073/pnas.1131289100.
PMCID: PMC164522
Neuroscience
Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function
Xinyu Zhao, Tetsuya Ueba, Brian R. Christie, Basam Barkho, Michael J. McConnell, Kinichi Nakashima, Edward S. Lein, Brennan D. Eadie, Andrew R. Willhoite, Alysson R. Muotri, Robert G. Summers, Jerold Chun, Kuo-Fen Lee, and Fred H. Gage
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6777–6782. Published online 2003 May 14. doi: 10.1073/pnas.1131928100.
PMCID: PMC164523
Guanylate cyclase-activating protein (GCAP) 1 rescues cone recovery kinetics in GCAP1/GCAP2 knockout mice
Mark E. Pennesi, Kim A. Howes, Wolfgang Baehr, and Samuel M. Wu
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6783–6788. Published online 2003 May 5. doi: 10.1073/pnas.1130102100.
PMCID: PMC164524
d-serine and serine racemase are present in the vertebrate retina and contribute to the physiological activation of NMDA receptors
Eric R. Stevens, Manuel Esguerra, Paul M. Kim, Eric A. Newman, Solomon H. Snyder, Kathleen R. Zahs, and Robert F. Miller
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6789–6794. Published online 2003 May 15. doi: 10.1073/pnas.1237052100.
PMCID: PMC164525
Adrenergic regulation of clock gene expression in mouse liver
Hideyuki Terazono, Tatsushi Mutoh, Shun Yamaguchi, Masaki Kobayashi, Masashi Akiyama, Rhyuta Udo, Shigehiro Ohdo, Hitoshi Okamura, and Shigenobu Shibata
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6795–6800. Published online 2003 May 16. doi: 10.1073/pnas.0936797100.
PMCID: PMC164526
Calcium-permeable AMPA/kainate receptors mediate toxicity and preconditioning by oxygen-glucose deprivation in oligodendrocyte precursors
Wenbin Deng, Paul A. Rosenberg, Joseph J. Volpe, and Frances E. Jensen
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6801–6806. Published online 2003 May 12. doi: 10.1073/pnas.1136624100.
PMCID: PMC164527
Short- and long-term enhancement of excitatory transmission in the spinal cord dorsal horn by nicotinic acetylcholine receptors
Jonathan R. Genzen and Daniel S. McGehee
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6807–6812. Published online 2003 May 14. doi: 10.1073/pnas.1131709100.
PMCID: PMC164528
Pharmacology
Alcohol potently inhibits the kainate receptor-dependent excitatory drive of hippocampal interneurons
Mario Carta, Olusegun J. Ariwodola, Jeff L. Weiner, and C. Fernando Valenzuela
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6813–6818. Published online 2003 May 5. doi: 10.1073/pnas.1137276100.
PMCID: PMC164529
Physiology
Myocardial recovery from ischemia is impaired in CD36-null mice and restored by myocyte CD36 expression or medium-chain fatty acids
Hiroshi Irie, Irvin B. Krukenkamp, Joep F. F. Brinkmann, Glenn R. Gaudette, Adam E. Saltman, William Jou, Jan F. C. Glatz, Nada A. Abumrad, and Azeddine Ibrahimi
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6819–6824. Published online 2003 May 13. doi: 10.1073/pnas.1132094100.
PMCID: PMC164530
Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance
Stacey L. Conarello, Zhihua Li, John Ronan, Ranabir Sinha Roy, Lan Zhu, Guoqiang Jiang, Franklin Liu, John Woods, Emanuel Zycband, David E. Moller, Nancy A. Thornberry, and Bei B. Zhang
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6825–6830. Published online 2003 May 14. doi: 10.1073/pnas.0631828100.
PMCID: PMC164531
Plant Biology
Antagonistic control of oxidative stress-induced cell death in Arabidopsis by two related, plant-specific zinc finger proteins
Petra Epple, Amanda A. Mack, Veronica R. F. Morris, and Jeffery L. Dangl
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6831–6836. Published online 2003 May 5. doi: 10.1073/pnas.1130421100.
PMCID: PMC164532
Conservation and molecular dissection of ROUGH SHEATH2 and ASYMMETRIC LEAVES1 function in leaf development
George Theodoris, Noriko Inada, and Michael Freeling
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6837–6842. Published online 2003 May 15. doi: 10.1073/pnas.1132113100.
PMCID: PMC164533
Mitochondrial succinic-semialdehyde dehydrogenase of the γ-aminobutyrate shunt is required to restrict levels of reactive oxygen intermediates in plants
Nicolas Bouché, Aaron Fait, David Bouchez, Simon G. Møller, and Hillel Fromm
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6843–6848. Published online 2003 May 9. doi: 10.1073/pnas.1037532100.
PMCID: PMC164534
Trehalose 6-phosphate is indispensable for carbohydrate utilization and growth in Arabidopsis thaliana
Henriette Schluepmann, Till Pellny, Anja van Dijken, Sjef Smeekens, and Matthew Paul
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6849–6854. Published online 2003 May 14. doi: 10.1073/pnas.1132018100.
PMCID: PMC164535
Control of seed germination in transgenic plants based on the segregation of a two-component genetic system
Johann P. Schernthaner, Steven F. Fabijanski, Paul G. Arnison, Martine Racicot, and Laurian S. Robert
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6855–6859. Published online 2003 May 9. doi: 10.1073/pnas.1036833100.
PMCID: PMC164536
The receptor kinases LePRK1 and LePRK2 associate in pollen and when expressed in yeast, but dissociate in the presence of style extract
Diego Wengier, Isabel Valsecchi, María Laura Cabanas, Wei-hua Tang, Sheila McCormick, and Jorge Muschietti
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6860–6865. Published online 2003 May 14. doi: 10.1073/pnas.0631728100.
PMCID: PMC164537
Crosstalk between cytosolic and plastidial pathways of isoprenoid biosynthesis in Arabidopsis thaliana
Oliver Laule, Andreas Fürholz, Hur-Song Chang, Tong Zhu, Xun Wang, Peter B. Heifetz, Wilhelm Gruissem, and Markus Lange
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6866–6871. Published online 2003 May 14. doi: 10.1073/pnas.1031755100.
PMCID: PMC164538
The putative glutamate receptor 1.1 (AtGLR1.1) functions as a regulator of carbon and nitrogen metabolism in Arabidopsis thaliana
Jiman Kang and Frank J. Turano
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6872–6877. Published online 2003 May 8. doi: 10.1073/pnas.1030961100.
PMCID: PMC164539
Two Arabidopsis circadian oscillators can be distinguished by differential temperature sensitivity
Todd P. Michael, Patrice A. Salomé, and C. Robertson McClung
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6878–6883. Published online 2003 May 7. doi: 10.1073/pnas.1131995100.
PMCID: PMC164540
Psychology
Global perception in small brains: Topological pattern recognition in honey bees
Lin Chen, Shaowu Zhang, and Mandyam V. Srinivasan
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6884–6889. Published online 2003 May 15. doi: 10.1073/pnas.0732090100.
PMCID: PMC164541
Corrections
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6890. doi: 10.1073/pnas.1231735100.
PMCID: PMC164542
Corrects: Hoon Ryu, et al. Histone deacetylase inhibitors prevent oxidative neuronal death independent of expanded polyglutamine repeats via an Sp1-dependent pathway. Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 4281–4286.
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6890. Published online 2003 May 9. doi: 10.1073/pnas.1232296100.
PMCID: PMC164543
Corrects: Elizabeth A. Kellogg. What happens to genes in duplicated genomes. Proc Natl Acad Sci U S A. 2003 April 15; 100(8): 4369–4371.
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6890. Published online 2003 May 2. doi: 10.1073/pnas.1131491100.
PMCID: PMC164544
Corrects: Muhammad Al-Hajj, et al. From the Cover:
Prospective identification of tumorigenic breast cancer cells.
Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3983–3988.
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6890. doi: 10.1073/pnas.1232295100.
PMCID: PMC164545
Corrects: Lian Fan, et al. Antigen presentation by keratinocytes directs autoimmune skin disease. Proc Natl Acad Sci U S A. 2003 March 18; 100(6): 3386–3391.
Proc Natl Acad Sci U S A. 2003 May 27; 100(11): 6891. Published online 2003 May 15. doi: 10.1073/pnas.1232068100.
PMCID: PMC164546
Corrects: Hiroshi Miyamoto, et al. 3β-Acetoxyandrost-1,5-diene-17-ethylene ketal functions as a potent antiandrogen with marginal agonist activity. Proc Natl Acad Sci U S A. 2003 April 15; 100(8): 4440–4444.
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