| | This journal provides immediate access to some articles. Editorial “Statement on scientific publication and security” fails to provide necessary guidelines Stanley Falkow PMCID: PMC156238 Commentaries Sexual selection forms the structure and dynamics of ecological communities Nils Chr. Stenseth and Glenn-Peter Saetre PMCID: PMC156239 A humble hexose monophosphate pathway metabolite regulates short- and long-term control of lipogenesis Richard L. Veech PMCID: PMC156240 More whistles and bells for fly hearing Richard G. Walker PMCID: PMC156241 New insights into ciliary function: Kidney cysts and photoreceptors James P. Calvet PMCID: PMC156242 Integration by design Suzanne Sandmeyer PMCID: PMC156243 Mind-altering miniature neurotransmitter release? Yo Otsu and Timothy H. Murphy PMCID: PMC156244 Physical Sciences Applied Mathematics Hessian eigenmaps: Locally linear embedding techniques for high-dimensional data David L. Donoho and Carrie Grimes PMCID: PMC156245 Applied Physical Sciences From the Cover:
Materials become insensitive to flaws at nanoscale: Lessons from nature Huajian Gao, Baohua Ji, Ingomar L. Jäger, Eduard Arzt, and Peter Fratzl PMCID: PMC156246 Chemistry Dual-frequency 2D-IR spectroscopy heterodyned photon echo of the peptide bond Igor V. Rubtsov, Jianping Wang, and Robin M. Hochstrasser PMCID: PMC156247 The rate of hydrolysis of phosphomonoester dianions and the exceptional catalytic proficiencies of protein and inositol phosphatases Chetan Lad, Nicholas H. Williams, and Richard Wolfenden PMCID: PMC156248 Mathematics Scaling behavior of random knots Akos Dobay, Jacques Dubochet, Kenneth Millett, Pierre-Edouard Sottas, and Andrzej Stasiak PMCID: PMC156249 Biological Sciences Biochemistry The rate of hydrolysis of phosphomonoester dianions and the exceptional catalytic proficiencies of protein and inositol phosphatases Chetan Lad, Nicholas H. Williams, and Richard Wolfenden PMCID: PMC156248 Identification of genes involved in cell invasion by using a library of randomized hybrid ribozymes Eigo Suyama, Hiroaki Kawasaki, Motowo Nakajima, and Kazunari Taira PMCID: PMC156250 Mutational analysis of predicted interactions between the catalytic and P domains of prohormone convertase 3 (PC3/PC1) Kazuya Ueda, Gregory M. Lipkind, An Zhou, Xiaorong Zhu, Andrey Kuznetsov, Louis Philipson, Paul Gardner, Chunling Zhang, and Donald F. Steiner PMCID: PMC156251 Effect of the anorectic fatty acid synthase inhibitor C75 on neuronal activity in the hypothalamus and brainstem Su Gao and M. Daniel Lane PMCID: PMC156252 Histone H1.2 is a substrate for denitrase, an activity that reduces nitrotyrosine immunoreactivity in proteins Yasuyuki Irie, Makio Saeki, Yoshinori Kamisaki, Emil Martin, and Ferid Murad PMCID: PMC156253 DNA relaxation by human topoisomerase I occurs in the closed clamp conformation of the protein James F. Carey, Sharon J. Schultz, Lisa Sisson, Thomas G. Fazzio, and James J. Champoux PMCID: PMC156254 Binding and recognition in the assembly of an active BRCA1/BARD1 ubiquitin-ligase complex Peter S. Brzovic, Jennifer R. Keeffe, Hiroyuki Nishikawa, Keiko Miyamoto, David Fox, III, Mamoru Fukuda, Tomohiko Ohta, and Rachel Klevit PMCID: PMC156255 Distinct response to dioxin in an arylhydrocarbon receptor (AHR)-humanized mouse Takashi Moriguchi, Hozumi Motohashi, Tomonori Hosoya, Osamu Nakajima, Satoru Takahashi, Seiichiroh Ohsako, Yasunobu Aoki, Noriko Nishimura, Chiharu Tohyama, Yoshiaki Fujii-Kuriyama, and Masayuki Yamamoto PMCID: PMC156256 Vancomycin analogues active against vanA-resistant strains inhibit bacterial transglycosylase without binding substrate Lan Chen, Deborah Walker, Binyuan Sun, Yanan Hu, Suzanne Walker, and Daniel Kahne PMCID: PMC156257 The mechanism of ferrichrome transport through Arn1p and its metabolism in Saccharomyces cerevisiae Robert E. Moore, Youngwoo Kim, and Caroline C. Philpott PMCID: PMC156258 Catalytic and structural role of the metal ion in dUTP pyrophosphatase Devkumar Mustafi, Angela Bekesi, Beata G. Vertessy, and Marvin W. Makinen PMCID: PMC156259 Expanding tRNA recognition of a tRNA synthetase by a single amino acid change Liang Feng, Debra Tumbula-Hansen, Helen Toogood, and Dieter Söll PMCID: PMC156260 Genomewide transcriptional changes associated with genetic alterations and nutritional supplementation affecting tryptophan metabolism in Bacillus subtilis Randy M. Berka, Xianju Cui, and Charles Yanofsky PMCID: PMC156261 NMR structure of a complex containing the TFIIF subunit RAP74 and the RNA polymerase II carboxyl-terminal domain phosphatase FCP1 Bao D. Nguyen, Karen L. Abbott, Krzysztof Potempa, Michael S. Kobor, Jacques Archambault, Jack Greenblatt, Pascale Legault, and James G. Omichinski PMCID: PMC156262 Mimicking natural evolution in vitro: An N-acetylneuraminate lyase mutant with an increased dihydrodipicolinate synthase activity Andreas C. Joerger, Sebastian Mayer, and Alan R. Fersht PMCID: PMC156263 The initiation–elongation transition: Lateral mobility of RNA in RNA polymerase II complexes is greatly reduced at +8/+9 and absent by +23 Mahadeb Pal and Donal S. Luse PMCID: PMC156264 Anthrax lethal factor represses glucocorticoid and progesterone receptor activity Jeanette I. Webster, Leonardo H. Tonelli, Mahtab Moayeri, S. Stoney Simons, Jr., Stephen H. Leppla, and Esther M. Sternberg PMCID: PMC156265 The nature of heme/iron-induced protein tyrosine nitration Ka Bian, Zhonghong Gao, Norman Weisbrodt, and Ferid Murad PMCID: PMC156266 Ever shorter telomere 1 (EST1)-dependent reverse transcription by Candida telomerase in vitro: Evidence in support of an activating function Sunitha M. Singh and Neal F. Lue PMCID: PMC156267 An unusual mechanism of bacterial gene expression revealed for the RNase P protein of Thermus strains Ralph Feltens, Markus Gößringer, Dagmar K. Willkomm, Henning Urlaub, and Roland K. Hartmann PMCID: PMC156268 Biophysics Hydrogen-exchange stability analysis of Bergerac-Src homology 3 variants allows the characterization of a folding intermediate in equilibrium Ana-Rosa Viguera and Luis Serrano PMCID: PMC156269 Tuning activation of the AMPA-sensitive GluR2 ion channel by genetic adjustment of agonist-induced conformational changes Neali Armstrong, Mark Mayer, and Eric Gouaux PMCID: PMC156270 Role of backbone solvation and electrostatics in generating preferred peptide backbone conformations: Distributions of phi Franc Avbelj and Robert L. Baldwin PMCID: PMC156271 Bacteria are not too small for spatial sensing of chemical gradients: An experimental evidence Roland Thar and Michael Kühl PMCID: PMC156272 Oxidative folding intermediates with nonnative disulfide bridges between adjacent cysteine residues Maša Čemažar, Sotir Zahariev, Jakob J. Lopez, Oliviero Carugo, Jonathan A. Jones, P. J. Hore, and Sándor Pongor PMCID: PMC156273 The structure of nonvertebrate actin: Implications for the ATP hydrolytic mechanism S. Vorobiev, B. Strokopytov, D. G. Drubin, C. Frieden, S. Ono, J. Condeelis, P. A. Rubenstein, and S. C. Almo PMCID: PMC156274 A TyrCD1/TrpG8 hydrogen bond network and a TyrB10—TyrCD1 covalent link shape the heme distal site of Mycobacterium tuberculosis hemoglobin O Mario Milani, Pierre-Yves Savard, Hugues Ouellet, Paolo Ascenzi, Michel Guertin, and Martino Bolognesi PMCID: PMC156275 Protein–protein interactions: Structurally conserved residues distinguish between binding sites and exposed protein surfaces Buyong Ma, Tal Elkayam, Haim Wolfson, and Ruth Nussinov PMCID: PMC156276 Cell Biology Secretory leukocyte protease inhibitor promotes the tumorigenic and metastatic potential of cancer cells Nick Devoogdt, Gholamreza Hassanzadeh Ghassabeh, Jing Zhang, Lea Brys, Patrick De Baetselier, and Hilde Revets PMCID: PMC156277 Membrane receptor trafficking: Evidence of proximal and distal zones conferred by two independent endoplasmic reticulum localization signals Sojin Shikano and Min Li PMCID: PMC156278 Polo-like kinase (Plk)1 depletion induces apoptosis in cancer cells Xiaoqi Liu and Raymond L. Erikson PMCID: PMC156279 Resistance of cell membranes to different detergents Sebastian Schuck, Masanori Honsho, Kim Ekroos, Andrej Shevchenko, and Kai Simons PMCID: PMC156280 A conserved function of YidC in the biogenesis of respiratory chain complexes M. van der Laan, M. L. Urbanus, C. M. ten Hagen-Jongman, N. Nouwen, B. Oudega, N. Harms, A. J. M. Driessen, and J. Luirink PMCID: PMC156281 SHED: Stem cells from human exfoliated deciduous teeth Masako Miura, Stan Gronthos, Mingrui Zhao, Bai Lu, Larry W. Fisher, Pamela Gehron Robey, and Songtao Shi PMCID: PMC156282 Unbiased quantitative proteomics of lipid rafts reveals high specificity for signaling factors Leonard J. Foster, Carmen L. de Hoog, and Matthias Mann PMCID: PMC156283 Dynamic assembly of surface structures in living cells Julia Gorelik, Andrew I. Shevchuk, Gregory I. Frolenkov, Ivan A. Diakonov, Max J. Lab, Corné J. Kros, Guy P. Richardson, Igor Vodyanoy, Christopher R. W. Edwards, David Klenerman, and Yuri E. Korchev PMCID: PMC156284 The nuclear pore complex protein ALADIN is mislocalized in triple A syndrome Janet M. Cronshaw and Michael J. Matunis PMCID: PMC156285 Developmental Biology Generation of neural crest-derived peripheral neurons and floor plate cells from mouse and primate embryonic stem cells Kenji Mizuseki, Tatsunori Sakamoto, Kiichi Watanabe, Keiko Muguruma, Makoto Ikeya, Ayaka Nishiyama, Akiko Arakawa, Hirofumi Suemori, Norio Nakatsuji, Hiroshi Kawasaki, Fujio Murakami, and Yoshiki Sasai PMCID: PMC156286 A Wnt- and β-catenin-dependent pathway for mammalian cardiac myogenesis Teruya Nakamura, Motoaki Sano, Zhou Songyang, and Michael D. Schneider PMCID: PMC156287 Mesenchymal progenitor self-renewal deficiency leads to age-dependent osteoporosis in Sca-1/Ly-6A null mice Mortaza Bonyadi, Stephen D. Waldman, Danmei Liu, Jane E. Aubin, Marc D. Grynpas, and William L. Stanford PMCID: PMC156288 Requirement for Pangolin/dTCF in Drosophila Wingless signaling Liang Schweizer, Denise Nellen, and Konrad Basler PMCID: PMC156289 Ecology From the Cover:
Tropical rain forest tree growth and atmospheric carbon dynamics linked to interannual temperature variation during 1984–2000 D. A. Clark, S. C. Piper, C. D. Keeling, and D. B. Clark PMCID: PMC156290 From the Cover:
Sexual selection affects local extinction and turnover in bird communities Paul F. Doherty, Jr., Gabriele Sorci, J. Andrew Royle, James E. Hines, James D. Nichols, and Thierry Boulinier PMCID: PMC156291 Long-term memory for a life on the move Claudia Mettke-Hofmann and Eberhard Gwinner PMCID: PMC156292 Evolution Cryptic species of fig-pollinating wasps: Implications for the evolution of the fig–wasp mutualism, sex allocation, and precision of adaptation Drude Molbo, Carlos A. Machado, Jan G. Sevenster, Laurent Keller, and Edward Allen Herre PMCID: PMC156293 Adaptive evolution of cytochrome c oxidase subunit VIII in anthropoid primates Allon Goldberg, Derek E. Wildman, Timothy R. Schmidt, Maik Hüttemann, Morris Goodman, Mark L. Weiss, and Lawrence I. Grossman PMCID: PMC156294 A molecular approach to comparative phylogeography of extant Malagasy lemurs Jennifer Pastorini, Urs Thalmann, and Robert D. Martin PMCID: PMC156295 The loss of the hemoglobin H2S-binding function in annelids from sulfide-free habitats reveals molecular adaptation driven by Darwinian positive selection Xavier Bailly, Riwanon Leroy, Susan Carney, Olivier Collin, Franck Zal, André Toulmond, and Didier Jollivet PMCID: PMC156296 Genetics From the Cover:
Controlling integration specificity of a yeast retrotransposon Yunxia Zhu, Junbiao Dai, Peter G. Fuerst, and Daniel F. Voytas PMCID: PMC156297 Natural variation in human membrane transporter genes reveals evolutionary and functional constraints Maya K. Leabman, Conrad C. Huang, Joseph DeYoung, Elaine J. Carlson, Travis R. Taylor, Melanie de la Cruz, Susan J. Johns, Doug Stryke, Michiko Kawamoto, Thomas J. Urban, Deanna L. Kroetz, Thomas E. Ferrin, Andrew G. Clark, Neil Risch, Ira Herskowitz, Kathleen M. Giacomini, and Pharmacogenetics of Membrane Transporters Investigators PMCID: PMC156298 Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1 Yan Shu, Maya K. Leabman, Bo Feng, Lara M. Mangravite, Conrad C. Huang, Doug Stryke, Michiko Kawamoto, Susan J. Johns, Joseph DeYoung, Elaine Carlson, Thomas E. Ferrin, Ira Herskowitz, Kathleen M. Giacomini, and Pharmacogenetics of Membrane Transporters Investigators PMCID: PMC156299 Prevalence of defective DNA mismatch repair and MSH6 mutation in an unselected series of endometrial cancers Paul J. Goodfellow, Barbara M. Buttin, Thomas J. Herzog, Janet S. Rader, Randall K. Gibb, Elizabeth Swisher, Katherine Look, Ken C. Walls, Ming-Yu Fan, and David G. Mutch PMCID: PMC156300 Rhythmic binding of a WHITE COLLAR-containing complex to the frequency promoter is inhibited by FREQUENCY Allan C. Froehlich, Jennifer J. Loros, and Jay C. Dunlap PMCID: PMC156301 Mammalian linker-histone subtypes differentially affect gene expression in vivo Raouf Alami, Yuhong Fan, Stephanie Pack, Timothy M. Sonbuchner, Arnaud Besse, Qingcong Lin, John M. Greally, Arthur I. Skoultchi, and Eric E. Bouhassira PMCID: PMC156302 Digital genotyping and haplotyping with polymerase colonies Robi D. Mitra, Vincent L. Butty, Jay Shendure, Benjamin R. Williams, David E. Housman, and George M. Church PMCID: PMC156303 Targets of the transcriptional repressor oncoprotein Gfi-1 Zhijun Duan and Marshall Horwitz PMCID: PMC156304 Functional conservation of light, oxygen, or voltage domains in light sensing Ping Cheng, Qiyang He, Yuhong Yang, Lixin Wang, and Yi Liu PMCID: PMC156305 Reverse engineering gene networks: Integrating genetic perturbations with dynamical modeling Jesper Tegnér, M. K. Stephen Yeung, Jeff Hasty, and James J. Collins PMCID: PMC156306 A cell-based assay for aggregation inhibitors as therapeutics of polyglutamine-repeat disease and validation in Drosophila Barbara L. Apostol, Alexsey Kazantsev, Simona Raffioni, Katalin Illes, Judit Pallos, Laszlo Bodai, Natalia Slepko, James E. Bear, Frank B. Gertler, Steven Hersch, David E. Housman, J. Lawrence Marsh, and Leslie Michels Thompson PMCID: PMC156307 Parkin, a gene implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25–q27 Rossano Cesari, Eric S. Martin, George A. Calin, Francesca Pentimalli, Roberta Bichi, Holly McAdams, Francesco Trapasso, Alessandra Drusco, Masayoshi Shimizu, Valeria Masciullo, Giuseppina d'Andrilli, Giovanni Scambia, Maria Cristina Picchio, Hansjuerg Alder, Andrew K. Godwin, and Carlo M. Croce PMCID: PMC156308 Efficient linking and transfer of multiple genes by a multigene assembly and transformation vector system Li Lin, Yao-Guang Liu, Xinping Xu, and Baojian Li PMCID: PMC156309 Substoichiometric shifting in the plant mitochondrial genome is influenced by a gene homologous to MutS Ricardo V. Abdelnoor, Ryan Yule, Annakaisa Elo, Alan C. Christensen, Gilbert Meyer-Gauen, and Sally A. Mackenzie PMCID: PMC156310 Gene expression profiles of human breast cancer progression Xiao-Jun Ma, Ranelle Salunga, J. Todd Tuggle, Justin Gaudet, Edward Enright, Philip McQuary, Terry Payette, Maria Pistone, Kimberly Stecker, Brian M. Zhang, Yi-Xiong Zhou, Heike Varnholt, Barbara Smith, Michelle Gadd, Erica Chatfield, Jessica Kessler, Thomas M. Baer, Mark G. Erlander, and Dennis C. Sgroi PMCID: PMC156311 A novel class of gene controlling virulence in plant pathogenic ascomycete fungi Shun-Wen Lu, Scott Kroken, Bee-Na Lee, Barbara Robbertse, Alice C. L. Churchill, O. C. Yoder, and B. Gillian Turgeon PMCID: PMC156312 Immunology IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist Susumu Nakae, Shinobu Saijo, Reiko Horai, Katsuko Sudo, Shigeo Mori, and Yoichiro Iwakura PMCID: PMC156313 Caspase-mediated processing of the Drosophila NF-κB factor Relish Svenja Stöven, Neal Silverman, Anna Junell, Marika Hedengren-Olcott, Deniz Erturk, Ylva Engström, Tom Maniatis, and Dan Hultmark PMCID: PMC156314 A high-frequency polymorphism in exon 6 of the CD45 tyrosine phosphatase gene (PTPRC) resulting in altered isoform expression Tara Stanton, Sally Boxall, Kouzo Hirai, Ritu Dawes, Susan Tonks, Tomoyo Yasui, Yasushi Kanaoka, Nadira Yuldasheva, Osamu Ishiko, Walter Bodmer, Peter C. L. Beverley, and Elma Z. Tchilian PMCID: PMC156315 Activation of CD4 T cells by Raf-independent effectors of Ras Jan Czyzyk, Jennifer L. Brogdon, Abdallah Badou, Octavian Henegariu, Paula Preston Hurlburt, Richard Flavell, and Kim Bottomly PMCID: PMC156316 Antigens in tea-beverage prime human Vγ2Vδ2 T cells in vitro and in vivo for memory and nonmemory antibacterial cytokine responses Arati B. Kamath, Lisheng Wang, Hiranmoy Das, Lin Li, Vernon N. Reinhold, and Jack F. Bukowski PMCID: PMC156317 Public versus personal serotypes of a viral quasispecies Lukas Hunziker, Adrian Ciurea, Mike Recher, Hans Hengartner, and Rolf M. Zinkernagel PMCID: PMC156318 On the role of MHC class II molecules in the survival and lymphopenia-induced proliferation of peripheral CD4+ T cells Bruno Martin, Christine Bourgeois, Nicole Dautigny, and Bruno Lucas PMCID: PMC156319 Medical Sciences Targeted deletion of histidine decarboxylase gene in mice increases bone formation and protects against ovariectomy-induced bone loss L. A. Fitzpatrick, E. Buzas, T. J. Gagne, A. Nagy, C. Horvath, V. Ferencz, A. Mester, B. Kari, M. Ruan, A. Falus, and J. Barsony PMCID: PMC156320 Deletion of neuropeptide Y (NPY) 2 receptor in mice results in blockage of NPY-induced angiogenesis and delayed wound healing A. Jonas Ekstrand, Renhai Cao, Meit Björndahl, Susanne Nyström, Ann-Cathrine Jönsson-Rylander, Hessameh Hassani, Bengt Hallberg, Margareta Nordlander, and Yihai Cao PMCID: PMC156321 Immunomicelles: Targeted pharmaceutical carriers for poorly soluble drugs Vladimir P. Torchilin, Anatoly N. Lukyanov, Zhonggao Gao, and Brigitte Papahadjopoulos-Sternberg PMCID: PMC156322 SPARC-null mice exhibit increased adiposity without significant differences in overall body weight A. D. Bradshaw, D. C. Graves, K. Motamed, and E. H. Sage PMCID: PMC156323 Cloning of an Alpha-TFEB fusion in renal tumors harboring the t(6;11)(p21;q13) chromosome translocation Ian J. Davis, Bae-Li Hsi, Jason D. Arroyo, Sara O. Vargas, Y. Albert Yeh, Gabriela Motyckova, Patricia Valencia, Antonio R. Perez-Atayde, Pedram Argani, Marc Ladanyi, Jonathan A. Fletcher, and David E. Fisher PMCID: PMC156324 Perturbations in B cell responsiveness to CD4+ T cell help in HIV-infected individuals Susan Moir, Kisani M. Ogwaro, Angela Malaspina, Joshua Vasquez, Eileen T. Donoghue, Claire W. Hallahan, Shuying Liu, Linda A. Ehler, Marie A. Planta, Shyamasundaran Kottilil, Tae-Wook Chun, and Anthony S. Fauci PMCID: PMC156325 Keratin 8 and 18 mutations are risk factors for developing liver disease of multiple etiologies Nam-On Ku, Jama M. Darling, Sheri M. Krams, Carlos O. Esquivel, Emmet B. Keeffe, Richard K. Sibley, Young Moo Lee, Teresa L. Wright, and M. Bishr Omary PMCID: PMC156326 Linkage disequilibrium in human populations Christine Lonjou, Weihua Zhang, Andrew Collins, William J. Tapper, Eiram Elahi, Nikolas Maniatis, and Newton E. Morton PMCID: PMC156327 Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility Irina Smirnova, Navjiwan Mann, Annemiek Dols, H. H. Derkx, Martin L. Hibberd, Michael Levin, and Bruce Beutler PMCID: PMC156328 Adeno-associated viruses undergo substantial evolution in primates during natural infections Guangping Gao, Mauricio R. Alvira, Suryanarayan Somanathan, You Lu, Luk H. Vandenberghe, John J. Rux, Roberto Calcedo, Julio Sanmiguel, Zahra Abbas, and James M. Wilson PMCID: PMC156329 Tauroursodeoxycholic acid reduces apoptosis and protects against neurological injury after acute hemorrhagic stroke in rats Cecilia M. P. Rodrigues, Susana Solá, Zhenhong Nan, Rui E. Castro, Paulo S. Ribeiro, Walter C. Low, and Clifford J. Steer PMCID: PMC156330 Ultra-high-pressure inactivation of prion infectivity in processed meat: A practical method to prevent human infection Paul Brown, Richard Meyer, Franco Cardone, and Maurizio Pocchiari PMCID: PMC156331 Inducible expression of keratinocyte growth factor (KGF) in mice inhibits lung epithelial cell death induced by hyperoxia Prabir Ray, Yvan Devaux, Donna B. Stolz, Manohar Yarlagadda, Simon C. Watkins, Yunbiao Lu, Li Chen, Xiao-fang Yang, and Anuradha Ray PMCID: PMC156332 The hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives Davor Pavlović, David C. A. Neville, Olivier Argaud, Baruch Blumberg, Raymond A. Dwek, Wolfgang B. Fischer, and Nicole Zitzmann PMCID: PMC156333 Heterogeneous nuclear ribonucleoprotein (hnRNP) binding to hormone response elements: A cause of vitamin D resistance Hong Chen, Martin Hewison, Bing Hu, and John S. Adams PMCID: PMC156334 Microbiology Folding quality control in the export of proteins by the bacterial twin-arginine translocation pathway Matthew P. DeLisa, Danielle Tullman, and George Georgiou PMCID: PMC156335 MmpL8 is required for sulfolipid-1 biosynthesis and Mycobacterium tuberculosis virulence Scott E. Converse, Joseph D. Mougous, Michael D. Leavell, Julie A. Leary, Carolyn R. Bertozzi, and Jeffery S. Cox PMCID: PMC156336 Iron chelators modulate the fusogenic properties of Salmonella-containing phagosomes Nada Jabado, Patricia Cuellar-Mata, Sergio Grinstein, and Philippe Gros PMCID: PMC156337 The two-component PhoR-PhoP system controls both primary metabolism and secondary metabolite biosynthesis in Streptomyces lividans A. Sola-Landa, R. S. Moura, and J. F. Martín PMCID: PMC156338 Neuroscience From the Cover:
Nifedipine facilitates neurotransmitter release independently of calcium channels Michiru Hirasawa and Quentin J. Pittman PMCID: PMC156339 NADPH oxidase mediates oxidative stress in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease Du-Chu Wu, Peter Teismann, Kim Tieu, Miquel Vila, Vernice Jackson-Lewis, Harry Ischiropoulos, and Serge Przedborski PMCID: PMC156340 A unifying basis of auditory thresholds based on temporal summation Peter Heil and Heinrich Neubauer PMCID: PMC156341 Modulation of mitochondrial function by endogenous Zn2+ pools Stefano L. Sensi, Dien Ton-That, Patrick G. Sullivan, Elizabeth A. Jonas, Kyle R. Gee, Leonard K. Kaczmarek, and John H. Weiss PMCID: PMC156342 Complex movements evoked by microstimulation of the ventral intraparietal area Dylan F. Cooke, Charlotte S. R. Taylor, Tirin Moore, and Michael S. A. Graziano PMCID: PMC156343 Acetylcholine enhancement in the nucleus accumbens prevents addictive behaviors of cocaine and morphine Takatoshi Hikida, Yasuji Kitabatake, Ira Pastan, and Shigetada Nakanishi PMCID: PMC156344 Change of conduction velocity by regional myelination yields constant latency irrespective of distance between thalamus and cortex Mahmoud Salami, Chiaki Itami, Tadaharu Tsumoto, and Fumitaka Kimura PMCID: PMC156345 Transgenic overexpression of galanin in the dorsal root ganglia modulates pain-related behavior Fiona E. Holmes, Andrea Bacon, Robert J. P. Pope, Penny A. Vanderplank, Niall C. H. Kerr, Madhu Sukumaran, Vassilis Pachnis, and David Wynick PMCID: PMC156346 Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine Venkata S. Mattay, Terry E. Goldberg, Francesco Fera, Ahmad R. Hariri, Alessandro Tessitore, Michael F. Egan, Bhaskar Kolachana, Joseph H. Callicott, and Daniel R. Weinberger PMCID: PMC156347 An estrogen-dependent four-gene micronet regulating social recognition: A study with oxytocin and estrogen receptor-α and -β knockout mice Elena Choleris, Jan-Åke Gustafsson, Kenneth S. Korach, Louis J. Muglia, Donald W. Pfaff, and Sonoko Ogawa PMCID: PMC156348 Identification and characterization of a G protein-coupled receptor for the neuropeptide proctolin in Drosophila melanogaster Erik C. Johnson, Stephen F. Garczynski, Dongkook Park, Joe W. Crim, Dick R. Nässel, and Paul H. Taghert PMCID: PMC156349 Adeno-associated viral transfer of opioid receptor gene to primary sensory neurons: A strategy to increase opioid antinociception Y. Xu, Y. Gu, G.-Y. Xu, P. Wu, G.-W. Li, and L.-Y. M. Huang PMCID: PMC156350 Postinsult treatment with lithium reduces brain damage and facilitates neurological recovery in a rat ischemia/reperfusion model Ming Ren, Vladimir V. Senatorov, Ren-Wu Chen, and De-Maw Chuang PMCID: PMC156351 Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake R. Michael Anson, Zhihong Guo, Rafael de Cabo, Titilola Iyun, Michelle Rios, Adrienne Hagepanos, Donald K. Ingram, Mark A. Lane, and Mark P. Mattson PMCID: PMC156352 Amyloid-β peptide levels in brain are inversely correlated with insulysin activity levels in vivo Bonnie C. Miller, Elizabeth A. Eckman, Kumar Sambamurti, Nicole Dobbs, K. Martin Chow, Christopher B. Eckman, Louis B. Hersh, and Dwain L. Thiele PMCID: PMC156353 Behavioral, neurochemical, and electrophysiological characterization of a genetic mouse model of depression Malika El Yacoubi, Saoussen Bouali, Daniela Popa, Laurent Naudon, Isabelle Leroux-Nicollet, Michel Hamon, Jean Costentin, Joëlle Adrien, and Jean-Marie Vaugeois PMCID: PMC156354 Pharmacology Protein kinase involved in lung injury susceptibility: Evidence from enzyme isoform genetic knockout and in vivo inhibitor treatment Mark S. Wainwright, Janet Rossi, James Schavocky, Susan Crawford, David Steinhorn, Anastasia V. Velentza, Magdalena Zasadzki, Vladimir Shirinsky, Yuzhi Jia, Jacques Haiech, Linda J. Van Eldik, and D. Martin Watterson PMCID: PMC156355 Agonist unbinding from receptor dictates the nature of deactivation kinetics of G protein-gated K+ channels Amy Benians, Joanne L. Leaney, and Andrew Tinker PMCID: PMC156356 Characterization of the endokinins: Human tachykinins with cardiovascular activity Nigel M. Page, Nicola J. Bell, Sheila M. Gardiner, Isaac T. Manyonda, Kerensa J. Brayley, Philip G. Strange, and Philip J. Lowry PMCID: PMC156357 Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8 Hirokazu Tanaka, Tetsuo Yoshida, Norimasa Miyamoto, Toshiyuki Motoike, Hiroshi Kurosu, Kenji Shibata, Akihiro Yamanaka, S. Clay Williams, James A. Richardson, Natsuko Tsujino, Mary G. Garry, Michael R. Lerner, David S. King, Brian F. O'Dowd, Takeshi Sakurai, and Masashi Yanagisawa PMCID: PMC156358 Physiology The Na/K pump, Cl ion, and osmotic stabilization of cells Clay M. Armstrong PMCID: PMC156359 Plant Biology Positional cloning of the wheat vernalization gene VRN1 L. Yan, A. Loukoianov, G. Tranquilli, M. Helguera, T. Fahima, and J. Dubcovsky PMCID: PMC156360 Phototropin is the blue-light receptor that controls multiple steps in the sexual life cycle of the green alga Chlamydomonas reinhardtii Kaiyao Huang and Christoph F. Beck PMCID: PMC156361 Psychology Different time courses for visual perception and action priming Dirk Vorberg, Uwe Mattler, Armin Heinecke, Thomas Schmidt, and Jens Schwarzbach PMCID: PMC156362 Social Sciences Psychology INAUGURAL ARTICLE by a Recently Elected Academy Member: A quantitative model for transforming reflectance spectra into the Munsell color space using cone sensitivity functions and opponent process weights Roy G. D'Andrade and A. Kimball Romney PMCID: PMC156363 Corrections Proc Natl Acad Sci U S A. 2003 May 13; 100(10): 6287. Published online 2003 April 29. doi: 10.1073/pnas.1131752100.PMCID: PMC156236 Corrects: Richard J. S. Burchmore, et al. Genetic characterization of glucose transporter function in Leishmania mexicana. Proc Natl Acad Sci U S A. 2003 April 1; 100(7): 3901–3906. Proc Natl Acad Sci U S A. 2003 May 13; 100(10): 6287. Published online 2003 April 29. doi: 10.1073/pnas.1038066100.PMCID: PMC156237 Corrects: Berenike Maier, et al. Single pilus motor forces exceed 100 pN. Proc Natl Acad Sci U S A. 2002 December 10; 99(25): 16012–16017. |
