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Volume 100(9);  April 29, 2003
Commentaries
A slippery boundary
Andrew G. Clark
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 4971–4972. Published online 2003 April 18. doi: 10.1073/pnas.0931310100.
PMCID: PMC154279
Low-dose radiation: Thresholds, bystander effects, and adaptive responses
William M. Bonner
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 4973–4975. Published online 2003 April 18. doi: 10.1073/pnas.1031538100.
PMCID: PMC154280
Knockout of the guard cell K+out channel and stomatal movements
Julian I. Schroeder
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 4976–4977. Published online 2003 April 18. doi: 10.1073/pnas.1031801100.
PMCID: PMC154281
Nitroxyl gets to the heart of the matter
Martin Feelisch
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 4978–4980. Published online 2003 April 18. doi: 10.1073/pnas.1031571100.
PMCID: PMC154282
Does clathrin pull the fission trigger?
Gilbert Di Paolo and Pietro De Camilli
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 4981–4983. Published online 2003 April 18. doi: 10.1073/pnas.0930650100.
PMCID: PMC154283
Physical Sciences
Applied Physical Sciences
Noncovalent functionalization of carbon nanotubes for highly specific electronic biosensors
Robert J. Chen, Sarunya Bangsaruntip, Katerina A. Drouvalakis, Nadine Wong Shi Kam, Moonsub Shim, Yiming Li, Woong Kim, Paul J. Utz, and Hongjie Dai
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 4984–4989. Published online 2003 April 15. doi: 10.1073/pnas.0837064100.
PMCID: PMC154284
Chemistry
Observation of the cascaded atomic-to-global length scales driving protein motion
M. R. Armstrong, J. P. Ogilvie, M. L. Cowan, A. M. Nagy, and R. J. D. Miller
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 4990–4994. Published online 2003 April 15. doi: 10.1073/pnas.0936507100.
PMCID: PMC154285
A macromolecular delivery vehicle for protein-based vaccines: Acid-degradable protein-loaded microgels
Niren Murthy, Mingcheng Xu, Stephany Schuck, Jun Kunisawa, Nilabh Shastri, and Jean M. J. Fréchet
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 4995–5000. Published online 2003 April 18. doi: 10.1073/pnas.0930644100.
PMCID: PMC154286
Total chemical synthesis of a functional interacting protein pair: The protooncogene H-Ras and the Ras-binding domain of its effector c-Raf1
Christian F. W. Becker, Christie L. Hunter, Ralf Seidel, Stephen B. H. Kent, Roger S. Goody, and Martin Engelhard
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5075–5080. Published online 2003 April 18. doi: 10.1073/pnas.0831227100.
PMCID: PMC154300
Physics
Lessons from Kepler and the theory of everything
Lincoln Wolfenstein
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5001–5003. Published online 2003 April 17. doi: 10.1073/pnas.0931283100.
PMCID: PMC154287
Biological Sciences
Agricultural Sciences
Three cadherin alleles associated with resistance to Bacillus thuringiensis in pink bollworm
Shai Morin, Robert W. Biggs, Mark S. Sisterson, Laura Shriver, Christa Ellers-Kirk, Dawn Higginson, Daniel Holley, Linda J. Gahan, David G. Heckel, Yves Carrière, Timothy J. Dennehy, Judith K. Brown, and Bruce E. Tabashnik
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5004–5009. Published online 2003 April 14. doi: 10.1073/pnas.0831036100.
PMCID: PMC154288
Applied Biological Sciences
Molecular characterization of the 1,3-propanediol (1,3-PD) operon of Clostridium butyricum
Céline Raynaud, Patricia Sarçabal, Isabelle Meynial-Salles, Christian Croux, and Philippe Soucaille
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5010–5015. Published online 2003 April 18. doi: 10.1073/pnas.0734105100.
PMCID: PMC154289
Targeting therapeutics to an exposed and conserved binding element of the HIV-1 fusion protein
Michael J. Root and Dean H. Hamer
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5016–5021. Published online 2003 April 17. doi: 10.1073/pnas.0936926100.
PMCID: PMC154290
Use of combinatorial genetic libraries to humanize N-linked glycosylation in the yeast Pichia pastoris
Byung-Kwon Choi, Piotr Bobrowicz, Robert C. Davidson, Stephen R. Hamilton, David H. Kung, Huijuan Li, Robert G. Miele, Juergen H. Nett, Stefan Wildt, and Tillman U. Gerngross
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5022–5027. Published online 2003 April 17. doi: 10.1073/pnas.0931263100.
PMCID: PMC154291
Inhibition of rat corneal angiogenesis by a nuclease-resistant RNA aptamer specific for angiopoietin-2
Rebekah R. White, Siqing Shan, Christopher P. Rusconi, Geetha Shetty, Mark W. Dewhirst, Christopher D. Kontos, and Bruce A. Sullenger
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5028–5033. Published online 2003 April 11. doi: 10.1073/pnas.0831159100.
PMCID: PMC154292
Glucagon-like peptide 1 (1–37) converts intestinal epithelial cells into insulin-producing cells
Atsushi Suzuki, Hiromitsu Nakauchi, and Hideki Taniguchi
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5034–5039. Published online 2003 April 17. doi: 10.1073/pnas.0936260100.
PMCID: PMC154293
Biochemistry
Sarcolipin regulates sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) by binding to transmembrane helices alone or in association with phospholamban
Michio Asahi, Yuji Sugita, Kazimierz Kurzydlowski, Stella De Leon, Michihiko Tada, Chikashi Toyoshima, and David H. MacLennan
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5040–5045. Published online 2003 April 11. doi: 10.1073/pnas.0330962100.
PMCID: PMC154294
Endonuclease cleavage of blocked replication forks: An indirect pathway of DNA damage from antitumor drug–topoisomerase complexes
George Hong and Kenneth N. Kreuzer
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5046–5051. Published online 2003 April 18. doi: 10.1073/pnas.0835166100.
PMCID: PMC154295
The riboswitch-mediated control of sulfur metabolism in bacteria
Vitaly Epshtein, Alexander S. Mironov, and Evgeny Nudler
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5052–5056. Published online 2003 April 17. doi: 10.1073/pnas.0531307100.
PMCID: PMC154296
From the Cover:
Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses
Kai Rothkamm and Markus Löbrich
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5057–5062. Published online 2003 April 4. doi: 10.1073/pnas.0830918100.
PMCID: PMC154297
The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism
Michael Engel, Torsten Hoffmann, Leona Wagner, Michael Wermann, Ulrich Heiser, Reiner Kiefersauer, Robert Huber, Wolfram Bode, Hans-Ulrich Demuth, and Hans Brandstetter
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5063–5068. Published online 2003 April 10. doi: 10.1073/pnas.0230620100.
PMCID: PMC154298
Moth chemosensory protein exhibits drastic conformational changes and cooperativity on ligand binding
Valérie Campanacci, Audrey Lartigue, B. Martin Hällberg, T. Alwyn Jones, Marie-Therèse Giudici-Orticoni, Mariella Tegoni, and Christian Cambillau
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5069–5074. Published online 2003 April 15. doi: 10.1073/pnas.0836654100.
PMCID: PMC154299
Total chemical synthesis of a functional interacting protein pair: The protooncogene H-Ras and the Ras-binding domain of its effector c-Raf1
Christian F. W. Becker, Christie L. Hunter, Ralf Seidel, Stephen B. H. Kent, Roger S. Goody, and Martin Engelhard
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5075–5080. Published online 2003 April 18. doi: 10.1073/pnas.0831227100.
PMCID: PMC154300
γ2 subunit of G protein heterotrimer is an N-end rule ubiquitylation substrate
Maria H. Hamilton, Lana A. Cook, Theodore R. McRackan, Kevin L. Schey, and John D. Hildebrandt
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5081–5086. Published online 2003 April 16. doi: 10.1073/pnas.0831228100.
PMCID: PMC154301
Group B streptococcal phospholipid causes pulmonary hypertension
Jerri Curtis, Geumsoo Kim, Nancy B. Wehr, and Rodney L. Levine
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5087–5090. Published online 2003 April 17. doi: 10.1073/pnas.0931493100.
PMCID: PMC154302
Identifying residue–residue clashes in protein hybrids by using a second-order mean-field approach
Gregory L. Moore and Costas D. Maranas
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5091–5096. Published online 2003 April 16. doi: 10.1073/pnas.0831190100.
PMCID: PMC154303
Activation of archaeal transcription by recruitment of the TATA-binding protein
Mohamed Ouhammouch, Robert E. Dewhurst, Winfried Hausner, Michael Thomm, and E. Peter Geiduschek
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5097–5102. Published online 2003 April 11. doi: 10.1073/pnas.0837150100.
PMCID: PMC154304
Stable and controllable RNA interference: Investigating the physiological function of glutathionylated actin
Jun Wang, Ephrem Tekle, Hammou Oubrahim, John J. Mieyal, Earl R. Stadtman, and P. Boon Chock
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5103–5106. Published online 2003 April 15. doi: 10.1073/pnas.0931345100.
PMCID: PMC154305
Xylulose 5-phosphate mediates glucose-induced lipogenesis by xylulose 5-phosphate-activated protein phosphatase in rat liver
Tsutomu Kabashima, Takumi Kawaguchi, Brian E. Wadzinski, and Kosaku Uyeda
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5107–5112. Published online 2003 April 8. doi: 10.1073/pnas.0730817100.
PMCID: PMC154306
Yeast DNA polymerase η makes functional contacts with the DNA minor groove only at the incoming nucleoside triphosphate
M. Todd Washington, William T. Wolfle, Thomas E. Spratt, Louise Prakash, and Satya Prakash
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5113–5118. Published online 2003 April 11. doi: 10.1073/pnas.0837578100.
PMCID: PMC154307
Plasma antioxidant status and cell injury after severe physical exercise
Shlomit Chevion, Danny S. Moran, Yuval Heled, Yoav Shani, Gilad Regev, Benny Abbou, Eduard Berenshtein, Earl R. Stadtman, and Yoram Epstein
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5119–5123. Published online 2003 April 17. doi: 10.1073/pnas.0831097100.
PMCID: PMC154308
Inactivation of androgen receptor coregulator ARA55 inhibits androgen receptor activity and agonist effect of antiandrogens in prostate cancer cells
Mujib M. Rahman, Hiroshi Miyamoto, Henry Lardy, and Chawnshang Chang
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5124–5129. Published online 2003 April 16. doi: 10.1073/pnas.0530097100.
PMCID: PMC154309
Modulation of p47PHOX activity by site-specific phosphorylation: Akt-dependent activation of the NADPH oxidase
Carolyn R. Hoyal, Abel Gutierrez, Brandon M. Young, Sergio D. Catz, Jun-Hsiang Lin, Philip N. Tsichlis, and Bernard M. Babior
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5130–5135. Published online 2003 April 18. doi: 10.1073/pnas.1031526100.
PMCID: PMC154310
Biophysics
On schemes of combinatorial transcription logic
Nicolas E. Buchler, Ulrich Gerland, and Terence Hwa
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5136–5141. Published online 2003 April 17. doi: 10.1073/pnas.0930314100.
PMCID: PMC404558
The molecular basis for the chemical denaturation of proteins by urea
Brian J. Bennion and Valerie Daggett
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5142–5147. Published online 2003 April 17. doi: 10.1073/pnas.0930122100.
PMCID: PMC154312
Simulating disorder–order transitions in molecular recognition of unstructured proteins: Where folding meets binding
Gennady M. Verkhivker, Djamal Bouzida, Daniel K. Gehlhaar, Paul A. Rejto, Stephan T. Freer, and Peter W. Rose
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5148–5153. Published online 2003 April 15. doi: 10.1073/pnas.0531373100.
PMCID: PMC154313
The role of side-chain interactions in the early steps of aggregation: Molecular dynamics simulations of an amyloid-forming peptide from the yeast prion Sup35
Jörg Gsponer, Urs Haberthür, and Amedeo Caflisch
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5154–5159. Published online 2003 April 16. doi: 10.1073/pnas.0835307100.
PMCID: PMC154314
A defined protein–detergent–lipid complex for crystallization of integral membrane proteins: The cytochrome b6f complex of oxygenic photosynthesis
Huamin Zhang, Genji Kurisu, Janet L. Smith, and William A. Cramer
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5160–5163. Published online 2003 April 17. doi: 10.1073/pnas.0931431100.
PMCID: PMC154315
Cell Biology
Band 3 is a host receptor binding merozoite surface protein 1 during the Plasmodium falciparum invasion of erythrocytes
Vikas K. Goel, Xuerong Li, Huiqing Chen, Shih-Chun Liu, Athar H. Chishti, and Steven S. Oh
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5164–5169. Published online 2003 April 11. doi: 10.1073/pnas.0834959100.
PMCID: PMC154316
Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor
Heather M. Scobie, G. Jonah A. Rainey, Kenneth A. Bradley, and John A. T. Young
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5170–5174. Published online 2003 April 16. doi: 10.1073/pnas.0431098100.
PMCID: PMC154317
From the Cover:
Clathrin-coated pits with long, dynamin-wrapped necks upon expression of a clathrin antisense RNA
T.-G. Iversen, G. Skretting, B. van Deurs, and K. Sandvig
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5175–5180. Published online 2003 April 7. doi: 10.1073/pnas.0534231100.
PMCID: PMC154318
Cell spreading controls endoplasmic and nuclear calcium: A physical gene regulation pathway from the cell surface to the nucleus
Naoki Itano, Shu-ichi Okamoto, Dongxian Zhang, Stuart A. Lipton, and Erkki Ruoslahti
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5181–5186. Published online 2003 April 17. doi: 10.1073/pnas.0531397100.
PMCID: PMC154319
Phosphatidylinositol 4-kinase serves as a metabolic sensor and regulates priming of secretory granules in pancreatic β cells
Hervør L. Olsen, Marianne Høy, Wei Zhang, Alejandro M. Bertorello, Krister Bokvist, Kirsten Capito, Alexander M. Efanov, Björn Meister, Peter Thams, Shao-Nian Yang, Patrik Rorsman, Per-Olof Berggren, and Jesper Gromada
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5187–5192. Published online 2003 April 16. doi: 10.1073/pnas.0931282100.
PMCID: PMC154320
Cripto forms a complex with activin and type II activin receptors and can block activin signaling
Peter C. Gray, Craig A. Harrison, and Wylie Vale
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5193–5198. Published online 2003 April 7. doi: 10.1073/pnas.0531290100.
PMCID: PMC154321
Chaperone action in the posttranslational topological reorientation of the hepatitis B virus large envelope protein: Implications for translocational regulation
Carsten Lambert and Reinhild Prange
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5199–5204. Published online 2003 April 15. doi: 10.1073/pnas.0930813100.
PMCID: PMC154322
Acidic pH induces topoisomerase II-mediated DNA damage
Hai Xiao, Tsai-Kun Li, Jin-Ming Yang, and Leroy F. Liu
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5205–5210. Published online 2003 April 11. doi: 10.1073/pnas.0935978100.
PMCID: PMC154323
Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: A potential link between genome surveillance and apoptosis
Robert A. Screaton, Stephan Kiessling, Owen J. Sansom, Catherine B. Millar, Kathryn Maddison, Adrian Bird, Alan R. Clarke, and Steven M. Frisch
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5211–5216. Published online 2003 April 17. doi: 10.1073/pnas.0431215100.
PMCID: PMC154324
Developmental Biology
A genetic model for a central (septum transversum) congenital diaphragmatic hernia in mice lacking Slit3
Wenlin Yuan, Yi Rao, Randal P. Babiuk, John Greer, Jane Y. Wu, and David M. Ornitz
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5217–5222. Published online 2003 April 17. doi: 10.1073/pnas.0730709100.
PMCID: PMC154325
The functional analysis of insulator interactions in the Drosophila embryo
Parimal Majumder and Haini N. Cai
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5223–5228. Published online 2003 April 16. doi: 10.1073/pnas.0830190100.
PMCID: PMC154326
Reversal of developmental restrictions in neural crest lineages: Transition from Schwann cells to glial-melanocytic precursors in vitro
Elisabeth Dupin, Carla Real, Corinne Glavieux-Pardanaud, Pierre Vaigot, and Nicole M. Le Douarin
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5229–5233. Published online 2003 April 17. doi: 10.1073/pnas.0831229100.
PMCID: PMC154327
Protein O-fucosyltransferase 1 is an essential component of Notch signaling pathways
Shaolin Shi and Pamela Stanley
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5234–5239. Published online 2003 April 15. doi: 10.1073/pnas.0831126100.
PMCID: PMC154328
BIR-1, a Caenorhabditis elegans homologue of Survivin, regulates transcription and development
Marta Kostrouchova, Zdenek Kostrouch, Vladimir Saudek, Joram Piatigorsky, and Joseph Edward Rall
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5240–5245. Published online 2003 April 7. doi: 10.1073/pnas.0730770100.
PMCID: PMC154329
Ecology
Predicted correspondence between species abundances and dendrograms of niche similarities
George Sugihara, Louis-Félix Bersier, T. Richard E. Southwood, Stuart L. Pimm, and Robert M. May
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5246–5251. Published online 2003 April 17. doi: 10.1073/pnas.0831096100.
PMCID: PMC154330
Evolution
Directional selection has shaped the oral jaws of Lake Malawi cichlid fishes
R. Craig Albertson, J. Todd Streelman, and Thomas D. Kocher
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5252–5257. Published online 2003 April 18. doi: 10.1073/pnas.0930235100.
PMCID: PMC154331
From the Cover:
The amelogenin loci span an ancient pseudoautosomal boundary in diverse mammalian species
Mineyo Iwase, Yoko Satta, Yuriko Hirai, Hirohisa Hirai, Hirotami Imai, and Naoyuki Takahata
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5258–5263. Published online 2003 April 2. doi: 10.1073/pnas.0635848100.
PMCID: PMC154332
An obligate pollination mutualism and reciprocal diversification in the tree genus Glochidion (Euphorbiaceae)
Makoto Kato, Atsushi Takimura, and Atsushi Kawakita
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5264–5267. Published online 2003 April 14. doi: 10.1073/pnas.0837153100.
PMCID: PMC154333
The genetic basis of adaptive melanism in pocket mice
Michael W. Nachman, Hopi E. Hoekstra, and Susan L. D'Agostino
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5268–5273. Published online 2003 April 18. doi: 10.1073/pnas.0431157100.
PMCID: PMC154334
Genetics
On schemes of combinatorial transcription logic
Nicolas E. Buchler, Ulrich Gerland, and Terence Hwa
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5136–5141. Published online 2003 April 17. doi: 10.1073/pnas.0930314100.
PMCID: PMC404558
Cloning of wrinkle-free, a previously uncharacterized mouse mutation, reveals crucial roles for fatty acid transport protein 4 in skin and hair development
Casey L. Moulson, Daniel R. Martin, Jesse J. Lugus, Jean E. Schaffer, Anne C. Lind, and Jeffrey H. Miner
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5274–5279. Published online 2003 April 15. doi: 10.1073/pnas.0431186100.
PMCID: PMC154335
Hot L1s account for the bulk of retrotransposition in the human population
Brook Brouha, Joshua Schustak, Richard M. Badge, Sheila Lutz-Prigge, Alexander H. Farley, John V. Moran, and Haig H. Kazazian, Jr.
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5280–5285. Published online 2003 April 7. doi: 10.1073/pnas.0831042100.
PMCID: PMC154336
Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease
Fangming Lin, Thomas Hiesberger, Kimberly Cordes, Angus M. Sinclair, Lawrence S. B. Goldstein, Stefan Somlo, and Peter Igarashi
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5286–5291. Published online 2003 April 2. doi: 10.1073/pnas.0836980100.
PMCID: PMC154337
Dispersal of NK homeobox gene clusters in amphioxus and humans
Graham N. Luke, L. Filipe C. Castro, Kirsten McLay, Christine Bird, Alan Coulson, and Peter W. H. Holland
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5292–5295. Published online 2003 April 18. doi: 10.1073/pnas.0836141100.
PMCID: PMC154338
A 1-Mb resolution radiation hybrid map of the canine genome
Richard Guyon, Travis D. Lorentzen, Christophe Hitte, Lisa Kim, Edouard Cadieu, Heidi G. Parker, Pascale Quignon, Jennifer K. Lowe, Corinne Renier, Boris Gelfenbeyn, Françoise Vignaux, Hawkins B. DeFrance, Stephanie Gloux, Gregory G. Mahairas, Catherine André, Francis Galibert, and Elaine A. Ostrander
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5296–5301. Published online 2003 April 16. doi: 10.1073/pnas.0831002100.
PMCID: PMC154339
A rapidly evolving MYB-related protein causes species isolation in Drosophila
Daniel A. Barbash, Dominic F. Siino, Aaron M. Tarone, and John Roote
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5302–5307. Published online 2003 April 14. doi: 10.1073/pnas.0836927100.
PMCID: PMC154340
Phage HK022 Nun protein represses translation of phage λ N (transcription termination/translation repression)
Hyeong C. Kim, Jian-guang Zhou, Helen R. Wilson, Grigoriy Mogilnitskiy, Donald L. Court, and Max E. Gottesman
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5308–5312. Published online 2003 April 8. doi: 10.1073/pnas.0430995100.
PMCID: PMC154341
A strategy for identifying transcription factor binding sites reveals two classes of genomic c-Myc target sites
Timothy J. Haggerty, Karen I. Zeller, Rebecca C. Osthus, Diane R. Wonsey, and Chi V. Dang
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5313–5318. Published online 2003 April 17. doi: 10.1073/pnas.0931346100.
PMCID: PMC154342
Immunology
Impaired colonization of the gonads by primordial germ cells in mice lacking a chemokine, stromal cell-derived factor-1 (SDF-1)
Toshiaki Ara, Yuri Nakamura, Takeshi Egawa, Tatsuki Sugiyama, Kuniya Abe, Tadamitsu Kishimoto, Yasuhisa Matsui, and Takashi Nagasawa
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5319–5323. Published online 2003 April 8. doi: 10.1073/pnas.0730719100.
PMCID: PMC154343
An important regulatory role for CD4+CD8αα T cells in the intestinal epithelial layer in the prevention of inflammatory bowel disease
Gobardhan Das, Mathew M. Augustine, Jyoti Das, Kim Bottomly, Prabir Ray, and Anuradha Ray
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5324–5329. Published online 2003 April 14. doi: 10.1073/pnas.0831037100.
PMCID: PMC154344
Specificity of peptide selection by antigen-presenting cells homozygous or heterozygous for expression of class II MHC molecules: The lack of competition
Anish Suri, James J. Walters, Osami Kanagawa, Michael L. Gross, and Emil R. Unanue
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5330–5335. Published online 2003 April 7. doi: 10.1073/pnas.0330859100.
PMCID: PMC154345
PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells
P'ng Loke and James P. Allison
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5336–5341. Published online 2003 April 15. doi: 10.1073/pnas.0931259100.
PMCID: PMC154346
Autoreactive T cells can be protected from tolerance induction through competition by flanking determinants for access to class II MHC
Emanual Maverakis, Jonathan Beech, David B. Stevens, Akio Ametani, Laurent Brossay, Peter van den Elzen, Richard Mendoza, Quoc Thai, Luis H. Macias, Doug Ethell, Celia W. Campagnoni, Anthony T. Campagnoni, Alessandro Sette, and Eli E. Sercarz
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5342–5347. Published online 2003 April 21. doi: 10.1073/pnas.0936151100.
PMCID: PMC154347
Effector CD8 T cells possess suppressor function after 4-1BB and Toll-like receptor triggering
Lara Myers, Chikara Takahashi, Robert S. Mittler, Robert J. Rossi, and Anthony T. Vella
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5348–5353. Published online 2003 April 14. doi: 10.1073/pnas.0837611100.
PMCID: PMC154348
Altered positive selection due to corecognition of floppy peptide/MHC II conformers supports an integrative model of thymic selection
Christophe Viret, Xin He, and Charles A. Janeway, Jr.
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5354–5359. Published online 2003 April 16. doi: 10.1073/pnas.0831129100.
PMCID: PMC154349
Medical Sciences
Virus-like interference in the latency and prevention of Creutzfeldt–Jakob disease
Laura Manuelidis and Zhi Yun Lu
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5360–5365. Published online 2003 April 11. doi: 10.1073/pnas.0931192100.
PMCID: PMC154350
Crystal structure of human junctional adhesion molecule 1: Implications for reovirus binding
Andrea E. Prota, Jacquelyn A. Campbell, Pierre Schelling, J. Craig Forrest, Melissa J. Watson, Timothy R. Peters, Michel Aurrand-Lions, Beat A. Imhof, Terence S. Dermody, and Thilo Stehle
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5366–5371. Published online 2003 April 15. doi: 10.1073/pnas.0937718100.
PMCID: PMC404559
Oligonucleotide microarrays demonstrate the highest frequency of ATM mutations in the mantle cell subtype of lymphoma
Nicole Y. Fang, Timothy C. Greiner, Dennis D. Weisenburger, Wing C. Chan, Julie M. Vose, Lynette M. Smith, James O. Armitage, R. Aeryn Mayer, Brian L. Pike, Francis S. Collins, and Joseph G. Hacia
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5372–5377. Published online 2003 April 15. doi: 10.1073/pnas.0831102100.
PMCID: PMC154352
Telomere attrition and Chk2 activation in human heart failure
Hidemasa Oh, Sam C. Wang, Arun Prahash, Motoaki Sano, Christine S. Moravec, George E. Taffet, Lloyd H. Michael, Keith A. Youker, Mark L. Entman, and Michael D. Schneider
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5378–5383. Published online 2003 April 17. doi: 10.1073/pnas.0836098100.
PMCID: PMC154353
Cancer cachexia: Its correlations and causes
Harry Rubin
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5384–5389. Published online 2003 April 17. doi: 10.1073/pnas.0931260100.
PMCID: PMC154354
Semiquinone radical intermediate in catecholic estrogen-mediated cytotoxicity and mutagenesis: Chemoprevention strategies with antioxidants
Ayelet M. Samuni, Eric Y. Chuang, Murali C. Krishna, William Stein, William DeGraff, Angelo Russo, and James B. Mitchell
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5390–5395. Published online 2003 April 17. doi: 10.1073/pnas.0930078100.
PMCID: PMC154355
Chemically programmed monoclonal antibodies for cancer therapy: Adaptor immunotherapy based on a covalent antibody catalyst
Christoph Rader, Subhash C. Sinha, Mikhail Popkov, Richard A. Lerner, and Carlos F. Barbas, III
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5396–5400. Published online 2003 April 17. doi: 10.1073/pnas.0931308100.
PMCID: PMC154356
Cancer-related changes in prostate DNA as men age and early identification of metastasis in primary prostate tumors
Donald C. Malins, Paul M. Johnson, Edward A. Barker, Nayak L. Polissar, Thomas M. Wheeler, and Katie M. Anderson
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5401–5406. Published online 2003 April 17. doi: 10.1073/pnas.0931396100.
PMCID: PMC154357
Delivery of bioactive molecules to mitochondria in vivo
Robin A. J. Smith, Carolyn M. Porteous, Alison M. Gane, and Michael P. Murphy
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5407–5412. Published online 2003 April 15. doi: 10.1073/pnas.0931245100.
PMCID: PMC154358
Synthetic matrix metalloproteinase-sensitive hydrogels for the conduction of tissue regeneration: Engineering cell-invasion characteristics
M. P. Lutolf, J. L. Lauer-Fields, H. G. Schmoekel, A. T. Metters, F. E. Weber, G. B. Fields, and J. A. Hubbell
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5413–5418. Published online 2003 April 9. doi: 10.1073/pnas.0737381100.
PMCID: PMC154359
Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue
Bryan A. Laffitte, Lily C. Chao, Jing Li, Robert Walczak, Sarah Hummasti, Sean B. Joseph, Antonio Castrillo, Damien C. Wilpitz, David J. Mangelsdorf, Jon L. Collins, Enrique Saez, and Peter Tontonoz
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5419–5424. Published online 2003 April 15. doi: 10.1073/pnas.0830671100.
PMCID: PMC154360
Genetic changes occurring in established tumors rapidly stimulate new antibody responses
Michael T. Spiotto, Michael A. Reth, and Hans Schreiber
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5425–5430. Published online 2003 April 17. doi: 10.1073/pnas.0930140100.
PMCID: PMC154361
Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1)
Seiji Kondo, Ying Lu, Michael Debbas, Athena W. Lin, Ildiko Sarosi, Annick Itie, Andrew Wakeham, JoAnn Tuan, Chris Saris, Gary Elliott, Weili Ma, Samuel Benchimol, Scott W. Lowe, Tak Wah Mak, and Sushil K. Thukral
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5431–5436. Published online 2003 April 17. doi: 10.1073/pnas.0530308100.
PMCID: PMC154362
Microbiology
Mycobacterium tuberculosis glycosylated phosphatidylinositol causes phagosome maturation arrest
Rutilio A. Fratti, Jennifer Chua, Isabelle Vergne, and Vojo Deretic
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5437–5442. Published online 2003 April 17. doi: 10.1073/pnas.0737613100.
PMCID: PMC154363
Extracellular polysaccharides mediate pilus retraction during social motility of Myxococcus xanthus
Yinuo Li, Hong Sun, Xiaoyuan Ma, Ann Lu, Renate Lux, David Zusman, and Wenyuan Shi
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5443–5448. Published online 2003 April 18. doi: 10.1073/pnas.0836639100.
PMCID: PMC154364
A sensitive, versatile microfluidic assay for bacterial chemotaxis
Hanbin Mao, Paul S. Cremer, and Michael D. Manson
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5449–5454. Published online 2003 April 18. doi: 10.1073/pnas.0931258100.
PMCID: PMC154365
Complete genome sequence of the Q-fever pathogen Coxiella burnetii
Rekha Seshadri, Ian T. Paulsen, Jonathan A. Eisen, Timothy D. Read, Karen E. Nelson, William C. Nelson, Naomi L. Ward, Hervé Tettelin, Tanja M. Davidsen, Maureen J. Beanan, Robert T. Deboy, Sean C. Daugherty, Lauren M. Brinkac, Ramana Madupu, Robert J. Dodson, Hoda M. Khouri, Kathy H. Lee, Heather A. Carty, David Scanlan, Robert A. Heinzen, Herbert A. Thompson, James E. Samuel, Claire M. Fraser, and John F. Heidelberg
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5455–5460. Published online 2003 April 18. doi: 10.1073/pnas.0931379100.
PMCID: PMC154366
Neuroscience
Modular organization of internal models of tools in the human cerebellum
Hiroshi Imamizu, Tomoe Kuroda, Satoru Miyauchi, Toshinori Yoshioka, and Mitsuo Kawato
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5461–5466. Published online 2003 April 18. doi: 10.1073/pnas.0835746100.
PMCID: PMC154367
Subtask sequencing in the primary visual cortex
Pieter R. Roelfsema, Paul S. Khayat, and Henk Spekreijse
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5467–5472. Published online 2003 April 14. doi: 10.1073/pnas.0431051100.
PMCID: PMC154368
Cyclooxygenase-2 is instrumental in Parkinson's disease neurodegeneration
Peter Teismann, Kim Tieu, Dong-Kug Choi, Du-Chu Wu, Ali Naini, Stéphane Hunot, Miquel Vila, Vernice Jackson-Lewis, and Serge Przedborski
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5473–5478. Published online 2003 April 17. doi: 10.1073/pnas.0837397100.
PMCID: PMC154369
A reelin–integrin receptor interaction regulates Arc mRNA translation in synaptoneurosomes
Erbo Dong, Hector Caruncho, Wen Sheng Liu, Neil R. Smalheiser, Dennis R. Grayson, Erminio Costa, and Alessandro Guidotti
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5479–5484. Published online 2003 April 21. doi: 10.1073/pnas.1031602100.
PMCID: PMC154370
γ-Aminobutyric acid B receptor 1 mediates behavior-impairing actions of alcohol in Drosophila: Adult RNA interference and pharmacological evidence
Svetlana Dzitoyeva, Nikola Dimitrijevic, and Hari Manev
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5485–5490. Published online 2003 April 11. doi: 10.1073/pnas.0830111100.
PMCID: PMC154371
Analysis of gene expression in the developing mouse retina
Elva Díaz, Yee Hwa Yang, Todd Ferreira, Kenneth C. Loh, Yasushi Okazaki, Yoshihide Hayashizaki, Marc Tessier-Lavigne, Terence P. Speed, and John Ngai
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5491–5496. Published online 2003 April 17. doi: 10.1073/pnas.0831080100.
PMCID: PMC154372
Neural mechanisms of empathy in humans: A relay from neural systems for imitation to limbic areas
Laurie Carr, Marco Iacoboni, Marie-Charlotte Dubeau, John C. Mazziotta, and Gian Luigi Lenzi
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5497–5502. Published online 2003 April 7. doi: 10.1073/pnas.0935845100.
PMCID: PMC154373
N-methyl-d-aspartate receptor blockade during development lowers long-term potentiation threshold without affecting dynamic range of CA3-CA1 synapses
Nataša Savić, Andreas Lüthi, Beat H. Gähwiler, and R. Anne McKinney
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5503–5508. Published online 2003 April 17. doi: 10.1073/pnas.0831035100.
PMCID: PMC154374
Selective heteromeric assembly of cyclic nucleotide-gated channels
Haining Zhong, Jun Lai, and King-Wai Yau
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5509–5513. Published online 2003 April 16. doi: 10.1073/pnas.0931279100.
PMCID: PMC154375
Motion generation by Drosophila mechanosensory neurons
M. C. Göpfert and D. Robert
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5514–5519. Published online 2003 March 17. doi: 10.1073/pnas.0737564100.
PMCID: PMC154376
Naturalizing consciousness: A theoretical framework
Gerald M. Edelman
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5520–5524. Published online 2003 April 17. doi: 10.1073/pnas.0931349100.
PMCID: PMC154377
Pharmacology
Identification of a series of CCK-2 receptor nonpeptide agonists: Sensitivity to stereochemistry and a receptor point mutation
Alan S. Kopin, Edward W. McBride, Ci Chen, Roger M. Freidinger, Duan Chen, Chun-Mei Zhao, and Martin Beinborn
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5525–5530. Published online 2003 April 15. doi: 10.1073/pnas.0831223100.
PMCID: PMC154378
Involvement of β3-adrenergic receptor activation via cyclic GMP- but not NO-dependent mechanisms in human corpus cavernosum function
Giuseppe Cirino, Raffaella Sorrentino, Roberta d'Emmanuele di Villa Bianca, Ada Popolo, Alessandro Palmieri, Ciro Imbimbo, Ferdinando Fusco, Nicola Longo, Gianfranco Tajana, Louis J. Ignarro, and Vincenzo Mirone
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5531–5536. Published online 2003 April 21. doi: 10.1073/pnas.0931347100.
PMCID: PMC154379
From the Cover:
Positive inotropic and lusitropic effects of HNO/NO in failing hearts: Independence from β-adrenergic signaling
Nazareno Paolocci, Tatsuo Katori, Hunter C. Champion, Marcus E. St. John, Katrina M. Miranda, Jon M. Fukuto, David A. Wink, and David A. Kass
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5537–5542. Published online 2003 April 18. doi: 10.1073/pnas.0937302100.
PMCID: PMC154380
Physiology
Functional role of L-type Cav1.3 Ca2+ channels in cardiac pacemaker activity
Matteo E. Mangoni, Brigitte Couette, Emmanuel Bourinet, Josef Platzer, Daniel Reimer, Jörg Striessnig, and Joël Nargeot
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5543–5548. Published online 2003 April 16. doi: 10.1073/pnas.0935295100.
PMCID: PMC154381
Plant Biology
The Arabidopsis outward K+ channel GORK is involved in regulation of stomatal movements and plant transpiration
Eric Hosy, Alain Vavasseur, Karine Mouline, Ingo Dreyer, Frédéric Gaymard, Fabien Porée, Jossia Boucherez, Anne Lebaudy, David Bouchez, Anne-Aliénor Véry, Thierry Simonneau, Jean-Baptiste Thibaud, and Hervé Sentenac
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5549–5554. Published online 2003 April 1. doi: 10.1073/pnas.0733970100.
PMCID: PMC154382
From the Cover:
Overexpression of barley BAX inhibitor 1 induces breakdown of mlo-mediated penetration resistance to Blumeria graminis
Ralph Hückelhoven, Cornelia Dechert, and Karl-Heinz Kogel
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5555–5560. Published online 2003 April 18. doi: 10.1073/pnas.0931464100.
PMCID: PMC154383
Cell division pattern influences gene expression in the shoot apical meristem
Joanna Wyrzykowska and Andrew Fleming
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5561–5566. Published online 2003 April 17. doi: 10.1073/pnas.0930352100.
PMCID: PMC154384
Psychology
Speech–sound-selective auditory impairment in children with autism: They can perceive but do not attend
R. Čeponienė, T. Lepistö, A. Shestakova, R. Vanhala, P. Alku, R. Näätänen, and K. Yaguchi
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5567–5572. Published online 2003 April 17. doi: 10.1073/pnas.0835631100.
PMCID: PMC154385
Corrections
Correction
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5573. Published online 2003 April 9. doi: 10.1073/pnas.1030820100.
PMCID: PMC154277
Corrects: Sophie Schwartz, et al. Neural correlates of perceptual learning: A functional MRI study of visual texture discrimination. Proc Natl Acad Sci U S A. 2002 December 24; 99(26): 17137–17142.
Correction
Proc Natl Acad Sci U S A. 2003 April 29; 100(9): 5573. Published online 2003 April 10. doi: 10.1073/pnas.1031189100.
PMCID: PMC154278
Corrects: William E. Williams, et al. Surface gas-exchange processes of snow algae. Proc Natl Acad Sci U S A. 2003 January 21; 100(2): 562–566.
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