| | This journal provides immediate access to some articles. Commentaries Unraveling the secrets of Alzheimer's β-amyloid fibrils Lynmarie K. Thompson PMCID: PMC141002 From a pump to a pore: How palytoxin opens the gates Donald W. Hilgemann PMCID: PMC141003 Physical Sciences Applied Physical Sciences Rare earth-doped glass microbarcodes Matthew J. Dejneka, Alexander Streltsov, Santona Pal, Anthony G. Frutos, Christy L. Powell, Kevin Yost, Po Ki Yuen, Uwe Müller, and Joydeep Lahiri PMCID: PMC141004 Chemistry Self-consistent determination of the transition state for protein folding: Application to a fibronectin type III domain Emanuele Paci, Jane Clarke, Annette Steward, Michele Vendruscolo, and Martin Karplus PMCID: PMC141005 Artificial cells: Unique insights into exocytosis using liposomes and lipid nanotubes Ann-Sofie Cans, Nathan Wittenberg, Roger Karlsson, Leslie Sombers, Mattias Karlsson, Owe Orwar, and Andrew Ewing PMCID: PMC141006 Room temperature measurements of the 3D orientation of single CdSe quantum dots using polarization microscopy Inhee Chung, Ken T. Shimizu, and Moungi G. Bawendi PMCID: PMC141007 From the Cover:
Photocleavage of a 2-nitrobenzyl linker bridging a fluorophore to the 5′ end of DNA Xiaopeng Bai, Zengmin Li, Steffen Jockusch, Nicholas J. Turro, and Jingyue Ju PMCID: PMC141008 A photocleavable fluorescent nucleotide for DNA sequencing and analysis Zengmin Li, Xiaopeng Bai, Hameer Ruparel, Sobin Kim, Nicholas J. Turro, and Jingyue Ju PMCID: PMC141009 Engineering From the Cover:
Nondiffusive mechanisms enhance protein uptake rates in ion exchange particles S. R. Dziennik, E. B. Belcher, G. A. Barker, M. J. DeBergalis, S. E. Fernandez, and A. M. Lenhoff PMCID: PMC141010 Mathematics The Euler–Maclaurin formula for simple integral polytopes Yael Karshon, Shlomo Sternberg, and Jonathan Weitsman PMCID: PMC141011 Hilbert series, Howe duality, and branching rules Thomas J. Enright and Jeb F. Willenbring PMCID: PMC141012 Biological Sciences Applied Biological Sciences Expression and assembly of a fully active antibody in algae Stephen P. Mayfield, Scott E. Franklin, and Richard A. Lerner PMCID: PMC141013 Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry Arthur R. Salomon, Scott B. Ficarro, Laurence M. Brill, Achim Brinker, Qui T. Phung, Christer Ericson, Karsten Sauer, Ansgar Brock, David M. Horn, Peter G. Schultz, and Eric C. Peters PMCID: PMC141014 Biochemistry Rare earth-doped glass microbarcodes Matthew J. Dejneka, Alexander Streltsov, Santona Pal, Anthony G. Frutos, Christy L. Powell, Kevin Yost, Po Ki Yuen, Uwe Müller, and Joydeep Lahiri PMCID: PMC141004 Mutations linked to dyskeratosis congenita cause changes in the structural equilibrium in telomerase RNA Carla A. Theimer, L. David Finger, Lukas Trantirek, and Juli Feigon PMCID: PMC141015 Directed evolution approach to a structural genomics project: Rv2002 from Mycobacterium tuberculosis Jin Kuk Yang, Min S. Park, Geoffrey S. Waldo, and Se Won Suh PMCID: PMC141016 Routes to S-nitroso-hemoglobin formation with heme redox and preferential reactivity in the β subunits Benjamin P. Luchsinger, Eric N. Rich, Andrew J. Gow, Elizabeth M. Williams, Jonathan S. Stamler, and David J. Singel PMCID: PMC141017 INAUGURAL ARTICLE by a Recently Elected Academy Member: Modeling of the inhibitory interaction of phospholamban with the Ca 2+ ATPase Chikashi Toyoshima, Michio Asahi, Yuji Sugita, Reena Khanna, Takeo Tsuda, and David H. MacLennan PMCID: PMC141018 Atpenins, potent and specific inhibitors of mitochondrial complex II (succinate-ubiquinone oxidoreductase) Hiroko Miyadera, Kazuro Shiomi, Hideaki Ui, Yuichi Yamaguchi, Rokuro Masuma, Hiroshi Tomoda, Hideto Miyoshi, Arihiro Osanai, Kiyoshi Kita, and Satoshi Ōmura PMCID: PMC141019 Visualization of coupled protein folding and binding in bacteria and purification of the heterodimeric complex Haoyong Wang and Shaorong Chong PMCID: PMC141020 The binding specificity and affinity determinants of family 1 and family 3 cellulose binding modules Janne Lehtiö, Junji Sugiyama, Malin Gustavsson, Linda Fransson, Markus Linder, and Tuula T. Teeri PMCID: PMC141021 Interstice mutations that block site-to-site translocation of a misactivated amino acid bound to a class I tRNA synthetase Anthony C. Bishop, Kirk Beebe, and Paul R. Schimmel PMCID: PMC141022 Biophysics From the Cover:
Photocleavage of a 2-nitrobenzyl linker bridging a fluorophore to the 5′ end of DNA Xiaopeng Bai, Zengmin Li, Steffen Jockusch, Nicholas J. Turro, and Jingyue Ju PMCID: PMC141008 A photocleavable fluorescent nucleotide for DNA sequencing and analysis Zengmin Li, Xiaopeng Bai, Hameer Ruparel, Sobin Kim, Nicholas J. Turro, and Jingyue Ju PMCID: PMC141009 From the Cover:
Nondiffusive mechanisms enhance protein uptake rates in ion exchange particles S. R. Dziennik, E. B. Belcher, G. A. Barker, M. J. DeBergalis, S. E. Fernandez, and A. M. Lenhoff PMCID: PMC141010 Assembly of single chromatin fibers depends on the tension in the DNA molecule: Magnetic tweezers study Sanford H. Leuba, Mikhail A. Karymov, Miroslav Tomschik, Ravi Ramjit, Paul Smith, and Jordanka Zlatanova PMCID: PMC141023 From the Cover:
Na+/K+-pump ligands modulate gating of palytoxin-induced ion channels Pablo Artigas and David C. Gadsby PMCID: PMC141024 Optimal ion channel clustering for intracellular calcium signaling J. W. Shuai and P. Jung PMCID: PMC141025 Identification of a PU.1–IRF4 protein interaction surface predicted by chemical exchange line broadening Scott R. McKercher, Christian R. Lombardo, Andrey Bobkov, Xin Jia, and Nuria Assa-Munt PMCID: PMC141026 Quaternary structure of hemoglobin in solution Jonathan A. Lukin, Georg Kontaxis, Virgil Simplaceanu, Yue Yuan, Ad Bax, and Chien Ho PMCID: PMC141027 Cell Biology CEACAM1-4S, a cell–cell adhesion molecule, mediates apoptosis and reverts mammary carcinoma cells to a normal morphogenic phenotype in a 3D culture Julia Kirshner, Charng-Jui Chen, Pingfang Liu, Jie Huang, and John E. Shively PMCID: PMC141028 Evidence that exposure of the telomere 3′ overhang sequence induces senescence Guang-Zhi Li, Mark S. Eller, Reza Firoozabadi, and Barbara A. Gilchrest PMCID: PMC141029 Developmental Biology Induction of neural crest in Xenopus by transcription factor AP2α Ting Luo, Young-Hoon Lee, Jean-Pierre Saint-Jeannet, and Thomas D. Sargent PMCID: PMC141030 Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-Like proteins Frederick L. Moore, Jadwiga Jaruzelska, Mark S. Fox, Jun Urano, Meri T. Firpo, Paul J. Turek, David M. Dorfman, and Renee A. Reijo Pera PMCID: PMC141031 Cyclicity of mosquito vitellogenic ecdysteroid-mediated signaling is modulated by alternative dimerization of the RXR homologue Ultraspiracle Jinsong Zhu, Ken Miura, Li Chen, and Alexander S. Raikhel PMCID: PMC141032 RFPL4 interacts with oocyte proteins of the ubiquitin-proteasome degradation pathway Nobuhiro Suzumori, Kathleen H. Burns, Wei Yan, and Martin M. Matzuk PMCID: PMC141033 Impaired B cell development and function in mice with a targeted disruption of the homeobox gene Hex Clifford W. Bogue, Ping-Xia Zhang, James McGrath, Harris C. Jacobs, and Ramsay L. Fuleihan PMCID: PMC141034 Ecology Surface gas-exchange processes of snow algae William E. Williams, Holly L. Gorton, and Thomas C. Vogelmann PMCID: PMC141035 From the Cover:
The ecology of infectious disease: Effects of host diversity and community composition on Lyme disease risk Kathleen LoGiudice, Richard S. Ostfeld, Kenneth A. Schmidt, and Felicia Keesing PMCID: PMC141036 Cloud cover limits net CO2 uptake and growth of a rainforest tree during tropical rainy seasons Eric A. Graham, Stephen S. Mulkey, Kaoru Kitajima, Nathan G. Phillips, and S. Joseph Wright PMCID: PMC141037 Bimodal signal requisite for agonistic behavior in a dart-poison frog, Epipedobates femoralis Peter M. Narins, Walter Hödl, and Daniela S. Grabul PMCID: PMC141038 Evolution Reductive genome evolution in Buchnera aphidicola Roeland C. H. J. van Ham, Judith Kamerbeek, Carmen Palacios, Carolina Rausell, Federico Abascal, Ugo Bastolla, Jose M. Fernández, Luis Jiménez, Marina Postigo, Francisco J. Silva, Javier Tamames, Enrique Viguera, Amparo Latorre, Alfonso Valencia, Federico Morán, and Andrés Moya PMCID: PMC141039 The solitary wave of asexual evolution Igor M. Rouzine, John Wakeley, and John M. Coffin PMCID: PMC141040 The Red King effect: When the slowest runner wins the coevolutionary race Carl T. Bergstrom and Michael Lachmann PMCID: PMC141041 Correlated terrestrial and marine evidence for global climate changes before mass extinction at the Cretaceous–Paleogene boundary Peter Wilf, Kirk R. Johnson, and Brian T. Huber PMCID: PMC141042 Genetics From the Cover:
Identification of a gene causing human cytochrome c oxidase deficiency by integrative genomics Vamsi K. Mootha, Pierre Lepage, Kathleen Miller, Jakob Bunkenborg, Michael Reich, Majbrit Hjerrild, Terrye Delmonte, Amelie Villeneuve, Robert Sladek, Fenghao Xu, Grant A. Mitchell, Charles Morin, Matthias Mann, Thomas J. Hudson, Brian Robinson, John D. Rioux, and Eric S. Lander PMCID: PMC141043 Ku is required for telomeric C-rich strand maintenance but not for end-to-end chromosome fusions in Arabidopsis Karel Riha and Dorothy E. Shippen PMCID: PMC141044 Global genome repair is required to activate KIN17, a UVC-responsive gene involved in DNA replication Christel Masson, Farid Menaa, Ghislaine Pinon-Lataillade, Yveline Frobert, Sylvie Chevillard, J. Pablo Radicella, Alain Sarasin, and Jaime F. Angulo PMCID: PMC141045 Immunology Urochordates and the origin of natural killer cells: Identification of a CD94/NKR-P1-related receptor in blood cells of Botryllus Konstantin Khalturin, Matthias Becker, Baruch Rinkevich, and Thomas C. G. Bosch PMCID: PMC141046 Contribution of Fas to diabetes development Alexei Y. Savinov, Andrew Tcherepanov, E. Allison Green, Richard A. Flavell, and Alexander V. Chervonsky PMCID: PMC141047 CTCF functions as a critical regulator of cell-cycle arrest and death after ligation of the B cell receptor on immature B cells Chen-Feng Qi, Annica Martensson, Michela Mattioli, Riccardo Dalla-Favera, Victor V. Lobanenkov, and Herbert C. Morse, III PMCID: PMC141048 Medical Sciences A monoclonal antibody recognizing human cancers with amplification/overexpression of the human epidermal growth factor receptor Achim A. Jungbluth, Elisabeth Stockert, H. J. Su Huang, Vincent P. Collins, Keren Coplan, Kristin Iversen, Denise Kolb, Terrance J. Johns, Andrew M. Scott, William J. Gullick, Gerd Ritter, Leonard Cohen, Matthew J. Scanlan, Webster K. Cavanee, and Lloyd J. Old PMCID: PMC141049 High-efficiency recovery of functional hematopoietic progenitor and stem cells from human cord blood cryopreserved for 15 years Hal E. Broxmeyer, Edward F. Srour, Giao Hangoc, Scott Cooper, Stacie A. Anderson, and David M. Bodine PMCID: PMC141050 Rational design of low-molecular weight heparins with improved in vivo activity Mallik Sundaram, Yiwei Qi, Zachary Shriver, Dongfang Liu, Ganlin Zhao, Ganesh Venkataraman, Robert Langer, and Ram Sasisekharan PMCID: PMC141051 Potent antitumor activity of a urokinase-activated engineered anthrax toxin Shihui Liu, Hannah Aaronson, David J. Mitola, Stephen H. Leppla, and Thomas H. Bugge PMCID: PMC141052 WNK1, a kinase mutated in inherited hypertension with hyperkalemia, localizes to diverse Cl−-transporting epithelia Keith A. Choate, Kristopher T. Kahle, Frederick H. Wilson, Carol Nelson-Williams, and Richard P. Lifton PMCID: PMC141053 Dual roles of modulatory calcineurin-interacting protein 1 in cardiac hypertrophy Rick B. Vega, Beverly A. Rothermel, Carla J. Weinheimer, Atilla Kovacs, R. H. Naseem, Rhonda Bassel-Duby, R. S. Williams, and Eric N. Olson PMCID: PMC141054 Unique inflammatory RNA profiles of microglia in Creutzfeldt–Jakob disease Christopher A. Baker and Laura Manuelidis PMCID: PMC141055 Molecular pathogenesis of inherited hypertension with hyperkalemia: The Na–Cl cotransporter is inhibited by wild-type but not mutant WNK4 Frederick H. Wilson, Kristopher T. Kahle, Ernesto Sabath, Maria D. Lalioti, Alicia K. Rapson, Robert S. Hoover, Steven C. Hebert, Gerardo Gamba, and Richard P. Lifton PMCID: PMC141056 Microbiology 8-Nitroguanosine formation in viral pneumonia and its implication for pathogenesis Takaaki Akaike, Shinichiro Okamoto, Tomohiro Sawa, Jun Yoshitake, Fumio Tamura, Koji Ichimori, Kiminori Miyazaki, Kazumi Sasamoto, and Hiroshi Maeda PMCID: PMC141057 Robustness and the cycle of phosphorylation and dephosphorylation in a two-component regulatory system Eric Batchelor and Mark Goulian PMCID: PMC141058 Autochthonous eukaryotic diversity in hydrothermal sediment and experimental microcolonizers at the Mid-Atlantic Ridge Purificación López-García, Hervé Philippe, Françoise Gail, and David Moreira PMCID: PMC141059 Neuroscience Artificial cells: Unique insights into exocytosis using liposomes and lipid nanotubes Ann-Sofie Cans, Nathan Wittenberg, Roger Karlsson, Leslie Sombers, Mattias Karlsson, Owe Orwar, and Andrew Ewing PMCID: PMC141006 Estrogen receptor (ER)β knockout mice reveal a role for ERβ in migration of cortical neurons in the developing brain Ling Wang, Sandra Andersson, Margaret Warner, and Jan-Åke Gustafsson PMCID: PMC141060 Exclusive tumor necrosis factor (TNF) signaling by the p75TNF receptor triggers inflammatory ischemia in the CNS of transgenic mice Katerina Akassoglou, Eleni Douni, Jan Bauer, Hans Lassmann, George Kollias, and Lesley Probert PMCID: PMC141061 Caspase 3 activation is essential for neuroprotection in preconditioning BethAnn McLaughlin, Karen A. Hartnett, Joseph A. Erhardt, Jeffrey J. Legos, Ray F. White, Frank C. Barone, and Elias Aizenman PMCID: PMC141062 Chaperones increase association of tau protein with microtubules Fei Dou, William J. Netzer, Kentaro Tanemura, Feng Li, F. Ulrich Hartl, Akihiko Takashima, Gunnar K. Gouras, Paul Greengard, and Huaxi Xu PMCID: PMC141063 Permissive corridor and diffusible gradients direct medial ganglionic eminence cell migration to the neocortex Hynek Wichterle, Manuel Alvarez-Dolado, Lynda Erskine, and Arturo Alvarez-Buylla PMCID: PMC141064 Pharmacology Gα12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF Nobuchika Suzuki, Susumu Nakamura, Hiroyuki Mano, and Tohru Kozasa PMCID: PMC141065 Sexual dimorphism in reduced-size liver ischemia and reperfusion injury in mice: Role of endothelial cell nitric oxide synthase Hirohisa Harada, Kevin P. Pavlick, Ian N. Hines, David J. Lefer, Jason M. Hoffman, Sulaiman Bharwani, Robert E. Wolf, and Matthew B. Grisham PMCID: PMC141066 Physiology Specificity of activation by phosphoinositides determines lipid regulation of Kir channels Tibor Rohács, Coeli M. B. Lopes, Taihao Jin, Pavan P. Ramdya, Zoltán Molnár, and Diomedes E. Logothetis PMCID: PMC141067 Plant Biology Involvement of CjMDR1, a plant multidrug-resistance-type ATP-binding cassette protein, in alkaloid transport in Coptis japonica Nobukazu Shitan, Ingrid Bazin, Kazuyuki Dan, Kazuaki Obata, Koji Kigawa, Kazumitsu Ueda, Fumihiko Sato, Cyrille Forestier, and Kazufumi Yazaki PMCID: PMC141068 A novel plant protein undergoing light-induced phosphorylation and release from the photosynthetic thylakoid membranes Inger Carlberg, Maria Hansson, Thomas Kieselbach, Wolfgang P. Schröder, Bertil Andersson, and Alexander V. Vener PMCID: PMC141069 Corrections Proc Natl Acad Sci U S A. 2003 January 21; 100(2): 763. Published online 2003 January 6. doi: 10.1073/pnas.0337430100.PMCID: PMC140996 Corrects: Imed-Eddine Gallouzi, et al. HuR binding to cytoplasmic mRNA is perturbed by heat shock. Proc Natl Acad Sci U S A. 2000 March 28; 97(7): 3073–3078. Proc Natl Acad Sci U S A. 2003 January 21; 100(2): 763. Published online 2003 January 2. doi: 10.1073/pnas.0337360100.PMCID: PMC140997 Corrects: Stanly B. Williams, et al. Structure and function from the circadian clock protein KaiA of Synechococcus elongatus: A potential clock input mechanism. Proc Natl Acad Sci U S A. 2002 November 26; 99(24): 15357–15362. Proc Natl Acad Sci U S A. 2003 January 21; 100(2): 763. Published online 2003 January 6. doi: 10.1073/pnas.0337129100.PMCID: PMC140998 Corrects: Ian Reeve, et al. Overexpression, purification, and site-directed spin labeling of the Nramp metal transporter from Mycobacterium leprae. Proc Natl Acad Sci U S A. 2002 June 25; 99(13): 8608–8613. Proc Natl Acad Sci U S A. 2003 January 21; 100(2): 763. Published online 2003 January 2. doi: 10.1073/pnas.0337131100.PMCID: PMC140999 Corrects: Helen Vlassara, et al. Inflammatory mediators are induced by dietary glycotoxins, a major risk factor for diabetic angiopathy. Proc Natl Acad Sci U S A. 2002 November 26; 99(24): 15596–15601. Proc Natl Acad Sci U S A. 2003 January 21; 100(2): 763. Published online 2003 January 2. doi: 10.1073/pnas.0337132100.PMCID: PMC141000 Corrects: Xiaowei Niu, et al. Stepwise contribution of each subunit to the cooperative activation of BK channels by Ca2+. Proc Natl Acad Sci U S A. 2002 August 20; 99(17): 11441–11446. Proc Natl Acad Sci U S A. 2003 January 21; 100(2): 763. Published online 2003 January 6. doi: 10.1073/pnas.0337361100..PMCID: PMC141001 Corrects: Edwin D. Kilbourne, et al. The total influenza vaccine failure of 1947 revisited: Major intrasubtypic antigenic change can explain failure of vaccine in a post-World War II epidemic. Proc Natl Acad Sci U S A. 2002 August 6; 99(16): 10748–10752. |
