| | This journal provides immediate access to some articles. Letters Hibernation can also cause high δ15N values in cave bears: A response to Richards et al. Aurora Grandal d'Anglade and Daniel Fernández Mosquera PMCID: PMC2393754 Reply to Grandal and Fernández: Hibernation can also cause high δ15N values in cave bears Erik Trinkaus and Michael P. Richards PMCID: PMC2393794 This Week in PNAS Proc Natl Acad Sci U S A. 2008 March 18; 105(11): 4075–4076. doi: 10.1073/iti1108105.PMCID: PMC2393801 Commentaries Holocene underkill Donald K. Grayson PMCID: PMC2393799 The “Goldilocks factor” in food webs Eric L. Berlow, Ulrich Brose, and Neo D. Martinez PMCID: PMC2393745 Making autoantibodies safe Christopher N. Scanlan, Dennis R. Burton, and Raymond A. Dwek PMCID: PMC2393817 Physical Sciences Applied Physical Sciences A simple and exact Laplacian clustering of complex networking phenomena: Application to gene expression profiles Choongrak Kim, Mookyung Cheon, Minho Kang, and Iksoo Chang PMCID: PMC2393820 Chemistry The dual mode of action of bistramide A entails severing of filamentous actin and covalent protein modification Syed Alipayam Rizvi, David S. Courson, Valerie A. Keller, Ronald S. Rock, and Sergey A. Kozmin PMCID: PMC2393769 Mass spectrometry identifies and quantifies 74 unique histone H4 isoforms in differentiating human embryonic stem cells Doug Phanstiel, Justin Brumbaugh, W. Travis Berggren, Kevin Conard, Xuezhu Feng, Mark E. Levenstein, Graeme C. McAlister, James A. Thomson, and Joshua J. Coon PMCID: PMC2393763 Controlling the rates of biochemical reactions and signaling networks by shape and volume changes L. Lizana, B. Bauer, and O. Orwar PMCID: PMC2393822 A disulfide-stabilized conformer of methionine synthase reveals an unexpected role for the histidine ligand of the cobalamin cofactor Supratim Datta, Markos Koutmos, Katherine A. Pattridge, Martha L. Ludwig, and Rowena G. Matthews PMCID: PMC2393809 Biological Sciences Biochemistry The dual mode of action of bistramide A entails severing of filamentous actin and covalent protein modification Syed Alipayam Rizvi, David S. Courson, Valerie A. Keller, Ronald S. Rock, and Sergey A. Kozmin PMCID: PMC2393769 Mass spectrometry identifies and quantifies 74 unique histone H4 isoforms in differentiating human embryonic stem cells Doug Phanstiel, Justin Brumbaugh, W. Travis Berggren, Kevin Conard, Xuezhu Feng, Mark E. Levenstein, Graeme C. McAlister, James A. Thomson, and Joshua J. Coon PMCID: PMC2393763 A disulfide-stabilized conformer of methionine synthase reveals an unexpected role for the histidine ligand of the cobalamin cofactor Supratim Datta, Markos Koutmos, Katherine A. Pattridge, Martha L. Ludwig, and Rowena G. Matthews PMCID: PMC2393809 Crystal structure of the [2Fe-2S] oxidative-stress sensor SoxR bound to DNA Satoshi Watanabe, Akiko Kita, Kazuo Kobayashi, and Kunio Miki PMCID: PMC2393793 Contribution of positively charged flanking residues to the insertion of transmembrane helices into the endoplasmic reticulum Mirjam Lerch-Bader, Carolina Lundin, Hyun Kim, IngMarie Nilsson, and Gunnar von Heijne PMCID: PMC2393759 Confinement of caspase-12 proteolytic activity to autoprocessing Sophie Roy, Jeffrey R. Sharom, Caroline Houde, Thomas P. Loisel, John P. Vaillancourt, Wei Shao, Maya Saleh, and Donald W. Nicholson PMCID: PMC2393782 Biophysics Comparing bird and human soaring strategies Zsuzsa Ákos, Máté Nagy, and Tamás Vicsek PMCID: PMC2393768 Structural inference of native and partially folded RNA by high-throughput contact mapping Rhiju Das, Madhuri Kudaravalli, Magdalena Jonikas, Alain Laederach, Robert Fong, Jason P. Schwans, David Baker, Joseph A. Piccirilli, Russ B. Altman, and Daniel Herschlag PMCID: PMC2393762 Manipulation of the mechanical properties of a virus by protein engineering Carolina Carrasco, Milagros Castellanos, Pedro J. de Pablo, and Mauricio G. Mateu PMCID: PMC2393779 Fluorescence resonance energy transfer in near-infrared fluorescent oligonucleotide probes for detecting protein–DNA interactions Surong Zhang, Valeri Metelev, David Tabatadze, Paul C. Zamecnik, and Alexei Bogdanov, Jr PMCID: PMC2393815 Cell Biology Isoform-specific monoubiquitination, endocytosis, and degradation of alternatively spliced ErbB4 isoforms Maria Sundvall, Anna Korhonen, Ilkka Paatero, Eugenio Gaudio, Gerry Melino, Carlo M. Croce, Rami I. Aqeilan, and Klaus Elenius PMCID: PMC2393780 Specific requirement of the chromatin modifier mSin3B in cell cycle exit and cellular differentiation Gregory David, Kathryn B. Grandinetti, Patricia M. Finnerty, Natalie Simpson, Gerald C. Chu, and Ronald A. DePinho PMCID: PMC2393767 NFAR-1 and -2 modulate translation and are required for efficient host defense Ingrid Pfeifer, Rachel Elsby, Marilyn Fernandez, Paula A. Faria, Daniel R. Nussenzveig, Izidor S. Lossos, Beatriz M. A. Fontoura, W. David Martin, and Glen N. Barber PMCID: PMC2393807 Histone deacetylase 3 localizes to the mitotic spindle and is required for kinetochore–microtubule attachment Sumiyasu Ishii, Yasuhiro Kurasawa, Jiemin Wong, and Li-yuan Yu-Lee PMCID: PMC2393771 Developmental Biology Unique SMAD1/5/8 activity at the phalanx-forming region determines digit identity Takayuki Suzuki, Sean M. Hasso, and John F. Fallon PMCID: PMC2393776 Ecology From the Cover:
Size, foraging, and food web structure Owen L. Petchey, Andrew P. Beckerman, Jens O. Riede, and Philip H. Warren PMCID: PMC2393804 A rapid upward shift of a forest ecotone during 40 years of warming in the Green Mountains of Vermont Brian Beckage, Ben Osborne, Daniel G. Gavin, Carolyn Pucko, Thomas Siccama, and Timothy Perkins PMCID: PMC2393766 Heat stress causes inhibition of the de novo synthesis of antenna proteins and photobleaching in cultured Symbiodinium Shunichi Takahashi, Spencer Whitney, Shigeru Itoh, Tadashi Maruyama, and Murray Badger PMCID: PMC2393757 Environmental Sciences Rapid chemotactic response enables marine bacteria to exploit ephemeral microscale nutrient patches Roman Stocker, Justin R. Seymour, Azadeh Samadani, Dana E. Hunt, and Martin F. Polz PMCID: PMC2393791 Evolution From the Cover:
Active tails enhance arboreal acrobatics in geckos Ardian Jusufi, Daniel I. Goldman, Shai Revzen, and Robert J. Full PMCID: PMC2393739 Possible involvement of SINEs in mammalian-specific brain formation Takeshi Sasaki, Hidenori Nishihara, Mika Hirakawa, Koji Fujimura, Mikiko Tanaka, Nobuhiro Kokubo, Chiharu Kimura-Yoshida, Isao Matsuo, Kenta Sumiyama, Naruya Saitou, Tomomi Shimogori, and Norihiro Okada PMCID: PMC2393765 Insulin signaling is involved in the regulation of worker division of labor in honey bee colonies Seth A. Ament, Miguel Corona, Henry S. Pollock, and Gene E. Robinson PMCID: PMC2393790 Genetics Mutations in the very low-density lipoprotein receptor VLDLR cause cerebellar hypoplasia and quadrupedal locomotion in humans Tayfun Ozcelik, Nurten Akarsu, Elif Uz, Safak Caglayan, Suleyman Gulsuner, Onur Emre Onat, Meliha Tan, and Uner Tan PMCID: PMC2393756 A mitotic recombination system for mouse chromosome 17 Lei Sun, Xiaohui Wu, Min Han, Tian Xu, and Yuan Zhuang PMCID: PMC2393783 Bardet–Biedl syndrome proteins are required for the localization of G protein-coupled receptors to primary cilia Nicolas F. Berbari, Jacqueline S. Lewis, Georgia A. Bishop, Candice C. Askwith, and Kirk Mykytyn PMCID: PMC2393805 Distinct effects of the recurrent Mlh1G67R mutation on MMR functions, cancer, and meiosis Elena Avdievich, Cora Reiss, Stefan J. Scherer, Yongwei Zhang, Sandra M. Maier, Bo Jin, Harry Hou, Jr, Andreas Rosenwald, Hubertus Riedmiller, Raju Kucherlapati, Paula E. Cohen, Winfried Edelmann, and Burkhard Kneitz PMCID: PMC2393764 Genomic imprinting effects on adult body composition in mice James M. Cheverud, Reinmar Hager, Charles Roseman, Gloria Fawcett, Bing Wang, and Jason B. Wolf PMCID: PMC2393747 Immunology Bystander B cells rapidly acquire antigen receptors from activated B cells by membrane transfer Ben J. C. Quah, Vaughan P. Barlow, Virginia McPhun, Klaus I. Matthaei, Mark D. Hulett, and Christopher R. Parish PMCID: PMC2393802 Medical Sciences From the Cover:
IgG glycan hydrolysis by a bacterial enzyme as a therapy against autoimmune conditions Mattias Collin, Oonagh Shannon, and Lars Björck PMCID: PMC2393778 PPARδ regulates multiple proinflammatory pathways to suppress atherosclerosis Grant D. Barish, Annette R. Atkins, Michael Downes, Peter Olson, Ling-Wa Chong, Mike Nelson, Yuhua Zou, Hoosang Hwang, Heonjoong Kang, Linda Curtiss, Ronald M. Evans, and Chih-Hao Lee PMCID: PMC2393796 PPARδ-mediated antiinflammatory mechanisms inhibit angiotensin II-accelerated atherosclerosis Yasunori Takata, Joey Liu, Fen Yin, Alan R. Collins, Christopher J. Lyon, Chih-Hao Lee, Annette R. Atkins, Michael Downes, Grant D. Barish, Ronald M. Evans, Willa A. Hsueh, and Rajendra K. Tangirala PMCID: PMC2393800 Comparative lesion sequencing provides insights into tumor evolution Siân Jones, Wei-dong Chen, Giovanni Parmigiani, Frank Diehl, Niko Beerenwinkel, Tibor Antal, Arne Traulsen, Martin A. Nowak, Christopher Siegel, Victor E. Velculescu, Kenneth W. Kinzler, Bert Vogelstein, Joseph Willis, and Sanford D. Markowitz PMCID: PMC2393770 Intermittent recombinant TSH injections prevent ovariectomy-induced bone loss Li Sun, Slobodan Vukicevic, Ramkumarie Baliram, Guozhe Yang, Rebecca Sendak, John McPherson, Ling-Ling Zhu, Jameel Iqbal, Rauf Latif, Arjun Natrajan, Ario Arabi, Kosj Yamoah, Baljit S. Moonga, Yankel Gabet, Terry F. Davies, Itai Bab, Etsuko Abe, Kuber Sampath, and Mone Zaidi PMCID: PMC2393772 Acetylcholinesterase inhibitors and Gulf War illnesses Beatrice Alexandra Golomb PMCID: PMC2393741 Correctly folded Pfs48/45 protein of Plasmodium falciparum elicits malaria transmission-blocking immunity in mice Nikolay S. Outchkourov, Will Roeffen, Anita Kaan, Josephine Jansen, Adrian Luty, Danielle Schuiffel, Geert Jan van Gemert, Marga van de Vegte-Bolmer, Robert W. Sauerwein, and Hendrik G. Stunnenberg PMCID: PMC2393789 Mutational load distribution analysis yields metrics reflecting genetic instability during pancreatic carcinogenesis Gemma Tarafa, David Tuck, Daniela Ladner, Mark Topazian, Randall Brand, Carolyn Deters, Victor Moreno, Gabriel Capella, Henry Lynch, Paul Lizardi, and Jose Costa PMCID: PMC2393774 Anthrax lethal toxin and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mechanisms Susan L. Fink, Tessa Bergsbaken, and Brad T. Cookson PMCID: PMC2393760 Long-term enhancement of skeletal muscle mass and strength by single gene administration of myostatin inhibitors Amanda M. Haidet, Liza Rizo, Chalonda Handy, Priya Umapathi, Amy Eagle, Chris Shilling, Daniel Boue, Paul T. Martin, Zarife Sahenk, Jerry R. Mendell, and Brian K. Kaspar PMCID: PMC2393740 Network properties of genes harboring inherited disease mutations Igor Feldman, Andrey Rzhetsky, and Dennis Vitkup PMCID: PMC2393821 Human embryonic stem cell microenvironment suppresses the tumorigenic phenotype of aggressive cancer cells Lynne-Marie Postovit, Naira V. Margaryan, Elisabeth A. Seftor, Dawn A. Kirschmann, Alina Lipavsky, William W. Wheaton, Daniel E. Abbott, Richard E. B. Seftor, and Mary J. C. Hendrix PMCID: PMC2393795 Profound functional and signaling changes in viable inflammatory neutrophils homing to cystic fibrosis airways Rabindra Tirouvanziam, Yael Gernez, Carol K. Conrad, Richard B. Moss, Iris Schrijver, Colleen E. Dunn, Zoe A. Davies, Leonore A. Herzenberg, and Leonard A. Herzenberg PMCID: PMC2393742 Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33 Bert Gold, Tomas Kirchhoff, Stefan Stefanov, James Lautenberger, Agnes Viale, Judy Garber, Eitan Friedman, Steven Narod, Adam B. Olshen, Peter Gregersen, Kristi Kosarin, Adam Olsh, Julie Bergeron, Nathan A. Ellis, Robert J. Klein, Andrew G. Clark, Larry Norton, Michael Dean, Jeff Boyd, and Kenneth Offit PMCID: PMC2393811 Microbiology Phenylalanine-427 of anthrax protective antigen functions in both pore formation and protein translocation Jianjun Sun, Alexander E. Lang, Klaus Aktories, and R. John Collier PMCID: PMC2393744 p72 DEAD box RNA helicase is required for optimal function of the zinc-finger antiviral protein Guifang Chen, Xuemin Guo, Fengxiang Lv, Yihui Xu, and Guangxia Gao PMCID: PMC2393818 Helicobacter pylori evolution during progression from chronic atrophic gastritis to gastric cancer and its impact on gastric stem cells Marios Giannakis, Swaine L. Chen, Sherif M. Karam, Lars Engstrand, and Jeffrey I. Gordon PMCID: PMC2393758 Production and sequence validation of a complete full length ORF collection for the pathogenic bacterium Vibrio cholerae Andreas Rolfs, Wagner R. Montor, Sang Sun Yoon, Yanhui Hu, Bhupinder Bhullar, Fontina Kelley, Seamus McCarron, Daniel A. Jepson, Binghua Shen, Elena Taycher, Stephanie E. Mohr, Dongmei Zuo, Janice Williamson, John Mekalanos, and Joshua LaBaer PMCID: PMC2393773 Advantages of a single-cycle production assay to study cell culture-adaptive mutations of hepatitis C virus Rodney S. Russell, Jean-Christophe Meunier, Shingo Takikawa, Kristina Faulk, Ronald E. Engle, Jens Bukh, Robert H. Purcell, and Suzanne U. Emerson PMCID: PMC2393785 Mycobacterial persistence requires the utilization of host cholesterol Amit K. Pandey and Christopher M. Sassetti PMCID: PMC2393810 A new influenza virus virulence determinant: The NS1 protein four C-terminal residues modulate pathogenicity David Jackson, Md. Jaber Hossain, Danielle Hickman, Daniel R. Perez, and Robert A. Lamb PMCID: PMC2393797 A trispecies Aspergillus microarray: Comparative transcriptomics of three Aspergillus species Mikael R. Andersen, Wanwipa Vongsangnak, Gianni Panagiotou, Margarita P. Salazar, Linda Lehmann, and Jens Nielsen PMCID: PMC2393752 Bet-hedging and epigenetic inheritance in bacterial cell development Jan-Willem Veening, Eric J. Stewart, Thomas W. Berngruber, François Taddei, Oscar P. Kuipers, and Leendert W. Hamoen PMCID: PMC2393751 Neuroscience A human intracranial study of long-range oscillatory coherence across a frontal–occipital–hippocampal brain network during visual object processing Pejman Sehatpour, Sophie Molholm, Theodore H. Schwartz, Jeannette R. Mahoney, Ashesh D. Mehta, Daniel C. Javitt, Patric K. Stanton, and John J. Foxe PMCID: PMC2393806 Increased amphetamine-induced hyperactivity and reward in mice overexpressing the dopamine transporter Ali Salahpour, Amy J. Ramsey, Ivan O. Medvedev, Brian Kile, Tatyana D. Sotnikova, Ericka Holmstrand, Valentina Ghisi, Peter J. Nicholls, Ling Wong, Karen Murphy, Susan R. Sesack, R. Mark Wightman, Raul R. Gainetdinov, and Marc G. Caron PMCID: PMC2393812 Optical measurement of synaptic glutamate spillover and reuptake by linker optimized glutamate-sensitive fluorescent reporters Samuel Andrew Hires, Yongling Zhu, and Roger Y. Tsien PMCID: PMC2393813 Temporal compression mediated by short-term synaptic plasticity Christian Leibold, Anja Gundlfinger, Robert Schmidt, Kay Thurley, Dietmar Schmitz, and Richard Kempter PMCID: PMC2393792 Enduring effects of early structured noise exposure on temporal modulation in the primary auditory cortex Xiaoming Zhou and Michael M. Merzenich PMCID: PMC2393777 Aberrant early-phase ERK inactivation impedes neuronal function in fragile X syndrome Soong Ho Kim, Julie A. Markham, Ivan Jeanne Weiler, and William T. Greenough PMCID: PMC2393788 Molecular mechanisms that control initiation and termination of physiological depolarization-evoked transmitter release Yonatan M. Kupchik, Grigory Rashkovan, Lily Ohana, Tal Keren-Raifman, Nathan Dascal, Hanna Parnas, and Itzchak Parnas PMCID: PMC2393753 Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons Winnie S. Liang, Eric M. Reiman, Jon Valla, Travis Dunckley, Thomas G. Beach, Andrew Grover, Tracey L. Niedzielko, Lonnie E. Schneider, Diego Mastroeni, Richard Caselli, Walter Kukull, John C. Morris, Christine M. Hulette, Donald Schmechel, Joseph Rogers, and Dietrich A. Stephan PMCID: PMC2393743 The distribution of category and location information across object-selective regions in human visual cortex Rebecca F. Schwarzlose, Jascha D. Swisher, Sabin Dang, and Nancy Kanwisher PMCID: PMC2393746 Organization of the core structure of the postsynaptic density Xiaobing Chen, Christine Winters, Rita Azzam, Xiang Li, James A. Galbraith, Richard D. Leapman, and Thomas S. Reese PMCID: PMC2393784 A brain-specific SGK1 splice isoform regulates expression of ASIC1 in neurons Maria F. Arteaga, Tatjana Coric, Christoph Straub, and Cecilia M. Canessa PMCID: PMC2393749 Experience is required for the maintenance and refinement of FM sweep selectivity in the developing auditory cortex Khaleel A. Razak, Marlin D. Richardson, and Zoltan M. Fuzessery PMCID: PMC2393755 Pharmacology A preclinical model for predicting drug response in soft-tissue sarcoma with targeted AAVP molecular imaging Amin Hajitou, Dina C. Lev, Jonathan A. F. Hannay, Borys Korchin, Fernanda I. Staquicini, Suren Soghomonyan, Mian M. Alauddin, Robert S. Benjamin, Raphael E. Pollock, Juri G. Gelovani, Renata Pasqualini, and Wadih Arap PMCID: PMC2393798 Physiology CAPON modulates cardiac repolarization via neuronal nitric oxide synthase signaling in the heart Kuan-Cheng Chang, Andreas S. Barth, Tetsuo Sasano, Eddy Kizana, Yuji Kashiwakura, Yiqiang Zhang, D. Brian Foster, and Eduardo Marbán PMCID: PMC2393814 P-Rex2 regulates Purkinje cell dendrite morphology and motor coordination Sarah Donald, Trevor Humby, Ian Fyfe, Anne Segonds-Pichon, Simon A. Walker, Simon R. Andrews, W. John Coadwell, Piers Emson, Lawrence S. Wilkinson, and Heidi C. E. Welch PMCID: PMC2393786 Plant Biology Auxin transport inhibitors impair vesicle motility and actin cytoskeleton dynamics in diverse eukaryotes Pankaj Dhonukshe, Ilya Grigoriev, Rainer Fischer, Motoki Tominaga, David G. Robinson, Jiří Hašek, Tomasz Paciorek, Jan Petrášek, Daniela Seifertová, Ricardo Tejos, Lee A. Meisel, Eva Zažímalová, Theodorus W. J. Gadella, Jr, York-Dieter Stierhof, Takashi Ueda, Kazuhiro Oiwa, Anna Akhmanova, Roland Brock, Anne Spang, and Jiří Friml PMCID: PMC2393819 Integration of light and abscisic acid signaling during seed germination and early seedling development Hao Chen, Jingyu Zhang, Michael M. Neff, Suk-Whan Hong, Huiyong Zhang, Xing-Wang Deng, and Liming Xiong PMCID: PMC2393781 RNAi-mediated suppression of p-coumaroyl-CoA 3′-hydroxylase in hybrid poplar impacts lignin deposition and soluble secondary metabolism Heather D. Coleman, Ji-Young Park, Ramesh Nair, Clint Chapple, and Shawn D. Mansfield PMCID: PMC2393750 Psychology From the Cover:
Repetition suppression of ventromedial prefrontal activity during judgments of self and others Adrianna C. Jenkins, C. Neil Macrae, and Jason P. Mitchell PMCID: PMC2393803 Sustainability Science Corn-based ethanol production compromises goal of reducing nitrogen export by the Mississippi River Simon D. Donner and Christopher J. Kucharik PMCID: PMC2393748 Invasive plants transform the three-dimensional structure of rain forests Gregory P. Asner, R. Flint Hughes, Peter M. Vitousek, David E. Knapp, Ty Kennedy-Bowdoin, Joseph Boardman, Roberta E. Martin, Michael Eastwood, and Robert O. Green PMCID: PMC2393775 Plants can use protein as a nitrogen source without assistance from other organisms Chanyarat Paungfoo-Lonhienne, Thierry G. A. Lonhienne, Doris Rentsch, Nicole Robinson, Michael Christie, Richard I. Webb, Harshi K. Gamage, Bernard J. Carroll, Peer M. Schenk, and Susanne Schmidt PMCID: PMC2393761 Social Sciences Anthropology From the Cover:
The protracted Holocene extinction of California's flightless sea duck (Chendytes lawi) and its implications for the Pleistocene overkill hypothesis T. L. Jones, J. F. Porcasi, J. M. Erlandson, H. Dallas, Jr., T. A. Wake, and R. Schwaderer PMCID: PMC2393816 Psychology A human intracranial study of long-range oscillatory coherence across a frontal–occipital–hippocampal brain network during visual object processing Pejman Sehatpour, Sophie Molholm, Theodore H. Schwartz, Jeannette R. Mahoney, Ashesh D. Mehta, Daniel C. Javitt, Patric K. Stanton, and John J. Foxe PMCID: PMC2393806 From the Cover:
Repetition suppression of ventromedial prefrontal activity during judgments of self and others Adrianna C. Jenkins, C. Neil Macrae, and Jason P. Mitchell PMCID: PMC2393803 Social Sciences Understanding the social context of the Schelling segregation model William A. V. Clark and Mark Fossett PMCID: PMC2393808 Correction Correction for He et al., Bcl-xL overexpression blocks bax-mediated mitochondrial contact site formation and apoptosis in rod photoreceptors of lead-exposed mice PMCID: PMC2393787 Corrects: Lihua He, et al. Bcl-xL overexpression blocks bax-mediated mitochondrial contact site formation and apoptosis in rod photoreceptors of lead-exposed mice. Proc Natl Acad Sci U S A. 2003 February 4; 100(3): 1022–1027. |
