| | This journal provides immediate access to some articles. This Week in PNAS Proc Natl Acad Sci U S A. 2008 April 15; 105(15): 5651–5652. doi: 10.1073/iti1508105.PMCID: PMC2311364 Commentaries Knockout punches with a fistful of zinc fingers John H. Wilson PMCID: PMC2311346 Morphing peptide backbones into heterocycles Christopher T. Walsh and Elizabeth M. Nolan PMCID: PMC2311349 Physical Sciences Chemistry Molecular assembly for high-performance bivalent nucleic acid inhibitor Youngmi Kim, Zehui Cao, and Weihong Tan PMCID: PMC2311377 Incorrect nucleotide insertion at the active site of a G:A mismatch catalyzed by DNA polymerase β Ping Lin, Vinod K. Batra, Lars C. Pedersen, William A. Beard, Samuel H. Wilson, and Lee G. Pedersen PMCID: PMC2311328 Physics Probing microscopic origins of confined subdiffusion by first-passage observables S. Condamin, V. Tejedor, R. Voituriez, O. Bénichou, and J. Klafter PMCID: PMC2311379 Biological Sciences Biochemistry Molecular assembly for high-performance bivalent nucleic acid inhibitor Youngmi Kim, Zehui Cao, and Weihong Tan PMCID: PMC2311377 Incorrect nucleotide insertion at the active site of a G:A mismatch catalyzed by DNA polymerase β Ping Lin, Vinod K. Batra, Lars C. Pedersen, William A. Beard, Samuel H. Wilson, and Lee G. Pedersen PMCID: PMC2311328 From the Cover:
Identification of a vesicular nucleotide transporter Keisuke Sawada, Noriko Echigo, Narinobu Juge, Takaaki Miyaji, Masato Otsuka, Hiroshi Omote, Akitsugu Yamamoto, and Yoshinori Moriyama PMCID: PMC2311367 The catalytic scaffold of the haloalkanoic acid dehalogenase enzyme superfamily acts as a mold for the trigonal bipyramidal transition state Zhibing Lu, Debra Dunaway-Mariano, and Karen N. Allen PMCID: PMC2311376 Protein kinase CK2 as an ectokinase: The role of the regulatory CK2β subunit Fernando A. Rodriguez, Carlos Contreras, Víctor Bolanos-Garcia, and Jorge E. Allende PMCID: PMC2311332 A relaxed active site after exon ligation by the group I intron Sarah V. Lipchock and Scott A. Strobel PMCID: PMC2311373 Activation of the lifespan regulator p66Shc through reversible disulfide bond formation Melanie Gertz, Frank Fischer, Dirk Wolters, and Clemens Steegborn PMCID: PMC2311372 Calcium sensitivity of the cross-bridge cycle of Myo1c, the adaptation motor in the inner ear Nancy Adamek, Lynne M. Coluccio, and Michael A. Geeves PMCID: PMC2299219 An insulin-like peptide regulates egg maturation and metabolism in the mosquito Aedes aegypti Mark R. Brown, Kevin D. Clark, Monika Gulia, Zhangwu Zhao, Stephen F. Garczynski, Joe W. Crim, Richard J. Suderman, and Michael R. Strand PMCID: PMC2311378 Quality control of overexpressed membrane proteins Eric R. Geertsma, Maarten Groeneveld, Dirk-Jan Slotboom, and Bert Poolman PMCID: PMC2311375 Enzymatic mechanism and product specificity of SET-domain protein lysine methyltransferases Xiaodong Zhang and Thomas C. Bruice PMCID: PMC2311330 Saturation mutagenesis of putative catalytic residues of benzoylformate decarboxylase provides a challenge to the accepted mechanism Alejandra Yep, George L. Kenyon, and Michael J. McLeish PMCID: PMC2311329 Structure of human monoamine oxidase A at 2.2-Å resolution: The control of opening the entry for substrates/inhibitors Se-Young Son, Jichun Ma, Youhei Kondou, Masato Yoshimura, Eiki Yamashita, and Tomitake Tsukihara PMCID: PMC2311356 Conservation analysis predicts in vivo occupancy of glucocorticoid receptor-binding sequences at glucocorticoid-induced genes Alex Yick-Lun So, Samantha B. Cooper, Brian J. Feldman, Mitra Manuchehri, and Keith R. Yamamoto PMCID: PMC2311370 In vivo functions of the proprotein convertase PC5/6 during mouse development: Gdf11 is a likely substrate Rachid Essalmani, Ahmed Zaid, Jadwiga Marcinkiewicz, Ann Chamberland, Antonella Pasquato, Nabil G. Seidah, and Annik Prat PMCID: PMC2299217 Biophysics Temperature and pressure dependence of protein stability: The engineered fluorescein-binding lipocalin FluA shows an elliptic phase diagram Johannes Wiedersich, Simone Köhler, Arne Skerra, and Josef Friedrich PMCID: PMC2311345 Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain Mark Wells, Henning Tidow, Trevor J. Rutherford, Phineus Markwick, Malene Ringkjobing Jensen, Efstratios Mylonas, Dmitri I. Svergun, Martin Blackledge, and Alan R. Fersht PMCID: PMC2311362 Cell Biology From the Cover:
Magnesium deficiency accelerates cellular senescence in cultured human fibroblasts David W. Killilea and Bruce N. Ames PMCID: PMC2311331 Rare steroid receptor-negative basal-like tumorigenic cells in luminal subtype human breast cancer xenografts Kathryn B. Horwitz, Wendy W. Dye, Joshua Chuck Harrell, Peter Kabos, and Carol A. Sartorius PMCID: PMC2311360 Developmental Biology Tlx3 exerts context-dependent transcriptional regulation and promotes neuronal differentiation from embryonic stem cells Takako Kondo, Patrick L. Sheets, David A. Zopf, Heather L. Aloor, Theodore R. Cummins, Rebecca J. Chan, and Eri Hashino PMCID: PMC2311353 Evolution Stable isotope evidence for an amphibious phase in early proboscidean evolution Alexander G. S. C. Liu, Erik R. Seiffert, and Elwyn L. Simons PMCID: PMC2311368 Differences in spontaneous mutation frequencies as a function of environmental stress in soil fungi at “Evolution Canyon,” Israel Bernard C. Lamb, Snehal Mandaokar, Basma Bahsoun, Isabella Grishkan, and Eviatar Nevo PMCID: PMC2311348 RNA landscape of evolution for optimal exon and intron discrimination Chaolin Zhang, Wen-Hsiung Li, Adrian R. Krainer, and Michael Q. Zhang PMCID: PMC2311341 The genome of Bacillus coahuilensis reveals adaptations essential for survival in the relic of an ancient marine environment Luis David Alcaraz, Gabriela Olmedo, Germán Bonilla, René Cerritos, Gustavo Hernández, Alfredo Cruz, Enrique Ramírez, Catherine Putonti, Beatriz Jiménez, Eva Martínez, Varinia López, Jacqueline L. Arvizu, Francisco Ayala, Francisco Razo, Juan Caballero, Janet Siefert, Luis Eguiarte, Jean-Philippe Vielle, Octavio Martínez, Valeria Souza, Alfredo Herrera-Estrella, and Luis Herrera-Estrella PMCID: PMC2311347 Genetics From the Cover:
Targeted gene knockout in mammalian cells by using engineered zinc-finger nucleases Yolanda Santiago, Edmond Chan, Pei-Qi Liu, Salvatore Orlando, Lin Zhang, Fyodor D. Urnov, Michael C. Holmes, Dmitry Guschin, Adam Waite, Jeffrey C. Miller, Edward J. Rebar, Philip D. Gregory, Aaron Klug, and Trevor N. Collingwood PMCID: PMC2299223 Fine structure mapping of a gene-rich region of wheat carrying Ph1, a suppressor of crossing over between homoeologous chromosomes Gaganpreet K. Sidhu, Sachin Rustgi, Mustafa N. Shafqat, Diter von Wettstein, and Kulvinder S. Gill PMCID: PMC2311334 Linking functionally related genes by sensitive and quantitative characterization of genetic interaction profiles Laurence Decourty, Cosmin Saveanu, Kenza Zemam, Florence Hantraye, Emmanuel Frachon, Jean-Claude Rousselle, Micheline Fromont-Racine, and Alain Jacquier PMCID: PMC2311358 DNA looping can enhance lysogenic CI transcription in phage lambda L. Meadow Anderson and Haw Yang PMCID: PMC2311354 Cassandra retrotransposons carry independently transcribed 5S RNA Ruslan Kalendar, Jaakko Tanskanen, Wei Chang, Kristiina Antonius, Hanan Sela, Ofer Peleg, and Alan H. Schulman PMCID: PMC2311327 Immunology Hybrid alphavirus–rhabdovirus propagating replicon particles are versatile and potent vaccine vectors Nina F. Rose, Jean Publicover, Anasuya Chattopadhyay, and John K. Rose PMCID: PMC2311333 Medical Sciences Noninvasive molecular imaging of small living subjects using Raman spectroscopy S. Keren, C. Zavaleta, Z. Cheng, A. de la Zerda, O. Gheysens, and S. S. Gambhir PMCID: PMC2299220 Protection against heterologous human papillomavirus challenge by a synthetic lipopeptide vaccine containing a broadly cross-neutralizing epitope of L2 Hannah H. Alphs, Ratish Gambhira, Balasubramanyam Karanam, Jeffrey N. Roberts, Subhashini Jagu, John T. Schiller, Weiguang Zeng, David C. Jackson, and Richard B. S. Roden PMCID: PMC2299222 Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease Marius Wernig, Jian-Ping Zhao, Jan Pruszak, Eva Hedlund, Dongdong Fu, Frank Soldner, Vania Broccoli, Martha Constantine-Paton, Ole Isacson, and Rudolf Jaenisch PMCID: PMC2311361 Presecretory oxidation, aggregation, and autophagic destruction of apoprotein-B: A pathway for late-stage quality control Meihui Pan, Vatsala Maitin, Sajesh Parathath, Ursula Andreo, Sharron X. Lin, Carly St. Germain, Zemin Yao, Frederick R. Maxfield, Kevin Jon Williams, and Edward A. Fisher PMCID: PMC2311371 Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: Implications for the therapeutic development of RNAi Jodi L. McBride, Ryan L. Boudreau, Scott Q. Harper, Patrick D. Staber, Alex Mas Monteys, Inâs Martins, Brian L. Gilmore, Haim Burstein, Richard W. Peluso, Barry Polisky, Barrie J. Carter, and Beverly L. Davidson PMCID: PMC2311380 MicroRNA 29c is down-regulated in nasopharyngeal carcinomas, up-regulating mRNAs encoding extracellular matrix proteins Srikumar Sengupta, Johan A. den Boon, I-How Chen, Michael A. Newton, Stephen A. Stanhope, Yu-Juen Cheng, Chien-Jen Chen, Allan Hildesheim, Bill Sugden, and Paul Ahlquist PMCID: PMC2311339 Microbiology From the Cover:
Discovery of a widely distributed toxin biosynthetic gene cluster Shaun W. Lee, Douglas A. Mitchell, Andrew L. Markley, Mary E. Hensler, David Gonzalez, Aaron Wohlrab, Pieter C. Dorrestein, Victor Nizet, and Jack E. Dixon PMCID: PMC2311365 Bacterial addiction module toxin Doc inhibits translation elongation through its association with the 30S ribosomal subunit Mohan Liu, Yonglong Zhang, Masayori Inouye, and Nancy A. Woychik PMCID: PMC2311363 An essential sensor histidine kinase controlled by transmembrane helix interactions with its auxiliary proteins Hendrik Szurmant, Lintao Bu, Charles L. Brooks, III, and James A. Hoch PMCID: PMC2311355 An overlapping essential gene in the Potyviridae Betty Y.-W. Chung, W. Allen Miller, John F. Atkins, and Andrew E. Firth PMCID: PMC2311343 Rational chemical design of the carbohydrate in a glycoconjugate vaccine enhances IgM-to-IgG switching Hilde-Kari Guttormsen, Lawrence C. Paoletti, Keith G. Mansfield, Wojcieck Jachymek, Harold J. Jennings, and Dennis L. Kasper PMCID: PMC2311338 Neuroscience INAUGURAL ARTICLE by a Recently Elected Academy Member: A common genetic target for environmental and heritable influences on aggressiveness in DrosophilaLiming Wang, Heiko Dankert, Pietro Perona, and David J. Anderson PMCID: PMC2311352 Distinct error-correcting and incidental learning of location relative to landmarks and boundaries Christian F. Doeller and Neil Burgess PMCID: PMC2311326 Parallel striatal and hippocampal systems for landmarks and boundaries in spatial memory Christian F. Doeller, John A. King, and Neil Burgess PMCID: PMC2311337 Activity-dependent repression of muscle genes by NFAT Zaheer A. Rana, Kristian Gundersen, and Andres Buonanno PMCID: PMC2311374 Plant Biology From the Cover:
Scent evolution in Chinese roses Gabriel Scalliet, Florence Piola, Christophe J. Douady, Stéphane Réty, Olivier Raymond, Sylvie Baudino, Karim Bordji, Mohammed Bendahmane, Christian Dumas, J. Mark Cock, and Philippe Hugueney PMCID: PMC2311369 Salt tolerance of Arabidopsis thaliana requires maturation of N-glycosylated proteins in the Golgi apparatus Jae Sook Kang, Julia Frank, Chang Ho Kang, Hiroyuki Kajiura, Meenu Vikram, Akihiro Ueda, Sewon Kim, Jeong Dong Bahk, Barbara Triplett, Kazuhito Fujiyama, Sang Yeol Lee, Antje von Schaewen, and Hisashi Koiwa PMCID: PMC2311335 Psychology Spectral completion of partially masked sounds Josh H. McDermott and Andrew J. Oxenham PMCID: PMC2311350 Social Sciences Social Sciences Son-biased sex ratios in the 2000 United States Census Douglas Almond and Lena Edlund PMCID: PMC2311342 Corrections Correction for Zhang et al., Anyonic braiding in optical lattices PMCID: PMC2311344 Corrects: Chuanwei Zhang, et al. Anyonic braiding in optical lattices. Proc Natl Acad Sci U S A. 2007 November 20; 104(47): 18415–18420. Correction for Barbano et al., A mathematical tool for exploring the dynamics of biological networks PMCID: PMC2311359 Corrects: Paolo E. Barbano, et al. A mathematical tool for exploring the dynamics of biological networks. Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19169–19174. |
