| | This journal provides immediate access to some articles. Inaugural Article EPLIN mediates linkage of the cadherin–catenin complex to F-actin and stabilizes the circumferential actin belt Kentaro Abe and Masatoshi Takeichi PMCID: PMC2224173 Letters How many guests, what sort of hosts? Mark Donohue PMCID: PMC2224240 Reply: Inference and Proto-Sumba J. Stephen Lansing PMCID: PMC2224241 This Week in PNAS Proc Natl Acad Sci U S A. 2008 January 8; 105(1): 1–2. doi: 10.1073/iti0108105.PMCID: PMC2224165 Editorial Science, evolution, and creationism Francisco J. Ayala PMCID: PMC2224205 Commentaries Diamond, diamond cells, and the structure of element 11 N. W. Ashcroft PMCID: PMC2224229 Shedding (blue) light on algal gene expression Aba Losi and Wolfgang Gärtner PMCID: PMC2224233 Using aliens to explore how our planet works Tim M. Blackburn PMCID: PMC2224238 Unraveling prion strains with cell biology and organic chemistry Adriano Aguzzi PMCID: PMC2224168 Physical Sciences Applied Physical Sciences From the Cover:
Pressure-induced metallization of silane Xiao-Jia Chen, Viktor V. Struzhkin, Yang Song, Alexander F. Goncharov, Muhtar Ahart, Zhenxian Liu, Ho-kwang Mao, and Russell J. Hemley PMCID: PMC2224186 High numerical aperture tabletop soft x-ray diffraction microscopy with 70-nm resolution Richard L. Sandberg, Changyong Song, Przemyslaw W. Wachulak, Daisy A. Raymondson, Ariel Paul, Bagrat Amirbekian, Edwin Lee, Anne E. Sakdinawat, Chan La-O-Vorakiat, Mario C. Marconi, Carmen S. Menoni, Margaret M. Murnane, Jorge J. Rocca, Henry C. Kapteyn, and Jianwei Miao PMCID: PMC2224193 Chemistry Selective photoinactivation of protein function through environment-sensitive switching of singlet oxygen generation by photosensitizer Takatoshi Yogo, Yasuteru Urano, Akiko Mizushima, Hisato Sunahara, Takanari Inoue, Kenzo Hirose, Masamitsu Iino, Kazuya Kikuchi, and Tetsuo Nagano PMCID: PMC2224201 Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities Benfang Ruan, Kevin Pong, Flora Jow, Mark Bowlby, Robert A. Crozier, Danni Liu, Shi Liang, Yi Chen, Mary Lynn Mercado, Xidong Feng, Frann Bennett, David von Schack, Leonard McDonald, Margaret M. Zaleska, Andrew Wood, Peter H. Reinhart, Ronald L. Magolda, Jerauld Skotnicki, Menelas N. Pangalos, Frank E. Koehn, Guy T. Carter, Magid Abou-Gharbia, and Edmund I. Graziani PMCID: PMC2224212 Phase diagram of water in carbon nanotubes Daisuke Takaiwa, Itaru Hatano, Kenichiro Koga, and Hideki Tanaka PMCID: PMC2224223 Geophysics From the Cover:
Estimating terrestrial uranium and thorium by antineutrino flux measurements Stephen T. Dye and Eugene H. Guillian PMCID: PMC2224227 Biological Sciences Applied Biological Sciences Extracellular matrix production and calcium carbonate precipitation by coral cells in vitro Yael Helman, Frank Natale, Robert M. Sherrell, Michèle LaVigne, Valentin Starovoytov, Maxim Y. Gorbunov, and Paul G. Falkowski PMCID: PMC2224230 Three-dimensional cellular microarray for high-throughput toxicology assays Moo-Yeal Lee, R. Anand Kumar, Sumitra M. Sukumaran, Michael G. Hogg, Douglas S. Clark, and Jonathan S. Dordick PMCID: PMC2224231 Biochemistry Selective photoinactivation of protein function through environment-sensitive switching of singlet oxygen generation by photosensitizer Takatoshi Yogo, Yasuteru Urano, Akiko Mizushima, Hisato Sunahara, Takanari Inoue, Kenzo Hirose, Masamitsu Iino, Kazuya Kikuchi, and Tetsuo Nagano PMCID: PMC2224201 From the Cover:
The genetic design of signaling cascades to record receptor activation Gilad Barnea, Walter Strapps, Gilles Herrada, Yemiliya Berman, Jane Ong, Brian Kloss, Richard Axel, and Kevin J. Lee PMCID: PMC2224232 A continuous hyperchromicity assay to characterize the kinetics and thermodynamics of DNA lesion recognition and base excision Conceição A. S. A. Minetti, David P. Remeta, and Kenneth J. Breslauer PMCID: PMC2224234 The N-end rule pathway is a sensor of heme Rong-Gui Hu, Haiqing Wang, Zanxian Xia, and Alexander Varshavsky PMCID: PMC2224235 Synthetic antibodies for specific recognition and crystallization of structured RNA Jing-Dong Ye, Valentina Tereshko, John K. Frederiksen, Akiko Koide, Frederic A. Fellouse, Sachdev S. Sidhu, Shohei Koide, Anthony A. Kossiakoff, and Joseph A. Piccirilli PMCID: PMC2224236 Mammalian acyl-CoA:lysophosphatidylcholine acyltransferase enzymes Eric Soupene, Henrik Fyrst, and Frans A. Kuypers PMCID: PMC2224237 Evolutionarily conserved gene family important for fat storage Bert Kadereit, Pradeep Kumar, Wen-Jun Wang, Diego Miranda, Erik L. Snapp, Nadia Severina, Ingrid Torregroza, Todd Evans, and David L. Silver PMCID: PMC2224239 Synthetic heterovalent inhibitors targeting recognition E3 components of the N-end rule pathway Min Jae Lee, Krishnendu Pal, Takafumi Tasaki, Sayantani Roy, Yonghua Jiang, Jee Young An, Rajkumar Banerjee, and Yong Tae Kwon PMCID: PMC2224166 p53 and TFIIEα share a common binding site on the Tfb1/p62 subunit of TFIIH Paola Di Lello, Lisa M. Miller Jenkins, Caroline Mas, Chantal Langlois, Elena Malitskaya, Amélie Fradet-Turcotte, Jacques Archambault, Pascale Legault, and James G. Omichinski PMCID: PMC2224167 Heterogeneity in EGF-binding affinities arises from negative cooperativity in an aggregating system Jennifer L. Macdonald and Linda J. Pike PMCID: PMC2224169 Biophysics Origins of barriers and barrierless folding in BBL Samuel S. Cho, Patrick Weinkam, and Peter G. Wolynes PMCID: PMC2224170 Tuning lipid mixtures to induce or suppress domain formation across leaflets of unsupported asymmetric bilayers Marcus D. Collins and Sarah L. Keller PMCID: PMC2224171 A threading-based method (FINDSITE) for ligand-binding site prediction and functional annotation Michal Brylinski and Jeffrey Skolnick PMCID: PMC2224172 Single-molecule tracking of mRNA exiting from RNA polymerase II Joanna Andrecka, Robert Lewis, Florian Brückner, Elisabeth Lehmann, Patrick Cramer, and Jens Michaelis PMCID: PMC2224174 Stepwise dynamics of epitaxially growing single amyloid fibrils Miklós S. Z. Kellermayer, Árpád Karsai, Margit Benke, Katalin Soós, and Botond Penke PMCID: PMC2224175 Cell Biology EPLIN mediates linkage of the cadherin–catenin complex to F-actin and stabilizes the circumferential actin belt Kentaro Abe and Masatoshi Takeichi PMCID: PMC2224173 The Parkinson's disease protein α-synuclein disrupts cellular Rab homeostasis Aaron D. Gitler, Brooke J. Bevis, James Shorter, Katherine E. Strathearn, Shusei Hamamichi, Linhui Julie Su, Kim A. Caldwell, Guy A. Caldwell, Jean-Christophe Rochet, J. Michael McCaffery, Charles Barlowe, and Susan Lindquist PMCID: PMC2224176 Visualization of AP-1–NF-κB ternary complexes in living cells by using a BiFC-based FRET Y. John Shyu, Christopher D. Suarez, and Chang-Deng Hu PMCID: PMC2224177 Interaction with host SGS3 is required for suppression of RNA silencing by tomato yellow leaf curl virus V2 protein Efrat Glick, Avi Zrachya, Yael Levy, Anahit Mett, David Gidoni, Eduard Belausov, Vitaly Citovsky, and Yedidya Gafni PMCID: PMC2224178 Down-regulation of 14-3-3ζ suppresses anchorage-independent growth of lung cancer cells through anoikis activation Zenggang Li, Jing Zhao, Yuhong Du, Hae Ryoun Park, Shi-Yong Sun, Leon Bernal-Mizrachi, Alastair Aitken, Fadlo R. Khuri, and Haian Fu PMCID: PMC2224179 Clathrin light chains function in mannose phosphate receptor trafficking via regulation of actin assembly Viviane Poupon, Martine Girard, Valerie Legendre-Guillemin, Sebastien Thomas, Lyne Bourbonniere, Jacynthe Philie, Nicholas A. Bright, and Peter S. McPherson PMCID: PMC2224180 A chemical genomics screen highlights the essential role of mitochondria in HIF-1 regulation Xiaoyu Lin, Caroline A. David, Jennifer B. Donnelly, Mike Michaelides, Navdeep S. Chandel, Xiaoli Huang, Usha Warrior, Frank Weinberg, Kathryn V. Tormos, Stephen W. Fesik, and Yu Shen PMCID: PMC2224181 Laminopathic mutations interfere with the assembly, localization, and dynamics of nuclear lamins Naama Wiesel, Anna Mattout, Shai Melcer, Naomi Melamed-Book, Harald Herrmann, Ohad Medalia, Ueli Aebi, and Yosef Gruenbaum PMCID: PMC2224182 Dioxin-mediated tumor progression through activation of mitochondria-to-nucleus stress signaling Gopa Biswas, Satish Srinivasan, Hindupur K. Anandatheerthavarada, and Narayan G. Avadhani PMCID: PMC2224183 Developmental Biology Retinal progenitor cells can produce restricted subsets of horizontal cells S. B. Rompani and C. L. Cepko PMCID: PMC2224184 Ca2+ channel-independent requirement for MAGUK family CACNB4 genes in initiation of zebrafish epiboly A. M. Ebert, C. A. McAnelly, A. Srinivasan, J. L. Linker, W. A. Horne, and D. M. Garrity PMCID: PMC2224185 Hip, an HP1-interacting protein, is a haplo- and triplo-suppressor of position effect variegation Alexander Schwendemann, Tanja Matkovic, Christian Linke, Ansgar Klebes, Annemarie Hofmann, and Günter Korge PMCID: PMC2224187 Mechanism of activation of the Formin protein Daam1 Wei Liu, Akira Sato, Deepak Khadka, Ritu Bharti, Hector Diaz, Loren W. Runnels, and Raymond Habas PMCID: PMC2224188 Ecology Costs and benefits of cold acclimation in field-released Drosophila Torsten N. Kristensen, Ary A. Hoffmann, Johannes Overgaard, Jesper G. Sørensen, Rebecca Hallas, and Volker Loeschcke PMCID: PMC2224189 From the Cover:
Behavioral tradeoff in estuarine larvae favors seaward migration over minimizing visibility to predators Steven G. Morgan and Jean R. Anastasia PMCID: PMC2224190 Amplified temperature dependence in ecosystems developing on the lava flows of Mauna Loa, Hawai'i Kristina J. Anderson-Teixeira, Peter M. Vitousek, and James H. Brown PMCID: PMC2224191 Evolution Evolutionary origin of the amnioserosa in cyclorrhaphan flies correlates with spatial and temporal expression changes of zen Ab. Matteen Rafiqi, Steffen Lemke, Sean Ferguson, Michael Stauber, and Urs Schmidt-Ott PMCID: PMC2224192 Early steps of angiosperm–pollinator coevolution Shusheng Hu, David L. Dilcher, David M. Jarzen, and David Winship Taylor PMCID: PMC2224194 Genetics Replication stress induces tumor-like microdeletions in FHIT/FRA3B Sandra G. Durkin, Ryan L. Ragland, Martin F. Arlt, Jennifer G. Mulle, Stephen T. Warren, and Thomas W. Glover PMCID: PMC2224195 High-resolution mapping of DNA hypermethylation and hypomethylation in lung cancer Tibor A. Rauch, Xueyan Zhong, Xiwei Wu, Melody Wang, Kemp H. Kernstine, Zunde Wang, Arthur D. Riggs, and Gerd P. Pfeifer PMCID: PMC2224196 Immunology The TLR3 signaling complex forms by cooperative receptor dimerization Joshua N. Leonard, Rodolfo Ghirlando, Janine Askins, Jessica K. Bell, David H. Margulies, David R. Davies, and David M. Segal PMCID: PMC2224197 Mycobacterium tuberculosis Rv2224c modulates innate immune responses Jyothi Rengarajan, Elissa Murphy, Arnold Park, Cassandra L. Krone, Erik C. Hett, Barry R. Bloom, Laurie H. Glimcher, and Eric J. Rubin PMCID: PMC2224198 Medical Sciences A model for obesity and gigantism due to disruption of the Ankrd26 gene Tapan K. Bera, Xiu-Fen Liu, Masanori Yamada, Oksana Gavrilova, Eva Mezey, Lino Tessarollo, Miriam Anver, Yoonsoo Hahn, Byungkook Lee, and Ira Pastan PMCID: PMC2224199 Disruption of the RIIβ subunit of PKA reverses the obesity syndrome of agouti lethal yellow mice Traci A. Czyzyk, Maria A. Sikorski, Linghai Yang, and G. Stanley McKnight PMCID: PMC2224200 Transgenic system for conditional induction and rescue of chronic myocardial hibernation provides insights into genomic programs of hibernation Dalit May, Dan Gilon, Valentin Djonov, Ahuva Itin, Alon Lazarus, Oren Gordon, Christian Rosenberger, and Eli Keshet PMCID: PMC2224202 Tamoxifen-stimulated growth of breast cancer due to p21 loss Abde M. Abukhdeir, Michele I. Vitolo, Pedram Argani, Angelo M. De Marzo, Bedri Karakas, Hiroyuki Konishi, John P. Gustin, Josh Lauring, Joseph P. Garay, Courtney Pendleton, Yuko Konishi, Brian G. Blair, Keith Brenner, Elizabeth Garrett-Mayer, Hetty Carraway, Kurtis E. Bachman, and Ben Ho Park PMCID: PMC2224203 Microbiology SOCS1 is an inducible host factor during HIV-1 infection and regulates the intracellular trafficking and stability of HIV-1 Gag Akihide Ryo, Naomi Tsurutani, Kenji Ohba, Ryuichiro Kimura, Jun Komano, Mayuko Nishi, Hiromi Soeda, Shinichiro Hattori, Kilian Perrem, Mikio Yamamoto, Joe Chiba, Jun-ichi Mimaya, Kazuhisa Yoshimura, Shuzo Matsushita, Mitsuo Honda, Akihiko Yoshimura, Tatsuya Sawasaki, Ichiro Aoki, Yuko Morikawa, and Naoki Yamamoto PMCID: PMC2224204 Methane oxidation at 55°C and pH 2 by a thermoacidophilic bacterium belonging to the Verrucomicrobia phylum Tajul Islam, Sigmund Jensen, Laila Johanne Reigstad, Øivind Larsen, and Nils-Kåre Birkeland PMCID: PMC2224206 A combined transcriptome and proteome survey of malaria parasite liver stages Alice S. Tarun, Xinxia Peng, Ronald F. Dumpit, Yuko Ogata, Hilda Silva-Rivera, Nelly Camargo, Thomas M. Daly, Lawrence W. Bergman, and Stefan H. I. Kappe PMCID: PMC2224207 Neuroscience Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities Benfang Ruan, Kevin Pong, Flora Jow, Mark Bowlby, Robert A. Crozier, Danni Liu, Shi Liang, Yi Chen, Mary Lynn Mercado, Xidong Feng, Frann Bennett, David von Schack, Leonard McDonald, Margaret M. Zaleska, Andrew Wood, Peter H. Reinhart, Ronald L. Magolda, Jerauld Skotnicki, Menelas N. Pangalos, Frank E. Koehn, Guy T. Carter, Magid Abou-Gharbia, and Edmund I. Graziani PMCID: PMC2224212 Mice with targeted Slc4a10 gene disruption have small brain ventricles and show reduced neuronal excitability Stefan Jacobs, Eva Ruusuvuori, Sampsa T. Sipilä, Aleksi Haapanen, Helle H. Damkier, Ingo Kurth, Moritz Hentschke, Michaela Schweizer, York Rudhard, Linda M. Laatikainen, Jaana Tyynelä, Jeppe Praetorius, Juha Voipio, and Christian A. Hübner PMCID: PMC2224208 From the Cover:
Multiroute memories in desert ants Stefan Sommer, Christoph von Beeren, and Rüdiger Wehner PMCID: PMC2224209 Activity-dependent phosphorylation of Ser187 is required for SNAP-25-negative modulation of neuronal voltage-gated calcium channels Davide Pozzi, Steven Condliffe, Yuri Bozzi, Maia Chikhladze, Carlotta Grumelli, Véronique Proux-Gillardeaux, Masami Takahashi, Silvana Franceschetti, Claudia Verderio, and Michela Matteoli PMCID: PMC2224210 Activity of human hippocampal and amygdala neurons during retrieval of declarative memories Ueli Rutishauser, Erin M. Schuman, and Adam N. Mamelak PMCID: PMC2224211 Instructive role of aPKCζ subcellular localization in the assembly of adherens junctions in neural progenitors Sourav Ghosh, Till Marquardt, Joshua P. Thaler, Nigel Carter, Shane E. Andrews, Samuel L. Pfaff, and Tony Hunter PMCID: PMC2224213 Modulation of CaV2.1 channels by Ca2+/calmodulin-dependent protein kinase II bound to the C-terminal domain Xin Jiang, Nathan J. Lautermilch, Hirofumi Watari, Ruth E. Westenbroek, Todd Scheuer, and William A. Catterall PMCID: PMC2224214 Photolysis of a caged peptide reveals rapid action of N-ethylmaleimide sensitive factor before neurotransmitter release T. Kuner, Y. Li, K. R. Gee, L. F. Bonewald, and G. J. Augustine PMCID: PMC2224215 The varitint-waddler (Va) deafness mutation in TRPML3 generates constitutive, inward rectifying currents and causes cell degeneration Keiichi Nagata, Lili Zheng, Thomas Madathany, Andrew J. Castiglioni, James R. Bartles, and Jaime García-Añoveros PMCID: PMC2224216 Stress blunts serotonin- and hypocretin-evoked EPSCs in prefrontal cortex: Role of corticosterone-mediated apical dendritic atrophy Rong-Jian Liu and George K. Aghajanian PMCID: PMC2224217 Pharmacology Differential patterning of cGMP in vascular smooth muscle cells revealed by single GFP-linked biosensors Lydia W. M. Nausch, Jonathan Ledoux, Adrian D. Bonev, Mark T. Nelson, and Wolfgang R. Dostmann PMCID: PMC2224218 An alcohol binding site on the neural cell adhesion molecule L1 Enrique Arevalo, Sivananthaperumal Shanmugasundararaj, Michael F. Wilkemeyer, Xiaowei Dou, Suzhen Chen, Michael E. Charness, and Keith W. Miller PMCID: PMC2224219 Physiology The RCK2 domain of the human BKCa channel is a calcium sensor Taleh Yusifov, Nicoletta Savalli, Chris S. Gandhi, Michela Ottolia, and Riccardo Olcese PMCID: PMC2224220 Effect of aging on regional cerebral blood flow responses associated with osmotic thirst and its satiation by water drinking: A PET study M. J. Farrell, F. Zamarripa, R. Shade, P. A. Phillips, M. McKinley, P. T. Fox, J. Blair-West, D. A. Denton, and G. F. Egan PMCID: PMC2224221 Tendons of myostatin-deficient mice are small, brittle, and hypocellular Christopher L. Mendias, Konstantin I. Bakhurin, and John A. Faulkner PMCID: PMC2224222 Psychology Face perception in monkeys reared with no exposure to faces Yoichi Sugita PMCID: PMC2224224 Social Sciences Anthropology Evidence for declines in human population densities during the early Upper Paleolithic in western Europe Eugène Morin PMCID: PMC2224228 Corrections Correction for Rayala et al., Dynamic interplay between nitration and phosphorylation of tubulin cofactor B in the control of microtubule dynamics PMCID: PMC2224225 Corrects: Suresh K. Rayala, et al. Dynamic interplay between nitration and phosphorylation of tubulin cofactor B in the control of microtubule dynamics. Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19470–19475. Correction for Eisenberg et al., Distinctive patterns of microRNA expression in primary muscular disorders PMCID: PMC2224226 Corrects: Iris Eisenberg, et al. Distinctive patterns of microRNA expression in primary muscular disorders. Proc Natl Acad Sci U S A. 2007 October 23; 104(43): 17016–17021. |
