| | This journal provides immediate access to some articles. This Week in PNAS Proc Natl Acad Sci U S A. 2007 August 7; 104(32): 12951–12952. doi: 10.1073/iti3207104.PMCID: PMC1941797 Commentary Coupling distant sites in DNA during DNA mismatch repair Richard D. Kolodner, Marc L. Mendillo, and Christopher D. Putnam PMCID: PMC1941800 Perspective Nobel Lecture The molecular basis of eukaryotic transcription Roger D. Kornberg PMCID: PMC1941834 Physical Sciences Applied Physical Sciences From the Cover:
Reversible atomic processes as basic mechanisms of the glass transition Feng Ye, Wolfgang Sprengel, Rainer K. Wunderlich, Hans-Jörg Fecht, and Hans-Eckhardt Schaefer PMCID: PMC1941791 Dynamic PolyConjugates for targeted in vivo delivery of siRNA to hepatocytes David B. Rozema, David L. Lewis, Darren H. Wakefield, So C. Wong, Jason J. Klein, Paula L. Roesch, Stephanie L. Bertin, Tom W. Reppen, Qili Chu, Andrei V. Blokhin, James E. Hagstrom, and Jon A. Wolff PMCID: PMC1941806 Chemistry Dynamic donor–acceptor [2]catenanes Ognjen Š Miljanić and J. Fraser Stoddart PMCID: PMC1941822 Geology From the Cover:
Prolonged Permian–Triassic ecological crisis recorded by molluscan dominance in Late Permian offshore assemblages Matthew E. Clapham and David J. Bottjer PMCID: PMC1941817 Biological Sciences Agricultural Sciences Disulfooxy fatty acids from the American bird grasshopper Schistocerca americana, elicitors of plant volatiles Hans T. Alborn, Trond V. Hansen, Tappey H. Jones, Derrick C. Bennett, James H. Tumlinson, Eric A. Schmelz, and Peter E. A. Teal PMCID: PMC1941812 Applied Biological Sciences Dynamic PolyConjugates for targeted in vivo delivery of siRNA to hepatocytes David B. Rozema, David L. Lewis, Darren H. Wakefield, So C. Wong, Jason J. Klein, Paula L. Roesch, Stephanie L. Bertin, Tom W. Reppen, Qili Chu, Andrei V. Blokhin, James E. Hagstrom, and Jon A. Wolff PMCID: PMC1941806 Distinct roles of E2F proteins in vascular smooth muscle cell proliferation and intimal hyperplasia Paloma H. Giangrande, JianXin Zhang, Alice Tanner, Andrea D. Eckhart, Rachel E. Rempel, Eran R. Andrechek, Juliana M. Layzer, Janelle R. Keys, Per-Otto Hagen, Joseph R. Nevins, Walter J. Koch, and Bruce A. Sullenger PMCID: PMC1941807 Antifungal hydrogels Andreas Zumbuehl, Lino Ferreira, Duncan Kuhn, Anna Astashkina, Lisa Long, Yoon Yeo, Tiffany Iaconis, Mahmoud Ghannoum, Gerald R. Fink, Robert Langer, and Daniel S. Kohane PMCID: PMC1941801 Biochemistry The GABAA receptor α1 subunit epilepsy mutation A322D inhibits transmembrane helix formation and causes proteasomal degradation Martin J. Gallagher, Li Ding, Ankit Maheshwari, and Robert L. Macdonald PMCID: PMC1941799 Structural basis for reversible photoswitching in Dronpa Martin Andresen, Andre C. Stiel, Simon Trowitzsch, Gert Weber, Christian Eggeling, Markus C. Wahl, Stefan W. Hell, and Stefan Jakobs PMCID: PMC1941826 Assays of vacuole fusion resolve the stages of docking, lipid mixing, and content mixing Youngsoo Jun and William Wickner PMCID: PMC1941832 DNA damage-site recognition by lysine conjugates Boris Breiner, Jörg C. Schlatterer, Igor V. Alabugin, Serguei V. Kovalenko, and Nancy L. Greenbaum PMCID: PMC1941802 Biophysics Intrinsic disorder in the C-terminal domain of the Shaker voltage-activated K+ channel modulates its interaction with scaffold proteins Elhanan Magidovich, Irit Orr, Deborah Fass, Uri Abdu, and Ofer Yifrach PMCID: PMC1941827 Cell Biology Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivation Chi-Hwa Wu, Jan van Riggelen, Alper Yetil, Alice C. Fan, Pavan Bachireddy, and Dean W. Felsher PMCID: PMC1941831 Faithful segregation of the multicopy yeast plasmid through cohesin-mediated recognition of sisters Santanu K. Ghosh, Sujata Hajra, and Makkuni Jayaram PMCID: PMC1941829 HIPK2 represses β-catenin-mediated transcription, epidermal stem cell expansion, and skin tumorigenesis Guangwei Wei, Stephen Ku, Gene K. Ma, Shin'ichi Saito, Amy A. Tang, Jiasheng Zhang, Jian-Hua Mao, Ettore Appella, Allan Balmain, and Eric J. Huang PMCID: PMC1936219 Evolution Chimpanzees are vengeful but not spiteful Keith Jensen, Josep Call, and Michael Tomasello PMCID: PMC1941811 From the Cover:
Natural polymorphism affecting learning and memory in Drosophila Frederic Mery, Amsale T. Belay, Anthony K.-C. So, Marla B. Sokolowski, and Tadeusz J. Kawecki PMCID: PMC1941815 Genetics Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development Dana C. Dolinoy, Dale Huang, and Randy L. Jirtle PMCID: PMC1941790 From the Cover:
Replication and homologous recombination repair regulate DNA double-strand break formation by the antitumor alkylator ecteinascidin 743 Daniele Grazziotin Soares, Alexandre E. Escargueil, Virginie Poindessous, Alain Sarasin, Aimery de Gramont, Diego Bonatto, João Antonio Pêgas Henriques, and Annette K. Larsen PMCID: PMC1941813 TRF2 is required for repair of nontelomeric DNA double-strand breaks by homologous recombination Zhiyong Mao, Andrei Seluanov, Ying Jiang, and Vera Gorbunova PMCID: PMC1941808 Immunology Modification of adverse inflammation is required to cure new-onset type 1 diabetic hosts Maria Koulmanda, Ejona Budo, Susan Bonner-Weir, Andi Qipo, Prabhakar Putheti, Nicolas Degauque, Hang Shi, Zhigang Fan, Jeffrey S. Flier, Hugh Auchincloss, Jr., Xin Xiao Zheng, and Terry B. Strom PMCID: PMC1941818 Solution mapping of T cell receptor docking footprints on peptide-MHC Luca Varani, Alexander J. Bankovich, Corey W. Liu, Leremy A. Colf, Lindsay L. Jones, David M. Kranz, Joseph D. Puglisi, and K. Christopher Garcia PMCID: PMC1941830 Medical Sciences A strategy for predicting the chemosensitivity of human cancers and its application to drug discovery Jae K. Lee, Dmytro M. Havaleshko, HyungJun Cho, John N. Weinstein, Eric P. Kaldjian, John Karpovich, Andrew Grimshaw, and Dan Theodorescu PMCID: PMC1941805 Translational up-regulation of the EGFR by tumor hypoxia provides a nonmutational explanation for its overexpression in human cancer Aleksandra Franovic, Lakshman Gunaratnam, Karlene Smith, Isabelle Robert, David Patten, and Stephen Lee PMCID: PMC1941796 LRH-1-mediated glucocorticoid synthesis in enterocytes protects against inflammatory bowel disease Agnes Coste, Laurent Dubuquoy, Romain Barnouin, Jean-Sebastien Annicotte, Benjamin Magnier, Mario Notti, Nadia Corazza, Maria Cristina Antal, Daniel Metzger, Pierre Desreumaux, Thomas Brunner, Johan Auwerx, and Kristina Schoonjans PMCID: PMC1941823 Existence of transient functional double-stranded DNA intermediates during recombinant AAV transduction Jinhui Wang, Jing Xie, Hui Lu, Lingxia Chen, Bernd Hauck, Richard Jude Samulski, and Weidong Xiao PMCID: PMC1941794 Stable reduction of CCR5 by RNAi through hematopoietic stem cell transplant in non-human primates Dong Sung An, Robert E. Donahue, Masakazu Kamata, Betty Poon, Mark Metzger, Si-Hua Mao, Aylin Bonifacino, Allen E. Krouse, Jean-Luc Darlix, David Baltimore, F. Xiao-Feng Qin, and Irvin S. Y. Chen PMCID: PMC1941789 From the Cover:
Digital PCR for the molecular detection of fetal chromosomal aneuploidy Y. M. Dennis Lo, Fiona M. F. Lun, K. C. Allen Chan, Nancy B. Y. Tsui, Ka C. Chong, Tze K. Lau, Tak Y. Leung, Benny C. Y. Zee, Charles R. Cantor, and Rossa W. K. Chiu PMCID: PMC1934923 Genes overexpressed in different human solid cancers exhibit different tissue-specific expression profiles Jacob Bock Axelsen, Joseph Lotem, Leo Sachs, and Eytan Domany PMCID: PMC1941809 Repression of Six3 by a corepressor regulates rhodopsin expression Bramanandam Manavathi, Shaohua Peng, Suresh K. Rayala, Amjad H. Talukder, Minhua H. Wang, Rui-An Wang, Seetharaman Balasenthil, Neeraj Agarwal, Laura J. Frishman, and Rakesh Kumar PMCID: PMC1941821 The AP1-dependent secretion of galectin-1 by Reed–Sternberg cells fosters immune privilege in classical Hodgkin lymphoma Przemyslaw Juszczynski, Jing Ouyang, Stefano Monti, Scott J. Rodig, Kunihiko Takeyama, Jeremy Abramson, Wen Chen, Jeffery L. Kutok, Gabriel A. Rabinovich, and Margaret A. Shipp PMCID: PMC1936978 Microbiology Random linker-insertion mutagenesis to identify functional domains of herpes simplex virus type 1 glycoprotein B Erick Lin and Patricia G. Spear PMCID: PMC1941792 Long-term maintenance of species-specific bacterial microbiota in the basal metazoan Hydra Sebastian Fraune and Thomas C. G. Bosch PMCID: PMC1934924 Neuroscience Neurotrophins enhance retinal pigment epithelial cell survival through neuroprotectin D1 signaling Pranab K. Mukherjee, Victor L. Marcheselli, Sebastian Barreiro, Jane Hu, Dean Bok, and Nicolas G. Bazan PMCID: PMC1941803 Photoreceptor outer segment phagocytosis attenuates oxidative stress-induced apoptosis with concomitant neuroprotectin D1 synthesis Pranab K. Mukherjee, Victor L. Marcheselli, Juan Carlos de Rivero Vaccari, William C. Gordon, Fannie E. Jackson, and Nicolas G. Bazan PMCID: PMC1941804 Hemodynamic cerebral correlates of sleep spindles during human non-rapid eye movement sleep M. Schabus, T. T. Dang-Vu, G. Albouy, E. Balteau, M. Boly, J. Carrier, A. Darsaud, C. Degueldre, M. Desseilles, S. Gais, C. Phillips, G. Rauchs, C. Schnakers, V. Sterpenich, G. Vandewalle, A. Luxen, and P. Maquet PMCID: PMC1941810 Electrophysiological signatures of resting state networks in the human brain D. Mantini, M. G. Perrucci, C. Del Gratta, G. L. Romani, and M. Corbetta PMCID: PMC1941820 Correlated network activity enhances synaptic efficacy via BDNF and the ERK pathway at immature CA3–CA1 connections in the hippocampus Majid H. Mohajerani, Sudhir Sivakumaran, Paola Zacchi, Pedro Aguilera, and Enrico Cherubini PMCID: PMC1941828 LIM-homeodomain proteins Lhx1 and Lhx5, and their cofactor Ldb1, control Purkinje cell differentiation in the developing cerebellum Yangu Zhao, Kin-Ming Kwan, Christina M. Mailloux, Woon-Kyu Lee, Alexander Grinberg, Wolfgang Wurst, Richard R. Behringer, and Heiner Westphal PMCID: PMC1941824 Quantitative expression profiling of identified neurons reveals cell-specific constraints on highly variable levels of gene expression David J. Schulz, Jean-Marc Goaillard, and Eve E. Marder PMCID: PMC1933263 Pharmacology Three classes of glucocerebrosidase inhibitors identified by quantitative high-throughput screening are chaperone leads for Gaucher disease Wei Zheng, Janak Padia, Daniel J. Urban, Ajit Jadhav, Ozlem Goker-Alpan, Anton Simeonov, Ehud Goldin, Douglas Auld, Mary E. LaMarca, James Inglese, Christopher P. Austin, and Ellen Sidransky PMCID: PMC1936979 Physiology Increase in tracheal investment with beetle size supports hypothesis of oxygen limitation on insect gigantism Alexander Kaiser, C. Jaco Klok, John J. Socha, Wah-Keat Lee, Michael C. Quinlan, and Jon F. Harrison PMCID: PMC1941816 Plant Biology A general model for allometric covariation in botanical form and function Charles A. Price, Brian J. Enquist, and Van M. Savage PMCID: PMC1941814 Social Sciences Psychology Chimpanzees are vengeful but not spiteful Keith Jensen, Josep Call, and Michael Tomasello PMCID: PMC1941811 |
