| | This journal provides immediate access to some articles. This Week in PNAS Proc Natl Acad Sci U S A. 2007 August 14; 104(33): 13211–13212. doi: 10.1073/iti3307104.PMCID: PMC1948942 Commentaries RNA polymerase: The most specific damage recognition protein in cellular responses to DNA damage? Laura A. Lindsey-Boltz and Aziz Sancar PMCID: PMC1948916 Hepatitis C virus–host cell interactions uncovered Judith M. Gottwein and Jens Bukh PMCID: PMC1948903 Economics of Health and Mortality Special Feature Introduction The economics and demography of aging Dora L. Costa PMCID: PMC1948919 Research Articles Race, infection, and arteriosclerosis in the past Dora L. Costa, Lorens A. Helmchen, and Sven Wilson PMCID: PMC1948925 Nature and causes of trends in male diabetes prevalence, undiagnosed diabetes, and the socioeconomic status health gradient James P. Smith PMCID: PMC1948924 From the Cover: Economics of Health and Mortality Special Feature:
Height, health, and development Angus Deaton PMCID: PMC1948943 The shift from defined benefit pensions to 401(k) plans and the pension assets of the baby boom cohort James Poterba, Steven Venti, and David A. Wise PMCID: PMC1948948 Evidence on early-life income and late-life health from America's Dust Bowl era David M. Cutler, Grant Miller, and Douglas M. Norton PMCID: PMC1948901 The economics, technology, and neuroscience of human capability formation James J. Heckman PMCID: PMC1948899 Physical Sciences Applied Physical Sciences Chemotaxis of sperm cells Benjamin M. Friedrich and Frank Jülicher PMCID: PMC1948934 Chemistry Scaffold proteins confer diverse regulatory properties to protein kinase cascades Jason W. Locasale, Andrey S. Shaw, and Arup K. Chakraborty PMCID: PMC1948937 Engineering Primary cilia mediate mechanosensing in bone cells by a calcium-independent mechanism Amanda M. D. Malone, Charles T. Anderson, Padmaja Tummala, Ronald Y. Kwon, Tyler R. Johnston, Tim Stearns, and Christopher R. Jacobs PMCID: PMC1939687 Geology From the Cover:
Fossil genes and microbes in the oldest ice on Earth Kay D. Bidle, SangHoon Lee, David R. Marchant, and Paul G. Falkowski PMCID: PMC1941643 Geophysics From the Cover:
Jet stream intraseasonal oscillations drive dominant ecosystem variations in Oregon's summertime coastal upwelling system John M. Bane, Yvette H. Spitz, Ricardo M. Letelier, and William T. Peterson PMCID: PMC1948897 Sustainability Science Soil erosion and agricultural sustainability David R. Montgomery PMCID: PMC1948917 Biological Sciences Anthropology Dental evidence on the hominin dispersals during the Pleistocene M. Martinón-Torres, J. M. Bermúdez de Castro, A. Gómez-Robles, J. L. Arsuaga, E. Carbonell, D. Lordkipanidze, G. Manzi, and A. Margvelashvili PMCID: PMC1948952 Biochemistry The Btk tyrosine kinase is a major target of the Bcr-Abl inhibitor dasatinib Oliver Hantschel, Uwe Rix, Uwe Schmidt, Tilmann Bürckstümmer, Michael Kneidinger, Gregor Schütze, Jacques Colinge, Keiryn L. Bennett, Wilfried Ellmeier, Peter Valent, and Giulio Superti-Furga PMCID: PMC1940229 Three two-component transporters with channel-like properties have monovalent cation/proton antiport activity Makoto Fujisawa, Masahiro Ito, and Terry A. Krulwich PMCID: PMC1948933 tRNA-modifying MiaE protein from Salmonella typhimurium is a nonheme diiron monooxygenase Carole Mathevon, Fabien Pierrel, Jean-Louis Oddou, Ricardo Garcia-Serres, Geneviève Blondin, Jean-Marc Latour, Stéphane Ménage, Serge Gambarelli, Marc Fontecave, and Mohamed Atta PMCID: PMC1948905 Reconstitution of a human ATR-mediated checkpoint response to damaged DNA Jun-Hyuk Choi, Laura A. Lindsey-Boltz, and Aziz Sancar PMCID: PMC1941640 Biophysics Chemotaxis of sperm cells Benjamin M. Friedrich and Frank Jülicher PMCID: PMC1948934 Scaffold proteins confer diverse regulatory properties to protein kinase cascades Jason W. Locasale, Andrey S. Shaw, and Arup K. Chakraborty PMCID: PMC1948937 Engineering metal ion coordination to regulate amyloid fibril assembly and toxicity Jijun Dong, Jeffrey M. Canfield, Anil K. Mehta, Jacob E. Shokes, Bo Tian, W. Seth Childers, James A. Simmons, Zixu Mao, Robert A. Scott, Kurt Warncke, and David G. Lynn PMCID: PMC1948904 Molecular dioxygen enters the active site of 12/15-lipoxygenase via dynamic oxygen access channels Jan Saam, Igor Ivanov, Matthias Walther, Hermann-Georg Holzhütter, and Hartmut Kuhn PMCID: PMC1948941 Cell Biology Primary cilia mediate mechanosensing in bone cells by a calcium-independent mechanism Amanda M. D. Malone, Charles T. Anderson, Padmaja Tummala, Ronald Y. Kwon, Tyler R. Johnston, Tim Stearns, and Christopher R. Jacobs PMCID: PMC1939687 Nuclear targeting of the growth hormone receptor results in dysregulation of cell proliferation and tumorigenesis Becky L. Conway-Campbell, Jong Wei Wooh, Andrew J. Brooks, David Gordon, Richard J. Brown, Agnieszka M. Lichanska, Hong Soon Chin, Chenoa L. Barton, Glen M. Boyle, Peter G. Parsons, David A. Jans, and Michael J. Waters PMCID: PMC1948913 Moonlighting activity of presenilin in plants is independent of γ-secretase and evolutionarily conserved Abha Khandelwal, Dilip Chandu, Catherine M. Roe, Raphael Kopan, and Ralph S. Quatrano PMCID: PMC1948938 Spatio-temporal analysis of eukaryotic cell motility by improved force cytometry Juan C. del Álamo, Ruedi Meili, Baldomero Alonso-Latorre, Javier Rodríguez-Rodríguez, Alberto Aliseda, Richard A. Firtel, and Juan C. Lasheras PMCID: PMC1940228 Bound attractant at the leading vs. the trailing edge determines chemotactic prowess Paul Herzmark, Kyle Campbell, Fei Wang, Kit Wong, Hana El-Samad, Alex Groisman, and Henry R. Bourne PMCID: PMC1940227 Expression of dominant-negative Dmp53 in the adult fly brain inhibits insulin signaling Johannes H. Bauer, Chengyi Chang, Siti Nur Sarah Morris, Suzanne Hozier, Sandra Andersen, Joshua S. Waitzman, and Stephen L. Helfand PMCID: PMC1948898 Developmental Biology The TrkC receptor induces apoptosis when the dependence receptor notion meets the neurotrophin paradigm Servane Tauszig-Delamasure, Li-Ying Yu, Jorge Ruben Cabrera, Jimena Bouzas-Rodriguez, Catherine Mermet-Bouvier, Catherine Guix, Marie-Claire Bordeaux, Urmas Arumäe, and Patrick Mehlen PMCID: PMC1948910 Local initiation of caspase activation in Drosophila salivary gland programmed cell death in vivo Kiwamu Takemoto, Erina Kuranaga, Ayako Tonoki, Takeharu Nagai, Atsushi Miyawaki, and Masayuki Miura PMCID: PMC1948907 Gtdap-1 promotes autophagy and is required for planarian remodeling during regeneration and starvation Cristina González-Estévez, Daniel A. Felix, Aziz A. Aboobaker, and Emili Saló PMCID: PMC1948951 DNA repair capacity of zebrafish Raquel Sussman PMCID: PMC1948947 Ecology From the Cover:
Jet stream intraseasonal oscillations drive dominant ecosystem variations in Oregon's summertime coastal upwelling system John M. Bane, Yvette H. Spitz, Ricardo M. Letelier, and William T. Peterson PMCID: PMC1948897 Species richness, hotspots, and the scale dependence of range maps in ecology and conservation Allen H. Hurlbert and Walter Jetz PMCID: PMC1948922 Evolution Accumulation of slightly deleterious mutations in mitochondrial protein-coding genes of large versus small mammals Konstantin Popadin, Leonard V. Polishchuk, Leila Mamirova, Dmitry Knorre, and Konstantin Gunbin PMCID: PMC1948928 Genetics Meiotic crossover hotspots contained in haplotype block boundaries of the mouse genome Liisa Kauppi, Maria Jasin, and Scott Keeney PMCID: PMC1948908 Immunology Immune complex-induced enhancement of bacterial antigen presentation requires Fcγ Receptor III expression on dendritic cells Andrés A. Herrada, Francisco J. Contreras, Jaime A. Tobar, Rodrigo Pacheco, and Alexis M. Kalergis PMCID: PMC1948949 IL-8 secreted in a macrophage migration-inhibitory factor- and CD74-dependent manner regulates B cell chronic lymphocytic leukemia survival Inbal Binsky, Michal Haran, Diana Starlets, Yael Gore, Frida Lantner, Nurit Harpaz, Lin Leng, David M. Goldenberg, Lev Shvidel, Alain Berrebi, Richard Bucala, and Idit Shachar PMCID: PMC1948950 Loss of T cell receptor-induced Bmi-1 in the KLRG1+ senescent CD8+ T lymphocyte Maike Heffner and Douglas T. Fearon PMCID: PMC1941641 Decreased expression of Krüppel-like factors in memory B cells induces the rapid response typical of secondary antibody responses Kim L. Good and Stuart G. Tangye PMCID: PMC1948953 A lymphocytic choriomeningitis virus glycoprotein variant that is retained in the endoplasmic reticulum efficiently cross-primes CD8+ T cell responses Stefan Freigang, Bruno Eschli, Nicola Harris, Markus Geuking, Katharina Quirin, Sabrina Schrempf, Raphael Zellweger, Jacqueline Weber, Hans Hengartner, and Rolf M. Zinkernagel PMCID: PMC1948914 Medical Sciences From the Cover:
HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells Catherine Coffinier, Sarah E. Hudon, Emily A. Farber, Sandy Y. Chang, Christine A. Hrycyna, Stephen G. Young, and Loren G. Fong PMCID: PMC1948915 Cholera toxin induces malignant glioma cell differentiation via the PKA/CREB pathway Yan Li, Wei Yin, Xia Wang, Wenbo Zhu, Yijun Huang, and Guangmei Yan PMCID: PMC1940034 Targeting amyloid-β in glaucoma treatment Li Guo, Thomas E. Salt, Vy Luong, Nicholas Wood, William Cheung, Annelie Maass, Giulio Ferrari, Françoise Russo-Marie, Adam M. Sillito, Michael E. Cheetham, Stephen E. Moss, Frederick W. Fitzke, and M. Francesca Cordeiro PMCID: PMC1940230 Oncogenic PIK3CA mutations occur in epidermal nevi and seborrheic keratoses with a characteristic mutation pattern Christian Hafner, Elena López-Knowles, Nuno M. Luis, Agustí Toll, Eulàlia Baselga, Alex Fernández-Casado, Silvia Hernández, Adriana Ribé, Thomas Mentzel, Robert Stoehr, Ferdinand Hofstaedter, Michael Landthaler, Thomas Vogt, Ramòn M. Pujol, Arndt Hartmann, and Francisco X. Real PMCID: PMC1948900 Microbiology From the Cover:
Fossil genes and microbes in the oldest ice on Earth Kay D. Bidle, SangHoon Lee, David R. Marchant, and Paul G. Falkowski PMCID: PMC1941643 Disruption of Plasmodium falciparum development by antibodies against a conserved mosquito midgut antigen Rhoel R. Dinglasan, Dario E. Kalume, Stefan M. Kanzok, Anil K. Ghosh, Olga Muratova, Akhilesh Pandey, and Marcelo Jacobs-Lorena PMCID: PMC1948931 Histone modifications induced by a family of bacterial toxins Mélanie Anne Hamon, Eric Batsché, Béatrice Régnault, To Nam Tham, Stéphanie Seveau, Christian Muchardt, and Pascale Cossart PMCID: PMC1948930 Neuroscience Modulation of NR2B-regulated contextual fear in the hippocampus by the tissue plasminogen activator system Erin H. Norris and Sidney Strickland PMCID: PMC1948906 β-Catenin regulates excitatory postsynaptic strength at hippocampal synapses Takashi Okuda, Lily M. Y. Yu, Lorenzo A. Cingolani, Rolf Kemler, and Yukiko Goda PMCID: PMC1948936 Experience-dependent coding of facial expression in superior temporal sulcus Nicholas Furl, Nicola J. van Rijsbergen, Alessandro Treves, Karl J. Friston, and Raymond J. Dolan PMCID: PMC1948923 On the formation of gamma-coherent cell assemblies by oriens lacunosum-moleculare interneurons in the hippocampus Adriano B. L. Tort, Horacio G. Rotstein, Tamar Dugladze, Tengis Gloveli, and Nancy J. Kopell PMCID: PMC1948921 Quadrantic deficit reveals anatomical constraints on selection Thomas A. Carlson, George A. Alvarez, and Patrick Cavanagh PMCID: PMC1939686 Elevated NMDA receptor levels and enhanced postsynaptic long-term potentiation induced by prenatal exposure to valproic acid Tania Rinaldi, Karina Kulangara, Katia Antoniello, and Henry Markram PMCID: PMC1948920 Development of distinct control networks through segregation and integration Damien A. Fair, Nico U. F. Dosenbach, Jessica A. Church, Alexander L. Cohen, Shefali Brahmbhatt, Francis M. Miezin, Deanna M. Barch, Marcus E. Raichle, Steven E. Petersen, and Bradley L. Schlaggar PMCID: PMC1940033 Pharmacology A miR-24 microRNA binding-site polymorphism in dihydrofolate reductase gene leads to methotrexate resistance Prasun J. Mishra, Rita Humeniuk, Pravin J. Mishra, Giuseppe S. A. Longo-Sorbello, Debabrata Banerjee, and Joseph R. Bertino PMCID: PMC1948927 Physiology 4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1 Marcello Trevisani, Jan Siemens, Serena Materazzi, Diana M. Bautista, Romina Nassini, Barbara Campi, Noritaka Imamachi, Eunice Andrè, Riccardo Patacchini, Graeme S. Cottrell, Raffaele Gatti, Allan I. Basbaum, Nigel W. Bunnett, David Julius, and Pierangelo Geppetti PMCID: PMC1948902 TRPA1 mediates formalin-induced pain Colleen R. McNamara, Josh Mandel-Brehm, Diana M. Bautista, Jan Siemens, Kari L. Deranian, Michael Zhao, Neil J. Hayward, Jayhong A. Chong, David Julius, Magdalene M. Moran, and Christopher M. Fanger PMCID: PMC1941642 Psychology Unsupervised learning of vowel categories from infant-directed speech Gautam K. Vallabha, James L. McClelland, Ferran Pons, Janet F. Werker, and Shigeaki Amano PMCID: PMC1934922 Social Sciences Economic Sciences Race, infection, and arteriosclerosis in the past Dora L. Costa, Lorens A. Helmchen, and Sven Wilson PMCID: PMC1948925 Nature and causes of trends in male diabetes prevalence, undiagnosed diabetes, and the socioeconomic status health gradient James P. Smith PMCID: PMC1948924 From the Cover: Economics of Health and Mortality Special Feature:
Height, health, and development Angus Deaton PMCID: PMC1948943 The shift from defined benefit pensions to 401(k) plans and the pension assets of the baby boom cohort James Poterba, Steven Venti, and David A. Wise PMCID: PMC1948948 Evidence on early-life income and late-life health from America's Dust Bowl era David M. Cutler, Grant Miller, and Douglas M. Norton PMCID: PMC1948901 The economics, technology, and neuroscience of human capability formation James J. Heckman PMCID: PMC1948899 Corrections Correction for Pouvreau et al., Ca2+ sparks operated by membrane depolarization require isoform 3 ryanodine receptor channels in skeletal muscle PMCID: PMC1948935 Corrects: Sandrine Pouvreau, et al. Ca2+ sparks operated by membrane depolarization require isoform 3 ryanodine receptor channels in skeletal muscle. Proc Natl Acad Sci U S A. 2007 March 20; 104(12): 5235–5240. Correction for Lee et al., Root functioning modifies seasonal climate PMCID: PMC1948911 Corrects: Jung-Eun Lee, et al. Root functioning modifies seasonal climate. Proc Natl Acad Sci U S A. 2005 December 6; 102(49): 17576–17581. |
