| | This journal provides immediate access to some articles. Biological Science Plant Biology Arabidopsis SNI1 and RAD51D regulate both gene transcription and DNA recombination during the defense response Wendy E. Durrant, Shui Wang, and Xinnian Dong Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 4223–4227. Published online 2007 February 21. doi: 10.1073/pnas.0609357104.PMCID: PMC1820736 This Week in PNAS Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3669–3670. doi: 10.1073/iti1007104.PMCID: PMC1820638 Commentaries The role of evolution in the invasion process Stephen J. Novak Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3671–3672. Published online 2007 February 28. doi: 10.1073/pnas.0700224104.PMCID: PMC1820639 Meiosis in living color: Fluorescence-based tetrad analysis in Arabidopsis R. Scott Hawley Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3673–3674. Published online 2007 February 28. doi: 10.1073/pnas.0700276104.PMCID: PMC1820640 Biofortification of plant-based food: Enhancing folate levels by metabolic engineering Dean DellaPenna Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3675–3676. Published online 2007 March 5. doi: 10.1073/pnas.0700640104.PMCID: PMC1820641 Physical Sciences Applied Mathematics Mathematical modeling of cell population dynamics in the colonic crypt and in colorectal cancer Matthew D. Johnston, Carina M. Edwards, Walter F. Bodmer, Philip K. Maini, and S. Jonathan Chapman Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 4008–4013. Published online 2007 February 28. doi: 10.1073/pnas.0611179104.PMCID: PMC1820699 Applied Physical Sciences Predicting response to breast cancer neoadjuvant chemotherapy using diffuse optical spectroscopy Albert Cerussi, David Hsiang, Natasha Shah, Rita Mehta, Amanda Durkin, John Butler, and Bruce J. Tromberg Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 4014–4019. Published online 2007 February 28. doi: 10.1073/pnas.0611058104.PMCID: PMC1805697 Chemistry Antibody-catalyzed anaerobic destruction of methamphetamine Yang Xu, Mark S. Hixon, Noboru Yamamoto, Laura A. McAllister, Anita D. Wentworth, Paul Wentworth, Jr., and Kim D. Janda Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3681–3686. Published online 2007 February 28. doi: 10.1073/pnas.0611094104.PMCID: PMC1820643 Electrostatic gating of a nanometer water channel Jingyuan Li, Xiaojing Gong, Hangjun Lu, Ding Li, Haiping Fang, and Ruhong Zhou Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3687–3692. Published online 2007 February 27. doi: 10.1073/pnas.0604541104.PMCID: PMC1820644 A hexahistidine-Zn2+-dye label reveals STIM1 surface exposure Christina T. Hauser and Roger Y. Tsien Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3693–3697. Published online 2007 February 28. doi: 10.1073/pnas.0611713104.PMCID: PMC1805700 Mechanism of metal-independent decomposition of organic hydroperoxides and formation of alkoxyl radicals by halogenated quinones Ben-Zhan Zhu, Hong-Tao Zhao, Balaraman Kalyanaraman, Jun Liu, Guo-Qiang Shan, Yu-Guo Du, and Balz Frei Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3698–3702. Published online 2007 February 28. doi: 10.1073/pnas.0605527104.PMCID: PMC1820646 Gallium (III) triflate catalyzed efficient Strecker reaction of ketones and their fluorinated analogs G. K. Surya Prakash, Thomas Mathew, Chiradeep Panja, Steevens Alconcel, Habiba Vaghoo, Clement Do, and George A. Olah Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3703–3706. Published online 2007 February 28. doi: 10.1073/pnas.0611316104.PMCID: PMC1820647 Scanning tunneling microscopy of the formation, transformation, and property of oligothiophene self-organizations on graphite and gold surfaces Zhi-Yong Yang, Hui-Min Zhang, Cun-Ji Yan, Shan-Shan Li, Hui-Juan Yan, Wei-Guo Song, and Li-Jun Wan Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3707–3712. Published online 2007 February 28. doi: 10.1073/pnas.0611585104.PMCID: PMC1820648 Environmental Sciences Solar influence on climate during the past millennium: Results from transient simulations with the NCAR Climate System Model Caspar M. Ammann, Fortunat Joos, David S. Schimel, Bette L. Otto-Bliesner, and Robert A. Tomas Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3713–3718. Published online 2007 March 5. doi: 10.1073/pnas.0605064103.PMCID: PMC1810336 Geophysics Delayed upwelling alters nearshore coastal ocean ecosystems in the northern California current John A. Barth, Bruce A. Menge, Jane Lubchenco, Francis Chan, John M. Bane, Anthony R. Kirincich, Margaret A. McManus, Karina J. Nielsen, Stephen D. Pierce, and Libe Washburn Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3719–3724. Published online 2007 February 27. doi: 10.1073/pnas.0700462104.PMCID: PMC1805484 Mathematics Lifting cusp forms to Maass forms with an application to partitions Kathrin Bringmann and Ken Ono Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3725–3731. Published online 2007 February 28. doi: 10.1073/pnas.0611414104.PMCID: PMC1820651 Physics INAUGURAL ARTICLE by a Recently Elected Academy Member: Experiments with probe masses V. B. Braginsky Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3677–3680. Published online 2007 February 12. doi: 10.1073/pnas.0610311104.PMCID: PMC1820642 Unified picture of the oxygen isotope effect in cuprate superconductors Xiao-Jia Chen, Viktor V. Struzhkin, Zhigang Wu, Hai-Qing Lin, Russell J. Hemley, and Ho-kwang Mao Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3732–3735. Published online 2007 February 26. doi: 10.1073/pnas.0611473104.PMCID: PMC1820652 On the mechanism of wing size determination in fly development Lars Hufnagel, Aurelio A. Teleman, Hervé Rouault, Stephen M. Cohen, and Boris I. Shraiman Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3835–3840. Published online 2007 February 28. doi: 10.1073/pnas.0607134104.PMCID: PMC1820670 Biological Sciences Anthropology Absence of the lactase-persistence-associated allele in early Neolithic Europeans J. Burger, M. Kirchner, B. Bramanti, W. Haak, and M. G. Thomas Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3736–3741. Published online 2007 February 28. doi: 10.1073/pnas.0607187104.PMCID: PMC1820653 Applied Biological Sciences RNA aptamers directed to discrete functional sites on a single protein structural domain Hua Shi, Xiaochun Fan, Aarti Sevilimedu, and John T. Lis Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3742–3746. Published online 2007 February 28. doi: 10.1073/pnas.0607805104.PMCID: PMC1820654 Induction of the celC operon of Clostridium thermocellum by laminaribiose Michael Newcomb, Chun-Yu Chen, and J. H. David Wu Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3747–3752. Published online 2007 February 27. doi: 10.1073/pnas.0700087104.PMCID: PMC1820655 Biochemistry Antibody-catalyzed anaerobic destruction of methamphetamine Yang Xu, Mark S. Hixon, Noboru Yamamoto, Laura A. McAllister, Anita D. Wentworth, Paul Wentworth, Jr., and Kim D. Janda Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3681–3686. Published online 2007 February 28. doi: 10.1073/pnas.0611094104.PMCID: PMC1820643 Mechanism for inactivation of the mitotic inhibitory kinase Wee1 at M phase Kengo Okamoto and Noriyuki Sagata Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3753–3758. Published online 2007 February 23. doi: 10.1073/pnas.0607357104.PMCID: PMC1820656 Structures of the extracellular regions of the group II/III metabotropic glutamate receptors Takanori Muto, Daisuke Tsuchiya, Kosuke Morikawa, and Hisato Jingami Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3759–3764. Published online 2007 February 26. doi: 10.1073/pnas.0611577104.PMCID: PMC1820657 Regulation of poly(ADP-ribose) polymerase 1 activity by the phosphorylation state of the nuclear NAD biosynthetic enzyme NMN adenylyl transferase 1 Felicitas Berger, Corinna Lau, and Mathias Ziegler Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3765–3770. Published online 2007 February 22. doi: 10.1073/pnas.0609211104.PMCID: PMC1820658 Inhibition of regulated proteolysis by RseB Brent O. Cezairliyan and Robert T. Sauer Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3771–3776. Published online 2007 February 26. doi: 10.1073/pnas.0611567104.PMCID: PMC1820659 Biophysics Electrostatic gating of a nanometer water channel Jingyuan Li, Xiaojing Gong, Hangjun Lu, Ding Li, Haiping Fang, and Ruhong Zhou Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3687–3692. Published online 2007 February 27. doi: 10.1073/pnas.0604541104.PMCID: PMC1820644 Direct visualization of Escherichia coli chemotaxis receptor arrays using cryo-electron microscopy Peijun Zhang, Cezar M. Khursigara, Lisa M. Hartnell, and Sriram Subramaniam Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3777–3781. Published online 2007 February 26. doi: 10.1073/pnas.0610106104.PMCID: PMC1820660 Adhesion mechanisms of the mussel foot proteins mfp-1 and mfp-3 Qi Lin, Delphine Gourdon, Chengjun Sun, Niels Holten-Andersen, Travers H. Anderson, J. Herbert Waite, and Jacob N. Israelachvili Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3782–3786. Published online 2007 February 28. doi: 10.1073/pnas.0607852104.PMCID: PMC1820661 Cell Biology A hexahistidine-Zn2+-dye label reveals STIM1 surface exposure Christina T. Hauser and Roger Y. Tsien Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3693–3697. Published online 2007 February 28. doi: 10.1073/pnas.0611713104.PMCID: PMC1805700 Functional role and oncogene-regulated expression of the BH3-only factor Bmf in mammary epithelial anoikis and morphogenesis Tobias Schmelzle, Arnaud A. Mailleux, Michael Overholtzer, Jason S. Carroll, Nicole L. Solimini, Eric S. Lightcap, Ole P. Veiby, and Joan S. Brugge Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3787–3792. Published online 2007 February 26. doi: 10.1073/pnas.0700115104.PMCID: PMC1820662 Loss of endocytic clathrin-coated pits upon acute depletion of phosphatidylinositol 4,5-bisphosphate Roberto Zoncu, Rushika M. Perera, Rafael Sebastian, Fubito Nakatsu, Hong Chen, Tamas Balla, Guillermo Ayala, Derek Toomre, and Pietro V. De Camilli Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3793–3798. Published online 2007 February 27. doi: 10.1073/pnas.0611733104.PMCID: PMC1805489 Trophoblast cell activation by trophinin ligation is implicated in human embryo implantation Kazuhiro Sugihara, Daijiro Sugiyama, James Byrne, Don P. Wolf, Kevin P. Lowitz, Yoichi Kobayashi, Maryam Kabir-Salmani, Daita Nadano, Daisuke Aoki, Shiro Nozawa, Jun Nakayama, Tomas Mustelin, Erkki Ruoslahti, Naoto Yamaguchi, and Michiko N. Fukuda Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3799–3804. Published online 2007 February 26. doi: 10.1073/pnas.0611516104.PMCID: PMC1805454 Cross-talk between Chk1 and Chk2 in double-mutant thymocytes Kathrin Zaugg, Yu-Wen Su, Patrick T. Reilly, Yasmin Moolani, Carol C. Cheung, Razquallah Hakem, Atsushi Hirao, Quinghua Liu, Stephen J. Elledge, and Tak W. Mak Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3805–3810. Published online 2007 February 26. doi: 10.1073/pnas.0611584104.PMCID: PMC1820665 Cell-cycle-dependent phosphorylation of the nuclear pore Nup107–160 subcomplex Joseph S. Glavy, Andrew N. Krutchinsky, Ileana M. Cristea, Ian C. Berke, Thomas Boehmer, Günter Blobel, and Brian T. Chait Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3811–3816. Published online 2007 February 28. doi: 10.1073/pnas.0700058104.PMCID: PMC1820666 Heterotrimeric G protein signaling in the Arabidopsis unfolded protein response Shiyu Wang, Savitha Narendra, and Nina Fedoroff Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3817–3822. Published online 2007 February 28. doi: 10.1073/pnas.0611735104.PMCID: PMC1820667 E-Syts, a family of membranous Ca2+-sensor proteins with multiple C2 domains Sang-Won Min, Wen-Pin Chang, and Thomas C. Südhof Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3823–3828. Published online 2007 February 28. doi: 10.1073/pnas.0611725104.PMCID: PMC1820668 c-Myb is required for progenitor cell homeostasis in colonic crypts Jordane Malaterre, Marina Carpinelli, Matthias Ernst, Warren Alexander, Michael Cooke, Susan Sutton, Sebastian Dworkin, Joan K. Heath, Jon Frampton, Grant McArthur, Hans Clevers, Douglas Hilton, Theo Mantamadiotis, and Robert G. Ramsay Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3829–3834. Published online 2007 February 26. doi: 10.1073/pnas.0610055104.PMCID: PMC1820669 Developmental Biology On the mechanism of wing size determination in fly development Lars Hufnagel, Aurelio A. Teleman, Hervé Rouault, Stephen M. Cohen, and Boris I. Shraiman Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3835–3840. Published online 2007 February 28. doi: 10.1073/pnas.0607134104.PMCID: PMC1820670 C-type natriuretic peptide regulates blood–testis barrier dynamics in adult rat testes Weiliang Xia, Dolores D. Mruk, and C. Yan Cheng Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3841–3846. Published online 2007 February 27. doi: 10.1073/pnas.0610100104.PMCID: PMC1820671 Linking pattern formation to cell-type specification: Dichaete and Ind directly repress achaete gene expression in the Drosophila CNS Guoyan Zhao, Grace Boekhoff-Falk, Beth A. Wilson, and James B. Skeath Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3847–3852. Published online 2007 February 26. doi: 10.1073/pnas.0611700104.PMCID: PMC1820672 MafB is required for islet β cell maturation Isabella Artner, Bruno Blanchi, Jeffrey C. Raum, Min Guo, Tomomi Kaneko, Sabine Cordes, Michael Sieweke, and Roland Stein Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3853–3858. Published online 2007 February 22. doi: 10.1073/pnas.0700013104.PMCID: PMC1803762 Sox17 is essential for the specification of cardiac mesoderm in embryonic stem cells Yu Liu, Masanori Asakura, Hironori Inoue, Teruya Nakamura, Motoaki Sano, Zhiyv Niu, Michelle Chen, Robert J. Schwartz, and Michael D. Schneider Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3859–3864. Published online 2007 February 28. doi: 10.1073/pnas.0609100104.PMCID: PMC1820674 DMY gene induces male development in genetically female (XX) medaka fish Masaru Matsuda, Ai Shinomiya, Masato Kinoshita, Aya Suzuki, Tohru Kobayashi, Bindhu Paul-Prasanth, En-lieng Lau, Satoshi Hamaguchi, Mitsuru Sakaizumi, and Yoshitaka Nagahama Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3865–3870. Published online 2007 February 28. doi: 10.1073/pnas.0611707104.PMCID: PMC1820675 Interaction with the mammary microenvironment redirects spermatogenic cell fate in vivo Corinne A. Boulanger, David L. Mack, Brian W. Booth, and Gilbert H. Smith Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3871–3876. Published online 2007 February 28. doi: 10.1073/pnas.0611637104.PMCID: PMC1820676 Mechanisms controlling the acquisition of a cardiac phenotype by liver stem cells Barbara J. Muller-Borer, Wayne E. Cascio, Gwyn L. Esch, Hyung-Suk Kim, William B. Coleman, Joe W. Grisham, Page A. W. Anderson, and Nadia N. Malouf Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3877–3882. Published online 2007 February 26. doi: 10.1073/pnas.0700416104.PMCID: PMC1805456 Ecology Delayed upwelling alters nearshore coastal ocean ecosystems in the northern California current John A. Barth, Bruce A. Menge, Jane Lubchenco, Francis Chan, John M. Bane, Anthony R. Kirincich, Margaret A. McManus, Karina J. Nielsen, Stephen D. Pierce, and Libe Washburn Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3719–3724. Published online 2007 February 27. doi: 10.1073/pnas.0700462104.PMCID: PMC1805484 From the Cover: Increased genetic variation and evolutionary potential drive the success of an invasive grass Sébastien Lavergne and Jane Molofsky Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3883–3888. Published online 2007 February 28. doi: 10.1073/pnas.0607324104.PMCID: PMC1805698 Gene–environment interactions influence ecological consequences of transgenic animals L. F. Sundström, M. Lõhmus, W. E. Tymchuk, and Robert H. Devlin Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3889–3894. Published online 2007 February 27. doi: 10.1073/pnas.0608767104.PMCID: PMC1820679 Environmental Sciences Chlorination of lignin by ubiquitous fungi has a likely role in global organochlorine production Patricia Ortiz-Bermúdez, Kolby C. Hirth, Ewald Srebotnik, and Kenneth E. Hammel Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3895–3900. Published online 2007 February 26. doi: 10.1073/pnas.0610074104.PMCID: PMC1820680 Evolution From the Cover: Prospects for fungus identification using CO1 DNA barcodes, with Penicillium as a test case Keith A. Seifert, Robert A. Samson, Jeremy R. deWaard, Jos Houbraken, C. André Lévesque, Jean-Marc Moncalvo, Gerry Louis-Seize, and Paul D. N. Hebert Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3901–3906. Published online 2007 February 28. doi: 10.1073/pnas.0611691104.PMCID: PMC1805696 Adaptive evolution in humans revealed by the negative correlation between the polymorphism and fixation phases of evolution Jun Gojobori, Hua Tang, Joshua M. Akey, and Chung-I Wu Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3907–3912. Published online 2007 February 26. doi: 10.1073/pnas.0605565104.PMCID: PMC1820682 Genetics From the Cover: Pollen tetrad-based visual assay for meiotic recombination in Arabidopsis Kirk E. Francis, Sandy Y. Lam, Benjamin D. Harrison, Alexandra L. Bey, Luke E. Berchowitz, and Gregory P. Copenhaver Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3913–3918. Published online 2007 February 23. doi: 10.1073/pnas.0608936104.PMCID: PMC1805420 Filamin B deficiency in mice results in skeletal malformations and impaired microvascular development Xianghua Zhou, Fei Tian, Johan Sandzén, Renhai Cao, Emilie Flaberg, Laszlo Szekely, Yihai Cao, Claes Ohlsson, Martin O. Bergo, Jan Borén, and Levent M. Akyürek Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3919–3924. Published online 2007 February 26. doi: 10.1073/pnas.0608360104.PMCID: PMC1820684 Systematic genome instability screens in yeast and their potential relevance to cancer Karen W. Y. Yuen, Cheryl D. Warren, Ou Chen, Teresa Kwok, Phil Hieter, and Forrest A. Spencer Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3925–3930. Published online 2007 February 28. doi: 10.1073/pnas.0610642104.PMCID: PMC1820685 Ink4a/Arf tumor suppressor does not modulate the degenerative conditions or tumor spectrum of the telomerase-deficient mouse Christine M. Khoo, Daniel R. Carrasco, Marcus W. Bosenberg, Ji-Hye Paik, and Ronald A. DePinho Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3931–3936. Published online 2007 February 27. doi: 10.1073/pnas.0700093104.PMCID: PMC1820686 Skeletal overgrowth is mediated by deficiency in a specific isoform of fibroblast growth factor receptor 3 Veraragavan P. Eswarakumar and Joseph Schlessinger Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3937–3942. Published online 2007 February 23. doi: 10.1073/pnas.0700012104.PMCID: PMC1820687 KCNQ potassium channel mutations cause cardiac arrhythmias in Drosophila that mimic the effects of aging Karen Ocorr, Nick L. Reeves, Robert J. Wessells, Martin Fink, H.-S. Vincent Chen, Takeshi Akasaka, Soichiro Yasuda, Joseph M. Metzger, Wayne Giles, James W. Posakony, and Rolf Bodmer Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3943–3948. Published online 2007 February 28. doi: 10.1073/pnas.0609278104.PMCID: PMC1820688 Targeted deletion of Wwox reveals a tumor suppressor function Rami I. Aqeilan, Francesco Trapasso, Sadiq Hussain, Stefan Costinean, Dean Marshall, Yuri Pekarsky, John P. Hagan, Nicola Zanesi, Mohamed Kaou, Gary S. Stein, Jane B. Lian, and Carlo M. Croce Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3949–3954. Published online 2007 February 27. doi: 10.1073/pnas.0609783104.PMCID: PMC1820689 Loss of a histone deacetylase dramatically alters the genomic distribution of Spo11p-catalyzed DNA breaks in Saccharomyces cerevisiae Piotr A. Mieczkowski, Margaret Dominska, Michael J. Buck, Jason D. Lieb, and Thomas D. Petes Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3955–3960. Published online 2007 February 28. doi: 10.1073/pnas.0700412104.PMCID: PMC1805699 Association of a common complement receptor 2 haplotype with increased risk of systemic lupus erythematosus Hui Wu, Susan A. Boackle, Punchong Hanvivadhanakul, Daniela Ulgiati, Jennifer M. Grossman, Youngho Lee, Nan Shen, Lawrence J. Abraham, Timothy R. Mercer, Elly Park, Lee A. Hebert, Brad H. Rovin, Dan J. Birmingham, Deh-Ming Chang, Chung Jen Chen, Deborah McCurdy, Humeira M. Badsha, Bernard Y. H. Thong, Hiok H. Chng, Frank C. Arnett, Daniel J. Wallace, C. Yung Yu, Bevra H. Hahn, Rita M. Cantor, and Betty P. Tsao Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3961–3966. Published online 2007 February 22. doi: 10.1073/pnas.0609101104.PMCID: PMC1820691 Immunology CD8 tumor-infiltrating lymphocytes are predictive of survival in muscle-invasive urothelial carcinoma Padmanee Sharma, Yu Shen, Sijin Wen, Sachiko Yamada, Achim A. Jungbluth, Sacha Gnjatic, Dean F. Bajorin, Victor E. Reuter, Harry Herr, Lloyd J. Old, and Eiichi Sato Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3967–3972. Published online 2007 February 27. doi: 10.1073/pnas.0611618104.PMCID: PMC1820692 Innate response to self-antigen significantly exacerbates burn wound depth Freeman Suber, Michael C. Carroll, and Francis D. Moore, Jr. Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3973–3977. Published online 2007 February 28. doi: 10.1073/pnas.0609026104.PMCID: PMC1820693 Stable masking by H-2Dd cis ligand limits Ly49A relocalization to the site of NK cell/target cell contact Jonathan Back, Anick Chalifour, Léonardo Scarpellino, and Werner Held Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3978–3983. Published online 2007 February 26. doi: 10.1073/pnas.0607418104.PMCID: PMC1820694 Invariant NKT cells sustain specific B cell responses and memory Grazia Galli, Paola Pittoni, Elena Tonti, Carmine Malzone, Yasushi Uematsu, Marco Tortoli, Domenico Maione, Gianfranco Volpini, Oretta Finco, Sandra Nuti, Simona Tavarini, Paolo Dellabona, Rino Rappuoli, Giulia Casorati, and Sergio Abrignani Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3984–3989. Published online 2007 February 27. doi: 10.1073/pnas.0700191104.PMCID: PMC1805488 Immunotherapeutic activity of a conjugate of a Toll-like receptor 7 ligand Christina C. N. Wu, Tomoko Hayashi, Kenji Takabayashi, Mojgan Sabet, Donald F. Smee, Donald D. Guiney, Howard B. Cottam, and Dennis A. Carson Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3990–3995. Published online 2007 February 21. doi: 10.1073/pnas.0611624104.PMCID: PMC1820696 From the Cover: Endogenous IL-12 triggers an antiangiogenic program in melanoma cells Irma Airoldi, Emma Di Carlo, Claudia Cocco, Giuseppe Taverniti, Tommaso D'Antuono, Emanuela Ognio, Morihiro Watanabe, Domenico Ribatti, and Vito Pistoia Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 3996–4001. Published online 2007 February 23. doi: 10.1073/pnas.0609028104.PMCID: PMC1820697 Restriction of endogenous T cell antigen receptor β rearrangements to Vβ14 through selective recombination signal sequence modifications Cherry Wu, Sheila Ranganath, Megan Gleason, Barbara B. Woodman, Tiffany M. Borjeson, Frederick W. Alt, and Craig H. Bassing Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 4002–4007. Published online 2007 February 27. doi: 10.1073/pnas.0700081104.PMCID: PMC1820698 Medical Sciences Mathematical modeling of cell population dynamics in the colonic crypt and in colorectal cancer Matthew D. Johnston, Carina M. Edwards, Walter F. Bodmer, Philip K. Maini, and S. Jonathan Chapman Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 4008–4013. Published online 2007 February 28. doi: 10.1073/pnas.0611179104.PMCID: PMC1820699 Predicting response to breast cancer neoadjuvant chemotherapy using diffuse optical spectroscopy Albert Cerussi, David Hsiang, Natasha Shah, Rita Mehta, Amanda Durkin, John Butler, and Bruce J. Tromberg Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 4014–4019. Published online 2007 February 28. doi: 10.1073/pnas.0611058104.PMCID: PMC1805697 WNK4 regulates activity of the epithelial Na+ channel in vitro and in vivo Aaron M. Ring, Sam X. Cheng, Qiang Leng, Kristopher T. Kahle, Jesse Rinehart, Maria D. Lalioti, Heather M. Volkman, Frederick H. Wilson, Steven C. Hebert, and Richard P. Lifton Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 4020–4024. Published online 2007 February 26. doi: 10.1073/pnas.0611727104.PMCID: PMC1805455 An SGK1 site in WNK4 regulates Na+ channel and K+ channel activity and has implications for aldosterone signaling and K+ homeostasis Aaron M. Ring, Qiang Leng, Jesse Rinehart, Frederick H. Wilson, Kristopher T. Kahle, Steven C. Hebert, and Richard P. Lifton Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 4025–4029. Published online 2007 February 22. doi: 10.1073/pnas.0611728104.PMCID: PMC1803763 Fusion of proinsulin-producing bone marrow-derived cells with hepatocytes in diabetes Mineko Fujimiya, Hideto Kojima, Masumi Ichinose, Ryohachi Arai, Hiroshi Kimura, Atsunori Kashiwagi, and Lawrence Chan Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 4030–4035. Published online 2007 February 27. doi: 10.1073/pnas.0700220104.PMCID: PMC1820703 A target-selected Apc-mutant rat kindred enhances the modeling of familial human colon cancer James M. Amos-Landgraf, Lawrence N. Kwong, Christina M. Kendziorski, Mark Reichelderfer, Jose Torrealba, Jamey Weichert, Jill D. Haag, Kai-Shun Chen, Jordy L. Waller, Michael N. Gould, and William F. Dove Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 4036–4041. Published online 2007 February 27. doi: 10.1073/pnas.0611690104.PMCID: PMC1805486 Spatial navigation deficit in amnestic mild cognitive impairment Jakub Hort, Jan Laczó, Martin Vyhnálek, Martin Bojar, Jan Bureš, and Kamil Vlček Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 4042–4047. Published online 2007 February 28. doi: 10.1073/pnas.0611314104.PMCID: PMC1820705 Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma Craig D. Peacock, Qiuju Wang, Gregory S. Gesell, Ian M. Corcoran-Schwartz, Evan Jones, Jynho Kim, Wendy L. Devereux, Jonathan T. Rhodes, Carol A. Huff, Philip A. Beachy, D. Neil Watkins, and William Matsui Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 4048–4053. Published online 2007 February 27. doi: 10.1073/pnas.0611682104.PMCID: PMC1805487 The nuclear function of p53 is required for PUMA-mediated apoptosis induced by DNA damage Peng Wang, Jian Yu, and Lin Zhang Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 4054–4059. Published online 2007 February 28. doi: 10.1073/pnas.0700020104.PMCID: PMC1820707 Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T Xiaodong Zhang, Ailan Guo, Jianshi Yu, Anthony Possemato, Yueting Chen, Weiping Zheng, Roberto D. Polakiewicz, Kenneth W. Kinzler, Bert Vogelstein, Victor E. Velculescu, and Zhenghe John Wang Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 4060–4064. Published online 2007 February 21. doi: 10.1073/pnas.0611665104.PMCID: PMC1802729 Steroid receptor coactivator 3 is a coactivator for myocardin, the regulator of smooth muscle transcription and differentiation Hui Joyce Li, Zaffar Haque, Qing Lu, Li Li, Richard Karas, and Michael Mendelsohn Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 4065–4070. Published online 2007 February 28. doi: 10.1073/pnas.0611639104.PMCID: PMC1820709 A phase I clinical trial with monoclonal antibody ch806 targeting transitional state and mutant epidermal growth factor receptors Andrew M. Scott, Fook-Thean Lee, Niall Tebbutt, Rebecca Herbertson, Sanjeev S. Gill, Zhanqi Liu, Effie Skrinos, Carmel Murone, Timothy H. Saunder, Bridget Chappell, Anthony T. Papenfuss, Aurora M. T. Poon, Wendie Hopkins, Fiona E. Smyth, Duncan MacGregor, Lawrence M. Cher, Achim A. Jungbluth, Gerd Ritter, Martin W. Brechbiel, Roger Murphy, Antony W. Burgess, Eric W. Hoffman, Terrance G. Johns, and Lloyd J. Old Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 4071–4076. Published online 2007 February 28. doi: 10.1073/pnas.0611693104.PMCID: PMC1805701 α-Lipoic acid attenuates LPS-induced inflammatory responses by activating the phosphoinositide 3-kinase/Akt signaling pathway Wei-Jian Zhang, Hao Wei, Tory Hagen, and Balz Frei Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 4077–4082. Published online 2007 February 27. doi: 10.1073/pnas.0700305104.PMCID: PMC1805485 Adenosine regulation of alveolar fluid clearance Phillip Factor, Göskhan M. Mutlu, Lan Chen, Jameel Mohameed, Alexander T. Akhmedov, Fan Jing Meng, Tamas Jilling, Erin Rachel Lewis, Meshell D. Johnson, Anna Xu, Daniel Kass, Janice M. Martino, Amy Bellmeyer, John S. Albazi, Charles Emala, H. T. Lee, Leland G. Dobbs, and Sadis Matalon Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 4083–4088. Published online 2007 February 28. doi: 10.1073/pnas.0601117104.PMCID: PMC1820712 Transgenic cyclin E triggers dysplasia and multiple pulmonary adenocarcinomas Yan Ma, Steven Fiering, Candice Black, Xi Liu, Ziqiang Yuan, Vincent A. Memoli, David J. Robbins, Heather A. Bentley, Gregory J. Tsongalis, Eugene Demidenko, Sarah J. Freemantle, and Ethan Dmitrovsky Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 4089–4094. Published online 2007 February 27. doi: 10.1073/pnas.0606537104.PMCID: PMC1820713 Selective gene silencing in activated leukocytes by targeting siRNAs to the integrin lymphocyte function-associated antigen-1 Dan Peer, Pengcheng Zhu, Christopher V. Carman, Judy Lieberman, and Motomu Shimaoka Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 4095–4100. Published online 2007 February 28. doi: 10.1073/pnas.0608491104.PMCID: PMC1820714 Molecular diagnosis of pituitary adenoma predisposition caused by aryl hydrocarbon receptor-interacting protein gene mutations Marianthi Georgitsi, Anniina Raitila, Auli Karhu, Karoliina Tuppurainen, Markus J. Mäkinen, Outi Vierimaa, Ralf Paschke, Wolfgang Saeger, Rob B. van der Luijt, Timo Sane, Mercedes Robledo, Ernesto De Menis, Robert J. Weil, Anna Wasik, Grzegorz Zielinski, Olga Lucewicz, Jan Lubinski, Virpi Launonen, Pia Vahteristo, and Lauri A. Aaltonen Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 4101–4105. Published online 2007 February 28. doi: 10.1073/pnas.0700004104.PMCID: PMC1820715 Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase Mark G. Manfredi, Jeffrey A. Ecsedy, Kristan A. Meetze, Suresh K. Balani, Olga Burenkova, Wei Chen, Katherine M. Galvin, Kara M. Hoar, Jessica J. Huck, Patrick J. LeRoy, Emily T. Ray, Todd B. Sells, Bradley Stringer, Stephen G. Stroud, Tricia J. Vos, Gabriel S. Weatherhead, Deborah R. Wysong, Mengkun Zhang, Joseph B. Bolen, and Christopher F. Claiborne Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 4106–4111. Published online 2007 February 23. doi: 10.1073/pnas.0608798104.PMCID: PMC1820716 Microbiology DgrA is a member of a new family of cyclic diguanosine monophosphate receptors and controls flagellar motor function in Caulobacter crescentus Matthias Christen, Beat Christen, Martin G. Allan, Marc Folcher, Paul Jenö, Stephan Grzesiek, and Urs Jenal Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 4112–4117. Published online 2007 February 27. doi: 10.1073/pnas.0607738104.PMCID: PMC1805490 Distinct roles of haptoglobin-related protein and apolipoprotein L-I in trypanolysis by human serum Benoit Vanhollebeke, Marianne J. Nielsen, Yoshihisa Watanabe, Philippe Truc, Luc Vanhamme, Kazunori Nakajima, Soren K. Moestrup, and Etienne Pays Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 4118–4123. Published online 2007 February 26. doi: 10.1073/pnas.0609902104.PMCID: PMC1820718 Escherichia coli enzyme IIANtr regulates the K+ transporter TrkA Chang-Ro Lee, Seung-Hyon Cho, Mi-Jeong Yoon, Alan Peterkofsky, and Yeong-Jae Seok Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 4124–4129. Published online 2007 February 8. doi: 10.1073/pnas.0609897104.PMCID: PMC1794712 HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1 Bärbel Schröfelbauer, Yoshiyuki Hakata, and Nathaniel R. Landau Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 4130–4135. Published online 2007 February 28. doi: 10.1073/pnas.0610167104.PMCID: PMC1820720 Attenuated virulence of a Francisella mutant lacking the lipid A 4′-phosphatase Xiaoyuan Wang, Anthony A. Ribeiro, Ziqiang Guan, Soman N. Abraham, and Christian R. H. Raetz Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 4136–4141. Published online 2007 February 26. doi: 10.1073/pnas.0611606104.PMCID: PMC1820721 Separation of receptor-binding and profusogenic domains of glycoprotein D of herpes simplex virus 1 into distinct interacting proteins Guoying Zhou and Bernard Roizman Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 4142–4146. Published online 2007 February 27. doi: 10.1073/pnas.0611565104.PMCID: PMC1820722 Neuroscience Inhibition of Cdk5 in the nucleus accumbens enhances the locomotor-activating and incentive-motivational effects of cocaine Jane R. Taylor, Wendy J. Lynch, Hayde Sanchez, Peter Olausson, Eric J. Nestler, and James A. Bibb Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 4147–4152. Published online 2007 February 23. doi: 10.1073/pnas.0610288104.PMCID: PMC1820723 Cortical area size dictates performance at modality-specific behaviors Axel Leingärtner, Sandrine Thuret, Todd T. Kroll, Shen-Ju Chou, J. Leigh Leasure, Fred H. Gage, and Dennis D. M. O'Leary Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 4153–4158. Published online 2007 February 27. doi: 10.1073/pnas.0611723104.PMCID: PMC1820724 Regulation of Alzheimer's disease amyloid-β formation by casein kinase I Marc Flajolet, Gen He, Myriam Heiman, Angie Lin, Angus C. Nairn, and Paul Greengard Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 4159–4164. Published online 2007 February 27. doi: 10.1073/pnas.0611236104.PMCID: PMC1820725 Stimulus-specific competitive selection in macaque extrastriate visual area V4 Mazyar Fallah, Gene R. Stoner, and John H. Reynolds Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 4165–4169. Published online 2007 February 28. doi: 10.1073/pnas.0611722104.PMCID: PMC1820726 Ischemic insults promote epigenetic reprogramming of μ opioid receptor expression in hippocampal neurons Luigi Formisano, Kyung-Min Noh, Takahiro Miyawaki, Toshihiro Mashiko, Michael V. L. Bennett, and R. Suzanne Zukin Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 4170–4175. Published online 2007 February 28. doi: 10.1073/pnas.0611704104.PMCID: PMC1820727 PSD-95 is required for activity-driven synapse stabilization Ingrid Ehrlich, Matthew Klein, Simon Rumpel, and Roberto Malinow Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 4176–4181. Published online 2007 February 27. doi: 10.1073/pnas.0609307104.PMCID: PMC1820728 Ablation of D1 dopamine receptor-expressing cells generates mice with seizures, dystonia, hyperactivity, and impaired oral behavior Ilse Gantois, Ke Fang, Luning Jiang, Daniela Babovic, Andrew J. Lawrence, Vincenzo Ferreri, Yaroslav Teper, Bianca Jupp, Jenna Ziebell, Cristina M. Morganti-Kossmann, Terence J. O'Brien, Rachel Nally, Günter Schütz, John Waddington, Gary F. Egan, and John Drago Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 4182–4187. Published online 2007 February 28. doi: 10.1073/pnas.0611625104.PMCID: PMC1820729 A coherent neurobiological framework for functional neuroimaging provided by a model integrating compartmentalized energy metabolism Agnès Aubert, Luc Pellerin, Pierre J. Magistretti, and Robert Costalat Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 4188–4193. Published online 2007 February 28. doi: 10.1073/pnas.0605864104.PMCID: PMC1820730 Neuronal growth and survival mediated by eIF5A, a polyamine-modified translation initiation factor Yunfei Huang, Daniel S. Higginson, Lynda Hester, Myung Hee Park, and Solomon H. Snyder Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 4194–4199. Published online 2007 February 28. doi: 10.1073/pnas.0611609104.PMCID: PMC1820731 Physiology The proton pumping pathway of bovine heart cytochrome c oxidase Kunitoshi Shimokata, Yukie Katayama, Haruka Murayama, Makoto Suematsu, Tomitake Tsukihara, Kazumasa Muramoto, Hiroshi Aoyama, Shinya Yoshikawa, and Hideo Shimada Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 4200–4205. Published online 2007 February 28. doi: 10.1073/pnas.0611627104.PMCID: PMC1820732 Urocortin 3 regulates glucose-stimulated insulin secretion and energy homeostasis Chien Li, Peilin Chen, Joan Vaughan, Kuo-Fen Lee, and Wylie Vale Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 4206–4211. Published online 2007 February 27. doi: 10.1073/pnas.0611641104.PMCID: PMC1820733 Two forms of single-vesicle astrocyte exocytosis imaged with total internal reflection fluorescence microscopy David N. Bowser and Baljit S. Khakh Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 4212–4217. Published online 2007 February 26. doi: 10.1073/pnas.0607625104.PMCID: PMC1820734 Plant Biology From the Cover: Folate biofortification of tomato fruit Rocío I. Díaz de la Garza, Jesse F. Gregory, III, and Andrew D. Hanson Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 4218–4222. Published online 2007 March 5. doi: 10.1073/pnas.0700409104.PMCID: PMC1810332 Population Biology Using DNA to track the origin of the largest ivory seizure since the 1989 trade ban Samuel K. Wasser, Celia Mailand, Rebecca Booth, Benezeth Mutayoba, Emily Kisamo, Bill Clark, and Matthew Stephens Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 4228–4233. Published online 2007 February 26. doi: 10.1073/pnas.0609714104.PMCID: PMC1805457 Psychology Functional and morphometric brain dissociation between dyslexia and reading ability Fumiko Hoeft, Ann Meyler, Arvel Hernandez, Connie Juel, Heather Taylor-Hill, Jennifer L. Martindale, Glenn McMillon, Galena Kolchugina, Jessica M. Black, Afrooz Faizi, Gayle K. Deutsch, Wai Ting Siok, Allan L. Reiss, Susan Whitfield-Gabrieli, and John D. E. Gabrieli Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 4234–4239. Published online 2007 February 23. doi: 10.1073/pnas.0609399104.PMCID: PMC1820738 Cell Biology Correction for Amthor et al., Lack of myostatin results in excessive muscle growth but impaired force generation Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 4240. Published online 2007 February 23. doi: 10.1073/pnas.0701154104.PMCID: PMC1820739 Corrects: Helge Amthor, et al. Lack of myostatin results in excessive muscle growth but impaired force generation. Proc Natl Acad Sci U S A. 2007 February 6; 104(6): 1835–1840. Medical Sciences Correction for Palomero et al., NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth Proc Natl Acad Sci U S A. 2007 March 6; 104(10): 4240. Published online 2007 February 23. doi: 10.1073/pnas.0700840104.PMCID: PMC1820740 Corrects: Teresa Palomero, et al. NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth. Proc Natl Acad Sci U S A. 2006 November 28; 103(48): 18261–18266. |