| | This journal provides immediate access to some articles. Commentaries Treasures in the attic: Rolling circle transposons discovered in eukaryotic genomes Cédric Feschotte and Susan R. Wessler PMCID: PMC55346 Progress in plant metabolic engineering Pierre Broun and Chris Somerville PMCID: PMC55347 Mimicry: An interface between psychology and evolution James Mallet PMCID: PMC55348 Aβ immunization: Moving Aβ peptide from brain to blood Virginia M.-Y. Lee PMCID: PMC55349 Progress in cancer vaccines by enhanced self-presentation Stanley R. Riddell PMCID: PMC55350 Functional expression of a Drosophila odor receptor John R. Carlson PMCID: PMC55351 Physical Sciences Applied Physical Sciences Physical basis of two-tone interference in hearing Frank Jülicher, Daniel Andor, and Thomas Duke PMCID: PMC55376 Chemistry Detergent-phospholipid mixed micelles with a crystalline phospholipid core Sérgio S. Funari, Brigitte Nuscher, Gert Rapp, and Klaus Beyer PMCID: PMC55352 Carbohydrate self-recognition mediates marine sponge cellular adhesion Simon R. Haseley, Henricus J. Vermeer, Johannis P. Kamerling, and Johannes F. G. Vliegenthart PMCID: PMC55436 Engineering Image metrics in the statistical analysis of DNA microarray data Carl S. Brown, Paul C. Goodwin, and Peter K. Sorger PMCID: PMC55353 From the Cover:
Nanoparticle halos: A new colloid stabilization mechanism Valeria Tohver, James E. Smay, Alan Braem, Paul V. Braun, and Jennifer A. Lewis PMCID: PMC55354 DNA microarray reveals changes in gene expression of shear stressed human umbilical vein endothelial cells Susan M. McCormick, Suzanne G. Eskin, Larry V. McIntire, Christina L. Teng, Chiung-Mei Lu, Christopher G. Russell, and Krishnan K. Chittur PMCID: PMC55355 Statistics Bootstrapping cluster analysis: Assessing the reliability of conclusions from microarray experiments M. Kathleen Kerr and Gary A. Churchill PMCID: PMC55356 Biological Sciences Applied Biological Sciences From the Cover:
Trace amines: Identification of a family of mammalian G protein-coupled receptors Beth Borowsky, Nika Adham, Kenneth A. Jones, Rita Raddatz, Roman Artymyshyn, Kristine L. Ogozalek, Margaret M. Durkin, Parul P. Lakhlani, James A. Bonini, Sudam Pathirana, Noel Boyle, Xiaosui Pu, Evguenia Kouranova, Harvey Lichtblau, F. Yulina Ochoa, Theresa A. Branchek, and Christophe Gerald PMCID: PMC55357 Biochemistry INAUGURAL ARTICLE by a Recently Elected Academy Member: Restructuring of an RNA polymerase holoenzyme elongation complex by lambdoid phage Q proteins Michael T. Marr, Saul A. Datwyler, Claude F. Meares, and Jeffrey W. Roberts PMCID: PMC55358 Structural insights into the catalytic mechanism of a family 18 exo-chitinase D. M. F. van Aalten, D. Komander, B. Synstad, S. Gåseidnes, M. G. Peter, and V. G. H. Eijsink PMCID: PMC55359 A polymorphic dinucleotide repeat in the rat nucleolin gene forms Z-DNA and inhibits promoter activity Stefan Rothenburg, Friedrich Koch-Nolte, Alexander Rich, and Friedrich Haag PMCID: PMC55360 PAS kinase: An evolutionarily conserved PAS domain-regulated serine/threonine kinase Jared Rutter, Carolyn H. Michnoff, Shannon M. Harper, Kevin H. Gardner, and Steven L. McKnight PMCID: PMC55361 The mechanism of tryptophan induction of tryptophanase operon expression: Tryptophan inhibits release factor-mediated cleavage of TnaC-peptidyl-tRNAPro Feng Gong, Koichi Ito, Yoshikazu Nakamura, and Charles Yanofsky PMCID: PMC55362 Analysis of mutations at residues A2451 and G2447 of 23S rRNA in the peptidyltransferase active site of the 50S ribosomal subunit Jill Thompson, Daniel F. Kim, Michael O'Connor, Kate R. Lieberman, Mark A. Bayfield, Steven T. Gregory, Rachel Green, Harry F. Noller, and Albert E. Dahlberg PMCID: PMC55363 Molecular determinants for CC-chemokine recognition by a poxvirus CC-chemokine inhibitor Bruce T. Seet, Rajkumari Singh, Chad Paavola, Elaine K. Lau, Tracy M. Handel, and Grant McFadden PMCID: PMC55364 Rac1 mediates STAT3 activation by autocrine IL-6 Tatjana R. Faruqi, Dolores Gomez, Xosé R. Bustelo, Dafna Bar-Sagi, and Nancy C. Reich PMCID: PMC55365 Function of the bacterial TATAAT −10 element as single-stranded DNA during RNA polymerase isomerization Mike S. Fenton and Jay D. Gralla PMCID: PMC55366 Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members Tomohiko Mizutani, Yoshihito Taniguchi, Tomokazu Aoki, Nobuo Hashimoto, and Tasuku Honjo PMCID: PMC55367 Substrate conformational transitions in the active site of chorismate mutase: Their role in the catalytic mechanism Hong Guo, Qiang Cui, William N. Lipscomb, and Martin Karplus PMCID: PMC55368 The subunit structure and catalytic mechanism of the Bacillus subtilis DNA repair enzyme spore photoproduct lyase Roberto Rebeil and Wayne L. Nicholson PMCID: PMC55369 Insulin alters heterogeneous nuclear ribonucleoprotein K protein binding to DNA and RNA J. Ostrowski, Y. Kawata, D. S. Schullery, O. N. Denisenko, Y. Higaki, C. K. Abrass, and K. Bomsztyk PMCID: PMC55370 An essential role of the JAK-STAT pathway in ischemic preconditioning Yu-Ting Xuan, Yiru Guo, Hui Han, Yanqing Zhu, and Roberto Bolli PMCID: PMC55371 Biophysics Detergent-phospholipid mixed micelles with a crystalline phospholipid core Sérgio S. Funari, Brigitte Nuscher, Gert Rapp, and Klaus Beyer PMCID: PMC55352 The Cα—H ![[center dot]](corehtml/pmc/pmcents/middot.gif) O hydrogen bond: A determinant of stability and specificity in transmembrane helix interactions Alessandro Senes, Iban Ubarretxena-Belandia, and Donald M. Engelman PMCID: PMC55372 Folding and signaling share the same pathway in a photoreceptor Byoung-Chul Lee, Adarsh Pandit, Paula A. Croonquist, and Wouter D. Hoff PMCID: PMC55373 Effects of DNA sequence and structure on binding of RecA to single-stranded DNA R. Bar-Ziv and A. Libchaber PMCID: PMC55374 A minimalist model protein with multiple folding funnels C. Rebecca Locker and Rigoberto Hernandez PMCID: PMC55375 Physical basis of two-tone interference in hearing Frank Jülicher, Daniel Andor, and Thomas Duke PMCID: PMC55376 Cell Biology ATP transduces signals from ASGM1, a glycolipid that functions as a bacterial receptor Nancy McNamara, Amy Khong, David McKemy, Mike Caterina, Jose Boyer, David Julius, and Carol Basbaum PMCID: PMC55377 ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation Paul Nghiem, Peter K. Park, Yong-son Kim, Cyrus Vaziri, and Stuart L. Schreiber PMCID: PMC55378 The sorbin homology domain: A motif for the targeting of proteins to lipid rafts Akiko Kimura, Christian A. Baumann, Shian-Huey Chiang, and Alan R. Saltiel PMCID: PMC55379 A mutant plasma membrane ATPase, Pma1-10, is defective in stability at the yeast cell surface Xiaohua Gong and Amy Chang PMCID: PMC55380 α-Synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins Ronit Sharon, Matthew S. Goldberg, Ifat Bar-Josef, Rebecca A. Betensky, Jie Shen, and Dennis J. Selkoe PMCID: PMC55381 A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver Hiromi Yamashita, Makoto Takenoshita, Masaharu Sakurai, Richard K. Bruick, William J. Henzel, Wendy Shillinglaw, David Arnot, and Kosaku Uyeda PMCID: PMC55382 Myosin I mutants with only 1% of wild-type actin-activated MgATPase activity retain essential in vivo function(s) Xiong Liu, Nir Osherov, Roxanne Yamashita, Hanna Brzeska, Edward D. Korn, and Gregory S. May PMCID: PMC55383 Polo-like kinase is required for the fragmentation of pericentriolar Golgi stacks during mitosis Christine Sütterlin, Chin-Yo Lin, Yang Feng, Douglas K. Ferris, Raymond L. Erikson, and Vivek Malhotra PMCID: PMC55384 Developmental Biology Presence of mitochondria-type ribosomes outside mitochondria in germ plasm of Drosophila embryos Reiko Amikura, Maki Kashikawa, Akira Nakamura, and Satoru Kobayashi PMCID: PMC55385 Conditional epidermal expression of TGFβ1 blocks neonatal lethality but causes a reversible hyperplasia and alopecia Xin Liu, Valarie Alexander, Kinnimulki Vijayachandra, Ervind Bhogte, Ilysa Diamond, and Adam Glick PMCID: PMC55386 Specific repression of β-globin promoter activity by nuclear ferritin Robert H. Broyles, Visar Belegu, Christina R. DeWitt, Sandeep N. Shah, Charles A. Stewart, Quentin N. Pye, and Robert A. Floyd PMCID: PMC55387 Evolution How cuckoldry can decrease the opportunity for sexual selection: Data and theory from a genetic parentage analysis of the sand goby, Pomatoschistus minutus Adam G. Jones, DeEtte Walker, Charlotta Kvarnemo, Kai Lindström, and John C. Avise PMCID: PMC55388 Strength and tempo of directional selection in the wild H. E. Hoekstra, J. M. Hoekstra, D. Berrigan, S. N. Vignieri, A. Hoang, C. E. Hill, P. Beerli, and J. G. Kingsolver PMCID: PMC55389 Patterns of DNA sequence polymorphism along chromosome 1 of maize (Zea mays ssp. mays L.) Maud I. Tenaillon, Mark C. Sawkins, Anthony D. Long, Rebecca L. Gaut, John F. Doebley, and Brandon S. Gaut PMCID: PMC55390 Colonization of America by Drosophila subobscura: Heterotic effect of chromosomal arrangements revealed by the persistence of lethal genes F. Mestres, J. Balanyà, C. Arenas, E. Solé, and L. Serra PMCID: PMC55391 Reproductive aging and mating: The ticking of the biological clock in female cockroaches Patricia J. Moore and Allen J. Moore PMCID: PMC55392 Eavesdropping and animal conflict Rufus A. Johnstone PMCID: PMC55393 From the Cover:
Strong antiapostatic selection against novel rare aposematic prey Leena Lindström, Rauno V. Alatalo, Anne Lyytinen, and Johanna Mappes PMCID: PMC55394 Evolutionary self-organization of cell-free genetic coding Rudolf M. Füchslin and John S. McCaskill PMCID: PMC55395 Genetics Bootstrapping cluster analysis: Assessing the reliability of conclusions from microarray experiments M. Kathleen Kerr and Gary A. Churchill PMCID: PMC55356 Efficient chromosomal transposition of a Tc1/mariner- like transposon Sleeping Beauty in mice Kyoji Horie, Asato Kuroiwa, Masahito Ikawa, Masaru Okabe, Gen Kondoh, Yoichi Matsuda, and Junji Takeda PMCID: PMC55396 Comparative expressed sequence hybridization to chromosomes for tumor classification and identification of genomic regions of differential gene expression Yong-Jie Lu, Daniel Williamson, Jeremy Clark, Rubin Wang, Nicki Tiffin, Lorraine Skelton, Tony Gordon, Richard Williams, Barry Allan, Ann Jackman, Colin Cooper, Kathy Pritchard-Jones, and Janet Shipley PMCID: PMC55397 Growth hormone interacts with the Marek's disease virus SORF2 protein and is associated with disease resistance in chicken Hsiao-Ching Liu, Hsing-Jien Kung, Janet E. Fulton, Robin W. Morgan, and Hans H. Cheng PMCID: PMC55398 Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells Ate Loonstra, Marc Vooijs, H. Berna Beverloo, Bushra Al Allak, Ellen van Drunen, Roland Kanaar, Anton Berns, and Jos Jonkers PMCID: PMC55399 PNA interference mapping demonstrates functional domains in the noncoding RNA Xist Anton Beletskii, Young-Kwon Hong, John Pehrson, Michael Egholm, and William M. Strauss PMCID: PMC55400 Circadian rhythms of female mating activity governed by clock genes in Drosophila Takaomi Sakai and Norio Ishida PMCID: PMC55401 Immunology Immunosuppression by CD4+ regulatory T cells induced by chronic retroviral infection Michihiro Iwashiro, Ronald J. Messer, Karin E. Peterson, Ingunn M. Stromnes, Tomoharu Sugie, and Kim J. Hasenkrug PMCID: PMC55402 Energetic asymmetry among hydrogen bonds in MHC class II peptide complexes Benjamin J. McFarland, John F. Katz, Craig Beeson, and Andrea J. Sant PMCID: PMC55403 Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition Stefan Bauer, Carsten J. Kirschning, Hans Häcker, Vanessa Redecke, Susanne Hausmann, Shizuo Akira, Hermann Wagner, and Grayson B. Lipford PMCID: PMC55404 Paradoxical intrathymic positive selection in mice with only a covalently presented agonist peptide Christophe Viret, Xin He, and Charles A. Janeway, Jr. PMCID: PMC55405 “Electronic nose” detects major histocompatibility complex-dependent prerenal and postrenal odor components Stefanie Montag, Michael Frank, Heiko Ulmer, Dorothee Wernet, Wolfgang Göpel, and Hans-Georg Rammensee PMCID: PMC55406 Medical Sciences A role of PDGFRα in basal cell carcinoma proliferation Jingwu Xie, Michelle Aszterbaum, Xiaoli Zhang, Jeannette M. Bonifas, Christopher Zachary, Ervin Epstein, and Frank McCormick PMCID: PMC55407 Elevated arginase I expression in rat aortic smooth muscle cells
increases cell proliferation Liu Hua Wei, Guoyao Wu, Sidney M. Morris, Jr., and Louis J. Ignarro PMCID: PMC55408 Angiogenic role for glycodelin in tumorigenesis Mingqing Song, Sreemathy Ramaswamy, Sumathi Ramachandran, Lisa C. Flowers, Ira R. Horowitz, John A. Rock, and Sampath Parthasarathy PMCID: PMC55409 From the Cover:
An HIV-1 transgenic rat that develops HIV-related pathology and immunologic dysfunction W. Reid, M. Sadowska, F. Denaro, S. Rao, J. Foulke, Jr., N. Hayes, O. Jones, D. Doodnauth, H. Davis, A. Sill, P. O'Driscoll, D. Huso, T. Fouts, G. Lewis, M. Hill, R. Kamin-Lewis, C. Wei, P. Ray, R. C. Gallo, M. Reitz, and J. Bryant PMCID: PMC55410 IL-7 differentially regulates cell cycle progression and HIV-1-based vector infection in neonatal and adult CD4+ T cells Valérie Dardalhon, Sara Jaleco, Sandrina Kinet, Bjorn Herpers, Marcos Steinberg, Christophe Ferrand, Delphine Froger, Christelle Leveau, Pierre Tiberghien, Pierre Charneau, Nelly Noraz, and Naomi Taylor PMCID: PMC55411 Perforin-low memory CD8+ cells are the predominant T cells in normal humans that synthesize the β-chemokine macrophage inflammatory protein-1β Roberta Kamin-Lewis, Sayed F. Abdelwahab, Christine Trang, Amanda Baker, Anthony L. DeVico, Robert C. Gallo, and George K. Lewis PMCID: PMC55412 Neuroinvasion by a Creutzfeldt–Jakob disease agent in the absence of B cells and follicular dendritic cells Mark J. Shlomchik, Klaus Radebold, Nicole Duclos, and Laura Manuelidis PMCID: PMC55413 Scrapie prion protein accumulation by scrapie-infected neuroblastoma cells abrogated by exposure to a prion protein antibody Masato Enari, Eckhard Flechsig, and Charles Weissmann PMCID: PMC55414 Imaging transcriptional regulation of p53-dependent genes with positron emission tomography in vivo Michael Doubrovin, Vladimir Ponomarev, Tatiana Beresten, Julius Balatoni, William Bornmann, Ronald Finn, John Humm, Steven Larson, Michel Sadelain, Ronald Blasberg, and Juri Gelovani Tjuvajev PMCID: PMC55415 Regulation of myostatin activity and muscle growth Se-Jin Lee and Alexandra C. McPherron PMCID: PMC55416 Presenilin-dependent γ-secretase activity modulates thymocyte development Petra Doerfler, Mark S. Shearman, and Roger M. Perlmutter PMCID: PMC55417 M cell-targeted DNA vaccination Yunpeng Wu, Xinhai Wang, Keri L. Csencsits, Asmahan Haddad, Nancy Walters, and David W. Pascual PMCID: PMC55418 Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3 Andrew W. Roberts, Lorraine Robb, Steven Rakar, Lynne Hartley, Leonie Cluse, Nicos A. Nicola, Donald Metcalf, Douglas J. Hilton, and Warren S. Alexander PMCID: PMC55419 An inherited p53 mutation that contributes in a tissue-specific manner to pediatric adrenal cortical carcinoma Raul C. Ribeiro, Fabiano Sandrini, Bonald Figueiredo, Gerard P. Zambetti, Edson Michalkiewicz, Antony R. Lafferty, Luiz DeLacerda, Mark Rabin, Craig Cadwell, Gilberto Sampaio, Israil Cat, Constantine A. Stratakis, and Romolo Sandrini PMCID: PMC55420 Gene program for cardiac cell survival induced by transient ischemia in conscious pigs Christophe Depre, James E. Tomlinson, Raymond K. Kudej, Vinciane Gaussin, Erika Thompson, Song-Jung Kim, Dorothy E. Vatner, James N. Topper, and Stephen F. Vatner PMCID: PMC55421 Microbiology A genomic island in Pseudomonas aeruginosa carries the determinants of flagellin glycosylation Shiwani K. Arora, Mahalaxmi Bangera, Stephen Lory, and Reuben Ramphal PMCID: PMC55422 Holins kill without warning Angelika Gründling, Michael D. Manson, and Ry Young PMCID: PMC55423 Globin-coupled sensors: A class of heme-containing sensors in Archaea and Bacteria Shaobin Hou, Tracey Freitas, Randy W. Larsen, Mikhail Piatibratov, Victor Sivozhelezov, Amy Yamamoto, Ella A. Meleshkevitch, Mike Zimmer, George W. Ordal, and Maqsudul Alam PMCID: PMC55424 Assembling filamentous phage occlude pIV channels Denise K. Marciano, Marjorie Russel, and Sanford M. Simon PMCID: PMC55425 Structural rationale for the modulation of abscess formation by Staphylococcus aureus capsular polysaccharides Arthur O. Tzianabos, Julia Y. Wang, and Jean C. Lee PMCID: PMC55426 Neurobiology Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase Benjamin F. Cravatt, Kristin Demarest, Matthew P. Patricelli, Michael H. Bracey, Dan K. Giang, Billy R. Martin, and Aron H. Lichtman PMCID: PMC55427 From the Cover:
Functional expression and characterization of a Drosophila odorant receptor in a heterologous cell system Christian H. Wetzel, Hans-Jörg Behrendt, Günter Gisselmann, Klemens F. Störtkuhl, Bernd Hovemann, and Hanns Hatt PMCID: PMC55428 From the Cover:
Functional analysis of an olfactory receptor in Drosophila melanogaster Klemens F. Störtkuhl and Raffael Kettler PMCID: PMC55429 Firing rates of hippocampal neurons are preserved during subsequent sleep episodes and modified by novel awake experience Hajime Hirase, Xavier Leinekugel, András Czurkó, Jozsef Csicsvari, and György Buzsáki PMCID: PMC55430 Transient decrease in water diffusion observed in human occipital cortex during visual stimulation Anne Darquié, Jean-Baptiste Poline, Cyril Poupon, Hervé Saint-Jalmes, and Denis Le Bihan PMCID: PMC55431 Distinct mechanisms of cell cycle arrest control the decision between differentiation and senescence in human neuroblastoma cells Linda J. Wainwright, Anna Lasorella, and Antonio Iavarone PMCID: PMC55432 A hebbian form of long-term potentiation dependent on mGluR1a in hippocampal inhibitory interneurons Yaël Perez, France Morin, and Jean-Claude Lacaille PMCID: PMC55433 Pharmacology Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A1 receptor Björn Johansson, Linda Halldner, Thomas V. Dunwiddie, Susan A. Masino, Wolfgang Poelchen, Lydia Giménez-Llort, Rosa M. Escorihuela, Alberto Fernández-Teruel, Zsuzsanna Wiesenfeld-Hallin, Xiao-Jun Xu, Anna Hårdemark, Christer Betsholtz, Eric Herlenius, and Bertil B. Fredholm PMCID: PMC55434 Physiology Effects of forced diving on the spleen and hepatic sinus in northern elephant seal pups Sheila J. Thornton, Daniel M. Spielman, Norbert J. Pelc, Wally F. Block, Daniel E. Crocker, Daniel P. Costa, Burney J. LeBoeuf, and Peter W. Hochachka PMCID: PMC55435 Carbohydrate self-recognition mediates marine sponge cellular adhesion Simon R. Haseley, Henricus J. Vermeer, Johannis P. Kamerling, and Johannes F. G. Vliegenthart PMCID: PMC55436 Identification of a chloride-formate exchanger expressed on the brush border membrane of renal proximal tubule cells Felix Knauf, Chao-Ling Yang, R. Brent Thomson, Sue Ann Mentone, Gerhard Giebisch, and Peter S. Aronson PMCID: PMC55437 Expression cloning of two genes that together mediate organic solute and steroid transport in the liver of a marine vertebrate Wei Wang, David J. Seward, Liqiong Li, James L. Boyer, and Nazzareno Ballatori PMCID: PMC55438 Plant Biology Multiple transcription-factor genes are early targets of phytochrome A signaling James M. Tepperman, Tong Zhu, Hur-Song Chang, Xun Wang, and Peter H. Quail PMCID: PMC55439 Transpiration, a prerequisite for long-distance transport of minerals in plants? W. Tanner and H. Beevers PMCID: PMC55440 A fatty acid desaturase modulates the activation of defense signaling pathways in plants Pradeep Kachroo, John Shanklin, Jyoti Shah, Edward J. Whittle, and Daniel F. Klessig PMCID: PMC55441 The Y chromosome in the liverwort Marchantia polymorpha has accumulated unique repeat sequences harboring a male-specific gene Sachiko Okada, Takefumi Sone, Masaki Fujisawa, Shigeki Nakayama, Mizuki Takenaka, Kimitsune Ishizaki, Kaoru Kono, Yuu Shimizu-Ueda, Tsutomu Hanajiri, Katsuyuki T. Yamato, Hideya Fukuzawa, Axel Brennicke, and Kanji Ohyama PMCID: PMC55442 Population Biology Reproductive constraints and the evolution of life histories with indeterminate growth Eric L. Charnov, Thomas F. Turner, and Kirk O. Winemiller PMCID: PMC55443 |
