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Volume 98(15);  July 17, 2001
Colloquium Papers
INTRODUCTION - Links between recombination and replication: Vital roles of recombination
Charles Radding
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8172. doi: 10.1073/pnas.161004898.
PMCID: PMC37417
Historical overview: Searching for replication help in all of the rec places
Michael M. Cox
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8173–8180. doi: 10.1073/pnas.131004998.
PMCID: PMC37418
Rescue of arrested replication forks by homologous recombination
Bénédicte Michel, Maria-Jose Flores, Enrique Viguera, Gianfranco Grompone, Marie Seigneur, and Vladimir Bidnenko
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8181–8188. doi: 10.1073/pnas.111008798.
PMCID: PMC37419
Circles: The replication-recombination-chromosome segregation connection
François-Xavier Barre, Britta Søballe, Bénédicte Michel, Mira Aroyo, Malcolm Robertson, and David Sherratt
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8189–8195. doi: 10.1073/pnas.111008998.
PMCID: PMC37420
Participation of recombination proteins in rescue of arrested replication forks in UV-irradiated Escherichia coli need not involve recombination
Justin Courcelle and Philip C. Hanawalt
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8196–8202. doi: 10.1073/pnas.121008898.
PMCID: PMC37421
Effects of mutations involving cell division, recombination, and chromosome dimer resolution on a priA2::kan mutant
Jesse D. McCool and Steven J. Sandler
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8203–8210. doi: 10.1073/pnas.121007698.
PMCID: PMC37422
RecA protein promotes the regression of stalled replication forks in vitro
Mara E. Robu, Ross B. Inman, and Michael M. Cox
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8211–8218. doi: 10.1073/pnas.131022698.
PMCID: PMC37423
Topological challenges to DNA replication: Conformations at the fork
Lisa Postow, Nancy J. Crisona, Brian J. Peter, Christine D. Hardy, and Nicholas R. Cozzarelli
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8219–8226. doi: 10.1073/pnas.111006998.
PMCID: PMC37424
Rescue of stalled replication forks by RecG: Simultaneous translocation on the leading and lagging strand templates supports an active DNA unwinding model of fork reversal and Holliday junction formation
Peter McGlynn and Robert G. Lloyd
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8227–8234. doi: 10.1073/pnas.111008698.
PMCID: PMC37425
Formation of Holliday junctions by regression of nascent DNA in intermediates containing stalled replication forks: RecG stimulates regression even when the DNA is negatively supercoiled
Peter McGlynn, Robert G. Lloyd, and Kenneth J. Marians
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8235–8240. doi: 10.1073/pnas.121007798.
PMCID: PMC37426
Single-strand interruptions in replicating chromosomes cause double-strand breaks
Andrei Kuzminov
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8241–8246. doi: 10.1073/pnas.131009198.
PMCID: PMC37427
Handoff from recombinase to replisome: Insights from transposition
Hiroshi Nakai, Victoria Doseeva, and Jessica M. Jones
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8247–8254. doi: 10.1073/pnas.111007898.
PMCID: PMC37428
Break-induced replication: A review and an example in budding yeast
Eliyahu Kraus, Wai-Ying Leung, and James E. Haber
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8255–8262. doi: 10.1073/pnas.151008198.
PMCID: PMC37429
Links between replication and recombination in Saccharomyces cerevisiae: A hypersensitive requirement for homologous recombination in the absence of Rad27 activity
Hélène Debrauwère, Sophie Loeillet, Waka Lin, Judith Lopes, and Alain Nicolas
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8263–8269. doi: 10.1073/pnas.121075598.
PMCID: PMC37430
Evidence that replication fork components catalyze establishment of cohesion between sister chromatids
Dena R. Carson and Michael F. Christman
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8270–8275. doi: 10.1073/pnas.131022798.
PMCID: PMC37431
Rad52 forms DNA repair and recombination centers during S phase
Michael Lisby, Rodney Rothstein, and Uffe H. Mortensen
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8276–8282. doi: 10.1073/pnas.121006298.
PMCID: PMC37432
A yeast gene, MGS1, encoding a DNA-dependent AAA+ ATPase is required to maintain genome stability
Takashi Hishida, Hiroshi Iwasaki, Takayuki Ohno, Takashi Morishita, and Hideo Shinagawa
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8283–8289. doi: 10.1073/pnas.121009098.
PMCID: PMC37433
The tight linkage between DNA replication and double-strand break repair in bacteriophage T4
James W. George, Bradley A. Stohr, Daniel J. Tomso, and Kenneth N. Kreuzer
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8290–8297. doi: 10.1073/pnas.131007598.
PMCID: PMC37434
Mediator proteins orchestrate enzyme-ssDNA assembly during T4 recombination-dependent DNA replication and repair
Jill S. Bleuit, Hang Xu, Yujie Ma, Tongsheng Wang, Jie Liu, and Scott W. Morrical
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8298–8305. doi: 10.1073/pnas.131007498.
PMCID: PMC37435
Two recombination-dependent DNA replication pathways of bacteriophage T4, and their roles in mutagenesis and horizontal gene transfer
Gisela Mosig, John Gewin, Andreas Luder, Nancy Colowick, and Daniel Vo
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8306–8311. doi: 10.1073/pnas.131007398.
PMCID: PMC37436
Bacteriophage T4 gene 41 helicase and gene 59 helicase-loading protein: A versatile couple with roles in replication and recombination
Charles E. Jones, Timothy C. Mueser, Kathleen C. Dudas, Kenneth N. Kreuzer, and Nancy G. Nossal
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8312–8318. doi: 10.1073/pnas.121009398.
PMCID: PMC37437
Instability of repetitive DNA sequences: The role of replication in multiple mechanisms
Malgorzata Bzymek and Susan T. Lovett
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8319–8325. doi: 10.1073/pnas.111008398.
PMCID: PMC37438
Repeat expansion by homologous recombination in the mouse germ line at palindromic sequences
Zhi-Hong Zhou, Ercan Akgün, and Maria Jasin
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8326–8333. doi: 10.1073/pnas.151008498.
PMCID: PMC37439
Stationary-phase mutation in the bacterial chromosome: Recombination protein and DNA polymerase IV dependence
Harold J. Bull, Mary-Jane Lombardo, and Susan M. Rosenberg
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8334–8341. doi: 10.1073/pnas.151009798.
PMCID: PMC37440
Managing DNA polymerases: Coordinating DNA replication, DNA repair, and DNA recombination
Mark D. Sutton and Graham C. Walker
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8342–8349. doi: 10.1073/pnas.111036998.
PMCID: PMC37441
Roles of DNA polymerases V and II in SOS-induced error-prone and error-free repair in Escherichia coli
Phuong Pham, Savithri Rangarajan, Roger Woodgate, and Myron F. Goodman
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8350–8354. doi: 10.1073/pnas.111007198.
PMCID: PMC37442
Accuracy of lesion bypass by yeast and human DNA polymerase η
M. Todd Washington, Robert E. Johnson, Louise Prakash, and Satya Prakash
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8355–8360. doi: 10.1073/pnas.121007298.
PMCID: PMC37443
ATP bound to the origin recognition complex is important for preRC formation
Richard D. Klemm and Stephen P. Bell
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8361–8367. doi: 10.1073/pnas.131006898.
PMCID: PMC37444
Creating a dynamic picture of the sliding clamp during T4 DNA polymerase holoenzyme assembly by using fluorescence resonance energy transfer
Michael A. Trakselis, Stephen C. Alley, Ernesto Abel-Santos, and Stephen J. Benkovic
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8368–8375. doi: 10.1073/pnas.111006698.
PMCID: PMC37445
Interaction of the β sliding clamp with MutS, ligase, and DNA polymerase I
Francisco J. López de Saro and Mike O'Donnell
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8376–8380. doi: 10.1073/pnas.121009498.
PMCID: PMC37446
Defining the roles of individual residues in the single-stranded DNA binding site of PcrA helicase
Mark S. Dillingham, Panos Soultanas, Paul Wiley, Martin R. Webb, and Dale B. Wigley
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8381–8387. doi: 10.1073/pnas.131009598.
PMCID: PMC37447
Homologous DNA recombination in vertebrate cells
Eiichiro Sonoda, Minoru Takata, Yukiko M. Yamashita, Ciaran Morrison, and Shunichi Takeda
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8388–8394. doi: 10.1073/pnas.111006398.
PMCID: PMC37448
Meiotic recombination and chromosome segregation in Schizosaccharomyces pombe
Luther Davis and Gerald R. Smith
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8395–8402. doi: 10.1073/pnas.121005598.
PMCID: PMC37449
Manipulating the mammalian genome by homologous recombination
Karen M. Vasquez, Kathleen Marburger, Zsofia Intody, and John H. Wilson
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8403–8410. doi: 10.1073/pnas.111009698.
PMCID: PMC37450
Assembly of RecA-like recombinases: Distinct roles for mediator proteins in mitosis and meiosis
Stephen L. Gasior, Heidi Olivares, Uy Ear, Danielle M. Hari, Ralph Weichselbaum, and Douglas K. Bishop
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8411–8418. doi: 10.1073/pnas.121046198.
PMCID: PMC37451
Domain structure and dynamics in the helical filaments formed by RecA and Rad51 on DNA
Xiong Yu, Steven A. Jacobs, Stephen C. West, Tomoko Ogawa, and Edward H. Egelman
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8419–8424. doi: 10.1073/pnas.111005398.
PMCID: PMC37452
Homologous genetic recombination as an intrinsic dynamic property of a DNA structure induced by RecA/Rad51-family proteins: A possible advantage of DNA over RNA as genomic material
Takehiko Shibata, Taro Nishinaka, Tsutomu Mikawa, Hideki Aihara, Hitoshi Kurumizaka, Shigeyuki Yokoyama, and Yutaka Ito
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8425–8432. doi: 10.1073/pnas.111005198.
PMCID: PMC37453
The synaptic activity of HsDmc1, a human recombination protein specific to meiosis
R. C. Gupta, E. Golub, B. Bi, and C. M. Radding
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8433–8439. doi: 10.1073/pnas.121005298.
PMCID: PMC37454
Complex formation by the human RAD51C and XRCC3 recombination repair proteins
Jean-Yves Masson, Alicja Z. Stasiak, Andrzej Stasiak, Fiona E. Benson, and Stephen C. West
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8440–8446. doi: 10.1073/pnas.111005698.
PMCID: PMC37455
Rad54 protein stimulates the postsynaptic phase of Rad51 protein-mediated DNA strand exchange
Jachen Armon Solinger and Wolf-Dietrich Heyer
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8447–8453. doi: 10.1073/pnas.121009898.
PMCID: PMC37456
The architecture of the human Rad54–DNA complex provides evidence for protein translocation along DNA
Dejan Ristic, Claire Wyman, Coen Paulusma, and Roland Kanaar
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8454–8460. doi: 10.1073/pnas.151056798.
PMCID: PMC37457
DNA replication meets genetic exchange: Chromosomal damage and its repair by homologous recombination
Andrei Kuzminov
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8461–8468. doi: 10.1073/pnas.151260698.
PMCID: PMC37458
Editorial
Unfettered access to published results
Nicholas R. Cozzarelli
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8159. Published online 2001 July 10. doi: 10.1073/pnas.171309098.
PMCID: PMC37411
Commentaries
Hepcidin: A putative iron-regulatory hormone relevant to hereditary hemochromatosis and the anemia of chronic disease
Robert E. Fleming and William S. Sly
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8160–8162. doi: 10.1073/pnas.161296298.
PMCID: PMC37412
Gene galaxies in the maize genome
Virginia Walbot and Dmitri A. Petrov
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8163–8164. doi: 10.1073/pnas.161278798.
PMCID: PMC37413
Structural basis for bending tropomyosin around actin in muscle thin filaments
Murray Stewart
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8165–8166. doi: 10.1073/pnas.151265198.
PMCID: PMC37414
Dehydroepiandrosterone sulfate and longevity: New clues for an old friend
Samuel S. C. Yen
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8167–8169. doi: 10.1073/pnas.161278698.
PMCID: PMC37415
Probing the mechanism of enzymatic phosphoryl transfer with a chemical trick
Paul R. Thompson and Philip A. Cole
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8170–8171. doi: 10.1073/pnas.161273998.
PMCID: PMC37416
Physical Sciences
Chemistry
Single-molecule spectroscopy of the β2 adrenergic receptor: Observation of conformational substates in a membrane protein
Gadi Peleg, Pejman Ghanouni, Brian K. Kobilka, and Richard N. Zare
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8469–8474. Published online 2001 July 3. doi: 10.1073/pnas.151239698.
PMCID: PMC37459
The relaxation dynamics of the excited electronic states of retinal in bacteriorhodopsin by two-pump-probe femtosecond studies
S. L. Logunov, V. V. Volkov, M. Braun, and M. A. El-Sayed
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8475–8479. Published online 2001 July 10. doi: 10.1073/pnas.141220198.
PMCID: PMC37460
Antibodies with infinite affinity
Albert J. Chmura, Molly S. Orton, and Claude F. Meares
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8480–8484. Published online 2001 July 10. doi: 10.1073/pnas.151260298.
PMCID: PMC37461
Physics
Tuning DNA “strings”: Modulating the rate of DNA replication with mechanical tension
Anita Goel, Maxim D. Frank-Kamenetskii, Tom Ellenberger, and Dudley Herschbach
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8485–8489. Published online 2001 July 10. doi: 10.1073/pnas.151261198.
PMCID: PMC37462
Force and kinetic barriers to unzipping of the DNA double helix
Simona Cocco, Rémi Monasson, and John F. Marko
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8608–8613. Published online 2001 July 10. doi: 10.1073/pnas.151257598.
PMCID: PMC37483
Biological Sciences
Biochemistry
DNA bending by an adenine–thymine tract and its role in gene regulation
Jenny Hizver, Haim Rozenberg, Felix Frolow, Dov Rabinovich, and Zippora Shakked
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8490–8495. Published online 2001 July 3. doi: 10.1073/pnas.151247298.
PMCID: PMC37463
Deciphering the design of the tropomyosin molecule
Jerry H. Brown, Kyoung-Hee Kim, Gyo Jun, Norma J. Greenfield, Roberto Dominguez, Niels Volkmann, Sarah E. Hitchcock-DeGregori, and Carolyn Cohen
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8496–8501. Published online 2001 July 3. doi: 10.1073/pnas.131219198.
PMCID: PMC37464
The trimer-of-hairpins motif in membrane fusion: Visna virus
Vladimir N. Malashkevich, Mona Singh, and Peter S. Kim
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8502–8506. Published online 2001 July 10. doi: 10.1073/pnas.151254798.
PMCID: PMC37465
Solution structure of the 2-amino-1- methyl-6-phenylimidazo[4,5-b]pyridine C8-deoxyguanosine adduct in duplex DNA
Karen Brown, Brian E. Hingerty, Elizabeth A. Guenther, V. V. Krishnan, Suse Broyde, Kenneth W. Turteltaub, and Monique Cosman
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8507–8512. Published online 2001 July 3. doi: 10.1073/pnas.151251898.
PMCID: PMC37466
Biosynthesis of the thiazole moiety of thiamin in Escherichia coli: Identification of an acyldisulfide-linked protein–protein conjugate that is functionally analogous to the ubiquitin/E1 complex
Jun Xi, Ying Ge, Cynthia Kinsland, Fred W. McLafferty, and Tadhg P. Begley
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8513–8518. Published online 2001 July 3. doi: 10.1073/pnas.141226698.
PMCID: PMC37467
Energy-driven subunit rotation at the interface between subunit a and the c oligomer in the FO sector of Escherichia coli ATP synthase
Marcus L. Hutcheon, Thomas M. Duncan, Helen Ngai, and Richard L. Cross
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8519–8524. Published online 2001 July 3. doi: 10.1073/pnas.151236798.
PMCID: PMC37468
From the Cover:
BeFequation M1 acts as a phosphate analog in proteins phosphorylated on aspartate: Structure of a BeFequation M2 complex with phosphoserine phosphatase
Ho Cho, Weiru Wang, Rosalind Kim, Hisao Yokota, Steven Damo, Sung-Hou Kim, David Wemmer, Sydney Kustu, and Dalai Yan
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8525–8530. Published online 2001 July 3. doi: 10.1073/pnas.131213698.
PMCID: PMC37469
Location and properties of metal-binding sites on the human prion protein
Graham S. Jackson, Ian Murray, Laszlo L. P. Hosszu, Nicholas Gibbs, Jonathan P. Waltho, Anthony R. Clarke, and John Collinge
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8531–8535. Published online 2001 July 3. doi: 10.1073/pnas.151038498.
PMCID: PMC37470
A mutant cholera toxin B subunit that binds GM1- ganglioside but lacks immunomodulatory or toxic activity
A. T. Aman, S. Fraser, E. A. Merritt, C. Rodigherio, M. Kenny, M. Ahn, W. G. J. Hol, N. A. Williams, W. I. Lencer, and T. R. Hirst
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8536–8541. Published online 2001 July 10. doi: 10.1073/pnas.161273098.
PMCID: PMC37471
The endopolyphosphatase gene: Essential in Saccharomyces cerevisiae
Anand Sethuraman, Narayana N. Rao, and Arthur Kornberg
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8542–8547. Published online 2001 July 10. doi: 10.1073/pnas.151269398.
PMCID: PMC37472
Molecular cloning and sequence analysis of the complestatin biosynthetic gene cluster
Hsien-Tai Chiu, Brian K. Hubbard, Aseema N. Shah, Jonathan Eide, Ross A. Fredenburg, Christopher T. Walsh, and Chaitan Khosla
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8548–8553. Published online 2001 July 10. doi: 10.1073/pnas.151246498.
PMCID: PMC37473
Protacs: Chimeric molecules that target proteins to the Skp1–Cullin–F box complex for ubiquitination and degradation
Kathleen M. Sakamoto, Kyung B. Kim, Akiko Kumagai, Frank Mercurio, Craig M. Crews, and Raymond J. Deshaies
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8554–8559. Published online 2001 July 3. doi: 10.1073/pnas.141230798.
PMCID: PMC37474
Old yellow enzyme: Reduction of nitrate esters, glycerin trinitrate, and propylene 1,2-dinitrate
Younus Meah, Bette Jo Brown, Sumita Chakraborty, and Vincent Massey
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8560–8565. Published online 2001 July 3. doi: 10.1073/pnas.151249098.
PMCID: PMC37475
Mechanism of DNA polymerase II-mediated frameshift mutagenesis
Olivier J. Becherel and Robert P. P. Fuchs
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8566–8571. Published online 2001 July 10. doi: 10.1073/pnas.141113398.
PMCID: PMC37476
In vitro generated antibodies specific for telomeric guanine-quadruplex DNA react with Stylonychia lemnae macronuclei
Christiane Schaffitzel, Imre Berger, Jan Postberg, Jozef Hanes, Hans J. Lipps, and Andreas Plückthun
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8572–8577. Published online 2001 July 3. doi: 10.1073/pnas.141229498.
PMCID: PMC37477
Critical role for the docking-protein FRS2α in FGF receptor-mediated signal transduction pathways
Y. R. Hadari, N. Gotoh, H. Kouhara, I. Lax, and J. Schlessinger
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8578–8583. Published online 2001 July 10. doi: 10.1073/pnas.161259898.
PMCID: PMC37478
Sir3-dependent assembly of supramolecular chromatin structures in vitro
Philippe T. Georgel, Madeleine A. Palacios DeBeer, Gregory Pietz, Catherine A. Fox, and Jeffrey C. Hansen
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8584–8589. Published online 2001 July 10. doi: 10.1073/pnas.151258798.
PMCID: PMC37479
Multiple vesiculoviral matrix proteins inhibit both nuclear export and import
Jeannine M. Petersen, Lu-Shiun Her, and James E. Dahlberg
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8590–8595. Published online 2001 July 10. doi: 10.1073/pnas.151240998.
PMCID: PMC37480
Physical and functional interactions between Drosophila TRAF2 and Pelle kinase contribute to Dorsal activation
Baohe Shen, H. Liu, Edward Y. Skolnik, and James L. Manley
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8596–8601. Published online 2001 July 10. doi: 10.1073/pnas.141235698.
PMCID: PMC37481
Biophysics
The relaxation dynamics of the excited electronic states of retinal in bacteriorhodopsin by two-pump-probe femtosecond studies
S. L. Logunov, V. V. Volkov, M. Braun, and M. A. El-Sayed
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8475–8479. Published online 2001 July 10. doi: 10.1073/pnas.141220198.
PMCID: PMC37460
Tuning DNA “strings”: Modulating the rate of DNA replication with mechanical tension
Anita Goel, Maxim D. Frank-Kamenetskii, Tom Ellenberger, and Dudley Herschbach
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8485–8489. Published online 2001 July 10. doi: 10.1073/pnas.151261198.
PMCID: PMC37462
Excited-state dynamics in photosystem II: Insights from the x-ray crystal structure
Sergej Vasil'ev, Peter Orth, Athina Zouni, Thomas G. Owens, and Doug Bruce
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8602–8607. doi: 10.1073/pnas.141239598.
PMCID: PMC37482
Force and kinetic barriers to unzipping of the DNA double helix
Simona Cocco, Rémi Monasson, and John F. Marko
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8608–8613. Published online 2001 July 10. doi: 10.1073/pnas.151257598.
PMCID: PMC37483
Intrinsic noise in gene regulatory networks
Mukund Thattai and Alexander van Oudenaarden
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8614–8619. Published online 2001 July 3. doi: 10.1073/pnas.151588598.
PMCID: PMC37484
Computer-modeling origin of a simple genetic apparatus
Christoph Kuhn
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8620–8625. doi: 10.1073/pnas.141379398.
PMCID: PMC37485
Cell Biology
Telomerase expression and activity are coupled with myocyte proliferation and preservation of telomeric length in the failing heart
Annarosa Leri, Laura Barlucchi, Federica Limana, Andrzej Deptala, Zbigniew Darzynkiewicz, Thomas H. Hintze, Jan Kajstura, Bernardo Nadal-Ginard, and Piero Anversa
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8626–8631. Published online 2001 July 10. doi: 10.1073/pnas.151013298.
PMCID: PMC37486
Contact interactions between epitheliocytes and fibroblasts: Formation of heterotypic cadherin-containing adhesion sites is accompanied by local cytoskeletal reorganization
T. Omelchenko, E. Fetisova, O. Ivanova, E. M. Bonder, H. Feder, J. M. Vasiliev, and I. M. Gelfand
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8632–8637. Published online 2001 July 10. doi: 10.1073/pnas.151247698.
PMCID: PMC37487
Complex regulation of human inducible nitric oxide synthase gene transcription by Stat 1 and NF-κB
Raymond W. Ganster, Bradley S. Taylor, Lifang Shao, and David A. Geller
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8638–8643. Published online 2001 July 3. doi: 10.1073/pnas.151239498.
PMCID: PMC37488
Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining
Fen Xia, Danielle G. Taghian, Jeffrey S. DeFrank, Zhao-Chong Zeng, Henning Willers, George Iliakis, and Simon N. Powell
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8644–8649. Published online 2001 July 10. doi: 10.1073/pnas.151253498.
PMCID: PMC37489
Subnuclear targeting of Runx/Cbfa/AML factors is essential for tissue-specific differentiation during embryonic development
Je-Yong Choi, Jitesh Pratap, Amjad Javed, S. Kaleem Zaidi, Lianping Xing, Eva Balint, Sara Dalamangas, Brendan Boyce, André J. van Wijnen, Jane B. Lian, Janet L. Stein, Stephen N. Jones, and Gary S. Stein
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8650–8655. Published online 2001 July 3. doi: 10.1073/pnas.151236498.
PMCID: PMC37490
Antagonistic forces generated by myosin II and cytoplasmic dynein regulate microtubule turnover, movement, and organization in interphase cells
Anne-Marie C. Yvon, David J. Gross, and Patricia Wadsworth
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8656–8661. Published online 2001 July 3. doi: 10.1073/pnas.141224198.
PMCID: PMC37491
Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death
Yasuyuki Suzuki, Yui Nakabayashi, and Ryosuke Takahashi
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8662–8667. Published online 2001 July 10. doi: 10.1073/pnas.161506698.
PMCID: PMC37492
Developmental Biology
Rescue of a Wnt mutation by an activated form of LEF-1: Regulation of maintenance but not initiation of Brachyury expression
Juan Galceran, Shu-Chi Hsu, and Rudolf Grosschedl
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8668–8673. Published online 2001 July 10. doi: 10.1073/pnas.151258098.
PMCID: PMC37493
Tbx19, a tissue-selective regulator of POMC gene expression
Jianxiang Liu, Chijen Lin, Anatoli Gleiberman, Kenneth A. Ohgi, Thomas Herman, Hsiang-Po Huang, Ming-Jer Tsai, and Michael G. Rosenfeld
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8674–8679. Published online 2001 July 10. doi: 10.1073/pnas.141234898.
PMCID: PMC37494
Dual control of LIF expression and LIF receptor function regulate Stat3 activation at the onset of uterine receptivity and embryo implantation
Jr-Gang Cheng, Jim Ray Chen, Lidia Hernandez, W. Greg Alvord, and Colin L. Stewart
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8680–8685. Published online 2001 July 3. doi: 10.1073/pnas.151180898.
PMCID: PMC37495
Use of cDNA subtraction and RNA interference screens in combination reveals genes required for germ-line development in Caenorhabditis elegans
Momoyo Hanazawa, Makoto Mochii, Naoto Ueno, Yuji Kohara, and Yuichi Iino
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8686–8691. Published online 2001 July 10. doi: 10.1073/pnas.141004698.
PMCID: PMC37496
Evolution
Sexually antagonistic coevolution of a postmating-prezygotic reproductive character in desert Drosophila
L. Lacey Knowles and Therese A. Markow
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8692–8696. Published online 2001 July 10. doi: 10.1073/pnas.151123998.
PMCID: PMC37497
Genetics
Somatic mosaicism in Wiskott–Aldrich syndrome suggests in vivo reversion by a DNA slippage mechanism
Taizo Wada, Shepherd H. Schurman, Makoto Otsu, Elizabeth K. Garabedian, Hans D. Ochs, David L. Nelson, and Fabio Candotti
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8697–8702. Published online 2001 July 10. doi: 10.1073/pnas.151260498.
PMCID: PMC37498
Identification of an autoimmune serum containing antibodies against the Barr body
Bo Hong, Peter Reeves, Barbara Panning, Maurice S. Swanson, and Thomas P. Yang
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8703–8708. Published online 2001 July 3. doi: 10.1073/pnas.151259598.
PMCID: PMC37499
An antisense approach to phenotype-based gene cloning in Tetrahymena
N. Doane Chilcoat, Nels C. Elde, and Aaron P. Turkewitz
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8709–8713. Published online 2001 July 3. doi: 10.1073/pnas.151243498.
PMCID: PMC37500
Rolling-circle transposons in eukaryotes
Vladimir V. Kapitonov and Jerzy Jurka
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8714–8719. Published online 2001 July 10. doi: 10.1073/pnas.151269298.
PMCID: PMC37501
Histone deacetylase-dependent transcriptional repression by pRB in yeast occurs independently of interaction through the LXCXE binding cleft
Brian K. Kennedy, Oliver W. Liu, Fred A. Dick, Nick Dyson, Ed Harlow, and Marc Vidal
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8720–8725. Published online 2001 July 10. doi: 10.1073/pnas.151240898.
PMCID: PMC37502
A two-hybrid system for transactivator bait proteins
Martin Hirst, Cynthia Ho, Luc Sabourin, Michael Rudnicki, Linda Penn, and Ivan Sadowski
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8726–8731. Published online 2001 July 10. doi: 10.1073/pnas.141413598.
PMCID: PMC37503
Immunology
IL-7 is critical for homeostatic proliferation and survival of naïve T cells
Joyce T. Tan, Eric Dudl, Eric LeRoy, Richard Murray, Jonathan Sprent, Kenneth I. Weinberg, and Charles D. Surh
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8732–8737. Published online 2001 July 10. doi: 10.1073/pnas.161126098.
PMCID: PMC37504
Regulatory function of in vivo anergized CD4+ T cells
Karin Jooss, Bernard Gjata, Olivier Danos, Harald von Boehmer, and Adelaida Sarukhan
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8738–8743. Published online 2001 July 3. doi: 10.1073/pnas.151088898.
PMCID: PMC37505
How αβ T cells deal with induced TCRα ablation
Bojan Polic, Desiree Kunkel, Alexander Scheffold, and Klaus Rajewsky
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8744–8749. Published online 2001 July 10. doi: 10.1073/pnas.141218898.
PMCID: PMC37506
A role for CD36 in the regulation of dendritic cell function
Britta C. Urban, Nick Willcox, and David J. Roberts
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8750–8755. Published online 2001 July 10. doi: 10.1073/pnas.151028698.
PMCID: PMC37507
Medical Sciences
The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia
Uta Fuchs, Gönna Rehkamp, Oskar A. Haas, Robert Slany, Margit König, Stig Bojesen, Rainer M. Bohle, Christine Damm-Welk, Wolf-Dieter Ludwig, Jochen Harbott, and Arndt Borkhardt
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8756–8761. Published online 2001 July 3. doi: 10.1073/pnas.121433898.
PMCID: PMC37508
A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice
Toshiyuki Kobayashi, Osamu Minowa, Yoshinobu Sugitani, Setsuo Takai, Hiroaki Mitani, Etsuko Kobayashi, Tetsuo Noda, and Okio Hino
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8762–8767. Published online 2001 July 3. doi: 10.1073/pnas.151033798.
PMCID: PMC37509
Demonstration of the extrinsic coagulation pathway in teleostei: Identification of zebrafish coagulation factor VII
John Sheehan, Michael Templer, Michael Gregory, Ravikumar Hanumanthaiah, Dean Troyer, Thao Phan, Bharath Thankavel, and Pudur Jagadeeswaran
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8768–8773. doi: 10.1073/pnas.131109398.
PMCID: PMC37510
Activation of NF-κB by nontypeable Hemophilus influenzae is mediated by toll-like receptor 2-TAK1-dependent NIK–IKKα/β–IκBα and MKK3/6–p38 MAP kinase signaling pathways in epithelial cells
Tsuyoshi Shuto, Haidong Xu, Beinan Wang, Jiahuai Han, Hirofumi Kai, Xin-Xing Gu, Timothy F. Murphy, David J. Lim, and Jian-Dong Li
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8774–8779. Published online 2001 July 3. doi: 10.1073/pnas.151236098.
PMCID: PMC37511
From the Cover:
Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice
Gaël Nicolas, Myriam Bennoun, Isabelle Devaux, Carole Beaumont, Bernard Grandchamp, Axel Kahn, and Sophie Vaulont
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8780–8785. Published online 2001 July 10. doi: 10.1073/pnas.151179498.
PMCID: PMC37512
TAT peptide on the surface of liposomes affords their efficient intracellular delivery even at low temperature and in the presence of metabolic inhibitors
Vladimir P. Torchilin, Ram Rammohan, Volkmar Weissig, and Tatyana S. Levchenko
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8786–8791. Published online 2001 July 3. doi: 10.1073/pnas.151247498.
PMCID: PMC37513
Altered potassium balance and aldosterone secretion in a mouse model of human congenital long QT syndrome
Isabelle Arrighi, May Bloch-Faure, Florian Grahammer, Markus Bleich, Richard Warth, Raymond Mengual, Milou-Daniel Drici, Jacques Barhanin, and Pierre Meneton
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8792–8797. Published online 2001 July 3. doi: 10.1073/pnas.141233398.
PMCID: PMC37514
Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia
Tohru Minamino, Helen Christou, Chung-Ming Hsieh, Yuxiang Liu, Vijender Dhawan, Nader G. Abraham, Mark A. Perrella, S. Alex Mitsialis, and Stella Kourembanas
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8798–8803. Published online 2001 July 10. doi: 10.1073/pnas.161272598.
PMCID: PMC37515
Enhanced antitumor efficacy of a herpes simplex virus mutant isolated by genetic selection in cancer cells
Samir Taneja, Jennifer MacGregor, Steven Markus, Susan Ha, and Ian Mohr
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8804–8808. Published online 2001 July 3. doi: 10.1073/pnas.161011798.
PMCID: PMC37516
Altered peptide ligand vaccination with Flt3 ligand expanded dendritic cells for tumor immunotherapy
Lawrence Fong, Yafei Hou, Alberto Rivas, Claudia Benike, Alan Yuen, George A. Fisher, Mark M. Davis, and Edgar G. Engleman
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8809–8814. Published online 2001 June 26. doi: 10.1073/pnas.141226398.
PMCID: PMC37517
Microbiology
The infected cell protein 0 of herpes simplex virus 1 dynamically interacts with proteasomes, binds and activates the cdc34 E2 ubiquitin-conjugating enzyme, and possesses in vitro E3 ubiquitin ligase activity
Charles Van Sant, Ryan Hagglund, Pascal Lopez, and Bernard Roizman
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8815–8820. Published online 2001 July 10. doi: 10.1073/pnas.161283098.
PMCID: PMC37518
Evolutionary genomics of Staphylococcus aureus: Insights into the origin of methicillin-resistant strains and the toxic shock syndrome epidemic
J. Ross Fitzgerald, Daniel E. Sturdevant, Stacy M. Mackie, Steven R. Gill, and James M. Musser
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8821–8826. Published online 2001 July 10. doi: 10.1073/pnas.161098098.
PMCID: PMC37519
Neurobiology
Lightness constancy in primary visual cortex
Sean P. MacEvoy and Michael A. Paradiso
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8827–8831. Published online 2001 July 10. doi: 10.1073/pnas.161280398.
PMCID: PMC37520
Rapid induction of intraneuronal neurofibrillary tangles in apolipoprotein E-deficient mice
Xiaoning Bi, Alex P. Yong, Jun Zhou, Charles E. Ribak, and Gary Lynch
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8832–8837. Published online 2001 July 3. doi: 10.1073/pnas.151253098.
PMCID: PMC37521
Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons
Yadong Huang, Xiao Qin Liu, Tony Wyss-Coray, Walter J. Brecht, David A. Sanan, and Robert W. Mahley
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8838–8843. Published online 2001 July 10. doi: 10.1073/pnas.151254698.
PMCID: PMC37522
A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P
Annette Schenck, Barbara Bardoni, Annamaria Moro, Claudia Bagni, and Jean-Louis Mandel
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8844–8849. Published online 2001 July 3. doi: 10.1073/pnas.151231598.
PMCID: PMC37523
Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease
Ronald B. DeMattos, Kelly R. Bales, David J. Cummins, Jean-Cosme Dodart, Steven M. Paul, and David M. Holtzman
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8850–8855. Published online 2001 July 3. doi: 10.1073/pnas.151261398.
PMCID: PMC37524
Long-term, progressive hippocampal cell loss and dysfunction induced by early-life administration of corticotropin-releasing hormone reproduce the effects of early-life stress
Kristen L. Brunson, Mariam Eghbal-Ahmadi, Roland Bender, Yuncai Chen, and Tallie Z. Baram
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8856–8861. Published online 2001 July 10. doi: 10.1073/pnas.151224898.
PMCID: PMC37525
Genome-wide gene expression profiles of the developing mouse hippocampus
Monica Mody, Yanxiang Cao, Zhenzhong Cui, Khoon-Yen Tay, Andy Shyong, Eiji Shimizu, Kelvin Pham, Peter Schultz, Douglas Welsh, and Joe Z. Tsien
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8862–8867. Published online 2001 July 3. doi: 10.1073/pnas.141244998.
PMCID: PMC37526
Dominant loss of responsiveness to sweet and bitter compounds caused by a single mutation in α-gustducin
Luis Ruiz-Avila, Gwendolyn T. Wong, Sami Damak, and Robert F. Margolskee
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8868–8873. Published online 2001 July 10. doi: 10.1073/pnas.151235798.
PMCID: PMC37527
Long-term plasticity in interneurons of the dentate gyrus
Stephen T. Ross and Ivan Soltesz
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8874–8879. Published online 2001 July 3. doi: 10.1073/pnas.141042398.
PMCID: PMC37528
Pharmacology
4-Hydroxytamoxifen binds to and deactivates the estrogen-related receptor γ
Peter Coward, Doris Lee, Mitchell V. Hull, and Jürgen M. Lehmann
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8880–8884. Published online 2001 July 10. doi: 10.1073/pnas.151244398.
PMCID: PMC37529
Physiology
Prostaglandins are required for CREB activation and cellular proliferation during liver regeneration
David A. Rudnick, David H. Perlmutter, and Louis J. Muglia
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8885–8890. Published online 2001 July 10. doi: 10.1073/pnas.151217998.
PMCID: PMC37530
Folliculostellate cell network: A route for long-distance communication in the anterior pituitary
Teddy Fauquier, Nathalie C. Guérineau, R. Anne McKinney, Karl Bauer, and Patrice Mollard
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8891–8896. Published online 2001 July 3. doi: 10.1073/pnas.151339598.
PMCID: PMC37531
NCX-1000, a NO-releasing derivative of ursodeoxycholic acid, selectively delivers NO to the liver and protects against development of portal hypertension
Stefano Fiorucci, Elisabetta Antonelli, Olivia Morelli, Andrea Mencarelli, Alessandro Casini, Tommaso Mello, Barbara Palazzetti, Dominique Tallet, Piero del Soldato, and Antonio Morelli
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8897–8902. Published online 2001 July 10. doi: 10.1073/pnas.151136298.
PMCID: PMC37532
Plant Biology
From the Cover:
The highly recombinogenic bz locus lies in an unusually gene-rich region of the maize genome
Huihua Fu, Wonkeun Park, Xianghe Yan, Zhenwei Zheng, Binzhang Shen, and Hugo K. Dooner
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8903–8908. Published online 2001 July 3. doi: 10.1073/pnas.141221898.
PMCID: PMC37533
Cloning and functional analysis of two gibberellin 3β-hydroxylase genes that are differently expressed during the growth of rice
Hironori Itoh, Miyako Ueguchi-Tanaka, Naoki Sentoku, Hidemi Kitano, Makoto Matsuoka, and Masatomo Kobayashi
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8909–8914. Published online 2001 July 3. doi: 10.1073/pnas.141239398.
PMCID: PMC37534
From the Cover:
Metabolic engineering of essential oil yield and composition in mint by altering expression of deoxyxylulose phosphate reductoisomerase and menthofuran synthase
Soheil S. Mahmoud and Rodney B. Croteau
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8915–8920. Published online 2001 June 26. doi: 10.1073/pnas.141237298.
PMCID: PMC37535
Correction
Correction
Wojciech Rzeski, Lechoslaw Turski, and Chrysanthy Ikonomidou
Proc Natl Acad Sci U S A. 2001 July 17; 98(15): 8921. Published online 2001 July 10.
PMCID: PMC55970
Corrects: Wojciech Rzeski, et al. From the Cover:
Glutamate antagonists limit tumor growth.
Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6372–6377.
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