| | This journal provides immediate access to some articles. Commentaries FGF23, hypophosphatemia, and rickets: Has phosphatonin been
found? Gordon J. Strewler Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 5945–5946. doi: 10.1073/pnas.111154898.PMCID: PMC33399 Glutamate antagonists: Deadly liaisons with cancer Esper A. Cavalheiro and John W. Olney Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 5947–5948. doi: 10.1073/pnas.121179198.PMCID: PMC33400 Factors affecting the developmental potential of cloned
mammalian embryos James C. Cross Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 5949–5951. doi: 10.1073/pnas.111182398.PMCID: PMC33401 BRCA1 at a branch point Jeffrey D. Parvin Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 5952–5954. doi: 10.1073/pnas.121184998.PMCID: PMC33402 A new picture of life's history on Earth Mark Newman Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 5955–5956. doi: 10.1073/pnas.121190498.PMCID: PMC33403 Perspective Precision in mouse behavior genetics Donald Pfaff Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 5957–5960. Published online 2001 May 8. doi: 10.1073/pnas.101128598.PMCID: PMC33404 Physical Sciences Chemistry Large vortex-like structure of dipole field in computer
models of liquid water and dipole-bridge between biomolecules Junichi Higo, Masaki Sasai, Hiroki Shirai, Haruki Nakamura, and Takaki Kugimiya Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 5961–5964. Published online 2001 May 8. doi: 10.1073/pnas.101516298.PMCID: PMC33405 Quantification of the hydrophobic interaction by simulations of
the aggregation of small hydrophobic solutes in water Tanya M. Raschke, Jerry Tsai, and Michael Levitt Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 5965–5969. Published online 2001 May 15. doi: 10.1073/pnas.111158498.PMCID: PMC33406 Designing surfaces that kill bacteria on contact Joerg C. Tiller, Chun-Jen Liao, Kim Lewis, and Alexander M. Klibanov Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 5981–5985. Published online 2001 May 15. doi: 10.1073/pnas.111143098.PMCID: PMC33409 Geology Nondestructive, in situ, cellular-scale mapping of
elemental abundances including organic carbon in permineralized
fossils C. K. Boyce, R. M. Hazen, and A. H. Knoll Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 5970–5974. doi: 10.1073/pnas.101130598.PMCID: PMC33407 Geophysics Desert dust suppressing precipitation: A possible desertification
feedback loop Daniel Rosenfeld, Yinon Rudich, and Ronen Lahav Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 5975–5980. Published online 2001 May 15. doi: 10.1073/pnas.101122798.PMCID: PMC33408 Biological Sciences Applied Biological Sciences Designing surfaces that kill bacteria on contact Joerg C. Tiller, Chun-Jen Liao, Kim Lewis, and Alexander M. Klibanov Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 5981–5985. Published online 2001 May 15. doi: 10.1073/pnas.111143098.PMCID: PMC33409 An improved helper-dependent adenoviral vector allows persistent
gene expression after intramuscular delivery and overcomes preexisting immunity to adenovirus Domenico Maione, Carlo Della Rocca, Patrizia Giannetti, Roberta D'Arrigo, Laura Liberatoscioli, Laura L. Franlin, Volker Sandig, Gennaro Ciliberto, Nicola La Monica, and Rocco Savino Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 5986–5991. Published online 2001 May 15. doi: 10.1073/pnas.101122498.PMCID: PMC33410 Using electroactive substrates to pattern the attachment of two
different cell populations Muhammad N. Yousaf, Benjamin T. Houseman, and Milan Mrksich Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 5992–5996. Published online 2001 May 15. doi: 10.1073/pnas.101112898.PMCID: PMC33411 Biochemistry Agonist-induced conformational changes in the G-protein-coupling
domain of the β2 adrenergic receptor Pejman Ghanouni, Jacqueline J. Steenhuis, David L. Farrens, and Brian K. Kobilka Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 5997–6002. Published online 2001 May 15. doi: 10.1073/pnas.101126198.PMCID: PMC33412 Conformational coupling in the chemotaxis response
regulator CheY Martin Schuster, Ruth E. Silversmith, and Robert B. Bourret Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6003–6008. Published online 2001 May 15. doi: 10.1073/pnas.101571298.PMCID: PMC33503 Reversibly locking a protein fold in an active conformation with
a disulfide bond: Integrin αL I domains with high affinity
and antagonist activity in vivo Motomu Shimaoka, Chafen Lu, Roger T. Palframan, Ulrich H. von Andrian, Alison McCormack, Junichi Takagi, and Timothy A. Springer Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6009–6014. Published online 2001 May 15. doi: 10.1073/pnas.101130498.PMCID: PMC33413 A type IB topoisomerase with DNA repair activities Galina I. Belova, Rajendra Prasad, Sergei A. Kozyavkin, James A. Lake, Samuel H. Wilson, and Alexei I. Slesarev Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6015–6020. Published online 2001 May 15. doi: 10.1073/pnas.111040498.PMCID: PMC33414 The structures of anthranilate synthase of Serratia
marcescens crystallized in the presence of
(i) its substrates, chorismate and glutamine, and
a product, glutamate, and (ii) its
end-product inhibitor, l-tryptophan Glen Spraggon, Choel Kim, Xuong Nguyen-Huu, Muh-Ching Yee, Charles Yanofsky, and Stanley E. Mills Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6021–6026. doi: 10.1073/pnas.111150298.PMCID: PMC33415 Unsaturated fatty acids inhibit transcription of the sterol
regulatory element-binding protein-1c (SREBP-1c) gene by
antagonizing ligand-dependent activation of the LXR Jiafu Ou, Hua Tu, Bei Shan, Alvin Luk, Russell A. DeBose-Boyd, Yuriy Bashmakov, Joseph L. Goldstein, and Michael S. Brown Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6027–6032. doi: 10.1073/pnas.111138698.PMCID: PMC33416 The arginine finger of RasGAP helps Gln-61 align the
nucleophilic water in GAP-stimulated hydrolysis of GTP Haluk Resat, T. P. Straatsma, David A. Dixon, and John H. Miller Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6033–6038. doi: 10.1073/pnas.091506998.PMCID: PMC33417 Strong DNA binding by covalently linked dimeric Lac headpiece:
Evidence for the crucial role of the hinge helices Charalampos G. Kalodimos, Gert E. Folkers, Rolf Boelens, and Robert Kaptein Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6039–6044. Published online 2001 May 15. doi: 10.1073/pnas.101129898.PMCID: PMC33418 Corepressor-induced organization and assembly of the biotin
repressor: A model for allosteric activation of a transcriptional
regulator Larry H. Weaver, Keehwan Kwon, Dorothy Beckett, and Brian W. Matthews Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6045–6050. Published online 2001 May 15. doi: 10.1073/pnas.111128198.PMCID: PMC33419 Solution structure of DFF40 and DFF45 N-terminal domain complex
and mutual chaperone activity of DFF40 and DFF45 Pei Zhou, Alexey A. Lugovskoy, John S. McCarty, Peng Li, and Gerhard Wagner Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6051–6055. doi: 10.1073/pnas.111145098.PMCID: PMC33420 Structure of sortase, the transpeptidase that anchors proteins to
the cell wall of Staphylococcus aureus Udayar Ilangovan, Hung Ton-That, Junji Iwahara, Olaf Schneewind, and Robert T. Clubb Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6056–6061. doi: 10.1073/pnas.101064198.PMCID: PMC33421 Catalytic efficiency and vitality of HIV-1 proteases from African
viral subtypes Adrian Velazquez-Campoy, Matthew J. Todd, Sonia Vega, and Ernesto Freire Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6062–6067. Published online 2001 May 15. doi: 10.1073/pnas.111152698.PMCID: PMC33422 Arg-302 facilitates deprotonation of Glu-325 in the transport
mechanism of the lactose permease from
Escherichia coli Miklós Sahin-Tóth and H. Ronald Kaback Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6068–6073. Published online 2001 May 15. doi: 10.1073/pnas.111139698.PMCID: PMC33423 Stimulation of phosphatidylinositol 3-kinase by fibroblast
growth factor receptors is mediated by coordinated recruitment of multiple docking proteins S. H. Ong, Y. R. Hadari, N. Gotoh, G. R. Guy, J. Schlessinger, and I. Lax Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6074–6079. Published online 2001 May 15. doi: 10.1073/pnas.111114298.PMCID: PMC33424 Five subunits are required for reconstitution of the cleavage
and polyadenylation activities of Saccharomyces
cerevisiae cleavage factor I Stefan Gross and Claire Moore Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6080–6085. Published online 2001 May 8. doi: 10.1073/pnas.101046598.PMCID: PMC33425 From the Cover: Direct DNA binding by Brca1 Tanya T. Paull, David Cortez, Blair Bowers, Stephen J. Elledge, and Martin Gellert Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6086–6091. Published online 2001 May 15. doi: 10.1073/pnas.111125998.PMCID: PMC33426 Point mutations in a nucleoside transporter gene from
Leishmania donovani confer drug resistance and alter
substrate selectivity Gayatri Vasudevan, Buddy Ullman, and Scott M. Landfear Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6092–6097. Published online 2001 May 15. doi: 10.1073/pnas.101537298.PMCID: PMC33427 Biophysics Top-down free-energy minimization on protein potential energy
landscapes Bruce W. Church and David Shalloway Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6098–6103. Published online 2001 May 8. doi: 10.1073/pnas.101030498.PMCID: PMC33428 Three-dimensional reconstruction of the recombinant type 3
ryanodine receptor and localization of its amino terminus Zheng Liu, Jing Zhang, Manjuli R. Sharma, Pin Li, S. R. Wayne Chen, and Terence Wagenknecht Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6104–6109. Published online 2001 May 15. doi: 10.1073/pnas.111382798.PMCID: PMC33429 Diffractive optics-based heterodyne-detected four-wave mixing
signals of protein motion: From “protein quakes” to ligand
escape for myoglobin Gami Dadusc, Jennifer P. Ogilvie, Peter Schulenberg, Una Marvet, and R. J. Dwayne Miller Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6110–6115. Published online 2001 May 8. doi: 10.1073/pnas.101130298.PMCID: PMC33430 Crystal cataracts: Human genetic cataract caused by
protein crystallization Ajay Pande, Jayanti Pande, Neer Asherie, Aleksey Lomakin, Olutayo Ogun, Jonathan King, and George B. Benedek Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6116–6120. doi: 10.1073/pnas.101124798.PMCID: PMC33431 Mechanism for nucleic acid chaperone activity of HIV-1
nucleocapsid protein revealed by single molecule stretching Mark C. Williams, Ioulia Rouzina, Jay R. Wenner, Robert J. Gorelick, Karin Musier-Forsyth, and Victor A. Bloomfield Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6121–6126. Published online 2001 May 8. doi: 10.1073/pnas.101033198.PMCID: PMC33432 The pKa of His-24 in the folding transition state
of apomyoglobin Marc Jamin, Bernhard Geierstanger, and Robert L. Baldwin Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6127–6131. Published online 2001 May 15. doi: 10.1073/pnas.111157998.PMCID: PMC33433 Cell Biology Maintenance of caspase-3 proenzyme dormancy by an intrinsic
“safety catch” regulatory tripeptide Sophie Roy, Christopher I. Bayly, Yves Gareau, Vicky M. Houtzager, Stacia Kargman, Sabina L. C. Keen, Kathleen Rowland, Isolde M. Seiden, Nancy A. Thornberry, and Donald W. Nicholson Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6132–6137. Published online 2001 May 15. doi: 10.1073/pnas.111085198.PMCID: PMC33434 Antiviral activities of the soluble extracellular domains of type
I interferon receptors Chun-Sheng Han, Yizhen Chen, Toshihiko Ezashi, and R. Michael Roberts Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6138–6143. Published online 2001 May 8. doi: 10.1073/pnas.111139598.PMCID: PMC33435 Drosophila phosphoinositide-dependent kinase-1
regulates apoptosis and growth via the phosphoinositide
3-kinase-dependent signaling pathway Kyoung Sang Cho, Jun Hee Lee, Sunhong Kim, Dohoon Kim, Hyongjong Koh, Jihyun Lee, Changsoo Kim, Jaeseob Kim, and Jongkyeong Chung Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6144–6149. Published online 2001 May 8. doi: 10.1073/pnas.101596998.PMCID: PMC33436 Mutant G protein α subunit activated by Gβγ: A model
for receptor activation? Philippe Rondard, Taroh Iiri, Supriya Srinivasan, Elaine Meng, Toshiro Fujita, and Henry R. Bourne Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6150–6155. Published online 2001 May 8. doi: 10.1073/pnas.101136198.PMCID: PMC33437 Desmuslin, an intermediate filament protein that interacts with
α-dystrobrevin and desmin Yuji Mizuno, Terri G. Thompson, Jeffrey R. Guyon, Hart G. W. Lidov, Melissa Brosius, Michihiro Imamura, Eijiro Ozawa, Simon C. Watkins, and Louis M. Kunkel Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6156–6161. Published online 2001 May 15. doi: 10.1073/pnas.111153298.PMCID: PMC33438 Nerve growth factor displays stimulatory effects on human skin
and lung fibroblasts, demonstrating a direct role for this factor in
tissue repair Alessandra Micera, Eliana Vigneti, Dalia Pickholtz, Reuven Reich, Orit Pappo, Sergio Bonini, François Xavier Maquart, Luigi Aloe, and Francesca Levi-Schaffer Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6162–6167. Published online 2001 May 8. doi: 10.1073/pnas.101130898.PMCID: PMC33439 Pro-apoptotic gene expression mediated by the p38
mitogen-activated protein kinase signal transduction pathway Gerard S. De Zutter and Roger J. Davis Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6168–6173. Published online 2001 May 8. doi: 10.1073/pnas.111027698.PMCID: PMC33440 Regulation of the p21-activated kinase (PAK) by a human Gβ-like
WD-repeat protein, hPIP1 Chunzhi Xia, Wenbin Ma, Lewis Joe Stafford, Stevan Marcus, Wen-Cheng Xiong, and Mingyao Liu Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6174–6179. doi: 10.1073/pnas.101137298.PMCID: PMC33441 Mechanical stress is communicated between different cell types to
elicit matrix remodeling M. A. Swartz, D. J. Tschumperlin, R. D. Kamm, and J. M. Drazen Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6180–6185. Published online 2001 May 15. doi: 10.1073/pnas.111133298.PMCID: PMC33442 From the Cover: Remodeling of the postnatal mouse testis is accompanied by
dramatic changes in stem cell number and niche accessibility Takashi Shinohara, Kyle E. Orwig, Mary R. Avarbock, and Ralph L. Brinster Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6186–6191. doi: 10.1073/pnas.111158198.PMCID: PMC33443 RhoB is required to mediate apoptosis in neoplastically
transformed cells after DNA damage Ai-xue Liu, George J. Cerniglia, Eric J. Bernhard, and George C. Prendergast Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6192–6197. Published online 2001 May 15. doi: 10.1073/pnas.111137198.PMCID: PMC33444 c-Jun interacts with the corepressor TG-interacting factor (TGIF)
to suppress Smad2 transcriptional activity Marcia Pessah, Céline Prunier, Jacqueline Marais, Nathalie Ferrand, Anne Mazars, François Lallemand, Jean-Michel Gauthier, and Azeddine Atfi Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6198–6203. doi: 10.1073/pnas.101579798.PMCID: PMC33445 Developmental Biology CtBP-dependent activities of the short-range Giant repressor in
the Drosophila embryo Yutaka Nibu and Michael S. Levine Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6204–6208. Published online 2001 May 15. doi: 10.1073/pnas.111158298.PMCID: PMC33446 Hybrid vigor, fetal overgrowth, and viability of mice derived by
nuclear cloning and tetraploid embryo complementation Kevin Eggan, Hidenori Akutsu, Janet Loring, Laurie Jackson-Grusby, Martina Klemm, William M. Rideout, 3rd, Ryuzo Yanagimachi, and Rudolf Jaenisch Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6209–6214. Published online 2001 May 1. doi: 10.1073/pnas.101118898.PMCID: PMC33447 Ecology Biomechanics of the movable pretarsal adhesive organ in ants
and bees Walter Federle, Elizabeth L. Brainerd, Thomas A. McMahon, and Bert Hölldobler Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6215–6220. Published online 2001 May 15. doi: 10.1073/pnas.111139298.PMCID: PMC33448 Evolution Insect herbivory, plant defense, and early Cenozoic climate
change Peter Wilf, Conrad C. Labandeira, Kirk R. Johnson, Phyllis D. Coley, and Asher D. Cutter Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6221–6226. Published online 2001 May 15. doi: 10.1073/pnas.111069498.PMCID: PMC33449 The evolution of coloration and toxicity in the poison frog
family (Dendrobatidae) Kyle Summers and Mark E. Clough Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6227–6232. Published online 2001 May 15. doi: 10.1073/pnas.101134898.PMCID: PMC33450 INAUGURAL ARTICLE by a Recently Elected Academy Member: Evolution of genome–phenome diversity under
environmental stress Eviatar Nevo Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6233–6240. doi: 10.1073/pnas.101109298.PMCID: PMC33451 Integrated fossil and molecular data reconstruct bat
echolocation Mark S. Springer, Emma C. Teeling, Ole Madsen, Michael J. Stanhope, and Wilfried W. de Jong Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6241–6246. Published online 2001 May 15. doi: 10.1073/pnas.111551998.PMCID: PMC33452 Removing symbiotic Wolbachia bacteria specifically
inhibits oogenesis in a parasitic wasp Franck Dedeine, Fabrice Vavre, Frédéric Fleury, Benjamin Loppin, Michael E. Hochberg, and Michel Boulétreau Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6247–6252. Published online 2001 May 15. doi: 10.1073/pnas.101304298.PMCID: PMC33453 Negative frequency-dependent selection maintains a dramatic
flower color polymorphism in the rewardless orchid
Dactylorhiza sambucina (L.) Soò Luc D. B. Gigord, Mark R. Macnair, and Ann Smithson Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6253–6255. Published online 2001 May 15. doi: 10.1073/pnas.111162598.PMCID: PMC33454 Rapid, local adaptation of zooplankton behavior to changes in
predation pressure in the absence of neutral genetic changes C. Cousyn, L. De Meester, J. K. Colbourne, L. Brendonck, D. Verschuren, and F. Volckaert Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6256–6260. Published online 2001 May 15. doi: 10.1073/pnas.111606798.PMCID: PMC33455 From the Cover: Effects of sampling standardization on estimates of Phanerozoic
marine diversification J. Alroy, C. R. Marshall, R. K. Bambach, K. Bezusko, M. Foote, F. T. Fürsich, T. A. Hansen, S. M. Holland, L. C. Ivany, D. Jablonski, D. K. Jacobs, D. C. Jones, M. A. Kosnik, S. Lidgard, S. Low, A. I. Miller, P. M. Novack-Gottshall, T. D. Olszewski, M. E. Patzkowsky, D. M. Raup, K. Roy, J. J. Sepkoski, Jr., M. G. Sommers, P. J. Wagner, and A. Webber Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6261–6266. Published online 2001 May 15. doi: 10.1073/pnas.111144698.PMCID: PMC33456 Genetics BimD/SPO76 is at the interface of cell cycle
progression, chromosome morphogenesis, and recombination Diana van Heemst, Etta Käfer, Tricia John, Christa Heyting, Mirjam van Aalderen, and Denise Zickler Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6267–6272. Published online 2001 May 15. doi: 10.1073/pnas.081088498.PMCID: PMC33457 Painting of fourth, a chromosome-specific protein
in Drosophila Jan Larsson, J. Don Chen, Vanya Rasheva, Åsa Rasmuson-Lestander, and Vincenzo Pirrotta Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6273–6278. Published online 2001 May 15. doi: 10.1073/pnas.111581298.PMCID: PMC33458 Identification of multiple quantitative trait loci linked to
prion disease incubation period in mice Sarah E. Lloyd, Obia N. Onwuazor, Jonathan A. Beck, Gary Mallinson, Martin Farrall, Paul Targonski, John Collinge, and Elizabeth M. C. Fisher Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6279–6283. Published online 2001 May 15. doi: 10.1073/pnas.101130398.PMCID: PMC33459 A DAF-1-binding protein BRA-1 is a negative regulator of DAF-7
TGF-β signaling Kiyokazu Morita, Miho Shimizu, Hiroshi Shibuya, and Naoto Ueno Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6284–6288. Published online 2001 May 15. doi: 10.1073/pnas.111409798.PMCID: PMC33460 Generalized transduction in
Streptomyces coelicolor Julie Burke, David Schneider, and Janet Westpheling Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6289–6294. Published online 2001 May 15. doi: 10.1073/pnas.101589398.PMCID: PMC33461 Immunology Developmental plasticity of CNS microglia L. Santambrogio, S. L. Belyanskaya, F. R. Fischer, B. Cipriani, C. F. Brosnan, P. Ricciardi-Castagnoli, L. J. Stern, J. L. Strominger, and R. Riese Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6295–6300. doi: 10.1073/pnas.111152498.PMCID: PMC33462 CD8+ T cells control the TH phenotype of MBP-reactive
CD4+ T cells in EAE mice Hong Jiang, Ned S. Braunstein, Bin Yu, Robert Winchester, and Leonard Chess Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6301–6306. Published online 2001 May 15. doi: 10.1073/pnas.101123098.PMCID: PMC33463 T cell-specific FADD-deficient mice: FADD is required for early T
cell development Nisha H. Kabra, Chulho Kang, Lianne C. Hsing, Jianke Zhang, and Astar Winoto Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6307–6312. Published online 2001 May 15. doi: 10.1073/pnas.111158698.PMCID: PMC33464 Measuring the diaspora for virus-specific CD8+ T
cells Dana R. Marshall, Stephen J. Turner, Gabrielle T. Belz, Suzette Wingo, Samita Andreansky, Mark Y. Sangster, Janice M. Riberdy, Tiebin Liu, Ming Tan, and Peter C. Doherty Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6313–6318. Published online 2001 May 8. doi: 10.1073/pnas.101132698.PMCID: PMC33465 T cell activation up-regulates cyclic nucleotide
phosphodiesterases 8A1 and 7A3 Natalie A. Glavas, Cari Ostenson, Jonathan B. Schaefer, Valeria Vasta, and Joseph A. Beavo Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6319–6324. doi: 10.1073/pnas.101131098.PMCID: PMC33466 Stimulation via CD40 can substitute for CD4 T cell function in
preventing reactivation of a latent herpesvirus Sally R. Sarawar, Bong Joo Lee, Su Khoh Reiter, and Stephen P. Schoenberger Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6325–6329. Published online 2001 May 15. doi: 10.1073/pnas.101136898.PMCID: PMC33467 Medical Sciences A role for estrogen receptor β in the regulation of growth of
the ventral prostate Zhang Weihua, Sari Mäkelä, Leif C. Andersson, Saija Salmi, Shigehira Saji, Jeanette I. Webster, Elwood V. Jensen, Stefan Nilsson, Margaret Warner, and Jan-Åke Gustafsson Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6330–6335. doi: 10.1073/pnas.111150898.PMCID: PMC33468 A rescue factor abolishing neuronal cell death by a wide spectrum
of familial Alzheimer's disease genes and Aβ Yuichi Hashimoto, Takako Niikura, Hirohisa Tajima, Takashi Yasukawa, Haruka Sudo, Yuko Ito, Yoshiko Kita, Masaoki Kawasumi, Keisuke Kouyama, Manabu Doyu, Gen Sobue, Takashi Koide, Shoji Tsuji, Jochen Lang, Kiyoshi Kurokawa, and Ikuo Nishimoto Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6336–6341. doi: 10.1073/pnas.101133498.PMCID: PMC33469 In vitro evolution of a highly replicating,
doxycycline-dependent HIV for applications in vaccine studies Giuseppe Marzio, Koen Verhoef, Monique Vink, and Ben Berkhout Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6342–6347. Published online 2001 May 15. doi: 10.1073/pnas.111031498.PMCID: PMC33470 Frequent fusion of the JAZF1 and
JJAZ1 genes in endometrial stromal tumors Jason I. Koontz, A. Lee Soreng, Marisa Nucci, Frank C. Kuo, Patrick Pauwels, Herman van den
Berghe, Paola Dal Cin, Jonathan A. Fletcher, and Jeffrey Sklar Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6348–6353. doi: 10.1073/pnas.101132598.PMCID: PMC33471 From the Cover: Changes in the prevalence of chronic disability in the United
States black and nonblack population above age 65 from 1982 to 1999 Kenneth G. Manton and XiLiang Gu Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6354–6359. Published online 2001 May 8. doi: 10.1073/pnas.111152298.PMCID: PMC33472 CD147 facilitates HIV-1 infection by interacting with
virus-associated cyclophilin A Tatiana Pushkarsky, Gabriele Zybarth, Larisa Dubrovsky, Vyacheslav Yurchenko, Hao Tang, Huiming Guo, Bryan Toole, Barbara Sherry, and Michael Bukrinsky Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6360–6365. Published online 2001 May 15. doi: 10.1073/pnas.111583198.PMCID: PMC33473 Altered stability of pulmonary surfactant in SP-C-deficient mice Stephan W. Glasser, Michael S. Burhans, Thomas R. Korfhagen, Cheng-Lun Na, Peter D. Sly, Gary F. Ross, Machiko Ikegami, and Jeffrey A. Whitsett Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6366–6371. Published online 2001 May 8. doi: 10.1073/pnas.101500298.PMCID: PMC33474 From the Cover: Glutamate antagonists limit tumor growth Wojciech Rzeski, Lechoslaw Turski, and Chrysanthy Ikonomidou Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6372–6377. Published online 2001 May 1. doi: 10.1073/pnas.091113598.PMCID: PMC33475 Analysis of gene expression during myc
oncogene-induced lymphomagenesis in the bursa of Fabricius Paul E. Neiman, Alanna Ruddell, Christine Jasoni, Gil Loring, Sandra Jo Thomas, Kimberly A. Brandvold, Ruey-min Lee, Joan Burnside, and Jeffrey Delrow Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6378–6383. Published online 2001 May 15. doi: 10.1073/pnas.111144898.PMCID: PMC33476 A missense mutation of the Na+ channel
αII subunit gene
Nav1.2 in a patient with
febrile and afebrile seizures causes channel dysfunction Takashi Sugawara, Yuji Tsurubuchi, Kishan Lal Agarwala, Masatoshi Ito, Goryu Fukuma, Emi Mazaki-Miyazaki, Hiroshi Nagafuji, Masaharu Noda, Keiji Imoto, Kazumaru Wada, Akihisa Mitsudome, Sunao Kaneko, Mauricio Montal, Keiichi Nagata, Shinichi Hirose, and Kazuhiro Yamakawa Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6384–6389. doi: 10.1073/pnas.111065098.PMCID: PMC33477 Leptin induces vascular permeability and synergistically
stimulates angiogenesis with FGF-2 and VEGF Renhai Cao, Ebba Brakenhielm, Claes Wahlestedt, Johan Thyberg, and Yihai Cao Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6390–6395. Published online 2001 May 8. doi: 10.1073/pnas.101564798.PMCID: PMC33478 Oncolytic herpes simplex virus vector with enhanced MHC class I
presentation and tumor cell killing Tomoki Todo, Robert L. Martuza, Samuel D. Rabkin, and Paul A. Johnson Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6396–6401. Published online 2001 May 15. doi: 10.1073/pnas.101136398.PMCID: PMC33479 Anandamide and diet: Inclusion of dietary arachidonate and
docosahexaenoate leads to increased brain levels of the corresponding
N-acylethanolamines in piglets Alvin Berger, Gayle Crozier, Tiziana Bisogno, Paolo Cavaliere, Sheila Innis, and Vincenzo Di Marzo Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6402–6406. Published online 2001 May 15. doi: 10.1073/pnas.101119098.PMCID: PMC33480 Horizontal transfer of oncogenes by uptake of
apoptotic bodies Anna Bergsmedh, Anna Szeles, Marie Henriksson, Anders Bratt, M. Judah Folkman, Anna-Lena Spetz, and Lars Holmgren Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6407–6411. Published online 2001 May 15. doi: 10.1073/pnas.101129998.PMCID: PMC33481 Trypanosoma brucei CTP synthetase: A target for
the treatment of African sleeping sickness Anders Hofer, Dietmar Steverding, Andrei Chabes, Reto Brun, and Lars Thelander Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6412–6416. Published online 2001 May 15. doi: 10.1073/pnas.111139498.PMCID: PMC33482 Neurobiology Precision in mouse behavior genetics Donald Pfaff Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 5957–5960. Published online 2001 May 8. doi: 10.1073/pnas.101128598.PMCID: PMC33404 Cerebral energetics and the glycogen shunt: Neurochemical basis
of functional imaging Robert G. Shulman, Fahmeed Hyder, and Douglas L. Rothman Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6417–6422. Published online 2001 May 8. doi: 10.1073/pnas.101129298.PMCID: PMC33483 Visualization, direct isolation, and transplantation of midbrain
dopaminergic neurons Kazunobu Sawamoto, Naoyuki Nakao, Kazuto Kobayashi, Natsuki Matsushita, Hiroshi Takahashi, Koji Kakishita, Atsuyo Yamamoto, Takahito Yoshizaki, Toshio Terashima, Fujio Murakami, Toru Itakura, and Hideyuki Okano Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6423–6428. Published online 2001 May 15. doi: 10.1073/pnas.111152398.PMCID: PMC33484 Targeted mutagenesis of Lis1 disrupts cortical
development and LIS1 homodimerization Aviv Cahana, Teresa Escamez, Richard S. Nowakowski, Nancy L. Hayes, MaiBritt Giacobini, Alexander von Holst, Orit Shmueli, Tamar Sapir, Susan K. McConnell, Wolfgang Wurst, Salvador Martinez, and Orly Reiner Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6429–6434. Published online 2001 May 8. doi: 10.1073/pnas.101122598.PMCID: PMC33485 Overexpression of p27Kip1 lengthens the
G1 phase in a mouse model that targets inducible gene
expression to central nervous system progenitor cells Takayuki Mitsuhashi, Yoko Aoki, Yaman Z. Eksioglu, Takao Takahashi, Pradeep G. Bhide, Steven A. Reeves, and Verne S. Caviness, Jr. Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6435–6440. doi: 10.1073/pnas.111051398.PMCID: PMC33486 A dendrodendritic reciprocal synapse provides a recurrent
excitatory connection in the olfactory bulb Anne Didier, Alan Carleton, Jan G. Bjaalie, Jean-Didier Vincent, Ole Petter Ottersen, Jon Storm-Mathisen, and Pierre-Marie Lledo Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6441–6446. Published online 2001 May 15. doi: 10.1073/pnas.101126398.PMCID: PMC33487 Refractoriness to melatonin occurs independently at multiple
brain sites in Siberian hamsters David A. Freeman and Irving Zucker Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6447–6452. Published online 2001 May 15. doi: 10.1073/pnas.111140398.PMCID: PMC33488 Requirement of the nicotinic acetylcholine receptor β2 subunit
for the anatomical and functional development of the visual system Francesco Mattia Rossi, Tommaso Pizzorusso, Vittorio Porciatti, Lisa M. Marubio, Lamberto Maffei, and Jean-Pierre Changeux Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6453–6458. Published online 2001 May 8. doi: 10.1073/pnas.101120998.PMCID: PMC33489 DEG/ENaC ion channels involved in sensory transduction are
modulated by cold temperature Candice C. Askwith, Christopher J. Benson, Michael J. Welsh, and Peter M. Snyder Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6459–6463. Published online 2001 May 15. doi: 10.1073/pnas.111155398.PMCID: PMC33490 Pharmacology Diazepam-induced changes in sleep: Role of the α1
GABAA receptor subtype Irene Tobler, Caroline Kopp, Tom Deboer, and Uwe Rudolph Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6464–6469. Published online 2001 May 15. doi: 10.1073/pnas.111055398.PMCID: PMC33491 Platelets modulate gastric ulcer healing: Role of endostatin and
vascular endothelial growth factor release Li Ma, Susan N. Elliott, Giuseppe Cirino, Andre Buret, Louis J. Ignarro, and John L. Wallace Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6470–6475. Published online 2001 May 15. doi: 10.1073/pnas.111150798.PMCID: PMC33492 Fluid shear stress inhibits TNF-α activation of JNK but not
ERK1/2 or p38 in human umbilical vein endothelial cells: Inhibitory
crosstalk among MAPK family members James Surapisitchat, Ryan J. Hoefen, Xinchun Pi, Masanori Yoshizumi, Chen Yan, and Bradford C. Berk Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6476–6481. Published online 2001 May 15. doi: 10.1073/pnas.101134098.PMCID: PMC33493 Mechanism underlying bupivacaine inhibition of G protein-gated
inwardly rectifying K+ channels Wei Zhou, Christine Arrabit, Senyon Choe, and Paul A. Slesinger Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6482–6487. Published online 2001 May 15. doi: 10.1073/pnas.111447798.PMCID: PMC33494 Physiology Evidence in support of a four
transmembrane-pore-transmembrane topology model for the
Arabidopsis thaliana Na+/K+
translocating AtHKT1 protein, a member of the superfamily of
K+ transporters Yasuhiro Kato, Masao Sakaguchi, Yasuo Mori, Kumiko Saito, Tatsunosuke Nakamura, Evert P. Bakker, Yoko Sato, Shinobu Goshima, and Nobuyuki Uozumi Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6488–6493. Published online 2001 May 8. doi: 10.1073/pnas.101556598.PMCID: PMC33495 Perilipin ablation results in a lean mouse with aberrant
adipocyte lipolysis, enhanced leptin production, and resistance
to diet-induced obesity J. T. Tansey, C. Sztalryd, J. Gruia-Gray, D. L. Roush, J. V. Zee, O. Gavrilova, M. L. Reitman, C.-X. Deng, C. Li, A. R. Kimmel, and C. Londos Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6494–6499. doi: 10.1073/pnas.101042998.PMCID: PMC33496 Cloning and characterization of FGF23 as a causative factor of
tumor-induced osteomalacia Takashi Shimada, Satoru Mizutani, Takanori Muto, Takashi Yoneya, Rieko Hino, Shu Takeda, Yasuhiro Takeuchi, Toshiro Fujita, Seiji Fukumoto, and Takeyoshi Yamashita Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6500–6505. Published online 2001 May 8. doi: 10.1073/pnas.101545198.PMCID: PMC33497 Plant Biology Sense- and antisense-mediated gene silencing in tobacco is
inhibited by the same viral suppressors and is associated with accumulation of small RNAs Francesco Di Serio, Hanspeter Schöb, Alejandro Iglesias, Corina Tarina, Estelle Bouldoires, and Frederick Meins, Jr. Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6506–6510. Published online 2001 May 15. doi: 10.1073/pnas.111423098.PMCID: PMC33498 Tomato Ve disease resistance genes encode cell
surface-like receptors Lawrence M. Kawchuk, John Hachey, Dermot R. Lynch, Frank Kulcsar, Gijs van Rooijen, Doug R. Waterer, Albert Robertson, Eric Kokko, Robert Byers, Ronald J. Howard, Rainer Fischer, and Dirk Prüfer Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6511–6515. Published online 2001 May 1. doi: 10.1073/pnas.091114198.PMCID: PMC33499 An important role of an inducible RNA-dependent RNA polymerase in
plant antiviral defense Zhixin Xie, Baofang Fan, Chunhong Chen, and Zhixiang Chen Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6516–6521. Published online 2001 May 15. doi: 10.1073/pnas.111440998.PMCID: PMC33500 Induction of male sterility in plants by metabolic engineering of
the carbohydrate supply Marc Goetz, Dietmute E. Godt, Anne Guivarc'h, Uwe Kahmann, Dominique Chriqui, and Thomas Roitsch Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6522–6527. doi: 10.1073/pnas.091097998.PMCID: PMC33501 Social Sciences Anthropology Stable isotope evidence for increasing dietary breadth in
the European mid-Upper Paleolithic Michael P. Richards, Paul B. Pettitt, Mary C. Stiner, and Erik Trinkaus Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6528–6532. doi: 10.1073/pnas.111155298.PMCID: PMC33502 Social Sciences From the Cover: Changes in the prevalence of chronic disability in the United
States black and nonblack population above age 65 from 1982 to 1999 Kenneth G. Manton and XiLiang Gu Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6354–6359. Published online 2001 May 8. doi: 10.1073/pnas.111152298.PMCID: PMC33472 Correction Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6533. Published online 2001 May 15. PMCID: PMC55959 Corrects: William C. Nierman, et al. Complete genome sequence of
Caulobacter crescentus. Proc Natl Acad Sci U S A. 2001 March 27; 98(7): 4136–4141. |