| | This journal provides immediate access to some articles. Colloquium Papers The biotic crisis and the future of evolution Norman Myers and Andrew H. Knoll PMCID: PMC33223 Lessons from the past: Evolutionary impacts of mass extinctions David Jablonski PMCID: PMC33224 Lessons from the past: Biotic recoveries from mass extinctions Douglas H. Erwin PMCID: PMC33225 Loss of speciation rate will impoverish future diversity Michael L. Rosenzweig PMCID: PMC33226 What was natural in the coastal oceans? Jeremy B. C. Jackson PMCID: PMC33227 The future of coral reefs Nancy Knowlton PMCID: PMC33228 Disrupting evolutionary processes: The effect of habitat
fragmentation on collared lizards in the Missouri Ozarks Alan R. Templeton, Robert J. Robertson, Jennifer Brisson, and Jared Strasburg PMCID: PMC33229 Human-caused environmental change: Impacts on plant diversity and
evolution David Tilman and Clarence Lehman PMCID: PMC33230 Plant biology in the future F. A. Bazzaz PMCID: PMC33231 The evolutionary impact of invasive species H. A. Mooney and E. E. Cleland PMCID: PMC33232 Rapid plant diversification: Planning for an evolutionary future R. M. Cowling and R. L. Pressey PMCID: PMC33233 Human-modified ecosystems and future evolution David Western PMCID: PMC33234 The current biodiversity extinction event: Scenarios for
mitigation and recovery Michael J. Novacek and Elsa E. Cleland PMCID: PMC33235 Declines of biomes and biotas and the future of evolution David S. Woodruff PMCID: PMC33236 Intervening in evolution: Ethics and actions Paul R. Ehrlich PMCID: PMC33237 From the Academy New Members and Foreign Associates Elected to the National
Academy of Sciences on May 1, 2001: 72 New Members Chosen by the Academy PMCID: PMC33222 Commentaries A fluid connection: Cholesterol and Aβ Benjamin Wolozin PMCID: PMC33340 Neocentromeres and human artificial chromosomes: An unnatural act Huntington F. Willard PMCID: PMC33217 Notch signaling during vascular development Thomas Gridley PMCID: PMC33218 Don't stop for repairs in a war zone: Darwinian evolution unites
genes and environment in cancer development Jarle Breivik PMCID: PMC33219 Livestock genetic origins: Goats buck the trend David E. MacHugh and Daniel G. Bradley PMCID: PMC33220 When developmental biology meets human pathology G. Karsenty PMCID: PMC33221 Physical Sciences Chemistry Molecular dynamics of a grid-mounted molecular dipolar rotor in a
rotating electric field Jaroslav Vacek and Josef Michl PMCID: PMC33238 Non-Arrhenius kinetics for the loop closure of a DNA hairpin Mark I. Wallace, Liming Ying, Shankar Balasubramanian, and David Klenerman PMCID: PMC33256 Geology Selective adsorption of l- and d-amino
acids on calcite: Implications for biochemical homochirality Robert M. Hazen, Timothy R. Filley, and Glenn A. Goodfriend PMCID: PMC33239 Statistics Statistical modeling of large microarray data sets to identify
stimulus-response profiles Lue Ping Zhao, Ross Prentice, and Linda Breeden PMCID: PMC33264 Biological Sciences Biochemistry Crystal structures of the vitamin D receptor complexed to
superagonist 20-epi ligands G. Tocchini-Valentini, N. Rochel, J. M. Wurtz, A. Mitschler, and D. Moras PMCID: PMC33240 Protein quantification from complex protein mixtures using a
proteomics methodology with single-cell resolution Hong-Tao Zhang, Janet E. Kacharmina, Kevin Miyashiro, Mark I. Greene, and James Eberwine PMCID: PMC33241 Dissection of the ion-induced folding of the hammerhead ribozyme
using 19F NMR Christian Hammann, David G. Norman, and David M. J. Lilley PMCID: PMC33242 Structure of Hjc, a Holliday junction resolvase, from
Sulfolobus solfataricus Charles S. Bond, Mamuka Kvaratskhelia, Derek Richard, Malcolm F. White, and William N. Hunter PMCID: PMC33243 Structure of melanoma inhibitory activity protein, a member
of a recently identified family of secreted proteins Julie C. Lougheed, James M. Holton, Tom Alber, J. Fernando Bazan, and Tracy M. Handel PMCID: PMC33244 The chaperone GroEL is required for the final assembly of the
molybdenum-iron protein of nitrogenase Markus W. Ribbe and Barbara K. Burgess PMCID: PMC33245 The role of distinct p185neu extracellular subdomains
for dimerization with the epidermal growth factor (EGF) receptor and
EGF-mediated signaling Toru Kumagai, James G. Davis, Takeo Horie, Donald M. O'Rourke, and Mark I. Greene PMCID: PMC33246 The crystal structure of a heptameric archaeal Sm protein:
Implications for the eukaryotic snRNP core Cameron Mura, Duilio Cascio, Michael R. Sawaya, and David S. Eisenberg PMCID: PMC33247 Homologous-pairing activity of the human DNA-repair
proteins Xrcc3 ![[center dot]](corehtml/pmc/pmcents/middot.gif) Rad51C Hitoshi Kurumizaka, Shukuko Ikawa, Maki Nakada, Keiko Eda, Wataru Kagawa, Minoru Takata, Shunichi Takeda, Shigeyuki Yokoyama, and Takehiko Shibata PMCID: PMC33248 TFIIH action in transcription initiation and promoter escape
requires distinct regions of downstream promoter DNA Lori Spangler, Xiaoxue Wang, Joan W. Conaway, Ronald C. Conaway, and Arik Dvir PMCID: PMC33249 Hydrogen peroxide mediates the cell growth and transformation
caused by the mitogenic oxidase Nox1 Rebecca S. Arnold, Jing Shi, Emma Murad, Anne M. Whalen, Carrie Q. Sun, Rathnagiri Polavarapu, Sampath Parthasarathy, John A. Petros, and J. David Lambeth PMCID: PMC33250 Differential fluorescence labeling of cysteinyl clusters uncovers
high tissue levels of thionein Yi Yang, Wolfgang Maret, and Bert L. Vallee PMCID: PMC33251 Methionine adenosyltransferase 1A knockout mice are predisposed
to liver injury and exhibit increased expression of genes involved
in proliferation Shelly C. Lu, Luis Alvarez, Zong-Zhi Huang, Lixin Chen, Wei An, Fernando J. Corrales, Matías A. Avila, Gary Kanel, and José M. Mato PMCID: PMC33252 Evaluating the binding selectivity of transthyretin amyloid
fibril inhibitors in blood plasma Hans E. Purkey, Michael I. Dorrell, and Jeffery W. Kelly PMCID: PMC33253 Biophysics RNA–protein hybrid ribozymes that efficiently cleave any mRNA
independently of the structure of the target RNA Masaki Warashina, Tomoko Kuwabara, Yoshio Kato, Masayuki Sano, and Kazunari Taira PMCID: PMC33254 Tryptophan zippers: Stable, monomeric β-hairpins Andrea G. Cochran, Nicholas J. Skelton, and Melissa A. Starovasnik PMCID: PMC33255 Non-Arrhenius kinetics for the loop closure of a DNA hairpin Mark I. Wallace, Liming Ying, Shankar Balasubramanian, and David Klenerman PMCID: PMC33256 Comparison of the early stages of forced unfolding for
fibronectin type III modules David Craig, André Krammer, Klaus Schulten, and Viola Vogel PMCID: PMC33257 Three-dimensional domain swapping in p13suc1 occurs in the
unfolded state and is controlled by conserved proline residues F. Rousseau, J. W. H. Schymkowitz, H. R. Wilkinson, and L. S. Itzhaki PMCID: PMC33258 Cell Biology Ubc9 interacts with a nuclear localization signal and mediates
nuclear localization of the paired-like homeobox protein Vsx-1
independent of SUMO-1 modification Aaron L. Kurtzman and Nisson Schechter PMCID: PMC33259 Proteomic dissection of dome formation in a mammary cell line:
Role of tropomyosin-5b and maspin I. Zucchi, L. Bini, R. Valaperta, A. Ginestra, D. Albani, L. Susani, J. C. Sanchez, S. Liberatori, B. Magi, R. Raggiaschi, D. F. Hochstrasser, V. Pallini, P. Vezzoni, and R. Dulbecco PMCID: PMC33260 Rac and Cdc42 GTPases control hematopoietic stem cell shape,
adhesion, migration, and mobilization F.-C. Yang, S. J. Atkinson, Y. Gu, J. B. Borneo, A. W. Roberts, Y. Zheng, J. Pennington, and D. A. Williams PMCID: PMC33261 SNARE proteins are highly enriched in lipid rafts in PC12 cells:
Implications for the spatial control of exocytosis Luke H. Chamberlain, Robert D. Burgoyne, and Gwyn W. Gould PMCID: PMC33262 Rck2, a member of the calmodulin-protein kinase
family, links protein synthesis to high osmolarity MAP kinase
signaling in budding yeast Markus Teige, Elisabeth Scheikl, Vladimir Reiser, Helmut Ruis, and Gustav Ammerer PMCID: PMC33263 Statistical modeling of large microarray data sets to identify
stimulus-response profiles Lue Ping Zhao, Ross Prentice, and Linda Breeden PMCID: PMC33264 Developmental Biology From the Cover:
neuralized is essential for a subset of Notch
pathway-dependent cell fate decisions during
Drosophila eye development Eric C. Lai and Gerald M. Rubin PMCID: PMC33265 Vascular patterning defects associated with expression of
activated Notch4 in embryonic endothelium H. Uyttendaele, J. Ho, J. Rossant, and J. Kitajewski PMCID: PMC33266 Changes in global gene expression patterns during development and
maturation of the rat kidney Robert O. Stuart, Kevin T. Bush, and Sanjay K. Nigam PMCID: PMC33267 Ecology Ecosystem impacts of three sequential hurricanes (Dennis, Floyd,
and Irene) on the United States' largest lagoonal estuary, Pamlico
Sound, NC Hans W. Paerl, Jerad D. Bales, Larry W. Ausley, Christopher P. Buzzelli, Larry B. Crowder, Lisa A. Eby, John M. Fear, Malia Go, Benjamin L. Peierls, Tammi L. Richardson, and Joseph S. Ramus PMCID: PMC33268 Geometric constraints explain much of the species richness
pattern in African birds Walter Jetz and Carsten Rahbek PMCID: PMC33269 Population maintenance among tropical reef fishes: Inferences
from small-island endemics D. Ross Robertson PMCID: PMC33270 Evolution Evolution of vertebrate steroid receptors from an ancestral
estrogen receptor by ligand exploitation and serial genome expansions Joseph W. Thornton PMCID: PMC33271 Y chromosome polymorphism is a strong determinant of male fitness
in Drosophila melanogaster Adam K. Chippindale and William R. Rice PMCID: PMC33272 Traumatic insemination and sexual conflict in the bed bug
Cimex lectularius Alastair D. Stutt and Michael T. Siva-Jothy PMCID: PMC33273 Does recombination improve selection on codon usage? Lessons from
nematode and fly complete genomes Gabriel Marais, Dominique Mouchiroud, and Laurent Duret PMCID: PMC33274 Trans-spliced leader addition to mRNAs in a cnidarian Nicholas A. Stover and Robert E. Steele PMCID: PMC33275 A power law for cells Ricardo B. R. Azevedo and Armand M. Leroi PMCID: PMC33276 Genetics From the Cover:
Construction of neocentromere-based human minichromosomes by
telomere-associated chromosomal truncation Richard Saffery, Lee H. Wong, Danielle V. Irvine, Melissa A. Bateman, Belinda Griffiths, Suzanne M. Cutts, Michael R. Cancilla, Angela C. Cendron, Angela J. Stafford, and K. H. Andy Choo PMCID: PMC33277 Comprehensive copy number and gene expression profiling of the
17q23 amplicon in human breast cancer Outi Monni, Maarit Bärlund, Spyro Mousses, Juha Kononen, Guido Sauter, Mervi Heiskanen, Paulina Paavola, Kristiina Avela, Yidong Chen, Michael L. Bittner, and Anne Kallioniemi PMCID: PMC33278 Mice lacking DNA topoisomerase IIIβ develop to maturity but
show a reduced mean lifespan Kelvin Y. Kwan and James C. Wang PMCID: PMC33279 Sequence conservation at human and mouse orthologous common
fragile regions, FRA3B/FHIT and
Fra14A2/Fhit Takeshi Shiraishi, Teresa Druck, Koshi Mimori, Jacob Flomenberg, Lori Berk, Hansjuerg Alder, Webb Miller, Kay Huebner, and Carlo M. Croce PMCID: PMC33280 The HMG-domain protein BAP111 is important for the function
of the BRM chromatin-remodeling complex
in vivo Ophelia Papoulas, Gary Daubresse, Jennifer A. Armstrong, Janet Jin, Matthew P. Scott, and John W. Tamkun PMCID: PMC33281 Molecular and genealogical evidence for a founder effect in
Fanconi anemia families of the Afrikaner population of South Africa A. J. Tipping, T. Pearson, N. V. Morgan, R. A. Gibson, L. P. Kuyt, C. Havenga, E. Gluckman, H. Joenje, T. de Ravel, S. Jansen, and C. G. Mathew PMCID: PMC33282 Evolutionary relationships among Rel domains indicate functional
diversification by recombination Isabella A. Graef, Julie M. Gastier, Uta Francke, and Gerald R. Crabtree PMCID: PMC33283 Immunology Granzymes A and B directly cleave lamins and disrupt the nuclear
lamina during granule-mediated cytolysis Dong Zhang, Paul J. Beresford, Arnold H. Greenberg, and Judy Lieberman PMCID: PMC33284 Virulence of a Mycobacterium tuberculosis clinical
isolate in mice is determined by failure to induce Th1 type
immunity and is associated with induction of IFN-α/β Claudia Manca, Liana Tsenova, Amy Bergtold, Sherry Freeman, Michael Tovey, James M. Musser, Clifton E. Barry, III, Victoria H. Freedman, and Gilla Kaplan PMCID: PMC33285 Cooperative enhancement of specificity in a lattice of T
cell receptors Cliburn Chan, Andrew J. T. George, and Jaroslav Stark PMCID: PMC33286 Surface expression and function of p75/AIRM-1 or CD33 in acute
myeloid leukemias: Engagement of CD33 induces apoptosis of
leukemic cells Chiara Vitale, Chiara Romagnani, Antonio Puccetti, Daniel Olive, Regis Costello, Laura Chiossone, Anna Pitto, Andrea Bacigalupo, Lorenzo Moretta, and Maria Cristina Mingari PMCID: PMC33287 Medical Sciences From the Cover:
Carcinogen-specific induction of genetic instability Alberto Bardelli, Daniel P. Cahill, Gabi Lederer, Michael R. Speicher, Kenneth W. Kinzler, Bert Vogelstein, and Christoph Lengauer PMCID: PMC33288 Involvement of a human gene related to the Drosophila
spen gene in the recurrent t(1;22) translocation of acute
megakaryocytic leukemia Thomas Mercher, Maryvonne Busson-Le Coniat, Richard Monni, Martine Mauchauffé, Florence Nguyen Khac, Lætitia Gressin, Francine Mugneret, Thierry Leblanc, Nicole Dastugue, Roland Berger, and Olivier A. Bernard PMCID: PMC33289 A cardiac myocyte vascular endothelial growth factor paracrine
pathway is required to maintain cardiac function Frank J. Giordano, Hans-Peter Gerber, Simon-Peter Williams, Nicholas VanBruggen, Stuart Bunting, Pilar Ruiz-Lozano, Yusu Gu, Anjali K. Nath, Yan Huang, Reed Hickey, Nancy Dalton, Kirk L. Peterson, John Ross, Jr., Kenneth R. Chien, and Napoleone Ferrara PMCID: PMC33290 Proteinase inhibitors I and II from potatoes block UVB-induced
AP-1 activity by regulating the AP-1 protein compositional patterns
in JB6 cells Guangming Liu, Nanyue Chen, Akira Kaji, Ann M. Bode, Clarence A. Ryan, and Zigang Dong PMCID: PMC33291 S-nitrosothiol repletion by an inhaled gas
regulates pulmonary function Martin P. Moya, Andrew J. Gow, Timothy J. McMahon, Eric J. Toone, Ira M. Cheifetz, Ronald N. Goldberg, and Jonathan S. Stamler PMCID: PMC33292 Linking osteopetrosis and pycnodysostosis: Regulation of
cathepsin K expression by the microphthalmia transcription factor
family G. Motyckova, K. N. Weilbaecher, M. Horstmann, D. J. Rieman, D. Z. Fisher, and D. E. Fisher PMCID: PMC33293 Low IGF-I suppresses VEGF-survival signaling in retinal
endothelial cells: Direct correlation with clinical retinopathy
of prematurity Ann Hellstrom, Carole Perruzzi, Meihua Ju, Eva Engström, Anna-Lena Hård, Jun-Li Liu, Kerstin Albertsson-Wikland, Björn Carlsson, Aimon Niklasson, Lena Sjödell, Derek LeRoith, Donald R. Senger, and Lois E. H. Smith PMCID: PMC33294 Cardiac βARK1 inhibition prolongs survival and augments β
blocker therapy in a mouse model of severe heart failure Victoria B. Harding, Larry R. Jones, Robert J. Lefkowitz, Walter J. Koch, and Howard A. Rockman PMCID: PMC33295 From the Cover:
Low cholesterol stimulates the nonamyloidogenic pathway by its
effect on the α-secretase ADAM 10 Elzbieta Kojro, Gerald Gimpl, Sven Lammich, Winfried März, and Falk Fahrenholz PMCID: PMC33296 Avicins: Triterpenoid saponins from Acacia
victoriae (Bentham) induce apoptosis
by mitochondrial perturbation Valsala Haridas, Masahiro Higuchi, Gamini S. Jayatilake, David Bailey, Kalpana Mujoo, Mary E. Blake, Charles J. Arntzen, and Jordan U. Gutterman PMCID: PMC33297 Nonlinear-dynamical arrhythmia control in humans David J. Christini, Kenneth M. Stein, Steven M. Markowitz, Suneet Mittal, David J. Slotwiner, Marc A. Scheiner, Sei Iwai, and Bruce B. Lerman PMCID: PMC33298 Microbiology Large carbon isotope fractionation associated with oxidation
of methyl halides by methylotrophic bacteria L. G. Miller, R. M. Kalin, S. E. McCauley, J. T. G. Hamilton, D. B. Harper, D. B. Millet, R. S. Oremland, and A. H. Goldstein PMCID: PMC33299 The P450–1 gene of Gibberella
fujikuroi encodes a multifunctional enzyme in
gibberellin biosynthesis María Cecilia Rojas, Peter Hedden, Paul Gaskin, and Bettina Tudzynski PMCID: PMC33300 Regulation of toxin synthesis in Clostridium
difficile by an alternative RNA polymerase sigma factor Nagraj Mani and Bruno Dupuy PMCID: PMC33301 Host microarray analysis reveals a role for the
Salmonella response regulator phoP in
human macrophage cell death Corrella S. Detweiler, Dolores B. Cunanan, and Stanley Falkow PMCID: PMC33302 Neurobiology Simvastatin strongly reduces levels of Alzheimer's disease
β-amyloid peptides Aβ42 and Aβ40 in vitro and
in vivo K. Fassbender, M. Simons, C. Bergmann, M. Stroick, D. Lütjohann, P. Keller, H. Runz, S. Kühl, T. Bertsch, K. von Bergmann, M. Hennerici, K. Beyreuther, and T. Hartmann PMCID: PMC33303 Transferring an inborn auditory perceptual predisposition with
interspecies brain transplants Kevin D. Long, Grace Kennedy, and Evan Balaban PMCID: PMC33304 BMP2-mediated alteration in the developmental pathway of fetal
mouse brain cells from neurogenesis to astrocytogenesis Kinichi Nakashima, Takumi Takizawa, Wataru Ochiai, Makoto Yanagisawa, Tatsuhiro Hisatsune, Masato Nakafuku, Kohei Miyazono, Tadamitsu Kishimoto, Ryoichiro Kageyama, and Tetsuya Taga PMCID: PMC33305 FGF-2 regulation of neurogenesis in adult hippocampus after
brain injury Shinichi Yoshimura, Yasushi Takagi, Jun Harada, Tetsuyuki Teramoto, Sunu S. Thomas, Christian Waeber, Joanna C. Bakowska, Xandra O. Breakefield, and Michael A. Moskowitz PMCID: PMC33306 Growth factors regulate phototransduction in retinal rods by
modulating cyclic nucleotide-gated channels through
dephosphorylation of a specific tyrosine residue Alexei Savchenko, Timothy W. Kraft, Elena Molokanova, and Richard H. Kramer PMCID: PMC33307 Pharmacology Growth factor treatment enhances vestibular hair cell renewal and
results in improved vestibular function Richard D. Kopke, Ronald L. Jackson, Geming Li, Mark D. Rasmussen, Michael E. Hoffer, Dorothy A. Frenz, Michael Costello, Peter Schultheiss, and Thomas R. Van de Water PMCID: PMC33308 Physiology Excitation–contraction coupling is unaffected
by drastic alteration of the sequence surrounding residues
L720–L764 of the α1S II-III loop Christina M. Wilkens, Nicole Kasielke, Bernhard E. Flucher, Kurt G. Beam, and Manfred Grabner PMCID: PMC33309 Phenotypic consequences of lung-specific inducible expression
of FGF-3 Bihong Zhao, Steven S. Chua, Mark M. Burcin, Susan D. Reynolds, Barry R. Stripp, Robert A. Edwards, Milton J. Finegold, Sophia Y. Tsai, and Francesco J. DeMayo PMCID: PMC33310 Radial and longitudinal diffusion of myoglobin in single living
heart and skeletal muscle cells Simon Papadopoulos, Volker Endeward, Brigitta Revesz-Walker, Klaus D. Jürgens, and Gerolf Gros PMCID: PMC33311 Plant Biology Two enzymes of
diacylglyceryl-O-4′-(N,N,N,-trimethyl)homoserine
biosynthesis are encoded by btaA and
btaB in the purple bacterium Rhodobacter
sphaeroides Rouven M. Klug and Christoph Benning PMCID: PMC33312 BRS1, a serine carboxypeptidase, regulates BRI1 signaling in
Arabidopsis thaliana Jia Li, Kevin A. Lease, Frans E. Tax, and John C. Walker PMCID: PMC33313 A maize cytokinin gene encoding an O-glucosyltransferase specific to cis-zeatin Ruth C. Martin, Machteld C. Mok, Jeffrey E. Habben, and David W. S. Mok PMCID: PMC33314 Population Biology From the Cover:
Multiple maternal origins and weak phylogeographic structure in
domestic goats Gordon Luikart, Ludovic Gielly, Laurent Excoffier, Jean-Denis Vigne, Jean Bouvet, and Pierre Taberlet PMCID: PMC33315 Psychology A neural correlate of syntactic encoding during
speech production Peter Indefrey, Colin M. Brown, Frauke Hellwig, Katrin Amunts, Hans Herzog, Rüdiger J. Seitz, and Peter Hagoort PMCID: PMC33316 Mirror self-recognition in the bottlenose dolphin: A case of
cognitive convergence Diana Reiss and Lori Marino PMCID: PMC33317 Retraction Retraction Tatsumi Arichi, Takafumi Saito, Marian E. Major, Igor M. Belyakov, Mutsunori Shirai, Victor H. Engelhard, Stephen M. Feinstone , and Jay A. Berzofsky PMCID: PMC55904 Retracts: Tatsumi Arichi, et al. Prophylactic DNA vaccine for hepatitis C virus (HCV) infection: HCV-specific cytotoxic T lymphocyte induction and protection from HCV-recombinant vaccinia infection in an HLA-A2.1 transgenic mouse model. Proc Natl Acad Sci U S A. 2000 January 4; 97(1): 297–302. |
