| | This journal provides immediate access to some articles. Commentary Water and proteins: A love–hate relationship Yaakov Levy and José N. Onuchic PMCID: PMC373459 Biographies INAUGURAL ARTICLE by a Recently Elected Academy Member: Biography of Lewis C. Cantley David Bradley PMCID: PMC373460 INAUGURAL ARTICLE by a Recently Elected Academy Member: Biography of Stephen J. Elledge Christen Brownlee PMCID: PMC373462 Physical Sciences Applied Physical Sciences Scanning electron microscopy of cells and tissues under fully hydrated conditions Stephan Thiberge, Amotz Nechushtan, David Sprinzak, Opher Gileadi, Vered Behar, Ory Zik, Yehuda Chowers, Shulamit Michaeli, Joseph Schlessinger, and Elisha Moses PMCID: PMC376183 Chemistry From the Cover:
Water in protein structure prediction Garegin A. Papoian, Johan Ulander, Michael P. Eastwood, Zaida Luthey-Schulten, and Peter G. Wolynes PMCID: PMC373465 Molecular mechanism of enantioselective proton transfer to carbon in catalytic antibody 14D9 Lei Zheng, Ulrich Baumann, and Jean-Louis Reymond PMCID: PMC376184 Physics Biological glass fibers: Correlation between optical and structural properties Joanna Aizenberg, Vikram C. Sundar, Andrew D. Yablon, James C. Weaver, and Gang Chen PMCID: PMC373466 Biological Sciences Applied Biological Sciences Scanning electron microscopy of cells and tissues under fully hydrated conditions Stephan Thiberge, Amotz Nechushtan, David Sprinzak, Opher Gileadi, Vered Behar, Ory Zik, Yehuda Chowers, Shulamit Michaeli, Joseph Schlessinger, and Elisha Moses PMCID: PMC376183 Biochemistry The molecular structure and catalytic mechanism of a novel carboxyl peptidase from Scytalidium lignicolum Masao Fujinaga, Maia M. Cherney, Hiroshi Oyama, Kohei Oda, and Michael N. G. James PMCID: PMC373467 Site-specific Srb10-dependent phosphorylation of the yeast Mediator subunit Med2 regulates gene expression from the 2-μm plasmid Magnus Hallberg, Gennady V. Polozkov, Guo-Zhen Hu, Jenny Beve, Claes M. Gustafsson, Hans Ronne, and Stefan Björklund PMCID: PMC373468 The specificity of SNARE-dependent fusion is encoded in the SNARE motif Fabienne Paumet, Vahid Rahimian, and James E. Rothman PMCID: PMC373469 Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid Jung H. Suh, Swapna V. Shenvi, Brian M. Dixon, Honglei Liu, Anil K. Jaiswal, Rui-Ming Liu, and Tory M. Hagen PMCID: PMC373470 Molecular mechanism of enantioselective proton transfer to carbon in catalytic antibody 14D9 Lei Zheng, Ulrich Baumann, and Jean-Louis Reymond PMCID: PMC376184 The role of the allosteric B site in the fumarase reaction Irwin A. Rose and Todd M. Weaver PMCID: PMC373472 Transcription-induced barriers to supercoil diffusion in the Salmonella typhimurium chromosome Shuang Deng, Richard A. Stein, and N. Patrick Higgins PMCID: PMC373473 Biosynthesis in vitro of Caenorhabditis elegans phosphorylcholine oligosaccharides John F. Cipollo, Antoine Awad, Catherine E. Costello, Phillips W. Robbins, and Carlos B. Hirschberg PMCID: PMC373474 Biophysics Differential dynamics in the G protein-coupled receptor rhodopsin revealed by solution NMR Judith Klein-Seetharaman, Naveena V. K. Yanamala, Fathima Javeed, Philip J. Reeves, Elena V. Getmanova, Michele C. Loewen, Harald Schwalbe, and H. Gobind Khorana PMCID: PMC373475 Solution structure of dengue virus capsid protein reveals another fold Lixin Ma, Christopher T. Jones, Teresa D. Groesch, Richard J. Kuhn, and Carol Beth Post PMCID: PMC373476 Microscopic observations reveal that fusogenic peptides induce liposome shrinkage prior to membrane fusion Fumimasa Nomura, Takehiko Inaba, Satoshi Ishikawa, Miki Nagata, Sho Takahashi, Hirokazu Hotani, and Kingo Takiguchi PMCID: PMC373477 Low-energy circular dichroism of 2-aminopurine dinucleotide as a probe of local conformation of DNA and RNA Neil P. Johnson, Walter A. Baase, and Peter H. von Hippel PMCID: PMC373478 Integrating folding kinetics and protein function: Biphasic kinetics and dual binding specificity in a WW domain John Karanicolas and Charles L. Brooks, III PMCID: PMC373479 Cell Biology INAUGURAL ARTICLE by a Recently Elected Academy Member: The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress Reuben J. Shaw, Monica Kosmatka, Nabeel Bardeesy, Rebecca L. Hurley, Lee A. Witters, Ronald A. DePinho, and Lewis C. Cantley PMCID: PMC373461 Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is required for induction of autophagy during lumen formation in vitro Kenna R. Mills, Mauricio Reginato, Jayanta Debnath, Bridget Queenan, and Joan S. Brugge PMCID: PMC373480 Kinesin's second step Lisa M. Klumpp, Andreas Hoenger, and Susan P. Gilbert PMCID: PMC373481 Annexin 2–caveolin 1 complex is a target of ezetimibe and regulates intestinal cholesterol transport Eric J. Smart, Robert A. De Rose, and Steven A. Farber PMCID: PMC373482 Identification of p53 regulators by genome-wide functional analysis Qihong Huang, Angel Raya, Paul DeJesus, Sheng-Hao Chao, Kim C. Quon, Jeremy S. Caldwell, Sumit K. Chanda, Juan C. Izpisua-Belmonte, and Peter G. Schultz PMCID: PMC373483 Attractant binding alters arrangement of chemoreceptor dimers within its cluster at a cell pole Motohiro Homma, Daisuke Shiomi, Michio Homma, and Ikuro Kawagishi PMCID: PMC373484 Basonuclin 2: An extremely conserved homolog of the zinc finger protein basonuclin Amandine Vanhoutteghem and Philippe Djian PMCID: PMC373485 Developmental Biology INAUGURAL ARTICLE by a Recently Elected Academy Member: From the Cover: Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein Michael T. Tetzlaff, Wei Yu, Mamie Li, Pumin Zhang, Milton Finegold, Kathleen Mahon, J. Wade Harper, Robert J. Schwartz, and Stephen J. Elledge PMCID: PMC373463 Hearing loss and retarded cochlear development in mice lacking type 2 iodothyronine deiodinase Lily Ng, Richard J. Goodyear, Chad A. Woods, Mark J. Schneider, Edward Diamond, Guy P. Richardson, Matthew W. Kelley, Donald L. St. Germain, Valerie Anne Galton, and Douglas Forrest PMCID: PMC373486 Evolution Codon usage between genomes is constrained by genome-wide mutational processes Swaine L. Chen, William Lee, Alison K. Hottes, Lucy Shapiro, and Harley H. McAdams PMCID: PMC373487 Decreased expression of Cu–Zn superoxide dismutase 1 in ants with extreme lifespan Joel D. Parker, Karen M. Parker, Barbara H. Sohal, Rajindar S. Sohal, and Laurent Keller PMCID: PMC373488 High MHC diversity maintained by balancing selection in an otherwise genetically monomorphic mammal Andres Aguilar, Gary Roemer, Sally Debenham, Matthew Binns, David Garcelon, and Robert K. Wayne PMCID: PMC373489 Transmembrane protein domains rarely use covalent domain recombination as an evolutionary mechanism Yang Liu, Mark Gerstein, and Donald M. Engelman PMCID: PMC373490 Genetics Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset The U.S.–Venezuela Collaborative Research Project and Nancy S. Wexler PMCID: PMC373491 A variable dinucleotide repeat in the CFTR gene contributes to phenotype diversity by forming RNA secondary structures that alter splicing Timothy W. Hefferon, Joshua D. Groman, Catherine E. Yurk, and Garry R. Cutting PMCID: PMC373492 Siah-1b is a direct transcriptional target of p53: Identification of the functional p53 responsive element in the siah-1b promoter Giusy Fiucci, Séverine Beaucourt, Dominique Duflaut, Alexandra Lespagnol, Pamela Stumptner-Cuvelette, Anne Géant, Gilles Buchwalter, Marcel Tuynder, Laurent Susini, Jean-Michel Lassalle, Christine Wasylyk, Bohdan Wasylyk, Moshe Oren, Robert Amson, and Adam Telerman PMCID: PMC373493 Immunology Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection Koichi Tabeta, Philippe Georgel, Edith Janssen, Xin Du, Kasper Hoebe, Karine Crozat, Suzanne Mudd, Louis Shamel, Sosathya Sovath, Jason Goode, Lena Alexopoulou, Richard A. Flavell, and Bruce Beutler PMCID: PMC373494 Intestinal inflammation in mice deficient in Tir8, an inhibitory member of the IL-1 receptor family Cecilia Garlanda, Federica Riva, Nadia Polentarutti, Chiara Buracchi, Marina Sironi, Maida De Bortoli, Marta Muzio, Raffaella Bergottini, Eugenio Scanziani, Annunciata Vecchi, Emilio Hirsch, and Alberto Mantovani PMCID: PMC373495 Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors James R. Carlyle, Amanda M. Jamieson, Stephan Gasser, Christopher S. Clingan, Hisashi Arase, and David H. Raulet PMCID: PMC373496 Toll-like receptor 3-mediated activation of NF-κB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-β Zhengfan Jiang, Tak W. Mak, Ganes Sen, and Xiaoxia Li PMCID: PMC373497 Structural mechanism for affinity maturation of an anti-lysozyme antibody Ana Cauerhff, Fernando A. Goldbaum, and Bradford C. Braden PMCID: PMC373498 Differential tumor necrosis factor receptor 2-mediated editing of virus-specific CD8+ effector T cells Stephen J. Turner, Nicole L. La Gruta, John Stambas, Gabriela Diaz, and Peter C. Doherty PMCID: PMC373499 Structural availability influences the capacity of autoantigenic epitopes to induce a widespread lupus-like autoimmune response Micah T. McClain, Carol S. Lutz, Kenneth M. Kaufman, Ofer Z. Faig, Timothy F. Gross, and Judith A. James PMCID: PMC373500 Medical Sciences Human CD34+ cells differentiate into microglia and express recombinant therapeutic protein Muriel Asheuer, Françoise Pflumio, Sonia Benhamida, Anne Dubart-Kupperschmitt, Françoise Fouquet, Yoshinori Imai, Patrick Aubourg, and Nathalie Cartier PMCID: PMC373501 Synergistic activation of NF-κB by nontypeable Haemophilus influenzae and tumor necrosis factor α Takahiro Watanabe, Hirofumi Jono, Jiahuai Han, David J. Lim, and Jian-Dong Li PMCID: PMC373502 Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney Tsuyoshi Mikkaichi, Takehiro Suzuki, Tohru Onogawa, Masayuki Tanemoto, Hiroya Mizutamari, Masahiro Okada, Tatsuji Chaki, Satohiro Masuda, Taro Tokui, Nobuaki Eto, Michiaki Abe, Fumitoshi Satoh, Michiaki Unno, Takanori Hishinuma, Ken-ichi Inui, Sadayoshi Ito, Junichi Goto, and Takaaki Abe PMCID: PMC373503 Specific mutations of hepatitis B virus in plasma predict liver cancer development Shuang-Yuan Kuang, Peta E. Jackson, Jin-Bing Wang, Pei-Xing Lu, Alvaro Muñoz, Geng-Sun Qian, Thomas W. Kensler, and John D. Groopman PMCID: PMC373504 Systemic delivery of human microdystrophin to regenerating mouse dystrophic muscle by muscle progenitor cells Estanislao Bachrach, Sheng Li, Antonio L. Perez, Jaclyn Schienda, Kalliopi Liadaki, Jay Volinski, Alan Flint, Jeffrey Chamberlain, and Louis M. Kunkel PMCID: PMC373505 From the Cover:
Inactivation of a Pseudomonas aeruginosa quorum-sensing signal by human airway epithelia Carlene K. Chun, Egon A. Ozer, Michael J. Welsh, Joseph Zabner, and E. P. Greenberg PMCID: PMC373506 Microbiology CbiZ, an amidohydrolase enzyme required for salvaging the coenzyme B12 precursor cobinamide in archaea Jesse D. Woodson and Jorge C. Escalante-Semerena PMCID: PMC373507 Dissecting virulence: Systematic and functional analyses of a pathogenicity island Wanyin Deng, José L. Puente, Samantha Gruenheid, Yuling Li, Bruce A. Vallance, Alejandra Vázquez, Jeannette Barba, J. Antonio Ibarra, Paul O'Donnell, Pavel Metalnikov, Keith Ashman, Sansan Lee, David Goode, Tony Pawson, and B. Brett Finlay PMCID: PMC373508 The herpes simplex virus 1 UL41 gene-dependent destabilization of cellular RNAs is selective and may be sequence-specific Audrey Esclatine, Brunella Taddeo, Linton Evans, and Bernard Roizman PMCID: PMC373509 Neuroscience Presynaptic homeostasis at CNS nerve terminals compensates for lack of a key Ca2+ entry pathway Erika S. Piedras-Rentería, Jason L. Pyle, Max Diehn, Lindsey L. Glickfeld, Nobutoshi C. Harata, Yuqing Cao, Ege T. Kavalali, Patrick O. Brown, and Richard W. Tsien PMCID: PMC373510 Frontostriatal deficits in fragile X syndrome: Relation to FMR1 gene expression V. Menon, J. Leroux, C. D. White, and A. L. Reiss PMCID: PMC373511 Overexpression of acid-sensing ion channel 1a in transgenic mice increases acquired fear-related behavior John A. Wemmie, Matthew W. Coryell, Candice C. Askwith, Ejvis Lamani, A. Soren Leonard, Curt D. Sigmund, and Michael J. Welsh PMCID: PMC373512 Inhibition of neuronal phenotype by PTEN in PC12 cells Sergei Musatov, Jill Roberts, Andrew I. Brooks, John Pena, Simone Betchen, Donald W. Pfaff, and Michael G. Kaplitt PMCID: PMC373513 Amyloid β peptide load is correlated with increased β-secretase activity in sporadic Alzheimer's disease patients Rena Li, Kristina Lindholm, Li-Bang Yang, Xu Yue, Martin Citron, Riqiang Yan, Thomas Beach, Lucia Sue, Marwan Sabbagh, Huaibin Cai, Philip Wong, Donald Price, and Yong Shen PMCID: PMC373514 Delay accuracy in bat sonar is related to the reciprocal of normalized echo bandwidth, or Q James A. Simmons, Nicola Neretti, Nathan Intrator, Richard A. Altes, Michael J. Ferragamo, and Mark I. Sanderson PMCID: PMC373515 Transgene-driven expression of the Doppel protein in Purkinje cells causes Purkinje cell degeneration and motor impairment Lucy Anderson, Daniela Rossi, Jackie Linehan, Sebastian Brandner, and Charles Weissmann PMCID: PMC373516 From the Cover:
The tissue plasminogen activator-plasmin system participates in the rewarding effect of morphine by regulating dopamine release Taku Nagai, Kiyofumi Yamada, Masako Yoshimura, Kazuhiro Ishikawa, Yoshiaki Miyamoto, Kazuki Hashimoto, Yukihiro Noda, Atsumi Nitta, and Toshitaka Nabeshima PMCID: PMC373517 The long-term stability of new hippocampal place fields requires new protein synthesis Naveen T. Agnihotri, Robert D. Hawkins, Eric R. Kandel, and Clifford Kentros PMCID: PMC373518 Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by α5 subunit-containing γ-aminobutyric acid type A receptors Valerie B. Caraiscos, Erin M. Elliott, Kong E. You-Ten, Victor Y. Cheng, Delia Belelli, J. Glen Newell, Michael F. Jackson, Jeremy J. Lambert, Thomas W. Rosahl, Keith A. Wafford, John F. MacDonald, and Beverley A. Orser PMCID: PMC373519 Pharmacology Expression and activation of the farnesoid X receptor in the vasculature David Bishop-Bailey, Desmond T. Walsh, and Timothy D. Warner PMCID: PMC373520 Modulation of rhythmic brain activity by diazepam: GABAAreceptor subtype and state specificity C. Kopp, U. Rudolph, K. Löw, and I. Tobler PMCID: PMC373521 Peripheral analgesic blockade of hypernociception: Activation of arginine/NO/cGMP/protein kinase G/ATP-sensitive K+ channel pathway Daniela Sachs, Fernando Q. Cunha, and Sérgio H. Ferreira PMCID: PMC373522 Physiology Diethylstilbestrol induces fish oocyte maturation Toshinobu Tokumoto, Mika Tokumoto, Ryo Horiguchi, Katsutoshi Ishikawa, and Yoshitaka Nagahama PMCID: PMC373523 Vitamin C controls the cystic fibrosis transmembrane conductance regulator chloride channel Horst Fischer, Christian Schwarzer, and Beate Illek PMCID: PMC373524 The cardiovascular physiologic actions of urocortin II: Acute effects in murine heart failure Tracy L. Bale, Masahiko Hoshijima, Yusu Gu, Nancy Dalton, Keith R. Anderson, Kuo-Fen Lee, Jean Rivier, Kenneth R. Chien, Wylie W. Vale, and Kirk L. Peterson PMCID: PMC373525 Plant Biology Multiple origins of crassulacean acid metabolism and the epiphytic habit in the Neotropical family Bromeliaceae Darren M. Crayn, Klaus Winter, and J. Andrew C. Smith PMCID: PMC373526 Population Biology Persistent colonization and the spread of antibiotic resistance in nosocomial pathogens: Resistance is a regional problem David L. Smith, Jonathan Dushoff, Eli N. Perencevich, Anthony D. Harris, and Simon A. Levin PMCID: PMC373527 Social Sciences Economic Sciences Geography, biogeography, and why some countries are rich and others are poor Douglas A. Hibbs, Jr. and Ola Olsson PMCID: PMC376185 |
