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- Violence in Schizophrenia Patients More Likely Among Those with Childhood Conduct Problems
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July 2, 2007
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Press Release
Some people with schizophrenia who become violent may do so for reasons unrelated to their current illness, according to a new study analyzing data from the Clinical Antipsychotic Trials for Intervention Effectiveness (CATIE).
- Gene Variants Linked to Suicidal Thoughts in Some Men Starting Antidepressant Treatment
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June 7, 2007
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Science Update
Some men who experience suicidal thoughts and behaviors after they first start taking antidepressant medications may be genetically predisposed to do so, according to the latest results from the NIMH-funded Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study.
- Antipsychotic Medications for Schizophrenia on Equal Footing in Improving Patients’ Thinking Skills
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June 4, 2007
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Science Update
Patients with schizophrenia taking antipsychotic medications experience a small improvement in thinking and reasoning skills (neurocognition), but no one medication appears to be better than the others in improving these skills during the first two crucial months of treatment, according to the latest results from the NIMH-funded Clinical Antipsychotic Trials for Intervention Effectiveness (CATIE).
- In Second Try to Treat Depression, Cognitive Therapy Generally As Effective As Medication
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May 1, 2007
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Science Update
Switching to or adding cognitive therapy (CT) after a first unsuccessful attempt at treating depression with an antidepressant medication is generally as effective as switching to or adding another medication, but remission may take longer to achieve.
- Intensive Psychotherapy More Effective Than Brief Therapy for Treating Bipolar Depression
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April 2, 2007
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Press Release
Patients taking medications to treat bipolar disorder are more likely to get well faster and stay well if they receive intensive psychotherapy, according to results from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD), funded by NIMH.
- Study Sheds Light on Medication Treatment Options for Bipolar Disorder
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March 28, 2007
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Press Release
For depressed people with bipolar disorder who are taking a mood stabilizer, adding an antidepressant medication is no more effective than a placebo (sugar pill), according to results published online on March 28, 2007 in the New England Journal of Medicine.
- HIV Treatment May Help Reduce Severity of Mental Impairment in Children with HIV Infection
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March 7, 2007
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Science Update
During the first few years of life, children born with HIV infection are most susceptible to central nervous system (CNS) disease, and can develop impaired cognitive, language, motor and behavioral functioning.
- New Details in Schizophrenia Treatment Trial Emerge
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March 1, 2007
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Press Release
Two new studies from the Clinical Antipsychotic Trials for Intervention Effectiveness (CATIE) provide more insights into comparing treatment options, and to what extent antipsychotic medications help people with schizophrenia learn social, interpersonal and community living skills.
- Landmark Council Session Spotlights “Real World” Trials
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December 21, 2006
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Science Update
Principal investigators of NIMH's four large-scale clinical trials presented study results and their implications at the National Advisory Mental Health Council meeting on September 15, 2006.
- Older Medication May Be More Cost-Effective for Some Patients with Schizophrenia
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December 1, 2006
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Press Release
A new study analyzing the economic implications of the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) concludes that the older (first generation) antipsychotic medication perphenazine was less expensive and no less effective than the newer (second generation) medications used in the trial during initial treatment, suggesting that older antipsychotics still have a role in treating schizophrenia.
