Summaries & Associations of Study Results
TR-516 2-Methylimidazole
Target Organs and Levels of Evidence
NTP Technical Report Number 516
Produced from Chemtrack Database 06/18/03
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| 2-METHYLIMIDAZOLE 693-98-1 |
05/22/03 | USED IN THE MANUFACTURE OF PHARMACEUTICALS, PHOTOGRAPHIC & PHOTOTHERMOGRAPHIC CHEMICALS, DYES, PIGMENTS, AGRICULTURAL CHEMICALS & RUBBER. USED IN EPOXY RESIN SYSTEMS FOR SEMICONDUCTOR POTTING COMPOUNDS AND SOLDERING MASKS. COMPONENT OF POLYMERS INCLUDING EPOXY RESIN PASTES, ACRYLIC RUBBER-FLUORORUBB | Dosed-Feed MR: 0, 300, 1000, OR 3000 PPM; FR: 0, 1000, 2500, OR 5000 PPM; M: 0, 625, 1250, OR 2500 PPM; 60/SEX/SPECIES/GROUP | Southern Research Institute |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: SOME EVIDENCE | THYROID GLAND: FOLLICULAR CELL ADENOMA OR CARCINOMA 1/48 2/46 1/43 5/50 | |||
| MAY HAVE BEEN RELATED: | LIVER: ADENOMA OR CARCINOMA 0/50 1/50 3/50 3/50 | |||
| NON-NEOPLASTIC LESIONS: | THYROID GLAND: FOLLICULAR CELL HYPERPLASIA | |||
| LIVER: MIXED CELL FOCUS | ||||
| FR: CLEAR EVIDENCE | THYROID GLAND: FOLLICULAR CELL ADENOMA 0/49 0/48 0/42 5/48 FOLLICULAR CELL CARCINOMA 1/49 1/48 1/42 7/48 COMBINED 1/49 1/48 1/42 11/48 | |||
| MAY HAVE BEEN RELATED: | LIVER: ADENOMA 1/50 0/49 2/50 4/50 | |||
| NON-NEOPLASTIC LESIONS: | THYROID GLAND: FOLLICULAR CELL HYPERPLASIA | |||
| LIVER: BILE DUCT HYPERPLASIA; GRANULOMATOUS INFLAMMATION; MIXED CELL FOCUS | ||||
| SPLEEN: GRANULOMATOUS INFLAMMATION | ||||
| MM: SOME EVIDENCE | THYROID GLAND: FOLLICULAR CELL ADENOMA 0/50 1/50 0/50 7/50 | |||
| LIVER: ADENOMA 7/50 14/50 13/50 18/50 CARCINOMA 4/50 8/50 14/50 6/50 COMBINED 10/50 22/50 22/50 22/50 | ||||
| NON-NEOPLASTIC LESIONS: | THYROID GLAND: FOLLICULAR CELL HYPERPLASIA; FOLLICULAR CELL HYPERTROPHY | |||
| LIVER: HEPATOCYTE CYTOPLASMIC ALTERATION; HEPATOCYTE KARYOMEGALY; KUPFFER CELL PIGMENTATION | ||||
| SPLEEN: HEMATOPOIETIC CELL PROLIFERATION; PIGMENTATION; LYMPHOID FOLLICLE ATROPHY | ||||
| BONE MARROW: HYPERPLASIA | ||||
| KIDNEY: PIGMENTATION | ||||
| EPIDIDYMIS: CHRONIC ACTIVE INFLAMMATION; SPERM GRANULOMA | ||||
| TESTES: GERMINAL EPITHELIAL ATROPHY | ||||
| FM: SOME EVIDENCE | LIVER: ADENOMA 3/50 4/49 6/49 10/50 | |||
| NON-NEOPLASTIC LESIONS: | THYROID GLAND: FOLLICULAR CELL HYPERPLASIA; FOLLICULAR CELL HYPERTROPHY | |||
| SPLEEN: HEMATOPOIETIC CELL PROLIFERATION; PIGMENTATION | ||||
Web page last updated on February 10, 2006
