National Toxicology Program

CASRN: 693-98-1

Related: 822-36-6 (4-METHYLIMIDAZOLE)

Formula: C4-H6-N2

Synonyms/Common Names:

• 1H-IMIDAZOLE, 2-METHYL (9CI)
• 2-METHYLGLYOXALINE
• 2-MI

Known Uses:

USED IN THE MANUFACTURE OF PHARMACEUTICALS, PHOTOGRAPHIC & PHOTOTHERMOGRAPHIC CHEMICALS, DYES, PIGMENTS, AGRICULTURAL CHEMICALS & RUBBER. USED IN EPOXY RESIN SYSTEMS FOR SEMICONDUCTOR POTTING COMPOUNDS AND SOLDERING MASKS. COMPONENT OF POLYMERS INCLUDING EPOXY RESIN PASTES, ACRYLIC RUBBER-FLUORORUBBER LAMINATES, FILMS, ADHESIVES, TEXTILE FINISHES AND EPOXY SILANE COATINGS.

Nomination Background

Short-Term Toxicity

• 2-WEEK (Dosed-Feed)  (C92012) Completed 
  • TOX-67 (NTIS No. PB2004-105393)  (Peer Review 04/22/2003)   (Toxicity Peer Review 06/15/2002)
    Toxicity Studies of 2-Methylimidazole and 4-Methylimidazole Administered in Feed to F344/N Rats and B6C3F1Mice (CAS No. 693-98-1 and 822-36-6)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0, 78, 215, OR 645 MG/KG M: 0, 183, 500, OR 1500 MG/KG (0, 1200, 3300, OR 10000 PPM IN FEED) 5/SEX/SPECIES/GROUP
• 13-WEEK (Dosed-Feed)  (C92012) Report Complete 
  • TOX-67 (NTIS No. PB2004-105393)  (Peer Review 04/22/2003)   (Toxicity Peer Review 06/15/2002)
    Toxicity Studies of 2-Methylimidazole and 4-Methylimidazole Administered in Feed to F344/N Rats and B6C3F1Mice (CAS No. 693-98-1 and 822-36-6)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0, 625, 1250, 2500, 5000, OR 10000 PPM IN FEED; 10/SEX/DOSE

Long-Term Carcinogenicity

• 2-YEAR (Dosed-Feed)  (C92012B) Report Complete 
  • TR-516 (NTIS No. PB2005-103484)  (Peer Review 05/22/2003)
    Toxicology and Carcinogenesis Studies of 2-Methylimidazole (CAS No. 693-98-1) in F344/N Rats and B6C3F1 Mice (Feed Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Some Evidence 
  • Female Rats Clear Evidence 
  • Male Mice Some Evidence 
  • Female Mice Some Evidence 
  • Dose: MR: 0, 300, 1000, OR 3000 PPM; FR: 0, 1000, 2500, OR 5000 PPM; M: 0, 625, 1250, OR 2500 PPM; 60/SEX/SPECIES/GROUP

Special Studies

• Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (S0331) Completed 
  • Citation: J. OF TOX AND ENVIRON. HEALTH, PART A, 54:121-132 (1998) DISPOSITION OF 2-MI IN RATS. BY SANDERS, JM, GRIFFIN, RJ, BURKA, LT, MATTHEWS HB
  • M Rats: F344/N; M Rats: F344/N
  • Dose: 5, 50, 150 MG/KG ORAL; 5 MG/KG IV

Genetic Toxicology

• Micronucleus  (A05124) Completed 
  • Mice: B6C3F1
  • Male Negative 
• Micronucleus  (A69851) Completed 
  • Mice: B6C3F1
  • Male Positive 
  • Female Positive 
• Micronucleus  (A84932) Completed 
  • Rats: F344
  • Male Negative 
• Salmonella  (A28742) Completed 
  •  Negative