Summaries & Associations of Study Results
TR-441 Init/Prom Comparative Mouse Study (DMBA/TPA/BPO/MNNG)
Target Organs and Levels of Evidence
NTP Technical Report Number 441
Produced from Chemtrack Database 09/19/01
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| INIT/PROM COMPARATIVE MOUSE STUDY (DMBA/TPA/BPO/MNNG) INIT/PROM |
06/21/94 | TUMOR INITIATOR AND PROMOTOR | Topical DMBA/ACETONE (50,25,2.5UG),DMBA 2.5,TPA 5UG,BPO 20MG, DMBA/TPA(2.5,25,50UG/5UG), DMBA/BPO(2.5,25UG/20MG) AND MNNG/ACETONE (1000,500,100UG),MNNG 100UG,TPA 5UG,BPO 20MG,MNNG/BPO (100,500,1000UG/20MG), MNNG/TPA(100,1000UG/5UG) | Battelle Columbus Laboratory |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| NOTE: | ONE YEAR DERMAL INITIATION/PROMOTION STUDY IN MALE AND FEMALE B6C3F1 MICE, SWISS CD-1 MICE, AND SENCAR MICE TO COMPARE SENSITIVITY TO DERMAL CARCINOGENICITY WITH DMBA OR MMNG AS INITIATORS AND TPA OR BPO AS PROMOTERS. | |||
| NOTE: | ONE YEAR DERMAL INITIATION/PROMOTION STUDY IN MALE AND FEMALE B6C3F1 MICE, SWISS CD-1 MICE, AND SENCAR MICE TO COMPARE SENSITIVITY TO DERMAL CARCINOGENICITY WITH DMBA OR MMNG AS INITIATORS AND TPA OR BPO AS PROMOTERS. | |||
| INIT/PROM COMPARATIVE MOUSE STUDY (DMBA/TPA/BPO/MNNG) INIT/PROM |
06/21/94 | TUMOR INITIATOR AND PROMOTOR | Topical DMBA/ACETONE (25,2.5,.25UG),DMBA 2.5,TPA 5 UG,BPO 20MG, DMBA/TPA(.25,2.5,25/5UG), DMBA/BPO(2.5,25UG/20MG) AND MNNG/ACETONE (1000,500,100UG),MNNG 100UG,TPA 5UG,BPO 20MG,MNNG/BPO (100,500,1000UG/20MG), MNNG/TPA(1000,1000UG/5UG) | Battelle Columbus Laboratory |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| NOTE: | ONE YEAR DERMAL INITIATION/PROMOTION STUDY IN MALE AND FEMALE B6C3F1 MICE, SWISS CD-1 MICE, AND SENCAR MICE TO COMPARE SENSITIVITY TO DERMAL CARCINOGENICITY WITH DMBA OR MMNG AS INITIATORS AND TPA OR BPO AS PROMOTERS. | |||
| NOTE: | ONE YEAR DERMAL INITIATION/PROMOTION STUDY IN MALE AND FEMALE B6C3F1 MICE, SWISS CD-1 MICE, AND SENCAR MICE TO COMPARE SENSITIVITY TO DERMAL CARCINOGENICITY WITH DMBA OR MMNG AS INITIATORS AND TPA OR BPO AS PROMOTERS. | |||
| INIT/PROM COMPARATIVE MOUSE STUDY (DMBA/TPA/BPO/MNNG) INIT/PROM |
06/21/94 | TUMOR INITIATOR AND PROMOTOR | Topical DMBA/ACETONE (25,2.5,.25UG):DMBA 2.5:TPA 1UG:BPO 20MG: DMBA/TPA(.25,2.5,25/1UG): DMBA/BPO(2.5,25UG/20MG) AND MNNG/ACETONE (1000,500,100UG):MNNG 100UG:TPA 5UG:BPO 20MG: MNNG/BPO(100,500,1000 UG/20MG) | Battelle Columbus Laboratory |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| NOTE: | ONE YEAR DERMAL INITIATION/PROMOTION STUDY IN MALE AND FEMALE B6C3F1 MICE, SWISS CD-1 MICE, AND SENCAR MICE TO COMPARE SENSITIVITY TO DERMAL CARCINOGENICITY WITH DMBA OR MMNG AS INITIATORS AND TPA OR BPO AS PROMOTERS. | |||
| NOTE: | ONE YEAR DERMAL INITIATION/PROMOTION STUDY IN MALE AND FEMALE B6C3F1 MICE, SWISS CD-1 MICE, AND SENCAR MICE TO COMPARE SENSITIVITY TO DERMAL CARCINOGENICITY WITH DMBA OR MMNG AS INITIATORS AND TPA OR BPO AS PROMOTERS. | |||
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