National Toxicology Program

CASRN: INIT/PROM

Formula: C20-H16+C56-H56-O8+C14-H10-O4+C2-H5-N5-O3

Synonyms/Common Names:

• Benzoyl peroxide
• Benzoyl peroxide
• 7,12-DIMETHYLBENZ(A)ANTHRACENE
• 7,12-DIMETHYLBENZ(A)ANTHRACENE (DMBA)
• DMBA/TPA/BPO/MNNG
• N-METHYL-N'-NITRO-N-NITROSOGUANIDINE
• N-METHYL-N'-NITRO-N-NITROSOGUANIDINE (MNNG)
• TETRADECANOYLPHORBOL ACETATE (TPA)
• TETRADECANOYLPHORBOL ACETATE

Secondary:

• 94-36-0 - Benzoyl peroxide
• 57-97-6 - 7,12-Dimethylbenzanthracene
• 70-25-7 - 1-Methyl-3-nitro-1-nitroso-guanidine
• 16561-29-8 - Tetradecanoyl phorbol acetate (TPA)
• 16561-29-8 - Transgenic LECM (Tetradecanoyl phorbol acetate (TPA))

Known Uses:

TUMOR INITIATOR AND PROMOTOR

Long-Term Carcinogenicity

• 1-YEAR (Topical Application)  (C61994A) Report Complete 
  • TR-441 (NTIS No. PB96-214655)  (Peer Review 06/21/1994)
    Comparative Initiation/Promotion Skin Paint Studies of B6C3F1 Mice, Swiss (CD-1®) Mice, and Sencar Mice
  • Mice: B6C3F1; Mice: B6C3F1
  • Dose: DMBA/ACETONE(50,25,2.5UG),DMBA 2.5,TPA 5UG,BPO 20MG,DMBA/TPA(2.5,25,50UG/5UG),DMBA/BPO(2.5,25UG/20MG) AND MNNG/ACETONE(1000,500,100UG),MNNG 100UG,TPA 5UG,BPO 20MG,MNNG/BPO(100,500,1000UG/20MG),MNNG/TPA(100,1000UG/5UG)
• 1-YEAR (Topical Application)  (C61994B) Report Complete 
  • TR-441 (NTIS No. PB96-214655)  (Peer Review 06/21/1994)
    Comparative Initiation/Promotion Skin Paint Studies of B6C3F1 Mice, Swiss (CD-1®) Mice, and Sencar Mice
  • Mice: Swiss CD-1; Mice: Swiss CD-1
  • Dose: DMBA/ACETONE(25,2.5,.25UG),DMBA 2.5,TPA 5 UG,BPO 20MG,DMBA/TPA(.25,2.5,25/5UG),DMBA/BPO(2.5,25UG/20MG) AND MNNG/ACETONE(1000,500,100UG),MNNG 100UG,TPA 5UG,BPO 20MG,MNNG/BPO(100,500,1000UG/20MG),MNNG/TPA(1000,1000UG/5UG)
• 1-YEAR (Topical Application)  (C61994C) Report Complete 
  • TR-441 (NTIS No. PB96-214655)  (Peer Review 06/21/1994)
    Comparative Initiation/Promotion Skin Paint Studies of B6C3F1 Mice, Swiss (CD-1®) Mice, and Sencar Mice
  • Mice: B6C3F1; Mice: Swiss CD-1; Mice: Sencar
  • Dose: DMBA/ACETONE(25,2.5,.25UG):DMBA 2.5:TPA 1UG:BPO 20MG:DMBA/TPA(.25,2.5,25/1UG):DMBA/BPO(2.5,25UG/20MG) AND MNNG/ACETONE(1000,500,100UG):MNNG 100UG:TPA 5UG:BPO 20MG:MNNG/BPO(100,500,1000 UG/20MG)