Summaries & Associations of Study Results
TR-436 Tert-Butyl Alcohol
Target Organs and Levels of Evidence
NTP Technical Report Number 436
Produced from Chemtrack Database 09/19/01
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| TERT-BUTYL ALCOHOL 75-65-0 |
06/21/94 | WIDELY USED IN THE MANUFACTURE OF PERFUMES AND A VARIETY OF COSMETICS. IT IS ALSO USED AS A RAW MATERIAL IN THE PRODUCTION OF ISOBUTYLENE, WHICH MAY BE USED TO PRODUCE METHYL TERTIARY BUTYL ETHER, A COMMON GASOLINE ADDITIVE, OR TO PRODUCE BUTYL ELASTOMERS USED IN THE PRODUCTION OF AUTOMOBILE TIRES. | Dosed-Water R: 0,0.125, 0.25, 0.5%(M). 0, 0.25, 0.5, 1.0%(F). M:0,0.5,1.0,2.0%(M&F)/50 PER GROUP | Southern Research Institute |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: SOME EVIDENCE | KIDNEY TUBULAR CELL: (SINGLE SECTIONS) ADENOMA 1/50 3/50 4/50 2/50 OR CARCINOMA 0/50 0/50 0/50 1/50 COMBINED 1/50 3/50 4/50 3/50; (SINGLE AND STEP SECTIONS) ADENOMA 8/50 11/50 19/50 13/50 OR CARCINOMA 0/50 2/50 1/50 1/50 COMBINED 8/50 13/50 19/50 13/50 | |||
| NON-NEOPLASTIC LESIONS: | KIDNEY: MINERALIZATION; TRANSITIONAL EPITHELIAL HYPERPLASIA; INCREASED SEVERITY OF NEPHROPATHY; RENAL TUBULE HYPERPLASIA | |||
| FR: NO EVIDENCE | ||||
| NON-NEOPLASTIC LESIONS: | KIDNEY: TRANSITIONAL EPITHELIAL HYPERPLASIA; INCREASED SEVERITY OF NEPHROPATHY | |||
| MM: EQUIVOCAL EVIDENCE | THYROID GLAND FOLLICULAR CELL: ADENOMA 1/60 0/59 4/59 1/57 OR CARCINOMA 0/60 0/59 0/59 1/57 COMBINED 1/60 0/59 4/59 2/57 | |||
| NON-NEOPLASTIC LESIONS: | THYROID GLAND: FOLLICULAR CELL HYPERPLASIA | |||
| URINARY BLADDER: CHRONIC INFLAMMATION; TRANSITIONAL EPITHELIAL HYPERPLASIA | ||||
| FM: SOME EVIDENCE | THYROID GLAND FOLLICULAR CELL: ADENOMA 2/58 3/60 2/59 9/59 | |||
| NON-NEOPLASTIC LESIONS: | THYROID GLAND: FOLLICULAR CELL HYPERPLASIA | |||
| URINARY BLADDER: CHRONIC INFLAMMATION; TRANSITIONAL EPITHELIAL HYPERPLASIA | ||||
Web page last updated on February 10, 2006
