Testing Information

Testing Status of Agents at NTP

tert-Butyl alcohol

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http://ntp.niehs.nih.gov/go/TS-10402-N

CASRN: 75-65-0

Formula: C4 H10 O

Synonyms/Common Names:

  • T-BUTANOL
  • TERT-BUTANOL
  • T-BUTYL HYDROXIDE
  • 2-METHYLPROPAN-2-OL
  • 2-METHYL-2-PROPANOL
  • TBA
  • TERTIARY BUTYL ALCOHOL
  • TRIMETHYL CARBINOL
  • TRIMETHYL METHANOL

Known Uses:

WIDELY USED IN THE MANUFACTURE OF PERFUMES AND A VARIETY OF COSMETICS. IT IS ALSO USED AS A RAW MATERIAL IN THE PRODUCTION OF ISOBUTYLENE, WHICH MAY BE USED TO PRODUCE METHYL TERTIARY BUTYL ETHER, A COMMON GASOLINE ADDITIVE, OR TO PRODUCE BUTYL ELASTOMERS USED IN THE PRODUCTION OF AUTOMOBILE TIRES.

Short-Term Toxicity

  • 14-Day (Inhalation)  (C55367C) Completed 
    • TOX-53 (NTIS No. PB98-108905)  (Peer Review 11/00/1996)   (Toxicity Peer Review 09/01/1996)
      Toxicity Studies oft-Butyl Alcohol Administered in F344/N Rats and B6C3F1Mice (Inhalation Studies) (CAS No. 75-65-0)
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Water)  (C55367B) Completed 
    • NTIS No. PB96-162748  (Peer Review 06/21/1994)
      Citation: Toxicology and Carcinogenesis Studies oft-Butyl Alcohol (CAS No. 75-65-0) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 2.5, 5, 10, 20, 40 MG/ML 10/GROUP
  • 13-WEEK (Inhalation)  (C55367C) Report Complete 
    • TOX-53 (NTIS No. PB98-108905)  (Peer Review 11/00/1996)   (Toxicity Peer Review 09/01/1996)
      Toxicity Studies oft-Butyl Alcohol Administered in F344/N Rats and B6C3F1Mice (Inhalation Studies) (CAS No. 75-65-0)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 135, 270, 540, 1080, OR 2100 PPM

Long-Term Carcinogenicity

  • 2-YEAR (Dosed-Water)  (C55367B) Report Complete 
    • TR-436 (NTIS No. PB96-162748)  (Peer Review 06/21/1994)
      Toxicology and Carcinogenesis Studies oft-Butyl Alcohol (CAS No. 75-65-0) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats No Evidence 
      • Male Mice Equivocal Evidence 
      • Female Mice Some Evidence 
    • Dose: MALE RATS: 0, 1.25, 2.5, 5 MG/ML; FEMALE RATS: 0, 2.5, 5, 10 MG/ML; MICE 0, 5, 10, 20 MG/ML/60 PER GROUP

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (263726) Completed 
    • Chromosome Aberation Negative 
    • Sister Chromatid Exchange Negative 
  • Mouse Lymphoma  (097469) Completed 
    • Citation: McGregor, D.B., Brown, A., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. II. 18 coded chemicals. Environ. Molec. Mutagen. Vol. 11 (1988) 91-118
    •  Negative 
  • Micronucleus  (A00971) Completed 
    • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Micronucleus  (A26596) Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Micronucleus  (A50244) Completed 
    • Rats: F344
    • Male Negative 
  • Salmonella  (875987) Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., Mortelmans, K., and Speck, W. Salmonella mutagenicity tests. III. Results from the testing of 225 chemicals Environ. Mutagen. Vol. 9 (Suppl 9) (1987) 1-109
    •  Negative 

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Web page last updated on January 22, 2009