Study Results & Research Projects

Summaries & Associations of Study Results

TR-422 Coumarin

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http://ntp.niehs.nih.gov/go/10493

Target Organs and Levels of Evidence
NTP Technical Report Number 422

Produced from Chemtrack Database 09/19/01

CHEMICAL/ CAS NUMBER PEER REVIEW DATE PRIMARY USES ROUTE/EXPOSURE LEVELS STUDY LABORATORY
COUMARIN
91-64-5 		06/23/92 ODOR ENHANCING AGENT IN PERFUMES. PHARMACEUTIC AID (FLAVOR). (TDB) Gavage R: 0,25,50,100; M: 0,50,100,200 MG/KG/60 & 70 PER GROUP RESPECTIVELY American Biogenics Corp (Bioassay Systems)
LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM):
MR: SOME EVIDENCE KIDNEY TUBULAR CELL: ADENOMA 1/49 2/50 2/51 1/50, STEP SECTIONS 0/49 4/50 5/51 4/50
NON-NEOPLASTIC LESIONS: LIVER: CYTOLOGIC ALTERATIONS; FIBROSIS; NECROSIS; BILE DUCT HYPERPLASIA
FORESTOMACH: ULCER
PARATHYROID GLAND: HYPERPLASIA
KIDNEY: INCREASED SEVERITY OF NEPHROPATHY
FR: EQUIVOCAL EVIDENCE KIDNEY TUBULAR CELL: ADENOMA 0/49 0/50 0/50 2/49, STEP SECTIONS 0/49 0/50 1/50 1/49
NON-NEOPLASTIC LESIONS: LIVER: FIBROSIS; NECROSIS; DEGENERATION; BILE DUCT HYPERPLASIA
FORESTOMACH: ULCER
KIDNEY: INCREASED SEVERITY OF NEPHROPATHY
MM: SOME EVIDENCE LUNG: ALVEOLAR/BRONCHIOLAR ADENOMA 14/50 8/50 14/50 24/51 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 1/50 2/50 1/51 COMBINED 14/50 9/50 15/50 25/51
MAY HAVE BEEN RELATED: FORESTOMACH: SQUAMOUS CELL PAPILLOMA 2/50 8/50 2/50 0/51
NON-NEOPLASTIC LESIONS: LIVER: SYNCYTIAL ALTERATION; CENTRILOBULAR HYPERTROPHY; EOSINOPHILIC FOCUS
FM: CLEAR EVIDENCE LUNG: ALVEOLAR/BRONCHIOLAR ADENOMA 2/51 5/49 7/49 20/51 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/51 0/49 0/49 7/51 COMBINED 2/51 5/49 7/49 27/51
LIVER: ADENOMA 8/50 26/49 29/51 12/50
MAY HAVE BEEN RELATED: FORESTOMACH: SQUAMOUS CELL PAPILLOMA 1/52 5/50 2/51 2/51
NON-NEOPLASTIC LESIONS: LIVER: SYNCYTIAL ALTERATION; CENTRILOBULAR HYPERTROPHY; EOSINOPHILIC FOCUS

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