National Toxicology Program

CASRN: 91-64-5

Formula: C9-H6-O2

Synonyms/Common Names:

• 2H-1-BENZOPYRAN-2-ONE

Known Uses:

ODOR ENHANCING AGENT IN PERFUMES. PHARMACEUTIC AID (FLAVOR). (TDB)

Short-Term Toxicity

• 14-Day (Gavage)  (C07103A) Completed 
  • NTIS No. PB94-215761
    Citation: Toxicology and Carcinogenesis Studies of Coumarin (CAS No. 91-64-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Gavage)  (C07103A) Completed 
  • NTIS No. PB94-215761
    Citation: Toxicology and Carcinogenesis Studies of Coumarin (CAS No. 91-64-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R: 0,25,400, M: 0,30,150 MG/KG/5 PER GROUP

Long-Term Carcinogenicity

• 2-YEAR (Gavage)  (C07103B) Report Complete 
  • TR-422 (NTIS No. PB94-215761)  (Peer Review 06/23/1992)
    Toxicology and Carcinogenesis Studies of Coumarin (CAS No. 91-64-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats Some Evidence 
  • Female Rats Equivocal Evidence 
  • Male Mice Some Evidence 
  • Female Mice Clear Evidence 
  • Dose: R: 0,25,50,100; M: 0,50,100,200 MG/KG/60 & 70 PER GROUP RESPECTIVELY

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (020274) Completed 
  • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
  • Chromosome Aberation Weakly Positive 
  • Sister Chromatid Exchange Positive 
• Drosophila  (496820) Completed 
  • Citation: Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Drosophila  (737193) Completed 
  • Citation: Valencia, R., Mason, J.M., and Zimmering, S. Chemical mutagenesis testing in Drosophila. IV. Interlaboratory comparison of mutagenicity tests after treatment of larvae. Environ. Molec. Mutagen. Vol. 14 (1989) 238-244
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Drosophila  (820766) Completed 
  • Citation: Valencia, R., Mason, J.M., and Zimmering, S. Chemical mutagenesis testing in Drosophila. IV. Interlaboratory comparison of mutagenicity tests after treatment of larvae. Environ. Molec. Mutagen. Vol. 14 (1989) 238-244
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
• Micronucleus  (A80637) Completed 
  • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
  • Mice: B6C3F1
  • Male Negative 
  • Female Negative 
• Salmonella  (879172) Completed 
  • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
  •  Positive