Summaries & Associations of Study Results
TR-354 Dimethoxane
Target Organs and Levels of Evidence
NTP Technical Report Number 354
Produced from Chemtrack Database 09/19/01
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| DIMETHOXANE 828-00-2 |
10/03/88 | PRESERVATIVE FOR CUTTING OILS, RESIN EMULSIONS, COSMETICS, INKS, AND WATER-BASED PAINTS. ANTIMICROBIAL AGENT IN ADHESIVES AND TEXTILE CHEMICALS. GASOLINE ADDITIVE. | Gavage MR: 0,62.5,125, FR: 0,125,250, M: 0,250,500 MG/KG/60 PER GROUP | Battelle Columbus Laboratory |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MR: NO EVIDENCE | ||||
| NON-NEOPLASTIC LESIONS: | FORESTOMACH: ACANTHOSIS 5/50 9/50 23/50; HYPERKERATOSIS 1/50 0/50 10/50 | |||
| FR: NO EVIDENCE | ||||
| NON-NEOPLASTIC LESIONS: | FORESTOMACH: ACANTHOSIS 0/50 8/50 44/50; HYPERKERATOSIS 0/50 5/50 22/50 | |||
| MM: EQUIVOCAL EVIDENCE | FORESTOMACH: SQUAMOUS CELL PAPILLOMA 2/47 3/47 7/50 OR SQUAMOUS CELL CARCINOMA 0/47 0/47 1/50 COMBINED 2/47 3/47 8/50 | |||
| NON-NEOPLASTIC LESIONS: | FORESTOMACH: ACANTHOSIS 2/47 4/47 20/50; HYPERKERATOSIS 1/47 1/47 23/50; HYPERPLASIA 2/47 7/47 11/50; INFLAMMATION, CHRONIC 0/47 0/47 5/50 | |||
| FM: NO EVIDENCE | ||||
| NON-NEOPLASTIC LESIONS: | FORESTOMACH: ACANTHOSIS 0/49 5/48 23/48; HYPERKERATOSIS 0/49 4/48 27/48; HYPERPLASIA 3/49 14/48 22/48; INFLAMMATION, CHRONIC 0/49 0/48 1/48 | |||
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