National Toxicology Program

CASRN: 828-00-2

Formula: C8-H14-O4

Synonyms/Common Names:

• 2,6-DIMETHYL-1,3-DIOXAN-4-OL ACETATE (9CI)

Known Uses:

PRESERVATIVE FOR CUTTING OILS, RESIN EMULSIONS, COSMETICS, INKS, AND WATER-BASED PAINTS. ANTIMICROBIAL AGENT IN ADHESIVES AND TEXTILE CHEMICALS. GASOLINE ADDITIVE.

Short-Term Toxicity

• 14-Day (Gavage)  (C56213) Completed 
  • NTIS No. PB90-220096  (Peer Review 10/03/1988)
    Citation: Toxicology and Carcinogenesis Studies of Dimethoxane (CAS No. 828-00-2) (Commercial Grade) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
• 13-Week (Gavage)  (C56213) Completed 
  • NTIS No. PB90-220096  (Peer Review 10/03/1988)
    Citation: Toxicology and Carcinogenesis Studies of Dimethoxane (CAS No. 828-00-2) (Commercial Grade) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 0,31.5,500 MG/KG/10 PER GROUP

Long-Term Carcinogenicity

• 2-YEAR (Gavage)  (C56213) Report Complete 
  • TR-354 (NTIS No. PB90-220096)  (Peer Review 10/03/1988)
    Toxicology and Carcinogenesis Studies of Dimethoxane (CAS No. 828-00-2) (Commercial Grade) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats No Evidence 
  • Female Rats No Evidence 
  • Male Mice Equivocal Evidence 
  • Female Mice No Evidence 
  • Dose: MR: 0,62.5,125, FR: 0,125,250, M: 0,250,500 MG/KG/60 PER GROUP

Genetic Toxicology

• In Vitro Cytogenetics (CA/SCE)  (028235) Completed 
  • Chromosome Aberation Positive 
  • Sister Chromatid Exchange Positive 
• Drosophila  (194110) Completed 
  • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
  • Reciprocal Translocation/Sex-Linked Recessive Lethal Positive 
• Salmonella  (742172) Completed 
  • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
  •  Positive