Summaries & Associations of Study Results
TR-349 Pentachlorophenol, Dowicide EC-7
Target Organs and Levels of Evidence
NTP Technical Report Number 349
Produced from Chemtrack Database 09/19/01
| CHEMICAL/ CAS NUMBER | PEER REVIEW DATE | PRIMARY USES | ROUTE/EXPOSURE LEVELS | STUDY LABORATORY |
|---|---|---|---|---|
| PENTACHLOROPHENOL, DOWICIDE EC-7 87-86-5 |
04/18/88 | WOOD PRESERVATIVE, FUNGICIDE, SOIL FUMIGANT FOR TERMITES, PREHARVEST DEFOLIANT, SEED TREATMENT FOR BEANS, PRESERVATIVE FOR PAINT, LEATHER, TEXTILES, INKS, ANTIBACTERIAL AGENT IN DISINFECTANTS & CLEANSERS (HSDB 1990). | Dosed-Feed M: 0, 100, 200, 600 PPM | Battelle Columbus Laboratory |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MM: CLEAR EVIDENCE | LIVER: ADENOMA 5/35 13/48 17/48 32/49 OR CARCINOMA 1/35 7/48 7/48 9/49 COMBINED 6/35 19/48 21/48 34/49 | |||
| ADRENAL GLAND MEDULLA: PHEOCHROMOCYTOMA 0/34 4/48 21/48 44/49 OR MALIGNANT PHEOCHROMOCYTOMA 1/34 0/48 0/48 3/49 COMBINED 1/34 4/48 21/48 45/49 | ||||
| NON-NEOPLASTIC LESIONS: | LIVER: CLEAR CELL FOCUS 0/35 19/48 21/48 19/49; INFLAMMATION, CHRONIC, ACTIVE 0/35 36/48 44/48 43/49; PIGMENTATION 0/35 40/48 37/48 45/49; BILE DUCT, HYPERPLASIA 1/35 3/48 5/48 32/49; HEPATOCYTE, CYTOMEGALY 0/35 48/48 48/48 47/49; HEPATOCYTE, NECROSIS, ACUTE 1/35 47/48 47/48 46/49 | |||
| FM: CLEAR EVIDENCE | VASCULAR SYSTEM (LIVER): HEMANGIOSARCOMA 0/34 1/50 1/49 8/48 | |||
| LIVER: ADENOMA 1/34 3/50 6/49 30/48 OR CARCINOMA 0/34 1/50 0/49 1/48 COMBINED 1/34 4/50 6/49 31/48 | ||||
| ADRENAL GLAND MEDULLA: PHEOCHROMOCYTOMA 0/35 2/49 2/46 38/49 | ||||
| VASCULAR SYSTEM (SPLEEN): HEMANGIOSARCOMA 0/34 0/50 2/50 2/47 | ||||
| NON-NEOPLASTIC LESIONS: | LIVER: CLEAR CELL FOCUS 1/34 2/50 13/49 26/48; INFLAMMATION, CHRONIC, ACTIVE 0/34 4/50 30/49 47/48; PIGMENTATION 0/34 4/50 32/49 48/48; BILE DUCT, HYPERPLASIA 0/34 0/50 1/49 40/48; HEPATOCYTE, CYTOMEGALY 0/34 38/50 49/49 47/48; HEPATOCYTE, NECROSIS, ACUTE 2/34 25/50 49/49 48/48 | |||
| PENTACHLOROPHENOL, TECHNICAL 87-86-5 |
04/18/88 | WOOD PRESERVATIVE, FUNGICIDE, SOIL FUMIGANT FOR TERMITES, PREHARVEST DEFOLIANT, SEED TREATMENT FOR BEANS, PRESERVATIVE FOR PAINT, LEATHER, TEXTILES, INKS, ANTIBACTERIAL AGENT IN DISINFECTANTS & CLEANSERS (HSDB 1990). | Dosed-Feed M: 0, 100, 200 PPM | Battelle Columbus Laboratory |
| LEVELS OF EVIDENCE OF CARCINOGENICITY--ORGAN/TISSUE (NEOPLASM): | ||||
| MM: CLEAR EVIDENCE | LIVER: ADENOMA 5/32 20/47 33/48 OR CARCINOMA 2/32 10/47 12/48 COMBINED 7/32 26/47 37/48 | |||
| ADRENAL GLAND MEDULLA: PHEOCHROMOCYTOMA 0/31 10/45 23/45 | ||||
| FM: SOME EVIDENCE | VASCULAR SYSTEM (LIVER): HEMANGIOSARCOMA 0/33 2/49 4/50 | |||
| LIVER: ADENOMA 3/33 8/49 8/50 OR CARCINOMA 0/33 1/49 1/50 COMBINED 3/33 9/49 9/50 | ||||
| VASCULAR SYSTEM (SPLEEN): HEMANGIOSARCOMA 0/33 1/50 3/47 | ||||
Web page last updated on February 10, 2006
