Testing Information

Testing Status of Agents at NTP

Pentachlorophenol, technical

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http://ntp.niehs.nih.gov/go/TS-11614-A

CASRN: 87-86-5

Formula: C6-H-CL5-O

Known Uses:

WOOD PRESERVATIVE, FUNGICIDE, SOIL FUMIGANT FOR TERMITES, PREHARVEST DEFOLIANT, SEED TREATMENT FOR BEANS, PRESERVATIVE FOR PAINT, LEATHER, TEXTILES, INKS, ANTIBACTERIAL AGENT IN DISINFECTANTS & CLEANSERS (HSDB 1990).

Nomination Background

Short-Term Toxicity

  • 4-WEEK (Dosed-Feed)  (C55378) Completed 
    • NTIS No. PB89-216536  (Peer Review 04/18/1988)
      Citation: Toxicology and Carcinogenesis Studies of Two Pentachlorophenol Technical-Grade Mixtures (CAS No. 87-86-5) in B6C3F1 Mice (Feed Studies)
    • Mice: B6C3F1
  • 26-WEEK (Dosed-Feed)  (C55378) Completed 
    • NTIS No. PB89-216536  (Peer Review 04/18/1988)
      Citation: Toxicology and Carcinogenesis Studies of Two Pentachlorophenol Technical-Grade Mixtures (CAS No. 87-86-5) in B6C3F1 Mice (Feed Studies)
    • Mice: B6C3F1
    • Dose: 0,200,1800 PPM/50 PER GROUP

Long-Term Carcinogenicity

  • 2-YEAR (Dosed-Feed)  (C55378) Report Complete 
    • TR-349 (NTIS No. PB89-216536)  (Peer Review 04/18/1988)
      Toxicology and Carcinogenesis Studies of Two Pentachlorophenol Technical-Grade Mixtures (CAS No. 87-86-5) in B6C3F1 Mice (Feed Studies)
    • Mice: B6C3F1
    • Carcinogenesis Results
      • Male Mice Clear Evidence 
      • Female Mice Some Evidence 
    • Dose: M: 0, 100, 200 PPM

Special Studies

  • Absorption Disposition Metabolism Elimination  (S0446) Completed 
    • Citation: MATTHEWS, H.B., ET.AL., THE CHRONIC TOXICITY OF TECHNICAL & ANALYTICAL PCP IN CATTLE; CHEMICAL ANALYSIS OF TISSUES, TOXICOL & APPL PHARM 55:359-369, 1980.
    • Dose: 160 DAY EXPOSURE APCP, TPCP OR MIXTURE

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (646893) Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Chromosome Aberation Weakly Positive 
    • Sister Chromatid Exchange Weakly Positive 
  • Salmonella  (771899) Completed 
    • Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
    •  Negative 

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Web page last updated on January 22, 2009