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Volume 3(7);  July 2006
Editorial
PLoS Medicine and the Pharmaceutical Industry
The PLoS Medicine Editors
PLoS Med. 2006 July; 3(7): e329. Published online 2006 July 25. doi: 10.1371/journal.pmed.0030329.
PMCID: PMC1518677
The PLoS Medicine Debate
Should Society Allow Research Ethics Boards to Be Run As For-Profit Enterprises?
Ezekiel J Emanuel, Trudo Lemmens, and Carl Elliot
PLoS Med. 2006 July; 3(7): e309. Published online 2006 July 25. doi: 10.1371/journal.pmed.0030309.
PMCID: PMC1518668
Essays
The State of Child Health and Human Rights in Nepal
Sonal Singh, Erik Bøhler, Khagendra Dahal, and Edward Mills
PLoS Med. 2006 July; 3(7): e203. Published online 2006 July 4. doi: 10.1371/journal.pmed.0030203.
PMCID: PMC1483907
The Clinical Applications of a Systems Approach
Andrew C Ahn, Muneesh Tewari, Chi-Sang Poon, and Russell S Phillips
PLoS Med. 2006 July; 3(7): e209. Published online 2006 May 23. doi: 10.1371/journal.pmed.0030209.
PMCID: PMC1459481
Lessons from Our Patients: Development of a Warm Autopsy Program
Kathleen Oare Lindell, Judith A Erlen, and Naftali Kaminski
PLoS Med. 2006 July; 3(7): e234. Published online 2006 June 6. doi: 10.1371/journal.pmed.0030234.
PMCID: PMC1472556
Do Antidepressants Cure or Create Abnormal Brain States?
Joanna Moncrieff and David Cohen
PLoS Med. 2006 July; 3(7): e240. Published online 2006 June 6. doi: 10.1371/journal.pmed.0030240.
PMCID: PMC1472553
Regulation of Clinical Research Sponsored by Pharmaceutical Companies: A Proposal
Julio Sotelo
PLoS Med. 2006 July; 3(7): e306. Published online 2006 July 11. doi: 10.1371/journal.pmed.0030306.
PMCID: PMC1489183
Perspectives
Immunoprophylaxis against Mother-to-Child Transmission of HIV-1
Miroslaw K Gorny and Susan Zolla-Pazner
PLoS Med. 2006 July; 3(7): e259. Published online 2006 July 18. doi: 10.1371/journal.pmed.0030259.
PMCID: PMC1513047
A New Mouse Model to Study Acquired Lymphedema
Martin Schneider, Annelii Ny, Carmen Ruiz de Almodovar, and Peter Carmeliet
PLoS Med. 2006 July; 3(7): e264. Published online 2006 July 18. doi: 10.1371/journal.pmed.0030264.
PMCID: PMC1513046
The “Ultimate Prize” for Big Tobacco: Opening the Chinese Cigarette Market by Cigarette Smuggling
Thomas E Novotny
PLoS Med. 2006 July; 3(7): e279. Published online 2006 July 18. doi: 10.1371/journal.pmed.0030279.
PMCID: PMC1502150
Anti-Interferon Auto-Antibodies in Autoimmune Polyendocrinopathy Syndrome Type 1
Michael Levin
PLoS Med. 2006 July; 3(7): e292. Published online 2006 June 13. doi: 10.1371/journal.pmed.0030292.
PMCID: PMC1475656
Health in Action
Moving Toward Assured Access to Treatment in Microbicide Trials
Anna Forbes
PLoS Med. 2006 July; 3(7): e153. Published online 2006 July 11. doi: 10.1371/journal.pmed.0030153.
PMCID: PMC1489187
Reducing Disparities in the Burden of Cancer: The Role of Patient Navigators
Tisha Fowler, Caryn Steakley, A. Roland Garcia, Jennifer Kwok, and L. Michelle Bennett
PLoS Med. 2006 July; 3(7): e193. Published online 2006 July 11. doi: 10.1371/journal.pmed.0030193.
PMCID: PMC1489186
Building Surgical Research Capacity in Africa: The Ptolemy Project
Miliard Derbew, Massey Beveridge, Andrew Howard, and Niall Byrne
PLoS Med. 2006 July; 3(7): e305. Published online 2006 July 11. doi: 10.1371/journal.pmed.0030305.
PMCID: PMC1489182
Policy Forum
Enrolling Adolescents in Research on HIV and Other Sensitive Issues: Lessons from South Africa
Jerome Amir Singh, Salim S Abdool Karim, Quarraisha Abdool Karim, Koleka Mlisana, Carolyn Williamson, Clive Gray, Michelle Govender, and Andrew Gray
PLoS Med. 2006 July; 3(7): e180. Published online 2006 April 18. doi: 10.1371/journal.pmed.0030180.
PMCID: PMC1435780
A Survey of Public Funding of Cancer Research in the European Union
Seth Eckhouse and Richard Sullivan
PLoS Med. 2006 July; 3(7): e267. Published online 2006 July 18. doi: 10.1371/journal.pmed.0030267.
PMCID: PMC1513045
Training and HIV-Treatment Scale-Up: Establishing an Implementation Research Agenda
Elizabeth A McCarthy, Megan E O'Brien, and William R Rodriguez
PLoS Med. 2006 July; 3(7): e304. Published online 2006 July 4. doi: 10.1371/journal.pmed.0030304.
PMCID: PMC1483909
Research in Translation
Silencing Viral Infection
Derek M Dykxhoorn and Judy Lieberman
PLoS Med. 2006 July; 3(7): e242. Published online 2006 July 25. doi: 10.1371/journal.pmed.0030242.
PMCID: PMC1518680
Research Articles
Embryonic Pig Pancreatic Tissue Transplantation for the Treatment of Diabetes
Smadar Eventov-Friedman, Dalit Tchorsh, Helena Katchman, Elias Shezen, Anna Aronovich, Gil Hecht, Benjamin Dekel, Gideon Rechavi, Bruce R Blazar, Ilan Feine, Orna Tal, Enrique Freud, and Yair Reisner
PLoS Med. 2006 July; 3(7): e215. Published online 2006 June 20. doi: 10.1371/journal.pmed.0030215.
PMCID: PMC1479387
The BARD1 Cys557Ser Variant and Breast Cancer Risk in Iceland
Simon N Stacey, Patrick Sulem, Oskar T Johannsson, Agnar Helgason, Julius Gudmundsson, Jelena P Kostic, Kristleifur Kristjansson, Thora Jonsdottir, Helgi Sigurdsson, Jon Hrafnkelsson, Jakob Johannsson, Thorarinn Sveinsson, Gardar Myrdal, Hlynur Niels Grimsson, Jon T Bergthorsson, Laufey T Amundadottir, Jeffrey R Gulcher, Unnur Thorsteinsdottir, Augustine Kong, and Kari Stefansson
PLoS Med. 2006 July; 3(7): e217. Published online 2006 June 20. doi: 10.1371/journal.pmed.0030217.
PMCID: PMC1479388
“Key to the Future”: British American Tobacco and Cigarette Smuggling in China
Kelley Lee and Jeff Collin
PLoS Med. 2006 July; 3(7): e228. Published online 2006 July 18. doi: 10.1371/journal.pmed.0030228.
PMCID: PMC1502159
Predicting Survival within the Lung Cancer Histopathological Hierarchy Using a Multi-Scale Genomic Model of Development
Hongye Liu, Alvin T Kho, Isaac S Kohane, and Yao Sun
PLoS Med. 2006 July; 3(7): e232. Published online 2006 July 4. doi: 10.1371/journal.pmed.0030232.
PMCID: PMC1483910
Human Monoclonal Antibody Combination against SARS Coronavirus: Synergy and Coverage of Escape Mutants
Jan ter Meulen, Edward N van den Brink, Leo L. M Poon, Wilfred E Marissen, Cynthia S. W Leung, Freek Cox, Chung Y Cheung, Arjen Q Bakker, Johannes A Bogaards, Els van Deventer, Wolfgang Preiser, Hans Wilhelm Doerr, Vincent T Chow, John de Kruif, Joseph S. M Peiris, and Jaap Goudsmit
PLoS Med. 2006 July; 3(7): e237. Published online 2006 July 4. doi: 10.1371/journal.pmed.0030237.
PMCID: PMC1483912
Uptake of Workplace HIV Counselling and Testing: A Cluster-Randomised Trial in Zimbabwe
Elizabeth L Corbett, Ethel Dauya, Ronnie Matambo, Yin Bun Cheung, Beauty Makamure, Mary T Bassett, Steven Chandiwana, Shungu Munyati, Peter R Mason, Anthony E Butterworth, Peter Godfrey-Faussett, and Richard J Hayes
PLoS Med. 2006 July; 3(7): e238. Published online 2006 July 4. doi: 10.1371/journal.pmed.0030238.
PMCID: PMC1483908
Cost-Effectiveness of Treating Multidrug-Resistant Tuberculosis
Stephen C Resch, Joshua A Salomon, Megan Murray, and Milton C Weinstein
PLoS Med. 2006 July; 3(7): e241. Published online 2006 July 4. doi: 10.1371/journal.pmed.0030241.
PMCID: PMC1483913
Inflammatory Manifestations of Experimental Lymphatic Insufficiency
Raymond Tabibiazar, Lauren Cheung, Jennifer Han, Jeffrey Swanson, Andreas Beilhack, Andrew An, Soheil S Dadras, Ned Rockson, Smita Joshi, Roger Wagner, and Stanley G Rockson
PLoS Med. 2006 July; 3(7): e254. Published online 2006 July 18. doi: 10.1371/journal.pmed.0030254.
PMCID: PMC1502157
Insensitivity of Paediatric HIV-1 Subtype C Viruses to Broadly Neutralising Monoclonal Antibodies Raised against Subtype B
Elin Solomonovna Gray, Tammy Meyers, Glenda Gray, David Charles Montefiori, and Lynn Morris
PLoS Med. 2006 July; 3(7): e255. Published online 2006 July 18. doi: 10.1371/journal.pmed.0030255.
PMCID: PMC1502151
Advice from a Medical Expert through the Internet on Queries about AIDS and Hepatitis: Analysis of a Pilot Experiment
Javier Marco, Raquel Barba, Juan E Losa, Carlos Martínez de la Serna, María Sainz, Isabel Fernández Lantigua, and Jose Luis de la Serna
PLoS Med. 2006 July; 3(7): e256. Published online 2006 July 4. doi: 10.1371/journal.pmed.0030256.
PMCID: PMC1483911
Routine HIV Testing in Botswana: A Population-Based Study on Attitudes, Practices, and Human Rights Concerns
Sheri D Weiser, Michele Heisler, Karen Leiter, Fiona Percy-de Korte, Sheila Tlou, Sonya DeMonner, Nthabiseng Phaladze, David R Bangsberg, and Vincent Iacopino
PLoS Med. 2006 July; 3(7): e261. Published online 2006 July 18. doi: 10.1371/journal.pmed.0030261.
PMCID: PMC1502152
The Potential Impact of Male Circumcision on HIV in Sub-Saharan Africa
Brian G Williams, James O Lloyd-Smith, Eleanor Gouws, Catherine Hankins, Wayne M Getz, John Hargrove, Isabelle de Zoysa, Christopher Dye, and Bertran Auvert
PLoS Med. 2006 July; 3(7): e262. Published online 2006 July 11. doi: 10.1371/journal.pmed.0030262.
PMCID: PMC1489185
Genome Microevolution of Chikungunya Viruses Causing the Indian Ocean Outbreak
Isabelle Schuffenecker, Isabelle Iteman, Alain Michault, Séverine Murri, Lionel Frangeul, Marie-Christine Vaney, Rachel Lavenir, Nathalie Pardigon, Jean-Marc Reynes, François Pettinelli, Leon Biscornet, Laure Diancourt, Stéphanie Michel, Stéphane Duquerroy, Ghislaine Guigon, Marie-Pascale Frenkiel, Anne-Claire Bréhin, Nadège Cubito, Philippe Desprès, Frank Kunst, Félix A Rey, Hervé Zeller, and Sylvain Brisse
PLoS Med. 2006 July; 3(7): e263. Published online 2006 May 23. doi: 10.1371/journal.pmed.0030263.
PMCID: PMC1463904
MPLW515L Is a Novel Somatic Activating Mutation in Myelofibrosis with Myeloid Metaplasia
Yana Pikman, Benjamin H Lee, Thomas Mercher, Elizabeth McDowell, Benjamin L Ebert, Maricel Gozo, Adam Cuker, Gerlinde Wernig, Sandra Moore, Ilene Galinsky, Daniel J DeAngelo, Jennifer J Clark, Stephanie J Lee, Todd R Golub, Martha Wadleigh, D. Gary Gilliland, and Ross L Levine
PLoS Med. 2006 July; 3(7): e270. Published online 2006 July 18. doi: 10.1371/journal.pmed.0030270.
PMCID: PMC1502153
Anti-Interferon Autoantibodies in Autoimmune Polyendocrinopathy Syndrome Type 1
Anthony Meager, Kumuthini Visvalingam, Pärt Peterson, Kaidi Möll, Astrid Murumägi, Kai Krohn, Petra Eskelin, Jaakko Perheentupa, Eystein Husebye, Yoshihisa Kadota, and Nick Willcox
PLoS Med. 2006 July; 3(7): e289. Published online 2006 June 13. doi: 10.1371/journal.pmed.0030289.
PMCID: PMC1475653
Mutation of von Hippel–Lindau Tumour Suppressor and Human Cardiopulmonary Physiology
Thomas G Smith, Jerome T Brooks, George M Balanos, Terence R Lappin, D. Mark Layton, Dawn L Leedham, Chun Liu, Patrick H Maxwell, Mary F McMullin, Christopher J McNamara, Melanie J Percy, Christopher W Pugh, Peter J Ratcliffe, Nick P Talbot, Marilyn Treacy, and Peter A Robbins
PLoS Med. 2006 July; 3(7): e290. Published online 2006 June 20. doi: 10.1371/journal.pmed.0030290.
PMCID: PMC1479389
Correspondence and Other Communications
Confessions of a Disease Monger
James Phelps
PLoS Med. 2006 July; 3(7): e314. Published online 2006 July 25. doi: 10.1371/journal.pmed.0030314.
PMCID: PMC1518679
Fairness Creams in South Asia—A Case of Disease Mongering?
P. Ravi Shankar, Bishnu Rath Giri, and Subish Palaian
PLoS Med. 2006 July; 3(7): e315. Published online 2006 July 25. doi: 10.1371/journal.pmed.0030315.
PMCID: PMC1518681
Disease Mongering: One of the Hidden Consequences
Kenneth Gillman
PLoS Med. 2006 July; 3(7): e316. Published online 2006 July 25. doi: 10.1371/journal.pmed.0030316.
PMCID: PMC1518684
Defining Disease in the Information Age
Olavo B Amaral
PLoS Med. 2006 July; 3(7): e317. Published online 2006 July 25. doi: 10.1371/journal.pmed.0030317.
PMCID: PMC1518688
There Is No Such Thing as a Psychiatric Disorder/Disease/Chemical Imbalance
Fred Baughman
PLoS Med. 2006 July; 3(7): e318. Published online 2006 July 25. doi: 10.1371/journal.pmed.0030318.
PMCID: PMC1518691
The Newest Mania: Seeing Disease Mongering Everywhere
S. Nassir Ghaemi
PLoS Med. 2006 July; 3(7): e319. Published online 2006 July 25. doi: 10.1371/journal.pmed.0030319.
PMCID: PMC1518696
The Best Hysterias: Author's Response to Ghaemi
David Healy
PLoS Med. 2006 July; 3(7): e320. Published online 2006 July 25. doi: 10.1371/journal.pmed.0030320.
PMCID: PMC1518689
Questionable Advertising of Psychotropic Medications and Disease Mongering
Jeffrey R Lacasse and Jonathan Leo
PLoS Med. 2006 July; 3(7): e321. Published online 2006 July 25. doi: 10.1371/journal.pmed.0030321.
PMCID: PMC1518694
Taiwan's Potential to Assist Developing Countries to Combat Infectious Diseases
Govindasamy Agoramoorthy and Minna J Hsu
PLoS Med. 2006 July; 3(7): e322. Published online 2006 July 25. doi: 10.1371/journal.pmed.0030322.
PMCID: PMC1518698
Correction
Correction: Advertising in Medical Journals: Should Current Practices Change?
Adriane Fugh-Berman, Karen Alladin, and Jarva Chow
PLoS Med. 2006 July; 3(7): e303. Published online 2006 July 11. doi: 10.1371/journal.pmed.0030303.
PMCID: PMC1489184
Corrects: Adriane Fugh-Berman, et al. Advertising in Medical Journals: Should Current Practices Change? PLoS Med. 2006 June; 3(6): e130.
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