pmc logo imageJournal ListSearchpmc logo image
Logo of pnasPNAS Home page.PNAS Editorial BoardPNAS AboutPNAS SubscriptionsPNAS Info for Authors
This journal provides immediate access to some articles.
Other Issues:  previous | next | latest | archive
Volume 97(11);  May 23, 2000
Commentaries
The many faces of DNA polymerases: Strategies for mutagenesis and for mutational avoidance
Errol C. Friedberg, William J. Feaver, and Valerie L. Gerlach
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5681–5683. Published online 2000 May 16.
PMCID: PMC33986
HSV.com: Maneuvering the internetworks of viral neuropathogenesis and evasion of the host defense
Seng-Lai Tan and Michael G. Katze
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5684–5686.
PMCID: PMC33987
New paradigm for drug therapies of cardiac fibrillation
Alain Karma
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5687–5689.
PMCID: PMC33988
In search of γ-secretase: Presenilin at the cutting edge
Dennis J. Selkoe and Michael S. Wolfe
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5690–5692.
PMCID: PMC33989
Ecological character displacement and the study of adaptation
Jonathan B. Losos
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5693–5695.
PMCID: PMC33990
Functional brain imaging to identify affected subjects genetically at risk for Alzheimer's disease
Stanley I. Rapoport
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5696–5698. Published online 2000 May 16.
PMCID: PMC33991
Physical Sciences
Applied Mathematics
Fast methods for the Eikonal and related Hamilton– Jacobi equations on unstructured meshes
J. A. Sethian and A. Vladimirsky
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5699–5703. Published online 2000 May 16.
PMCID: PMC18495
Chemistry
A route to hierarchical materials based on complexes of metallosupramolecular polyelectrolytes and amphiphiles
Dirk G. Kurth, Pit Lehmann, and Markus Schütte
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5704–5707.
PMCID: PMC18496
Femtosecond linear dichroism of DNA-intercalating chromophores: Solvation and charge separation dynamics of [Ru(phen)2dppz]2+ systems
Björn Önfelt, Per Lincoln, Bengt Nordén, J. Spencer Baskin, and Ahmed H. Zewail
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5708–5713. Published online 2000 May 16.
PMCID: PMC18497
Computer Sciences
High throughput protein fold identification by using experimental constraints derived from intramolecular cross-links and mass spectrometry
Malin M. Young, Ning Tang, Judith C. Hempel, Connie M. Oshiro, Eric W. Taylor, Irwin D. Kuntz, Bradford W. Gibson, and Gavin Dollinger
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5802–5806. Published online 2000 May 16.
PMCID: PMC18514
Physics
What angle-resolved photoemission experiments tell about the microscopic theory for high-temperature superconductors
Elihu Abrahams and C. M. Varma
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5714–5716. Published online 2000 May 16.
PMCID: PMC18498
Biological Sciences
Biochemistry
A mammalian germ cell-specific RNA-binding protein interacts with ubiquitously expressed proteins involved in splice site selection
David J. Elliott, Cyril F. Bourgeois, Albrecht Klink, James Stévenin, and Howard J. Cooke
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5717–5722.
PMCID: PMC18499
Bcl-2 decreases the free Ca2+ concentration within the endoplasmic reticulum
Reyhaneh Foyouzi-Youssefi, Serge Arnaudeau, Christoph Borner, William L. Kelley, Jürg Tschopp, Daniel P. Lew, Nicolas Demaurex, and Karl-Heinz Krause
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5723–5728.
PMCID: PMC18500
Crystallographic snapshots along a protein-induced DNA-bending pathway
Nancy C. Horton and John J. Perona
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5729–5734. Published online 2000 May 9.
PMCID: PMC18501
The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny
Raheel Shafi, Sai Prasad N. Iyer, Lesley G. Ellies, Niall O'Donnell, Kurt W. Marek, Daniel Chui, Gerald W. Hart, and Jamey D. Marth
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5735–5739. Published online 2000 May 9.
PMCID: PMC18502
The tetranucleotide UCAY directs the specific recognition of RNA by the Nova K-homology 3 domain
Kirk B. Jensen, Kiran Musunuru, Hal A. Lewis, Stephen K. Burley, and Robert B. Darnell
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5740–5745. Published online 2000 May 16.
PMCID: PMC18503
Protein oxidation in response to increased transcriptional or translational errors
S. Dukan, A. Farewell, M. Ballesteros, F. Taddei, M. Radman, and T. Nyström
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5746–5749. Published online 2000 May 16.
PMCID: PMC18504
Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans
Sanjeev H. Satyal, Enrico Schmidt, Kazunori Kitagawa, Neal Sondheimer, Susan Lindquist, James M. Kramer, and Richard I. Morimoto
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5750–5755. Published online 2000 May 16.
PMCID: PMC18505
A multipotential β-1,6-N-acetylglucosaminyl-transferase is encoded by bovine herpesvirus type 4
Alain Vanderplasschen, Nicolas Markine-Goriaynoff, Patrick Lomonte, Masami Suzuki, Nobuyoshi Hiraoka, Jiunn-Chern Yeh, Fabrice Bureau, Luc Willems, Etienne Thiry, Minoru Fukuda, and Paul-Pierre Pastoret
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5756–5761. Published online 2000 May 16.
PMCID: PMC18506
Specific interaction of CCR5 amino-terminal domain peptides containing sulfotyrosines with HIV-1 envelope glycoprotein gp120
Emmanuel G. Cormier, Marjan Persuh, Daniah A. D. Thompson, Steven W. Lin, Thomas P. Sakmar, William C. Olson, and Tatjana Dragic
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5762–5767.
PMCID: PMC18507
Steroid hormones induce HMG1 overexpression and sensitize breast cancer cells to cisplatin and carboplatin
Qing He, Cynthia H. Liang, and Stephen J. Lippard
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5768–5772. Published online 2000 May 16.
PMCID: PMC18508
Expression profiling of pancreatic β cells: Glucose regulation of secretory and metabolic pathway genes
Gene C. Webb, Murtaza S. Akbar, Chongjian Zhao, and Donald F. Steiner
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5773–5778. Published online 2000 May 16.
PMCID: PMC18509
A 12(S)-hydroxyeicosatetraenoic acid receptor interacts with steroid receptor coactivator-1
Yuko Kurahashi, Helena Herbertsson, Mats Söderström, Michael G. Rosenfeld, and Sven Hammarström
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5779–5783.
PMCID: PMC18510
Structural diversity of self-cleaving ribozymes
Jin Tang and Ronald R. Breaker
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5784–5789.
PMCID: PMC18511
The major transition state in folding need not involve the immobilization of side chains
Rosemary A. Staniforth, Jonathan L. E. Dean, Qi Zhong, Eva Zerovnik, Anthony R. Clarke, and Jonathan P. Waltho
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5790–5795.
PMCID: PMC18512
Internal packing of helical membrane proteins
Markus Eilers, Srinivasan C. Shekar, Ted Shieh, Steven O. Smith, and Patrick J. Fleming
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5796–5801.
PMCID: PMC18513
High throughput protein fold identification by using experimental constraints derived from intramolecular cross-links and mass spectrometry
Malin M. Young, Ning Tang, Judith C. Hempel, Connie M. Oshiro, Eric W. Taylor, Irwin D. Kuntz, Bradford W. Gibson, and Gavin Dollinger
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5802–5806. Published online 2000 May 16.
PMCID: PMC18514
The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases
Joseph Landry, Ann Sutton, Stefan T. Tafrov, Ryan C. Heller, John Stebbins, Lorraine Pillus, and Rolf Sternglanz
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5807–5811. Published online 2000 May 16.
PMCID: PMC18515
Effective inhibition of human cytomegalovirus gene expression and replication by a ribozyme derived from the catalytic RNA subunit of RNase P from Escherichia coli
Phong Trang, Manfred Lee, Edward Nepomuceno, Joe Kim, Hua Zhu, and Fenyong Liu
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5812–5817. Published online 2000 May 16.
PMCID: PMC18516
Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties
Andre Levchenko, Jehoshua Bruck, and Paul W. Sternberg
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5818–5823.
PMCID: PMC18517
Ser67-phosphorylated inhibitor 1 is a potent protein phosphatase 1 inhibitor
Ke-xue Huang and Hemant K. Paudel
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5824–5829. Published online 2000 May 16.
PMCID: PMC18518
Domain organization and flavin adenine dinucleotide-binding determinants in the aerotaxis signal transducer Aer of Escherichia coli
Sergei I. Bibikov, Lindsey A. Barnes, Yakov Gitin, and John S. Parkinson
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5830–5835. Published online 2000 May 16.
PMCID: PMC18519
Interactions between heterologous forms of prion protein: Binding, inhibition of conversion, and species barriers
Motohiro Horiuchi, Suzette A. Priola, Joëlle Chabry, and Byron Caughey
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5836–5841. Published online 2000 May 16.
PMCID: PMC18520
Structure of a two-domain chitotriosidase from Serratia marcescens at 1.9-Å resolution
D. M. F. van Aalten, B. Synstad, M. B. Brurberg, E. Hough, B. W. Riise, V. G. H. Eijsink, and R. K. Wierenga
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5842–5847.
PMCID: PMC18521
Construction of hybrid peptide synthetases by module and domain fusions
Henning D. Mootz, Dirk Schwarzer, and Mohamed A. Marahiel
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5848–5853. Published online 2000 May 16.
PMCID: PMC18522
Structure and mechanism of mammalian thioredoxin reductase: The active site is a redox-active selenolthiol/selenenylsulfide formed from the conserved cysteine-selenocysteine sequence
Liangwei Zhong, Elias S. J. Arnér, and Arne Holmgren
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5854–5859. Published online 2000 May 9.
PMCID: PMC18523
Dynamic interplay between antagonistic pathways controlling the σ32 level in Escherichia coli
Miyo T. Morita, Masaaki Kanemori, Hideki Yanagi, and Takashi Yura
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5860–5865. Published online 2000 May 9.
PMCID: PMC18524
Biophysics
An essential intermediate in the folding of dihydrofolate reductase
David K. Heidary, John C. O'Neill, Jr., Melinda Roy, and Patricia A. Jennings
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5866–5870. Published online 2000 May 16.
PMCID: PMC18525
How native-state topology affects the folding of dihydrofolate reductase and interleukin-1β
Cecilia Clementi, Patricia A. Jennings, and José N. Onuchic
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5871–5876. Published online 2000 May 16.
PMCID: PMC18526
Reaction coordinates of biomolecular isomerization
Peter G. Bolhuis, Christoph Dellago, and David Chandler
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5877–5882. Published online 2000 May 9.
PMCID: PMC18527
Calcium triggers an intramolecular association of the C2 domains in synaptotagmin
Ricardo A. García, Cameron E. Forde, and Hilary Arnold Godwin
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5883–5888. Published online 2000 May 16.
PMCID: PMC18528
Cell Biology
Endoplasmic reticulum retention is a common defect associated with tyrosinase-negative albinism
Ruth Halaban, Sherri Svedine, Elaine Cheng, Yoel Smicun, Rebecca Aron, and Daniel N. Hebert
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5889–5894.
PMCID: PMC18529
Cloning and characterization of the mammalian brain-specific, Mg2+-dependent neutral sphingomyelinase
Kay Hofmann, Stefan Tomiuk, Gabriela Wolff, and Wilhelm Stoffel
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5895–5900.
PMCID: PMC18530
The ADP ribosylation factor nucleotide exchange factor ARNO promotes β-arrestin release necessary for luteinizing hormone/choriogonadotropin receptor desensitization
Sutapa Mukherjee, Vsevolod V. Gurevich, Jonathan C. R. Jones, James E. Casanova, Scott R. Frank, Evelyn T. Maizels, Marie-France Bader, Richard A. Kahn, Krzysztof Palczewski, Klaus Aktories, and Mary Hunzicker-Dunn
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5901–5906. Published online 2000 May 16.
PMCID: PMC18531
Nuclear clusterin/XIP8, an x-ray-induced Ku70-binding protein that signals cell death
Chin-Rang Yang, Konstantin Leskov, Kelly Hosley-Eberlein, Tracy Criswell, John J. Pink, Timothy J. Kinsella, and David A. Boothman
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5907–5912.
PMCID: PMC18532
Separation of presenilin function in amyloid β-peptide generation and endoproteolysis of Notch
Luka Kulic, Jochen Walter, Gerd Multhaup, David B. Teplow, Ralf Baumeister, Helmut Romig, Anja Capell, Harald Steiner, and Christian Haass
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5913–5918. Published online 2000 May 16.
PMCID: PMC18533
Identification of a human centrosomal calmodulin-binding protein that shares homology with pericentrin
Mark R. Flory, Michael J. Moser, Raymond J. Monnat, Jr., and Trisha N. Davis
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5919–5923.
PMCID: PMC18534
Ski acts as a co-repressor with Smad2 and Smad3 to regulate the response to type β transforming growth factor
Weidong Xu, Konstantina Angelis, David Danielpour, Maher M. Haddad, Oliver Bischof, Judith Campisi, Ed Stavnezer, and Estela E. Medrano
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5924–5929. Published online 2000 May 16.
PMCID: PMC18535
Human vascular endothelial cells contain membrane binding sites for estradiol, which mediate rapid intracellular signaling
Kerry Strong Russell, M. Page Haynes, Diviya Sinha, Emmanuelle Clerisme, and Jeffrey R. Bender
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5930–5935.
PMCID: PMC18536
Developmental Biology
Estrogen receptor (ER) β, a modulator of ERα in the uterus
Zhang Weihua, Shigehira Saji, Sirpa Mäkinen, Guojun Cheng, Elwood V. Jensen, Margaret Warner, and Jan-Åke Gustafsson
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5936–5941.
PMCID: PMC18537
The ryanodine receptor is essential for larval development in Drosophila melanogaster
Kathleen M. C. Sullivan, Kristin Scott, Charles S. Zuker, and Gerald M. Rubin
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5942–5947. Published online 2000 May 16.
PMCID: PMC18538
Ecology
Reduced genetic variation and the success of an invasive species
Neil D. Tsutsui, Andrew V. Suarez, David A. Holway, and Ted J. Case
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5948–5953. Published online 2000 May 16.
PMCID: PMC18539
Umbrellas and flagships: Efficient conservation surrogates or expensive mistakes?
Sandy J. Andelman and William F. Fagan
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5954–5959. Published online 2000 May 16.
PMCID: PMC18540
Evolution
Reduced X-linked nucleotide polymorphism in Drosophila simulans
David J. Begun and Penn Whitley
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5960–5965.
PMCID: PMC18541
Genetics
brakeless is required for photoreceptor growth-cone targeting in Drosophila
Yong Rao, Peng Pang, Wenjing Ruan, Dorian Gunning, and S. Lawrence Zipursky
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5966–5971. Published online 2000 May 16.
PMCID: PMC18542
Increased metalloproteinase activity, oxidant production, and emphysema in surfactant protein D gene-inactivated mice
Susan E. Wert, Mitsuhiro Yoshida, Ann Marie LeVine, Machiko Ikegami, Tracy Jones, Gary F. Ross, James H. Fisher, Thomas R. Korfhagen, and Jeffrey A. Whitsett
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5972–5977. Published online 2000 May 9.
PMCID: PMC18543
An efficient recombination system for chromosome engineering in Escherichia coli
Daiguan Yu, Hilary M. Ellis, E-Chiang Lee, Nancy A. Jenkins, Neal G. Copeland, and Donald L. Court
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5978–5983. Published online 2000 May 16.
PMCID: PMC18544
The yeast A kinases differentially regulate iron uptake and respiratory function
Laura S. Robertson, Helen C. Causton, Richard A. Young, and Gerald R. Fink
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5984–5988. Published online 2000 May 16.
PMCID: PMC18545
UvrA and UvrB suppress illegitimate recombination: Synergistic action with RecQ helicase
Katsuhiro Hanada, Mihoko Iwasaki, Sonoe Ihashi, and Hideo Ikeda
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5989–5994. Published online 2000 May 16.
PMCID: PMC18546
A phage integrase directs efficient site-specific integration in human cells
Amy C. Groth, Eric C. Olivares, Bhaskar Thyagarajan, and Michele P. Calos
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5995–6000. Published online 2000 May 9.
PMCID: PMC18547
Pseudoxanthoma elasticum: Mutations in the MRP6 gene encoding a transmembrane ATP-binding cassette (ABC) transporter
Franziska Ringpfeil, Mark G. Lebwohl, Angela M. Christiano, and Jouni Uitto
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6001–6006. Published online 2000 May 16.
PMCID: PMC18548
Immunology
IL-10 is necessary for the expression of airway hyperresponsiveness but not pulmonary inflammation after allergic sensitization
M. J. Mäkelä, A. Kanehiro, L. Borish, A. Dakhama, J. Loader, A. Joetham, Z. Xing, M. Jordana, G. L. Larsen, and E. W. Gelfand
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6007–6012. Published online 2000 May 16.
PMCID: PMC18549
Cholesterol-dependent clustering of IL-2Rα and its colocalization with HLA and CD48 on T lymphoma cells suggest their functional association with lipid rafts
G. Vereb, J. Matkó, G. Vámosi, S. M. Ibrahim, E. Magyar, S. Varga, J. Szöllősi, A. Jenei, R. Gáspár, Jr., T. A. Waldmann, and S. Damjanovich
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6013–6018.
PMCID: PMC18550
Drosophila Thor participates in host immune defense and connects a translational regulator with innate immunity
Alejandro Bernal and Deborah A. Kimbrell
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6019–6024. Published online 2000 May 16.
PMCID: PMC18551
Secreted and membrane attractin result from alternative splicing of the human ATRN gene
W. Tang, T. M. Gunn, D. F. McLaughlin, G. S. Barsh, S. F. Schlossman, and J. S. Duke-Cohan
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6025–6030. Published online 2000 May 16.
PMCID: PMC18552
Highly reduced protection against Streptococcus pneumoniae after deletion of a single heavy chain gene in mouse
Qing-Sheng Mi, Li Zhou, Dan H. Schulze, Randy T. Fischer, Ana Lustig, Louis J. Rezanka, David M. Donovan, Dan L. Longo, and James J. Kenny
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6031–6036. Published online 2000 May 16.
PMCID: PMC18553
Medical Sciences
From the Cover:
Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease
Gary W. Small, Linda M. Ercoli, Daniel H. S. Silverman, S.-C. Huang, Scott Komo, Susan Y. Bookheimer, Helen Lavretsky, Karen Miller, Prabha Siddarth, Natalie L. Rasgon, John C. Mazziotta, Sanjaya Saxena, H. M. Wu, Michael S. Mega, Jeffrey L. Cummings, Ann M. Saunders, Margaret A. Pericak-Vance, Allen D. Roses, Jorge R. Barrio, and Michael E. Phelps
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6037–6042. Published online 2000 May 16.
PMCID: PMC18554
Inflammation in the developing human intestine: A possible pathophysiologic contribution to necrotizing enterocolitis
N. Nanda Nanthakumar, Robert D. Fusunyan, Ian Sanderson, and W. Allan Walker
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6043–6048.
PMCID: PMC18555
High frequency of hypermethylation at the 14-3-3 σ locus leads to gene silencing in breast cancer
Anne T. Ferguson, Ella Evron, Christopher B. Umbricht, Tej K. Pandita, Timothy A. Chan, Heiko Hermeking, Jeffrey R. Marks, Anouk R. Lambers, P. Andrew Futreal, Martha R. Stampfer, and Saraswati Sukumar
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6049–6054. Published online 2000 May 16.
PMCID: PMC18556
NF-κB inhibition causes spontaneous apoptosis in Epstein–Barr virus-transformed lymphoblastoid cells
Ellen D. Cahir-McFarland, David M. Davidson, Stephanie L. Schauer, Jimmy Duong, and Elliott Kieff
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6055–6060. Published online 2000 May 16.
PMCID: PMC18557
From the Cover:
Preventing ventricular fibrillation by flattening cardiac restitution
Alan Garfinkel, Young-Hoon Kim, Olga Voroshilovsky, Zhilin Qu, Jong R. Kil, Moon-Hyoung Lee, Hrayr S. Karagueuzian, James N. Weiss, and Peng-Sheng Chen
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6061–6066. Published online 2000 May 16.
PMCID: PMC18558
Cancer incidences in Europe related to mortalities, and ethnohistoric, genetic, and geographic distances
Robert R. Sokal, Neal L. Oden, Michael S. Rosenberg, and Barbara A. Thomson
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6067–6072.
PMCID: PMC18559
Mimicking dominant negative inhibition of prion replication through structure-based drug design
Véronique Perrier, Andrew C. Wallace, Kiyotoshi Kaneko, Jiri Safar, Stanley B. Prusiner, and Fred E. Cohen
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6073–6078.
PMCID: PMC18560
Oral administration of a corticotropin-releasing hormone receptor antagonist significantly attenuates behavioral, neuroendocrine, and autonomic responses to stress in primates
Kamal E. Habib, Katherine P. Weld, Kenner C. Rice, Judy Pushkas, Maribeth Champoux, Samuel Listwak, Elizabeth L. Webster, Arthur J. Atkinson, Jay Schulkin, Carlo Contoreggi, George P. Chrousos, Samuel M. McCann, Stephen J. Suomi, J. Dee Higley, and Philip W. Gold
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6079–6084.
PMCID: PMC18561
Mutations in the tuberous sclerosis complex gene TSC2 are a cause of sporadic pulmonary lymphangioleiomyomatosis
Thomas Carsillo, Aristotelis Astrinidis, and Elizabeth Petri Henske
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6085–6090.
PMCID: PMC18562
Microbiology
The complete unique long sequence and the overall genomic organization of the GA strain of Marek's disease virus
Lucy F. Lee, Ping Wu, Dexin Sui, Delin Ren, Jeremy Kamil, Hsing Jien Kung, and Richard L. Witter
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6091–6096.
PMCID: PMC18563
From the Cover:
Specific phenotypic restoration of an attenuated virus by knockout of a host resistance gene
David A. Leib, Michael A. Machalek, Bryan R. G. Williams, Robert H. Silverman, and Herbert W. Virgin
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6097–6101. Published online 2000 May 9.
PMCID: PMC18564
Differential activation of a Candida albicans virulence gene family during infection
Peter Staib, Marianne Kretschmar, Thomas Nichterlein, Herbert Hof, and Joachim Morschhäuser
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6102–6107. Published online 2000 May 16.
PMCID: PMC18565
A DNA transfection system for generation of influenza A virus from eight plasmids
Erich Hoffmann, Gabriele Neumann, Yoshihiro Kawaoka, Gerd Hobom, and Robert G. Webster
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6108–6113. Published online 2000 May 9.
PMCID: PMC18566
Squamous epithelial proliferation induced by walleye dermal sarcoma retrovirus cyclin in transgenic mice
Michael D. Lairmore, James R. Stanley, Stacy A. Weber, and Donald L. Holzschu
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6114–6119. Published online 2000 May 16.
PMCID: PMC18567
Neurobiology
Synaptophysin regulates clathrin-independent endocytosis of synaptic vesicles
Christopher Daly, Mutsuyuki Sugimori, Jorge E. Moreira, Edward B. Ziff, and Rodolfo Llinás
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6120–6125.
PMCID: PMC18568
Embryonic stem cells differentiate into oligodendrocytes and myelinate in culture and after spinal cord transplantation
Su Liu, Yun Qu, Todd J. Stewart, Michael J. Howard, Shushovan Chakrabortty, Terrence F. Holekamp, and John W. McDonald
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6126–6131.
PMCID: PMC18569
Altered pain responses in mice lacking α1E subunit of the voltage-dependent Ca2+ channel
Hironao Saegusa, Takashi Kurihara, Shuqin Zong, Osamu Minowa, An-a Kazuno, Wenhua Han, Yoshihiro Matsuda, Hitomi Yamanaka, Makoto Osanai, Tetsuo Noda, and Tsutomu Tanabe
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6132–6137. Published online 2000 May 9.
PMCID: PMC18570
From the Cover:
Presenilin 1 is linked with γ-secretase activity in the detergent solubilized state
Yue-Ming Li, Ming-Tain Lai, Min Xu, Qian Huang, Jillian DiMuzio-Mower, Mohinder K. Sardana, Xiao-Ping Shi, Kuo-Chang Yin, Jules A. Shafer, and Stephen J. Gardell
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6138–6143. Published online 2000 May 9.
PMCID: PMC18571
Classification of fusiform neocortical interneurons based on unsupervised clustering
Bruno Cauli, James T. Porter, Keisuke Tsuzuki, Bertrand Lambolez, Jean Rossier, Brigitte Quenet, and Etienne Audinat
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6144–6149.
PMCID: PMC18572
A syntactic specialization for Broca's area
David Embick, Alec Marantz, Yasushi Miyashita, Wayne O'Neil, and Kuniyoshi L. Sakai
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6150–6154. Published online 2000 May 16.
PMCID: PMC18573
Direct activation of capsaicin receptors by products of lipoxygenases: Endogenous capsaicin-like substances
Sun Wook Hwang, Hawon Cho, Jiyeon Kwak, Soon-Youl Lee, Chang-Joong Kang, Jooyoung Jung, Soohyun Cho, Kyung Hoon Min, Young-Ger Suh, Donghee Kim, and Uhtaek Oh
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6155–6160.
PMCID: PMC18574
Mitochondrial and extramitochondrial apoptotic signaling pathways in cerebrocortical neurons
Samantha L. Budd, Lalitha Tenneti, Timothy Lishnak, and Stuart A. Lipton
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6161–6166. Published online 2000 May 16.
PMCID: PMC18575
Beyond re-membering: Phantom sensations of congenitally absent limbs
Peter Brugger, Spyros S. Kollias, René M. Müri, Gérard Crelier, Marie-Claude Hepp-Reymond, and Marianne Regard
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6167–6172. Published online 2000 May 9.
PMCID: PMC18576
Nonsaturation of AMPA and NMDA receptors at hippocampal synapses
A. Kimberley McAllister and Charles F. Stevens
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6173–6178. Published online 2000 May 16.
PMCID: PMC18577
Neuropeptide Y: A hypothalamic brake restraining the onset of puberty in primates
M. El Majdoubi, A. Sahu, S. Ramaswamy, and T. M. Plant
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6179–6184. Published online 2000 May 16.
PMCID: PMC18578
Opposing effects of protein kinase C and protein kinase A on metabotropic glutamate receptor signaling: Selective desensitization of the inositol trisphosphate/Ca2+ pathway by phosphorylation of the receptor-G protein-coupling domain
Anna Francesconi and Robert M. Duvoisin
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6185–6190.
PMCID: PMC18579
Neuronal correlates of sensory discrimination in the somatosensory cortex
Adrián Hernández, Antonio Zainos, and Ranulfo Romo
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6191–6196. Published online 2000 May 16.
PMCID: PMC18580
The chemokine growth-related gene product β protects rat cerebellar granule cells from apoptotic cell death through α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors
Cristina Limatola, Maria Teresa Ciotti, Delio Mercanti, Fabrizio Vacca, Davide Ragozzino, Aldo Giovannelli, Angela Santoni, Fabrizio Eusebi, and Ricardo Miledi
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6197–6201. Published online 2000 May 16.
PMCID: PMC18581
Pharmacology
Cocaine vaccines: Antibody protection against relapse in a rat model
M. Rocío A. Carrera, Jon A. Ashley, Bin Zhou, Peter Wirsching, George F. Koob, and Kim D. Janda
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6202–6206.
PMCID: PMC18582
Physiology
Oxytocin and its receptors are synthesized in the rat vasculature
Marek Jankowski, Donghao Wang, Fadi Hajjar, Suhayla Mukaddam-Daher, Samuel M. McCann, and Jolanta Gutkowska
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6207–6211. Published online 2000 May 16.
PMCID: PMC18583
Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator
Lan Ko, Guemalli R. Cardona, and William W. Chin
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6212–6217.
PMCID: PMC18584
Plant Biology
Bruchins: Insect-derived plant regulators that stimulate neoplasm formation
Robert P. Doss, James E. Oliver, William M. Proebsting, Sandra W. Potter, SreyReath Kuy, Stephen L. Clement, R. Thomas Williamson, John R. Carney, and E. David DeVilbiss
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6218–6223. Published online 2000 May 16.
PMCID: PMC18585
A calcium-dependent protein kinase can inhibit a calmodulin-stimulated Ca2+ pump (ACA2) located in the endoplasmic reticulum of Arabidopsis
Ildoo Hwang, Heven Sze, and Jeffrey F. Harper
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6224–6229.
PMCID: PMC18586
Social Sciences
Anthropology
Cancer incidences in Europe related to mortalities, and ethnohistoric, genetic, and geographic distances
Robert R. Sokal, Neal L. Oden, Michael S. Rosenberg, and Barbara A. Thomson
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6067–6072.
PMCID: PMC18559
Social Sciences
The multiple-race population of the United States: Issues and estimates
Joshua R. Goldstein and Ann J. Morning
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6230–6235. Published online 2000 May 16.
PMCID: PMC18587
Corrections
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6236. Published online 2000 May 9.
PMCID: PMC55990
Corrects: John D. Sherman. Synthetic zeolites and other microporous oxide molecular sieves. Proc Natl Acad Sci U S A. 1999 March 30; 96(7): 3471–3478.
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6236. Published online 2000 May 9.
PMCID: PMC55991
Corrects: Nobuhiro Kashige, et al. Tyrosine phosphorylation of p62dok by p210bcr-abl inhibits RasGAP activity. Proc Natl Acad Sci U S A. 2000 February 29; 97(5): 2093–2098.
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6237.
PMCID: PMC55992
Corrects: Flaminia Catteruccia, et al. Toward Anopheles transformation: Minos element activity in anopheline cells and embryos. Proc Natl Acad Sci U S A. 2000 February 29; 97(5): 2157–2162.
Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6237. Published online 2000 May 9.
PMCID: PMC55993
Corrects: Heping Yang, et al. Oryza sativa PSK gene encodes a precursor of phytosulfokine-α, a sulfated peptide growth factor found in plants. Proc Natl Acad Sci U S A. 1999 November 9; 96(23): 13560–13565.
Other Issues:  previous | next | latest | archive