| | This journal provides immediate access to some articles. Commentaries The many faces of DNA polymerases: Strategies for mutagenesis and
for mutational avoidance Errol C. Friedberg, William J. Feaver, and Valerie L. Gerlach Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5681–5683. Published online 2000 May 16. PMCID: PMC33986 HSV.com: Maneuvering the internetworks of viral neuropathogenesis
and evasion of the host defense Seng-Lai Tan and Michael G. Katze Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5684–5686. PMCID: PMC33987 New paradigm for drug therapies of cardiac fibrillation Alain Karma Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5687–5689. PMCID: PMC33988 In search of γ-secretase: Presenilin at the cutting edge Dennis J. Selkoe and Michael S. Wolfe Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5690–5692. PMCID: PMC33989 Ecological character displacement and the study of adaptation Jonathan B. Losos Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5693–5695. PMCID: PMC33990 Functional brain imaging to identify affected subjects
genetically at risk for Alzheimer's disease Stanley I. Rapoport Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5696–5698. Published online 2000 May 16. PMCID: PMC33991 Physical Sciences Applied Mathematics Fast methods for the Eikonal and related Hamilton– Jacobi equations on unstructured meshes J. A. Sethian and A. Vladimirsky Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5699–5703. Published online 2000 May 16. PMCID: PMC18495 Chemistry A route to hierarchical materials based on complexes of metallosupramolecular polyelectrolytes and amphiphiles Dirk G. Kurth, Pit Lehmann, and Markus Schütte Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5704–5707. PMCID: PMC18496 Femtosecond linear dichroism of DNA-intercalating chromophores: Solvation and charge separation dynamics of [Ru(phen)2dppz]2+ systems Björn Önfelt, Per Lincoln, Bengt Nordén, J. Spencer Baskin, and Ahmed H. Zewail Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5708–5713. Published online 2000 May 16. PMCID: PMC18497 Computer Sciences High throughput protein fold identification by using experimental constraints derived from intramolecular cross-links and mass spectrometry Malin M. Young, Ning Tang, Judith C. Hempel, Connie M. Oshiro, Eric W. Taylor, Irwin D. Kuntz, Bradford W. Gibson, and Gavin Dollinger Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5802–5806. Published online 2000 May 16. PMCID: PMC18514 Physics What angle-resolved photoemission experiments tell about the microscopic theory for high-temperature superconductors Elihu Abrahams and C. M. Varma Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5714–5716. Published online 2000 May 16. PMCID: PMC18498 Biological Sciences Biochemistry A mammalian germ cell-specific RNA-binding protein interacts with ubiquitously expressed proteins involved in splice site selection David J. Elliott, Cyril F. Bourgeois, Albrecht Klink, James Stévenin, and Howard J. Cooke Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5717–5722. PMCID: PMC18499 Bcl-2 decreases the free Ca2+ concentration within the endoplasmic reticulum Reyhaneh Foyouzi-Youssefi, Serge Arnaudeau, Christoph Borner, William L. Kelley, Jürg Tschopp, Daniel P. Lew, Nicolas Demaurex, and Karl-Heinz Krause Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5723–5728. PMCID: PMC18500 Crystallographic snapshots along a protein-induced DNA-bending pathway Nancy C. Horton and John J. Perona Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5729–5734. Published online 2000 May 9. PMCID: PMC18501 The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny Raheel Shafi, Sai Prasad N. Iyer, Lesley G. Ellies, Niall O'Donnell, Kurt W. Marek, Daniel Chui, Gerald W. Hart, and Jamey D. Marth Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5735–5739. Published online 2000 May 9. PMCID: PMC18502 The tetranucleotide UCAY directs the specific recognition of RNA by the Nova K-homology 3 domain Kirk B. Jensen, Kiran Musunuru, Hal A. Lewis, Stephen K. Burley, and Robert B. Darnell Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5740–5745. Published online 2000 May 16. PMCID: PMC18503 Protein oxidation in response to increased transcriptional or translational errors S. Dukan, A. Farewell, M. Ballesteros, F. Taddei, M. Radman, and T. Nyström Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5746–5749. Published online 2000 May 16. PMCID: PMC18504 Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans Sanjeev H. Satyal, Enrico Schmidt, Kazunori Kitagawa, Neal Sondheimer, Susan Lindquist, James M. Kramer, and Richard I. Morimoto Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5750–5755. Published online 2000 May 16. PMCID: PMC18505 A multipotential β-1,6-N-acetylglucosaminyl-transferase is encoded by bovine herpesvirus type 4 Alain Vanderplasschen, Nicolas Markine-Goriaynoff, Patrick Lomonte, Masami Suzuki, Nobuyoshi Hiraoka, Jiunn-Chern Yeh, Fabrice Bureau, Luc Willems, Etienne Thiry, Minoru Fukuda, and Paul-Pierre Pastoret Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5756–5761. Published online 2000 May 16. PMCID: PMC18506 Specific interaction of CCR5 amino-terminal domain peptides containing sulfotyrosines with HIV-1 envelope glycoprotein gp120 Emmanuel G. Cormier, Marjan Persuh, Daniah A. D. Thompson, Steven W. Lin, Thomas P. Sakmar, William C. Olson, and Tatjana Dragic Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5762–5767. PMCID: PMC18507 Steroid hormones induce HMG1 overexpression and sensitize breast cancer cells to cisplatin and carboplatin Qing He, Cynthia H. Liang, and Stephen J. Lippard Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5768–5772. Published online 2000 May 16. PMCID: PMC18508 Expression profiling of pancreatic β cells: Glucose regulation of secretory and metabolic pathway genes Gene C. Webb, Murtaza S. Akbar, Chongjian Zhao, and Donald F. Steiner Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5773–5778. Published online 2000 May 16. PMCID: PMC18509 A 12(S)-hydroxyeicosatetraenoic acid receptor interacts with steroid receptor coactivator-1 Yuko Kurahashi, Helena Herbertsson, Mats Söderström, Michael G. Rosenfeld, and Sven Hammarström Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5779–5783. PMCID: PMC18510 Structural diversity of self-cleaving ribozymes Jin Tang and Ronald R. Breaker Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5784–5789. PMCID: PMC18511 The major transition state in folding need not involve the immobilization of side chains Rosemary A. Staniforth, Jonathan L. E. Dean, Qi Zhong, Eva Zerovnik, Anthony R. Clarke, and Jonathan P. Waltho Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5790–5795. PMCID: PMC18512 Internal packing of helical membrane proteins Markus Eilers, Srinivasan C. Shekar, Ted Shieh, Steven O. Smith, and Patrick J. Fleming Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5796–5801. PMCID: PMC18513 High throughput protein fold identification by using experimental constraints derived from intramolecular cross-links and mass spectrometry Malin M. Young, Ning Tang, Judith C. Hempel, Connie M. Oshiro, Eric W. Taylor, Irwin D. Kuntz, Bradford W. Gibson, and Gavin Dollinger Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5802–5806. Published online 2000 May 16. PMCID: PMC18514 The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases Joseph Landry, Ann Sutton, Stefan T. Tafrov, Ryan C. Heller, John Stebbins, Lorraine Pillus, and Rolf Sternglanz Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5807–5811. Published online 2000 May 16. PMCID: PMC18515 Effective inhibition of human cytomegalovirus gene expression and
replication by a ribozyme derived from the catalytic RNA subunit of
RNase P from Escherichia coli Phong Trang, Manfred Lee, Edward Nepomuceno, Joe Kim, Hua Zhu, and Fenyong Liu Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5812–5817. Published online 2000 May 16. PMCID: PMC18516 Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties Andre Levchenko, Jehoshua Bruck, and Paul W. Sternberg Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5818–5823. PMCID: PMC18517 Ser67-phosphorylated inhibitor 1 is a potent protein phosphatase 1 inhibitor Ke-xue Huang and Hemant K. Paudel Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5824–5829. Published online 2000 May 16. PMCID: PMC18518 Domain organization and flavin adenine dinucleotide-binding determinants in the aerotaxis signal transducer Aer of Escherichia coli Sergei I. Bibikov, Lindsey A. Barnes, Yakov Gitin, and John S. Parkinson Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5830–5835. Published online 2000 May 16. PMCID: PMC18519 Interactions between heterologous forms of prion protein: Binding, inhibition of conversion, and species barriers Motohiro Horiuchi, Suzette A. Priola, Joëlle Chabry, and Byron Caughey Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5836–5841. Published online 2000 May 16. PMCID: PMC18520 Structure of a two-domain chitotriosidase from Serratia marcescens at 1.9-Å resolution D. M. F. van Aalten, B. Synstad, M. B. Brurberg, E. Hough, B. W. Riise, V. G. H. Eijsink, and R. K. Wierenga Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5842–5847. PMCID: PMC18521 Construction of hybrid peptide synthetases by module and domain fusions Henning D. Mootz, Dirk Schwarzer, and Mohamed A. Marahiel Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5848–5853. Published online 2000 May 16. PMCID: PMC18522 Structure and mechanism of mammalian thioredoxin reductase: The active site is a redox-active selenolthiol/selenenylsulfide formed from the conserved cysteine-selenocysteine sequence Liangwei Zhong, Elias S. J. Arnér, and Arne Holmgren Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5854–5859. Published online 2000 May 9. PMCID: PMC18523 Dynamic interplay between antagonistic pathways controlling the
σ32 level in
Escherichia coli Miyo T. Morita, Masaaki Kanemori, Hideki Yanagi, and Takashi Yura Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5860–5865. Published online 2000 May 9. PMCID: PMC18524 Biophysics An essential intermediate in the folding of dihydrofolate reductase David K. Heidary, John C. O'Neill, Jr., Melinda Roy, and Patricia A. Jennings Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5866–5870. Published online 2000 May 16. PMCID: PMC18525 How native-state topology affects the folding of dihydrofolate reductase and interleukin-1β Cecilia Clementi, Patricia A. Jennings, and José N. Onuchic Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5871–5876. Published online 2000 May 16. PMCID: PMC18526 Reaction coordinates of biomolecular isomerization Peter G. Bolhuis, Christoph Dellago, and David Chandler Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5877–5882. Published online 2000 May 9. PMCID: PMC18527 Calcium triggers an intramolecular association of the C2 domains in synaptotagmin Ricardo A. García, Cameron E. Forde, and Hilary Arnold Godwin Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5883–5888. Published online 2000 May 16. PMCID: PMC18528 Cell Biology Endoplasmic reticulum retention is a common defect associated with tyrosinase-negative albinism Ruth Halaban, Sherri Svedine, Elaine Cheng, Yoel Smicun, Rebecca Aron, and Daniel N. Hebert Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5889–5894. PMCID: PMC18529 Cloning and characterization of the mammalian brain-specific, Mg2+-dependent neutral sphingomyelinase Kay Hofmann, Stefan Tomiuk, Gabriela Wolff, and Wilhelm Stoffel Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5895–5900. PMCID: PMC18530 The ADP ribosylation factor nucleotide exchange factor ARNO promotes β-arrestin release necessary for luteinizing hormone/choriogonadotropin receptor desensitization Sutapa Mukherjee, Vsevolod V. Gurevich, Jonathan C. R. Jones, James E. Casanova, Scott R. Frank, Evelyn T. Maizels, Marie-France Bader, Richard A. Kahn, Krzysztof Palczewski, Klaus Aktories, and Mary Hunzicker-Dunn Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5901–5906. Published online 2000 May 16. PMCID: PMC18531 Nuclear clusterin/XIP8, an x-ray-induced Ku70-binding protein that signals cell death Chin-Rang Yang, Konstantin Leskov, Kelly Hosley-Eberlein, Tracy Criswell, John J. Pink, Timothy J. Kinsella, and David A. Boothman Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5907–5912. PMCID: PMC18532 Separation of presenilin function in amyloid β-peptide generation and endoproteolysis of Notch Luka Kulic, Jochen Walter, Gerd Multhaup, David B. Teplow, Ralf Baumeister, Helmut Romig, Anja Capell, Harald Steiner, and Christian Haass Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5913–5918. Published online 2000 May 16. PMCID: PMC18533 Identification of a human centrosomal calmodulin-binding protein that shares homology with pericentrin Mark R. Flory, Michael J. Moser, Raymond J. Monnat, Jr., and Trisha N. Davis Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5919–5923. PMCID: PMC18534 Ski acts as a co-repressor with Smad2 and Smad3 to regulate the response to type β transforming growth factor Weidong Xu, Konstantina Angelis, David Danielpour, Maher M. Haddad, Oliver Bischof, Judith Campisi, Ed Stavnezer, and Estela E. Medrano Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5924–5929. Published online 2000 May 16. PMCID: PMC18535 Human vascular endothelial cells contain membrane binding sites for estradiol, which mediate rapid intracellular signaling Kerry Strong Russell, M. Page Haynes, Diviya Sinha, Emmanuelle Clerisme, and Jeffrey R. Bender Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5930–5935. PMCID: PMC18536 Developmental Biology Estrogen receptor (ER) β, a modulator of ERα in the uterus Zhang Weihua, Shigehira Saji, Sirpa Mäkinen, Guojun Cheng, Elwood V. Jensen, Margaret Warner, and Jan-Åke Gustafsson Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5936–5941. PMCID: PMC18537 The ryanodine receptor is essential for larval development in Drosophila melanogaster Kathleen M. C. Sullivan, Kristin Scott, Charles S. Zuker, and Gerald M. Rubin Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5942–5947. Published online 2000 May 16. PMCID: PMC18538 Ecology Reduced genetic variation and the success of an invasive species Neil D. Tsutsui, Andrew V. Suarez, David A. Holway, and Ted J. Case Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5948–5953. Published online 2000 May 16. PMCID: PMC18539 Umbrellas and flagships: Efficient conservation surrogates or expensive mistakes? Sandy J. Andelman and William F. Fagan Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5954–5959. Published online 2000 May 16. PMCID: PMC18540 Evolution Reduced X-linked nucleotide polymorphism in Drosophila simulans David J. Begun and Penn Whitley Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5960–5965. PMCID: PMC18541 Genetics brakeless is required for photoreceptor growth-cone targeting in Drosophila Yong Rao, Peng Pang, Wenjing Ruan, Dorian Gunning, and S. Lawrence Zipursky Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5966–5971. Published online 2000 May 16. PMCID: PMC18542 Increased metalloproteinase activity, oxidant production, and emphysema in surfactant protein D gene-inactivated mice Susan E. Wert, Mitsuhiro Yoshida, Ann Marie LeVine, Machiko Ikegami, Tracy Jones, Gary F. Ross, James H. Fisher, Thomas R. Korfhagen, and Jeffrey A. Whitsett Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5972–5977. Published online 2000 May 9. PMCID: PMC18543 An efficient recombination system for chromosome engineering in
Escherichia coli Daiguan Yu, Hilary M. Ellis, E-Chiang Lee, Nancy A. Jenkins, Neal G. Copeland, and Donald L. Court Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5978–5983. Published online 2000 May 16. PMCID: PMC18544 The yeast A kinases differentially regulate iron uptake and respiratory function Laura S. Robertson, Helen C. Causton, Richard A. Young, and Gerald R. Fink Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5984–5988. Published online 2000 May 16. PMCID: PMC18545 UvrA and UvrB suppress illegitimate recombination: Synergistic action with RecQ helicase Katsuhiro Hanada, Mihoko Iwasaki, Sonoe Ihashi, and Hideo Ikeda Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5989–5994. Published online 2000 May 16. PMCID: PMC18546 A phage integrase directs efficient site-specific integration in human cells Amy C. Groth, Eric C. Olivares, Bhaskar Thyagarajan, and Michele P. Calos Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 5995–6000. Published online 2000 May 9. PMCID: PMC18547 Pseudoxanthoma elasticum: Mutations in the MRP6 gene encoding a transmembrane ATP-binding cassette (ABC) transporter Franziska Ringpfeil, Mark G. Lebwohl, Angela M. Christiano, and Jouni Uitto Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6001–6006. Published online 2000 May 16. PMCID: PMC18548 Immunology IL-10 is necessary for the expression of airway hyperresponsiveness but not pulmonary inflammation after allergic sensitization M. J. Mäkelä, A. Kanehiro, L. Borish, A. Dakhama, J. Loader, A. Joetham, Z. Xing, M. Jordana, G. L. Larsen, and E. W. Gelfand Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6007–6012. Published online 2000 May 16. PMCID: PMC18549 Cholesterol-dependent clustering of IL-2Rα and its colocalization with HLA and CD48 on T lymphoma cells suggest their functional association with lipid rafts G. Vereb, J. Matkó, G. Vámosi, S. M. Ibrahim, E. Magyar, S. Varga, J. Szöllősi, A. Jenei, R. Gáspár, Jr., T. A. Waldmann, and S. Damjanovich Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6013–6018. PMCID: PMC18550 Drosophila Thor participates in host immune defense and connects a translational regulator with innate immunity Alejandro Bernal and Deborah A. Kimbrell Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6019–6024. Published online 2000 May 16. PMCID: PMC18551 Secreted and membrane attractin result from alternative splicing of the human ATRN gene W. Tang, T. M. Gunn, D. F. McLaughlin, G. S. Barsh, S. F. Schlossman, and J. S. Duke-Cohan Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6025–6030. Published online 2000 May 16. PMCID: PMC18552 Highly reduced protection against Streptococcus pneumoniae after deletion of a single heavy chain gene in mouse Qing-Sheng Mi, Li Zhou, Dan H. Schulze, Randy T. Fischer, Ana Lustig, Louis J. Rezanka, David M. Donovan, Dan L. Longo, and James J. Kenny Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6031–6036. Published online 2000 May 16. PMCID: PMC18553 Medical Sciences From the Cover: Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease Gary W. Small, Linda M. Ercoli, Daniel H. S. Silverman, S.-C. Huang, Scott Komo, Susan Y. Bookheimer, Helen Lavretsky, Karen Miller, Prabha Siddarth, Natalie L. Rasgon, John C. Mazziotta, Sanjaya Saxena, H. M. Wu, Michael S. Mega, Jeffrey L. Cummings, Ann M. Saunders, Margaret A. Pericak-Vance, Allen D. Roses, Jorge R. Barrio, and Michael E. Phelps Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6037–6042. Published online 2000 May 16. PMCID: PMC18554 Inflammation in the developing human intestine: A possible pathophysiologic contribution to necrotizing enterocolitis N. Nanda Nanthakumar, Robert D. Fusunyan, Ian Sanderson, and W. Allan Walker Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6043–6048. PMCID: PMC18555 High frequency of hypermethylation at the 14-3-3 σ locus leads to gene silencing in breast cancer Anne T. Ferguson, Ella Evron, Christopher B. Umbricht, Tej K. Pandita, Timothy A. Chan, Heiko Hermeking, Jeffrey R. Marks, Anouk R. Lambers, P. Andrew Futreal, Martha R. Stampfer, and Saraswati Sukumar Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6049–6054. Published online 2000 May 16. PMCID: PMC18556 NF-κB inhibition causes spontaneous apoptosis in Epstein–Barr virus-transformed lymphoblastoid cells Ellen D. Cahir-McFarland, David M. Davidson, Stephanie L. Schauer, Jimmy Duong, and Elliott Kieff Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6055–6060. Published online 2000 May 16. PMCID: PMC18557 From the Cover: Preventing ventricular fibrillation by flattening cardiac restitution Alan Garfinkel, Young-Hoon Kim, Olga Voroshilovsky, Zhilin Qu, Jong R. Kil, Moon-Hyoung Lee, Hrayr S. Karagueuzian, James N. Weiss, and Peng-Sheng Chen Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6061–6066. Published online 2000 May 16. PMCID: PMC18558 Cancer incidences in Europe related to mortalities, and ethnohistoric, genetic, and geographic distances Robert R. Sokal, Neal L. Oden, Michael S. Rosenberg, and Barbara A. Thomson Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6067–6072. PMCID: PMC18559 Mimicking dominant negative inhibition of prion replication through structure-based drug design Véronique Perrier, Andrew C. Wallace, Kiyotoshi Kaneko, Jiri Safar, Stanley B. Prusiner, and Fred E. Cohen Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6073–6078. PMCID: PMC18560 Oral administration of a corticotropin-releasing hormone receptor antagonist significantly attenuates behavioral, neuroendocrine, and autonomic responses to stress in primates Kamal E. Habib, Katherine P. Weld, Kenner C. Rice, Judy Pushkas, Maribeth Champoux, Samuel Listwak, Elizabeth L. Webster, Arthur J. Atkinson, Jay Schulkin, Carlo Contoreggi, George P. Chrousos, Samuel M. McCann, Stephen J. Suomi, J. Dee Higley, and Philip W. Gold Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6079–6084. PMCID: PMC18561 Mutations in the tuberous sclerosis complex gene TSC2 are a cause of sporadic pulmonary lymphangioleiomyomatosis Thomas Carsillo, Aristotelis Astrinidis, and Elizabeth Petri Henske Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6085–6090. PMCID: PMC18562 Microbiology The complete unique long sequence and the overall genomic organization of the GA strain of Marek's disease virus Lucy F. Lee, Ping Wu, Dexin Sui, Delin Ren, Jeremy Kamil, Hsing Jien Kung, and Richard L. Witter Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6091–6096. PMCID: PMC18563 From the Cover: Specific phenotypic restoration of an attenuated virus by knockout of a host resistance gene David A. Leib, Michael A. Machalek, Bryan R. G. Williams, Robert H. Silverman, and Herbert W. Virgin Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6097–6101. Published online 2000 May 9. PMCID: PMC18564 Differential activation of a Candida albicans virulence gene family during infection Peter Staib, Marianne Kretschmar, Thomas Nichterlein, Herbert Hof, and Joachim Morschhäuser Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6102–6107. Published online 2000 May 16. PMCID: PMC18565 A DNA transfection system for generation of influenza A virus from eight plasmids Erich Hoffmann, Gabriele Neumann, Yoshihiro Kawaoka, Gerd Hobom, and Robert G. Webster Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6108–6113. Published online 2000 May 9. PMCID: PMC18566 Squamous epithelial proliferation induced by walleye dermal sarcoma retrovirus cyclin in transgenic mice Michael D. Lairmore, James R. Stanley, Stacy A. Weber, and Donald L. Holzschu Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6114–6119. Published online 2000 May 16. PMCID: PMC18567 Neurobiology Synaptophysin regulates clathrin-independent endocytosis of synaptic vesicles Christopher Daly, Mutsuyuki Sugimori, Jorge E. Moreira, Edward B. Ziff, and Rodolfo Llinás Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6120–6125. PMCID: PMC18568 Embryonic stem cells differentiate into oligodendrocytes and myelinate in culture and after spinal cord transplantation Su Liu, Yun Qu, Todd J. Stewart, Michael J. Howard, Shushovan Chakrabortty, Terrence F. Holekamp, and John W. McDonald Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6126–6131. PMCID: PMC18569 Altered pain responses in mice lacking α1E subunit of the voltage-dependent Ca2+ channel Hironao Saegusa, Takashi Kurihara, Shuqin Zong, Osamu Minowa, An-a Kazuno, Wenhua Han, Yoshihiro Matsuda, Hitomi Yamanaka, Makoto Osanai, Tetsuo Noda, and Tsutomu Tanabe Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6132–6137. Published online 2000 May 9. PMCID: PMC18570 From the Cover: Presenilin 1 is linked with γ-secretase activity in the detergent solubilized state Yue-Ming Li, Ming-Tain Lai, Min Xu, Qian Huang, Jillian DiMuzio-Mower, Mohinder K. Sardana, Xiao-Ping Shi, Kuo-Chang Yin, Jules A. Shafer, and Stephen J. Gardell Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6138–6143. Published online 2000 May 9. PMCID: PMC18571 Classification of fusiform neocortical interneurons based on unsupervised clustering Bruno Cauli, James T. Porter, Keisuke Tsuzuki, Bertrand Lambolez, Jean Rossier, Brigitte Quenet, and Etienne Audinat Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6144–6149. PMCID: PMC18572 A syntactic specialization for Broca's area David Embick, Alec Marantz, Yasushi Miyashita, Wayne O'Neil, and Kuniyoshi L. Sakai Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6150–6154. Published online 2000 May 16. PMCID: PMC18573 Direct activation of capsaicin receptors by products of lipoxygenases: Endogenous capsaicin-like substances Sun Wook Hwang, Hawon Cho, Jiyeon Kwak, Soon-Youl Lee, Chang-Joong Kang, Jooyoung Jung, Soohyun Cho, Kyung Hoon Min, Young-Ger Suh, Donghee Kim, and Uhtaek Oh Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6155–6160. PMCID: PMC18574 Mitochondrial and extramitochondrial apoptotic signaling pathways in cerebrocortical neurons Samantha L. Budd, Lalitha Tenneti, Timothy Lishnak, and Stuart A. Lipton Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6161–6166. Published online 2000 May 16. PMCID: PMC18575 Beyond re-membering: Phantom sensations of congenitally absent limbs Peter Brugger, Spyros S. Kollias, René M. Müri, Gérard Crelier, Marie-Claude Hepp-Reymond, and Marianne Regard Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6167–6172. Published online 2000 May 9. PMCID: PMC18576 Nonsaturation of AMPA and NMDA receptors at hippocampal synapses A. Kimberley McAllister and Charles F. Stevens Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6173–6178. Published online 2000 May 16. PMCID: PMC18577 Neuropeptide Y: A hypothalamic brake restraining the onset of puberty in primates M. El Majdoubi, A. Sahu, S. Ramaswamy, and T. M. Plant Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6179–6184. Published online 2000 May 16. PMCID: PMC18578 Opposing effects of protein kinase C and protein kinase A on metabotropic glutamate receptor signaling: Selective desensitization of the inositol trisphosphate/Ca2+ pathway by phosphorylation of the receptor-G protein-coupling domain Anna Francesconi and Robert M. Duvoisin Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6185–6190. PMCID: PMC18579 Neuronal correlates of sensory discrimination in the somatosensory cortex Adrián Hernández, Antonio Zainos, and Ranulfo Romo Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6191–6196. Published online 2000 May 16. PMCID: PMC18580 The chemokine growth-related gene product β protects rat cerebellar granule cells from apoptotic cell death through α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors Cristina Limatola, Maria Teresa Ciotti, Delio Mercanti, Fabrizio Vacca, Davide Ragozzino, Aldo Giovannelli, Angela Santoni, Fabrizio Eusebi, and Ricardo Miledi Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6197–6201. Published online 2000 May 16. PMCID: PMC18581 Pharmacology Cocaine vaccines: Antibody protection against relapse in a rat model M. Rocío A. Carrera, Jon A. Ashley, Bin Zhou, Peter Wirsching, George F. Koob, and Kim D. Janda Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6202–6206. PMCID: PMC18582 Physiology Oxytocin and its receptors are synthesized in the rat vasculature Marek Jankowski, Donghao Wang, Fadi Hajjar, Suhayla Mukaddam-Daher, Samuel M. McCann, and Jolanta Gutkowska Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6207–6211. Published online 2000 May 16. PMCID: PMC18583 Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator Lan Ko, Guemalli R. Cardona, and William W. Chin Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6212–6217. PMCID: PMC18584 Plant Biology Bruchins: Insect-derived plant regulators that stimulate neoplasm formation Robert P. Doss, James E. Oliver, William M. Proebsting, Sandra W. Potter, SreyReath Kuy, Stephen L. Clement, R. Thomas Williamson, John R. Carney, and E. David DeVilbiss Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6218–6223. Published online 2000 May 16. PMCID: PMC18585 A calcium-dependent protein kinase can inhibit a calmodulin-stimulated Ca2+ pump (ACA2) located in the endoplasmic reticulum of Arabidopsis Ildoo Hwang, Heven Sze, and Jeffrey F. Harper Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6224–6229. PMCID: PMC18586 Social Sciences Anthropology Cancer incidences in Europe related to mortalities, and ethnohistoric, genetic, and geographic distances Robert R. Sokal, Neal L. Oden, Michael S. Rosenberg, and Barbara A. Thomson Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6067–6072. PMCID: PMC18559 Social Sciences The multiple-race population of the United States: Issues and estimates Joshua R. Goldstein and Ann J. Morning Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6230–6235. Published online 2000 May 16. PMCID: PMC18587 Corrections Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6236. Published online 2000 May 9. PMCID: PMC55990 Corrects: John D. Sherman. Synthetic zeolites and other microporous oxide molecular sieves. Proc Natl Acad Sci U S A. 1999 March 30; 96(7): 3471–3478. Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6236. Published online 2000 May 9. PMCID: PMC55991 Corrects: Nobuhiro Kashige, et al. Tyrosine phosphorylation of p62dok by p210bcr-abl inhibits RasGAP activity. Proc Natl Acad Sci U S A. 2000 February 29; 97(5): 2093–2098. Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6237. PMCID: PMC55992 Corrects: Flaminia Catteruccia, et al. Toward Anopheles transformation: Minos element activity in anopheline cells and embryos. Proc Natl Acad Sci U S A. 2000 February 29; 97(5): 2157–2162. Proc Natl Acad Sci U S A. 2000 May 23; 97(11): 6237. Published online 2000 May 9. PMCID: PMC55993 Corrects: Heping Yang, et al. Oryza sativa PSK gene encodes a precursor of phytosulfokine-α, a sulfated peptide growth factor found in plants. Proc Natl Acad Sci U S A. 1999 November 9; 96(23): 13560–13565. |