| | This journal provides immediate access to some articles. From the Academy New Members and Foreign Associates Elected to the National
Academy of Sciences on May 2, 2000: 60 New Members Chosen by the Academy PMCID: PMC33985 Commentaries Sortase, a universal target for therapeutic agents against
Gram-positive bacteria? Pascale Cossart and Renaud Jonquières PMCID: PMC33977 Supramolecular complexes in photosynthetic bacteria Paul A. Loach PMCID: PMC33978 Microcolumns in the cerebral cortex Edward G. Jones PMCID: PMC33979 Gene therapy for the hemoglobin disorders: Past, present,
and future Derek A. Persons and Arthur W. Nienhuis PMCID: PMC33980 The making of infectious viral RNA: No size limit in sight Michael M. C. Lai PMCID: PMC33981 Correlation between the structure of the bacterial peptidoglycan
monomer unit, the specificity of transpeptidation, and
susceptibility to β-lactams Jean van Heijenoort and Laurent Gutmann PMCID: PMC33982 Cell signaling pathways as control modules: Complexity for
simplicity? Douglas A. Lauffenburger PMCID: PMC33983 Perspective National security and scientific communication Wolfgang K. H. Panofsky PMCID: PMC33984 Physical Sciences Applied Physical Sciences From the Cover:
Description of microcolumnar ensembles in association cortex and their disruption in Alzheimer and Lewy body dementias S. V. Buldyrev, L. Cruz, T. Gomez-Isla, E. Gomez-Tortosa, S. Havlin, R. Le, H. E. Stanley, B. Urbanc, and B. T. Hyman PMCID: PMC25777 Chemistry Exceptionally potent inhibitors of fatty acid amide hydrolase: The enzyme responsible for degradation of endogenous oleamide and anandamide Dale L. Boger, Haruhiko Sato, Aaron E. Lerner, Michael P. Hedrick, Robert A. Fecik, Hiroshi Miyauchi, Gordon D. Wilkie, Bryce J. Austin, Matthew P. Patricelli, and Benjamin F. Cravatt PMCID: PMC25778 Selective disruption of protein aggregation by cyclodextrin dimers David K. Leung, Zhiwei Yang, and Ronald Breslow PMCID: PMC25779 Engineering Peptide interfacial adsorption is kinetically limited by the thermodynamic stability of self association Anton P. J. Middelberg, Clay J. Radke, and Harvey W. Blanch PMCID: PMC25780 Physics New patterns of centrifugally driven thermal convection M. Jaletzky and F. H. Busse PMCID: PMC25781 Biological Sciences Agricultural Sciences A highly digestible sorghum mutant cultivar exhibits a unique folded structure of endosperm protein bodies Maria P. Oria, Bruce R. Hamaker, John D. Axtell, and Chia-Ping Huang PMCID: PMC25782 Applied Biological Sciences Peptide interfacial adsorption is kinetically limited by the thermodynamic stability of self association Anton P. J. Middelberg, Clay J. Radke, and Harvey W. Blanch PMCID: PMC25780 Blood glutathione synthesis rates in healthy adults receiving a sulfur amino acid-free diet J. Lyons, A. Rauh-Pfeiffer, Y. M. Yu, X.-M. Lu, D. Zurakowski, R. G. Tompkins, A. M. Ajami, V. R. Young, and L. Castillo PMCID: PMC25783 Biochemistry Selective disruption of protein aggregation by cyclodextrin dimers David K. Leung, Zhiwei Yang, and Ronald Breslow PMCID: PMC25779 Binding of bisubstrate analog promotes large structural changes in the unregulated catalytic trimer of aspartate transcarbamoylase: Implications for allosteric regulation James A. Endrizzi, Peter T. Beernink, Tom Alber, and H. K. Schachman PMCID: PMC25784 Uracil-DNA glycosylase–DNA substrate and product structures: Conformational strain promotes catalytic efficiency by coupled stereoelectronic effects Sudip S. Parikh, Gunter Walcher, Garry D. Jones, Geir Slupphaug, Hans E. Krokan, G. Michael Blackburn, and John A. Tainer PMCID: PMC25785 Phosphorylation of protein kinase N by phosphoinositide-dependent protein kinase-1 mediates insulin signals to the actin cytoskeleton Lily Q. Dong, Luis R. Landa, Michael J. Wick, Li Zhu, Hideyuki Mukai, Yoshitaka Ono, and Feng Liu PMCID: PMC25786 DNA polymerase active site is highly mutable: Evolutionary consequences Premal H. Patel and Lawrence A. Loeb PMCID: PMC25787 Glutathione synthesis is essential for mouse development but not for cell growth in culture Zheng-Zheng Shi, Joseph Osei-Frimpong, Geeta Kala, Subbarao V. Kala, Roberto J. Barrios, Geetha M. Habib, Dana J. Lukin, Christopher M. Danney, Martin M. Matzuk, and Michael W. Lieberman PMCID: PMC25788 The crystal structure of the Rev binding element of HIV-1 reveals novel base pairing and conformational variability Li-Wei Hung, Elizabeth L. Holbrook, and Stephen R. Holbrook PMCID: PMC25789 (4-Aminomethyl)phenylguanidine derivatives as nonpeptidic highly selective inhibitors of human urokinase Stefan Sperl, Uwe Jacob, Nuria Arroyo de Prada, Jörg Stürzebecher, Olaf G. Wilhelm, Wolfram Bode, Viktor Magdolen, Robert Huber, and Luis Moroder PMCID: PMC25790 Misactivated amino acids translocate at similar rates across surface of a tRNA synthetase Tyzoon K. Nomanbhoy and Paul R. Schimmel PMCID: PMC25791 Asparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by Site-2 protease Jin Ye, Utpal P. Davé, Nick V. Grishin, Joseph L. Goldstein, and Michael S. Brown PMCID: PMC25792 Assembly of τ protein into Alzheimer paired helical filaments depends on a local sequence motif (306VQIVYK311) forming β structure M. von Bergen, P. Friedhoff, J. Biernat, J. Heberle, E.-M. Mandelkow, and E. Mandelkow PMCID: PMC25793 5-Methylcytosine-DNA glycosylase activity is present in a cloned G/T mismatch DNA glycosylase associated with the chicken embryo DNA demethylation complex Bing Zhu, Yong Zheng, Daniel Hess, Herbert Angliker, Steffen Schwarz, Michel Siegmann, Stéphane Thiry, and Jean-Pierre Jost PMCID: PMC25794 Bepridil opens the regulatory N-terminal lobe of cardiac troponin C Yu Li, Michael L. Love, John A. Putkey, and Carolyn Cohen PMCID: PMC25795 Direct nitric oxide signal transduction via nitrosylation of iron-sulfur centers in the SoxR transcription activator Huangen Ding and Bruce Demple PMCID: PMC25796 Noninvasive measurement of gene expression in skeletal muscle Glenn Walter, Elisabeth R. Barton, and H. Lee Sweeney PMCID: PMC25797 Conversion of a c type cytochrome to a b type that spontaneously forms in vitro from apo protein and heme: Implications for c type cytochrome biogenesis and folding Esther J. Tomlinson and Stuart J. Ferguson PMCID: PMC25798 Estimating the probability for a protein to have a new fold: A statistical computational model Elon Portugaly and Michal Linial PMCID: PMC25799 Characterization of PDZ-binding kinase, a mitotic kinase Suzanne Gaudet, Daniel Branton, and Robert A. Lue PMCID: PMC25800 The Gcd10p/Gcd14p complex is the essential two-subunit
tRNA(1-methyladenosine) methyltransferase of
Saccharomyces cerevisiae James Anderson, Lon Phan, and Alan G. Hinnebusch PMCID: PMC25801 Biophysics Single-molecule protein folding: Diffusion fluorescence resonance energy transfer studies of the denaturation of chymotrypsin inhibitor 2 Ashok A. Deniz, Ted A. Laurence, Gangamani S. Beligere, Maxime Dahan, Andrew B. Martin, Daniel S. Chemla, Philip E. Dawson, Peter G. Schultz, and Shimon Weiss PMCID: PMC25802 Detection and selective dissociation of intact ribosomes in a mass spectrometer Adam A. Rostom, Paola Fucini, Dennis R. Benjamin, Ralf Juenemann, Knud H. Nierhaus, F. Ulrich Hartl, Christopher M. Dobson, and Carol V. Robinson PMCID: PMC25803 Mapping the interface between calmodulin and MARCKS-related protein by fluorescence spectroscopy Andreas Ulrich, Arndt A. P. Schmitz, Thomas Braun, Tao Yuan, Hans J. Vogel, and Guy Vergères PMCID: PMC25804 From the Cover:
The long-range supraorganization of the bacterial photosynthetic unit: A key role for PufX Raoul N. Frese, John D. Olsen, Rikard Branvall, Willem H. J. Westerhuis, C. Neil Hunter, and Rienk van Grondelle PMCID: PMC25805 Separation of the glucose-stimulated cytoplasmic and mitochondrial NAD(P)H responses in pancreatic islet β cells George H. Patterson, Susan M. Knobel, Per Arkhammar, Ole Thastrup, and David W. Piston PMCID: PMC25806 Cell Biology Collaboration of signal transducer and activator of transcription 1 (STAT1) and BRCA1 in differential regulation of IFN-γ target genes Toru Ouchi, Sam W. Lee, Mutsuko Ouchi, Stuart A. Aaronson, and Curt M. Horvath PMCID: PMC25807 Nuclear structure in normal and Bloom syndrome cells Victor Yankiwski, Robert A. Marciniak, Leonard Guarente, and Norma F. Neff PMCID: PMC25808 A green fluorescent protein-reporter mammalian two-hybrid system with extrachromosomal maintenance of a prey expression plasmid: Application to interaction screening Toshi Shioda, Stephanie Andriole, Tetsuro Yahata, and Kurt J. Isselbacher PMCID: PMC25809 Role of Rac in controlling the actin cytoskeleton and chemotaxis in motile cells Chang Y. Chung, Susan Lee, Celia Briscoe, Charlene Ellsworth, and Richard A. Firtel PMCID: PMC25810 NMR and mutagenesis evidence for an I domain allosteric site that regulates lymphocyte function-associated antigen 1 ligand binding Jeffrey R. Huth, Edward T. Olejniczak, Renaldo Mendoza, Heng Liang, Edith A. S. Harris, Mark L. Lupher, Jr., Amy E. Wilson, Stephen W. Fesik, and Donald E. Staunton PMCID: PMC25811 Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a Bernard H. Ramsahoye, Detlev Biniszkiewicz, Frank Lyko, Victoria Clark, Adrian P. Bird, and Rudolf Jaenisch PMCID: PMC25812 MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration Ying Xia, Constantin Makris, Bing Su, Erguang Li, Jianhua Yang, Glen R. Nemerow, and Michael Karin PMCID: PMC25813 Sid4p is required to localize components of the septation initiation pathway to the spindle pole body in fission yeast Louise Chang and Kathleen L. Gould PMCID: PMC25814 Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa Eric Camerer, Wei Huang, and Shaun R. Coughlin PMCID: PMC25815 5-Lipoxygenase is phosphorylated by p38 kinase-dependent MAPKAP kinases Oliver Werz, Jenny Klemm, Bengt Samuelsson, and Olof Rådmark PMCID: PMC25816 Distinct roles of the NH2- and COOH-terminal domains of the protein inhibitor of activated signal transducer and activator of transcription (STAT) 1 (PIAS1) in cytokine-induced PIAS1–Stat1 interaction Jiayu Liao, Yubin Fu, and Ke Shuai PMCID: PMC25817 The myosin motor, Myo4p, binds Ash1 mRNA via the adapter protein, She3p Peter A. Takizawa and Ronald D. Vale PMCID: PMC25818 Developmental Biology Increased IGF-II protein affects p57kip2 expression in vivo and in vitro: Implications for Beckwith–Wiedemann syndrome Valérie Grandjean, Janet Smith, Paul N. Schofield, and Anne C. Ferguson-Smith PMCID: PMC25819 Somatic polyploidization and cellular proliferation drive body size evolution in nematodes Anthony J. Flemming, Zai-Zhong Shen, Ana Cunha, Scott W. Emmons, and Armand M. Leroi PMCID: PMC25820 Xenopus Kielin: A dorsalizing factor containing multiple chordin-type repeats secreted from the embryonic midline Masaru Matsui, Kenji Mizuseki, Jin Nakatani, Shigetada Nakanishi, and Yoshiki Sasai PMCID: PMC25821 Ecology Rapid transition in the structure of a coral reef community: The effects of coral bleaching and physical disturbance Gary K. Ostrander, Kelley Meyer Armstrong, Edward T. Knobbe, Donald Gerace, and Erik P. Scully PMCID: PMC25822 Density-dependent decline of host abundance resulting from a new infectious disease Wesley M. Hochachka and André A. Dhondt PMCID: PMC25823 Evolution Novel gene conversion between X-Y homologues located in the nonrecombining region of the Y chromosome in Felidae (Mammalia) Jill Pecon Slattery, Leslie Sanner-Wachter, and Stephen J. O'Brien PMCID: PMC25824 The phylogeny of closely related species as revealed by the genealogy of a speciation gene, Odysseus Chau-Ti Ting, Shun-Chern Tsaur, and Chung-I Wu PMCID: PMC25825 INAUGURAL ARTICLE by a Recently Elected Academy Member: Permanence or change? The meaning of genetic variation Francisco M. Salzano PMCID: PMC25826 Rapid evolution in plant chitinases: Molecular targets of selection in plant-pathogen coevolution J. G. Bishop, A. M. Dean, and T. Mitchell-Olds PMCID: PMC25827 An ancestral MADS-box gene duplication occurred before the divergence of plants and animals Elena R. Alvarez-Buylla, Soraya Pelaz, Sarah J. Liljegren, Scott E. Gold, Caroline Burgeff, Gary S. Ditta, Lluis Ribas de Pouplana, León Martínez-Castilla, and Martin F. Yanofsky PMCID: PMC25828 Gene content phylogeny of herpesviruses Michael G. Montague and Clyde A. Hutchison, III PMCID: PMC25829 Genetics The fourth chromosome of Drosophila melanogaster: Interspersed euchromatic and heterochromatic domains Fang-Lin Sun, Matthew H. Cuaycong, Carolyn A. Craig, Lori L. Wallrath, John Locke, and Sarah C. R. Elgin PMCID: PMC25830 Behavioral alterations associated with apoptosis and down-regulation of presenilin 1 in the brains of p53-deficient mice Robert Amson, Jean-Michel Lassalle, Hélène Halley, Sylvie Prieur, Florence Lethrosne, Jean-Pierre Roperch, David Israeli, Marie-Claude Gendron, Charles Duyckaerts, Frédéric Checler, Jean Dausset, Daniel Cohen, Moshe Oren, and Adam Telerman PMCID: PMC25831 LexA chimeras reveal the function of Drosophila Fos as a context-dependent transcriptional activator David Szüts and Mariann Bienz PMCID: PMC25832 Chromosomal breakage-fusion-bridge events cause genetic intratumor heterogeneity David Gisselsson, Louise Pettersson, Mattias Höglund, Markus Heidenblad, Ludmila Gorunova, Joop Wiegant, Fredrik Mertens, Paola Dal Cin, Felix Mitelman, and Nils Mandahl PMCID: PMC25833 Rescue of dystrophin expression in mdx mouse muscle by RNA/DNA oligonucleotides Thomas A. Rando, Marie-Helene Disatnik, and Lucy Z.-H. Zhou PMCID: PMC25834 Automated parallel DNA sequencing on multiple channel microchips Shaorong Liu, Hongji Ren, Qiufeng Gao, David J. Roach, Robert T. Loder, Jr., Thomas M. Armstrong, Qinglu Mao, Iuliu Blaga, David L. Barker, and Stevan B. Jovanovich PMCID: PMC25835 Computation, prediction, and experimental tests of fitness for bacteriophage T7 mutants with permuted genomes Drew Endy, Lingchong You, John Yin, and Ian J. Molineux PMCID: PMC25836 Inverse radiation dose-rate effects on somatic and germ-line mutations and DNA damage rates Michael M. Vilenchik and Alfred G. Knudson, Jr. PMCID: PMC25837 Immunology In vitro evolution of a T cell receptor with high affinity for peptide/MHC Phillip D. Holler, Philmore O. Holman, Eric V. Shusta, Sean O'Herrin, K. Dane Wittrup, and David M. Kranz PMCID: PMC25838 Long-term kinetics of T cell production in HIV-infected subjects treated with highly active antiretroviral therapy S. Fleury, G. P. Rizzardi, A. Chapuis, G. Tambussi, C. Knabenhans, E. Simeoni, J.-Y. Meuwly, J.-M. Corpataux, A. Lazzarin, F. Miedema, and G. Pantaleo PMCID: PMC25839 Crystal structure of a Staphylococcus aureus protein A domain complexed with the Fab fragment of a human IgM antibody: Structural basis for recognition of B-cell receptors and superantigen activity Marc Graille, Enrico A. Stura, Adam L. Corper, Brian J. Sutton, Michael J. Taussig, Jean-Baptiste Charbonnier, and Gregg J. Silverman PMCID: PMC25840 Signals transducers and activators of transcription (STAT)-induced STAT inhibitor-1 (SSI-1)/suppressor of cytokine signaling-1 (SOCS-1) suppresses tumor necrosis factor α-induced cell death in fibroblasts Yoshiaki Morita, Tetsuji Naka, Yoshinori Kawazoe, Minoru Fujimoto, Masashi Narazaki, Reiko Nakagawa, Hidehiro Fukuyama, Shigekazu Nagata, and Tadamitsu Kishimoto PMCID: PMC25841 Medical Sciences From the Cover:
Preselection of retrovirally transduced bone marrow avoids subsequent stem cell gene silencing and age-dependent extinction of expression of human β-globin in engrafted mice Christian P. Kalberer, Robert Pawliuk, Suzan Imren, Thomas Bachelot, Ken J. Takekoshi, Mary Fabry, Connie J. Eaves, Irving M. London, R. Keith Humphries, and Philippe Leboulch PMCID: PMC25842 Myogenic stem cell function is impaired in mice lacking the forkhead/winged helix protein MNF Daniel J. Garry, Annette Meeson, Joel Elterman, Yuhe Zhao, Peng Yang, Rhonda Bassel-Duby, and R. Sanders Williams PMCID: PMC25843 Epithelial and endothelial expression of the green fluorescent protein reporter gene under the control of bovine prion protein (PrP) gene regulatory sequences in transgenic mice Catherine Lemaire-Vieille, Tobias Schulze, Valérie Podevin-Dimster, Jérome Follet, Yannick Bailly, Françoise Blanquet-Grossard, Jean-Pierre Decavel, Ernst Heinen, and Jean-Yves Cesbron PMCID: PMC25844 Preservation of myocardial β-adrenergic receptor signaling delays the development of heart failure after myocardial infarction David C. White, Jonathan A. Hata, Ashish S. Shah, Donald D. Glower, Robert J. Lefkowitz, and Walter J. Koch PMCID: PMC25845 Uncompensated polyuria in a mouse model of Bartter's syndrome Nobuyuki Takahashi, Daniel R. Chernavvsky, R. Ariel Gomez, Peter Igarashi, Hillel J. Gitelman, and Oliver Smithies PMCID: PMC25846 d-β-Hydroxybutyrate protects neurons in models of Alzheimer's and Parkinson's disease Yoshihiro Kashiwaya, Takao Takeshima, Nozomi Mori, Kenji Nakashima, Kieran Clarke, and Richard L. Veech PMCID: PMC25847 Gain of imprinting at chromosome 11p15: A pathogenetic mechanism identified in human hepatocarcinomas Christine Schwienbacher, Laura Gramantieri, Rosaria Scelfo, Angelo Veronese, George A. Calin, Luigi Bolondi, Carlo M. Croce, Giuseppe Barbanti-Brodano, and Massimo Negrini PMCID: PMC25848 Molecular basis for a link between complement and the vascular complications of diabetes Juan Acosta, Judith Hettinga, Rudolf Flückiger, Nicole Krumrei, Allison Goldfine, Luis Angarita, and Jose Halperin PMCID: PMC25849 Endogenous tumor necrosis factor protects the adult cardiac myocyte against ischemic-induced apoptosis in a murine model of acute myocardial infarction Karla M. Kurrelmeyer, Lloyd H. Michael, Georg Baumgarten, George E. Taffet, Jacques J. Peschon, Natarajan Sivasubramanian, Mark L. Entman, and Douglas L. Mann PMCID: PMC25850 AIS is an oncogene amplified in squamous cell carcinoma Kenji Hibi, Barry Trink, Meera Patturajan, William H. Westra, Otávia L. Caballero, David E. Hill, Edward A. Ratovitski, Jin Jen, and David Sidransky PMCID: PMC25851 Ultrasensitive detection of pathological prion protein aggregates by dual-color scanning for intensely fluorescent targets J. Bieschke, A. Giese, W. Schulz-Schaeffer, I. Zerr, S. Poser, M. Eigen, and H. Kretzschmar PMCID: PMC25852 Estrogen receptor specificity in the regulation of skeletal growth and maturation in male mice Olle Vidal, Marie K. Lindberg, Karin Hollberg, David J. Baylink, Göran Andersson, Dennis B. Lubahn, Subburaman Mohan, Jan-Åke Gustafsson, and Claes Ohlsson PMCID: PMC25853 Nitric oxide inhibits tumor necrosis factor-α-induced apoptosis by reducing the generation of ceramide Céline De Nadai, Piero Sestili, Orazio Cantoni, Jean-Philippe Lièvremont, Clara Sciorati, Rico Barsacchi, Salvador Moncada, Jacopo Meldolesi, and Emilio Clementi PMCID: PMC25854 c-Abl is required for development and optimal cell proliferation in the context of p53 deficiency Young E. Whang, Chris Tran, Cailin Henderson, Randi G. Syljuasen, Nora Rozengurt, William H. McBride, and Charles L. Sawyers PMCID: PMC25855 An autologous oral DNA vaccine protects against murine melanoma Rong Xiang, Holger N. Lode, Ta-Hsiang Chao, J. Michael Ruehlmann, Carrie S. Dolman, Fernando Rodriguez, J. Lindsay Whitton, Willem W. Overwijk, Nicholas P. Restifo, and Ralph A. Reisfeld PMCID: PMC25856 Critical contribution of liver natural killer T cells to a murine model of hepatitis Kazuyoshi Takeda, Yoshihiro Hayakawa, Luc Van Kaer, Hironori Matsuda, Hideo Yagita, and Ko Okumura PMCID: PMC25857 Aberrant B cell receptor signaling from B29 (Igβ, CD79b) gene mutations of chronic lymphocytic leukemia B cells Melinda S. Gordon, Roberta M. Kato, Frederick Lansigan, Alexis A. Thompson, Randolph Wall, and David J. Rawlings PMCID: PMC25858 Microbiology From the Cover:
Staphylococcus aureus sortase mutants defective in the display of surface proteins and in the pathogenesis of animal infections Sarkis K. Mazmanian, Gwen Liu, Eric R. Jensen, Eileen Lenoy, and Olaf Schneewind PMCID: PMC25859 From the Cover:
Engineering the largest RNA virus genome as an infectious bacterial artificial chromosome Fernando Almazán, José M. González, Zoltan Pénzes, Ander Izeta, Enrique Calvo, Juan Plana-Durán, and Luis Enjuanes PMCID: PMC25860 Cyclin A activates the DNA polymerase δ-dependent elongation machinery in vitro: A parvovirus DNA replication model Tarig Bashir, Rita Hörlein, Jean Rommelaere, and Kurt Willwand PMCID: PMC25861 The Escherichia coli MG1655 in silico metabolic genotype: Its definition, characteristics, and capabilities J. S. Edwards and B. O. Palsson PMCID: PMC25862 Production of infectious bovine papillomavirus from cloned viral DNA by using an organotypic raft/xenograft technique Alison A. McBride, Andrzej Dlugosz, and Carl C. Baker PMCID: PMC25863 Neurobiology Neonatal lead exposure impairs development of rodent barrel field cortex Mary Ann Wilson, Michael V. Johnston, Gary W. Goldstein, and Mary E. Blue PMCID: PMC25864 Growth of new brainstem connections in adult monkeys with massive sensory loss Neeraj Jain, Sherre L. Florence, Hui-Xin Qi, and Jon H. Kaas PMCID: PMC25865 A deletion in a photoreceptor-specific nuclear receptor mRNA causes retinal degeneration in the rd7 mouse Novrouz B. Akhmedov, Natik I. Piriev, Bo Chang, Ana Lia Rapoport, Norman L. Hawes, Patsy M. Nishina, Steven Nusinowitz, John R. Heckenlively, Thomas H. Roderick, Christine A. Kozak, Michael Danciger, Muriel T. Davisson, and Debora B. Farber PMCID: PMC25866 Noise in neurons is message dependent Guillermo A. Cecchi, Mariano Sigman, José-Manuel Alonso, Luis Martínez, Dante R. Chialvo, and Marcelo O. Magnasco PMCID: PMC25867 A neuronal β subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin Pratap Meera, Martin Wallner, and Ligia Toro PMCID: PMC25868 Coexistence of linear zones and pinwheels within orientation maps in cat visual cortex Amir Shmuel and Amiram Grinvald PMCID: PMC25869 Accumulation of protease-resistant prion protein (PrP) and apoptosis of cerebellar granule cells in transgenic mice expressing a PrP insertional mutation Roberto Chiesa, Bettina Drisaldi, Elena Quaglio, Antonio Migheli, Pedro Piccardo, Bernardino Ghetti, and David A. Harris PMCID: PMC25870 Cortical cell death induced by IL-1 is mediated via actions in the hypothalamus of the rat Stuart M. Allan, Lisa C. Parker, Barry Collins, Ralph Davies, Giamal N. Luheshi, and Nancy J. Rothwell PMCID: PMC25871 Establishment and persistence of photoperiodic memory in hamsters Brian J. Prendergast, Michael R. Gorman, and Irving Zucker PMCID: PMC25872 Why are angles misperceived? Surajit Nundy, Beau Lotto, David Coppola, Amita Shimpi, and Dale Purves PMCID: PMC25873 Deficits in memory and motor performance in synaptotagmin IV mutant mice Gregory D. Ferguson, Stephan G. Anagnostaras, Alcino J. Silva, and Harvey R. Herschman PMCID: PMC25874 Inhibition of calcium/calmodulin kinase II alpha subunit expression results in epileptiform activity in cultured hippocampal neurons Severn B. Churn, Sompong Sombati, Emma R. Jakoi, Lawrence Sievert, and Robert J. DeLorenzo PMCID: PMC25875 Acute decrease in net glutamate uptake during energy deprivation Denis Jabaudon, Massimo Scanziani, Beat H. Gähwiler, and Urs Gerber PMCID: PMC25876 Sodium channel Nav1.6 is localized at nodes of Ranvier, dendrites, and synapses John H. Caldwell, Kristin L. Schaller, Robert S. Lasher, Elior Peles, and S. Rock Levinson PMCID: PMC25877 A universal scaling law between gray matter and white matter of cerebral cortex Kechen Zhang and Terrence J. Sejnowski PMCID: PMC25878 Rapid regulated dense-core vesicle exocytosis requires the CAPS protein M. Rupnik, M. Kreft, S. K. Sikdar, S. Grilc, R. Romih, G. Zupan  i , T. F. J. Martin, and R. Zorec PMCID: PMC25879 Pharmacology Potent and nontoxic antisense oligonucleotides containing locked nucleic acids Claes Wahlestedt, Peter Salmi, Liam Good, Johanna Kela, Thomas Johnsson, Tomas Hökfelt, Christian Broberger, Frank Porreca, Josephine Lai, Kunkun Ren, Michael Ossipov, Alexei Koshkin, Nana Jakobsen, Jan Skouv, Henrik Oerum, Mogens Havsteen Jacobsen, and Jesper Wengel PMCID: PMC25880 A binding pocket for a small molecule inhibitor of HIV-1 entry within the transmembrane helices of CCR5 Tatjana Dragic, Alexandra Trkola, Daniah A. D. Thompson, Emmanuel G. Cormier, Francis A. Kajumo, Elizabeth Maxwell, Steven W. Lin, Weiwen Ying, Steven O. Smith, Thomas P. Sakmar, and John P. Moore PMCID: PMC25881 Physiology Early-life exposure to endotoxin alters hypothalamic–pituitary–adrenal function and predisposition to inflammation Nola Shanks, Richard J. Windle, Paula A. Perks, Michael S. Harbuz, David S. Jessop, Colin D. Ingram, and Stafford L. Lightman PMCID: PMC25882 The role of members of the pertussis toxin-sensitive family of G proteins in coupling receptors to the activation of the G protein-gated inwardly rectifying potassium channel Joanne Louise Leaney and Andrew Tinker PMCID: PMC25883 A functional R domain from cystic fibrosis transmembrane conductance regulator is predominantly unstructured in solution Lynda S. Ostedgaard, Olafur Baldursson, Daniel W. Vermeer, Michael J. Welsh, and Andrew D. Robertson PMCID: PMC25884 Plant Biology The tomato ethylene receptors NR and LeETR4 are negative regulators of ethylene response and exhibit functional compensation within a multigene family Denise M. Tieman, Mark G. Taylor, Joseph A. Ciardi, and Harry J. Klee PMCID: PMC25885 Postgerminative growth and lipid catabolism in oilseeds lacking the glyoxylate cycle Peter J. Eastmond, Veronique Germain, Peter R. Lange, James H. Bryce, Steven M. Smith, and Ian A. Graham PMCID: PMC25886 Social Sciences Economic Sciences Nas–Walras equilibria of a large economy E. Minelli and H. M. Polemarchakis PMCID: PMC25887 Corrections Proc Natl Acad Sci U S A. 2000 May 9; 97(10): 5679. Published online 2000 April 25. PMCID: PMC55987 Corrects: Min Liu, et al. Loss of BETA2/NeuroD leads to malformation of the dentate gyrus and epilepsy. Proc Natl Acad Sci U S A. 2000 January 18; 97(2): 865–870. Proc Natl Acad Sci U S A. 2000 May 9; 97(10): 5679. Published online 2000 April 25. PMCID: PMC55988 Corrects: Sazuku Nisitani, et al. Posttranscriptional regulation of Bruton's tyrosine kinase
expression in antigen receptor-stimulated splenic B cells. Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2737–2742. Proc Natl Acad Sci U S A. 2000 May 9; 97(10): 5679. Published online 2000 May 2. PMCID: PMC55989 Corrects: Mohammad Asif, et al. An advanced glycation endproduct cross-link breaker can reverse
age-related increases in myocardial stiffness. Proc Natl Acad Sci U S A. 2000 March 14; 97(6): 2809–2813. |
