| | This journal provides immediate access to some articles. Editorial Redesign of PNAS: Getting ready for the millennium Diane M. Sullenberger, Kenneth R. Fulton, and Nicholas R. Cozzarelli PMCID: PMC33786 Commentaries Chain entropy: Spoiler or benefactor in pattern recognition? M. Muthukumar PMCID: PMC33788 Double-stranded RNA-activated protein kinase mediates
virus-induced apoptosis: A new role for an old actor Randal J. Kaufman PMCID: PMC33789 An advance in liver-specific gene delivery Don Ganem PMCID: PMC33791 Gō-ing for the prediction of protein
folding mechanisms Shoji Takada PMCID: PMC33792 Physical Sciences Applied Physical Sciences Segregation-driven organization in chaotic granular flows K. M. Hill, D. V. Khakhar, J. F. Gilchrist, J. J. McCarthy, and J. M. Ottino PMCID: PMC18349 Chemistry Simulation of biomimetic recognition between polymers and surfaces Aaron J. Golumbfskie, Vijay S. Pande, and Arup K. Chakraborty PMCID: PMC18350 Long-range charge hopping in DNA M. Bixon, Bernd Giese, Stephan Wessely, Thomas Langenbacher, Maria E. Michel-Beyerle, and Joshua Jortner PMCID: PMC18351 Peroxynitrite reaction products of 3′,5′-di-O-acetyl-8-oxo-7,8-dihydro-2′-deoxyguanosine Jacquin C. Niles, Samar Burney, Sukhjeet P. Singh, John S. Wishnok, and Steven R. Tannenbaum PMCID: PMC18354 Biological Sciences Biochemistry Crystal structure of the DNA nucleotide excision repair enzyme UvrB from Thermus thermophilus Mischa Machius, Lisa Henry, Maya Palnitkar, and Johann Deisenhofer PMCID: PMC18352 Selection of antibodies for intracellular function using a two-hybrid in vivo system Michela Visintin, Eric Tse, Hakan Axelson, Terence H. Rabbitts, and Antonino Cattaneo PMCID: PMC18353 Peroxynitrite reaction products of 3′,5′-di-O-acetyl-8-oxo-7,8-dihydro-2′-deoxyguanosine Jacquin C. Niles, Samar Burney, Sukhjeet P. Singh, John S. Wishnok, and Steven R. Tannenbaum PMCID: PMC18354 DNA specificity enhanced by sequential binding of protein monomers Jennifer J. Kohler, Steven J. Metallo, Tanya L. Schneider, and Alanna Schepartz PMCID: PMC18355 A multiplasmid approach to preparing large libraries of polyketides Qun Xue, Gary Ashley, C. Richard Hutchinson, and Daniel V. Santi PMCID: PMC18356 Salt-induced detour through compact regions of the protein folding landscape Daniel E. Otzen and Mikael Oliveberg PMCID: PMC18357 An internal targeting signal directing proteins into the mitochondrial intermembrane space Kerstin Diekert, Gyula Kispal, Bernard Guiard, and Roland Lill PMCID: PMC18358 Cytidine 5′-triphosphate-dependent biosynthesis of isoprenoids: YgbP protein of Escherichia coli catalyzes the formation of 4-diphosphocytidyl-2-C-methylerythritol Felix Rohdich, Juraithip Wungsintaweekul, Monika Fellermeier, Silvia Sagner, Stefan Herz, Klaus Kis, Wolfgang Eisenreich, Adelbert Bacher, and Meinhart H. Zenk PMCID: PMC18359 Correlation of deformability at a tRNA recognition site and aminoacylation specificity Kung-Yao Chang, Gabriele Varani, Subhra Bhattacharya, Hyunsic Choi, and William H. McClain PMCID: PMC18360 Two distinct mechanisms drive protein translocation across the mitochondrial outer membrane in the late step of the cytochrome b2 import pathway Masatoshi Esaki, Takashi Kanamori, Shuh-ichi Nishikawa, and Toshiya Endo PMCID: PMC18361 Glucocorticoid receptor inhibits transforming growth factor-β signaling by directly targeting the transcriptional activation function of Smad3 Chao-Zhong Song, Xin Tian, and Thomas D. Gelehrter PMCID: PMC18362 Nonstatistical binding of a protein to clustered carbohydrates Nina Horan, Lin Yan, Hiroyuki Isobe, George M. Whitesides, and Daniel Kahne PMCID: PMC18363 Active-site structure of the soluble quinoprotein glucose dehydrogenase complexed with methylhydrazine: A covalent cofactor-inhibitor complex Arthur Oubrie, Henriëtte J. Rozeboom, and Bauke W. Dijkstra PMCID: PMC18364 C-terminal DNA binding stimulates N-terminal phosphorylation of the outer membrane protein regulator OmpR from Escherichia coli Sharla K. Ames, Nanja Frankema, and Linda J. Kenney PMCID: PMC18365 In vitro synthesis of the nucleotide loop of cobalamin by Salmonella typhimurium enzymes Lori A. Maggio-Hall and Jorge C. Escalante-Semerena PMCID: PMC18366 Double duplex invasion by peptide nucleic acid: A general principle for sequence-specific targeting of double-stranded DNA Jesper Lohse, Otto Dahl, and Peter E. Nielsen PMCID: PMC18367 A structural snapshot of base-pair opening in DNA Daan M. F. van Aalten, Daniel A. Erlanson, Gregory L. Verdine, and Leemor Joshua-Tor PMCID: PMC18368 Interactions of Gh/transglutaminase with phospholipase Cδ1 and with GTP S. N. Prasanna Murthy, Jon W. Lomasney, Eric C. Mak, and Laszlo Lorand PMCID: PMC18369 Biophysics Direct molecular force measurements of multiple adhesive interactions between cadherin ectodomains S. Sivasankar, W. Brieher, N. Lavrik, B. Gumbiner, and D. Leckband PMCID: PMC18370 A model of the detection of warmth and cold by cutaneous sensors through effects on voltage-gated membrane channels Robert K. Adair PMCID: PMC18371 Cell Biology Role of the integrin-associated protein CD9 in binding between sperm ADAM 2 and the egg integrin α6β1: Implications for murine fertilization Michellee S. Chen, Kenneth S. K. Tung, Scott A. Coonrod, Yuji Takahashi, Dora Bigler, Alice Chang, Yoshio Yamashita, Paul W. Kincade, John C. Herr, and Judith M. White PMCID: PMC18372 Regulation of nuclear translocation of Forkhead transcription factor AFX by protein kinase B Hiroshi Takaishi, Hiroaki Konishi, Hidenori Matsuzaki, Yoshitaka Ono, Yasuhito Shirai, Naoaki Saito, Tadahiro Kitamura, Wataru Ogawa, Masato Kasuga, Ushio Kikkawa, and Yasutomi Nishizuka PMCID: PMC18373 Optical recording of signal-mediated protein transport through single nuclear pore complexes Oliver Keminer, Jan-Peter Siebrasse, Katja Zerf, and Reiner Peters PMCID: PMC18374 The combined absence of the transcription factors Rel and RelA leads to multiple hemopoietic cell defects Mathis Grossmann, Donald Metcalf, Julie Merryfull, Amer Beg, David Baltimore, and Steve Gerondakis PMCID: PMC18375 β2-Chimaerin is a novel target for diacylglycerol: Binding properties and changes in subcellular localization mediated by ligand binding to its C1 domain Maria José Caloca, Maria Laura Garcia-Bermejo, Peter M. Blumberg, Nancy E. Lewin, Elisabeth Kremmer, Harald Mischak, Shaomeng Wang, Kassoum Nacro, Bruno Bienfait, Victor E. Marquez, and Marcelo G. Kazanietz PMCID: PMC18376 Inhibitory role of the host apoptogenic gene PKR in the establishment of persistent infection by encephalomyocarditis virus in U937 cells Michael C. Yeung, Danny L. Chang, Randell E. Camantigue, and Allan S. Lau PMCID: PMC18377 BRCA1-associated growth arrest is RB-dependent Olga N. Aprelikova, Bruno S. Fang, Eric G. Meissner, Shane Cotter, Mel Campbell, Aalok Kuthiala, Mika Bessho, Roy A. Jensen, and Edison T. Liu PMCID: PMC18378 Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency An Herreman, Dieter Hartmann, Wim Annaert, Paul Saftig, Katleen Craessaerts, Lutgarde Serneels, Lieve Umans, Vincent Schrijvers, Frédéric Checler, Hugo Vanderstichele, Veerle Baekelandt, Ralf Dressel, Philippe Cupers, Danny Huylebroeck, An Zwijsen, Fred Van Leuven, and Bart De Strooper PMCID: PMC18379 Imino sugars inhibit the formation and secretion of bovine viral diarrhea virus, a pestivirus model of hepatitis C virus: Implications for the development of broad spectrum anti-hepatitis virus agents Nicole Zitzmann, Anand S. Mehta, Sandra Carrouée, Terry D. Butters, Frances M. Platt, John McCauley, Baruch S. Blumberg, Raymond A. Dwek, and Timothy M. Block PMCID: PMC18380 Developmental Biology Direct visualization of the elt-2 gut-specific GATA factor binding to a target promoter inside the living Caenorhabditis elegans embryo Tetsunari Fukushige, Michael J. Hendzel, David P. Bazett-Jones, and James D. McGhee PMCID: PMC18381 Oogenic function of the myogenic factor D-MEF2: Negative regulation of the Decapentaplegic receptor gene thick veins Ekaterina Y. Mantrova, Robert A. Schulz, and Tien Hsu PMCID: PMC18382 Fgfr2 is required for limb outgrowth and lung-branching morphogenesis Esther Arman, Rebecca Haffner-Krausz, Marat Gorivodsky, and Peter Lonai PMCID: PMC18383 Reverse homeosis in homeotically reconstructed ribbonworms Michel Tarpin, Walter J. Gehring, and Jacques Bièrne PMCID: PMC18384 Evolution Individuality and adaptation across levels of selection: How shall we name and generalize the unit of Darwinism? Stephen Jay Gould and Elisabeth A. Lloyd PMCID: PMC18385 Pollinator preference and the evolution of floral traits in monkeyflowers (Mimulus) Douglas W. Schemske and H. D. Bradshaw, Jr. PMCID: PMC18386 Markov Chain Monte Carlo analysis of human Y-chromosome microsatellites provides evidence of biased mutation Gillian Cooper, Nigel J. Burroughs, David A. Rand, David C. Rubinsztein, and William Amos PMCID: PMC18387 Genetics Human and mouse homologs of Escherichia coli DinB (DNA polymerase IV), members of the UmuC/DinB superfamily Valerie L. Gerlach, L. Aravind, Garrett Gotway, Roger A. Schultz, Eugene V. Koonin, and Errol C. Friedberg PMCID: PMC18388 In vivo suppressor mutations correct a murine model of hereditary tyrosinemia type I Kara Manning, Muhsen Al-Dhalimy, Milton Finegold, and Markus Grompe PMCID: PMC18389 The yeast HML I silencer defines a heterochromatin domain boundary by directional establishment of silencing Xin Bi, Miriam Braunstein, Gan-Ju Shei, and James R. Broach PMCID: PMC18390 Drosophila proteins related to vertebrate DNA (5-cytosine) methyltransferases Ming-Shiu Hung, Narayanan Karthikeyan, Bauling Huang, Hshi-Chi Koo, John Kiger, and C.-K. James Shen PMCID: PMC18391 Disruption of the murine nuclear factor I-A gene (Nfia) results in perinatal lethality, hydrocephalus, and agenesis of the corpus callosum Liomar das Neves, Cynthia S. Duchala, Fatima Godinho, Musa A. Haxhiu, Clemencia Colmenares, Wendy B. Macklin, Christine E. Campbell, Kenneth G. Butz, and Richard M. Gronostajski PMCID: PMC18392 Immunology Differential effect of an Ig μ transgene on development of pre-B cells in fetal and adult SCID mice Gayle C. Bosma, Yung Chang, Hajime Karasuyama, and Melvin J. Bosma PMCID: PMC18393 Productive infection of double-negative T cells with HIV in vivo Gilles Marodon, David Warren, Michael C. Filomio, and David N. Posnett PMCID: PMC18394 Persistence of lymphocytic choriomeningitis virus at very low levels in immune mice Adrian Ciurea, Paul Klenerman, Lukas Hunziker, Edit Horvath, Bernhard Odermatt, Adrian F. Ochsenbein, Hans Hengartner, and Rolf M. Zinkernagel PMCID: PMC18395 Flanking nuclear matrix attachment regions synergize with the T cell receptor δ enhancer to promote V(D)J recombination Xiao-Ping Zhong, Juan Carabaña, and Michael S. Krangel PMCID: PMC18396 Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase Ken-ichi Ohya, Sachiko Kajigaya, Akira Kitanaka, Koji Yoshida, Akira Miyazato, Yoshihiro Yamashita, Takeo Yamanaka, Uichi Ikeda, Kazuyuki Shimada, Keiya Ozawa, and Hiroyuki Mano PMCID: PMC18397 Medical Sciences Parvalbumin gene transfer corrects diastolic dysfunction in diseased cardiac myocytes Philip A. Wahr, Daniel E. Michele, and Joseph M. Metzger PMCID: PMC18398 Spontaneous and antigen-induced production of HIV-inhibitory β-chemokines are associated with AIDS-free status Alfredo Garzino-Demo, Ronald B. Moss, Joseph B. Margolick, Farley Cleghorn, Anne Sill, William A. Blattner, Fiorenza Cocchi, Dennis J. Carlo, Anthony L. DeVico, and Robert C. Gallo PMCID: PMC18399 Cholesterol accumulation in tissues of the Niemann-Pick type C mouse is determined by the rate of lipoprotein-cholesterol uptake through the coated-pit pathway in each organ Chonglun Xie, Stephen D. Turley, and John M. Dietschy PMCID: PMC18400 Impaired growth and fertility of cAMP-specific phosphodiesterase PDE4D-deficient mice S.-L. Catherine Jin, François J. Richard, Wie-Peng Kuo, A. Joseph D’Ercole, and Marco Conti PMCID: PMC18401 Race-specific HIV-1 disease-modifying effects associated with CCR5 haplotypes Enrique Gonzalez, Mike Bamshad, Naoko Sato, Srinivas Mummidi, Rahul Dhanda, Gabriel Catano, Sonia Cabrera, Megan McBride, Xuan-Hien Cao, Gerald Merrill, Peter O’Connell, Donald W. Bowden, Barry I. Freedman, Stephanie A. Anderson, Elizabeth A. Walter, James S. Evans, Kevin T. Stephan, Robert A. Clark, Sanjay Tyagi, Seema S. Ahuja, Matthew J. Dolan, and Sunil K. Ahuja PMCID: PMC18402 Structurally similar oxidized phospholipids differentially regulate endothelial binding of monocytes and neutrophils Norbert Leitinger, Timothy R. Tyner, Laura Oslund, Cristina Rizza, Ganesamoorthy Subbanagounder, Hans Lee, Peggy T. Shih, Nigel Mackman, Gabor Tigyi, Mary C. Territo, Judith A. Berliner, and Devendra K. Vora PMCID: PMC18403 Suppression or induction of apoptosis by opposing pathways downstream from calcium-activated calcineurin Joseph Lotem, Rachel Kama, and Leo Sachs PMCID: PMC18404 Progesterone receptors in the thymus are required for thymic involution during pregnancy and for normal fertility Todd A. Tibbetts, Franco DeMayo, Susan Rich, Orla M. Conneely, and Bert W. O’Malley PMCID: PMC18405 Underdeveloped uterus and reduced estrogen responsiveness in mice with disruption of the estrogen-responsive finger protein gene, which is a direct target of estrogen receptor α Akira Orimo, Satoshi Inoue, Osamu Minowa, Nobuko Tominaga, Yasuhiro Tomioka, Miyuki Sato, Junko Kuno, Hisahiko Hiroi, Yoshihiko Shimizu, Masami Suzuki, Tetsuo Noda, and Masami Muramatsu PMCID: PMC18406 Identification of naturally processed and HLA-presented Epstein–Barr virus peptides recognized by CD4+ or CD8+ T lymphocytes from human blood Wolfgang Herr, Elena Ranieri, Andrea Gambotto, Lisa Salvucci Kierstead, Andrew A. Amoscato, Loreto Gesualdo, and Walter J. Storkus PMCID: PMC18407 Lentiviral delivery of HIV-1 Vpr protein induces apoptosis in transformed cells Sheila A. Stewart, Betty Poon, Jeremy B. M. Jowett, Yiming Xie, and Irvin S. Y. Chen PMCID: PMC18408 Visualizing the kinetics of tumor-cell clearance in living animals Thomas J. Sweeney, Volker Mailänder, Amanda A. Tucker, Adesuwa B. Olomu, Weisheng Zhang, Yu-an Cao, Robert S. Negrin, and Christopher H. Contag PMCID: PMC18409 Decreased selective uptake of high density lipoprotein cholesteryl esters in apolipoprotein E knock-out mice Takeshi Arai, Franz Rinninger, Lee Varban, Victoria Fairchild-Huntress, Chien-Ping Liang, Wengen Chen, Toru Seo, Richard Deckelbaum, Dennis Huszar, and Alan R. Tall PMCID: PMC18410 Microbiology Arterivirus discontinuous mRNA transcription is guided by base pairing between sense and antisense transcription-regulating sequences Guido van Marle, Jessika C. Dobbe, Alexander P. Gultyaev, Willem Luytjes, Willy J. M. Spaan, and Eric J. Snijder PMCID: PMC18411 Accumulation of specific RNAs encoding transcriptional factors and stress response proteins against a background of severe depletion of cellular RNAs in cells infected with herpes simplex virus 1 Nikolai N. Khodarev, Sunil J. Advani, Nalin Gupta, Bernard Roizman, and Ralph R. Weichselbaum PMCID: PMC18412 Neurobiology Release of calcium from stores alters the morphology of dendritic spines in cultured hippocampal neurons E. Korkotian and M. Segal PMCID: PMC18413 Dynamics of spatial summation in primary visual cortex of alert monkeys Mitesh K. Kapadia, Gerald Westheimer, and Charles D. Gilbert PMCID: PMC18414 Selective expression of the large neutral amino acid transporter at the blood–brain barrier Ruben J. Boado, Jian Yi Li, Marie Nagaya, Crystal Zhang, and William M. Pardridge PMCID: PMC18415 Evidence relating human verbal memory to hippocampal N-methyl-d-aspartate receptors Thomas Grunwald, Heinz Beck, Klaus Lehnertz, Ingmar Blümcke, Nico Pezer, Martin Kurthen, Guillen Fernández, Dirk Van Roost, Hans J. Heinze, Marta Kutas, and Christian E. Elger PMCID: PMC18416 Tonic inhibition alternates in paired neurons that set direction of fish escape reaction Kohei Hatta and Henri Korn PMCID: PMC18417 Resistance to excitotoxin-induced seizures and neuronal death in mice lacking the preprotachykinin A gene Hantao Liu, Yuqing Cao, Allan I. Basbaum, Andrey M. Mazarati, Raman Sankar, and Claude G. Wasterlain PMCID: PMC18418 An infection-based model of neurodevelopmental damage Mady Hornig, Herbert Weissenböck, Nigel Horscroft, and W. Ian Lipkin PMCID: PMC18419 Cognitive changes and modified processing of amyloid precursor protein in the cortical and hippocampal system after cholinergic synapse loss and muscarinic receptor activation L. Lin, B. Georgievska, A. Mattsson, and O. Isacson PMCID: PMC18420 Differential regulation of mammalian Period genes and circadian rhythmicity by cryptochromes 1 and 2 Martha Hotz Vitaterna, Christopher P. Selby, Takeshi Todo, Hitoshi Niwa, Carol Thompson, Ethan M. Fruechte, Kenichi Hitomi, Randy J. Thresher, Tomoko Ishikawa, Junichi Miyazaki, Joseph S. Takahashi, and Aziz Sancar PMCID: PMC18421 Long-term doxycycline-controlled expression of human tyrosine hydroxylase after direct adenovirus-mediated gene transfer to a rat model of Parkinson’s disease Olga Corti, Amelia Sánchez-Capelo, Philippe Colin, Naïma Hanoun, Michel Hamon, and Jacques Mallet PMCID: PMC18422 Diversity and distribution of nicotinic acetylcholine receptors in the locus ceruleus neurons Clément Léna, Alban de Kerchove d’Exaerde, Matilde Cordero-Erausquin, Nicolas Le Novère, Maria del Mar Arroyo-Jimenez, and Jean-Pierre Changeux PMCID: PMC18423 Impaired cerebellar synapse maturation in waggler, a mutant mouse with a disrupted neuronal calcium channel γ subunit Lu Chen, Shaowen Bao, Xiaoxi Qiao, and Richard F. Thompson PMCID: PMC18424 Feeding behavior in dopamine-deficient mice Mark S. Szczypka, Mark A. Rainey, Douglas S. Kim, William A. Alaynick, Brett T. Marck, Alvin M. Matsumoto, and Richard D. Palmiter PMCID: PMC18425 Endogenous activation of metabotropic glutamate receptors in neocortical development causes neuronal calcium oscillations Alexander C. Flint, Ryan S. Dammerman, and Arnold R. Kriegstein PMCID: PMC18426 RNA diversity has profound effects on the translation of neuronal nitric oxide synthase Yang Wang, Derek C. Newton, G. Brett Robb, Cheng-Lin Kau, Tricia L. Miller, Anthony H. Cheung, Anne V. Hall, Suzannah VanDamme, Josiah N. Wilcox, and Philip A. Marsden PMCID: PMC18427 Pharmacology Mimicry of erythropoietin by a nonpeptide molecule Sajjad A. Qureshi, Ronald M. Kim, Zenon Konteatis, Dawn E. Biazzo, Haideh Motamedi, Robert Rodrigues, Judith A. Boice, Jimmy R. Calaycay, Maria A. Bednarek, Patrick Griffin, Ying-Duo Gao, Kevin Chapman, and David F. Mark PMCID: PMC18428 Pharmacological plasticity of cardiac ATP-sensitive potassium channels toward diazoxide revealed by ADP Nathalie D’hahan, Christophe Moreau, Anne-Lise Prost, Hélène Jacquet, Alexey E. Alekseev, André Terzic, and Michel Vivaudou PMCID: PMC18429 XK469, a selective topoisomerase IIβ poison Hanlin Gao, Kuan-Chun Huang, Edith F. Yamasaki, Kenneth K. Chan, Lubna Chohan, and Robert M. Snapka PMCID: PMC18430 Physiology Diet-dependent hypercalciuria in transgenic mice with reduced CLC5 chloride channel expression Valerie A. Luyckx, Baudouin Leclercq, Lara K. Dowland, and Alan S. L. Yu PMCID: PMC18431 Continuous detection of extracellular ATP on living cells by using atomic force microscopy Stefan W. Schneider, Marie E. Egan, Bhanu P. Jena, William B. Guggino, H. Oberleithner, and John P. Geibel PMCID: PMC18432 Plant Biology Auxin-induced K+ channel expression represents an essential step in coleoptile growth and gravitropism Katrin Philippar, Ines Fuchs, Hartwig Lüthen, Stefan Hoth, Claudia S. Bauer, Ken Haga, Gerhard Thiel, Karin Ljung, Göran Sandberg, Michael Böttger, Dirk Becker, and Rainer Hedrich PMCID: PMC18433 Abscisic acid signal transduction in guard cells is mediated by phospholipase D activity Tobias Jacob, Sian Ritchie, Sarah M. Assmann, and Simon Gilroy PMCID: PMC18434 Psychology Pain modulation by release of the endogenous cannabinoid anandamide J. Michael Walker, Susan M. Huang, Nicole M. Strangman, Kang Tsou, and M. Clara Sañudo-Peña PMCID: PMC18435 Late maturation of visual spatial integration in humans Ilona Kovács, Petra Kozma, Ákos Fehér, and György Benedek PMCID: PMC18436 |
