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Volume 96(20);  September 28, 1999
Colloquium Papers
Proteolytic enzymes, past and future
Hans Neurath
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 10962–10963.
PMCID: PMC34226
Caspase activation: The induced-proximity model
Guy S. Salvesen and Vishva M. Dixit
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 10964–10967.
PMCID: PMC34227
Structural aspects of activation pathways of aspartic protease zymogens and viral 3C protease precursors
Amir R. Khan, Nina Khazanovich-Bernstein, Ernst M. Bergmann, and Michael N. G. James
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 10968–10975.
PMCID: PMC34228
The catalytic sites of 20S proteasomes and their role in subunit maturation: A mutational and crystallographic study
Michael Groll, Wolfgang Heinemeyer, Sibylle Jäger, Tobias Ullrich, Matthias Bochtler, Dieter H. Wolf, and Robert Huber
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 10976–10983.
PMCID: PMC34229
The structure of the human βII-tryptase tetramer: Fo(u)r better or worse
Christian P. Sommerhoff, Wolfram Bode, Pedro J. B. Pereira, Milton T. Stubbs, Jörg Stürzebecher, Gerd P. Piechottka, Gabriele Matschiner, and Andreas Bergner
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 10984–10991.
PMCID: PMC34230
Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for Patched
Naoyuki Fuse, Tapan Maiti, Baolin Wang, Jeffery A. Porter, Traci M. Tanaka Hall, Daniel J. Leahy, and Philip A. Beachy
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 10992–10999.
PMCID: PMC34231
Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes
D. A. Matthews, P. S. Dragovich, S. E. Webber, S. A. Fuhrman, A. K. Patick, L. S. Zalman, T. F. Hendrickson, R. A. Love, T. J. Prins, J. T. Marakovits, R. Zhou, J. Tikhe, C. E. Ford, J. W. Meador, R. A. Ferre, E. L. Brown, S. L. Binford, M. A. Brothers, D. M. DeLisle, and S. T. Worland
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11000–11007.
PMCID: PMC34232
Kinetic stability as a mechanism for protease longevity
Erin L. Cunningham, Sheila S. Jaswal, Julie L. Sohl, and David A. Agard
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11008–11014.
PMCID: PMC34233
Cysteine protease inhibitors as chemotherapy: Lessons from a parasite target
Paul M. Selzer, Sabine Pingel, Ivy Hsieh, Bernhard Ugele, Victor J. Chan, Juan C. Engel, Matthew Bogyo, David G. Russell, Judy A. Sakanari, and James H. McKerrow
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11015–11022.
PMCID: PMC34234
How the protease thrombin talks to cells
Shaun R. Coughlin
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11023–11027.
PMCID: PMC34235
VanX, a bacterial d-alanyl-d-alanine dipeptidase: Resistance, immunity, or survival function?
Ivan A. D. Lessard and Christopher T. Walsh
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11028–11032.
PMCID: PMC34236
Chaperone rings in protein folding and degradation
Arthur L. Horwich, Eilika U. Weber-Ban, and Daniel Finley
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11033–11040.
PMCID: PMC34237
A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood
Michael S. Brown and Joseph L. Goldstein
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11041–11048.
PMCID: PMC34238
Cellular mechanisms of β-amyloid production and secretion
Sukanto Sinha and Ivan Lieberburg
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11049–11053.
PMCID: PMC34239
Reverse biochemistry: Use of macromolecular protease inhibitors to dissect complex biological processes and identify a membrane-type serine protease in epithelial cancer and normal tissue
Toshihiko Takeuchi, Marc A. Shuman, and Charles S. Craik
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11054–11061.
PMCID: PMC34240
From the Academy
Introduction to Chinese-American Frontiers of Science
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11062.
PMCID: PMC34241
Determination of the Hubble constant
Wendy L. Freedman and Long Long Feng
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11063–11064.
PMCID: PMC34242
Automated biometrics-based personal identification
Weicheng Shen and Tieniu Tan
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11065–11066.
PMCID: PMC34243
Testing ancient RNA–protein interactions
Laura F. Landweber
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11067–11068.
PMCID: PMC34244
Crystal growth
Z. Zhang
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11069–11070.
PMCID: PMC34245
El Niño and the related phenomenon Southern Oscillation (ENSO): The largest signal in interannual climate variation
Hui-Jun Wang, Ren-He Zhang, Julie Cole, and Francisco Chavez
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11071–11072.
PMCID: PMC34246
Imaging the functioning human brain
Xuchu Weng, Yu-Shin Ding, and Nora D. Volkow
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11073–11074.
PMCID: PMC34247
Single molecule physics and chemistry
Chunli Bai, Chen Wang, X. Sunney Xie, and Peter G. Wolynes
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11075–11076.
PMCID: PMC34248
Commentaries
A nonlinear stimulus-response relation in bacterial chemotaxis
Ann M. Stock
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 10945–10947.
PMCID: PMC34220
Friedreich’s ataxia is a mitochondrial disorder
Jerry Kaplan
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 10948–10949.
PMCID: PMC34221
Effluxed lipids: Tangier Island’s latest export
Mason W. Freeman
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 10950–10952.
PMCID: PMC34222
NO news is good news
Charles J. Lowenstein
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 10953–10954.
PMCID: PMC34223
Perspective
Atmospheric oxygen over Phanerozoic time
Robert A. Berner
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 10955–10957.
PMCID: PMC34224
Latent reservoirs of HIV: Obstacles to the eradication of virus
Tae-Wook Chun and Anthony S. Fauci
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 10958–10961.
PMCID: PMC34225
Physical Sciences
Applied Physical Sciences
Combinatorial discovery of oxidative dehydrogenation catalysts within the Mo-V-Nb-O system
Peijun Cong, Ahmad Dehestani, Robert Doolen, Daniel M. Giaquinta, Shenheng Guan, Victor Markov, Damodara Poojary, Kyle Self, Howard Turner, and W. Henry Weinberg
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11077–11080.
PMCID: PMC17988
Chemistry
A chemically labeled cytotoxic agent: Two-photon fluorophore for optical tracking of cellular pathway in chemotherapy
Xiaopeng Wang, Linda J. Krebs, Mohammed Al-Nuri, Haridas E. Pudavar, Saswati Ghosal, Charles Liebow, Attila A. Nagy, Andrew V. Schally, and Paras N. Prasad
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11081–11084.
PMCID: PMC17989
Hierarchies and logarithmic oscillations in the temporal relaxation patterns of proteins and other complex systems
Ralf Metzler, Joseph Klafter, and Joshua Jortner
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11085–11089.
PMCID: PMC17990
A simple model for calculating the kinetics of protein folding from three-dimensional structures
Victor Muñoz and William A. Eaton
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11311–11316.
PMCID: PMC18030
Geophysics
Geologic constraints on clandestine nuclear testing in South Asia
Dan M. Davis and Lynn R. Sykes
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11090–11095.
PMCID: PMC17991
Mathematics
The curvature of a Hilbert module over C[z1, … , zd]
William Arveson
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11096–11099.
PMCID: PMC17992
Physics
Extended random sequential adsorption model of irreversible deposition processes: From simulations to experiments
P. Lavalle, P. Schaaf, M. Ostafin, J.-C. Voegel, and B. Senger
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11100–11105.
PMCID: PMC17993
Statistics
The simultaneous estimation of the number of signals and frequencies of multiple sinusoids when some observations are missing: I. Asymptotics
Zhidong Bai, Calyampudi R. Rao, Yuehua Wu, Mei-Mei Zen, and Lincheng Zhao
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11106–11110.
PMCID: PMC17994
Biological Sciences
Applied Biological Sciences
Tissue concentration of heparin, not administered dose, correlates with the biological response of injured arteries in vivo
Mark A. Lovich and Elazer R. Edelman
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11111–11116.
PMCID: PMC17995
Single-copy transgenic wheat generated through the resolution of complex integration patterns
Vibha Srivastava, Olin D. Anderson, and David W. Ow
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11117–11121.
PMCID: PMC17996
Ligand-receptor binding measured by laser-scanning imaging
Paul Zuck, Zhege Lao, Stephen Skwish, J. Fraser Glickman, Ke Yang, Jonathan Burbaum, and James Inglese
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11122–11127.
PMCID: PMC17997
Transient expression of a tumor-specific single-chain fragment and a chimeric antibody in tobacco leaves
Carmen Vaquero, Markus Sack, John Chandler, Jürgen Drossard, Flora Schuster, Michael Monecke, Stefan Schillberg, and Rainer Fischer
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11128–11133.
PMCID: PMC17998
Biochemistry
Purification and DNA binding properties of the ataxia-telangiectasia gene product ATM
Graeme C. M. Smith, Robert B. Cary, Nicholas D. Lakin, Byron C. Hann, Soo-Hwang Teo, David J. Chen, and Stephen P. Jackson
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11134–11139.
PMCID: PMC17999
GTP-dependent activation of urease apoprotein in complex with the UreD, UreF, and UreG accessory proteins
Aileen Soriano and Robert P. Hausinger
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11140–11144.
PMCID: PMC18000
Tanford–Kirkwood electrostatics for protein modeling
James J. Havranek and Pehr B. Harbury
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11145–11150.
PMCID: PMC18001
A bicarbonate ion as a general base in the mechanism of peptide hydrolysis by dizinc leucine aminopeptidase
Norbert Sträter, Lee Sun, E. R. Kantrowitz, and William N. Lipscomb
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11151–11155.
PMCID: PMC18002
Regulation of cyclin-dependent kinase 5 catalytic activity by phosphorylation
Pushkar Sharma, Monica Sharma, Niranjana D. Amin, R. Wayne Albers, and Harish C. Pant
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11156–11160.
PMCID: PMC18003
Conversion of mammalian 3α-hydroxysteroid dehydrogenase to 20α-hydroxysteroid dehydrogenase using loop chimeras: Changing specificity from androgens to progestins
Haiching Ma and Trevor M. Penning
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11161–11166.
PMCID: PMC18004
SMN mutants of spinal muscular atrophy patients are defective in binding to snRNP proteins
Livio Pellizzoni, Bernard Charroux, and Gideon Dreyfuss
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11167–11172.
PMCID: PMC18005
Suppression of Δ5-androstenediol-induced androgen receptor transactivation by selective steroids in human prostate cancer cells
Hong-Chiang Chang, Hiroshi Miyamoto, Padma Marwah, Henry Lardy, Shuyuan Yeh, Ko-En Huang, and Chawnshang Chang
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11173–11177.
PMCID: PMC18006
Conformational flexibility at the substrate binding site in the lactose permease of Escherichia coli
Adam B. Weinglass and H. Ronald Kaback
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11178–11182.
PMCID: PMC18007
An important base triple anchors the substrate helix recognition surface within the Tetrahymena ribozyme active site
Alexander A. Szewczak, Lori Ortoleva-Donnelly, Maris V. Zivarts, Adegboyega K. Oyelere, Alexei V. Kazantsev, and Scott A. Strobel
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11183–11188.
PMCID: PMC18008
Protease-activated receptor 1 is the primary mediator of thrombin-stimulated platelet procoagulant activity
Henrik Andersen, Daniel L. Greenberg, Kazuo Fujikawa, Wenfeng Xu, Dominic W. Chung, and Earl W. Davie
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11189–11193.
PMCID: PMC18009
Vacuole acidification is required for trans-SNARE pairing, LMA1 release, and homotypic fusion
Christian Ungermann, William Wickner, and Zuoyu Xu
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11194–11199.
PMCID: PMC18010
Verification of phylogenetic predictions in vivo and the importance of the tetraloop motif in a catalytic RNA
Daniel A. Pomeranz Krummel and Sidney Altman
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11200–11205.
PMCID: PMC18011
Chitin synthase III: Synthetic lethal mutants and “stress related” chitin synthesis that bypasses the CSD3/CHS6 localization pathway
Barbara C. Osmond, Charles A. Specht, and Phillips W. Robbins
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11206–11210.
PMCID: PMC18012
De novo amyloid proteins from designed combinatorial libraries
Michael W. West, Weixun Wang, Jennifer Patterson, Joseph D. Mancias, James R. Beasley, and Michael H. Hecht
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11211–11216.
PMCID: PMC18013
Estrogen induction of the cyclin D1 promoter: Involvement of a cAMP response-like element
Michele Sabbah, Delphine Courilleau, Jan Mester, and Gerard Redeuilh
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11217–11222.
PMCID: PMC18014
A cooperative oxygen-binding hemoglobin from Mycobacterium tuberculosis
Manon Couture, Syun-Ru Yeh, Beatrice A. Wittenberg, Jonathan B. Wittenberg, Yannick Ouellet, Denis L. Rousseau, and Michel Guertin
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11223–11228.
PMCID: PMC18015
Quinolone signaling in the cell-to-cell communication system of Pseudomonas aeruginosa
Everett C. Pesci, Jared B. J. Milbank, James P. Pearson, Susan McKnight, Andrew S. Kende, E. Peter Greenberg, and Barbara H. Iglewski
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11229–11234.
PMCID: PMC18016
Sterols regulate cycling of SREBP cleavage-activating protein (SCAP) between endoplasmic reticulum and Golgi
Axel Nohturfft, Russell A. DeBose-Boyd, Sigrid Scheek, Joseph L. Goldstein, and Michael S. Brown
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11235–11240.
PMCID: PMC18017
Circular permutation and receptor insertion within green fluorescent proteins
Geoffrey S. Baird, David A. Zacharias, and Roger Y. Tsien
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11241–11246.
PMCID: PMC18018
Equilibria and kinetics of folding of gelsolin domain 2 and mutants involved in familial amyloidosis–Finnish type
Rivka L. Isaacson, Alan G. Weeds, and Alan R. Fersht
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11247–11252.
PMCID: PMC18019
Ovochymase, a Xenopus laevis egg extracellular protease, is translated as part of an unusual polyprotease
LeAnn L. Lindsay, Joy C. Yang, and Jerry L. Hedrick
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11253–11258.
PMCID: PMC18020
The M2–2 protein of human respiratory syncytial virus is a regulatory factor involved in the balance between RNA replication and transcription
Alison Bermingham and Peter L. Collins
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11259–11264.
PMCID: PMC18021
Biophysics
Solution structure of Apaf-1 CARD and its interaction with caspase-9 CARD: A structural basis for specific adaptor/caspase interaction
Pei Zhou, James Chou, Roberto Sanchez Olea, Junying Yuan, and Gerhard Wagner
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11265–11270.
PMCID: PMC18022
The dynamics of structural deformations of immobilized single light-harvesting complexes
Martin A. Bopp, Alexander Sytnik, Tina D. Howard, Richard J. Cogdell, and Robin M. Hochstrasser
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11271–11276.
PMCID: PMC18023
Dynamic force spectroscopy of single DNA molecules
Torsten Strunz, Krisztina Oroszlan, Rolf Schäfer, and Hans-Joachim Güntherodt
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11277–11282.
PMCID: PMC18024
The 28–111 disulfide bond constrains the α-lactalbumin molten globule and weakens its cooperativity of folding
Yongzhang Luo and Robert L. Baldwin
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11283–11287.
PMCID: PMC18025
Atomic force microscopy captures length phenotypes in single proteins
Mariano Carrion-Vazquez, Piotr E. Marszalek, Andres F. Oberhauser, and Julio M. Fernandez
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11288–11292.
PMCID: PMC18026
Evidence for the role of PrPC helix 1 in the hydrophilic seeding of prion aggregates
M. P. Morrissey and E. I. Shakhnovich
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11293–11298.
PMCID: PMC18027
A theoretical search for folding/unfolding nuclei in three-dimensional protein structures
Oxana V. Galzitskaya and Alexei V. Finkelstein
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11299–11304.
PMCID: PMC18028
Prediction of protein-folding mechanisms from free-energy landscapes derived from native structures
E. Alm and D. Baker
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11305–11310.
PMCID: PMC18029
A simple model for calculating the kinetics of protein folding from three-dimensional structures
Victor Muñoz and William A. Eaton
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11311–11316.
PMCID: PMC18030
Cell Biology
Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons
Christian Gieffers, Beate H. Peters, Edgar R. Kramer, Carlos G. Dotti, and Jan-Michael Peters
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11317–11322.
PMCID: PMC18031
Tubulointerstitial nephritis antigen: An extracellular matrix protein that selectively regulates tubulogenesis vs. glomerulogenesis during mammalian renal development
Yashpal S. Kanwar, Anil Kumar, Qiwei Yang, Yufeng Tian, Jun Wada, Naoki Kashihara, and Elisabeth I. Wallner
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11323–11328.
PMCID: PMC18032
Galectin-7 overexpression is associated with the apoptotic process in UVB-induced sunburn keratinocytes
Francoise Bernerd, Alain Sarasin, and Thierry Magnaldo
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11329–11334.
PMCID: PMC18033
Mitogen-activated protein kinase kinase activity is required for the G2/M transition of the cell cycle in mammalian fibroblasts
Jocelyn H. Wright, Erlynda Munar, Damon R. Jameson, Paul R. Andreassen, Robert L. Margolis, Rony Seger, and Edwin G. Krebs
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11335–11340.
PMCID: PMC18034
Phenotypic reversal of the btn1 defects in yeast by chloroquine: A yeast model for Batten disease
David A. Pearce, Carrie J. Carr, Biswadip Das, and Fred Sherman
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11341–11345.
PMCID: PMC18035
Response tuning in bacterial chemotaxis
Ravi Jasuja, Yu-Lin, David R. Trentham, and Shahid Khan
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11346–11351.
PMCID: PMC18036
A quantitative analysis of the kinetics of the G2 DNA damage checkpoint system
Baltazar D. Aguda
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11352–11357.
PMCID: PMC18037
Cholesterol efflux to apolipoprotein AI involves endocytosis and resecretion in a calcium-dependent pathway
Yukihiro Takahashi and Jonathan D. Smith
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11358–11363.
PMCID: PMC18038
RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination
Kevin L. Lorick, Jane P. Jensen, Shengyun Fang, Albert M. Ong, Shigetsugu Hatakeyama, and Allan M. Weissman
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11364–11369.
PMCID: PMC18039
Autoproteolysis in nucleoporin biogenesis
Jonathan S. Rosenblum and Günter Blobel
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11370–11375.
PMCID: PMC18040
Developmental Biology
Multiple left-right asymmetry defects in Shh−/− mutant mice unveil a convergence of the Shh and retinoic acid pathways in the control of Lefty-1
Tohru Tsukui, Javier Capdevila, Koji Tamura, Pilar Ruiz-Lozano, Concepción Rodriguez-Esteban, Sayuri Yonei-Tamura, Jorge Magallón, Roshantha A. S. Chandraratna, Kenneth Chien, Bruce Blumberg, Ronald M. Evans, and Juan Carlos Izpisúa Belmonte
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11376–11381.
PMCID: PMC18041
Dominant-negative mutation in the β2 and β6 proteasome subunit genes affect alternative cell fate decisions in the Drosophila sense organ lineage
François Schweisguth
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11382–11386.
PMCID: PMC18042
Ecology
Ecosystem rooting depth determined with caves and DNA
R. B. Jackson, L. A. Moore, W. A. Hoffmann, W. T. Pockman, and C. R. Linder
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11387–11392.
PMCID: PMC18043
Evolution
Spontaneous deleterious mutation in Arabidopsis thaliana
Stewart T. Schultz, Michael Lynch, and John H. Willis
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11393–11398.
PMCID: PMC18044
Genetic and environmental conditions that increase longevity in Caenorhabditis elegans decrease metabolic rate
Wayne A. Van Voorhies and Samuel Ward
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11399–11403.
PMCID: PMC18045
Genetics
Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells
A. Kazantsev, E. Preisinger, A. Dranovsky, D. Goldgaber, and D. Housman
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11404–11409.
PMCID: PMC18046
Platelet-derived growth factor β receptor regulates interstitial fluid homeostasis through phosphatidylinositol-3′ kinase signaling
Rainer Heuchel, Ansgar Berg, Michelle Tallquist, Karina Åhlén, Rolf K. Reed, Kristofer Rubin, Lena Claesson-Welsh, Carl-Henrik Heldin, and Philippe Soriano
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11410–11415.
PMCID: PMC18047
The Arabidopsis SKP1-LIKE1 gene is essential for male meiosis and may control homologue separation
Ming Yang, Yi Hu, Muhammad Lodhi, W. Richard McCombie, and Hong Ma
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11416–11421.
PMCID: PMC18048
Genomic sequence, structural organization, molecular evolution, and aberrant rearrangement of promyelocytic leukemia zinc finger gene
T. Zhang, H. Xiong, L.-X. Kan, C.-K. Zhang, X.-F. Jiao, G. Fu, Q.-H. Zhang, L. Lu, J.-H. Tong, B.-W. Gu, M. Yu, J.-X. Liu, J. Licht, S. Waxman, A. Zelent, E. Chen, and S.-J. Chen
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11422–11427.
PMCID: PMC18049
Hyperactive transposase mutants of the Himar1 mariner transposon
David J. Lampe, Brian J. Akerley, Eric J. Rubin, John J. Mekalanos, and Hugh M. Robertson
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11428–11433.
PMCID: PMC18050
Position effect of human telomeric repeats on replication timing
R. Ofir, A. C. C. Wong, H. E. McDermid, K. L. Skorecki, and S. Selig
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11434–11439.
PMCID: PMC18051
CDC45 and DPB11 are required for processive DNA replication and resistance to DNA topoisomerase I-mediated DNA damage
Robert J. D. Reid, Paola Fiorani, Mizuno Sugawara, and Mary-Ann Bjornsti
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11440–11445.
PMCID: PMC18052
Immunology
Thermodynamics of T cell receptor binding to peptide–MHC: Evidence for a general mechanism of molecular scanning
J. Jay Boniface, Ziv Reich, Daniel S. Lyons, and Mark M. Davis
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11446–11451.
PMCID: PMC18053
Multiple, targeted deficiencies in selectins reveal a predominant role for P-selectin in leukocyte recruitment
Stephen D. Robinson, Paul S. Frenette, Helen Rayburn, Marge Cummiskey, Mollie Ullman-Culleré, Denisa D. Wagner, and Richard O. Hynes
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11452–11457.
PMCID: PMC18054
Novel neurotrophin-1/B cell-stimulating factor-3: A cytokine of the IL-6 family
Giorgio Senaldi, Brian C. Varnum, Ulla Sarmiento, Charlie Starnes, Jackson Lile, Sheila Scully, Jane Guo, Gary Elliott, Jennifer McNinch, Christine L. Shaklee, Daniel Freeman, Frank Manu, W. Scott Simonet, Thomas Boone, and Ming-Shi Chang
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11458–11463.
PMCID: PMC18055
Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia
John R. McWhirter, Saskia T. C. Neuteboom, Edward V. Wancewicz, Brett P. Monia, James R. Downing, and Cornelis Murre
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11464–11469.
PMCID: PMC18056
Class I MHC molecules on hematopoietic cells can support intrathymic positive selection of T cell receptor transgenic T cells
Jens Zerrahn, Ariane Volkmann, Mark C. Coles, Werner Held, Francois A. Lemonnier, and David H. Raulet
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11470–11475.
PMCID: PMC18057
In vivo blockade of CTLA-4 enhances the priming of responsive T cells but fails to prevent the induction of tumor antigen-specific tolerance
Eduardo M. Sotomayor, Ivan Borrello, Erev Tubb, James P. Allison, and Hyam I. Levitsky
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11476–11481.
PMCID: PMC18058
Medical Sciences
An anti-CD45RO immunotoxin eliminates T cells latently infected with HIV-1 in vitro
Cynthia McCoig, Gregory Van Dyke, Chin-Sheng Chou, Louis J. Picker, Octavio Ramilo, and Ellen S. Vitetta
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11482–11485.
PMCID: PMC18059
A putative mechanism of demyelination in multiple sclerosis by a proteolytic enzyme, calpain
Donald C. Shields, Kurt E. Schaecher, Takaomi C. Saido, and Naren L. Banik
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11486–11491.
PMCID: PMC18060
Deficit of in vivo mitochondrial ATP production in patients with Friedreich ataxia
Raffaele Lodi, J. Mark Cooper, Jane L. Bradley, David Manners, Peter Styles, Doris J. Taylor, and Anthony H. V. Schapira
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11492–11495.
PMCID: PMC18061
An endothelin receptor B antagonist inhibits growth and induces cell death in human melanoma cells in vitro and in vivo
Ronit Lahav, Garrett Heffner, and Paul H. Patterson
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11496–11500.
PMCID: PMC18062
Mice without phosphatidylcholine transfer protein have no defects in the secretion of phosphatidylcholine into bile or into lung airspaces
Ardy van Helvoort, Arjan de Brouwer, Roelof Ottenhoff, Jos F. H. M. Brouwers, Jan Wijnholds, Jos H. Beijnen, Anita Rijneveld, Tom van der Poll, Martin A. van der Valk, Donné Majoor, Wim Voorhout, Karel W. A. Wirtz, Ronald P. J. Oude Elferink, and Piet Borst
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11501–11506.
PMCID: PMC18063
The late phase of ischemic preconditioning is abrogated by targeted disruption of the inducible NO synthase gene
Yiru Guo, W. Keith Jones, Yu-Ting Xuan, Xian-Liang Tang, Weike Bao, Wen-Jian Wu, Hui Han, Victor E. Laubach, Peipei Ping, Zequan Yang, Yumin Qiu, and Roberto Bolli
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11507–11512.
PMCID: PMC18064
Troglitazone prevents mitochondrial alterations, β cell destruction, and diabetes in obese prediabetic rats
Moritake Higa, Yan-Ting Zhou, Mariella Ravazzola, Danielle Baetens, Lelio Orci, and Roger H. Unger
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11513–11518.
PMCID: PMC18065
Detection of human neurotropic JC virus DNA sequence and expression of the viral oncogenic protein in pediatric medulloblastomas
Barbara Krynska, Luis Del Valle, Sidney Croul, Jennifer Gordon, Christos D. Katsetos, Michele Carbone, Antonio Giordano, and Kamel Khalili
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11519–11524.
PMCID: PMC18066
3-Hydroxy-3-methylglutaryl CoA reductase inhibitors up-regulate transforming growth factor-β signaling in cultured heart cells via inhibition of geranylgeranylation of RhoA GTPase
Ho-Jin Park and Jonas B. Galper
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11525–11530.
PMCID: PMC18067
Soluble member(s) of the mesothelin/megakaryocyte potentiating factor family are detectable in sera from patients with ovarian carcinoma
Nathalie Scholler, Ning Fu, Yi Yang, Zhengmao Ye, Gary E. Goodman, Karl Erik Hellström, and Ingegerd Hellström
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11531–11536.
PMCID: PMC18068
IL-18 binding and inhibition of interferon γ induction by human poxvirus-encoded proteins
Yan Xiang and Bernard Moss
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11537–11542.
PMCID: PMC18069
Lpsd/Ran of endotoxin-resistant C3H/HeJ mice is defective in mediating lipopolysaccharide endotoxin responses
Peter M. C. Wong, Anthony Kang, Hong Chen, Quan Yuan, Peidong Fan, Barnet M. Sultzer, Yuet Wai Kan, and Siu-Wah Chung
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11543–11548.
PMCID: PMC18070
A simple relationship between viral load and survival time in HIV-1 infection
Ramy A. Arnaout, Alun L. Lloyd, Thomas R. O’Brien, James J. Goedert, John M. Leonard, and Martin A. Nowak
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11549–11553.
PMCID: PMC18071
Microbiology
Identification of Mycobacterium tuberculosis RNAs synthesized in response to phagocytosis by human macrophages by selective capture of transcribed sequences (SCOTS)
James E. Graham and Josephine E. Clark-Curtiss
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11554–11559.
PMCID: PMC18072
A coding RNA sequence acts as a replication signal in cardioviruses
Pierre-Emmanuel Lobert, Nicolas Escriou, Jean Ruelle, and Thomas Michiels
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11560–11565.
PMCID: PMC18073
Three unrelated viral transforming proteins (vIRF, EBNA2, and E1A) induce the MYC oncogene through the interferon-responsive PRF element by using different transcription coadaptors
Sukhanya Jayachandra, Kenneth G. Low, Ai-En Thlick, Jin Yu, Paul D. Ling, Yuan Chang, and Patrick S. Moore
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11566–11571.
PMCID: PMC18074
Association of HIV-1 Tat with the cellular protein, Purα, is mediated by RNA
Gary L. Gallia, Nune Darbinian, Anna Tretiakova, Sameer A. Ansari, Jay Rappaport, John Brady, Margaret J. Wortman, Edward M. Johnson, and Kamel Khalili
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11572–11577.
PMCID: PMC18075
DNA adenine methylase mutants of Salmonella typhimurium show defects in protein secretion, cell invasion, and M cell cytotoxicity
Francisco García-Del Portillo, M. Graciela Pucciarelli, and Josep Casadesús
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11578–11583.
PMCID: PMC18076
Titanospirillum velox: A huge, speedy, sulfur-storing spirillum from Ebro Delta microbial mats
Ricardo Guerrero, Aaron Haselton, Mónica Solé, Andrew Wier, and Lynn Margulis
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11584–11588.
PMCID: PMC18077
Neurobiology
Slow transport of unpolymerized tubulin and polymerized neurofilament in the squid giant axon
James A. Galbraith, Thomas S. Reese, Michelle L. Schlief, and Paul E. Gallant
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11589–11594.
PMCID: PMC18078
Altered anxiety and weight gain in corticotropin-releasing hormone-binding protein-deficient mice
I. Jill Karolyi, Heather L. Burrows, Tennore M. Ramesh, Masaharu Nakajima, J. Shonee Lesh, Eunju Seong, Sally A. Camper, and Audrey F. Seasholtz
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11595–11600.
PMCID: PMC18079
Distinctive compartmental organization of human primary visual cortex
Todd M. Preuss, Huixin Qi, and Jon H. Kaas
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11601–11606.
PMCID: PMC18080
D2 dopamine receptors induce mitogen-activated protein kinase and cAMP response element-binding protein phosphorylation in neurons
Zhen Yan, Jian Feng, Allen A. Fienberg, and Paul Greengard
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11607–11612.
PMCID: PMC18081
IL-1β differentially regulates calcium wave propagation between primary human fetal astrocytes via pathways involving P2 receptors and gap junction channels
Gareth R. John, Eliana Scemes, Sylvia O. Suadicani, Judy S. H. Liu, Peter C. Charles, Sunhee C. Lee, David C. Spray, and Celia F. Brosnan
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11613–11618.
PMCID: PMC18082
Regeneration of a germinal layer in the adult mammalian brain
Fiona Doetsch, Jose Manuel García-Verdugo, and Arturo Alvarez-Buylla
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11619–11624.
PMCID: PMC18083
Central representation of time during motor learning
Michael A. Conditt and Ferdinando A. Mussa-Ivaldi
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11625–11630.
PMCID: PMC18084
Selective glutamate receptor antagonists can induce or prevent axonal sprouting in rat hippocampal slice cultures
R. Anne McKinney, Andreas Lüthi, Christine E. Bandtlow, Beat H. Gähwiler, and Scott M. Thompson
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11631–11636.
PMCID: PMC18085
The unseen color aftereffect of an unseen stimulus: Insight from blindsight into mechanisms of color afterimages
John L. Barbur, Lawrence Weiskrantz, and J. Alister Harlow
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11637–11641.
PMCID: PMC18086
Basolateral amygdala noradrenergic influence enables enhancement of memory consolidation induced by hippocampal glucocorticoid receptor activation
Benno Roozendaal, Bichngoc T. Nguyen, Ann E. Power, and James L. McGaugh
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11642–11647.
PMCID: PMC18087
Pharmacology
Gene transfer of endothelial nitric oxide synthase to the penis augments erectile responses in the aged rat
H. C. Champion, T. J. Bivalacqua, A. L. Hyman, L. J. Ignarro, W. J. G. Hellstrom, and P. J. Kadowitz
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11648–11652.
PMCID: PMC18088
Physiology
Neutral endopeptidase (EC 3.4.24.11) terminates colitis by degrading substance P
S. Sturiale, G. Barbara, B. Qiu, M. Figini, P. Geppetti, N. Gerard, C. Gerard, E. F. Grady, N. W. Bunnett, and S. M. Collins
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11653–11658.
PMCID: PMC18089
Plant Biology
Different circadian oscillators control Ca2+ fluxes and Lhcb gene expression
Jiqing Sai and Carl Hirschie Johnson
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11659–11663.
PMCID: PMC18090
Molecular analysis of NOZZLE, a gene involved in pattern formation and early sporogenesis during sex organ development in Arabidopsis thaliana
Ursula Schiefthaler, Sureshkumar Balasubramanian, Patrick Sieber, David Chevalier, Ellen Wisman, and Kay Schneitz
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11664–11669.
PMCID: PMC18091
Genomic context influences the activity of maize mitochondrial cox2 promoters
D. Shelley Lupold, Angelina G. F. S. Caoile, and David B. Stern
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11670–11675.
PMCID: PMC18092
Antisense-mediated silencing of a gene encoding a major ryegrass pollen allergen
Prem L. Bhalla, Ines Swoboda, and Mohan B. Singh
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11676–11680.
PMCID: PMC18093
Psychology
Measuring the amplification of attention
Erik Blaser, George Sperling, and Zhong-Lin Lu
Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11681–11686.
PMCID: PMC18094
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