| | This journal provides immediate access to some articles. Colloquium Papers Proteolytic enzymes, past and future Hans Neurath Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 10962–10963. PMCID: PMC34226 Caspase activation: The induced-proximity model Guy S. Salvesen and Vishva M. Dixit Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 10964–10967. PMCID: PMC34227 Structural aspects of activation pathways of aspartic protease
zymogens and viral 3C protease precursors Amir R. Khan, Nina Khazanovich-Bernstein, Ernst M. Bergmann, and Michael N. G. James Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 10968–10975. PMCID: PMC34228 The catalytic sites of 20S proteasomes and their role in subunit
maturation: A mutational and crystallographic study Michael Groll, Wolfgang Heinemeyer, Sibylle Jäger, Tobias Ullrich, Matthias Bochtler, Dieter H. Wolf, and Robert Huber Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 10976–10983. PMCID: PMC34229 The structure of the human βII-tryptase tetramer: Fo(u)r better
or worse Christian P. Sommerhoff, Wolfram Bode, Pedro J. B. Pereira, Milton T. Stubbs, Jörg Stürzebecher, Gerd P. Piechottka, Gabriele Matschiner, and Andreas Bergner Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 10984–10991. PMCID: PMC34230 Sonic hedgehog protein signals not as a hydrolytic enzyme but as
an apparent ligand for Patched Naoyuki Fuse, Tapan Maiti, Baolin Wang, Jeffery A. Porter, Traci M. Tanaka Hall, Daniel J. Leahy, and Philip A. Beachy Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 10992–10999. PMCID: PMC34231 Structure-assisted design of mechanism-based irreversible
inhibitors of human rhinovirus 3C protease with potent antiviral
activity against multiple rhinovirus serotypes D. A. Matthews, P. S. Dragovich, S. E. Webber, S. A. Fuhrman, A. K. Patick, L. S. Zalman, T. F. Hendrickson, R. A. Love, T. J. Prins, J. T. Marakovits, R. Zhou, J. Tikhe, C. E. Ford, J. W. Meador, R. A. Ferre, E. L. Brown, S. L. Binford, M. A. Brothers, D. M. DeLisle, and S. T. Worland Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11000–11007. PMCID: PMC34232 Kinetic stability as a mechanism for protease longevity Erin L. Cunningham, Sheila S. Jaswal, Julie
L. Sohl, and David A. Agard Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11008–11014. PMCID: PMC34233 Cysteine protease inhibitors as chemotherapy: Lessons from a
parasite target Paul M. Selzer, Sabine Pingel, Ivy Hsieh, Bernhard Ugele, Victor J. Chan, Juan C. Engel, Matthew Bogyo, David G. Russell, Judy A. Sakanari, and James H. McKerrow Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11015–11022. PMCID: PMC34234 How the protease thrombin talks to cells Shaun R. Coughlin Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11023–11027. PMCID: PMC34235 VanX, a bacterial d-alanyl-d-alanine
dipeptidase: Resistance, immunity, or survival function? Ivan A. D. Lessard and Christopher T. Walsh Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11028–11032. PMCID: PMC34236 Chaperone rings in protein folding and degradation Arthur L. Horwich, Eilika U. Weber-Ban, and Daniel Finley Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11033–11040. PMCID: PMC34237 A proteolytic pathway that controls the cholesterol content of
membranes, cells, and blood Michael S. Brown and Joseph L. Goldstein Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11041–11048. PMCID: PMC34238 Cellular mechanisms of β-amyloid production and secretion Sukanto Sinha and Ivan Lieberburg Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11049–11053. PMCID: PMC34239 Reverse biochemistry: Use of macromolecular protease inhibitors
to dissect complex biological processes and identify a
membrane-type serine protease in epithelial cancer and
normal tissue Toshihiko Takeuchi, Marc A. Shuman, and Charles S. Craik Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11054–11061. PMCID: PMC34240 From the Academy Introduction to Chinese-American Frontiers of Science Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11062. PMCID: PMC34241 Determination of the Hubble constant Wendy L. Freedman and Long Long Feng Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11063–11064. PMCID: PMC34242 Automated biometrics-based personal identification Weicheng Shen and Tieniu Tan Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11065–11066. PMCID: PMC34243 Testing ancient RNA–protein interactions Laura F. Landweber Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11067–11068. PMCID: PMC34244 Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11069–11070. PMCID: PMC34245 El Niño and the related phenomenon Southern Oscillation
(ENSO): The largest signal in interannual climate variation Hui-Jun Wang, Ren-He Zhang, Julie Cole, and Francisco Chavez Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11071–11072. PMCID: PMC34246 Imaging the functioning human brain Xuchu Weng, Yu-Shin Ding, and Nora D. Volkow Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11073–11074. PMCID: PMC34247 Single molecule physics and chemistry Chunli Bai, Chen Wang, X. Sunney Xie, and Peter G. Wolynes Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11075–11076. PMCID: PMC34248 Commentaries A nonlinear stimulus-response relation in bacterial chemotaxis Ann M. Stock Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 10945–10947. PMCID: PMC34220 Friedreich’s ataxia is a mitochondrial disorder Jerry Kaplan Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 10948–10949. PMCID: PMC34221 Effluxed lipids: Tangier Island’s latest export Mason W. Freeman Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 10950–10952. PMCID: PMC34222 NO news is good news Charles J. Lowenstein Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 10953–10954. PMCID: PMC34223 Perspective Atmospheric oxygen over Phanerozoic time Robert A. Berner Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 10955–10957. PMCID: PMC34224 Latent reservoirs of HIV: Obstacles to the eradication of virus Tae-Wook Chun and Anthony S. Fauci Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 10958–10961. PMCID: PMC34225 Physical Sciences Applied Physical Sciences Combinatorial discovery of oxidative dehydrogenation catalysts within the Mo-V-Nb-O system Peijun Cong, Ahmad Dehestani, Robert Doolen, Daniel M. Giaquinta, Shenheng Guan, Victor Markov, Damodara Poojary, Kyle Self, Howard Turner, and W. Henry Weinberg Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11077–11080. PMCID: PMC17988 Chemistry A chemically labeled cytotoxic agent: Two-photon fluorophore for optical tracking of cellular pathway in chemotherapy Xiaopeng Wang, Linda J. Krebs, Mohammed Al-Nuri, Haridas E. Pudavar, Saswati Ghosal, Charles Liebow, Attila A. Nagy, Andrew V. Schally, and Paras N. Prasad Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11081–11084. PMCID: PMC17989 Hierarchies and logarithmic oscillations in the temporal relaxation patterns of proteins and other complex systems Ralf Metzler, Joseph Klafter, and Joshua Jortner Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11085–11089. PMCID: PMC17990 A simple model for calculating the kinetics of protein folding from three-dimensional structures Victor Muñoz and William A. Eaton Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11311–11316. PMCID: PMC18030 Geophysics Geologic constraints on clandestine nuclear testing in South Asia Dan M. Davis and Lynn R. Sykes Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11090–11095. PMCID: PMC17991 Mathematics The curvature of a Hilbert module over ![C](corehtml/pmc/pmcents/02102.gif) [ z1, … , zd] William Arveson Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11096–11099. PMCID: PMC17992 Physics Extended random sequential adsorption model of irreversible deposition processes: From simulations to experiments P. Lavalle, P. Schaaf, M. Ostafin, J.-C. Voegel, and B. Senger Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11100–11105. PMCID: PMC17993 Statistics The simultaneous estimation of the number of signals and frequencies of multiple sinusoids when some observations are missing: I. Asymptotics Zhidong Bai, Calyampudi R. Rao, Yuehua Wu, Mei-Mei Zen, and Lincheng Zhao Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11106–11110. PMCID: PMC17994 Biological Sciences Applied Biological Sciences Tissue concentration of heparin, not administered dose, correlates with the biological response of injured arteries in vivo Mark A. Lovich and Elazer R. Edelman Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11111–11116. PMCID: PMC17995 Single-copy transgenic wheat generated through the resolution of complex integration patterns Vibha Srivastava, Olin D. Anderson, and David W. Ow Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11117–11121. PMCID: PMC17996 Ligand-receptor binding measured by laser-scanning imaging Paul Zuck, Zhege Lao, Stephen Skwish, J. Fraser Glickman, Ke Yang, Jonathan Burbaum, and James Inglese Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11122–11127. PMCID: PMC17997 Transient expression of a tumor-specific single-chain fragment and a chimeric antibody in tobacco leaves Carmen Vaquero, Markus Sack, John Chandler, Jürgen Drossard, Flora Schuster, Michael Monecke, Stefan Schillberg, and Rainer Fischer Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11128–11133. PMCID: PMC17998 Biochemistry Purification and DNA binding properties of the ataxia-telangiectasia gene product ATM Graeme C. M. Smith, Robert B. Cary, Nicholas D. Lakin, Byron C. Hann, Soo-Hwang Teo, David J. Chen, and Stephen P. Jackson Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11134–11139. PMCID: PMC17999 GTP-dependent activation of urease apoprotein in complex with the UreD, UreF, and UreG accessory proteins Aileen Soriano and Robert P. Hausinger Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11140–11144. PMCID: PMC18000 Tanford–Kirkwood electrostatics for protein modeling James J. Havranek and Pehr B. Harbury Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11145–11150. PMCID: PMC18001 A bicarbonate ion as a general base in the mechanism of peptide hydrolysis by dizinc leucine aminopeptidase Norbert Sträter, Lee Sun, E. R. Kantrowitz, and William N. Lipscomb Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11151–11155. PMCID: PMC18002 Regulation of cyclin-dependent kinase 5 catalytic activity by phosphorylation Pushkar Sharma, Monica Sharma, Niranjana D. Amin, R. Wayne Albers, and Harish C. Pant Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11156–11160. PMCID: PMC18003 Conversion of mammalian 3α-hydroxysteroid dehydrogenase to 20α-hydroxysteroid dehydrogenase using loop chimeras: Changing specificity from androgens to progestins Haiching Ma and Trevor M. Penning Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11161–11166. PMCID: PMC18004 SMN mutants of spinal muscular atrophy patients are defective in binding to snRNP proteins Livio Pellizzoni, Bernard Charroux, and Gideon Dreyfuss Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11167–11172. PMCID: PMC18005 Suppression of Δ5-androstenediol-induced androgen receptor transactivation by selective steroids in human prostate cancer cells Hong-Chiang Chang, Hiroshi Miyamoto, Padma Marwah, Henry Lardy, Shuyuan Yeh, Ko-En Huang, and Chawnshang Chang Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11173–11177. PMCID: PMC18006 Conformational flexibility at the substrate binding site in the lactose permease of Escherichia coli Adam B. Weinglass and H. Ronald Kaback Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11178–11182. PMCID: PMC18007 An important base triple anchors the substrate helix recognition surface within the Tetrahymena ribozyme active site Alexander A. Szewczak, Lori Ortoleva-Donnelly, Maris V. Zivarts, Adegboyega K. Oyelere, Alexei V. Kazantsev, and Scott A. Strobel Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11183–11188. PMCID: PMC18008 Protease-activated receptor 1 is the primary mediator of thrombin-stimulated platelet procoagulant activity Henrik Andersen, Daniel L. Greenberg, Kazuo Fujikawa, Wenfeng Xu, Dominic W. Chung, and Earl W. Davie Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11189–11193. PMCID: PMC18009 Vacuole acidification is required for trans-SNARE pairing, LMA1 release, and homotypic fusion Christian Ungermann, William Wickner, and Zuoyu Xu Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11194–11199. PMCID: PMC18010 Verification of phylogenetic predictions in vivo and the importance of the tetraloop motif in a catalytic RNA Daniel A. Pomeranz Krummel and Sidney Altman Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11200–11205. PMCID: PMC18011 Chitin synthase III: Synthetic lethal mutants and “stress related” chitin synthesis that bypasses the CSD3/CHS6 localization pathway Barbara C. Osmond, Charles A. Specht, and Phillips W. Robbins Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11206–11210. PMCID: PMC18012 De novo amyloid proteins from designed combinatorial libraries Michael W. West, Weixun Wang, Jennifer Patterson, Joseph D. Mancias, James R. Beasley, and Michael H. Hecht Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11211–11216. PMCID: PMC18013 Estrogen induction of the cyclin D1 promoter: Involvement of a cAMP response-like element Michele Sabbah, Delphine Courilleau, Jan Mester, and Gerard Redeuilh Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11217–11222. PMCID: PMC18014 A cooperative oxygen-binding hemoglobin from Mycobacterium tuberculosis Manon Couture, Syun-Ru Yeh, Beatrice A. Wittenberg, Jonathan B. Wittenberg, Yannick Ouellet, Denis L. Rousseau, and Michel Guertin Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11223–11228. PMCID: PMC18015 Quinolone signaling in the cell-to-cell communication system of Pseudomonas aeruginosa Everett C. Pesci, Jared B. J. Milbank, James P. Pearson, Susan McKnight, Andrew S. Kende, E. Peter Greenberg, and Barbara H. Iglewski Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11229–11234. PMCID: PMC18016 Sterols regulate cycling of SREBP cleavage-activating protein (SCAP) between endoplasmic reticulum and Golgi Axel Nohturfft, Russell A. DeBose-Boyd, Sigrid Scheek, Joseph L. Goldstein, and Michael S. Brown Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11235–11240. PMCID: PMC18017 Circular permutation and receptor insertion within green fluorescent proteins Geoffrey S. Baird, David A. Zacharias, and Roger Y. Tsien Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11241–11246. PMCID: PMC18018 Equilibria and kinetics of folding of gelsolin domain 2 and mutants involved in familial amyloidosis–Finnish type Rivka L. Isaacson, Alan G. Weeds, and Alan R. Fersht Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11247–11252. PMCID: PMC18019 Ovochymase, a Xenopus laevis egg extracellular protease, is translated as part of an unusual polyprotease LeAnn L. Lindsay, Joy C. Yang, and Jerry L. Hedrick Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11253–11258. PMCID: PMC18020 The M2–2 protein of human respiratory syncytial virus is a regulatory factor involved in the balance between RNA replication and transcription Alison Bermingham and Peter L. Collins Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11259–11264. PMCID: PMC18021 Biophysics Solution structure of Apaf-1 CARD and its interaction with caspase-9 CARD: A structural basis for specific adaptor/caspase interaction Pei Zhou, James Chou, Roberto Sanchez Olea, Junying Yuan, and Gerhard Wagner Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11265–11270. PMCID: PMC18022 The dynamics of structural deformations of immobilized single light-harvesting complexes Martin A. Bopp, Alexander Sytnik, Tina D. Howard, Richard J. Cogdell, and Robin M. Hochstrasser Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11271–11276. PMCID: PMC18023 Dynamic force spectroscopy of single DNA molecules Torsten Strunz, Krisztina Oroszlan, Rolf Schäfer, and Hans-Joachim Güntherodt Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11277–11282. PMCID: PMC18024 The 28–111 disulfide bond constrains the α-lactalbumin molten globule and weakens its cooperativity of folding Yongzhang Luo and Robert L. Baldwin Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11283–11287. PMCID: PMC18025 Atomic force microscopy captures length phenotypes in single proteins Mariano Carrion-Vazquez, Piotr E. Marszalek, Andres F. Oberhauser, and Julio M. Fernandez Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11288–11292. PMCID: PMC18026 Evidence for the role of PrPC helix 1 in the hydrophilic seeding of prion aggregates M. P. Morrissey and E. I. Shakhnovich Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11293–11298. PMCID: PMC18027 A theoretical search for folding/unfolding nuclei in three-dimensional protein structures Oxana V. Galzitskaya and Alexei V. Finkelstein Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11299–11304. PMCID: PMC18028 Prediction of protein-folding mechanisms from free-energy landscapes derived from native structures E. Alm and D. Baker Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11305–11310. PMCID: PMC18029 A simple model for calculating the kinetics of protein folding from three-dimensional structures Victor Muñoz and William A. Eaton Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11311–11316. PMCID: PMC18030 Cell Biology Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons Christian Gieffers, Beate H. Peters, Edgar R. Kramer, Carlos G. Dotti, and Jan-Michael Peters Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11317–11322. PMCID: PMC18031 Tubulointerstitial nephritis antigen: An extracellular matrix protein that selectively regulates tubulogenesis vs. glomerulogenesis during mammalian renal development Yashpal S. Kanwar, Anil Kumar, Qiwei Yang, Yufeng Tian, Jun Wada, Naoki Kashihara, and Elisabeth I. Wallner Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11323–11328. PMCID: PMC18032 Galectin-7 overexpression is associated with the apoptotic process in UVB-induced sunburn keratinocytes Francoise Bernerd, Alain Sarasin, and Thierry Magnaldo Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11329–11334. PMCID: PMC18033 Mitogen-activated protein kinase kinase activity is required for the G2/M transition of the cell cycle in mammalian fibroblasts Jocelyn H. Wright, Erlynda Munar, Damon R. Jameson, Paul R. Andreassen, Robert L. Margolis, Rony Seger, and Edwin G. Krebs Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11335–11340. PMCID: PMC18034 Phenotypic reversal of the btn1 defects in yeast by chloroquine: A yeast model for Batten disease David A. Pearce, Carrie J. Carr, Biswadip Das, and Fred Sherman Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11341–11345. PMCID: PMC18035 Response tuning in bacterial chemotaxis Ravi Jasuja, Yu-Lin, David R. Trentham, and Shahid Khan Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11346–11351. PMCID: PMC18036 A quantitative analysis of the kinetics of the G2 DNA damage checkpoint system Baltazar D. Aguda Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11352–11357. PMCID: PMC18037 Cholesterol efflux to apolipoprotein AI involves endocytosis and resecretion in a calcium-dependent pathway Yukihiro Takahashi and Jonathan D. Smith Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11358–11363. PMCID: PMC18038 RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination Kevin L. Lorick, Jane P. Jensen, Shengyun Fang, Albert M. Ong, Shigetsugu Hatakeyama, and Allan M. Weissman Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11364–11369. PMCID: PMC18039 Autoproteolysis in nucleoporin biogenesis Jonathan S. Rosenblum and Günter Blobel Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11370–11375. PMCID: PMC18040 Developmental Biology Multiple left-right asymmetry defects in Shh−/− mutant mice unveil a convergence of the Shh and retinoic acid pathways in the control of Lefty-1 Tohru Tsukui, Javier Capdevila, Koji Tamura, Pilar Ruiz-Lozano, Concepción Rodriguez-Esteban, Sayuri Yonei-Tamura, Jorge Magallón, Roshantha A. S. Chandraratna, Kenneth Chien, Bruce Blumberg, Ronald M. Evans, and Juan Carlos Izpisúa Belmonte Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11376–11381. PMCID: PMC18041 Dominant-negative mutation in the β2 and β6 proteasome subunit genes affect alternative cell fate decisions in the Drosophila sense organ lineage François Schweisguth Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11382–11386. PMCID: PMC18042 Ecology Ecosystem rooting depth determined with caves and DNA R. B. Jackson, L. A. Moore, W. A. Hoffmann, W. T. Pockman, and C. R. Linder Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11387–11392. PMCID: PMC18043 Evolution Spontaneous deleterious mutation in Arabidopsis thaliana Stewart T. Schultz, Michael Lynch, and John H. Willis Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11393–11398. PMCID: PMC18044 Genetic and environmental conditions that increase longevity in Caenorhabditis elegans decrease metabolic rate Wayne A. Van Voorhies and Samuel Ward Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11399–11403. PMCID: PMC18045 Genetics Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells A. Kazantsev, E. Preisinger, A. Dranovsky, D. Goldgaber, and D. Housman Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11404–11409. PMCID: PMC18046 Platelet-derived growth factor β receptor regulates interstitial fluid homeostasis through phosphatidylinositol-3′ kinase signaling Rainer Heuchel, Ansgar Berg, Michelle Tallquist, Karina Åhlén, Rolf K. Reed, Kristofer Rubin, Lena Claesson-Welsh, Carl-Henrik Heldin, and Philippe Soriano Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11410–11415. PMCID: PMC18047 The Arabidopsis SKP1-LIKE1 gene is essential for male meiosis and may control homologue separation Ming Yang, Yi Hu, Muhammad Lodhi, W. Richard McCombie, and Hong Ma Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11416–11421. PMCID: PMC18048 Genomic sequence, structural organization, molecular evolution, and aberrant rearrangement of promyelocytic leukemia zinc finger gene T. Zhang, H. Xiong, L.-X. Kan, C.-K. Zhang, X.-F. Jiao, G. Fu, Q.-H. Zhang, L. Lu, J.-H. Tong, B.-W. Gu, M. Yu, J.-X. Liu, J. Licht, S. Waxman, A. Zelent, E. Chen, and S.-J. Chen Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11422–11427. PMCID: PMC18049 Hyperactive transposase mutants of the Himar1 mariner transposon David J. Lampe, Brian J. Akerley, Eric J. Rubin, John J. Mekalanos, and Hugh M. Robertson Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11428–11433. PMCID: PMC18050 Position effect of human telomeric repeats on replication timing R. Ofir, A. C. C. Wong, H. E. McDermid, K. L. Skorecki, and S. Selig Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11434–11439. PMCID: PMC18051 CDC45 and DPB11 are required for processive DNA replication and resistance to DNA topoisomerase I-mediated DNA damage Robert J. D. Reid, Paola Fiorani, Mizuno Sugawara, and Mary-Ann Bjornsti Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11440–11445. PMCID: PMC18052 Immunology Thermodynamics of T cell receptor binding to peptide–MHC: Evidence for a general mechanism of molecular scanning J. Jay Boniface, Ziv Reich, Daniel S. Lyons, and Mark M. Davis Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11446–11451. PMCID: PMC18053 Multiple, targeted deficiencies in selectins reveal a predominant role for P-selectin in leukocyte recruitment Stephen D. Robinson, Paul S. Frenette, Helen Rayburn, Marge Cummiskey, Mollie Ullman-Culleré, Denisa D. Wagner, and Richard O. Hynes Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11452–11457. PMCID: PMC18054 Novel neurotrophin-1/B cell-stimulating factor-3: A cytokine of the IL-6 family Giorgio Senaldi, Brian C. Varnum, Ulla Sarmiento, Charlie Starnes, Jackson Lile, Sheila Scully, Jane Guo, Gary Elliott, Jennifer McNinch, Christine L. Shaklee, Daniel Freeman, Frank Manu, W. Scott Simonet, Thomas Boone, and Ming-Shi Chang Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11458–11463. PMCID: PMC18055 Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia John R. McWhirter, Saskia T. C. Neuteboom, Edward V. Wancewicz, Brett P. Monia, James R. Downing, and Cornelis Murre Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11464–11469. PMCID: PMC18056 Class I MHC molecules on hematopoietic cells can support intrathymic positive selection of T cell receptor transgenic T cells Jens Zerrahn, Ariane Volkmann, Mark C. Coles, Werner Held, Francois A. Lemonnier, and David H. Raulet Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11470–11475. PMCID: PMC18057 In vivo blockade of CTLA-4 enhances the priming of responsive T cells but fails to prevent the induction of tumor antigen-specific tolerance Eduardo M. Sotomayor, Ivan Borrello, Erev Tubb, James P. Allison, and Hyam I. Levitsky Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11476–11481. PMCID: PMC18058 Medical Sciences An anti-CD45RO immunotoxin eliminates T cells latently infected with HIV-1 in vitro Cynthia McCoig, Gregory Van Dyke, Chin-Sheng Chou, Louis J. Picker, Octavio Ramilo, and Ellen S. Vitetta Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11482–11485. PMCID: PMC18059 A putative mechanism of demyelination in multiple sclerosis by a proteolytic enzyme, calpain Donald C. Shields, Kurt E. Schaecher, Takaomi C. Saido, and Naren L. Banik Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11486–11491. PMCID: PMC18060 Deficit of in vivo mitochondrial ATP production in patients with Friedreich ataxia Raffaele Lodi, J. Mark Cooper, Jane L. Bradley, David Manners, Peter Styles, Doris J. Taylor, and Anthony H. V. Schapira Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11492–11495. PMCID: PMC18061 An endothelin receptor B antagonist inhibits growth and induces cell death in human melanoma cells in vitro and in vivo Ronit Lahav, Garrett Heffner, and Paul H. Patterson Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11496–11500. PMCID: PMC18062 Mice without phosphatidylcholine transfer protein have no defects in the secretion of phosphatidylcholine into bile or into lung airspaces Ardy van Helvoort, Arjan de Brouwer, Roelof Ottenhoff, Jos F. H. M. Brouwers, Jan Wijnholds, Jos H. Beijnen, Anita Rijneveld, Tom van der Poll, Martin A. van der Valk, Donné Majoor, Wim Voorhout, Karel W. A. Wirtz, Ronald P. J. Oude Elferink, and Piet Borst Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11501–11506. PMCID: PMC18063 The late phase of ischemic preconditioning is abrogated by targeted disruption of the inducible NO synthase gene Yiru Guo, W. Keith Jones, Yu-Ting Xuan, Xian-Liang Tang, Weike Bao, Wen-Jian Wu, Hui Han, Victor E. Laubach, Peipei Ping, Zequan Yang, Yumin Qiu, and Roberto Bolli Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11507–11512. PMCID: PMC18064 Troglitazone prevents mitochondrial alterations, β cell destruction, and diabetes in obese prediabetic rats Moritake Higa, Yan-Ting Zhou, Mariella Ravazzola, Danielle Baetens, Lelio Orci, and Roger H. Unger Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11513–11518. PMCID: PMC18065 Detection of human neurotropic JC virus DNA sequence and expression of the viral oncogenic protein in pediatric medulloblastomas Barbara Krynska, Luis Del Valle, Sidney Croul, Jennifer Gordon, Christos D. Katsetos, Michele Carbone, Antonio Giordano, and Kamel Khalili Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11519–11524. PMCID: PMC18066 3-Hydroxy-3-methylglutaryl CoA reductase inhibitors up-regulate transforming growth factor-β signaling in cultured heart cells via inhibition of geranylgeranylation of RhoA GTPase Ho-Jin Park and Jonas B. Galper Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11525–11530. PMCID: PMC18067 Soluble member(s) of the mesothelin/megakaryocyte potentiating factor family are detectable in sera from patients with ovarian carcinoma Nathalie Scholler, Ning Fu, Yi Yang, Zhengmao Ye, Gary E. Goodman, Karl Erik Hellström, and Ingegerd Hellström Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11531–11536. PMCID: PMC18068 IL-18 binding and inhibition of interferon γ induction by human poxvirus-encoded proteins Yan Xiang and Bernard Moss Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11537–11542. PMCID: PMC18069 Lpsd/Ran of endotoxin-resistant C3H/HeJ mice is defective in mediating lipopolysaccharide endotoxin responses Peter M. C. Wong, Anthony Kang, Hong Chen, Quan Yuan, Peidong Fan, Barnet M. Sultzer, Yuet Wai Kan, and Siu-Wah Chung Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11543–11548. PMCID: PMC18070 A simple relationship between viral load and survival time in HIV-1 infection Ramy A. Arnaout, Alun L. Lloyd, Thomas R. O’Brien, James J. Goedert, John M. Leonard, and Martin A. Nowak Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11549–11553. PMCID: PMC18071 Microbiology Identification of Mycobacterium tuberculosis RNAs synthesized in response to phagocytosis by human macrophages by selective capture of transcribed sequences (SCOTS) James E. Graham and Josephine E. Clark-Curtiss Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11554–11559. PMCID: PMC18072 A coding RNA sequence acts as a replication signal in cardioviruses Pierre-Emmanuel Lobert, Nicolas Escriou, Jean Ruelle, and Thomas Michiels Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11560–11565. PMCID: PMC18073 Three unrelated viral transforming proteins (vIRF, EBNA2, and E1A) induce the MYC oncogene through the interferon-responsive PRF element by using different transcription coadaptors Sukhanya Jayachandra, Kenneth G. Low, Ai-En Thlick, Jin Yu, Paul D. Ling, Yuan Chang, and Patrick S. Moore Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11566–11571. PMCID: PMC18074 Association of HIV-1 Tat with the cellular protein, Purα, is mediated by RNA Gary L. Gallia, Nune Darbinian, Anna Tretiakova, Sameer A. Ansari, Jay Rappaport, John Brady, Margaret J. Wortman, Edward M. Johnson, and Kamel Khalili Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11572–11577. PMCID: PMC18075 DNA adenine methylase mutants of Salmonella typhimurium show defects in protein secretion, cell invasion, and M cell cytotoxicity Francisco García-Del Portillo, M. Graciela Pucciarelli, and Josep Casadesús Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11578–11583. PMCID: PMC18076 Titanospirillum velox: A huge, speedy, sulfur-storing spirillum from Ebro Delta microbial mats Ricardo Guerrero, Aaron Haselton, Mónica Solé, Andrew Wier, and Lynn Margulis Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11584–11588. PMCID: PMC18077 Neurobiology Slow transport of unpolymerized tubulin and polymerized neurofilament in the squid giant axon James A. Galbraith, Thomas S. Reese, Michelle L. Schlief, and Paul E. Gallant Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11589–11594. PMCID: PMC18078 Altered anxiety and weight gain in corticotropin-releasing hormone-binding protein-deficient mice I. Jill Karolyi, Heather L. Burrows, Tennore M. Ramesh, Masaharu Nakajima, J. Shonee Lesh, Eunju Seong, Sally A. Camper, and Audrey F. Seasholtz Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11595–11600. PMCID: PMC18079 Distinctive compartmental organization of human primary visual cortex Todd M. Preuss, Huixin Qi, and Jon H. Kaas Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11601–11606. PMCID: PMC18080 D2 dopamine receptors induce mitogen-activated protein kinase and cAMP response element-binding protein phosphorylation in neurons Zhen Yan, Jian Feng, Allen A. Fienberg, and Paul Greengard Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11607–11612. PMCID: PMC18081 IL-1β differentially regulates calcium wave propagation between primary human fetal astrocytes via pathways involving P2 receptors and gap junction channels Gareth R. John, Eliana Scemes, Sylvia O. Suadicani, Judy S. H. Liu, Peter C. Charles, Sunhee C. Lee, David C. Spray, and Celia F. Brosnan Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11613–11618. PMCID: PMC18082 Regeneration of a germinal layer in the adult mammalian brain Fiona Doetsch, Jose Manuel García-Verdugo, and Arturo Alvarez-Buylla Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11619–11624. PMCID: PMC18083 Central representation of time during motor learning Michael A. Conditt and Ferdinando A. Mussa-Ivaldi Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11625–11630. PMCID: PMC18084 Selective glutamate receptor antagonists can induce or prevent axonal sprouting in rat hippocampal slice cultures R. Anne McKinney, Andreas Lüthi, Christine E. Bandtlow, Beat H. Gähwiler, and Scott M. Thompson Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11631–11636. PMCID: PMC18085 The unseen color aftereffect of an unseen stimulus: Insight from blindsight into mechanisms of color afterimages John L. Barbur, Lawrence Weiskrantz, and J. Alister Harlow Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11637–11641. PMCID: PMC18086 Basolateral amygdala noradrenergic influence enables enhancement of memory consolidation induced by hippocampal glucocorticoid receptor activation Benno Roozendaal, Bichngoc T. Nguyen, Ann E. Power, and James L. McGaugh Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11642–11647. PMCID: PMC18087 Pharmacology Gene transfer of endothelial nitric oxide synthase to the penis augments erectile responses in the aged rat H. C. Champion, T. J. Bivalacqua, A. L. Hyman, L. J. Ignarro, W. J. G. Hellstrom, and P. J. Kadowitz Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11648–11652. PMCID: PMC18088 Physiology Neutral endopeptidase (EC 3.4.24.11) terminates colitis by degrading substance P S. Sturiale, G. Barbara, B. Qiu, M. Figini, P. Geppetti, N. Gerard, C. Gerard, E. F. Grady, N. W. Bunnett, and S. M. Collins Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11653–11658. PMCID: PMC18089 Plant Biology Different circadian oscillators control Ca2+ fluxes and Lhcb gene expression Jiqing Sai and Carl Hirschie Johnson Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11659–11663. PMCID: PMC18090 Molecular analysis of NOZZLE, a gene involved in pattern formation and early sporogenesis during sex organ development in Arabidopsis thaliana Ursula Schiefthaler, Sureshkumar Balasubramanian, Patrick Sieber, David Chevalier, Ellen Wisman, and Kay Schneitz Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11664–11669. PMCID: PMC18091 Genomic context influences the activity of maize mitochondrial cox2 promoters D. Shelley Lupold, Angelina G. F. S. Caoile, and David B. Stern Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11670–11675. PMCID: PMC18092 Antisense-mediated silencing of a gene encoding a major ryegrass pollen allergen Prem L. Bhalla, Ines Swoboda, and Mohan B. Singh Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11676–11680. PMCID: PMC18093 Psychology Measuring the amplification of attention Erik Blaser, George Sperling, and Zhong-Lin Lu Proc Natl Acad Sci U S A. 1999 September 28; 96(20): 11681–11686. PMCID: PMC18094 |