| | This journal provides immediate access to some articles. In This Issue Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3525–3526. doi: 10.1073/iti1005102.PMCID: PMC553343 Commentaries Powerful screens for bacterial virulence proteins Kinya Nomura and Sheng Yang He Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3527–3528. Published online 2005 February 28. doi: 10.1073/pnas.0500724102.PMCID: PMC553340 Time for chronotherapy? Clock genes dictate sensitivity to cyclophosphamide Carla B. Green Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3529–3530. Published online 2005 February 28. doi: 10.1073/pnas.0500552102.PMCID: PMC553324 Mechanism-derived gene expression signatures and predictive biomarkers in clinical oncology Edison T. Liu Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3531–3532. Published online 2005 February 28. doi: 10.1073/pnas.0500244102.PMCID: PMC553302 Long-Range Electron Transfer Special Feature Introduction Distant charge transport Harry B. Gray and Jack Halpern Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3533. Published online 2005 February 28. doi: 10.1073/pnas.0501035102.PMCID: PMC553342 Perspective Long-range electron transfer Harry B. Gray and Jay R. Winkler Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3534–3539. Published online 2005 February 28. doi: 10.1073/pnas.0408029102.PMCID: PMC553296 Long-Range Electron Transfer Special Feature: Wire-like charge transport at near constant bridge energy through fluorene oligomers Randall H. Goldsmith, Louise E. Sinks, Richard F. Kelley, Laura J. Betzen, Wenhao Liu, Emily A. Weiss, Mark A. Ratner, and Michael R. Wasielewski Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3540–3545. Published online 2005 February 28. doi: 10.1073/pnas.0408940102.PMCID: PMC553316 From the Cover: Long-Range Electron Transfer Special Feature: Protein–DNA charge transport: Redox activation of a DNA repair protein by guanine radical Eylon Yavin, Amie K. Boal, Eric D. A. Stemp, Elizabeth M. Boon, Alison L. Livingston, Valerie L. O'Shea, Sheila S. David, and Jacqueline K. Barton Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3546–3551. Published online 2005 February 28. doi: 10.1073/pnas.0409410102.PMCID: PMC553321 Long-Range Electron Transfer Special Feature: Protein dynamics and electron transfer: Electronic decoherence and non-Condon effects Spiros S. Skourtis, Ilya A. Balabin, Tsutomu Kawatsu, and David N. Beratan Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3552–3557. Published online 2005 February 28. doi: 10.1073/pnas.0409047102.PMCID: PMC553344 Long-Range Electron Transfer Special Feature: Interprotein electron transfer from cytochrome c2 to photosynthetic reaction center: Tunneling across an aqueous interface Osamu Miyashita, Melvin Y. Okamura, and José N. Onuchic Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3558–3563. Published online 2005 February 28. doi: 10.1073/pnas.0409600102.PMCID: PMC553326 Long-Range Electron Transfer Special Feature: Differential influence of dynamic processes on forward and reverse electron transfer across a protein-protein interface Brian M. Hoffman, Laura M. Celis, Deborah A. Cull, Ami D. Patel, Jennifer L. Seifert, Korin E. Wheeler, Jingyun Wang, Jiang Yao, Igor V. Kurnikov, and Judith M. Nocek Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3564–3569. Published online 2005 February 28. doi: 10.1073/pnas.0408767102.PMCID: PMC553314 Physical Sciences Chemistry Long-Range Electron Transfer Special Feature: Wire-like charge transport at near constant bridge energy through fluorene oligomers Randall H. Goldsmith, Louise E. Sinks, Richard F. Kelley, Laura J. Betzen, Wenhao Liu, Emily A. Weiss, Mark A. Ratner, and Michael R. Wasielewski Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3540–3545. Published online 2005 February 28. doi: 10.1073/pnas.0408940102.PMCID: PMC553316 From the Cover: Long-Range Electron Transfer Special Feature: Protein–DNA charge transport: Redox activation of a DNA repair protein by guanine radical Eylon Yavin, Amie K. Boal, Eric D. A. Stemp, Elizabeth M. Boon, Alison L. Livingston, Valerie L. O'Shea, Sheila S. David, and Jacqueline K. Barton Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3546–3551. Published online 2005 February 28. doi: 10.1073/pnas.0409410102.PMCID: PMC553321 Long-Range Electron Transfer Special Feature: Protein dynamics and electron transfer: Electronic decoherence and non-Condon effects Spiros S. Skourtis, Ilya A. Balabin, Tsutomu Kawatsu, and David N. Beratan Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3552–3557. Published online 2005 February 28. doi: 10.1073/pnas.0409047102.PMCID: PMC553344 Long-Range Electron Transfer Special Feature: Interprotein electron transfer from cytochrome c2 to photosynthetic reaction center: Tunneling across an aqueous interface Osamu Miyashita, Melvin Y. Okamura, and José N. Onuchic Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3558–3563. Published online 2005 February 28. doi: 10.1073/pnas.0409600102.PMCID: PMC553326 Long-Range Electron Transfer Special Feature: Differential influence of dynamic processes on forward and reverse electron transfer across a protein-protein interface Brian M. Hoffman, Laura M. Celis, Deborah A. Cull, Ami D. Patel, Jennifer L. Seifert, Korin E. Wheeler, Jingyun Wang, Jiang Yao, Igor V. Kurnikov, and Judith M. Nocek Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3564–3569. Published online 2005 February 28. doi: 10.1073/pnas.0408767102.PMCID: PMC553314 A remarkably effective copper(II)-dipyridylphosphine catalyst system for the asymmetric hydrosilylation of ketones in air Jing Wu, Jian-Xin Ji, and Albert S. C. Chan Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3570–3575. Published online 2005 February 22. doi: 10.1073/pnas.0409043102.PMCID: PMC553317 Chemical genomic profiling to identify intracellular targets of a multiplex kinase inhibitor Charles Kung, Denise M. Kenski, Scott H. Dickerson, Russell W. Howson, Lee F. Kuyper, Hiten D. Madhani, and Kevan M. Shokat Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3587–3592. Published online 2005 February 28. doi: 10.1073/pnas.0407170102.PMCID: PMC552777 Biological Sciences Anthropology Reciprocal evolution of the cerebellum and neocortex in fossil humans Anne H. Weaver Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3576–3580. Published online 2005 February 24. doi: 10.1073/pnas.0500692102.PMCID: PMC553338 Applied Biological Sciences Ultrasensitivity and noise propagation in a synthetic transcriptional cascade Sara Hooshangi, Stephan Thiberge, and Ron Weiss Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3581–3586. Published online 2005 February 28. doi: 10.1073/pnas.0408507102.PMCID: PMC552778 Biochemistry From the Cover: Long-Range Electron Transfer Special Feature: Protein–DNA charge transport: Redox activation of a DNA repair protein by guanine radical Eylon Yavin, Amie K. Boal, Eric D. A. Stemp, Elizabeth M. Boon, Alison L. Livingston, Valerie L. O'Shea, Sheila S. David, and Jacqueline K. Barton Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3546–3551. Published online 2005 February 28. doi: 10.1073/pnas.0409410102.PMCID: PMC553321 Chemical genomic profiling to identify intracellular targets of a multiplex kinase inhibitor Charles Kung, Denise M. Kenski, Scott H. Dickerson, Russell W. Howson, Lee F. Kuyper, Hiten D. Madhani, and Kevan M. Shokat Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3587–3592. Published online 2005 February 28. doi: 10.1073/pnas.0407170102.PMCID: PMC552777 Delineation of a unique protein–protein interaction site on the surface of the estrogen receptor Eric H. Kong, Nina Heldring, Jan-Åke Gustafsson, Eckardt Treuter, Roderick E. Hubbard, and Ashley C. W. Pike Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3593–3598. Published online 2005 February 23. doi: 10.1073/pnas.0407189102.PMCID: PMC553308 Structural and mechanistic analysis of two prolyl endopeptidases: Role of interdomain dynamics in catalysis and specificity Lu Shan, Irimpan I. Mathews, and Chaitan Khosla Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3599–3604. Published online 2005 February 28. doi: 10.1073/pnas.0408286102.PMCID: PMC553306 Regulation of heterogenous nuclear ribonucleoprotein A1 transport by phosphorylation in cells stressed by osmotic shock Eric Allemand, Sònia Guil, Michael Myers, Jorge Moscat, Javier F. Cáceres, and Adrian R. Krainer Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3605–3610. Published online 2005 February 28. doi: 10.1073/pnas.0409889102.PMCID: PMC553333 Regulation of coactivator complex assembly and function by protein arginine methylation and demethylimination Young-Ho Lee, Scott A. Coonrod, W. Lee Kraus, Mary Anne Jelinek, and Michael R. Stallcup Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3611–3616. Published online 2005 February 24. doi: 10.1073/pnas.0407159102.PMCID: PMC553305 A bifunctional DNA repair protein from Ferroplasma acidarmanus exhibits O6-alkylguanine-DNA alkyltransferase and endonuclease V activities Sreenivas Kanugula, Gary T. Pauly, Robert C. Moschel, and Anthony E. Pegg Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3617–3622. Published online 2005 February 24. doi: 10.1073/pnas.0408719102.PMCID: PMC553313 Architecture of the bacteriophage T4 primosome: Electron microscopy studies of helicase (gp41) and primase (gp61) Mona T. Norcum, J. Anthony Warrington, Michelle M. Spiering, Faoud T. Ishmael, Michael A. Trakselis, and Stephen J. Benkovic Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3623–3626. Published online 2005 February 28. doi: 10.1073/pnas.0500713102.PMCID: PMC553339 Accumulation of miR-155 and BIC RNA in human B cell lymphomas Peggy S. Eis, Wayne Tam, Liping Sun, Amy Chadburn, Zongdong Li, Mario F. Gomez, Elsebet Lund, and James E. Dahlberg Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3627–3632. Published online 2005 February 28. doi: 10.1073/pnas.0500613102.PMCID: PMC552785 Biophysics Long-Range Electron Transfer Special Feature: Protein dynamics and electron transfer: Electronic decoherence and non-Condon effects Spiros S. Skourtis, Ilya A. Balabin, Tsutomu Kawatsu, and David N. Beratan Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3552–3557. Published online 2005 February 28. doi: 10.1073/pnas.0409047102.PMCID: PMC553344 Long-Range Electron Transfer Special Feature: Interprotein electron transfer from cytochrome c2 to photosynthetic reaction center: Tunneling across an aqueous interface Osamu Miyashita, Melvin Y. Okamura, and José N. Onuchic Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3558–3563. Published online 2005 February 28. doi: 10.1073/pnas.0409600102.PMCID: PMC553326 Long-Range Electron Transfer Special Feature: Differential influence of dynamic processes on forward and reverse electron transfer across a protein-protein interface Brian M. Hoffman, Laura M. Celis, Deborah A. Cull, Ami D. Patel, Jennifer L. Seifert, Korin E. Wheeler, Jingyun Wang, Jiang Yao, Igor V. Kurnikov, and Judith M. Nocek Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3564–3569. Published online 2005 February 28. doi: 10.1073/pnas.0408767102.PMCID: PMC553314 Proton binding within a membrane protein by a protonated water cluster Florian Garczarek, Leonid S. Brown, Janos K. Lanyi, and Klaus Gerwert Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3633–3638. Published online 2005 February 28. doi: 10.1073/pnas.0500421102.PMCID: PMC553315 Small-molecule-mediated stabilization of familial amyotrophic lateral sclerosis-linked superoxide dismutase mutants against unfolding and aggregation Soumya S. Ray, Richard J. Nowak, Robert H. Brown, Jr., and Peter T. Lansbury, Jr. Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3639–3644. Published online 2005 February 28. doi: 10.1073/pnas.0408277102.PMCID: PMC553303 DNA twisting flexibility and the formation of sharply looped protein–DNA complexes T. E. Cloutier and J. Widom Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3645–3650. Published online 2005 February 17. doi: 10.1073/pnas.0409059102.PMCID: PMC553319 From the Cover: Global mapping of the protein structure space and application in structure-based inference of protein function Jingtong Hou, Se-Ran Jun, Chao Zhang, and Sung-Hou Kim Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3651–3656. Published online 2005 February 10. doi: 10.1073/pnas.0409772102.PMCID: PMC548596 Time-resolved electrometric and optical studies on cytochrome bd suggest a mechanism of electron-proton coupling in the di-heme active site Ilya Belevich, Vitaliy B. Borisov, Jie Zhang, Ke Yang, Alexander A. Konstantinov, Robert B. Gennis, and Michael I. Verkhovsky Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3657–3662. Published online 2005 February 22. doi: 10.1073/pnas.0405683102.PMCID: PMC553295 DNA coiled coils J. L. Campos, L. Urpí, T. Sanmartín, C. Gouyette, and J. A. Subirana Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3663–3666. Published online 2005 February 22. doi: 10.1073/pnas.0500496102.PMCID: PMC553320 Three-dimensional reconstruction of the dynactin complex by single-particle image analysis J. L. Hodgkinson, C. Peters, S. A. Kuznetsov, and W. Steffen Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3667–3672. Published online 2005 February 28. doi: 10.1073/pnas.0409506102.PMCID: PMC553325 Structural polymorphism of the cytoskeleton: A model of linker-assisted filament aggregation Itamar Borukhov, Robijn F. Bruinsma, William M. Gelbart, and Andrea J. Liu Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3673–3678. Published online 2005 February 24. doi: 10.1073/pnas.0404140102.PMCID: PMC553289 Cell Biology Disrupting integrin transmembrane domain heterodimerization increases ligand binding affinity, not valency or clustering Bing-Hao Luo, Christopher V. Carman, Junichi Takagi, and Timothy A. Springer Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3679–3684. Published online 2005 February 28. doi: 10.1073/pnas.0409440102.PMCID: PMC553322 Matrix metalloproteinase 13 mediates nitric oxide activation of endothelial cell migration Esther López-Rivera, Tania R. Lizarbe, Mónica Martínez-Moreno, José Miguel López-Novoa, Alicia Rodríguez-Barbero, José Rodrigo, Ana Patricia Fernández, Alberto Álvarez-Barrientos, Santiago Lamas, and Carlos Zaragoza Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3685–3690. Published online 2005 February 22. doi: 10.1073/pnas.0408217102.PMCID: PMC553299 Nuclear processing and export of microRNAs in Arabidopsis Mee Yeon Park, Gang Wu, Alfredo Gonzalez-Sulser, Hervé Vaucheret, and R. Scott Poethig Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3691–3696. Published online 2005 February 28. doi: 10.1073/pnas.0405570102.PMCID: PMC553294 Identification and functional significance of genes regulated by structurally different histone deacetylase inhibitors Melissa J. Peart, Gordon K. Smyth, Ryan K. van Laar, David D. Bowtell, Victoria M. Richon, Paul A. Marks, Andrew J. Holloway, and Ricky W. Johnstone Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3697–3702. Published online 2005 February 28. doi: 10.1073/pnas.0500369102.PMCID: PMC552783 Genome-wide transcriptional analysis of flagellar regeneration in Chlamydomonas reinhardtii identifies orthologs of ciliary disease genes Viktor Stolc, Manoj Pratim Samanta, Waraporn Tongprasit, and Wallace F. Marshall Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3703–3707. Published online 2005 February 28. doi: 10.1073/pnas.0408358102.PMCID: PMC553310 Developmental Biology Barx2 functions through distinct corepressor classes to regulate hair follicle remodeling Lorin E. Olson, Jie Zhang, Havilah Taylor, David W. Rose, and Michael G. Rosenfeld Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3708–3713. Published online 2005 February 22. doi: 10.1073/pnas.0500519102.PMCID: PMC553323 Transdifferentiation of corneal epithelium into epidermis occurs by means of a multistep process triggered by dermal developmental signals David J. Pearton, Ying Yang, and Danielle Dhouailly Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3714–3719. Published online 2005 February 28. doi: 10.1073/pnas.0500344102.PMCID: PMC553311 Remodeling of the intestine during metamorphosis of Xenopus laevis Alex M. Schreiber, Liquan Cai, and Donald D. Brown Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3720–3725. Published online 2005 February 28. doi: 10.1073/pnas.0409868102.PMCID: PMC553331 Ecology Extinction dynamics in experimental metapopulations Jane Molofsky and Jean-Baptiste Ferdy Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3726–3731. Published online 2005 February 28. doi: 10.1073/pnas.0404576102.PMCID: PMC553292 Evolution Termites assess wood size by using vibration signals Theodore A. Evans, Joseph C. S. Lai, Emilie Toledano, Lee McDowall, Sandrine Rakotonarivo, and Michael Lenz Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3732–3737. Published online 2005 February 25. doi: 10.1073/pnas.0408649102.PMCID: PMC553312 Genetics From the Cover: Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival Howard Y. Chang, Dimitry S. A. Nuyten, Julie B. Sneddon, Trevor Hastie, Robert Tibshirani, Therese Sørlie, Hongyue Dai, Yudong D. He, Laura J. van't Veer, Harry Bartelink, Matt van de Rijn, Patrick O. Brown, and Marc J. van de Vijver Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3738–3743. Published online 2005 February 8. doi: 10.1073/pnas.0409462102.PMCID: PMC548329 Immunology HLA-restricted epitope identification and detection of functional T cell responses by using MHC–peptide and costimulatory microarrays Jennifer D. Stone, Walter E. Demkowicz, Jr., and Lawrence J. Stern Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3744–3749. Published online 2005 February 23. doi: 10.1073/pnas.0407019102.PMCID: PMC553304 From the Cover: Expression of an additional cathelicidin antimicrobial peptide protects against bacterial skin infection Phillip H. A. Lee, Takaaki Ohtake, Mohamed Zaiou, Masamoto Murakami, Jennifer A. Rudisill, Kenneth H. Lin, and Richard L. Gallo Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3750–3755. Published online 2005 February 22. doi: 10.1073/pnas.0500268102.PMCID: PMC549293 Culturing at atmospheric oxygen levels impacts lymphocyte function Kondala R. Atkuri, Leonard A. Herzenberg, and Leonore A. Herzenberg Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3756–3759. Published online 2005 February 28. doi: 10.1073/pnas.0409910102.PMCID: PMC553335 Medical Sciences A mouse model for study of systemic HIV-1 infection, antiviral immune responses, and neuroinvasiveness Mary Jane Potash, Wei Chao, Galina Bentsman, Nicolae Paris, Manisha Saini, Jadwiga Nitkiewicz, Paula Belem, Leroy Sharer, Andrew I. Brooks, and David J. Volsky Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3760–3765. Published online 2005 February 23. doi: 10.1073/pnas.0500649102.PMCID: PMC553332 Cardiac stem cells delivered intravascularly traverse the vessel barrier, regenerate infarcted myocardium, and improve cardiac function Buddhadeb Dawn, Adam B. Stein, Konrad Urbanek, Marcello Rota, Brian Whang, Raffaella Rastaldo, Daniele Torella, Xian-Liang Tang, Arash Rezazadeh, Jan Kajstura, Annarosa Leri, Greg Hunt, Jai Varma, Sumanth D. Prabhu, Piero Anversa, and Roberto Bolli Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3766–3771. Published online 2005 February 25. doi: 10.1073/pnas.0405957102.PMCID: PMC553298 Synthetic analogues of migrastatin that inhibit mammary tumor metastasis in mice Dandan Shan, Lin Chen, Jon T. Njardarson, Christoph Gaul, Xiaojing Ma, Samuel J. Danishefsky, and Xin-Yun Huang Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3772–3776. Published online 2005 February 22. doi: 10.1073/pnas.0500658102.PMCID: PMC553334 Identification of combinatorial drug regimens for treatment of Huntington's disease using Drosophila Namita Agrawal, Judit Pallos, Natalia Slepko, Barbara L. Apostol, Laszlo Bodai, Ling-Wen Chang, Ann-Shyn Chiang, Leslie Michels Thompson, and J. Lawrence Marsh Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3777–3781. Published online 2005 February 16. doi: 10.1073/pnas.0500055102.PMCID: PMC553288 Regulation of platelet granule exocytosis by S-nitrosylation Craig N. Morrell, Kenji Matsushita, Kelly Chiles, Robert B. Scharpf, Munekazu Yamakuchi, Rebecca J. A. Mason, Wolfgang Bergmeier, Joseph L. Mankowski, William M. Baldwin, III, Nauder Faraday, and Charles J. Lowenstein Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3782–3787. Published online 2005 February 28. doi: 10.1073/pnas.0408310102.PMCID: PMC553307 ErbB-3 mediates phosphoinositide 3-kinase activity in gefitinib-sensitive non-small cell lung cancer cell lines Jeffrey A. Engelman, Pasi A. Jänne, Craig Mermel, Joseph Pearlberg, Toru Mukohara, Christina Fleet, Karen Cichowski, Bruce E. Johnson, and Lewis C. Cantley Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3788–3793. Published online 2005 February 24. doi: 10.1073/pnas.0409773102.PMCID: PMC553328 Microbiology The CD4 molecule on CD8+ T lymphocytes directly enhances the immune response to viral and cellular antigens Scott G. Kitchen, Jason K. Whitmire, Nicole R. Jones, Zoran Galic, Christina M. R. Kitchen, Rafi Ahmed, and Jerome A. Zack Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3794–3799. Published online 2005 February 24. doi: 10.1073/pnas.0406603102.PMCID: PMC553300 Microsatellite instability regulates transcription factor binding and gene expression Patricia Martin, Katherine Makepeace, Stuart A. Hill, Derek W. Hood, and E. Richard Moxon Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3800–3804. Published online 2005 February 22. doi: 10.1073/pnas.0406805102.PMCID: PMC553301 Identification of viral genes essential for replication of murine γ-herpesvirus 68 using signature-tagged mutagenesis Moon Jung Song, Seungmin Hwang, Wendy H. Wong, Ting-Ting Wu, Sangmi Lee, Hsiang-I Liao, and Ren Sun Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3805–3810. Published online 2005 February 28. doi: 10.1073/pnas.0404521102.PMCID: PMC553290 Neuroscience Intranasal administration of nerve growth factor (NGF) rescues recognition memory deficits in AD11 anti-NGF transgenic mice Roberta De Rosa, Addys Ancheta Garcia, Chiara Braschi, Simona Capsoni, Lamberto Maffei, Nicoletta Berardi, and Antonino Cattaneo Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3811–3816. Published online 2005 February 23. doi: 10.1073/pnas.0500195102.PMCID: PMC553297 From the Cover: Perinatal exposure to nicotine causes deficits associated with a loss of nicotinic receptor function Gary Cohen, Jean-Christophe Roux, Régis Grailhe, Girvan Malcolm, Jean-Pierre Changeux, and Hugo Lagercrantz Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3817–3821. Published online 2005 February 28. doi: 10.1073/pnas.0409782102.PMCID: PMC552781 Coupling of the cortical hemodynamic response to cortical and thalamic neuronal activity Anna Devor, Istvan Ulbert, Andrew K. Dunn, Suresh N. Narayanan, Stephanie R. Jones, Mark L. Andermann, David A. Boas, and Anders M. Dale Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3822–3827. Published online 2005 February 25. doi: 10.1073/pnas.0407789102.PMCID: PMC550644 Inhibition of NUDEL (nuclear distribution element-like)-oligopeptidase activity by disrupted-in-schizophrenia 1 Mirian A. F. Hayashi, Fernanda C. V. Portaro, Marta F. Bastos, Juliano R. Guerreiro, Vitor Oliveira, Silvia S. Gorrão, Denise V. Tambourgi, Osvaldo A. Sant'Anna, Paul J. Whiting, L. Miguel Camargo, Katsuhiro Konno, Nicholas J. Brandon, and Antonio C. M. Camargo Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3828–3833. Published online 2005 February 23. doi: 10.1073/pnas.0500330102.PMCID: PMC553309 Function and regulation of Tumbleweed (RacGAP50C) in neuroblast proliferation and neuronal morphogenesis Ann Y. N. Goldstein, Yuh-Nung Jan, and Liqun Luo Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3834–3839. Published online 2005 February 28. doi: 10.1073/pnas.0500748102.PMCID: PMC553341 Automated microscope system for determining factors that predict neuronal fate Montserrat Arrasate and Steven Finkbeiner Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3840–3845. Published online 2005 February 28. doi: 10.1073/pnas.0409777102.PMCID: PMC553329 Loss of mitogen-activated protein kinase kinase kinase 4 (MEKK4) results in enhanced apoptosis and defective neural tube development Hongbo Chi, Matthew R. Sarkisian, Pasko Rakic, and Richard A. Flavell Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3846–3851. Published online 2005 February 24. doi: 10.1073/pnas.0500026102.PMCID: PMC553336 Seeing the light: Illumination as a contextual cue to color choice behavior in bumblebees R. Beau Lotto and Lars Chittka Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3852–3856. Published online 2005 February 24. doi: 10.1073/pnas.0500681102.PMCID: PMC553337 Inactivation of liver X receptor β leads to adult-onset motor neuron degeneration in male mice Sandra Andersson, Nina Gustafsson, Margaret Warner, and Jan-Åke Gustafsson Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3857–3862. Published online 2005 February 28. doi: 10.1073/pnas.0500634102.PMCID: PMC553330 Theta oscillations and sensorimotor performance Leslie M. Kay Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3863–3868. Published online 2005 February 28. doi: 10.1073/pnas.0407920102.PMCID: PMC553293 Cortical processing of a brightness illusion Anna Wang Roe, Haidong D. Lu, and Chou P. Hung Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3869–3874. Published online 2005 February 28. doi: 10.1073/pnas.0500097102.PMCID: PMC552782 Physiology Evidence from renal proximal tubules that and solute reabsorption are acutely regulated not by pH but by basolateral and CO 2Yuehan Zhou, Jinhua Zhao, Patrice Bouyer, and Walter F. Boron Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3875–3880. Published online 2005 February 22. doi: 10.1073/pnas.0500423102.PMCID: PMC553318 Psychology The time course and specificity of perceptual deterioration Sara C. Mednick, A. Cyrus Arman, and Geoffrey M. Boynton Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3881–3885. Published online 2005 February 24. doi: 10.1073/pnas.0407866102.PMCID: PMC553291 Correction Proc Natl Acad Sci U S A. 2005 March 8; 102(10): 3886. Published online 2005 February 23. doi: 10.1073/pnas.0500609102.PMCID: PMC553327 Corrects: Eric Gelhaye, et al. A specific form of thioredoxin h occurs in plant mitochondria and regulates the alternative oxidase. Proc Natl Acad Sci U S A. 2004 October 5; 101(40): 14545–14550. |