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Volume 98(23);  November 6, 2001
From the Academy
U.S. Frontiers Of Science Symposium
Introduction to Frontiers of Science
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12869. Published online 2001 October 30. doi: 10.1073/pnas.241391198.
PMCID: PMC60787
Surface molecular recognition
Nicole S. Sampson, Milan Mrksich, and Carolyn R. Bertozzi
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12870–12871. Published online 2001 October 30. doi: 10.1073/pnas.231391398.
PMCID: PMC60788
Mathematical frontiers in optical solitons
Jared C. Bronski, Mordechai Segev, and Michael I. Weinstein
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12872–12873. Published online 2001 October 30. doi: 10.1073/pnas.231499298.
PMCID: PMC60789
The acquisition of language by children
Jenny R. Saffran, Ann Senghas, and John C. Trueswell
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12874–12875. Published online 2001 October 30. doi: 10.1073/pnas.231498898.
PMCID: PMC60790
The North Atlantic Oscillation: Past, present, and future
Martin H. Visbeck, James W. Hurrell, Lorenzo Polvani, and Heidi M. Cullen
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12876–12877. Published online 2001 October 30. doi: 10.1073/pnas.231391598.
PMCID: PMC60791
Commentaries
Peptide signaling in plants
Henk J. Franssen and Ton Bisseling
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12855–12856. doi: 10.1073/pnas.231490798.
PMCID: PMC60782
Sex roles, ornaments, and evolutionary explanation
Anne E. Houde
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12857–12859. doi: 10.1073/pnas.241503598.
PMCID: PMC60783
DNA repair on the brain
R. R. Laposa and J. E. Cleaver
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12860–12862. doi: 10.1073/pnas.241519498.
PMCID: PMC60784
Homemade cofactors: Self-processing in galactose oxidase
Lili Xie and Wilfred A. van der Donk
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12863–12865. doi: 10.1073/pnas.231485998.
PMCID: PMC60785
Unleashing yeast genetics on a factor-independent mechanism of internal translation initiation
Alan G. Hinnebusch
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12866–12868. doi: 10.1073/pnas.241517998.
PMCID: PMC60786
Physical Sciences
Applied Mathematics
Self-similar intermediate asymptotics for nonlinear degenerate parabolic free-boundary problems that occur in image processing
G. I. Barenblatt
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12878–12881. Published online 2001 October 23. doi: 10.1073/pnas.241501698.
PMCID: PMC60792
Mathematics
From the Cover:
Congruence properties for the partition function
Scott Ahlgren and Ken Ono
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12882–12884. Published online 2001 October 23. doi: 10.1073/pnas.191488598.
PMCID: PMC60793
Biological Sciences
Agricultural Sciences
A phylogenetic approach to following West Nile virus in Connecticut
John F. Anderson, Charles R. Vossbrinck, Theodore G. Andreadis, Anthony Iton, William H. Beckwith, III, and Donald R. Mayo
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12885–12889. Published online 2001 October 23. doi: 10.1073/pnas.241472398.
PMCID: PMC60794
Anthropology
Paternity and relatedness in wild chimpanzee communities
Linda Vigilant, Michael Hofreiter, Heike Siedel, and Christophe Boesch
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12890–12895. Published online 2001 October 23. doi: 10.1073/pnas.231320498.
PMCID: PMC60795
Biochemistry
Structural genomics of enzymes involved in sterol/isoprenoid biosynthesis
Jeffrey B. Bonanno, Carme Edo, Narayanan Eswar, Ursula Pieper, Michael J. Romanowski, Valentin Ilyin, Sue Ellen Gerchman, Helen Kycia, F. William Studier, Andrej Sali, and Stephen K. Burley
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12896–12901. doi: 10.1073/pnas.181466998.
PMCID: PMC60796
COMPASS: A complex of proteins associated with a trithorax-related SET domain protein
Trissa Miller, Nevan J. Krogan, Jim Dover, H. Erdjument-Bromage, Paul Tempst, Mark Johnston, Jack F. Greenblatt, and Ali Shilatifard
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12902–12907. Published online 2001 October 30. doi: 10.1073/pnas.231473398.
PMCID: PMC60797
Activation of the Akt-related cytokine-independent survival kinase requires interaction of its phox domain with endosomal phosphatidylinositol 3-phosphate
Joseph V. Virbasius, Xi Song, Darcy P. Pomerleau, Yong Zhan, G. Wayne Zhou, and Michael P. Czech
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12908–12913. Published online 2001 October 23. doi: 10.1073/pnas.221352898.
PMCID: PMC60798
Position within the host intron is critical for efficient processing of box C/D snoRNAs in mammalian cells
Tetsuro Hirose and Joan A. Steitz
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12914–12919. Published online 2001 October 23. doi: 10.1073/pnas.231490998.
PMCID: PMC60799
Methionine sulfoxide reductase (MsrA) is a regulator of antioxidant defense and lifespan in mammals
Jackob Moskovitz, Shoshana Bar-Noy, Wesley M. Williams, Jesus Requena, Barbara S. Berlett, and Earl R. Stadtman
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12920–12925. Published online 2001 October 23. doi: 10.1073/pnas.231472998.
PMCID: PMC60800
Intermediates in V(D)J recombination: A stable RAG1/2 complex sequesters cleaved RSS ends
Jessica M. Jones and Martin Gellert
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12926–12931. Published online 2001 October 23. doi: 10.1073/pnas.221471198.
PMCID: PMC60801
From the Cover:
Crystal structure of the precursor of galactose oxidase: An unusual self-processing enzyme
S. J. Firbank, M. S. Rogers, C. M. Wilmot, D. M. Dooley, M. A. Halcrow, P. F. Knowles, M. J. McPherson, and S. E. V. Phillips
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12932–12937. doi: 10.1073/pnas.231463798.
PMCID: PMC60802
YC-1 activation of human soluble guanylyl cyclase has both heme-dependent and heme-independent components
Emil Martin, Yu-Chen Lee, and Ferid Murad
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12938–12942. Published online 2001 October 30. doi: 10.1073/pnas.231486198.
PMCID: PMC60803
Metal ion cooperativity in ribozyme cleavage of RNA
Mathias Brännvall and Leif A. Kirsebom
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12943–12947. Published online 2001 October 23. doi: 10.1073/pnas.221456598.
PMCID: PMC60804
The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics
Stephen B. Long, Paula J. Hancock, Astrid M. Kral, Homme W. Hellinga, and Lorena S. Beese
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12948–12953. Published online 2001 October 30. doi: 10.1073/pnas.241407898.
PMCID: PMC60805
T7 phage display: A novel genetic selection system for cloning RNA-binding proteins from cDNA libraries
Stefan Danner and Joel G. Belasco
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12954–12959. Published online 2001 October 23. doi: 10.1073/pnas.211439598.
PMCID: PMC60806
Cell-type specificity of short-range transcriptional repressors
Jae-Ryeon Ryu, L. Karl Olson, and David N. Arnosti
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12960–12965. Published online 2001 October 30. doi: 10.1073/pnas.231394998.
PMCID: PMC60807
HIV-1 protease cleaves eukaryotic initiation factor 4G and inhibits cap-dependent translation
Iván Ventoso, Raquel Blanco, Celia Perales, and Luis Carrasco
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12966–12971. Published online 2001 October 23. doi: 10.1073/pnas.231343498.
PMCID: PMC60808
Internal initiation in Saccharomyces cerevisiae mediated by an initiator tRNA/eIF2-independent internal ribosome entry site element
Sunnie R. Thompson, Keith D. Gulyas, and Peter Sarnow
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12972–12977. Published online 2001 October 30. doi: 10.1073/pnas.241286698.
PMCID: PMC60809
A PP2C-type phosphatase dephosphorylates the PII signaling protein in the cyanobacterium Synechocystis PCC 6803
Angelika Irmler and Karl Forchhammer
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12978–12983. Published online 2001 October 30. doi: 10.1073/pnas.231254998.
PMCID: PMC60810
Enzyme interactions in heparan sulfate biosynthesis: Uronosyl 5-epimerase and 2-O-sulfotransferase interact in vivo
Maria A. S. Pinhal, Brian Smith, Sara Olson, Jun-ichi Aikawa, Koji Kimata, and Jeffrey D. Esko
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12984–12989. Published online 2001 October 30. doi: 10.1073/pnas.241175798.
PMCID: PMC60811
Engineering a nicking endonuclease N.AlwI by domain swapping
Yan Xu, Keith D. Lunnen, and Huimin Kong
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12990–12995. Published online 2001 October 30. doi: 10.1073/pnas.241215698.
PMCID: PMC60812
Biophysics
Kinetics of duplex formation for individual DNA strands within a single protein nanopore
Stefan Howorka, Liviu Movileanu, Orit Braha, and Hagan Bayley
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12996–13001. Published online 2001 October 23. doi: 10.1073/pnas.231434698.
PMCID: PMC60813
Ultrafast folding of WW domains without structured aromatic clusters in the denatured state
Neil Ferguson, Christopher M. Johnson, Maria Macias, Hartmut Oschkinat, and Alan Fersht
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13002–13007. Published online 2001 October 30. doi: 10.1073/pnas.221467198.
PMCID: PMC60814
Using flexible loop mimetics to extend Φ-value analysis to secondary structure interactions
Neil Ferguson, José Ricardo Pires, Florian Toepert, Christopher M. Johnson, Yong Ping Pan, Rudolf Volkmer-Engert, Jens Schneider-Mergener, Valerie Daggett, Hartmut Oschkinat, and Alan Fersht
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13008–13013. Published online 2001 October 30. doi: 10.1073/pnas.221467398.
PMCID: PMC60815
Constructing, verifying, and dissecting the folding transition state of chymotrypsin inhibitor 2 with all-atom simulations
Lewyn Li and Eugene I. Shakhnovich
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13014–13018. Published online 2001 October 23. doi: 10.1073/pnas.241378398.
PMCID: PMC60816
Support for the multigenic hypothesis of amyloidosis: The binding stoichiometry of retinol-binding protein, vitamin A, and thyroid hormone influences transthyretin amyloidogenicity in vitro
Joleen T. White and Jeffery W. Kelly
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13019–13024. Published online 2001 October 30. doi: 10.1073/pnas.241406698.
PMCID: PMC60817
The NMR structure of the 47-kDa dimeric enzyme 3,4-dihydroxy-2-butanone-4-phosphate synthase and ligand binding studies reveal the location of the active site
Mark J. S. Kelly, Linda J. Ball, Cornelia Krieger, Yihua Yu, Markus Fischer, Susanne Schiffmann, Peter Schmieder, Ronald Kühne, Wolfgang Bermel, Adelbert Bacher, Gerald Richter, and Hartmut Oschkinat
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13025–13030. Published online 2001 October 30. doi: 10.1073/pnas.231323598.
PMCID: PMC60818
Cell Biology
Differentially expressed late constituents of the epidermal cornified envelope
D. Marshall, M. J. Hardman, K. M. Nield, and C. Byrne
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13031–13036. doi: 10.1073/pnas.231489198.
PMCID: PMC60819
From the Cover:
Identification of sites for exponential translation in living dendrites
Christy Job and James Eberwine
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13037–13042. Published online 2001 October 23. doi: 10.1073/pnas.231485698.
PMCID: PMC60820
Design of a retroviral-mediated ecdysone-inducible system and its application to the expression profiling of the PTEN tumor suppressor
Javor Stolarov, Kenneth Chang, Andrew Reiner, Linda Rodgers, Gregory J. Hannon, Michael H. Wigler, and Vivek Mittal
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13043–13048. Published online 2001 October 30. doi: 10.1073/pnas.221450598.
PMCID: PMC60821
A uniform extracellular stimulus triggers distinct cAMP signals in different compartments of a simple cell
Thomas C. Rich, Kent A. Fagan, Tonia E. Tse, Jerome Schaack, Dermot M. F. Cooper, and Jeffrey W. Karpen
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13049–13054. Published online 2001 October 16. doi: 10.1073/pnas.221381398.
PMCID: PMC60822
Reactivation of proliferin gene expression is associated with increased angiogenesis in a cell culture model of fibrosarcoma tumor progression
Daniel J. Toft, Suzanne B. Rosenberg, Gabriele Bergers, Olga Volpert, and Daniel I. H. Linzer
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13055–13059. Published online 2001 October 23. doi: 10.1073/pnas.231364798.
PMCID: PMC60823
Specificity in intracellular protein aggregation and inclusion body formation
Rahul S. Rajan, Michelle E. Illing, Neil F. Bence, and Ron R. Kopito
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13060–13065. Published online 2001 October 30. doi: 10.1073/pnas.181479798.
PMCID: PMC60824
Identification of multiple CDH1 homologues in vertebrates conferring different substrate specificities
Yong Wan and Marc W. Kirschner
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13066–13071. Published online 2001 October 30. doi: 10.1073/pnas.231487598.
PMCID: PMC60825
Cholesterol depletion induces large scale domain segregation in living cell membranes
Mingming Hao, Sushmita Mukherjee, and Frederick R. Maxfield
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13072–13077. doi: 10.1073/pnas.231377398.
PMCID: PMC60826
The coactivator dTAFII110/hTAFII135 is sufficient to recruit a polymerase complex and activate basal transcription mediated by CREB
Edward A. Felinski and Patrick G. Quinn
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13078–13083. Published online 2001 October 30. doi: 10.1073/pnas.241337698.
PMCID: PMC60827
Insulin can regulate GLUT4 internalization by signaling to Rab5 and the motor protein dynein
Jie Huang, Takeshi Imamura, and Jerrold M. Olefsky
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13084–13089. Published online 2001 October 30. doi: 10.1073/pnas.241368698.
PMCID: PMC60828
From the Cover:
Transgenic mice produced by retroviral transduction of male germ-line stem cells
Makoto Nagano, Clayton J. Brinster, Kyle E. Orwig, Buom-Yong Ryu, Mary R. Avarbock, and Ralph L. Brinster
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13090–13095. Published online 2001 October 23. doi: 10.1073/pnas.231473498.
PMCID: PMC60829
Gene expression profiles of light-induced apoptosis in arrestin/rhodopsin kinase-deficient mouse retinas
Sangdun Choi, Wenshan Hao, Ching-Kang Chen, and Melvin I. Simon
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13096–13101. Published online 2001 October 30. doi: 10.1073/pnas.201417498.
PMCID: PMC60830
Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G1/S checkpoint activation in response to DNA damage
Sean Post, Yi-Chinn Weng, Karlene Cimprich, Lan Bo Chen, Yang Xu, and Eva Y.-H. P. Lee
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13102–13107. Published online 2001 October 30. doi: 10.1073/pnas.231364598.
PMCID: PMC60831
Calcineurin controls nerve activity-dependent specification of slow skeletal muscle fibers but not muscle growth
Antonio L. Serrano, Marta Murgia, Giorgia Pallafacchina, Elisa Calabria, Patrizia Coniglio, Terje Lømo, and Stefano Schiaffino
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13108–13113. Published online 2001 October 23. doi: 10.1073/pnas.231148598.
PMCID: PMC60832
Redundant control of rereplication in fission yeast
Vidya Gopalakrishnan, Pamela Simancek, Christopher Houchens, Hilary A. Snaith, Mark G. Frattini, Shelley Sazer, and Thomas J. Kelly
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13114–13119. Published online 2001 October 23. doi: 10.1073/pnas.221467598.
PMCID: PMC60833
Developmental Biology
Meis1a suppresses differentiation by G-CSF and promotes proliferation by SCF: Potential mechanisms of cooperativity with Hoxa9 in myeloid leukemia
Katherine R. Calvo, Paul S. Knoepfler, David B. Sykes, Martina P. Pasillas, and Mark P. Kamps
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13120–13125. Published online 2001 October 30. doi: 10.1073/pnas.231115398.
PMCID: PMC60834
UniGene cDNA array-based monitoring of transcriptome changes during mouse placental development
Myriam Hemberger, James C. Cross, Hans-Hilger Ropers, Hans Lehrach, Reinald Fundele, and Heinz Himmelbauer
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13126–13131. doi: 10.1073/pnas.231396598.
PMCID: PMC60835
A RHO GTPase-mediated pathway is required during P cell migration in Caenorhabditis elegans
Andrew G. Spencer, Satoshi Orita, Christian J. Malone, and Min Han
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13132–13137. Published online 2001 October 30. doi: 10.1073/pnas.241504098.
PMCID: PMC60836
Expression of cyclins E1 and E2 during mouse development and in neoplasia
Yan Geng, Qunyan Yu, Wendy Whoriskey, Fred Dick, Kenneth Y. Tsai, Heide L. Ford, Debajit K. Biswas, Arthur B. Pardee, Bruno Amati, Tyler Jacks, Andrea Richardson, Nicholas Dyson, and Piotr Sicinski
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13138–13143. Published online 2001 October 30. doi: 10.1073/pnas.231487798.
PMCID: PMC60837
Ecology
An unusual vitamin E constituent (α-tocomonoenol) provides enhanced antioxidant protection in marine organisms adapted to cold-water environments
Yorihiro Yamamoto, Akio Fujisawa, Akihiko Hara, and Walter C. Dunlap
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13144–13148. Published online 2001 October 30. doi: 10.1073/pnas.241024298.
PMCID: PMC60838
Phase coupling and synchrony in the spatiotemporal dynamics of muskrat and mink populations across Canada
D. T. Haydon, N. C. Stenseth, M. S. Boyce, and P. E. Greenwood
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13149–13154. Published online 2001 October 23. doi: 10.1073/pnas.221275198.
PMCID: PMC60839
Evolution
Male mate choice selects for female coloration in a fish
Trond Amundsen and Elisabet Forsgren
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13155–13160. Published online 2001 October 16. doi: 10.1073/pnas.211439298.
PMCID: PMC60840
Vestigial preference functions in neural networks and túngara frogs.
S. M. Phelps, M. J. Ryan, and A. S. Rand
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13161–13166. doi: 10.1073/pnas.231296998.
PMCID: PMC60841
From the Cover:
Evolutionary relationships among self-incompatibility RNases
Boris Igic and Joshua R. Kohn
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13167–13171. doi: 10.1073/pnas.231386798.
PMCID: PMC60842
Simulating pseudogene evolution in vitro: Determining the true number of mutations in a lineage
Jean-Pierre Vartanian, Michel Henry, and Simon Wain-Hobson
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13172–13176. Published online 2001 October 30. doi: 10.1073/pnas.221334898.
PMCID: PMC60843
Intron distribution difference for 276 ancient and 131 modern genes suggests the existence of ancient introns
Alexei Fedorov, Xiaohong Cao, Serge Saxonov, Sandro J. de Souza, Scott W. Roy, and Walter Gilbert
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13177–13182. Published online 2001 October 30. doi: 10.1073/pnas.231491498.
PMCID: PMC60844
Sex-ratio segregation distortion associated with reproductive isolation in Drosophila
Yun Tao, Daniel L. Hartl, and Cathy C. Laurie
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13183–13188. Published online 2001 October 30. doi: 10.1073/pnas.231478798.
PMCID: PMC60845
Cost and conflict in animal signals and human language
Michael Lachmann, Szabolcs Számadó, and Carl T. Bergstrom
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13189–13194. Published online 2001 October 30. doi: 10.1073/pnas.231216498.
PMCID: PMC60846
Genetic evidence for adaptation-driven incipient speciation of Drosophila melanogaster along a microclimatic contrast in “Evolution Canyon,” Israel
Pawel Michalak, Irina Minkov, Amanda Helin, Daniel N. Lerman, Brian R. Bettencourt, Martin E. Feder, Abraham B. Korol, and Eviatar Nevo
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13195–13200. Published online 2001 October 30. doi: 10.1073/pnas.231478298.
PMCID: PMC60847
Genetics
Altered transcription in yeast expressing expanded polyglutamine
Robert E. Hughes, Russell S. Lo, Colleen Davis, Andrew D. Strand, Cassandra L. Neal, James M. Olson, and Stanley Fields
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13201–13206. Published online 2001 October 30. doi: 10.1073/pnas.191498198.
PMCID: PMC60848
Retrotransposition of a yeast group II intron occurs by reverse splicing directly into ectopic DNA sites
Lorna Dickson, Hon-Ren Huang, Lu Liu, Manabu Matsuura, Alan M. Lambowitz, and Philip S. Perlman
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13207–13212. Published online 2001 October 30. doi: 10.1073/pnas.231494498.
PMCID: PMC60849
A novel Rtg2p activity regulates nitrogen catabolism in yeast
Michael M. Pierce, Marie-Lise Maddelein, B. Tibor Roberts, and Reed B. Wickner
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13213–13218. Published online 2001 October 30. doi: 10.1073/pnas.181486098.
PMCID: PMC60850
Genetic variation in aldosterone synthase predicts plasma glucose levels
Koustubh Ranade, Kwan Dun Wu, Neil Risch, Michael Olivier, Dee Pei, Chin-Fu Hsiao, Lee-Ming Chuang, Low-Tone Ho, Eric Jorgenson, Robert Pesich, Yii-Der I. Chen, Victor Dzau, Alfred Lin, Richard A. Olshen, David Curb, David R. Cox, and David Botstein
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13219–13224. Published online 2001 October 30. doi: 10.1073/pnas.221467098.
PMCID: PMC60851
Identification of five new genes on the Y chromosome of Drosophila melanogaster
Antonio Bernardo Carvalho, Bridget A. Dobo, Maria D. Vibranovski, and Andrew G. Clark
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13225–13230. Published online 2001 October 30. doi: 10.1073/pnas.231484998.
PMCID: PMC60852
Genetic characterization of the body attributed to the evangelist Luke
Cristiano Vernesi, Giulietta Di Benedetto, David Caramelli, Erica Secchieri, Lucia Simoni, Emile Katti, Patrizia Malaspina, Andrea Novelletto, Vito Terribile Wiel Marin, and Guido Barbujani
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13460–13463. Published online 2001 October 16. doi: 10.1073/pnas.211540498.
PMCID: PMC60893
Immunology
Structure of the interferon-receptor complex determined by distance constraints from double-mutant cycles and flexible docking
Laila C. Roisman, Jacob Piehler, Jean-Yves Trosset, Harold A. Scheraga, and Gideon Schreiber
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13231–13236. doi: 10.1073/pnas.221290398.
PMCID: PMC60853
The infiltration kinetics of simian immunodeficiency virus-specific T cells drawn to sites of high antigenic stimulation determines local in vivo viral escape
Philippe Blancou, Nicole Chenciner, Marie-Christine Cumont, Simon Wain-Hobson, Bruno Hurtrel, and Rémi Cheynier
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13237–13242. Published online 2001 October 30. doi: 10.1073/pnas.231348598.
PMCID: PMC60854
Th1-polarizing immunization with egg antigens correlates with severe exacerbation of immunopathology and death in schistosome infection
Laura I. Rutitzky, Hector J. Hernandez, and Miguel J. Stadecker
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13243–13248. Published online 2001 October 23. doi: 10.1073/pnas.231258498.
PMCID: PMC60855
IL-1β-converting enzyme (caspase-1) in intestinal inflammation
Britta Siegmund, Hans-Anton Lehr, Giamila Fantuzzi, and Charles A. Dinarello
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13249–13254. Published online 2001 October 23. doi: 10.1073/pnas.231473998.
PMCID: PMC60856
Frameshift-mutation-derived peptides as tumor-specific antigens in inherited and spontaneous colorectal cancer
Ingvil Sæterdal, Jens Bjørheim, Kari Lislerud, Marianne K. Gjertsen, Ida K. Bukholm, Ole Christian Olsen, Jahn M. Nesland, Jon Amund Eriksen, Mona Møller, Annika Lindblom, and Gustav Gaudernack
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13255–13260. Published online 2001 October 30. doi: 10.1073/pnas.231326898.
PMCID: PMC60857
Medical Sciences
The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo
Jian-Guo Zhang, Donald Metcalf, Steven Rakar, Maria Asimakis, Christopher J. Greenhalgh, Tracy A. Willson, Robyn Starr, Sandra E. Nicholson, Wendy Carter, Warren S. Alexander, Douglas J. Hilton, and Nicos A. Nicola
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13261–13265. Published online 2001 October 23. doi: 10.1073/pnas.231486498.
PMCID: PMC60858
Project normal: Defining normal variance in mouse gene expression
Colin C. Pritchard, Li Hsu, Jeffrey Delrow, and Peter S. Nelson
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13266–13271. doi: 10.1073/pnas.221465998.
PMCID: PMC60859
Personality traits and brain dopaminergic function in Parkinson's disease
Valtteri Kaasinen, Elina Nurmi, Jörgen Bergman, Olli Eskola, Olof Solin, Pirkko Sonninen, and Juha O. Rinne
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13272–13277. Published online 2001 October 30. doi: 10.1073/pnas.231313198.
PMCID: PMC60860
Targeting Plasmodium ligands on mosquito salivary glands and midgut with a phage display peptide library
Anil K. Ghosh, Paulo E. M. Ribolla, and Marcelo Jacobs-Lorena
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13278–13281. Published online 2001 October 30. doi: 10.1073/pnas.241491198.
PMCID: PMC60861
Lifetime correction of genetic deficiency in mice with a single injection of helper-dependent adenoviral vector
In-Hoo Kim, Alicja Józkowicz, Pedro A. Piedra, Kazuhiro Oka, and Lawrence Chan
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13282–13287. Published online 2001 October 30. doi: 10.1073/pnas.241506298.
PMCID: PMC60862
Structured antiretroviral treatment interruptions in chronically HIV-1-infected subjects
Gabriel M. Ortiz, Melissa Wellons, Jason Brancato, Ha T. T. Vo, Rebekah L. Zinn, Daniel E. Clarkson, Katherine Van Loon, Sebastian Bonhoeffer, G. Diego Miralles, David Montefiori, John A. Bartlett, and Douglas F. Nixon
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13288–13293. Published online 2001 October 30. doi: 10.1073/pnas.221452198.
PMCID: PMC60863
Compared with saturated fatty acids, dietary monounsaturated fatty acids and carbohydrates increase atherosclerosis and VLDL cholesterol levels in LDL receptor-deficient, but not apolipoprotein E-deficient, mice
Martin Merkel, Wanda Velez-Carrasco, Lisa C. Hudgins, and Jan L. Breslow
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13294–13299. Published online 2001 October 23. doi: 10.1073/pnas.231490498.
PMCID: PMC60864
Delayed replication timing leads to delayed mitotic chromosome condensation and chromosomal instability of chromosome translocations
Leslie Smith, Annemieke Plug, and Mathew Thayer
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13300–13305. doi: 10.1073/pnas.241355098.
PMCID: PMC60865
Enterocolitis induced by autoimmune targeting of enteric glial cells: A possible mechanism in Crohn's disease?
Anne Cornet, Tor C. Savidge, Julie Cabarrocas, Wen-Lin Deng, Jean-Frederic Colombel, Hans Lassmann, Pierre Desreumaux, and Roland S. Liblau
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13306–13311. Published online 2001 October 30. doi: 10.1073/pnas.231474098.
PMCID: PMC60866
Invasive melanoma in Cdk4-targeted mice
Rocío Sotillo, Juan F. García, Sagrario Ortega, Javier Martín, Pierre Dubus, Mariano Barbacid, and Marcos Malumbres
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13312–13317. Published online 2001 October 23. doi: 10.1073/pnas.241338598.
PMCID: PMC60867
Expanded polyglutamines in Caenorhabditis elegans cause axonal abnormalities and severe dysfunction of PLM mechanosensory neurons without cell death
J. Alex Parker, John B. Connolly, Cheryll Wellington, Michael Hayden, Jean Dausset, and Christian Neri
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13318–13323. Published online 2001 October 30. doi: 10.1073/pnas.231476398.
PMCID: PMC60868
Duodenal calcium absorption in vitamin D receptor–knockout mice: Functional and molecular aspects
Sophie J. Van Cromphaut, Mieke Dewerchin, Joost G. J. Hoenderop, Ingrid Stockmans, Erik Van Herck, Shigeaki Kato, René J. M. Bindels, Désiré Collen, Peter Carmeliet, Roger Bouillon, and Geert Carmeliet
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13324–13329. Published online 2001 October 30. doi: 10.1073/pnas.231474698.
PMCID: PMC60869
Genetically increased angiotensin I-converting enzyme level and renal complications in the diabetic mouse
Wei Huang, Yves Gallois, Nadine Bouby, Patrick Bruneval, Didier Heudes, Marie-France Belair, John H. Krege, Pierre Meneton, Michel Marre, Oliver Smithies, and François Alhenc-Gelas
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13330–13334. Published online 2001 October 30. doi: 10.1073/pnas.231476798.
PMCID: PMC60870
Microbiology
Use of a dynamic in vitro attachment and invasion system (DIVAS) to determine influence of growth rate on invasion of respiratory epithelial cells by group B Streptococcus
Gennady Malin and Lawrence C. Paoletti
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13335–13340. Published online 2001 October 30. doi: 10.1073/pnas.241079098.
PMCID: PMC60871
Viruses from extreme thermal environments
George Rice, Kenneth Stedman, Jamie Snyder, Blake Wiedenheft, Debbie Willits, Susan Brumfield, Timothy McDermott, and Mark J. Young
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13341–13345. Published online 2001 October 23. doi: 10.1073/pnas.231170198.
PMCID: PMC60872
Nitrogen cycling by wood decomposing soft-rot fungi in the “King Midas tomb,” Gordion, Turkey
Timothy R. Filley, Robert A. Blanchette, Elizabeth Simpson, and Marilyn L. Fogel
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13346–13350. Published online 2001 October 23. doi: 10.1073/pnas.221299598.
PMCID: PMC60873
Neurobiology
Increased sensitivity to cocaine by cholinergic cell ablation in nucleus accumbens
Takatoshi Hikida, Satoshi Kaneko, Tomohiro Isobe, Yasuji Kitabatake, Dai Watanabe, Ira Pastan, and Shigetada Nakanishi
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13351–13354. Published online 2001 October 23. doi: 10.1073/pnas.231488998.
PMCID: PMC60874
Altered psychomotor behaviors in mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP)
Hitoshi Hashimoto, Norihito Shintani, Kazuhiro Tanaka, Wakaba Mori, Megumi Hirose, Toshio Matsuda, Masaki Sakaue, Jun-ichi Miyazaki, Hitoshi Niwa, Fumi Tashiro, Kyohei Yamamoto, Kazumi Koga, Shuhei Tomimoto, Akiyoshi Kunugi, Sayoko Suetake, and Akemichi Baba
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13355–13360. Published online 2001 October 30. doi: 10.1073/pnas.231094498.
PMCID: PMC60875
Chromosomal variation in neurons of the developing and adult mammalian nervous system
Stevens Kastrup Rehen, Michael J. McConnell, Dhruv Kaushal, Marcy A. Kingsbury, Amy H. Yang, and Jerold Chun
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13361–13366. doi: 10.1073/pnas.231487398.
PMCID: PMC60876
Speech comprehension is correlated with temporal response patterns recorded from auditory cortex
Ehud Ahissar, Srikantan Nagarajan, Merav Ahissar, Athanassios Protopapas, Henry Mahncke, and Michael M. Merzenich
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13367–13372. doi: 10.1073/pnas.201400998.
PMCID: PMC60877
Distinct potassium channels on pain-sensing neurons
Matthew N. Rasband, Eunice W. Park, Todd W. Vanderah, Josephine Lai, Frank Porreca, and James S. Trimmer
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13373–13378. doi: 10.1073/pnas.231376298.
PMCID: PMC60878
Early postnatal ataxia and abnormal cerebellar development in mice lacking Xeroderma pigmentosum Group A and Cockayne Syndrome Group B DNA repair genes
Machiko Murai, Yasushi Enokido, Naoko Inamura, Masafumi Yoshino, Yoshimichi Nakatsu, Gijsbertus T. J. van der Horst, Jan H. J. Hoeijmakers, Kiyoji Tanaka, and Hiroshi Hatanaka
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13379–13384. Published online 2001 October 30. doi: 10.1073/pnas.231329598.
PMCID: PMC60879
c-Jun mediates axotomy-induced dopamine neuron death in vivo
S. J. Crocker, W. R. Lamba, P. D. Smith, S. M. Callaghan, R. S. Slack, H. Anisman, and D. S. Park
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13385–13390. Published online 2001 October 30. doi: 10.1073/pnas.231177098.
PMCID: PMC60880
Cyclic changes in estradiol regulate synaptic plasticity through the MAP kinase pathway
Ruifen Bi, Michael R. Foy, Rose-Marie Vouimba, Richard F. Thompson, and Michel Baudry
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13391–13395. Published online 2001 October 30. doi: 10.1073/pnas.241507698.
PMCID: PMC60881
Vanilloid receptor expression suggests a sensory role for urinary bladder epithelial cells
Lori A. Birder, Anthony J. Kanai, William C. de Groat, Susanna Kiss, Michele L. Nealen, Nancy E. Burke, Kirk E. Dineley, Simon Watkins, Ian J. Reynolds, and Michael J. Caterina
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13396–13401. Published online 2001 October 23. doi: 10.1073/pnas.231243698.
PMCID: PMC60882
Pharmacology
Positive allosteric modulators of metabotropic glutamate 1 receptor: Characterization, mechanism of action, and binding site
Frédéric Knoflach, Vincent Mutel, Synèse Jolidon, James N. C. Kew, Pari Malherbe, Eric Vieira, Jürgen Wichmann, and John A. Kemp
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13402–13407. Published online 2001 October 23. doi: 10.1073/pnas.231358298.
PMCID: PMC60883
Physiology
A paradox resolved: Sulfide acquisition by roots of seep tubeworms sustains net chemoautotrophy
John K. Freytag, Peter R. Girguis, Derk C. Bergquist, Jason P. Andras, James J. Childress, and Charles R. Fisher
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13408–13413. Published online 2001 October 30. doi: 10.1073/pnas.231589498.
PMCID: PMC60884
The expression of the γ subunit of Na-K-ATPase is regulated by osmolality via C-terminal Jun kinase and phosphatidylinositol 3-kinase-dependent mechanisms
J. M. Capasso, C. Rivard, and T. Berl
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13414–13419. Published online 2001 October 30. doi: 10.1073/pnas.231309198.
PMCID: PMC60885
Ouabain, a steroid hormone that signals with slow calcium oscillations
Oleg Aizman, Per Uhlén, Mark Lal, Hjalmar Brismar, and Anita Aperia
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13420–13424. Published online 2001 October 30. doi: 10.1073/pnas.221315298.
PMCID: PMC60886
Plant Biology
Structural requirements of endopolygalacturonase for the interaction with PGIP (polygalacturonase-inhibiting protein)
L. Federici, C. Caprari, B. Mattei, C. Savino, A. Di Matteo, G. De Lorenzo, F. Cervone, and D. Tsernoglou
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13425–13430. Published online 2001 October 30. doi: 10.1073/pnas.231473698.
PMCID: PMC60887
A new class of oxidosqualene cyclases directs synthesis of antimicrobial phytoprotectants in monocots
K. Haralampidis, G. Bryan, X. Qi, K. Papadopoulou, S. Bakht, R. Melton, and A. Osbourn
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13431–13436. Published online 2001 October 23. doi: 10.1073/pnas.231324698.
PMCID: PMC60888
RNAi-mediated oncogene silencing confers resistance to crown gall tumorigenesis
Matthew A. Escobar, Edwin L. Civerolo, Kristin R. Summerfelt, and Abhaya M. Dandekar
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13437–13442. Published online 2001 October 30. doi: 10.1073/pnas.241276898.
PMCID: PMC60889
The initial steps of biogenesis of cyanobacterial photosystems occur in plasma membranes
Elena Zak, Birgitta Norling, Radhashree Maitra, Fang Huang, Bertil Andersson, and Himadri B. Pakrasi
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13443–13448. Published online 2001 October 30. doi: 10.1073/pnas.241503898.
PMCID: PMC60890
The plant oncogene rolD encodes a functional ornithine cyclodeaminase
Maurizio Trovato, Bruno Maras, Francisco Linhares, and Paolo Costantino
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13449–13453. Published online 2001 October 30. doi: 10.1073/pnas.231320398.
PMCID: PMC60891
Signal interactions between nitric oxide and reactive oxygen intermediates in the plant hypersensitive disease resistance response
Massimo Delledonne, Jürgen Zeier, Adriano Marocco, and Chris Lamb
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13454–13459. Published online 2001 October 23. doi: 10.1073/pnas.231178298.
PMCID: PMC60892
Social Sciences
Anthropology
Paternity and relatedness in wild chimpanzee communities
Linda Vigilant, Michael Hofreiter, Heike Siedel, and Christophe Boesch
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12890–12895. Published online 2001 October 23. doi: 10.1073/pnas.231320498.
PMCID: PMC60795
Nitrogen cycling by wood decomposing soft-rot fungi in the “King Midas tomb,” Gordion, Turkey
Timothy R. Filley, Robert A. Blanchette, Elizabeth Simpson, and Marilyn L. Fogel
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13346–13350. Published online 2001 October 23. doi: 10.1073/pnas.221299598.
PMCID: PMC60873
Genetic characterization of the body attributed to the evangelist Luke
Cristiano Vernesi, Giulietta Di Benedetto, David Caramelli, Erica Secchieri, Lucia Simoni, Emile Katti, Patrizia Malaspina, Andrea Novelletto, Vito Terribile Wiel Marin, and Guido Barbujani
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13460–13463. Published online 2001 October 16. doi: 10.1073/pnas.211540498.
PMCID: PMC60893
Psychology
Spoken word production: A theory of lexical access
Willem J. M. Levelt
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13464–13471. doi: 10.1073/pnas.231459498.
PMCID: PMC60894
Corrections
Correction
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13472.
PMCID: PMC60895
Corrects: Qing-Xin Hua, et al. Diabetes-associated mutations in a β-cell transcription factor destabilize an antiparallel “mini-zipper” in a dimerization interface. Proc Natl Acad Sci U S A. 2000 February 29; 97(5): 1999–2004.
Correction
Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13472.
PMCID: PMC60896
Corrects: Emma E. Hamilton-Williams, et al. Transgenic rescue implicates β2-microglobulin as a diabetes susceptibility gene in nonobese diabetic (NOD) mice. Proc Natl Acad Sci U S A. 2001 September 25; 98(20): 11533–11538.
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