| | This journal provides immediate access to some articles. From the Academy U.S. Frontiers Of Science Symposium Introduction to Frontiers of Science Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12869. Published online 2001 October 30. doi: 10.1073/pnas.241391198.PMCID: PMC60787 Surface molecular recognition Nicole S. Sampson, Milan Mrksich, and Carolyn R. Bertozzi Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12870–12871. Published online 2001 October 30. doi: 10.1073/pnas.231391398.PMCID: PMC60788 Mathematical frontiers in optical solitons Jared C. Bronski, Mordechai Segev, and Michael I. Weinstein Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12872–12873. Published online 2001 October 30. doi: 10.1073/pnas.231499298.PMCID: PMC60789 The acquisition of language by children Jenny R. Saffran, Ann Senghas, and John C. Trueswell Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12874–12875. Published online 2001 October 30. doi: 10.1073/pnas.231498898.PMCID: PMC60790 The North Atlantic Oscillation: Past, present, and future Martin H. Visbeck, James W. Hurrell, Lorenzo Polvani, and Heidi M. Cullen Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12876–12877. Published online 2001 October 30. doi: 10.1073/pnas.231391598.PMCID: PMC60791 Commentaries Peptide signaling in plants Henk J. Franssen and Ton Bisseling Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12855–12856. doi: 10.1073/pnas.231490798.PMCID: PMC60782 Sex roles, ornaments, and evolutionary explanation Anne E. Houde Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12857–12859. doi: 10.1073/pnas.241503598.PMCID: PMC60783 DNA repair on the brain R. R. Laposa and J. E. Cleaver Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12860–12862. doi: 10.1073/pnas.241519498.PMCID: PMC60784 Homemade cofactors: Self-processing in galactose oxidase Lili Xie and Wilfred A. van der Donk Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12863–12865. doi: 10.1073/pnas.231485998.PMCID: PMC60785 Unleashing yeast genetics on a factor-independent mechanism of internal translation initiation Alan G. Hinnebusch Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12866–12868. doi: 10.1073/pnas.241517998.PMCID: PMC60786 Physical Sciences Applied Mathematics Self-similar intermediate asymptotics for nonlinear degenerate parabolic free-boundary problems that occur in image processing G. I. Barenblatt Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12878–12881. Published online 2001 October 23. doi: 10.1073/pnas.241501698.PMCID: PMC60792 Mathematics From the Cover: Congruence properties for the partition function Scott Ahlgren and Ken Ono Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12882–12884. Published online 2001 October 23. doi: 10.1073/pnas.191488598.PMCID: PMC60793 Biological Sciences Agricultural Sciences A phylogenetic approach to following West Nile virus in Connecticut John F. Anderson, Charles R. Vossbrinck, Theodore G. Andreadis, Anthony Iton, William H. Beckwith, III, and Donald R. Mayo Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12885–12889. Published online 2001 October 23. doi: 10.1073/pnas.241472398.PMCID: PMC60794 Anthropology Paternity and relatedness in wild chimpanzee communities Linda Vigilant, Michael Hofreiter, Heike Siedel, and Christophe Boesch Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12890–12895. Published online 2001 October 23. doi: 10.1073/pnas.231320498.PMCID: PMC60795 Biochemistry Structural genomics of enzymes involved in sterol/isoprenoid biosynthesis Jeffrey B. Bonanno, Carme Edo, Narayanan Eswar, Ursula Pieper, Michael J. Romanowski, Valentin Ilyin, Sue Ellen Gerchman, Helen Kycia, F. William Studier, Andrej Sali, and Stephen K. Burley Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12896–12901. doi: 10.1073/pnas.181466998.PMCID: PMC60796 COMPASS: A complex of proteins associated with a trithorax-related SET domain protein Trissa Miller, Nevan J. Krogan, Jim Dover, H. Erdjument-Bromage, Paul Tempst, Mark Johnston, Jack F. Greenblatt, and Ali Shilatifard Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12902–12907. Published online 2001 October 30. doi: 10.1073/pnas.231473398.PMCID: PMC60797 Activation of the Akt-related cytokine-independent survival kinase requires interaction of its phox domain with endosomal phosphatidylinositol 3-phosphate Joseph V. Virbasius, Xi Song, Darcy P. Pomerleau, Yong Zhan, G. Wayne Zhou, and Michael P. Czech Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12908–12913. Published online 2001 October 23. doi: 10.1073/pnas.221352898.PMCID: PMC60798 Position within the host intron is critical for efficient processing of box C/D snoRNAs in mammalian cells Tetsuro Hirose and Joan A. Steitz Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12914–12919. Published online 2001 October 23. doi: 10.1073/pnas.231490998.PMCID: PMC60799 Methionine sulfoxide reductase (MsrA) is a regulator of antioxidant defense and lifespan in mammals Jackob Moskovitz, Shoshana Bar-Noy, Wesley M. Williams, Jesus Requena, Barbara S. Berlett, and Earl R. Stadtman Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12920–12925. Published online 2001 October 23. doi: 10.1073/pnas.231472998.PMCID: PMC60800 Intermediates in V(D)J recombination: A stable RAG1/2 complex sequesters cleaved RSS ends Jessica M. Jones and Martin Gellert Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12926–12931. Published online 2001 October 23. doi: 10.1073/pnas.221471198.PMCID: PMC60801 From the Cover: Crystal structure of the precursor of galactose oxidase: An unusual self-processing enzyme S. J. Firbank, M. S. Rogers, C. M. Wilmot, D. M. Dooley, M. A. Halcrow, P. F. Knowles, M. J. McPherson, and S. E. V. Phillips Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12932–12937. doi: 10.1073/pnas.231463798.PMCID: PMC60802 YC-1 activation of human soluble guanylyl cyclase has both heme-dependent and heme-independent components Emil Martin, Yu-Chen Lee, and Ferid Murad Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12938–12942. Published online 2001 October 30. doi: 10.1073/pnas.231486198.PMCID: PMC60803 Metal ion cooperativity in ribozyme cleavage of RNA Mathias Brännvall and Leif A. Kirsebom Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12943–12947. Published online 2001 October 23. doi: 10.1073/pnas.221456598.PMCID: PMC60804 The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics Stephen B. Long, Paula J. Hancock, Astrid M. Kral, Homme W. Hellinga, and Lorena S. Beese Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12948–12953. Published online 2001 October 30. doi: 10.1073/pnas.241407898.PMCID: PMC60805 T7 phage display: A novel genetic selection system for cloning RNA-binding proteins from cDNA libraries Stefan Danner and Joel G. Belasco Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12954–12959. Published online 2001 October 23. doi: 10.1073/pnas.211439598.PMCID: PMC60806 Cell-type specificity of short-range transcriptional repressors Jae-Ryeon Ryu, L. Karl Olson, and David N. Arnosti Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12960–12965. Published online 2001 October 30. doi: 10.1073/pnas.231394998.PMCID: PMC60807 HIV-1 protease cleaves eukaryotic initiation factor 4G and inhibits cap-dependent translation Iván Ventoso, Raquel Blanco, Celia Perales, and Luis Carrasco Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12966–12971. Published online 2001 October 23. doi: 10.1073/pnas.231343498.PMCID: PMC60808 Internal initiation in Saccharomyces cerevisiae mediated by an initiator tRNA/eIF2-independent internal ribosome entry site element Sunnie R. Thompson, Keith D. Gulyas, and Peter Sarnow Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12972–12977. Published online 2001 October 30. doi: 10.1073/pnas.241286698.PMCID: PMC60809 A PP2C-type phosphatase dephosphorylates the PII signaling protein in the cyanobacterium Synechocystis PCC 6803 Angelika Irmler and Karl Forchhammer Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12978–12983. Published online 2001 October 30. doi: 10.1073/pnas.231254998.PMCID: PMC60810 Enzyme interactions in heparan sulfate biosynthesis: Uronosyl 5-epimerase and 2-O-sulfotransferase interact in vivo Maria A. S. Pinhal, Brian Smith, Sara Olson, Jun-ichi Aikawa, Koji Kimata, and Jeffrey D. Esko Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12984–12989. Published online 2001 October 30. doi: 10.1073/pnas.241175798.PMCID: PMC60811 Engineering a nicking endonuclease N.AlwI by domain swapping Yan Xu, Keith D. Lunnen, and Huimin Kong Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12990–12995. Published online 2001 October 30. doi: 10.1073/pnas.241215698.PMCID: PMC60812 Biophysics Kinetics of duplex formation for individual DNA strands within a single protein nanopore Stefan Howorka, Liviu Movileanu, Orit Braha, and Hagan Bayley Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12996–13001. Published online 2001 October 23. doi: 10.1073/pnas.231434698.PMCID: PMC60813 Ultrafast folding of WW domains without structured aromatic clusters in the denatured state Neil Ferguson, Christopher M. Johnson, Maria Macias, Hartmut Oschkinat, and Alan Fersht Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13002–13007. Published online 2001 October 30. doi: 10.1073/pnas.221467198.PMCID: PMC60814 Using flexible loop mimetics to extend Φ-value analysis to secondary structure interactions Neil Ferguson, José Ricardo Pires, Florian Toepert, Christopher M. Johnson, Yong Ping Pan, Rudolf Volkmer-Engert, Jens Schneider-Mergener, Valerie Daggett, Hartmut Oschkinat, and Alan Fersht Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13008–13013. Published online 2001 October 30. doi: 10.1073/pnas.221467398.PMCID: PMC60815 Constructing, verifying, and dissecting the folding transition state of chymotrypsin inhibitor 2 with all-atom simulations Lewyn Li and Eugene I. Shakhnovich Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13014–13018. Published online 2001 October 23. doi: 10.1073/pnas.241378398.PMCID: PMC60816 Support for the multigenic hypothesis of amyloidosis: The binding stoichiometry of retinol-binding protein, vitamin A, and thyroid hormone influences transthyretin amyloidogenicity in vitro Joleen T. White and Jeffery W. Kelly Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13019–13024. Published online 2001 October 30. doi: 10.1073/pnas.241406698.PMCID: PMC60817 The NMR structure of the 47-kDa dimeric enzyme 3,4-dihydroxy-2-butanone-4-phosphate synthase and ligand binding studies reveal the location of the active site Mark J. S. Kelly, Linda J. Ball, Cornelia Krieger, Yihua Yu, Markus Fischer, Susanne Schiffmann, Peter Schmieder, Ronald Kühne, Wolfgang Bermel, Adelbert Bacher, Gerald Richter, and Hartmut Oschkinat Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13025–13030. Published online 2001 October 30. doi: 10.1073/pnas.231323598.PMCID: PMC60818 Cell Biology Differentially expressed late constituents of the epidermal cornified envelope D. Marshall, M. J. Hardman, K. M. Nield, and C. Byrne Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13031–13036. doi: 10.1073/pnas.231489198.PMCID: PMC60819 From the Cover: Identification of sites for exponential translation in living dendrites Christy Job and James Eberwine Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13037–13042. Published online 2001 October 23. doi: 10.1073/pnas.231485698.PMCID: PMC60820 Design of a retroviral-mediated ecdysone-inducible system and its application to the expression profiling of the PTEN tumor suppressor Javor Stolarov, Kenneth Chang, Andrew Reiner, Linda Rodgers, Gregory J. Hannon, Michael H. Wigler, and Vivek Mittal Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13043–13048. Published online 2001 October 30. doi: 10.1073/pnas.221450598.PMCID: PMC60821 A uniform extracellular stimulus triggers distinct cAMP signals in different compartments of a simple cell Thomas C. Rich, Kent A. Fagan, Tonia E. Tse, Jerome Schaack, Dermot M. F. Cooper, and Jeffrey W. Karpen Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13049–13054. Published online 2001 October 16. doi: 10.1073/pnas.221381398.PMCID: PMC60822 Reactivation of proliferin gene expression is associated with increased angiogenesis in a cell culture model of fibrosarcoma tumor progression Daniel J. Toft, Suzanne B. Rosenberg, Gabriele Bergers, Olga Volpert, and Daniel I. H. Linzer Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13055–13059. Published online 2001 October 23. doi: 10.1073/pnas.231364798.PMCID: PMC60823 Specificity in intracellular protein aggregation and inclusion body formation Rahul S. Rajan, Michelle E. Illing, Neil F. Bence, and Ron R. Kopito Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13060–13065. Published online 2001 October 30. doi: 10.1073/pnas.181479798.PMCID: PMC60824 Identification of multiple CDH1 homologues in vertebrates conferring different substrate specificities Yong Wan and Marc W. Kirschner Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13066–13071. Published online 2001 October 30. doi: 10.1073/pnas.231487598.PMCID: PMC60825 Cholesterol depletion induces large scale domain segregation in living cell membranes Mingming Hao, Sushmita Mukherjee, and Frederick R. Maxfield Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13072–13077. doi: 10.1073/pnas.231377398.PMCID: PMC60826 The coactivator dTAFII110/hTAFII135 is sufficient to recruit a polymerase complex and activate basal transcription mediated by CREB Edward A. Felinski and Patrick G. Quinn Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13078–13083. Published online 2001 October 30. doi: 10.1073/pnas.241337698.PMCID: PMC60827 Insulin can regulate GLUT4 internalization by signaling to Rab5 and the motor protein dynein Jie Huang, Takeshi Imamura, and Jerrold M. Olefsky Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13084–13089. Published online 2001 October 30. doi: 10.1073/pnas.241368698.PMCID: PMC60828 From the Cover: Transgenic mice produced by retroviral transduction of male germ-line stem cells Makoto Nagano, Clayton J. Brinster, Kyle E. Orwig, Buom-Yong Ryu, Mary R. Avarbock, and Ralph L. Brinster Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13090–13095. Published online 2001 October 23. doi: 10.1073/pnas.231473498.PMCID: PMC60829 Gene expression profiles of light-induced apoptosis in arrestin/rhodopsin kinase-deficient mouse retinas Sangdun Choi, Wenshan Hao, Ching-Kang Chen, and Melvin I. Simon Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13096–13101. Published online 2001 October 30. doi: 10.1073/pnas.201417498.PMCID: PMC60830 Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G1/S checkpoint activation in response to DNA damage Sean Post, Yi-Chinn Weng, Karlene Cimprich, Lan Bo Chen, Yang Xu, and Eva Y.-H. P. Lee Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13102–13107. Published online 2001 October 30. doi: 10.1073/pnas.231364598.PMCID: PMC60831 Calcineurin controls nerve activity-dependent specification of slow skeletal muscle fibers but not muscle growth Antonio L. Serrano, Marta Murgia, Giorgia Pallafacchina, Elisa Calabria, Patrizia Coniglio, Terje Lømo, and Stefano Schiaffino Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13108–13113. Published online 2001 October 23. doi: 10.1073/pnas.231148598.PMCID: PMC60832 Redundant control of rereplication in fission yeast Vidya Gopalakrishnan, Pamela Simancek, Christopher Houchens, Hilary A. Snaith, Mark G. Frattini, Shelley Sazer, and Thomas J. Kelly Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13114–13119. Published online 2001 October 23. doi: 10.1073/pnas.221467598.PMCID: PMC60833 Developmental Biology Meis1a suppresses differentiation by G-CSF and promotes proliferation by SCF: Potential mechanisms of cooperativity with Hoxa9 in myeloid leukemia Katherine R. Calvo, Paul S. Knoepfler, David B. Sykes, Martina P. Pasillas, and Mark P. Kamps Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13120–13125. Published online 2001 October 30. doi: 10.1073/pnas.231115398.PMCID: PMC60834 UniGene cDNA array-based monitoring of transcriptome changes during mouse placental development Myriam Hemberger, James C. Cross, Hans-Hilger Ropers, Hans Lehrach, Reinald Fundele, and Heinz Himmelbauer Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13126–13131. doi: 10.1073/pnas.231396598.PMCID: PMC60835 A RHO GTPase-mediated pathway is required during P cell migration in Caenorhabditis elegans Andrew G. Spencer, Satoshi Orita, Christian J. Malone, and Min Han Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13132–13137. Published online 2001 October 30. doi: 10.1073/pnas.241504098.PMCID: PMC60836 Expression of cyclins E1 and E2 during mouse development and in neoplasia Yan Geng, Qunyan Yu, Wendy Whoriskey, Fred Dick, Kenneth Y. Tsai, Heide L. Ford, Debajit K. Biswas, Arthur B. Pardee, Bruno Amati, Tyler Jacks, Andrea Richardson, Nicholas Dyson, and Piotr Sicinski Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13138–13143. Published online 2001 October 30. doi: 10.1073/pnas.231487798.PMCID: PMC60837 Ecology An unusual vitamin E constituent (α-tocomonoenol) provides enhanced antioxidant protection in marine organisms adapted to cold-water environments Yorihiro Yamamoto, Akio Fujisawa, Akihiko Hara, and Walter C. Dunlap Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13144–13148. Published online 2001 October 30. doi: 10.1073/pnas.241024298.PMCID: PMC60838 Phase coupling and synchrony in the spatiotemporal dynamics of muskrat and mink populations across Canada D. T. Haydon, N. C. Stenseth, M. S. Boyce, and P. E. Greenwood Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13149–13154. Published online 2001 October 23. doi: 10.1073/pnas.221275198.PMCID: PMC60839 Evolution Male mate choice selects for female coloration in a fish Trond Amundsen and Elisabet Forsgren Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13155–13160. Published online 2001 October 16. doi: 10.1073/pnas.211439298.PMCID: PMC60840 Vestigial preference functions in neural networks and túngara frogs. S. M. Phelps, M. J. Ryan, and A. S. Rand Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13161–13166. doi: 10.1073/pnas.231296998.PMCID: PMC60841 From the Cover: Evolutionary relationships among self-incompatibility RNases Boris Igic and Joshua R. Kohn Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13167–13171. doi: 10.1073/pnas.231386798.PMCID: PMC60842 Simulating pseudogene evolution in vitro: Determining the true number of mutations in a lineage Jean-Pierre Vartanian, Michel Henry, and Simon Wain-Hobson Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13172–13176. Published online 2001 October 30. doi: 10.1073/pnas.221334898.PMCID: PMC60843 Intron distribution difference for 276 ancient and 131 modern genes suggests the existence of ancient introns Alexei Fedorov, Xiaohong Cao, Serge Saxonov, Sandro J. de Souza, Scott W. Roy, and Walter Gilbert Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13177–13182. Published online 2001 October 30. doi: 10.1073/pnas.231491498.PMCID: PMC60844 Sex-ratio segregation distortion associated with reproductive isolation in Drosophila Yun Tao, Daniel L. Hartl, and Cathy C. Laurie Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13183–13188. Published online 2001 October 30. doi: 10.1073/pnas.231478798.PMCID: PMC60845 Cost and conflict in animal signals and human language Michael Lachmann, Szabolcs Számadó, and Carl T. Bergstrom Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13189–13194. Published online 2001 October 30. doi: 10.1073/pnas.231216498.PMCID: PMC60846 Genetic evidence for adaptation-driven incipient speciation of Drosophila melanogaster along a microclimatic contrast in “Evolution Canyon,” Israel Pawel Michalak, Irina Minkov, Amanda Helin, Daniel N. Lerman, Brian R. Bettencourt, Martin E. Feder, Abraham B. Korol, and Eviatar Nevo Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13195–13200. Published online 2001 October 30. doi: 10.1073/pnas.231478298.PMCID: PMC60847 Genetics Altered transcription in yeast expressing expanded polyglutamine Robert E. Hughes, Russell S. Lo, Colleen Davis, Andrew D. Strand, Cassandra L. Neal, James M. Olson, and Stanley Fields Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13201–13206. Published online 2001 October 30. doi: 10.1073/pnas.191498198.PMCID: PMC60848 Retrotransposition of a yeast group II intron occurs by reverse splicing directly into ectopic DNA sites Lorna Dickson, Hon-Ren Huang, Lu Liu, Manabu Matsuura, Alan M. Lambowitz, and Philip S. Perlman Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13207–13212. Published online 2001 October 30. doi: 10.1073/pnas.231494498.PMCID: PMC60849 A novel Rtg2p activity regulates nitrogen catabolism in yeast Michael M. Pierce, Marie-Lise Maddelein, B. Tibor Roberts, and Reed B. Wickner Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13213–13218. Published online 2001 October 30. doi: 10.1073/pnas.181486098.PMCID: PMC60850 Genetic variation in aldosterone synthase predicts plasma glucose levels Koustubh Ranade, Kwan Dun Wu, Neil Risch, Michael Olivier, Dee Pei, Chin-Fu Hsiao, Lee-Ming Chuang, Low-Tone Ho, Eric Jorgenson, Robert Pesich, Yii-Der I. Chen, Victor Dzau, Alfred Lin, Richard A. Olshen, David Curb, David R. Cox, and David Botstein Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13219–13224. Published online 2001 October 30. doi: 10.1073/pnas.221467098.PMCID: PMC60851 Identification of five new genes on the Y chromosome of Drosophila melanogaster Antonio Bernardo Carvalho, Bridget A. Dobo, Maria D. Vibranovski, and Andrew G. Clark Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13225–13230. Published online 2001 October 30. doi: 10.1073/pnas.231484998.PMCID: PMC60852 Genetic characterization of the body attributed to the evangelist Luke Cristiano Vernesi, Giulietta Di Benedetto, David Caramelli, Erica Secchieri, Lucia Simoni, Emile Katti, Patrizia Malaspina, Andrea Novelletto, Vito Terribile Wiel Marin, and Guido Barbujani Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13460–13463. Published online 2001 October 16. doi: 10.1073/pnas.211540498.PMCID: PMC60893 Immunology Structure of the interferon-receptor complex determined by distance constraints from double-mutant cycles and flexible docking Laila C. Roisman, Jacob Piehler, Jean-Yves Trosset, Harold A. Scheraga, and Gideon Schreiber Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13231–13236. doi: 10.1073/pnas.221290398.PMCID: PMC60853 The infiltration kinetics of simian immunodeficiency virus-specific T cells drawn to sites of high antigenic stimulation determines local in vivo viral escape Philippe Blancou, Nicole Chenciner, Marie-Christine Cumont, Simon Wain-Hobson, Bruno Hurtrel, and Rémi Cheynier Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13237–13242. Published online 2001 October 30. doi: 10.1073/pnas.231348598.PMCID: PMC60854 Th1-polarizing immunization with egg antigens correlates with severe exacerbation of immunopathology and death in schistosome infection Laura I. Rutitzky, Hector J. Hernandez, and Miguel J. Stadecker Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13243–13248. Published online 2001 October 23. doi: 10.1073/pnas.231258498.PMCID: PMC60855 IL-1β-converting enzyme (caspase-1) in intestinal inflammation Britta Siegmund, Hans-Anton Lehr, Giamila Fantuzzi, and Charles A. Dinarello Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13249–13254. Published online 2001 October 23. doi: 10.1073/pnas.231473998.PMCID: PMC60856 Frameshift-mutation-derived peptides as tumor-specific antigens in inherited and spontaneous colorectal cancer Ingvil Sæterdal, Jens Bjørheim, Kari Lislerud, Marianne K. Gjertsen, Ida K. Bukholm, Ole Christian Olsen, Jahn M. Nesland, Jon Amund Eriksen, Mona Møller, Annika Lindblom, and Gustav Gaudernack Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13255–13260. Published online 2001 October 30. doi: 10.1073/pnas.231326898.PMCID: PMC60857 Medical Sciences The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo Jian-Guo Zhang, Donald Metcalf, Steven Rakar, Maria Asimakis, Christopher J. Greenhalgh, Tracy A. Willson, Robyn Starr, Sandra E. Nicholson, Wendy Carter, Warren S. Alexander, Douglas J. Hilton, and Nicos A. Nicola Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13261–13265. Published online 2001 October 23. doi: 10.1073/pnas.231486498.PMCID: PMC60858 Project normal: Defining normal variance in mouse gene expression Colin C. Pritchard, Li Hsu, Jeffrey Delrow, and Peter S. Nelson Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13266–13271. doi: 10.1073/pnas.221465998.PMCID: PMC60859 Personality traits and brain dopaminergic function in Parkinson's disease Valtteri Kaasinen, Elina Nurmi, Jörgen Bergman, Olli Eskola, Olof Solin, Pirkko Sonninen, and Juha O. Rinne Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13272–13277. Published online 2001 October 30. doi: 10.1073/pnas.231313198.PMCID: PMC60860 Targeting Plasmodium ligands on mosquito salivary glands and midgut with a phage display peptide library Anil K. Ghosh, Paulo E. M. Ribolla, and Marcelo Jacobs-Lorena Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13278–13281. Published online 2001 October 30. doi: 10.1073/pnas.241491198.PMCID: PMC60861 Lifetime correction of genetic deficiency in mice with a single injection of helper-dependent adenoviral vector In-Hoo Kim, Alicja Józkowicz, Pedro A. Piedra, Kazuhiro Oka, and Lawrence Chan Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13282–13287. Published online 2001 October 30. doi: 10.1073/pnas.241506298.PMCID: PMC60862 Structured antiretroviral treatment interruptions in chronically HIV-1-infected subjects Gabriel M. Ortiz, Melissa Wellons, Jason Brancato, Ha T. T. Vo, Rebekah L. Zinn, Daniel E. Clarkson, Katherine Van Loon, Sebastian Bonhoeffer, G. Diego Miralles, David Montefiori, John A. Bartlett, and Douglas F. Nixon Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13288–13293. Published online 2001 October 30. doi: 10.1073/pnas.221452198.PMCID: PMC60863 Compared with saturated fatty acids, dietary monounsaturated fatty acids and carbohydrates increase atherosclerosis and VLDL cholesterol levels in LDL receptor-deficient, but not apolipoprotein E-deficient, mice Martin Merkel, Wanda Velez-Carrasco, Lisa C. Hudgins, and Jan L. Breslow Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13294–13299. Published online 2001 October 23. doi: 10.1073/pnas.231490498.PMCID: PMC60864 Delayed replication timing leads to delayed mitotic chromosome condensation and chromosomal instability of chromosome translocations Leslie Smith, Annemieke Plug, and Mathew Thayer Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13300–13305. doi: 10.1073/pnas.241355098.PMCID: PMC60865 Enterocolitis induced by autoimmune targeting of enteric glial cells: A possible mechanism in Crohn's disease? Anne Cornet, Tor C. Savidge, Julie Cabarrocas, Wen-Lin Deng, Jean-Frederic Colombel, Hans Lassmann, Pierre Desreumaux, and Roland S. Liblau Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13306–13311. Published online 2001 October 30. doi: 10.1073/pnas.231474098.PMCID: PMC60866 Invasive melanoma in Cdk4-targeted mice Rocío Sotillo, Juan F. García, Sagrario Ortega, Javier Martín, Pierre Dubus, Mariano Barbacid, and Marcos Malumbres Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13312–13317. Published online 2001 October 23. doi: 10.1073/pnas.241338598.PMCID: PMC60867 Expanded polyglutamines in Caenorhabditis elegans cause axonal abnormalities and severe dysfunction of PLM mechanosensory neurons without cell death J. Alex Parker, John B. Connolly, Cheryll Wellington, Michael Hayden, Jean Dausset, and Christian Neri Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13318–13323. Published online 2001 October 30. doi: 10.1073/pnas.231476398.PMCID: PMC60868 Duodenal calcium absorption in vitamin D receptor–knockout mice: Functional and molecular aspects Sophie J. Van Cromphaut, Mieke Dewerchin, Joost G. J. Hoenderop, Ingrid Stockmans, Erik Van Herck, Shigeaki Kato, René J. M. Bindels, Désiré Collen, Peter Carmeliet, Roger Bouillon, and Geert Carmeliet Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13324–13329. Published online 2001 October 30. doi: 10.1073/pnas.231474698.PMCID: PMC60869 Genetically increased angiotensin I-converting enzyme level and renal complications in the diabetic mouse Wei Huang, Yves Gallois, Nadine Bouby, Patrick Bruneval, Didier Heudes, Marie-France Belair, John H. Krege, Pierre Meneton, Michel Marre, Oliver Smithies, and François Alhenc-Gelas Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13330–13334. Published online 2001 October 30. doi: 10.1073/pnas.231476798.PMCID: PMC60870 Microbiology Use of a dynamic in vitro attachment and invasion system (DIVAS) to determine influence of growth rate on invasion of respiratory epithelial cells by group B Streptococcus Gennady Malin and Lawrence C. Paoletti Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13335–13340. Published online 2001 October 30. doi: 10.1073/pnas.241079098.PMCID: PMC60871 Viruses from extreme thermal environments George Rice, Kenneth Stedman, Jamie Snyder, Blake Wiedenheft, Debbie Willits, Susan Brumfield, Timothy McDermott, and Mark J. Young Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13341–13345. Published online 2001 October 23. doi: 10.1073/pnas.231170198.PMCID: PMC60872 Nitrogen cycling by wood decomposing soft-rot fungi in the “King Midas tomb,” Gordion, Turkey Timothy R. Filley, Robert A. Blanchette, Elizabeth Simpson, and Marilyn L. Fogel Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13346–13350. Published online 2001 October 23. doi: 10.1073/pnas.221299598.PMCID: PMC60873 Neurobiology INAUGURAL ARTICLE by a Recently Elected Academy Member: Increased sensitivity to cocaine by cholinergic cell ablation in nucleus accumbens Takatoshi Hikida, Satoshi Kaneko, Tomohiro Isobe, Yasuji Kitabatake, Dai Watanabe, Ira Pastan, and Shigetada Nakanishi Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13351–13354. Published online 2001 October 23. doi: 10.1073/pnas.231488998.PMCID: PMC60874 Altered psychomotor behaviors in mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP) Hitoshi Hashimoto, Norihito Shintani, Kazuhiro Tanaka, Wakaba Mori, Megumi Hirose, Toshio Matsuda, Masaki Sakaue, Jun-ichi Miyazaki, Hitoshi Niwa, Fumi Tashiro, Kyohei Yamamoto, Kazumi Koga, Shuhei Tomimoto, Akiyoshi Kunugi, Sayoko Suetake, and Akemichi Baba Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13355–13360. Published online 2001 October 30. doi: 10.1073/pnas.231094498.PMCID: PMC60875 Chromosomal variation in neurons of the developing and adult mammalian nervous system Stevens Kastrup Rehen, Michael J. McConnell, Dhruv Kaushal, Marcy A. Kingsbury, Amy H. Yang, and Jerold Chun Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13361–13366. doi: 10.1073/pnas.231487398.PMCID: PMC60876 Speech comprehension is correlated with temporal response patterns recorded from auditory cortex Ehud Ahissar, Srikantan Nagarajan, Merav Ahissar, Athanassios Protopapas, Henry Mahncke, and Michael M. Merzenich Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13367–13372. doi: 10.1073/pnas.201400998.PMCID: PMC60877 Distinct potassium channels on pain-sensing neurons Matthew N. Rasband, Eunice W. Park, Todd W. Vanderah, Josephine Lai, Frank Porreca, and James S. Trimmer Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13373–13378. doi: 10.1073/pnas.231376298.PMCID: PMC60878 Early postnatal ataxia and abnormal cerebellar development in mice lacking Xeroderma pigmentosum Group A and Cockayne Syndrome Group B DNA repair genes Machiko Murai, Yasushi Enokido, Naoko Inamura, Masafumi Yoshino, Yoshimichi Nakatsu, Gijsbertus T. J. van der Horst, Jan H. J. Hoeijmakers, Kiyoji Tanaka, and Hiroshi Hatanaka Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13379–13384. Published online 2001 October 30. doi: 10.1073/pnas.231329598.PMCID: PMC60879 c-Jun mediates axotomy-induced dopamine neuron death in vivo S. J. Crocker, W. R. Lamba, P. D. Smith, S. M. Callaghan, R. S. Slack, H. Anisman, and D. S. Park Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13385–13390. Published online 2001 October 30. doi: 10.1073/pnas.231177098.PMCID: PMC60880 Cyclic changes in estradiol regulate synaptic plasticity through the MAP kinase pathway Ruifen Bi, Michael R. Foy, Rose-Marie Vouimba, Richard F. Thompson, and Michel Baudry Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13391–13395. Published online 2001 October 30. doi: 10.1073/pnas.241507698.PMCID: PMC60881 Vanilloid receptor expression suggests a sensory role for urinary bladder epithelial cells Lori A. Birder, Anthony J. Kanai, William C. de Groat, Susanna Kiss, Michele L. Nealen, Nancy E. Burke, Kirk E. Dineley, Simon Watkins, Ian J. Reynolds, and Michael J. Caterina Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13396–13401. Published online 2001 October 23. doi: 10.1073/pnas.231243698.PMCID: PMC60882 Pharmacology Positive allosteric modulators of metabotropic glutamate 1 receptor: Characterization, mechanism of action, and binding site Frédéric Knoflach, Vincent Mutel, Synèse Jolidon, James N. C. Kew, Pari Malherbe, Eric Vieira, Jürgen Wichmann, and John A. Kemp Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13402–13407. Published online 2001 October 23. doi: 10.1073/pnas.231358298.PMCID: PMC60883 Physiology A paradox resolved: Sulfide acquisition by roots of seep tubeworms sustains net chemoautotrophy John K. Freytag, Peter R. Girguis, Derk C. Bergquist, Jason P. Andras, James J. Childress, and Charles R. Fisher Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13408–13413. Published online 2001 October 30. doi: 10.1073/pnas.231589498.PMCID: PMC60884 The expression of the γ subunit of Na-K-ATPase is regulated by osmolality via C-terminal Jun kinase and phosphatidylinositol 3-kinase-dependent mechanisms J. M. Capasso, C. Rivard, and T. Berl Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13414–13419. Published online 2001 October 30. doi: 10.1073/pnas.231309198.PMCID: PMC60885 Ouabain, a steroid hormone that signals with slow calcium oscillations Oleg Aizman, Per Uhlén, Mark Lal, Hjalmar Brismar, and Anita Aperia Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13420–13424. Published online 2001 October 30. doi: 10.1073/pnas.221315298.PMCID: PMC60886 Plant Biology Structural requirements of endopolygalacturonase for the interaction with PGIP (polygalacturonase-inhibiting protein) L. Federici, C. Caprari, B. Mattei, C. Savino, A. Di Matteo, G. De Lorenzo, F. Cervone, and D. Tsernoglou Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13425–13430. Published online 2001 October 30. doi: 10.1073/pnas.231473698.PMCID: PMC60887 A new class of oxidosqualene cyclases directs synthesis of antimicrobial phytoprotectants in monocots K. Haralampidis, G. Bryan, X. Qi, K. Papadopoulou, S. Bakht, R. Melton, and A. Osbourn Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13431–13436. Published online 2001 October 23. doi: 10.1073/pnas.231324698.PMCID: PMC60888 RNAi-mediated oncogene silencing confers resistance to crown gall tumorigenesis Matthew A. Escobar, Edwin L. Civerolo, Kristin R. Summerfelt, and Abhaya M. Dandekar Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13437–13442. Published online 2001 October 30. doi: 10.1073/pnas.241276898.PMCID: PMC60889 The initial steps of biogenesis of cyanobacterial photosystems occur in plasma membranes Elena Zak, Birgitta Norling, Radhashree Maitra, Fang Huang, Bertil Andersson, and Himadri B. Pakrasi Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13443–13448. Published online 2001 October 30. doi: 10.1073/pnas.241503898.PMCID: PMC60890 The plant oncogene rolD encodes a functional ornithine cyclodeaminase Maurizio Trovato, Bruno Maras, Francisco Linhares, and Paolo Costantino Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13449–13453. Published online 2001 October 30. doi: 10.1073/pnas.231320398.PMCID: PMC60891 Signal interactions between nitric oxide and reactive oxygen intermediates in the plant hypersensitive disease resistance response Massimo Delledonne, Jürgen Zeier, Adriano Marocco, and Chris Lamb Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13454–13459. Published online 2001 October 23. doi: 10.1073/pnas.231178298.PMCID: PMC60892 Social Sciences Anthropology Paternity and relatedness in wild chimpanzee communities Linda Vigilant, Michael Hofreiter, Heike Siedel, and Christophe Boesch Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 12890–12895. Published online 2001 October 23. doi: 10.1073/pnas.231320498.PMCID: PMC60795 Nitrogen cycling by wood decomposing soft-rot fungi in the “King Midas tomb,” Gordion, Turkey Timothy R. Filley, Robert A. Blanchette, Elizabeth Simpson, and Marilyn L. Fogel Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13346–13350. Published online 2001 October 23. doi: 10.1073/pnas.221299598.PMCID: PMC60873 Genetic characterization of the body attributed to the evangelist Luke Cristiano Vernesi, Giulietta Di Benedetto, David Caramelli, Erica Secchieri, Lucia Simoni, Emile Katti, Patrizia Malaspina, Andrea Novelletto, Vito Terribile Wiel Marin, and Guido Barbujani Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13460–13463. Published online 2001 October 16. doi: 10.1073/pnas.211540498.PMCID: PMC60893 Psychology INAUGURAL ARTICLE by a Recently Elected Academy Member: Spoken word production: A theory of lexical access Willem J. M. Levelt Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13464–13471. doi: 10.1073/pnas.231459498.PMCID: PMC60894 Corrections Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13472. PMCID: PMC60895 Corrects: Qing-Xin Hua, et al. Diabetes-associated mutations in a β-cell transcription factor destabilize an antiparallel “mini-zipper” in a dimerization interface. Proc Natl Acad Sci U S A. 2000 February 29; 97(5): 1999–2004. Proc Natl Acad Sci U S A. 2001 November 6; 98(23): 13472. PMCID: PMC60896 Corrects: Emma E. Hamilton-Williams, et al. Transgenic rescue implicates β2-microglobulin as a
diabetes susceptibility gene in nonobese diabetic (NOD) mice. Proc Natl Acad Sci U S A. 2001 September 25; 98(20): 11533–11538. |