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Volume 98(22);  October 23, 2001
From the Academy
Japanese-American Frontiers of Science Symposium
Introduction to the Japanese–American Frontiers of Science
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12337. Published online 2001 October 16. doi: 10.1073/pnas.231383098.
PMCID: PMC60051
Body patterning
Yoshiko Takahashi, Noriko Osumi, and Nipam H. Patel
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12338–12339. Published online 2001 October 16. doi: 10.1073/pnas.221383198.
PMCID: PMC60052
What visual perception tells us about mind and brain
Shinsuke Shimojo, Michael Paradiso, and Ichiro Fujita
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12340–12341. Published online 2001 October 16. doi: 10.1073/pnas.221383698.
PMCID: PMC60053
Chaos and stability of the solar system
Renu Malhotra, Matthew Holman, and Takashi Ito
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12342–12343. Published online 2001 October 16. doi: 10.1073/pnas.231384098.
PMCID: PMC60054
Multiscale computing
Mei Kobayashi, Toshio Irino, and Wim Sweldens
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12344–12345. Published online 2001 October 16. doi: 10.1073/pnas.231384298.
PMCID: PMC60055
Commentaries
PIFs meet Tourists and Harbingers: A superfamily reunion
Jerzy Jurka and Vladimir V. Kapitonov
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12315–12316. doi: 10.1073/pnas.231490598.
PMCID: PMC60043
Cyclopentenone signals for plant defense: Remodeling the jasmonic acid response
Gregg A. Howe
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12317–12319. doi: 10.1073/pnas.231480898.
PMCID: PMC60044
Depression, antidepressants, and the shrinking hippocampus
Robert M. Sapolsky
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12320–12322. doi: 10.1073/pnas.231475998.
PMCID: PMC60045
Telling tails
Mary B. Kennedy and Pat Manzerra
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12323–12324. doi: 10.1073/pnas.231486398.
PMCID: PMC60046
From the Cover:
Crosstalk of the group IIa and IIb metals calcium and zinc in cellular signaling
Wolfgang Maret
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12325–12327. doi: 10.1073/pnas.231481398.
PMCID: PMC60047
Bt or not Bt: Is that the question?
J. Mark Scriber
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12328–12330. doi: 10.1073/pnas.241503398.
PMCID: PMC60048
How do tumors make ends meet?
Christoph Lengauer
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12331–12333. doi: 10.1073/pnas.231485898.
PMCID: PMC60049
The intestinal stem cell niche: There grows the neighborhood
Jason C. Mills and Jeffrey I. Gordon
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12334–12336. doi: 10.1073/pnas.231487198.
PMCID: PMC60050
Physical Sciences
Applied Mathematics
Statistical equilibrium predictions of jets and spots on Jupiter
Bruce Turkington, Andrew Majda, Kyle Haven, and Mark DiBattista
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12346–12350. Published online 2001 October 9. doi: 10.1073/pnas.221449898.
PMCID: PMC60056
THEMATICS: A simple computational predictor of enzyme function from structure
Mary Jo Ondrechen, James G. Clifton, and Dagmar Ringe
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12473–12478. Published online 2001 October 16. doi: 10.1073/pnas.211436698.
PMCID: PMC60078
Chemistry
Conformation-family Monte Carlo: A new method for crystal structure prediction
Jaroslaw Pillardy, Yelena A. Arnautova, Cezary Czaplewski, Kenneth D. Gibson, and Harold A. Scheraga
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12351–12356. Published online 2001 October 16. doi: 10.1073/pnas.231479298.
PMCID: PMC60057
Biological Sciences
Biochemistry
An optomechanical transducer in the blue light receptor phototropin from Avena sativa
Michael Salomon, Wolfgang Eisenreich, Harald Dürr, Erik Schleicher, Elke Knieb, Vincent Massey, Wolfhart Rüdiger, Franz Müller, Adelbert Bacher, and Gerald Richter
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12357–12361. Published online 2001 October 16. doi: 10.1073/pnas.221455298.
PMCID: PMC60058
J3-crystallin of the jellyfish lens: Similarity to saposins
Joram Piatigorsky, Barbara Norman, Larry J. Dishaw, Lidia Kos, Joseph Horwitz, Peter J. Steinbach, and Zbynek Kozmik
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12362–12367. doi: 10.1073/pnas.231310698.
PMCID: PMC60059
Tetrahymena proteins p80 and p95 are not core telomerase components
Douglas X. Mason, Chantal Autexier, and Carol W. Greider
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12368–12373. Published online 2001 October 9. doi: 10.1073/pnas.221456398.
PMCID: PMC60060
Large libraries reveal diverse solutions to an RNA recognition problem
Jeffrey E. Barrick, Terry T. Takahashi, Jinsong Ren, Tianbing Xia, and Richard W. Roberts
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12374–12378. doi: 10.1073/pnas.221467798.
PMCID: PMC60061
p53 is a potential mediator of pregnancy and hormone-induced resistance to mammary carcinogenesis
Lakshmi Sivaraman, Orla M. Conneely, Daniel Medina, and Bert W. O'Malley
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12379–12384. Published online 2001 October 16. doi: 10.1073/pnas.221459098.
PMCID: PMC60062
Cross-talk between sympathetic neurons and adipocytes in coculture
L. Christine Turtzo, Ruth Marx, and M. Daniel Lane
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12385–12390. Published online 2001 October 16. doi: 10.1073/pnas.231478898.
PMCID: PMC60063
Accumulation of cholera toxin and GM1 ganglioside in the early endosome of Niemann–Pick C1-deficient cells
Yuko Sugimoto, Haruaki Ninomiya, Yuki Ohsaki, Katsumi Higaki, Joanna P. Davies, Yiannis A. Ioannou, and Kousaku Ohno
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12391–12396. doi: 10.1073/pnas.221181998.
PMCID: PMC60064
Arg-735 of the 100-kDa subunit a of the yeast V-ATPase is essential for proton translocation
Shoko Kawasaki-Nishi, Tsuyoshi Nishi, and Michael Forgac
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12397–12402. Published online 2001 October 9. doi: 10.1073/pnas.221291798.
PMCID: PMC60065
Segmentation gene product Fushi tarazu is an LXXLL motif-dependent coactivator for orphan receptor FTZ-F1
Taiga Suzuki, Haruhisa Kawasaki, Ruth T. Yu, Hitoshi Ueda, and Kazuhiko Umesono
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12403–12408. Published online 2001 October 9. doi: 10.1073/pnas.221552998.
PMCID: PMC60066
Deamidation of human proteins
N. E. Robinson and A. B. Robinson
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12409–12413. Published online 2001 October 16. doi: 10.1073/pnas.221463198.
PMCID: PMC60067
Mono(ADP-ribosyl)ation of 2′-deoxyguanosine residue in DNA by an apoptosis-inducing protein, pierisin-1, from cabbage butterfly
Takeji Takamura-Enya, Masahiko Watanabe, Yukari Totsuka, Takashi Kanazawa, Yuko Matsushima-Hibiya, Kotaro Koyama, Takashi Sugimura, and Keiji Wakabayashi
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12414–12419. Published online 2001 October 9. doi: 10.1073/pnas.221444598.
PMCID: PMC60068
Probing the open state of cytochrome P450cam with ruthenium-linker substrates
Alexander R. Dunn, Ivan J. Dmochowski, Alexandrine M. Bilwes, Harry B. Gray, and Brian R. Crane
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12420–12425. Published online 2001 October 16. doi: 10.1073/pnas.221297998.
PMCID: PMC60069
Sequential recruitment of steroid receptor coactivator-1 (SRC-1) and p300 enhances progesterone receptor-dependent initiation and reinitiation of transcription from chromatin
Zheng Liu, Jiemin Wong, Sophia Y. Tsai, Ming-Jer Tsai, and Bert W. O'Malley
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12426–12431. Published online 2001 October 16. doi: 10.1073/pnas.231474798.
PMCID: PMC60070
TAFII55 binding to TAFII250 inhibits its acetyltransferase activity
Anne Gegonne, Jocelyn D. Weissman, and Dinah S. Singer
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12432–12437. Published online 2001 October 9. doi: 10.1073/pnas.211444798.
PMCID: PMC60071
Peptides from the amino terminal mdm-2-binding domain of p53, designed from conformational analysis, are selectively cytotoxic to transformed cells
Mecheal Kanovsky, Anthony Raffo, Lisa Drew, Ramon Rosal, Tamara Do, Fred K. Friedman, Pablo Rubinstein, Jan Visser, Richard Robinson, Paul W. Brandt-Rauf, Josef Michl, Robert L. Fine, and Matthew R. Pincus
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12438–12443. Published online 2001 October 16. doi: 10.1073/pnas.211280698.
PMCID: PMC60072
A human nuclease specific for G4 DNA
Hui Sun, Akiko Yabuki, and Nancy Maizels
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12444–12449. doi: 10.1073/pnas.231479198.
PMCID: PMC60073
The kinetic basis of peptide exchange catalysis by HLA-DM
Jennifer A. Zarutskie, Robert Busch, Zarixia Zavala-Ruiz, Mia Rushe, Elizabeth D. Mellins, and Lawrence J. Stern
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12450–12455. Published online 2001 October 16. doi: 10.1073/pnas.211439398.
PMCID: PMC60074
Biophysics
A thermodynamic framework for Mg2+ binding to RNA
Vinod K. Misra and David E. Draper
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12456–12461. doi: 10.1073/pnas.221234598.
PMCID: PMC60075
Oligomerization of the integrin αIIbβ3: Roles of the transmembrane and cytoplasmic domains
Renhao Li, Charles R. Babu, James D. Lear, A. Joshua Wand, Joel S. Bennett, and William F. DeGrado
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12462–12467. Published online 2001 October 16. doi: 10.1073/pnas.221463098.
PMCID: PMC60076
A high-speed atomic force microscope for studying biological macromolecules
Toshio Ando, Noriyuki Kodera, Eisuke Takai, Daisuke Maruyama, Kiwamu Saito, and Akitoshi Toda
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12468–12472. Published online 2001 October 9. doi: 10.1073/pnas.211400898.
PMCID: PMC60077
THEMATICS: A simple computational predictor of enzyme function from structure
Mary Jo Ondrechen, James G. Clifton, and Dagmar Ringe
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12473–12478. Published online 2001 October 16. doi: 10.1073/pnas.211436698.
PMCID: PMC60078
Water magnetic relaxation dispersion in biological systems: The contribution of proton exchange and implications for the noninvasive detection of cartilage degradation
Umamaheswar Duvvuri, Ari D. Goldberg, James K. Kranz, Linh Hoang, Ravinder Reddy, Felix W. Wehrli, A. Joshua Wand, S. W. Englander, and John S. Leigh
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12479–12484. Published online 2001 October 16. doi: 10.1073/pnas.221471898.
PMCID: PMC60079
Cell Biology
Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor
Juan Carlos Rodríguez-Manzaneque, Timothy F. Lane, María Asunción Ortega, Richard O. Hynes, Jack Lawler, and M. Luisa Iruela-Arispe
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12485–12490. Published online 2001 October 16. doi: 10.1073/pnas.171460498.
PMCID: PMC60080
Megalin-dependent cubilin-mediated endocytosis is a major pathway for the apical uptake of transferrin in polarized epithelia
Renata Kozyraki, John Fyfe, Pierre J. Verroust, Christian Jacobsen, Alice Dautry-Varsat, Jakub Gburek, Thomas E. Willnow, Erik Ilsø Christensen, and Søren K. Moestrup
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12491–12496. Published online 2001 October 16. doi: 10.1073/pnas.211291398.
PMCID: PMC60081
Modulation of specific intestinal epithelial progenitors by enteric neurons
Matthew Bjerknes and Hazel Cheng
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12497–12502. Published online 2001 September 25. doi: 10.1073/pnas.211278098.
PMCID: PMC60082
Overexpression of cellular glutathione peroxidase rescues homocyst(e)ine-induced endothelial dysfunction
Norbert Weiss, Ying-Yi Zhang, Stanley Heydrick, Charlene Bierl, and Joseph Loscalzo
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12503–12508. Published online 2001 October 16. doi: 10.1073/pnas.231428998.
PMCID: PMC60083
Endostatin regulates branching morphogenesis of renal epithelial cells and ureteric bud
Anil Karihaloo, S. Ananth Karumanchi, Jonathan Barasch, Vivekanand Jha, Christian Hans Nickel, Jun Yang, Silviu Grisaru, Kevin T. Bush, Sanjay Nigam, Norman D. Rosenblum, Vikas P. Sukhatme, and Lloyd G. Cantley
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12509–12514. Published online 2001 October 16. doi: 10.1073/pnas.221205198.
PMCID: PMC60084
Degradation of the kinesin Kip1p at anaphase onset is mediated by the anaphase-promoting complex and Cdc20p
Donna M. Gordon and David M. Roof
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12515–12520. Published online 2001 October 16. doi: 10.1073/pnas.231212498.
PMCID: PMC60085
Developmental Biology
Sonic hedgehog restricts adhesion and migration of neural crest cells independently of the Patched- Smoothened-Gli signaling pathway
Sandrine Testaz, Artem Jarov, Kevin P. Williams, Leona E. Ling, Victor E. Koteliansky, Claire Fournier-Thibault, and Jean-Loup Duband
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12521–12526. Published online 2001 October 9. doi: 10.1073/pnas.221108698.
PMCID: PMC60086
A voltage-gated ion channel expressed specifically in spermatozoa
Timothy A. Quill, Dejian Ren, David E. Clapham, and David L. Garbers
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12527–12531. doi: 10.1073/pnas.221454998.
PMCID: PMC60087
C/EBPα is required for differentiation of white, but not brown, adipose tissue
Heinz G. Linhart, Kazumi Ishimura-Oka, Franco DeMayo, Tetsuya Kibe, David Repka, Brian Poindexter, Roger J. Bick, and Gretchen J. Darlington
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12532–12537. Published online 2001 October 16. doi: 10.1073/pnas.211416898.
PMCID: PMC60088
Development of a two-part transcription probe to determine the completeness of temporal and spatial compartmentalization of gene expression during bacterial development
Zusheng Li and Patrick J. Piggot
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12538–12543. Published online 2001 October 16. doi: 10.1073/pnas.221454798.
PMCID: PMC60089
Ecology
From the Cover:
Long-term changes in Serengeti-Mara wildebeest and land cover: Pastoralism, population, or policies?
K. Homewood, E. F. Lambin, E. Coast, A. Kariuki, I. Kikula, J. Kivelia, M. Said, S. Serneels, and M. Thompson
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12544–12549. doi: 10.1073/pnas.221053998.
PMCID: PMC60090
Evolution
Metabolic rate and environmental productivity: Well-provisioned animals evolved to run and idle fast
Pamela Mueller and Jared Diamond
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12550–12554. Published online 2001 October 16. doi: 10.1073/pnas.221456698.
PMCID: PMC60091
A newly discovered bacterium associated with parthenogenesis and a change in host selection behavior in parasitoid wasps
E. Zchori-Fein, Y. Gottlieb, S. E. Kelly, J. K. Brown, J. M. Wilson, T. L. Karr, and M. S. Hunter
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12555–12560. Published online 2001 October 9. doi: 10.1073/pnas.221467498.
PMCID: PMC60092
Density-dependent competition and selection on immune function in genetic lizard morphs
Erik Svensson, Barry Sinervo, and Tosha Comendant
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12561–12565. Published online 2001 October 9. doi: 10.1073/pnas.211071298.
PMCID: PMC60093
Genetics
Spontaneous hepatocellular carcinoma is reduced in transgenic mice overexpressing human O6- methylguanine-DNA methyltransferase
Zi-Qiang Zhou, Diwi Manguino, Kristen Kewitt, Gabriel W. Intano, C. Alex McMahan, Damon C. Herbert, Martha Hanes, Robert Reddick, Yuji Ikeno, and Christi A. Walter
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12566–12571. Published online 2001 October 16. doi: 10.1073/pnas.221232998.
PMCID: PMC60094
From the Cover:
P instability factor: An active maize transposon system associated with the amplification of Tourist-like MITEs and a new superfamily of transposases
Xiaoyu Zhang, Cédric Feschotte, Qiang Zhang, Ning Jiang, William B. Eggleston, and Susan R. Wessler
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12572–12577. Published online 2001 October 2. doi: 10.1073/pnas.211442198.
PMCID: PMC60095
Chemical inhibition of the Pho85 cyclin-dependent kinase reveals a role in the environmental stress response
Adam S. Carroll, Anthony C. Bishop, Joseph L. DeRisi, Kevan M. Shokat, and Erin K. O'Shea
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12578–12583. doi: 10.1073/pnas.211195798.
PMCID: PMC60096
Correction of the retinal dystrophy phenotype of the RCS rat by viral gene transfer of Mertk
Douglas Vollrath, Wei Feng, Jacque L. Duncan, Douglas Yasumura, Patricia M. D'Cruz, Aimee Chappelow, Michael T. Matthes, Mark A. Kay, and Matthew M. LaVail
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12584–12589. Published online 2001 October 9. doi: 10.1073/pnas.221364198.
PMCID: PMC60097
Genome-wide analysis of the Drosophila immune response by using oligonucleotide microarrays
Ennio De Gregorio, Paul T. Spellman, Gerald M. Rubin, and Bruno Lemaitre
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12590–12595. Published online 2001 October 16. doi: 10.1073/pnas.221458698.
PMCID: PMC60098
A conditional tissue-specific transgene expression system using inducible GAL4
Thomas Osterwalder, Kenneth S. Yoon, Benjamin H. White, and Haig Keshishian
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12596–12601. doi: 10.1073/pnas.221303298.
PMCID: PMC60099
P{Switch}, a system for spatial and temporal control of gene expression in Drosophila melanogaster
Gregg Roman, Keita Endo, Lin Zong, and Ronald L. Davis
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12602–12607. doi: 10.1073/pnas.221303998.
PMCID: PMC60100
A genome-wide screen in Saccharomyces cerevisiae for genes affecting UV radiation sensitivity
Geoff W. Birrell, Guri Giaever, Angela M. Chu, Ronald W. Davis, and J. Martin Brown
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12608–12613. Published online 2001 October 16. doi: 10.1073/pnas.231366398.
PMCID: PMC60101
Immunology
Mutations of CD40 gene cause an autosomal recessive form of immunodeficiency with hyper IgM
Simona Ferrari, Silvia Giliani, Antonella Insalaco, Abdulaziz Al-Ghonaium, Anna R. Soresina, Michael Loubser, Maria A. Avanzini, Massimo Marconi, Raffaele Badolato, Alberto G. Ugazio, Yves Levy, Nadia Catalan, Anne Durandy, Abdelghani Tbakhi, Luigi D. Notarangelo, and Alessandro Plebani
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12614–12619. doi: 10.1073/pnas.221456898.
PMCID: PMC60102
A hallmark of active class switch recombination: Transcripts directed by I promoters on looped-out circular DNAs
Kazuo Kinoshita, Motoko Harigai, Sidonia Fagarasan, Masamichi Muramatsu, and Tasuku Honjo
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12620–12623. Published online 2001 October 16. doi: 10.1073/pnas.221454398.
PMCID: PMC60103
Formation of supramolecular activation clusters on fresh ex vivo CD8+ T cells after engagement of the T cell antigen receptor and CD8 by antigen-presenting cells
Terry A. Potter, Kristie Grebe, Ben Freiberg, and Abraham Kupfer
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12624–12629. Published online 2001 October 16. doi: 10.1073/pnas.221458898.
PMCID: PMC60104
Gambicin: A novel immune responsive antimicrobial peptide from the malaria vector Anopheles gambiae
Jacopo Vizioli, Philippe Bulet, Jules A. Hoffmann, Fotis C. Kafatos, Hans-Michael Müller, and George Dimopoulos
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12630–12635. Published online 2001 October 16. doi: 10.1073/pnas.221466798.
PMCID: PMC60105
Natural killer T cells reactive to a single glycolipid exhibit a highly diverse T cell receptor β repertoire and small clone size
Jennifer L. Matsuda, Laurent Gapin, Nicolas Fazilleau, Kris Warren, Olga V. Naidenko, and Mitchell Kronenberg
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12636–12641. Published online 2001 October 9. doi: 10.1073/pnas.221445298.
PMCID: PMC60106
The nature of the active suppression of responses associated with experimental autoimmune myasthenia gravis by a dual altered peptide ligand administered by different routes
Miri Paas-Rozner, Michael Sela, and Edna Mozes
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12642–12647. Published online 2001 October 16. doi: 10.1073/pnas.221456798.
PMCID: PMC60107
Tsetse immune responses and trypanosome transmission: Implications for the development of tsetse-based strategies to reduce trypanosomiasis
Zhengrong Hao, Irene Kasumba, Michael J. Lehane, Wendy C. Gibson, Johnny Kwon, and Serap Aksoy
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12648–12653. Published online 2001 October 9. doi: 10.1073/pnas.221363798.
PMCID: PMC60108
Drosophila MyD88 is an adapter in the Toll signaling pathway
Tiffany Horng and Ruslan Medzhitov
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12654–12658. Published online 2001 October 16. doi: 10.1073/pnas.231471798.
PMCID: PMC60109
Medical Sciences
The tumor-infiltrating B cell response in medullary breast cancer is oligoclonal and directed against the autoantigen actin exposed on the surface of apoptotic cancer cells
Margit H. Hansen, Heidi Nielsen, and Henrik J. Ditzel
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12659–12664. Published online 2001 October 16. doi: 10.1073/pnas.171460798.
PMCID: PMC60110
Dose-dependent and independent temporal patterns of gene responses to ionizing radiation in normal and tumor cells and tumor xenografts
Nikolai N. Khodarev, James O. Park, Jianqing Yu, Nalin Gupta, Edwardine Nodzenski, Bernard Roizman, and Ralph R. Weichselbaum
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12665–12670. doi: 10.1073/pnas.211443698.
PMCID: PMC60111
Mechanism of indinavir-induced hyperbilirubinemia
Stephen D. Zucker, Xiaofa Qin, Susan D. Rouster, Fei Yu, Richard M. Green, Pavitra Keshavan, Judith Feinberg, and Kenneth E. Sherman
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12671–12676. Published online 2001 October 16. doi: 10.1073/pnas.231140698.
PMCID: PMC60112
A model for gene therapy of human hereditary lymphedema
Marika J. Karkkainen, Anne Saaristo, Lotta Jussila, Kaisa A. Karila, Elizabeth C. Lawrence, Katri Pajusola, Hansruedi Bueler, Anne Eichmann, Risto Kauppinen, Mikko I. Kettunen, Seppo Ylä-Herttuala, David N. Finegold, Robert E. Ferrell, and Kari Alitalo
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12677–12682. Published online 2001 October 9. doi: 10.1073/pnas.221449198.
PMCID: PMC60113
Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors
David Gisselsson, Tord Jonson, Åsa Petersén, Bodil Strömbeck, Paola Dal Cin, Mattias Höglund, Felix Mitelman, Fredrik Mertens, and Nils Mandahl
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12683–12688. Published online 2001 October 2. doi: 10.1073/pnas.211357798.
PMCID: PMC60114
Evolution of a unique Plasmodium falciparum chloroquine-resistance phenotype in association with pfcrt polymorphism in Papua New Guinea and South America
Rajeev K. Mehlotra, Hisashi Fujioka, Paul D. Roepe, Omar Janneh, Lyann M. B. Ursos, Vanessa Jacobs-Lorena, David T. McNamara, Moses J. Bockarie, James W. Kazura, Dennis E. Kyle, David A. Fidock, and Peter A. Zimmerman
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12689–12694. doi: 10.1073/pnas.221440898.
PMCID: PMC60115
Impaired response to HAART in HIV-infected individuals with high autonomic nervous system activity
Steve W. Cole, Bruce D. Naliboff, Margaret E. Kemeny, Marshall P. Griswold, John L. Fahey, and Jerome A. Zack
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12695–12700. doi: 10.1073/pnas.221134198.
PMCID: PMC60116
Microbiology
The Lassa virus glycoprotein precursor GP-C is proteolytically processed by subtilase SKI-1/S1P
Oliver Lenz, Jan ter Meulen, Hans-Dieter Klenk, Nabil G. Seidah, and Wolfgang Garten
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12701–12705. Published online 2001 October 16. doi: 10.1073/pnas.221447598.
PMCID: PMC60117
Mycobacterium tuberculosis signal transduction system required for persistent infections
Thomas C. Zahrt and Vojo Deretic
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12706–12711. doi: 10.1073/pnas.221272198.
PMCID: PMC60118
Comprehensive identification of conditionally essential genes in mycobacteria
Christopher M. Sassetti, Dana H. Boyd, and Eric J. Rubin
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12712–12717. Published online 2001 October 16. doi: 10.1073/pnas.231275498.
PMCID: PMC60119
SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-1 infection in vitro and in vivo
Julie M. Strizki, Serena Xu, Nicole E. Wagner, Lisa Wojcik, Jia Liu, Yan Hou, Michael Endres, Anandan Palani, Sherry Shapiro, John W. Clader, William J. Greenlee, Jayaram R. Tagat, Stuart McCombie, Kathleen Cox, Ahmad B. Fawzi, Chuan-Chu Chou, Catherine Pugliese-Sivo, Liza Davies, Mary E. Moreno, David D. Ho, Alexandra Trkola, Cheryl A. Stoddart, John P. Moore, Gregory R. Reyes, and Bahige M. Baroudy
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12718–12723. Published online 2001 October 16. doi: 10.1073/pnas.221375398.
PMCID: PMC60120
Expression of Borrelia burgdorferi OspC and DbpA is controlled by a RpoN–RpoS regulatory pathway
Anette Hübner, Xiaofeng Yang, Dena M. Nolen, Taissia G. Popova, Felipe C. Cabello, and Michael V. Norgard
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12724–12729. doi: 10.1073/pnas.231442498.
PMCID: PMC60121
Neurobiology
Transient uptake of serotonin by newborn olfactory projection neurons
Barbara S. Beltz, Jeanne L. Benton, and Jeremy M. Sullivan
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12730–12735. doi: 10.1073/pnas.231471298.
PMCID: PMC60122
Naturally occurring variations in maternal behavior in the rat are associated with differences in estrogen-inducible central oxytocin receptors
Frances Champagne, Josie Diorio, Shakti Sharma, and Michael J. Meaney
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12736–12741. Published online 2001 October 16. doi: 10.1073/pnas.221224598.
PMCID: PMC60123
From the Cover:
Regulation of NMDA receptors by cyclin-dependent kinase-5
Bing-Sheng Li, Miao-Kun Sun, Lei Zhang, Satoru Takahashi, Wu Ma, Lucia Vinade, Ashok B. Kulkarni, Roscoe O. Brady, and Harish C. Pant
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12742–12747. Published online 2001 October 2. doi: 10.1073/pnas.211428098.
PMCID: PMC60124
Visualizing recycling synaptic vesicles in hippocampal neurons by FM 1-43 photoconversion
Nobutoshi Harata, Timothy A. Ryan, Stephen J Smith, JoAnn Buchanan, and Richard W. Tsien
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12748–12753. doi: 10.1073/pnas.171442798.
PMCID: PMC60125
Brain-specific expression of an exogenous gene after i.v. administration
Ningya Shi, Yun Zhang, Chunni Zhu, Ruben J. Boado, and William M. Pardridge
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12754–12759. Published online 2001 October 9. doi: 10.1073/pnas.221450098.
PMCID: PMC60126
When zero is not zero: The problem of ambiguous baseline conditions in fMRI
Craig E. L. Stark and Larry R. Squire
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12760–12766. Published online 2001 October 9. doi: 10.1073/pnas.221462998.
PMCID: PMC60127
Functional magnetic resonance imaging of reorganization in rat brain after stroke
Rick M. Dijkhuizen, JingMei Ren, Joseph B. Mandeville, Ona Wu, Fatih M. Ozdag, Michael A. Moskowitz, Bruce R. Rosen, and Seth P. Finklestein
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12766–12771. Published online 2001 October 16. doi: 10.1073/pnas.231235598.
PMCID: PMC60128
A biophysical model of bidirectional synaptic plasticity: Dependence on AMPA and NMDA receptors
Gastone C. Castellani, Elizabeth M. Quinlan, Leon N Cooper, and Harel Z. Shouval
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12772–12777. doi: 10.1073/pnas.201404598.
PMCID: PMC60129
Auditory representation of the vocal repertoire in a songbird with multiple song types
Richard Mooney, William Hoese, and Stephen Nowicki
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12778–12783. doi: 10.1073/pnas.221453298.
PMCID: PMC60130
Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis
Yun J. Kim, Yong Yi, Ellen Sapp, Yumei Wang, Ben Cuiffo, Kimberly B. Kegel, Zheng-Hong Qin, Neil Aronin, and Marian DiFiglia
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12784–12789. doi: 10.1073/pnas.221451398.
PMCID: PMC60131
Point mutation in the mouse glucocorticoid receptor preventing DNA binding impairs spatial memory
Melly S. Oitzl, Holger M. Reichardt, Marian Joëls, and E. Ronald de Kloet
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12790–12795. Published online 2001 October 16. doi: 10.1073/pnas.231313998.
PMCID: PMC60132
Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine
Boldizsár Czéh, Thomas Michaelis, Takashi Watanabe, Jens Frahm, Gabriel de Biurrun, Marja van Kampen, Alessandro Bartolomucci, and Eberhard Fuchs
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12796–12801. Published online 2001 October 2. doi: 10.1073/pnas.211427898.
PMCID: PMC60133
Pharmacology
Role of p42/p44 mitogen-activated-protein kinase and p21waf1/cip1 in the regulation of vascular smooth muscle cell proliferation by nitric oxide
Philip M. Bauer, Georgette M. Buga, and Louis J. Ignarro
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12802–12807. Published online 2001 October 9. doi: 10.1073/pnas.211443198.
PMCID: PMC60134
Physiology
A role for frequenin, a Ca2+-binding protein, as a regulator of Kv4 K+-currents
Tomoe Y. Nakamura, David J. Pountney, Ander Ozaita, Sumon Nandi, Stefanie Ueda, Bernardo Rudy, and William A. Coetzee
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12808–12813. Published online 2001 October 16. doi: 10.1073/pnas.221168498.
PMCID: PMC60135
Plasma nitrite rather than nitrate reflects regional endothelial nitric oxide synthase activity but lacks intrinsic vasodilator action
Thomas Lauer, Michael Preik, Tienush Rassaf, Bodo E. Strauer, Andreas Deussen, Martin Feelisch, and Malte Kelm
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12814–12819. Published online 2001 October 16. doi: 10.1073/pnas.221381098.
PMCID: PMC60136
Plant Biology
Elimination of ergovaline from a grass–Neotyphodium endophyte symbiosis by genetic modification of the endophyte
Daniel G. Panaccione, Richard D. Johnson, Jinghong Wang, Carolyn A. Young, Prapassorn Damrongkool, Barry Scott, and Christopher L. Schardl
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12820–12825. Published online 2001 October 9. doi: 10.1073/pnas.221198698.
PMCID: PMC60137
FLU: A negative regulator of chlorophyll biosynthesis in Arabidopsis thaliana
Rasa Meskauskiene, Mena Nater, David Goslings, Felix Kessler, Roel op den Camp, and Klaus Apel
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12826–12831. Published online 2001 October 16. doi: 10.1073/pnas.221252798.
PMCID: PMC60138
Engineering salt-tolerant Brassica plants: Characterization of yield and seed oil quality in transgenic plants with increased vacuolar sodium accumulation
Hong-Xia Zhang, Joanna N. Hodson, John P. Williams, and Eduardo Blumwald
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12832–12836. Published online 2001 October 16. doi: 10.1073/pnas.231476498.
PMCID: PMC60139
Plant defense in the absence of jasmonic acid: The role of cyclopentenones
Annick Stintzi, Hans Weber, Philippe Reymond, John Browse, and Edward E. Farmer
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12837–12842. Published online 2001 October 9. doi: 10.1073/pnas.211311098.
PMCID: PMC60140
RALF, a 5-kDa ubiquitous polypeptide in plants, arrests root growth and development
Gregory Pearce, Daniel S. Moura, Johannes Stratmann, and Clarence A. Ryan, Jr.
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12843–12847. Published online 2001 October 2. doi: 10.1073/pnas.201416998.
PMCID: PMC60141
Social Sciences
Anthropology
From the Cover:
Long-term changes in Serengeti-Mara wildebeest and land cover: Pastoralism, population, or policies?
K. Homewood, E. F. Lambin, E. Coast, A. Kariuki, I. Kikula, J. Kivelia, M. Said, S. Serneels, and M. Thompson
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12544–12549. doi: 10.1073/pnas.221053998.
PMCID: PMC60090
Economic Sciences
On the impossibility of predicting the behavior of rational agents
Dean P. Foster and H. Peyton Young
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12848–12853. doi: 10.1073/pnas.211534898.
PMCID: PMC60142
Psychology
When zero is not zero: The problem of ambiguous baseline conditions in fMRI
Craig E. L. Stark and Larry R. Squire
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12760–12766. Published online 2001 October 9. doi: 10.1073/pnas.221462998.
PMCID: PMC60127
Correction
Correction
Proc Natl Acad Sci U S A. 2001 October 23; 98(22): 12854. Published online 2001 October 16.
PMCID: PMC60143
Corrects: Yuichi Hashimoto, et al. A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Aβ. Proc Natl Acad Sci U S A. 2001 May 22; 98(11): 6336–6341.
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