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Volume 104(50);  December 11, 2007
Inaugural Article
The process of mRNA–tRNA translocation
Joachim Frank, Haixiao Gao, Jayati Sengupta, Ning Gao, and Derek J. Taylor
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19671–19678. Published online 2007 November 14. doi: 10.1073/pnas.0708517104.
PMCID: PMC2148355
This Week in PNAS
In This Issue
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19657–19658. doi: 10.1073/iti5007104.
PMCID: PMC2148349
Commentaries
Microscopic evidence for the domestication and spread of maize
Vaughn M. Bryant, Jr.
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19659–19660. Published online 2007 December 4. doi: 10.1073/pnas.0710327105.
PMCID: PMC2148350
New apes fill the gap
Raymond L. Bernor
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19661–19662. Published online 2007 December 5. doi: 10.1073/pnas.0710109105.
PMCID: PMC2148351
Neuro-anatomic evidence for the maturational delay hypothesis of ADHD
Katya Rubia
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19663–19664. Published online 2007 December 6. doi: 10.1073/pnas.0710329105.
PMCID: PMC2148352
Profiles
Profile of Steven Henikoff
Beth Azar
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19665–19667. Published online 2007 December 6. doi: 10.1073/pnas.0710322104.
PMCID: PMC2148353
Profile of Joachim Frank
Kaspar Mossman
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19668–19670. Published online 2007 December 4. doi: 10.1073/pnas.0710323105.
PMCID: PMC2148354
Climate Change and Food Security Special Feature
Research Articles
The impact of climate change on smallholder and subsistence agriculture
John F. Morton
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19680–19685. Published online 2007 December 6. doi: 10.1073/pnas.0701855104.
PMCID: PMC2148357
Crop and pasture response to climate change
Francesco N. Tubiello, Jean-François Soussana, and S. Mark Howden
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19686–19690. Published online 2007 December 6. doi: 10.1073/pnas.0701728104.
PMCID: PMC2148358
Adapting agriculture to climate change
S. Mark Howden, Jean-François Soussana, Francesco N. Tubiello, Netra Chhetri, Michael Dunlop, and Holger Meinke
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19691–19696. Published online 2007 December 6. doi: 10.1073/pnas.0701890104.
PMCID: PMC2148359
Climate change impacts on forestry
Andrei P. Kirilenko and Roger A. Sedjo
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19697–19702. Published online 2007 December 6. doi: 10.1073/pnas.0701424104.
PMCID: PMC2148360
Global food security under climate change
Josef Schmidhuber and Francesco N. Tubiello
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19703–19708. Published online 2007 December 6. doi: 10.1073/pnas.0701976104.
PMCID: PMC2148361
Global fish production and climate change
K. M. Brander
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19709–19714. Published online 2007 December 6. doi: 10.1073/pnas.0702059104.
PMCID: PMC2148362
Perspective
From the Cover: Climate Change and Food Security Special Feature:
Climate change and the adequacy of food and timber in the 21st century
William E. Easterling
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19679. Published online 2007 December 6. doi: 10.1073/pnas.0710388104.
PMCID: PMC2148356
Physical Sciences
Chemistry
Adiabatic operation of a molecular machine
R. Dean Astumian
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19715–19718. Published online 2007 December 5. doi: 10.1073/pnas.0708040104.
PMCID: PMC2148363
Engineering
Circuit theory predicts gene flow in plant and animal populations
Brad H. McRae and Paul Beier
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19885–19890. Published online 2007 December 3. doi: 10.1073/pnas.0706568104.
PMCID: PMC2148392
Environmental Sciences
Changes in severe thunderstorm environment frequency during the 21st century caused by anthropogenically enhanced global radiative forcing
Robert J. Trapp, Noah S. Diffenbaugh, Harold E. Brooks, Michael E. Baldwin, Eric D. Robinson, and Jeremy S. Pal
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19719–19723. Published online 2007 December 4. doi: 10.1073/pnas.0705494104.
PMCID: PMC2148364
Geology
Perennial stream discharge in the hyperarid Atacama Desert of northern Chile during the latest Pleistocene
Peter L. Nester, Eugenia Gayó, Claudio Latorre, Teresa E. Jordan, and Nicolás Blanco
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19724–19729. Published online 2007 December 3. doi: 10.1073/pnas.0705373104.
PMCID: PMC2148365
Geophysics
Observational evidence for volcanic impact on sea level and the global water cycle
A. Grinsted, J. C. Moore, and S. Jevrejeva
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19730–19734. Published online 2007 December 3. doi: 10.1073/pnas.0705825104.
PMCID: PMC2148366
Mathematics
The heat kernel as the pagerank of a graph
Fan Chung
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19735–19740. Published online 2007 December 5. doi: 10.1073/pnas.0708838104.
PMCID: PMC2148367
Statistics
Scaling and efficiency determine the irreversible evolution of a market
F. Baldovin and A. L. Stella
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19741–19744. Published online 2007 December 5. doi: 10.1073/pnas.0706046104.
PMCID: PMC2148368
Biological Sciences
Agricultural Sciences
The impact of climate change on smallholder and subsistence agriculture
John F. Morton
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19680–19685. Published online 2007 December 6. doi: 10.1073/pnas.0701855104.
PMCID: PMC2148357
Crop and pasture response to climate change
Francesco N. Tubiello, Jean-François Soussana, and S. Mark Howden
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19686–19690. Published online 2007 December 6. doi: 10.1073/pnas.0701728104.
PMCID: PMC2148358
Adapting agriculture to climate change
S. Mark Howden, Jean-François Soussana, Francesco N. Tubiello, Netra Chhetri, Michael Dunlop, and Holger Meinke
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19691–19696. Published online 2007 December 6. doi: 10.1073/pnas.0701890104.
PMCID: PMC2148359
Anthropology
From the Cover:
Other-regarding preferences in a non-human primate: Common marmosets provision food altruistically
Judith M. Burkart, Ernst Fehr, Charles Efferson, and Carel P. van Schaik
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19762–19766. Published online 2007 December 5. doi: 10.1073/pnas.0710310104.
PMCID: PMC2148372
Biochemistry
Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases
Xiao Yu, Jin-Peng Sun, Yantao He, Xiaoling Guo, Sijiu Liu, Bo Zhou, Andy Hudmon, and Zhong-Yin Zhang
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19767–19772. Published online 2007 December 3. doi: 10.1073/pnas.0706233104.
PMCID: PMC2148373
Hyperpolarized 13C allows a direct measure of flux through a single enzyme-catalyzed step by NMR
Matthew E. Merritt, Crystal Harrison, Charles Storey, F. Mark Jeffrey, A. Dean Sherry, and Craig R. Malloy
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19773–19777. Published online 2007 December 3. doi: 10.1073/pnas.0706235104.
PMCID: PMC2148374
Monomeric myosin V uses two binding regions for the assembly of stable translocation complexes
Alexander Heuck, Tung-Gia Du, Stephan Jellbauer, Klaus Richter, Claudia Kruse, Sigrun Jaklin, Marisa Müller, Johannes Buchner, Ralf-Peter Jansen, and Dierk Niessing
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19778–19783. Published online 2007 December 4. doi: 10.1073/pnas.0706780104.
PMCID: PMC2148375
Structural insight into distinct mechanisms of protease inhibition by antibodies
Yan Wu, Charles Eigenbrot, Wei-Ching Liang, Scott Stawicki, Steven Shia, Bin Fan, Rajkumar Ganesan, Michael T. Lipari, and Daniel Kirchhofer
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19784–19789. Published online 2007 December 5. doi: 10.1073/pnas.0708251104.
PMCID: PMC2148376
Real-time observation of bacteriophage T4 gp41 helicase reveals an unwinding mechanism
Timothée Lionnet, Michelle M. Spiering, Stephen J. Benkovic, David Bensimon, and Vincent Croquette
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19790–19795. Published online 2007 December 5. doi: 10.1073/pnas.0709793104.
PMCID: PMC2148377
Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17
Ci-Di Chen, Sonia Podvin, Earl Gillespie, Susan E. Leeman, and Carmela R. Abraham
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19796–19801. Published online 2007 December 3. doi: 10.1073/pnas.0709805104.
PMCID: PMC2148378
Structural basis for reduced FGFR2 activity in LADD syndrome: Implications for FGFR autoinhibition and activation
Erin D. Lew, Jae Hyun Bae, Edyta Rohmann, Bernd Wollnik, and Joseph Schlessinger
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19802–19807. Published online 2007 December 3. doi: 10.1073/pnas.0709905104.
PMCID: PMC2148379
Biophysics
The process of mRNA–tRNA translocation
Joachim Frank, Haixiao Gao, Jayati Sengupta, Ning Gao, and Derek J. Taylor
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19671–19678. Published online 2007 November 14. doi: 10.1073/pnas.0708517104.
PMCID: PMC2148355
Metabotyping of Caenorhabditis elegans reveals latent phenotypes
Benjamin J. Blaise, Jean Giacomotto, Bénédicte Elena, Marc-Emmanuel Dumas, Pierre Toulhoat, Laurent Ségalat, and Lyndon Emsley
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19808–19812. Published online 2007 December 5. doi: 10.1073/pnas.0707393104.
PMCID: PMC2148380
Principles underlying energetic coupling along an allosteric communication trajectory of a voltage-activated K+ channel
Evgeniya Sadovsky and Ofer Yifrach
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19813–19818. Published online 2007 December 5. doi: 10.1073/pnas.0708120104.
PMCID: PMC2148381
Localizing frustration in native proteins and protein assemblies
Diego U. Ferreiro, Joseph A. Hegler, Elizabeth A. Komives, and Peter G. Wolynes
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19819–19824. Published online 2007 December 5. doi: 10.1073/pnas.0709915104.
PMCID: PMC2148382
Consequences of localized frustration for the folding mechanism of the IM7 protein
Ludovico Sutto, Joachim Lätzer, Joseph A. Hegler, Diego U. Ferreiro, and Peter G. Wolynes
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19825–19830. Published online 2007 December 5. doi: 10.1073/pnas.0709922104.
PMCID: PMC2148258
How processing of aspartylphosphate is coupled to lumenal gating of the ion pathway in the calcium pump
Chikashi Toyoshima, Yoshiyuki Norimatsu, Shiho Iwasawa, Takeo Tsuda, and Haruo Ogawa
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19831–19836. Published online 2007 December 5. doi: 10.1073/pnas.0709978104.
PMCID: PMC2148383
Cell Biology
ERK MAP kinase is targeted to RSK2 by the phosphoprotein PEA-15
Hema Vaidyanathan, John Opoku-Ansah, Sandra Pastorino, Hema Renganathan, Michelle L. Matter, and Joe W. Ramos
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19837–19842. Published online 2007 December 6. doi: 10.1073/pnas.0704514104.
PMCID: PMC2148384
A role for the inositol kinase Ipk1 in ciliary beating and length maintenance
Bhaskarjyoti Sarmah, Virginia P. Winfrey, Gary E. Olson, Bruce Appel, and Susan R. Wente
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19843–19848. Published online 2007 December 3. doi: 10.1073/pnas.0706934104.
PMCID: PMC2148385
The interplay between the master transcription factor PU.1 and miR-424 regulates human monocyte/macrophage differentiation
A. Rosa, M. Ballarino, A. Sorrentino, O. Sthandier, F. G. De Angelis, M. Marchioni, B. Masella, A. Guarini, A. Fatica, C. Peschle, and I. Bozzoni
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19849–19854. Published online 2007 December 3. doi: 10.1073/pnas.0706963104.
PMCID: PMC2148386
Profiling of UV-induced ATM/ATR signaling pathways
Matthew P. Stokes, John Rush, Joan MacNeill, Jian Min Ren, Kam Sprott, Julie Nardone, Vicky Yang, Sean A. Beausoleil, Steven P. Gygi, Mark Livingstone, Hui Zhang, Roberto D. Polakiewicz, and Michael J. Comb
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19855–19860. Published online 2007 December 6. doi: 10.1073/pnas.0707579104.
PMCID: PMC2148387
Runx2 deficiency and defective subnuclear targeting bypass senescence to promote immortalization and tumorigenic potential
Sayyed K. Zaidi, Sandhya Pande, Jitesh Pratap, Tripti Gaur, Simina Grigoriu, Syed A. Ali, Janet L. Stein, Jane B. Lian, Andre J. van Wijnen, and Gary S. Stein
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19861–19866. Published online 2007 December 5. doi: 10.1073/pnas.0709650104.
PMCID: PMC2148388
Control of mitotic exit by PP2A regulation of Cdc25C and Cdk1
Craig M. Forester, Jessica Maddox, Justin V. Louis, Jozef Goris, and David M. Virshup
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19867–19872. Published online 2007 December 4. doi: 10.1073/pnas.0709879104.
PMCID: PMC2148389
Developmental Biology
The origin of islet-like cells in Drosophila identifies parallels to the vertebrate endocrine axis
Shu Wang, Natalia Tulina, Daniel L. Carlin, and Eric J. Rulifson
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19873–19878. Published online 2007 December 3. doi: 10.1073/pnas.0707465104.
PMCID: PMC2148390
Sonic Hedgehog promotes the development of multipotent neural crest progenitors endowed with both mesenchymal and neural potentials
Giordano W. Calloni, Corinne Glavieux-Pardanaud, Nicole M. Le Douarin, and Elisabeth Dupin
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19879–19884. Published online 2007 December 6. doi: 10.1073/pnas.0708806104.
PMCID: PMC2148391
Ecology
Perennial stream discharge in the hyperarid Atacama Desert of northern Chile during the latest Pleistocene
Peter L. Nester, Eugenia Gayó, Claudio Latorre, Teresa E. Jordan, and Nicolás Blanco
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19724–19729. Published online 2007 December 3. doi: 10.1073/pnas.0705373104.
PMCID: PMC2148365
Circuit theory predicts gene flow in plant and animal populations
Brad H. McRae and Paul Beier
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19885–19890. Published online 2007 December 3. doi: 10.1073/pnas.0706568104.
PMCID: PMC2148392
The modularity of pollination networks
Jens M. Olesen, Jordi Bascompte, Yoko L. Dupont, and Pedro Jordano
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19891–19896. Published online 2007 December 4. doi: 10.1073/pnas.0706375104.
PMCID: PMC2148393
Exceptionally well preserved late Quaternary plant and vertebrate fossils from a blue hole on Abaco, The Bahamas
David W. Steadman, Richard Franz, Gary S. Morgan, Nancy A. Albury, Brian Kakuk, Kenneth Broad, Shelley E. Franz, Keith Tinker, Michael P. Pateman, Terry A. Lott, David M. Jarzen, and David L. Dilcher
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19897–19902. Published online 2007 December 5. doi: 10.1073/pnas.0709572104.
PMCID: PMC2148394
Evolution
Rapid diversification and dispersal during periods of global warming by plethodontid salamanders
David R. Vieites, Mi-Sook Min, and David B. Wake
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19903–19907. Published online 2007 December 5. doi: 10.1073/pnas.0705056104.
PMCID: PMC2148395
Nucleomorph genome of Hemiselmis andersenii reveals complete intron loss and compaction as a driver of protein structure and function
Christopher E. Lane, Krystal van den Heuvel, Catherine Kozera, Bruce A. Curtis, Byron J. Parsons, Sharen Bowman, and John M. Archibald
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19908–19913. Published online 2007 December 6. doi: 10.1073/pnas.0707419104.
PMCID: PMC2148396
Competitive release and facilitation of drug-resistant parasites after therapeutic chemotherapy in a rodent malaria model
Andrew R. Wargo, Silvie Huijben, Jacobus C. de Roode, James Shepherd, and Andrew F. Read
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19914–19919. Published online 2007 December 3. doi: 10.1073/pnas.0707766104.
PMCID: PMC2148397
A portrait of copy-number polymorphism in Drosophila melanogaster
Erik B. Dopman and Daniel L. Hartl
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19920–19925. Published online 2007 December 4. doi: 10.1073/pnas.0709888104.
PMCID: PMC2148398
Genetic drift at expanding frontiers promotes gene segregation
Oskar Hallatschek, Pascal Hersen, Sharad Ramanathan, and David R. Nelson
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19926–19930. Published online 2007 December 4. doi: 10.1073/pnas.0710150104.
PMCID: PMC2148399
Genetics
Input–output robustness in simple bacterial signaling systems
Guy Shinar, Ron Milo, María Rodríguez Martínez, and Uri Alon
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19931–19935. Published online 2007 December 6. doi: 10.1073/pnas.0706792104.
PMCID: PMC2148400
Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling
Ultan McDermott, Sreenath V. Sharma, Lori Dowell, Patricia Greninger, Clara Montagut, Jennifer Lamb, Heidi Archibald, Raul Raudales, Angela Tam, Diana Lee, S. Michael Rothenberg, Jeffrey G. Supko, Raffaella Sordella, Lindsey E. Ulkus, A. John Iafrate, Shyamala Maheswaran, Ching Ni Njauw, Hensin Tsao, Lisa Drew, Jeff H. Hanke, Xiao-Jun Ma, Mark G. Erlander, Nathanael S. Gray, Daniel A. Haber, and Jeffrey Settleman
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19936–19941. Published online 2007 December 6. doi: 10.1073/pnas.0707498104.
PMCID: PMC2148401
Runs of homozygosity reveal highly penetrant recessive loci in schizophrenia
Todd Lencz, Christophe Lambert, Pamela DeRosse, Katherine E. Burdick, T. Vance Morgan, John M. Kane, Raju Kucherlapati, and Anil K. Malhotra
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19942–19947. Published online 2007 December 5. doi: 10.1073/pnas.0710021104.
PMCID: PMC2148402
Protein characterization of Saccharomyces cerevisiae RNA polymerase II after in vivo cross-linking
Daniel F. Tardiff, Katharine C. Abruzzi, and Michael Rosbash
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19948–19953. Published online 2007 December 5. doi: 10.1073/pnas.0710179104.
PMCID: PMC2148403
Immunology
Allograft rejection mediated by memory T cells is resistant to regulation
Jaeseok Yang, Matthew O. Brook, Manuela Carvalho-Gaspar, Jidong Zhang, Hilda E. Ramon, Mohamed H. Sayegh, Kathryn J. Wood, Laurence A. Turka, and Nick D. Jones
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19954–19959. Published online 2007 November 27. doi: 10.1073/pnas.0704397104.
PMCID: PMC2148404
Dramatic increase in naïve T cell turnover is linked to loss of naïve T cells from old primates
Luka Čičin-Šain, Ilhem Messaoudi, Byung Park, Noreen Currier, Shannon Planer, Miranda Fischer, Shane Tackitt, Dragana Nikolich-Žugich, Alfred Legasse, Michael K. Axthelm, Louis J. Picker, Motomi Mori, and Janko Nikolich-Žugich
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19960–19965. Published online 2007 December 4. doi: 10.1073/pnas.0705905104.
PMCID: PMC2148405
Protective effect of noninherited maternal HLA-DR antigens on rheumatoid arthritis development
Anouk L. Feitsma, Jane Worthington, Annette H. M. van der Helm-van Mil, Darren Plant, Wendy Thomson, Jennie Ursum, Dirkjan van Schaardenburg, Irene E. van der Horst-Bruinsma, Jon J. van Rood, Tom W. J. Huizinga, René E. M. Toes, and René R. P. de Vries
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19966–19970. Published online 2007 December 6. doi: 10.1073/pnas.0710260104.
PMCID: PMC2148406
Medical Sciences
MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia
Shuangli Mi, Jun Lu, Miao Sun, Zejuan Li, Hao Zhang, Mary Beth Neilly, Yungui Wang, Zhijian Qian, Jie Jin, Yanming Zhang, Stefan K. Bohlander, Michelle M. Le Beau, Richard A. Larson, Todd R. Golub, Janet D. Rowley, and Jianjun Chen
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19971–19976. Published online 2007 December 4. doi: 10.1073/pnas.0709313104.
PMCID: PMC2148407
Mast cells are an essential hematopoietic component for polyp development
Elias Gounaris, Susan E. Erdman, Clifford Restaino, Michael F. Gurish, Daniel S. Friend, Fotini Gounari, David M. Lee, Guoying Zhang, Jonathan N. Glickman, Kichul Shin, Varada P. Rao, Theofilos Poutahidis, Ralph Weissleder, Kelly M. McNagny, and Khashayarsha Khazaie
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19977–19982. Published online 2007 December 6. doi: 10.1073/pnas.0704620104.
PMCID: PMC2148408
An androgen-regulated miRNA suppresses Bak1 expression and induces androgen-independent growth of prostate cancer cells
Xu-Bao Shi, Lingru Xue, Joy Yang, Ai-Hong Ma, Jianjun Zhao, Ma Xu, Clifford G. Tepper, Christopher P. Evans, Hsing-Jien Kung, and Ralph W. deVere White
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19983–19988. Published online 2007 December 3. doi: 10.1073/pnas.0706641104.
PMCID: PMC2148409
Signal sequence mutation in autosomal dominant form of hypoparathyroidism induces apoptosis that is corrected by a chemical chaperone
Rupak Datta, Abdul Waheed, Gul N. Shah, and William S. Sly
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19989–19994. Published online 2007 December 3. doi: 10.1073/pnas.0708725104.
PMCID: PMC2148410
In vitamin B12 deficiency, higher serum folate is associated with increased total homocysteine and methylmalonic acid concentrations
Jacob Selhub, Martha Savaria Morris, and Paul F. Jacques
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19995–20000. Published online 2007 December 4. doi: 10.1073/pnas.0709487104.
PMCID: PMC2148411
Effects of rearrangement and allelic exclusion of JJAZ1/SUZ12 on cell proliferation and survival
Hui Li, XianYong Ma, Jinglan Wang, Jason Koontz, Marisa Nucci, and Jeffrey Sklar
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20001–20006. Published online 2007 December 6. doi: 10.1073/pnas.0709986104.
PMCID: PMC2148412
Assessing the significance of chromosomal aberrations in cancer: Methodology and application to glioma
Rameen Beroukhim, Gad Getz, Leia Nghiemphu, Jordi Barretina, Teli Hsueh, David Linhart, Igor Vivanco, Jeffrey C. Lee, Julie H. Huang, Sethu Alexander, Jinyan Du, Tweeny Kau, Roman K. Thomas, Kinjal Shah, Horacio Soto, Sven Perner, John Prensner, Ralph M. Debiasi, Francesca Demichelis, Charlie Hatton, Mark A. Rubin, Levi A. Garraway, Stan F. Nelson, Linda Liau, Paul S. Mischel, Tim F. Cloughesy, Matthew Meyerson, Todd A. Golub, Eric S. Lander, Ingo K. Mellinghoff, and William R. Sellers
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20007–20012. Published online 2007 December 6. doi: 10.1073/pnas.0710052104.
PMCID: PMC2148413
The preleukemic state of mice reconstituted with Mixl1-transduced marrow cells
Donald Metcalf, Stefan Glaser, Sandra Mifsud, Ladina Di Rago, and Lorraine Robb
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20013–20018. Published online 2007 December 3. doi: 10.1073/pnas.0710339104.
PMCID: PMC2148414
Microbiology
Recruitment of conjugative DNA transfer substrate to Agrobacterium type IV secretion apparatus
Minliang Guo, Shouguang Jin, Deying Sun, Choy L. Hew, and Shen Q. Pan
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20019–20024. Published online 2007 December 3. doi: 10.1073/pnas.0701738104.
PMCID: PMC2148415
A herpesvirus ubiquitin-specific protease is critical for efficient T cell lymphoma formation
Keith Jarosinski, Lisa Kattenhorn, Benedikt Kaufer, Hidde Ploegh, and Nikolaus Osterrieder
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20025–20030. Published online 2007 December 4. doi: 10.1073/pnas.0706295104.
PMCID: PMC2148416
Ubiquitin-dependent virus particle budding without viral protein ubiquitination
Maria Zhadina, Myra O. McClure, Marc C. Johnson, and Paul D. Bieniasz
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20031–20036. Published online 2007 December 3. doi: 10.1073/pnas.0708002104.
PMCID: PMC2148417
Human cytomegalovirus uses two distinct pathways to enter retinal pigmented epithelial cells
Dai Wang, Qian-Chun Yu, Jörg Schröer, Eain Murphy, and Thomas Shenk
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20037–20042. Published online 2007 December 5. doi: 10.1073/pnas.0709704104.
PMCID: PMC2148418
Mononeme: A new secretory organelle in Plasmodium falciparum merozoites identified by localization of rhomboid-1 protease
Subhash Singh, Matthew Plassmeyer, Deepak Gaur, and Louis H. Miller
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20043–20048. Published online 2007 November 28. doi: 10.1073/pnas.0709999104.
PMCID: PMC2148419
Neuroscience
RET signaling does not modulate MPTP toxicity but is required for regeneration of dopaminergic axon terminals
Sebastian Kowsky, Charlotte Pöppelmeyer, Edgar R. Kramer, Björn H. Falkenburger, Anja Kruse, Rüdiger Klein, and Jörg B. Schulz
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20049–20054. Published online 2007 December 4. doi: 10.1073/pnas.0706177104.
PMCID: PMC2148420
Trafficking-dependent phosphorylation of Kv1.2 regulates voltage-gated potassium channel cell surface expression
Jae-Won Yang, Helene Vacher, Kang-Sik Park, Eliana Clark, and James S. Trimmer
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20055–20060. Published online 2007 December 3. doi: 10.1073/pnas.0708574104.
PMCID: PMC2148421
From the Cover:
Redirection of cutaneous sensation from the hand to the chest skin of human amputees with targeted reinnervation
Todd A. Kuiken, Paul D. Marasco, Blair A. Lock, R. Norman Harden, and Julius P. A. Dewald
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20061–20066. Published online 2007 November 28. doi: 10.1073/pnas.0706525104.
PMCID: PMC2148422
Deletion of the core-H region in mice abolishes the expression of three proximal odorant receptor genes in cis
Hirofumi Nishizumi, Kouhei Kumasaka, Nobuko Inoue, Ai Nakashima, and Hitoshi Sakano
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20067–20072. Published online 2007 December 5. doi: 10.1073/pnas.0706544105.
PMCID: PMC2148423
Perceptual detection as a dynamical bistability phenomenon: A neurocomputational correlate of sensation
Gustavo Deco, Mar Pérez-Sanagustín, Victor de Lafuente, and Ranulfo Romo
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20073–20077. Published online 2007 December 5. doi: 10.1073/pnas.0709794104.
PMCID: PMC2148424
Two forces for arousal: Pitting hunger versus circadian influences and identifying neurons responsible for changes in behavioral arousal
Ana C. Ribeiro, Evelyn Sawa, Isabelle Carren-LeSauter, Joseph LeSauter, Rae Silver, and Donald W. Pfaff
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20078–20083. Published online 2007 December 3. doi: 10.1073/pnas.0710096104.
PMCID: PMC2148425
Neural correlates of trust
Frank Krueger, Kevin McCabe, Jorge Moll, Nikolaus Kriegeskorte, Roland Zahn, Maren Strenziok, Armin Heinecke, and Jordan Grafman
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20084–20089. Published online 2007 December 4. doi: 10.1073/pnas.0710103104.
PMCID: PMC2148426
Homer1a is a core brain molecular correlate of sleep loss
Stéphanie Maret, Stéphane Dorsaz, Laure Gurcel, Sylvain Pradervand, Brice Petit, Corinne Pfister, Otto Hagenbuchle, Bruce F. O'Hara, Paul Franken, and Mehdi Tafti
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20090–20095. Published online 2007 December 6. doi: 10.1073/pnas.0710131104.
PMCID: PMC2148427
Pharmacology
dsAAV type 2-mediated gene transfer of MORS196A-EGFP into spinal cord as a pain management paradigm
S. L. Chen, H. I. Ma, J. M. Han, P. L. Tao, P. Y. Law, and H. H. Loh
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20096–20101. Published online 2007 December 4. doi: 10.1073/pnas.0703409104.
PMCID: PMC2148428
Physiology
A developmental cycle masks output from the circadian oscillator under conditions of choline deficiency in Neurospora
Mi Shi, Luis F. Larrondo, Jennifer J. Loros, and Jay C. Dunlap
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20102–20107. Published online 2007 December 4. doi: 10.1073/pnas.0706631104.
PMCID: PMC2148429
Loss of skeletal muscle strength by ablation of the sarcoplasmic reticulum protein JP45
Osvaldo Delbono, Jinyu Xia, Susan Treves, Zhong-Min Wang, Ramon Jimenez-Moreno, Anthony M. Payne, María Laura Messi, Alexandre Briguet, Florian Schaerer, Miyuki Nishi, Hiroshi Takeshima, and Francesco Zorzato
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20108–20113. Published online 2007 December 5. doi: 10.1073/pnas.0707389104.
PMCID: PMC2148430
Skeletal muscle resists stretch by rapid binding of the second motor domain of myosin to actin
Elisabetta Brunello, Massimo Reconditi, Ravikrishnan Elangovan, Marco Linari, Yin-Biao Sun, Theyencheri Narayanan, Pierre Panine, Gabriella Piazzesi, Malcolm Irving, and Vincenzo Lombardi
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20114–20119. Published online 2007 December 6. doi: 10.1073/pnas.0707626104.
PMCID: PMC2148431
Phorbol ester stimulation of RasGRP1 regulates the sodium-chloride cotransporter by a PKC-independent pathway
Benjamin Ko, Leena M. Joshi, Leslie L. Cooke, Norma Vazquez, Mark W. Musch, Steven C. Hebert, Gerardo Gamba, and Robert S. Hoover
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20120–20125. Published online 2007 December 5. doi: 10.1073/pnas.0709506104.
PMCID: PMC2148432
Plant Biology
A high-affinity molybdate transporter in eukaryotes
Manuel Tejada-Jiménez, Ángel Llamas, Emanuel Sanz-Luque, Aurora Galván, and Emilio Fernández
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20126–20130. Published online 2007 December 5. doi: 10.1073/pnas.0704646104.
PMCID: PMC2148433
Pseudomonas syringae type III effector AvrRpt2 alters Arabidopsis thaliana auxin physiology
Zhongying Chen, Jennifer L. Agnew, Jerry D. Cohen, Ping He, Libo Shan, Jen Sheen, and Barbara N. Kunkel
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20131–20136. Published online 2007 December 3. doi: 10.1073/pnas.0704901104.
PMCID: PMC2148434
Psychology
Anterior temporal lobes mediate semantic representation: Mimicking semantic dementia by using rTMS in normal participants
Gorana Pobric, Elizabeth Jefferies, and Matthew A. Lambon Ralph
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20137–20141. Published online 2007 December 3. doi: 10.1073/pnas.0707383104.
PMCID: PMC2148435
Sustainability Science
The impact of climate change on smallholder and subsistence agriculture
John F. Morton
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19680–19685. Published online 2007 December 6. doi: 10.1073/pnas.0701855104.
PMCID: PMC2148357
Crop and pasture response to climate change
Francesco N. Tubiello, Jean-François Soussana, and S. Mark Howden
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19686–19690. Published online 2007 December 6. doi: 10.1073/pnas.0701728104.
PMCID: PMC2148358
Adapting agriculture to climate change
S. Mark Howden, Jean-François Soussana, Francesco N. Tubiello, Netra Chhetri, Michael Dunlop, and Holger Meinke
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19691–19696. Published online 2007 December 6. doi: 10.1073/pnas.0701890104.
PMCID: PMC2148359
Climate change impacts on forestry
Andrei P. Kirilenko and Roger A. Sedjo
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19697–19702. Published online 2007 December 6. doi: 10.1073/pnas.0701424104.
PMCID: PMC2148360
Global food security under climate change
Josef Schmidhuber and Francesco N. Tubiello
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19703–19708. Published online 2007 December 6. doi: 10.1073/pnas.0701976104.
PMCID: PMC2148361
Global fish production and climate change
K. M. Brander
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19709–19714. Published online 2007 December 6. doi: 10.1073/pnas.0702059104.
PMCID: PMC2148362
Social Sciences
Anthropology
From the Cover:
Ancient jades map 3,000 years of prehistoric exchange in Southeast Asia
Hsiao-Chun Hung, Yoshiyuki Iizuka, Peter Bellwood, Kim Dung Nguyen, Bérénice Bellina, Praon Silapanth, Eusebio Dizon, Rey Santiago, Ipoi Datan, and Jonathan H. Manton
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19745–19750. Published online 2007 November 29. doi: 10.1073/pnas.0707304104.
PMCID: PMC2148369
Economic Sciences
Scaling and efficiency determine the irreversible evolution of a market
F. Baldovin and A. L. Stella
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19741–19744. Published online 2007 December 5. doi: 10.1073/pnas.0706046104.
PMCID: PMC2148368
Psychology
The hidden structure of overimitation
Derek E. Lyons, Andrew G. Young, and Frank C. Keil
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19751–19756. Published online 2007 December 4. doi: 10.1073/pnas.0704452104.
PMCID: PMC2148370
Subliminal exposure to national flags affects political thought and behavior
Ran R. Hassin, Melissa J. Ferguson, Daniella Shidlovski, and Tamar Gross
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19757–19761. Published online 2007 December 4. doi: 10.1073/pnas.0704679104.
PMCID: PMC2148371
Social Sciences
The impact of climate change on smallholder and subsistence agriculture
John F. Morton
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19680–19685. Published online 2007 December 6. doi: 10.1073/pnas.0701855104.
PMCID: PMC2148357
From the Cover:
Other-regarding preferences in a non-human primate: Common marmosets provision food altruistically
Judith M. Burkart, Ernst Fehr, Charles Efferson, and Carel P. van Schaik
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19762–19766. Published online 2007 December 5. doi: 10.1073/pnas.0710310104.
PMCID: PMC2148372
Corrections
Correction for This Week in PNAS
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20142. doi: 10.1073/pnas.0710562104.
PMCID: PMC2148436
Corrects: In This Issue. Proc Natl Acad Sci U S A. 2007 October 16; 104(42): 16391–16392.
Correction for Lewis and Nocera, Powering the planet: Chemical challenges in solar energy utilization
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20142. doi: 10.1073/pnas.0710683104.
PMCID: PMC2148437
Corrects: Nathan S. Lewis, et al. Powering the planet: Chemical challenges in solar energy utilization. Proc Natl Acad Sci U S A. 2006 October 24; 103(43): 15729–15735.
Correction for Panfilov et al., Drift and breakup of spiral waves in reaction–diffusion–mechanics systems
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20142. doi: 10.1073/pnas.0710559104.
PMCID: PMC2148438
Corrects: A. V. Panfilov, et al. Drift and breakup of spiral waves in reaction–diffusion–mechanics systems. Proc Natl Acad Sci U S A. 2007 May 8; 104(19): 7922–7926.
Correction for Lim and Kai, Unique germ-line organelle, nuage, functions to repress selfish genetic elements in Drosophila melanogaster
Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20143. Published online 2007 November 15. doi: 10.1073/pnas.0710102104.
PMCID: PMC2148439
Corrects: Ai Khim Lim, et al. Unique germ-line organelle, nuage, functions to repress selfish genetic elements in Drosophila melanogaster. Proc Natl Acad Sci U S A. 2007 April 17; 104(16): 6714–6719.
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