| | This journal provides immediate access to some articles. Inaugural Article INAUGURAL ARTICLE by a Recently Elected Academy Member: The process of mRNA–tRNA translocation Joachim Frank, Haixiao Gao, Jayati Sengupta, Ning Gao, and Derek J. Taylor Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19671–19678. Published online 2007 November 14. doi: 10.1073/pnas.0708517104.PMCID: PMC2148355 This Week in PNAS Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19657–19658. doi: 10.1073/iti5007104.PMCID: PMC2148349 Commentaries Microscopic evidence for the domestication and spread of maize Vaughn M. Bryant, Jr. Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19659–19660. Published online 2007 December 4. doi: 10.1073/pnas.0710327105.PMCID: PMC2148350 New apes fill the gap Raymond L. Bernor Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19661–19662. Published online 2007 December 5. doi: 10.1073/pnas.0710109105.PMCID: PMC2148351 Neuro-anatomic evidence for the maturational delay hypothesis of ADHD Katya Rubia Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19663–19664. Published online 2007 December 6. doi: 10.1073/pnas.0710329105.PMCID: PMC2148352 Profiles Profile of Steven Henikoff Beth Azar Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19665–19667. Published online 2007 December 6. doi: 10.1073/pnas.0710322104.PMCID: PMC2148353 Profile of Joachim Frank Kaspar Mossman Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19668–19670. Published online 2007 December 4. doi: 10.1073/pnas.0710323105.PMCID: PMC2148354 Climate Change and Food Security Special Feature Research Articles The impact of climate change on smallholder and subsistence agriculture John F. Morton Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19680–19685. Published online 2007 December 6. doi: 10.1073/pnas.0701855104.PMCID: PMC2148357 Crop and pasture response to climate change Francesco N. Tubiello, Jean-François Soussana, and S. Mark Howden Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19686–19690. Published online 2007 December 6. doi: 10.1073/pnas.0701728104.PMCID: PMC2148358 Adapting agriculture to climate change S. Mark Howden, Jean-François Soussana, Francesco N. Tubiello, Netra Chhetri, Michael Dunlop, and Holger Meinke Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19691–19696. Published online 2007 December 6. doi: 10.1073/pnas.0701890104.PMCID: PMC2148359 Climate change impacts on forestry Andrei P. Kirilenko and Roger A. Sedjo Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19697–19702. Published online 2007 December 6. doi: 10.1073/pnas.0701424104.PMCID: PMC2148360 Global food security under climate change Josef Schmidhuber and Francesco N. Tubiello Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19703–19708. Published online 2007 December 6. doi: 10.1073/pnas.0701976104.PMCID: PMC2148361 Global fish production and climate change K. M. Brander Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19709–19714. Published online 2007 December 6. doi: 10.1073/pnas.0702059104.PMCID: PMC2148362 Perspective From the Cover: Climate Change and Food Security Special Feature: Climate change and the adequacy of food and timber in the 21st century William E. Easterling Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19679. Published online 2007 December 6. doi: 10.1073/pnas.0710388104.PMCID: PMC2148356 Physical Sciences Chemistry Adiabatic operation of a molecular machine R. Dean Astumian Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19715–19718. Published online 2007 December 5. doi: 10.1073/pnas.0708040104.PMCID: PMC2148363 Engineering Circuit theory predicts gene flow in plant and animal populations Brad H. McRae and Paul Beier Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19885–19890. Published online 2007 December 3. doi: 10.1073/pnas.0706568104.PMCID: PMC2148392 Environmental Sciences Changes in severe thunderstorm environment frequency during the 21st century caused by anthropogenically enhanced global radiative forcing Robert J. Trapp, Noah S. Diffenbaugh, Harold E. Brooks, Michael E. Baldwin, Eric D. Robinson, and Jeremy S. Pal Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19719–19723. Published online 2007 December 4. doi: 10.1073/pnas.0705494104.PMCID: PMC2148364 Geology Perennial stream discharge in the hyperarid Atacama Desert of northern Chile during the latest Pleistocene Peter L. Nester, Eugenia Gayó, Claudio Latorre, Teresa E. Jordan, and Nicolás Blanco Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19724–19729. Published online 2007 December 3. doi: 10.1073/pnas.0705373104.PMCID: PMC2148365 Geophysics Observational evidence for volcanic impact on sea level and the global water cycle A. Grinsted, J. C. Moore, and S. Jevrejeva Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19730–19734. Published online 2007 December 3. doi: 10.1073/pnas.0705825104.PMCID: PMC2148366 Mathematics The heat kernel as the pagerank of a graph Fan Chung Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19735–19740. Published online 2007 December 5. doi: 10.1073/pnas.0708838104.PMCID: PMC2148367 Statistics Scaling and efficiency determine the irreversible evolution of a market F. Baldovin and A. L. Stella Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19741–19744. Published online 2007 December 5. doi: 10.1073/pnas.0706046104.PMCID: PMC2148368 Biological Sciences Agricultural Sciences The impact of climate change on smallholder and subsistence agriculture John F. Morton Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19680–19685. Published online 2007 December 6. doi: 10.1073/pnas.0701855104.PMCID: PMC2148357 Crop and pasture response to climate change Francesco N. Tubiello, Jean-François Soussana, and S. Mark Howden Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19686–19690. Published online 2007 December 6. doi: 10.1073/pnas.0701728104.PMCID: PMC2148358 Adapting agriculture to climate change S. Mark Howden, Jean-François Soussana, Francesco N. Tubiello, Netra Chhetri, Michael Dunlop, and Holger Meinke Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19691–19696. Published online 2007 December 6. doi: 10.1073/pnas.0701890104.PMCID: PMC2148359 Anthropology From the Cover: Other-regarding preferences in a non-human primate: Common marmosets provision food altruistically Judith M. Burkart, Ernst Fehr, Charles Efferson, and Carel P. van Schaik Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19762–19766. Published online 2007 December 5. doi: 10.1073/pnas.0710310104.PMCID: PMC2148372 Biochemistry Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases Xiao Yu, Jin-Peng Sun, Yantao He, Xiaoling Guo, Sijiu Liu, Bo Zhou, Andy Hudmon, and Zhong-Yin Zhang Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19767–19772. Published online 2007 December 3. doi: 10.1073/pnas.0706233104.PMCID: PMC2148373 Hyperpolarized 13C allows a direct measure of flux through a single enzyme-catalyzed step by NMR Matthew E. Merritt, Crystal Harrison, Charles Storey, F. Mark Jeffrey, A. Dean Sherry, and Craig R. Malloy Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19773–19777. Published online 2007 December 3. doi: 10.1073/pnas.0706235104.PMCID: PMC2148374 Monomeric myosin V uses two binding regions for the assembly of stable translocation complexes Alexander Heuck, Tung-Gia Du, Stephan Jellbauer, Klaus Richter, Claudia Kruse, Sigrun Jaklin, Marisa Müller, Johannes Buchner, Ralf-Peter Jansen, and Dierk Niessing Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19778–19783. Published online 2007 December 4. doi: 10.1073/pnas.0706780104.PMCID: PMC2148375 Structural insight into distinct mechanisms of protease inhibition by antibodies Yan Wu, Charles Eigenbrot, Wei-Ching Liang, Scott Stawicki, Steven Shia, Bin Fan, Rajkumar Ganesan, Michael T. Lipari, and Daniel Kirchhofer Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19784–19789. Published online 2007 December 5. doi: 10.1073/pnas.0708251104.PMCID: PMC2148376 Real-time observation of bacteriophage T4 gp41 helicase reveals an unwinding mechanism Timothée Lionnet, Michelle M. Spiering, Stephen J. Benkovic, David Bensimon, and Vincent Croquette Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19790–19795. Published online 2007 December 5. doi: 10.1073/pnas.0709793104.PMCID: PMC2148377 Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17 Ci-Di Chen, Sonia Podvin, Earl Gillespie, Susan E. Leeman, and Carmela R. Abraham Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19796–19801. Published online 2007 December 3. doi: 10.1073/pnas.0709805104.PMCID: PMC2148378 Structural basis for reduced FGFR2 activity in LADD syndrome: Implications for FGFR autoinhibition and activation Erin D. Lew, Jae Hyun Bae, Edyta Rohmann, Bernd Wollnik, and Joseph Schlessinger Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19802–19807. Published online 2007 December 3. doi: 10.1073/pnas.0709905104.PMCID: PMC2148379 Biophysics INAUGURAL ARTICLE by a Recently Elected Academy Member: The process of mRNA–tRNA translocation Joachim Frank, Haixiao Gao, Jayati Sengupta, Ning Gao, and Derek J. Taylor Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19671–19678. Published online 2007 November 14. doi: 10.1073/pnas.0708517104.PMCID: PMC2148355 Metabotyping of Caenorhabditis elegans reveals latent phenotypes Benjamin J. Blaise, Jean Giacomotto, Bénédicte Elena, Marc-Emmanuel Dumas, Pierre Toulhoat, Laurent Ségalat, and Lyndon Emsley Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19808–19812. Published online 2007 December 5. doi: 10.1073/pnas.0707393104.PMCID: PMC2148380 Principles underlying energetic coupling along an allosteric communication trajectory of a voltage-activated K+ channel Evgeniya Sadovsky and Ofer Yifrach Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19813–19818. Published online 2007 December 5. doi: 10.1073/pnas.0708120104.PMCID: PMC2148381 Localizing frustration in native proteins and protein assemblies Diego U. Ferreiro, Joseph A. Hegler, Elizabeth A. Komives, and Peter G. Wolynes Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19819–19824. Published online 2007 December 5. doi: 10.1073/pnas.0709915104.PMCID: PMC2148382 Consequences of localized frustration for the folding mechanism of the IM7 protein Ludovico Sutto, Joachim Lätzer, Joseph A. Hegler, Diego U. Ferreiro, and Peter G. Wolynes Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19825–19830. Published online 2007 December 5. doi: 10.1073/pnas.0709922104.PMCID: PMC2148258 How processing of aspartylphosphate is coupled to lumenal gating of the ion pathway in the calcium pump Chikashi Toyoshima, Yoshiyuki Norimatsu, Shiho Iwasawa, Takeo Tsuda, and Haruo Ogawa Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19831–19836. Published online 2007 December 5. doi: 10.1073/pnas.0709978104.PMCID: PMC2148383 Cell Biology ERK MAP kinase is targeted to RSK2 by the phosphoprotein PEA-15 Hema Vaidyanathan, John Opoku-Ansah, Sandra Pastorino, Hema Renganathan, Michelle L. Matter, and Joe W. Ramos Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19837–19842. Published online 2007 December 6. doi: 10.1073/pnas.0704514104.PMCID: PMC2148384 A role for the inositol kinase Ipk1 in ciliary beating and length maintenance Bhaskarjyoti Sarmah, Virginia P. Winfrey, Gary E. Olson, Bruce Appel, and Susan R. Wente Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19843–19848. Published online 2007 December 3. doi: 10.1073/pnas.0706934104.PMCID: PMC2148385 The interplay between the master transcription factor PU.1 and miR-424 regulates human monocyte/macrophage differentiation A. Rosa, M. Ballarino, A. Sorrentino, O. Sthandier, F. G. De Angelis, M. Marchioni, B. Masella, A. Guarini, A. Fatica, C. Peschle, and I. Bozzoni Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19849–19854. Published online 2007 December 3. doi: 10.1073/pnas.0706963104.PMCID: PMC2148386 Profiling of UV-induced ATM/ATR signaling pathways Matthew P. Stokes, John Rush, Joan MacNeill, Jian Min Ren, Kam Sprott, Julie Nardone, Vicky Yang, Sean A. Beausoleil, Steven P. Gygi, Mark Livingstone, Hui Zhang, Roberto D. Polakiewicz, and Michael J. Comb Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19855–19860. Published online 2007 December 6. doi: 10.1073/pnas.0707579104.PMCID: PMC2148387 Runx2 deficiency and defective subnuclear targeting bypass senescence to promote immortalization and tumorigenic potential Sayyed K. Zaidi, Sandhya Pande, Jitesh Pratap, Tripti Gaur, Simina Grigoriu, Syed A. Ali, Janet L. Stein, Jane B. Lian, Andre J. van Wijnen, and Gary S. Stein Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19861–19866. Published online 2007 December 5. doi: 10.1073/pnas.0709650104.PMCID: PMC2148388 Control of mitotic exit by PP2A regulation of Cdc25C and Cdk1 Craig M. Forester, Jessica Maddox, Justin V. Louis, Jozef Goris, and David M. Virshup Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19867–19872. Published online 2007 December 4. doi: 10.1073/pnas.0709879104.PMCID: PMC2148389 Developmental Biology The origin of islet-like cells in Drosophila identifies parallels to the vertebrate endocrine axis Shu Wang, Natalia Tulina, Daniel L. Carlin, and Eric J. Rulifson Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19873–19878. Published online 2007 December 3. doi: 10.1073/pnas.0707465104.PMCID: PMC2148390 Sonic Hedgehog promotes the development of multipotent neural crest progenitors endowed with both mesenchymal and neural potentials Giordano W. Calloni, Corinne Glavieux-Pardanaud, Nicole M. Le Douarin, and Elisabeth Dupin Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19879–19884. Published online 2007 December 6. doi: 10.1073/pnas.0708806104.PMCID: PMC2148391 Ecology Perennial stream discharge in the hyperarid Atacama Desert of northern Chile during the latest Pleistocene Peter L. Nester, Eugenia Gayó, Claudio Latorre, Teresa E. Jordan, and Nicolás Blanco Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19724–19729. Published online 2007 December 3. doi: 10.1073/pnas.0705373104.PMCID: PMC2148365 Circuit theory predicts gene flow in plant and animal populations Brad H. McRae and Paul Beier Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19885–19890. Published online 2007 December 3. doi: 10.1073/pnas.0706568104.PMCID: PMC2148392 The modularity of pollination networks Jens M. Olesen, Jordi Bascompte, Yoko L. Dupont, and Pedro Jordano Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19891–19896. Published online 2007 December 4. doi: 10.1073/pnas.0706375104.PMCID: PMC2148393 Exceptionally well preserved late Quaternary plant and vertebrate fossils from a blue hole on Abaco, The Bahamas David W. Steadman, Richard Franz, Gary S. Morgan, Nancy A. Albury, Brian Kakuk, Kenneth Broad, Shelley E. Franz, Keith Tinker, Michael P. Pateman, Terry A. Lott, David M. Jarzen, and David L. Dilcher Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19897–19902. Published online 2007 December 5. doi: 10.1073/pnas.0709572104.PMCID: PMC2148394 Evolution Rapid diversification and dispersal during periods of global warming by plethodontid salamanders David R. Vieites, Mi-Sook Min, and David B. Wake Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19903–19907. Published online 2007 December 5. doi: 10.1073/pnas.0705056104.PMCID: PMC2148395 Nucleomorph genome of Hemiselmis andersenii reveals complete intron loss and compaction as a driver of protein structure and function Christopher E. Lane, Krystal van den Heuvel, Catherine Kozera, Bruce A. Curtis, Byron J. Parsons, Sharen Bowman, and John M. Archibald Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19908–19913. Published online 2007 December 6. doi: 10.1073/pnas.0707419104.PMCID: PMC2148396 Competitive release and facilitation of drug-resistant parasites after therapeutic chemotherapy in a rodent malaria model Andrew R. Wargo, Silvie Huijben, Jacobus C. de Roode, James Shepherd, and Andrew F. Read Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19914–19919. Published online 2007 December 3. doi: 10.1073/pnas.0707766104.PMCID: PMC2148397 A portrait of copy-number polymorphism in Drosophila melanogaster Erik B. Dopman and Daniel L. Hartl Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19920–19925. Published online 2007 December 4. doi: 10.1073/pnas.0709888104.PMCID: PMC2148398 Genetic drift at expanding frontiers promotes gene segregation Oskar Hallatschek, Pascal Hersen, Sharad Ramanathan, and David R. Nelson Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19926–19930. Published online 2007 December 4. doi: 10.1073/pnas.0710150104.PMCID: PMC2148399 Genetics Input–output robustness in simple bacterial signaling systems Guy Shinar, Ron Milo, María Rodríguez Martínez, and Uri Alon Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19931–19935. Published online 2007 December 6. doi: 10.1073/pnas.0706792104.PMCID: PMC2148400 Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling Ultan McDermott, Sreenath V. Sharma, Lori Dowell, Patricia Greninger, Clara Montagut, Jennifer Lamb, Heidi Archibald, Raul Raudales, Angela Tam, Diana Lee, S. Michael Rothenberg, Jeffrey G. Supko, Raffaella Sordella, Lindsey E. Ulkus, A. John Iafrate, Shyamala Maheswaran, Ching Ni Njauw, Hensin Tsao, Lisa Drew, Jeff H. Hanke, Xiao-Jun Ma, Mark G. Erlander, Nathanael S. Gray, Daniel A. Haber, and Jeffrey Settleman Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19936–19941. Published online 2007 December 6. doi: 10.1073/pnas.0707498104.PMCID: PMC2148401 Runs of homozygosity reveal highly penetrant recessive loci in schizophrenia Todd Lencz, Christophe Lambert, Pamela DeRosse, Katherine E. Burdick, T. Vance Morgan, John M. Kane, Raju Kucherlapati, and Anil K. Malhotra Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19942–19947. Published online 2007 December 5. doi: 10.1073/pnas.0710021104.PMCID: PMC2148402 Protein characterization of Saccharomyces cerevisiae RNA polymerase II after in vivo cross-linking Daniel F. Tardiff, Katharine C. Abruzzi, and Michael Rosbash Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19948–19953. Published online 2007 December 5. doi: 10.1073/pnas.0710179104.PMCID: PMC2148403 Immunology Allograft rejection mediated by memory T cells is resistant to regulation Jaeseok Yang, Matthew O. Brook, Manuela Carvalho-Gaspar, Jidong Zhang, Hilda E. Ramon, Mohamed H. Sayegh, Kathryn J. Wood, Laurence A. Turka, and Nick D. Jones Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19954–19959. Published online 2007 November 27. doi: 10.1073/pnas.0704397104.PMCID: PMC2148404 Dramatic increase in naïve T cell turnover is linked to loss of naïve T cells from old primates Luka Čičin-Šain, Ilhem Messaoudi, Byung Park, Noreen Currier, Shannon Planer, Miranda Fischer, Shane Tackitt, Dragana Nikolich-Žugich, Alfred Legasse, Michael K. Axthelm, Louis J. Picker, Motomi Mori, and Janko Nikolich-Žugich Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19960–19965. Published online 2007 December 4. doi: 10.1073/pnas.0705905104.PMCID: PMC2148405 Protective effect of noninherited maternal HLA-DR antigens on rheumatoid arthritis development Anouk L. Feitsma, Jane Worthington, Annette H. M. van der Helm-van Mil, Darren Plant, Wendy Thomson, Jennie Ursum, Dirkjan van Schaardenburg, Irene E. van der Horst-Bruinsma, Jon J. van Rood, Tom W. J. Huizinga, René E. M. Toes, and René R. P. de Vries Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19966–19970. Published online 2007 December 6. doi: 10.1073/pnas.0710260104.PMCID: PMC2148406 Medical Sciences MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia Shuangli Mi, Jun Lu, Miao Sun, Zejuan Li, Hao Zhang, Mary Beth Neilly, Yungui Wang, Zhijian Qian, Jie Jin, Yanming Zhang, Stefan K. Bohlander, Michelle M. Le Beau, Richard A. Larson, Todd R. Golub, Janet D. Rowley, and Jianjun Chen Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19971–19976. Published online 2007 December 4. doi: 10.1073/pnas.0709313104.PMCID: PMC2148407 Mast cells are an essential hematopoietic component for polyp development Elias Gounaris, Susan E. Erdman, Clifford Restaino, Michael F. Gurish, Daniel S. Friend, Fotini Gounari, David M. Lee, Guoying Zhang, Jonathan N. Glickman, Kichul Shin, Varada P. Rao, Theofilos Poutahidis, Ralph Weissleder, Kelly M. McNagny, and Khashayarsha Khazaie Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19977–19982. Published online 2007 December 6. doi: 10.1073/pnas.0704620104.PMCID: PMC2148408 An androgen-regulated miRNA suppresses Bak1 expression and induces androgen-independent growth of prostate cancer cells Xu-Bao Shi, Lingru Xue, Joy Yang, Ai-Hong Ma, Jianjun Zhao, Ma Xu, Clifford G. Tepper, Christopher P. Evans, Hsing-Jien Kung, and Ralph W. deVere White Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19983–19988. Published online 2007 December 3. doi: 10.1073/pnas.0706641104.PMCID: PMC2148409 Signal sequence mutation in autosomal dominant form of hypoparathyroidism induces apoptosis that is corrected by a chemical chaperone Rupak Datta, Abdul Waheed, Gul N. Shah, and William S. Sly Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19989–19994. Published online 2007 December 3. doi: 10.1073/pnas.0708725104.PMCID: PMC2148410 In vitamin B12 deficiency, higher serum folate is associated with increased total homocysteine and methylmalonic acid concentrations Jacob Selhub, Martha Savaria Morris, and Paul F. Jacques Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19995–20000. Published online 2007 December 4. doi: 10.1073/pnas.0709487104.PMCID: PMC2148411 Effects of rearrangement and allelic exclusion of JJAZ1/SUZ12 on cell proliferation and survival Hui Li, XianYong Ma, Jinglan Wang, Jason Koontz, Marisa Nucci, and Jeffrey Sklar Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20001–20006. Published online 2007 December 6. doi: 10.1073/pnas.0709986104.PMCID: PMC2148412 Assessing the significance of chromosomal aberrations in cancer: Methodology and application to glioma Rameen Beroukhim, Gad Getz, Leia Nghiemphu, Jordi Barretina, Teli Hsueh, David Linhart, Igor Vivanco, Jeffrey C. Lee, Julie H. Huang, Sethu Alexander, Jinyan Du, Tweeny Kau, Roman K. Thomas, Kinjal Shah, Horacio Soto, Sven Perner, John Prensner, Ralph M. Debiasi, Francesca Demichelis, Charlie Hatton, Mark A. Rubin, Levi A. Garraway, Stan F. Nelson, Linda Liau, Paul S. Mischel, Tim F. Cloughesy, Matthew Meyerson, Todd A. Golub, Eric S. Lander, Ingo K. Mellinghoff, and William R. Sellers Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20007–20012. Published online 2007 December 6. doi: 10.1073/pnas.0710052104.PMCID: PMC2148413 The preleukemic state of mice reconstituted with Mixl1-transduced marrow cells Donald Metcalf, Stefan Glaser, Sandra Mifsud, Ladina Di Rago, and Lorraine Robb Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20013–20018. Published online 2007 December 3. doi: 10.1073/pnas.0710339104.PMCID: PMC2148414 Microbiology Recruitment of conjugative DNA transfer substrate to Agrobacterium type IV secretion apparatus Minliang Guo, Shouguang Jin, Deying Sun, Choy L. Hew, and Shen Q. Pan Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20019–20024. Published online 2007 December 3. doi: 10.1073/pnas.0701738104.PMCID: PMC2148415 A herpesvirus ubiquitin-specific protease is critical for efficient T cell lymphoma formation Keith Jarosinski, Lisa Kattenhorn, Benedikt Kaufer, Hidde Ploegh, and Nikolaus Osterrieder Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20025–20030. Published online 2007 December 4. doi: 10.1073/pnas.0706295104.PMCID: PMC2148416 Ubiquitin-dependent virus particle budding without viral protein ubiquitination Maria Zhadina, Myra O. McClure, Marc C. Johnson, and Paul D. Bieniasz Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20031–20036. Published online 2007 December 3. doi: 10.1073/pnas.0708002104.PMCID: PMC2148417 Human cytomegalovirus uses two distinct pathways to enter retinal pigmented epithelial cells Dai Wang, Qian-Chun Yu, Jörg Schröer, Eain Murphy, and Thomas Shenk Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20037–20042. Published online 2007 December 5. doi: 10.1073/pnas.0709704104.PMCID: PMC2148418 Mononeme: A new secretory organelle in Plasmodium falciparum merozoites identified by localization of rhomboid-1 protease Subhash Singh, Matthew Plassmeyer, Deepak Gaur, and Louis H. Miller Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20043–20048. Published online 2007 November 28. doi: 10.1073/pnas.0709999104.PMCID: PMC2148419 Neuroscience RET signaling does not modulate MPTP toxicity but is required for regeneration of dopaminergic axon terminals Sebastian Kowsky, Charlotte Pöppelmeyer, Edgar R. Kramer, Björn H. Falkenburger, Anja Kruse, Rüdiger Klein, and Jörg B. Schulz Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20049–20054. Published online 2007 December 4. doi: 10.1073/pnas.0706177104.PMCID: PMC2148420 Trafficking-dependent phosphorylation of Kv1.2 regulates voltage-gated potassium channel cell surface expression Jae-Won Yang, Helene Vacher, Kang-Sik Park, Eliana Clark, and James S. Trimmer Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20055–20060. Published online 2007 December 3. doi: 10.1073/pnas.0708574104.PMCID: PMC2148421 From the Cover: Redirection of cutaneous sensation from the hand to the chest skin of human amputees with targeted reinnervation Todd A. Kuiken, Paul D. Marasco, Blair A. Lock, R. Norman Harden, and Julius P. A. Dewald Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20061–20066. Published online 2007 November 28. doi: 10.1073/pnas.0706525104.PMCID: PMC2148422 Deletion of the core-H region in mice abolishes the expression of three proximal odorant receptor genes in cis Hirofumi Nishizumi, Kouhei Kumasaka, Nobuko Inoue, Ai Nakashima, and Hitoshi Sakano Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20067–20072. Published online 2007 December 5. doi: 10.1073/pnas.0706544105.PMCID: PMC2148423 Perceptual detection as a dynamical bistability phenomenon: A neurocomputational correlate of sensation Gustavo Deco, Mar Pérez-Sanagustín, Victor de Lafuente, and Ranulfo Romo Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20073–20077. Published online 2007 December 5. doi: 10.1073/pnas.0709794104.PMCID: PMC2148424 Two forces for arousal: Pitting hunger versus circadian influences and identifying neurons responsible for changes in behavioral arousal Ana C. Ribeiro, Evelyn Sawa, Isabelle Carren-LeSauter, Joseph LeSauter, Rae Silver, and Donald W. Pfaff Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20078–20083. Published online 2007 December 3. doi: 10.1073/pnas.0710096104.PMCID: PMC2148425 Neural correlates of trust Frank Krueger, Kevin McCabe, Jorge Moll, Nikolaus Kriegeskorte, Roland Zahn, Maren Strenziok, Armin Heinecke, and Jordan Grafman Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20084–20089. Published online 2007 December 4. doi: 10.1073/pnas.0710103104.PMCID: PMC2148426 Homer1a is a core brain molecular correlate of sleep loss Stéphanie Maret, Stéphane Dorsaz, Laure Gurcel, Sylvain Pradervand, Brice Petit, Corinne Pfister, Otto Hagenbuchle, Bruce F. O'Hara, Paul Franken, and Mehdi Tafti Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20090–20095. Published online 2007 December 6. doi: 10.1073/pnas.0710131104.PMCID: PMC2148427 Pharmacology dsAAV type 2-mediated gene transfer of MORS196A-EGFP into spinal cord as a pain management paradigm S. L. Chen, H. I. Ma, J. M. Han, P. L. Tao, P. Y. Law, and H. H. Loh Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20096–20101. Published online 2007 December 4. doi: 10.1073/pnas.0703409104.PMCID: PMC2148428 Physiology A developmental cycle masks output from the circadian oscillator under conditions of choline deficiency in Neurospora Mi Shi, Luis F. Larrondo, Jennifer J. Loros, and Jay C. Dunlap Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20102–20107. Published online 2007 December 4. doi: 10.1073/pnas.0706631104.PMCID: PMC2148429 Loss of skeletal muscle strength by ablation of the sarcoplasmic reticulum protein JP45 Osvaldo Delbono, Jinyu Xia, Susan Treves, Zhong-Min Wang, Ramon Jimenez-Moreno, Anthony M. Payne, María Laura Messi, Alexandre Briguet, Florian Schaerer, Miyuki Nishi, Hiroshi Takeshima, and Francesco Zorzato Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20108–20113. Published online 2007 December 5. doi: 10.1073/pnas.0707389104.PMCID: PMC2148430 Skeletal muscle resists stretch by rapid binding of the second motor domain of myosin to actin Elisabetta Brunello, Massimo Reconditi, Ravikrishnan Elangovan, Marco Linari, Yin-Biao Sun, Theyencheri Narayanan, Pierre Panine, Gabriella Piazzesi, Malcolm Irving, and Vincenzo Lombardi Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20114–20119. Published online 2007 December 6. doi: 10.1073/pnas.0707626104.PMCID: PMC2148431 Phorbol ester stimulation of RasGRP1 regulates the sodium-chloride cotransporter by a PKC-independent pathway Benjamin Ko, Leena M. Joshi, Leslie L. Cooke, Norma Vazquez, Mark W. Musch, Steven C. Hebert, Gerardo Gamba, and Robert S. Hoover Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20120–20125. Published online 2007 December 5. doi: 10.1073/pnas.0709506104.PMCID: PMC2148432 Plant Biology A high-affinity molybdate transporter in eukaryotes Manuel Tejada-Jiménez, Ángel Llamas, Emanuel Sanz-Luque, Aurora Galván, and Emilio Fernández Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20126–20130. Published online 2007 December 5. doi: 10.1073/pnas.0704646104.PMCID: PMC2148433 Pseudomonas syringae type III effector AvrRpt2 alters Arabidopsis thaliana auxin physiology Zhongying Chen, Jennifer L. Agnew, Jerry D. Cohen, Ping He, Libo Shan, Jen Sheen, and Barbara N. Kunkel Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20131–20136. Published online 2007 December 3. doi: 10.1073/pnas.0704901104.PMCID: PMC2148434 Psychology Anterior temporal lobes mediate semantic representation: Mimicking semantic dementia by using rTMS in normal participants Gorana Pobric, Elizabeth Jefferies, and Matthew A. Lambon Ralph Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20137–20141. Published online 2007 December 3. doi: 10.1073/pnas.0707383104.PMCID: PMC2148435 Sustainability Science The impact of climate change on smallholder and subsistence agriculture John F. Morton Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19680–19685. Published online 2007 December 6. doi: 10.1073/pnas.0701855104.PMCID: PMC2148357 Crop and pasture response to climate change Francesco N. Tubiello, Jean-François Soussana, and S. Mark Howden Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19686–19690. Published online 2007 December 6. doi: 10.1073/pnas.0701728104.PMCID: PMC2148358 Adapting agriculture to climate change S. Mark Howden, Jean-François Soussana, Francesco N. Tubiello, Netra Chhetri, Michael Dunlop, and Holger Meinke Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19691–19696. Published online 2007 December 6. doi: 10.1073/pnas.0701890104.PMCID: PMC2148359 Climate change impacts on forestry Andrei P. Kirilenko and Roger A. Sedjo Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19697–19702. Published online 2007 December 6. doi: 10.1073/pnas.0701424104.PMCID: PMC2148360 Global food security under climate change Josef Schmidhuber and Francesco N. Tubiello Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19703–19708. Published online 2007 December 6. doi: 10.1073/pnas.0701976104.PMCID: PMC2148361 Global fish production and climate change K. M. Brander Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19709–19714. Published online 2007 December 6. doi: 10.1073/pnas.0702059104.PMCID: PMC2148362 Social Sciences Anthropology From the Cover: Ancient jades map 3,000 years of prehistoric exchange in Southeast Asia Hsiao-Chun Hung, Yoshiyuki Iizuka, Peter Bellwood, Kim Dung Nguyen, Bérénice Bellina, Praon Silapanth, Eusebio Dizon, Rey Santiago, Ipoi Datan, and Jonathan H. Manton Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19745–19750. Published online 2007 November 29. doi: 10.1073/pnas.0707304104.PMCID: PMC2148369 Economic Sciences Scaling and efficiency determine the irreversible evolution of a market F. Baldovin and A. L. Stella Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19741–19744. Published online 2007 December 5. doi: 10.1073/pnas.0706046104.PMCID: PMC2148368 Psychology The hidden structure of overimitation Derek E. Lyons, Andrew G. Young, and Frank C. Keil Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19751–19756. Published online 2007 December 4. doi: 10.1073/pnas.0704452104.PMCID: PMC2148370 Subliminal exposure to national flags affects political thought and behavior Ran R. Hassin, Melissa J. Ferguson, Daniella Shidlovski, and Tamar Gross Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19757–19761. Published online 2007 December 4. doi: 10.1073/pnas.0704679104.PMCID: PMC2148371 Social Sciences The impact of climate change on smallholder and subsistence agriculture John F. Morton Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19680–19685. Published online 2007 December 6. doi: 10.1073/pnas.0701855104.PMCID: PMC2148357 From the Cover: Other-regarding preferences in a non-human primate: Common marmosets provision food altruistically Judith M. Burkart, Ernst Fehr, Charles Efferson, and Carel P. van Schaik Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 19762–19766. Published online 2007 December 5. doi: 10.1073/pnas.0710310104.PMCID: PMC2148372 Corrections Correction for This Week in PNAS Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20142. doi: 10.1073/pnas.0710562104.PMCID: PMC2148436 Corrects: In This Issue. Proc Natl Acad Sci U S A. 2007 October 16; 104(42): 16391–16392. Correction for Lewis and Nocera, Powering the planet: Chemical challenges in solar energy utilization Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20142. doi: 10.1073/pnas.0710683104.PMCID: PMC2148437 Corrects: Nathan S. Lewis, et al. Powering the planet: Chemical challenges in solar energy utilization. Proc Natl Acad Sci U S A. 2006 October 24; 103(43): 15729–15735. Correction for Panfilov et al., Drift and breakup of spiral waves in reaction–diffusion–mechanics systems Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20142. doi: 10.1073/pnas.0710559104.PMCID: PMC2148438 Corrects: A. V. Panfilov, et al. Drift and breakup of spiral waves in reaction–diffusion–mechanics systems. Proc Natl Acad Sci U S A. 2007 May 8; 104(19): 7922–7926. Correction for Lim and Kai, Unique germ-line organelle, nuage, functions to repress selfish genetic elements in Drosophila melanogaster Proc Natl Acad Sci U S A. 2007 December 11; 104(50): 20143. Published online 2007 November 15. doi: 10.1073/pnas.0710102104.PMCID: PMC2148439 Corrects: Ai Khim Lim, et al. Unique germ-line organelle, nuage, functions to repress selfish genetic elements in Drosophila melanogaster. Proc Natl Acad Sci U S A. 2007 April 17; 104(16): 6714–6719. |