| | This journal provides immediate access to some articles. Inaugural Article A mathematical tool for exploring the dynamics of biological networks Paolo E. Barbano, Marina Spivak, Marc Flajolet, Angus C. Nairn, Paul Greengard, and Leslie Greengard Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19169–19174. Published online 2007 November 21. doi: 10.1073/pnas.0709955104.PMCID: PMC2148263 This Week in PNAS Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19161–19162. doi: 10.1073/iti4907104.PMCID: PMC2148259 Commentaries The discovery of kelp forests in deep-water habitats of tropical regions Bernabé Santelices Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19163–19164. Published online 2007 November 27. doi: 10.1073/pnas.0708963104.PMCID: PMC2148260 Clinical implications of the loss of vasoactive nitric oxide during red blood cell storage Joseph Bonaventura Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19165–19166. Published online 2007 November 28. doi: 10.1073/pnas.0708871105.PMCID: PMC2148261 Savanna chimpanzees dig for food W. C. McGrew Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19167–19168. Published online 2007 November 28. doi: 10.1073/pnas.0710330105.PMCID: PMC2148262 Physical Sciences Applied Mathematics A mathematical tool for exploring the dynamics of biological networks Paolo E. Barbano, Marina Spivak, Marc Flajolet, Angus C. Nairn, Paul Greengard, and Leslie Greengard Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19169–19174. Published online 2007 November 21. doi: 10.1073/pnas.0709955104.PMCID: PMC2148263 Subnetwork analysis reveals dynamic features of complex (bio)chemical networks Carsten Conradi, Dietrich Flockerzi, Jörg Raisch, and Jörg Stelling Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19175–19180. Published online 2007 November 27. doi: 10.1073/pnas.0705731104.PMCID: PMC2148257 Chemistry Axial ligand tuning of a nonheme iron(IV)–oxo unit for hydrogen atom abstraction Chivukula V. Sastri, Jimin Lee, Kyungeun Oh, Yoon Jin Lee, Junghyun Lee, Timothy A. Jackson, Kallol Ray, Hajime Hirao, Woonsup Shin, Jason A. Halfen, Jinheung Kim, Lawrence Que, Jr, Sason Shaik, and Wonwoo Nam Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19181–19186. Published online 2007 November 28. doi: 10.1073/pnas.0709471104.PMCID: PMC2148264 Physics Symmetry, shape, and order Antonio Trovato, Trinh Xuan Hoang, Jayanth R. Banavar, and Amos Maritan Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19187–19192. Published online 2007 November 21. doi: 10.1073/pnas.0707523104.PMCID: PMC2148265 Does the h index have predictive power? J. E. Hirsch Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19193–19198. Published online 2007 November 26. doi: 10.1073/pnas.0707962104.PMCID: PMC2148266 Statistics A forest-based approach to identifying gene and gene–gene interactions Xiang Chen, Ching-Ti Liu, Meizhuo Zhang, and Heping Zhang Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19199–19203. Published online 2007 November 28. doi: 10.1073/pnas.0709868104.PMCID: PMC2148267 Biological Sciences Anthropology From the Cover: Savanna chimpanzees use tools to harvest the underground storage organs of plants R. Adriana Hernandez-Aguilar, Jim Moore, and Travis Rayne Pickering Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19210–19213. Published online 2007 November 21. doi: 10.1073/pnas.0707929104.PMCID: PMC2148269 Global climate change, war, and population decline in recent human history David D. Zhang, Peter Brecke, Harry F. Lee, Yuan-Qing He, and Jane Zhang Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19214–19219. Published online 2007 November 28. doi: 10.1073/pnas.0703073104.PMCID: PMC2148270 A new Late Miocene great ape from Kenya and its implications for the origins of African great apes and humans Yutaka Kunimatsu, Masato Nakatsukasa, Yoshihiro Sawada, Tetsuya Sakai, Masayuki Hyodo, Hironobu Hyodo, Tetsumaru Itaya, Hideo Nakaya, Haruo Saegusa, Arnaud Mazurier, Mototaka Saneyoshi, Hiroshi Tsujikawa, Ayumi Yamamoto, and Emma Mbua Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19220–19225. Published online 2007 November 16. doi: 10.1073/pnas.0706190104.PMCID: PMC2148271 Biochemistry A mathematical tool for exploring the dynamics of biological networks Paolo E. Barbano, Marina Spivak, Marc Flajolet, Angus C. Nairn, Paul Greengard, and Leslie Greengard Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19169–19174. Published online 2007 November 21. doi: 10.1073/pnas.0709955104.PMCID: PMC2148263 JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer Yang Xiang, Ziqi Zhu, Gang Han, Xiaolei Ye, Bo Xu, Zhouchun Peng, Yuanjun Ma, Yi Yu, Hanqing Lin, Adele Pin Chen, and Charlie Degui Chen Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19226–19231. Published online 2007 November 28. doi: 10.1073/pnas.0700735104.PMCID: PMC2148272 Directed selection of a conformational antibody domain that prevents mature amyloid fibril formation by stabilizing Aβ protofibrils Gernot Habicht, Christian Haupt, Ralf P. Friedrich, Peter Hortschansky, Carsten Sachse, Jessica Meinhardt, Karin Wieligmann, Gerald P. Gellermann, Michael Brodhun, Jürgen Götz, Karl-Jürgen Halbhuber, Christoph Röcken, Uwe Horn, and Marcus Fändrich Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19232–19237. Published online 2007 November 27. doi: 10.1073/pnas.0703793104.PMCID: PMC2148273 Epidermal growth factor receptor juxtamembrane region regulates allosteric tyrosine kinase activation Kristina W. Thiel and Graham Carpenter Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19238–19243. Published online 2007 November 27. doi: 10.1073/pnas.0703854104.PMCID: PMC2148274 Antiinflammatory glucocorticoid receptor ligand with reduced side effects exhibits an altered protein–protein interaction profile Jeffrey N. Miner, Bob Ardecky, Khalid Benbatoul, Kimberly Griffiths, Christopher J. Larson, Dale E. Mais, Keith Marschke, Jon Rosen, Eric Vajda, Lin Zhi, and Andres Negro-Vilar Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19244–19249. Published online 2007 November 21. doi: 10.1073/pnas.0705517104.PMCID: PMC2148275 Mitochondrial origin-binding protein UMSBP mediates DNA replication and segregation in trypanosomes Neta Milman, Shawn A. Motyka, Paul T. Englund, Derrick Robinson, and Joseph Shlomai Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19250–19255. Published online 2007 November 28. doi: 10.1073/pnas.0706858104.PMCID: PMC2148276 Protein–protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef protein Stéphane Betzi, Audrey Restouin, Sandrine Opi, Stefan T. Arold, Isabelle Parrot, Françoise Guerlesquin, Xavier Morelli, and Yves Collette Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19256–19261. Published online 2007 November 27. doi: 10.1073/pnas.0707130104.PMCID: PMC2148277 Laforin is a glycogen phosphatase, deficiency of which leads to elevated phosphorylation of glycogen in vivo Vincent S. Tagliabracci, Julie Turnbull, Wei Wang, Jean-Marie Girard, Xiaochu Zhao, Alexander V. Skurat, Antonio V. Delgado-Escueta, Berge A. Minassian, Anna A. DePaoli-Roach, and Peter J. Roach Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19262–19266. Published online 2007 November 26. doi: 10.1073/pnas.0707952104.PMCID: PMC2148278 A novel polydnavirus protein inhibits the insect prophenoloxidase activation pathway Markus H. Beck and Michael R. Strand Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19267–19272. Published online 2007 November 21. doi: 10.1073/pnas.0708056104.PMCID: PMC2148279 The all-trans-retinal dimer series of lipofuscin pigments in retinal pigment epithelial cells in a recessive Stargardt disease model So R. Kim, Young P. Jang, Steffen Jockusch, Nathan E. Fishkin, Nicholas J. Turro, and Janet R. Sparrow Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19273–19278. Published online 2007 November 28. doi: 10.1073/pnas.0708714104.PMCID: PMC2148280 Structure of the Nitrosomonas europaea Rh protein Xin Li, Sanjay Jayachandran, Hiep-Hoa T. Nguyen, and Michael K. Chan Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19279–19284. Published online 2007 November 26. doi: 10.1073/pnas.0709710104.PMCID: PMC2148281 Regulation of hypothalamic malonyl-CoA by central glucose and leptin Michael J. Wolfgang, Seung Hun Cha, Aniket Sidhaye, Shigeru Chohnan, Gary Cline, Gerald I. Shulman, and M. Daniel Lane Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19285–19290. Published online 2007 November 21. doi: 10.1073/pnas.0709778104.PMCID: PMC2148282 A biochemical approach to identifying microRNA targets Fedor V. Karginov, Cecilia Conaco, Zhenyu Xuan, Bryan H. Schmidt, Joel S. Parker, Gail Mandel, and Gregory J. Hannon Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19291–19296. Published online 2007 November 27. doi: 10.1073/pnas.0709971104.PMCID: PMC2148283 Biophysics Construction of effective free energy landscape from single-molecule time series Akinori Baba and Tamiki Komatsuzaki Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19297–19302. Published online 2007 November 28. doi: 10.1073/pnas.0704167104.PMCID: PMC2148284 The 1.3-Å resolution structure of Nitrosomonas europaea Rh50 and mechanistic implications for NH3 transport by Rhesus family proteins Domenico Lupo, Xiao-Dan Li, Anne Durand, Takashi Tomizaki, Baya Cherif-Zahar, Giorgio Matassi, Mike Merrick, and Fritz K. Winkler Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19303–19308. Published online 2007 November 21. doi: 10.1073/pnas.0706563104.PMCID: PMC2148285 Disulfide bond influence on protein structural dynamics probed with 2D-IR vibrational echo spectroscopy Haruto Ishikawa, Seongheun Kim, Kyungwon Kwak, Keisuke Wakasugi, and Michael D. Fayer Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19309–19314. Published online 2007 November 27. doi: 10.1073/pnas.0709760104.PMCID: PMC2148286 Cryo-EM study of the spinach chloroplast ribosome reveals the structural and functional roles of plastid-specific ribosomal proteins Manjuli R. Sharma, Daniel N. Wilson, Partha P. Datta, Chandana Barat, Frank Schluenzen, Paola Fucini, and Rajendra K. Agrawal Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19315–19320. Published online 2007 November 27. doi: 10.1073/pnas.0709856104.PMCID: PMC2148287 Mechanoenzymes under superstall and large assisting loads reveal structural features Denis Tsygankov and Michael E. Fisher Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19321–19326. Published online 2007 November 28. doi: 10.1073/pnas.0709911104.PMCID: PMC2148288 Cell Biology Subnetwork analysis reveals dynamic features of complex (bio)chemical networks Carsten Conradi, Dietrich Flockerzi, Jörg Raisch, and Jörg Stelling Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19175–19180. Published online 2007 November 27. doi: 10.1073/pnas.0705731104.PMCID: PMC2148257 Matrix metalloproteinase 7 controls pancreatic acinar cell transdifferentiation by activating the Notch signaling pathway Eric T. Sawey, Johnny A. Johnson, and Howard C. Crawford Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19327–19332. Published online 2007 November 27. doi: 10.1073/pnas.0705953104.PMCID: PMC2148289 Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP Tadao Shibasaki, Harumi Takahashi, Takashi Miki, Yasuhiro Sunaga, Kimio Matsumura, Mami Yamanaka, Changliang Zhang, Atsuko Tamamoto, Takaya Satoh, Jun-ichi Miyazaki, and Susumu Seino Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19333–19338. Published online 2007 November 26. doi: 10.1073/pnas.0707054104.PMCID: PMC2148290 Structural differentiation of skeletal muscle fibers in the absence of innervation in humans Simona Boncompagni, Helmut Kern, Katia Rossini, Christian Hofer, Winfried Mayr, Ugo Carraro, and Feliciano Protasi Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19339–19344. Published online 2007 November 27. doi: 10.1073/pnas.0709061104.PMCID: PMC2148291 Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis Ralph J. DeBerardinis, Anthony Mancuso, Evgueni Daikhin, Ilana Nissim, Marc Yudkoff, Suzanne Wehrli, and Craig B. Thompson Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19345–19350. Published online 2007 November 21. doi: 10.1073/pnas.0709747104.PMCID: PMC2148292 Developmental Biology DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status Kevin D. Sinclair, Cinzia Allegrucci, Ravinder Singh, David S. Gardner, Sonia Sebastian, Jayson Bispham, Alexandra Thurston, John F. Huntley, William D. Rees, Christopher A. Maloney, Richard G. Lea, Jim Craigon, Tom G. McEvoy, and Lorraine E. Young Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19351–19356. Published online 2007 November 27. doi: 10.1073/pnas.0707258104.PMCID: PMC2148293 From the Cover: Blocking LIF action in the uterus by using a PEGylated antagonist prevents implantation: A nonhormonal contraceptive strategy Christine A. White, Jian-Guo Zhang, Lois A. Salamonsen, Manuel Baca, W. Douglas Fairlie, Donald Metcalf, Nicos A. Nicola, Lorraine Robb, and Evdokia Dimitriadis Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19357–19362. Published online 2007 November 27. doi: 10.1073/pnas.0710110104.PMCID: PMC2148294 Evolution Using plastid genome-scale data to resolve enigmatic relationships among basal angiosperms Michael J. Moore, Charles D. Bell, Pamela S. Soltis, and Douglas E. Soltis Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19363–19368. Published online 2007 November 28. doi: 10.1073/pnas.0708072104.PMCID: PMC2148295 Analysis of 81 genes from 64 plastid genomes resolves relationships in angiosperms and identifies genome-scale evolutionary patterns Robert K. Jansen, Zhengqiu Cai, Linda A. Raubeson, Henry Daniell, Claude W. dePamphilis, James Leebens-Mack, Kai F. Müller, Mary Guisinger-Bellian, Rosemarie C. Haberle, Anne K. Hansen, Timothy W. Chumley, Seung-Bum Lee, Rhiannon Peery, Joel R. McNeal, Jennifer V. Kuehl, and Jeffrey L. Boore Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19369–19374. Published online 2007 November 28. doi: 10.1073/pnas.0709121104.PMCID: PMC2148296 Long-term evolution of transposable elements Arnaud Le Rouzic, Thibaud S. Boutin, and Pierre Capy Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19375–19380. Published online 2007 November 26. doi: 10.1073/pnas.0705238104.PMCID: PMC2148297 From the Cover: The signal environment is more important than diet or chemical specialization in the evolution of warning coloration Kathleen L. Prudic, Jeffrey C. Oliver, and Felix A. H. Sperling Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19381–19386. Published online 2007 November 20. doi: 10.1073/pnas.0705478104.PMCID: PMC2148298 Genetic variation in the cysteine biosynthesis pathway causes sensitivity to pharmacological compounds Hyun Seok Kim and Justin C. Fay Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19387–19391. Published online 2007 November 27. doi: 10.1073/pnas.0708194104.PMCID: PMC2148299 Parallel genomic evolution and metabolic interdependence in an ancient symbiosis John P. McCutcheon and Nancy A. Moran Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19392–19397. Published online 2007 November 28. doi: 10.1073/pnas.0708855104.PMCID: PMC2148300 Extensive simple sequence repeat genotyping of potato landraces supports a major reevaluation of their gene pool structure and classification David M. Spooner, Jorge Núñez, Guillermo Trujillo, María del Rosario Herrera, Frank Guzmán, and Marc Ghislain Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19398–19403. Published online 2007 November 27. doi: 10.1073/pnas.0709796104.PMCID: PMC2148301 Evolutionary plasticity of developmental gene regulatory network architecture Veronica F. Hinman and Eric H. Davidson Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19404–19409. Published online 2007 November 27. doi: 10.1073/pnas.0709994104.PMCID: PMC2148302 Genetics A forest-based approach to identifying gene and gene–gene interactions Xiang Chen, Ching-Ti Liu, Meizhuo Zhang, and Heping Zhang Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19199–19203. Published online 2007 November 28. doi: 10.1073/pnas.0709868104.PMCID: PMC2148267 Pseudouridylation of helix 69 of 23S rRNA is necessary for an effective translation termination Morten Ejby, Michael A. Sørensen, and Steen Pedersen Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19410–19415. Published online 2007 November 21. doi: 10.1073/pnas.0706558104.PMCID: PMC2148303 Integrated epigenomic analyses of neuronal MeCP2 reveal a role for long-range interaction with active genes Dag H. Yasui, Sailaja Peddada, Mark C. Bieda, Roxanne O. Vallero, Amber Hogart, Raman P. Nagarajan, Karen N. Thatcher, Peggy J. Farnham, and Janine M. LaSalle Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19416–19421. Published online 2007 November 27. doi: 10.1073/pnas.0707442104.PMCID: PMC2148304 A knockin mouse model of the Bardet–Biedl syndrome 1 M390R mutation has cilia defects, ventriculomegaly, retinopathy, and obesity Roger E. Davis, Ruth E. Swiderski, Kamal Rahmouni, Darryl Y. Nishimura, Robert F. Mullins, Khristofor Agassandian, Alisdair R. Philp, Charles C. Searby, Michael P. Andrews, Stewart Thompson, Christopher J. Berry, Daniel R. Thedens, Baoli Yang, Robert M. Weiss, Martin D. Cassell, Edwin M. Stone, and Val C. Sheffield Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19422–19427. Published online 2007 November 21. doi: 10.1073/pnas.0708571104.PMCID: PMC2148305 From the Cover: Distinguishing protein-coding and noncoding genes in the human genome Michele Clamp, Ben Fry, Mike Kamal, Xiaohui Xie, James Cuff, Michael F. Lin, Manolis Kellis, Kerstin Lindblad-Toh, and Eric S. Lander Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19428–19433. Published online 2007 November 26. doi: 10.1073/pnas.0709013104.PMCID: PMC2148306 Immunology Histamine is stored in mast cells of most evolutionarily advanced fish and regulates the fish inflammatory response Iván Mulero, M. Pilar Sepulcre, José Meseguer, Alfonsa García-Ayala, and Victoriano Mulero Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19434–19439. Published online 2007 November 27. doi: 10.1073/pnas.0704535104.PMCID: PMC2148307 Chronic stimulation of Nod2 mediates tolerance to bacterial products Matija Hedl, Jing Li, Judy H. Cho, and Clara Abraham Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19440–19445. Published online 2007 November 21. doi: 10.1073/pnas.0706097104.PMCID: PMC2148308 CD4+CD25+Foxp3+ regulatory T cells induce alternative activation of human monocytes/macrophages Machteld M. Tiemessen, Ann L. Jagger, Hayley G. Evans, Martijn J. C. van Herwijnen, Susan John, and Leonie S. Taams Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19446–19451. Published online 2007 November 27. doi: 10.1073/pnas.0706832104.PMCID: PMC2148309 Assembly and structural properties of glucocorticoid-induced TNF receptor ligand: Implications for function Kausik Chattopadhyay, Udupi A. Ramagopal, Arunika Mukhopadhaya, Vladimir N. Malashkevich, Teresa P. DiLorenzo, Michael Brenowitz, Stanley G. Nathenson, and Steven C. Almo Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19452–19457. Published online 2007 November 26. doi: 10.1073/pnas.0709264104.PMCID: PMC2148310 B7-H3 and B7x are highly expressed in human prostate cancer and associated with disease spread and poor outcome Xingxing Zang, R. Houston Thompson, Hikmat A. Al-Ahmadie, Angel M. Serio, Victor E. Reuter, James A. Eastham, Peter T. Scardino, Padmanee Sharma, and James P. Allison Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19458–19463. Published online 2007 November 27. doi: 10.1073/pnas.0709802104.PMCID: PMC2148311 Medical Sciences Syndecan-3 is a dendritic cell-specific attachment receptor for HIV-1 Lot de Witte, Michael Bobardt, Udayan Chatterji, Gisèle Degeest, Guido David, Teunis B. H. Geijtenbeek, and Philippe Gallay Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19464–19469. Published online 2007 November 26. doi: 10.1073/pnas.0703747104.PMCID: PMC2148312 Dynamic interplay between nitration and phosphorylation of tubulin cofactor B in the control of microtubule dynamics Suresh K. Rayala, Emil Martin, Iraida G. Sharina, Poonam R. Molli, Xiaoping Wang, Raymond Jacobson, Ferid Murad, and Rakesh Kumar Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19470–19475. Published online 2007 November 28. doi: 10.1073/pnas.0705149104.PMCID: PMC2148313 Silencing of OB-RGRP in mouse hypothalamic arcuate nucleus increases leptin receptor signaling and prevents diet-induced obesity Cyril Couturier, Chamsy Sarkis, Karin Séron, Sandrine Belouzard, Patty Chen, Aude Lenain, Laetitia Corset, Julie Dam, Virginie Vauthier, Anne Dubart, Jacques Mallet, Philippe Froguel, Yves Rouillé, and Ralf Jockers Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19476–19481. Published online 2007 November 27. doi: 10.1073/pnas.0706671104.PMCID: PMC2148314 HDAC inhibitor PCI-24781 decreases RAD51 expression and inhibits homologous recombination Shanthi Adimoolam, Mint Sirisawad, Jun Chen, Patti Thiemann, James M. Ford, and Joseph J. Buggy Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19482–19487. Published online 2007 November 27. doi: 10.1073/pnas.0707828104.PMCID: PMC2148315 Tumor cell-selective regulation of NOXA by c-MYC in response to proteasome inhibition Mikhail A. Nikiforov, MaryBeth Riblett, Wen-Hua Tang, Vladimir Gratchouck, Dazhong Zhuang, Yolanda Fernandez, Monique Verhaegen, Sooryanarayana Varambally, Arul M. Chinnaiyan, Andrzej J. Jakubowiak, and Maria S. Soengas Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19488–19493. Published online 2007 November 27. doi: 10.1073/pnas.0708380104.PMCID: PMC2148316 In vivo multiphoton microscopy of NADH and FAD redox states, fluorescence lifetimes, and cellular morphology in precancerous epithelia Melissa C. Skala, Kristin M. Riching, Annette Gendron-Fitzpatrick, Jens Eickhoff, Kevin W. Eliceiri, John G. White, and Nirmala Ramanujam Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19494–19499. Published online 2007 November 27. doi: 10.1073/pnas.0708425104.PMCID: PMC2148317 NIX is required for programmed mitochondrial clearance during reticulocyte maturation Rachel L. Schweers, Ji Zhang, Mindy S. Randall, Melanie R. Loyd, Weimin Li, Frank C. Dorsey, Mondira Kundu, Joseph T. Opferman, John L. Cleveland, Jeffery L. Miller, and Paul A. Ney Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19500–19505. Published online 2007 November 29. doi: 10.1073/pnas.0708818104.PMCID: PMC2148318 ID genes mediate tumor reinitiation during breast cancer lung metastasis Gaorav P. Gupta, Jonathan Perk, Swarnali Acharyya, Paola de Candia, Vivek Mittal, Katia Todorova-Manova, William L. Gerald, Edi Brogi, Robert Benezra, and Joan Massagué Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19506–19511. Published online 2007 November 28. doi: 10.1073/pnas.0709185104.PMCID: PMC2148319 Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis Mai Nguyen, Richard C. Marcellus, Anne Roulston, Mark Watson, Lucile Serfass, S. R. Murthy Madiraju, Daniel Goulet, Jean Viallet, Laurent Bélec, Xavier Billot, Stephane Acoca, Enrico Purisima, Adrian Wiegmans, Leonie Cluse, Ricky W. Johnstone, Pierre Beauparlant, and Gordon C. Shore Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19512–19517. Published online 2007 November 26. doi: 10.1073/pnas.0709443104.PMCID: PMC2148320 Microbiology Cytoskeletal “jellyfish” structure of Mycoplasma mobile Daisuke Nakane and Makoto Miyata Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19518–19523. Published online 2007 November 27. doi: 10.1073/pnas.0704280104.PMCID: PMC2148321 Rapid magnetosome formation shown by real-time x-ray magnetic circular dichroism Sarah Staniland, Bruce Ward, Andrew Harrison, Gerrit van der Laan, and Neil Telling Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19524–19528. Published online 2007 November 21. doi: 10.1073/pnas.0704879104.PMCID: PMC2148322 Substrate binding by a bacterial ABC transporter involved in polysaccharide export Leslie Cuthbertson, Matthew S. Kimber, and Chris Whitfield Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19529–19534. Published online 2007 November 21. doi: 10.1073/pnas.0705709104.PMCID: PMC2148323 Crystal structure of measles virus hemagglutinin provides insight into effective vaccines Takao Hashiguchi, Mizuho Kajikawa, Nobuo Maita, Makoto Takeda, Kimiko Kuroki, Kaori Sasaki, Daisuke Kohda, Yusuke Yanagi, and Katsumi Maenaka Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19535–19540. Published online 2007 November 14. doi: 10.1073/pnas.0707830104.PMCID: PMC2148324 Human papillomaviruses activate caspases upon epithelial differentiation to induce viral genome amplification Cary A. Moody, Amelie Fradet-Turcotte, Jacques Archambault, and Laimonis A. Laimins Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19541–19546. Published online 2007 November 28. doi: 10.1073/pnas.0707947104.PMCID: PMC2148325 The P2 capsid protein of the nonenveloped rice dwarf phytoreovirus induces membrane fusion in insect host cells Feng Zhou, Yingying Pu, Taiyuan Wei, Huijun Liu, Wulan Deng, Chunhong Wei, Biao Ding, Toshihiro Omura, and Yi Li Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19547–19552. Published online 2007 November 27. doi: 10.1073/pnas.0708946104.PMCID: PMC2148326 Neuroscience The blinking spotlight of attention Rufin VanRullen, Thomas Carlson, and Patrick Cavanagh Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19204–19209. Published online 2007 November 27. doi: 10.1073/pnas.0707316104.PMCID: PMC2148268 Regulation of spine morphology and spine density by NMDA receptor signaling in vivo Sila K. Ultanir, Ji-Eun Kim, Benjamin J. Hall, Thomas Deerinck, Mark Ellisman, and Anirvan Ghosh Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19553–19558. Published online 2007 November 28. doi: 10.1073/pnas.0704031104.PMCID: PMC2148327 Modulation of metabolic brain networks after subthalamic gene therapy for Parkinson's disease Andrew Feigin, Michael G. Kaplitt, Chengke Tang, Tanya Lin, Paul Mattis, Vijay Dhawan, Matthew J. During, and David Eidelberg Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19559–19564. Published online 2007 November 27. doi: 10.1073/pnas.0706006104.PMCID: PMC2148328 Redundant and unique roles of retinol dehydrogenases in the mouse retina Akiko Maeda, Tadao Maeda, Wenyu Sun, Houbin Zhang, Wolfgang Baehr, and Krzysztof Palczewski Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19565–19570. Published online 2007 November 28. doi: 10.1073/pnas.0707477104.PMCID: PMC2148329 A structural basis for enhancement of long-term associative memory in single dendritic spines regulated by PKC Jarin Hongpaisan and Daniel L. Alkon Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19571–19576. Published online 2007 December 4. doi: 10.1073/pnas.0709311104.PMCID: PMC2148330 Specific subgroups of FruM neurons control sexually dimorphic patterns of aggression in Drosophila melanogaster Yick-Bun Chan and Edward A. Kravitz Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19577–19582. Published online 2007 November 27. doi: 10.1073/pnas.0709803104.PMCID: PMC2148331 A helix-breaking mutation in TRPML3 leads to constitutive activity underlying deafness in the varitint-waddler mouse Christian Grimm, Math P. Cuajungco, Alexander F. J. van Aken, Michael Schnee, Simone Jörs, Corné J. Kros, Anthony J. Ricci, and Stefan Heller Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19583–19588. Published online 2007 November 28. doi: 10.1073/pnas.0709846104.PMCID: PMC2148332 Pharmacology Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha Xiu Jun Wang, John D. Hayes, Colin J. Henderson, and C. Roland Wolf Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19589–19594. Published online 2007 November 28. doi: 10.1073/pnas.0709483104.PMCID: PMC2148333 Acute-phase protein α-1-acid glycoprotein mediates neutrophil migration failure in sepsis by a nitric oxide-dependent mechanism F. L. A. C. Mestriner, F. Spiller, H. J. Laure, F. O. Souto, B. M. Tavares-Murta, J. C. Rosa, A. Basile-Filho, S. H. Ferreira, L. J. Greene, and F. Q. Cunha Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19595–19600. Published online 2007 November 28. doi: 10.1073/pnas.0709681104.PMCID: PMC2148334 Physiology β cell-specific deficiency of the stimulatory G protein α-subunit Gsα leads to reduced β cell mass and insulin-deficient diabetes Tao Xie, Min Chen, Qing-Hong Zhang, Zheng Ma, and Lee S. Weinstein Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19601–19606. Published online 2007 November 20. doi: 10.1073/pnas.0704796104.PMCID: PMC2148335 Yeast gain-of-function mutations reveal structure–function relationships conserved among different subfamilies of transient receptor potential channels Zhenwei Su, Xinliang Zhou, W. John Haynes, Stephen H. Loukin, Andriy Anishkin, Yoshiro Saimi, and Ching Kung Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19607–19612. Published online 2007 November 27. doi: 10.1073/pnas.0708584104.PMCID: PMC2148336 Plant Biology CERK1, a LysM receptor kinase, is essential for chitin elicitor signaling in Arabidopsis Ayako Miya, Premkumar Albert, Tomonori Shinya, Yoshitake Desaki, Kazuya Ichimura, Ken Shirasu, Yoshihiro Narusaka, Naoto Kawakami, Hanae Kaku, and Naoto Shibuya Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19613–19618. Published online 2007 November 27. doi: 10.1073/pnas.0705147104.PMCID: PMC2148337 Phloem loading in Verbascum phoeniceum L. depends on the synthesis of raffinose-family oligosaccharides Ashlee McCaskill and Robert Turgeon Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19619–19624. Published online 2007 November 28. doi: 10.1073/pnas.0707368104.PMCID: PMC2148338 AUREOCHROME, a photoreceptor required for photomorphogenesis in stramenopiles Fumio Takahashi, Daisuke Yamagata, Mié Ishikawa, Yosuke Fukamatsu, Yasunobu Ogura, Masahiro Kasahara, Tomohiro Kiyosue, Munehiro Kikuyama, Masamitsu Wada, and Hironao Kataoka Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19625–19630. Published online 2007 November 14. doi: 10.1073/pnas.0707692104.PMCID: PMC2148339 Delayed leaf senescence induces extreme drought tolerance in a flowering plant Rosa M. Rivero, Mikiko Kojima, Amira Gepstein, Hitoshi Sakakibara, Ron Mittler, Shimon Gepstein, and Eduardo Blumwald Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19631–19636. Published online 2007 November 28. doi: 10.1073/pnas.0709453104.PMCID: PMC2148340 Vitamin B1 biosynthesis in plants requires the essential iron–sulfur cluster protein, THIC Maja Raschke, Lukas Bürkle, Nadine Müller, Adriano Nunes-Nesi, Alisdair R. Fernie, Duilio Arigoni, Nikolaus Amrhein, and Teresa B. Fitzpatrick Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19637–19642. Published online 2007 November 28. doi: 10.1073/pnas.0709597104.PMCID: PMC2148341 Psychology Task-specific change of unconscious neural priming in the cerebral language network Kimihiro Nakamura, Stanislas Dehaene, Antoinette Jobert, Denis Le Bihan, and Sid Kouider Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19643–19648. Published online 2007 November 27. doi: 10.1073/pnas.0704487104.PMCID: PMC2148342 From the Cover: Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation P. Shaw, K. Eckstrand, W. Sharp, J. Blumenthal, J. P. Lerch, D. Greenstein, L. Clasen, A. Evans, J. Giedd, and J. L. Rapoport Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19649–19654. Published online 2007 November 16. doi: 10.1073/pnas.0707741104.PMCID: PMC2148343 Social Sciences Psychology The blinking spotlight of attention Rufin VanRullen, Thomas Carlson, and Patrick Cavanagh Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19204–19209. Published online 2007 November 27. doi: 10.1073/pnas.0707316104.PMCID: PMC2148268 Corrections Correction for Zhou et al., Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19655–19656. Published online 2007 November 15. doi: 10.1073/pnas.0710050104.PMCID: PMC2148344 Corrects: Jiangbing Zhou, et al. Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance. Proc Natl Acad Sci U S A. 2007 October 9; 104(41): 16158–16163. Correction for Wittmann et al., Isolates of Zaire ebolavirus from wild apes reveal genetic lineage and recombinants Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19656. Published online 2007 November 15. doi: 10.1073/pnas.0710178104.PMCID: PMC2148345 Corrects: Tatiana J. Wittmann, et al. Isolates of Zaire ebolavirus from wild apes reveal genetic lineage and recombinants. Proc Natl Acad Sci U S A. 2007 October 23; 104(43): 17123–17127. Correction for Soto et al., Dissociating the neural mechanisms of memory-based guidance of visual selection Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19656. Published online 2007 November 15. doi: 10.1073/pnas.0710119104.PMCID: PMC2148346 Corrects: David Soto, et al. Dissociating the neural mechanisms of memory-based guidance of visual selection. Proc Natl Acad Sci U S A. 2007 October 23; 104(43): 17186–17191. Correction for Natarajan et al., The EGF receptor is required for efficient liver regeneration Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19656. Published online 2007 November 15. doi: 10.1073/pnas.0710101104.PMCID: PMC2148347 Corrects: Anuradha Natarajan, et al. The EGF receptor is required for efficient liver regeneration. Proc Natl Acad Sci U S A. 2007 October 23; 104(43): 17081–17086. Correction for Sanchez et al., Poverty and Hunger Special Feature: The African Millennium Villages Proc Natl Acad Sci U S A. 2007 December 4; 104(49): 19656. Published online 2007 November 15. doi: 10.1073/pnas.0710170104.PMCID: PMC2148348 Corrects: Pedro Sanchez, et al. Poverty And Hunger Special Feature: The African Millennium Villages. Proc Natl Acad Sci U S A. 2007 October 23; 104(43): 16775–16780. |