| | This journal provides immediate access to some articles. This Week in PNAS Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2027–2028. doi: 10.1073/iti0707104.PMCID: PMC1892932 Commentaries Probing the interactions of proteins and nanoparticles Jacob Klein Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2029–2030. Published online 2007 February 6. doi: 10.1073/pnas.0611610104.PMCID: PMC1892940 Uniformity amid diversity in RNase P Venkat Gopalan Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2031–2032. Published online 2007 February 7. doi: 10.1073/pnas.0611193104.PMCID: PMC1892978 How to keep photoreceptors alive Alan Bird Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2033–2034. Published online 2007 February 6. doi: 10.1073/pnas.0611014104.PMCID: PMC1892987 Physical Sciences Chemistry From the Cover: Understanding the nanoparticle–protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles Tommy Cedervall, Iseult Lynch, Stina Lindman, Tord Berggård, Eva Thulin, Hanna Nilsson, Kenneth A. Dawson, and Sara Linse Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2050–2055. Published online 2007 January 31. doi: 10.1073/pnas.0608582104.PMCID: PMC1892985 A catalytic beacon sensor for uranium with parts-per-trillion sensitivity and millionfold selectivity Juewen Liu, Andrea K. Brown, Xiangli Meng, Donald M. Cropek, Jonathan D. Istok, David B. Watson, and Yi Lu Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2056–2061. Published online 2007 February 6. doi: 10.1073/pnas.0607875104.PMCID: PMC1892917 Substrate product equilibrium on a reversible enzyme, triosephosphate isomerase Sharon Rozovsky and Ann E. McDermott Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2080–2085. Published online 2007 February 7. doi: 10.1073/pnas.0608876104.PMCID: PMC1794347 Long-distance combinatorial linkage between methylation and acetylation on histone H3 N termini Sean D. Taverna, Beatrix M. Ueberheide, Yifan Liu, Alan J. Tackett, Robert L. Diaz, Jeffrey Shabanowitz, Brian T. Chait, Donald F. Hunt, and C. David Allis Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2086–2091. Published online 2007 February 6. doi: 10.1073/pnas.0610993104.PMCID: PMC1892956 Superoxide-mediated amplification of the oxygen-induced switch from [4Fe-4S] to [2Fe-2S] clusters in the transcriptional regulator FNR Jason C. Crack, Jeffrey Green, Myles R. Cheesman, Nick E. Le Brun, and Andrew J. Thomson Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2092–2097. Published online 2007 January 31. doi: 10.1073/pnas.0609514104.PMCID: PMC1892919 Loop formation in unfolded polypeptide chains on the picoseconds to microseconds time scale Beat Fierz, Helmut Satzger, Christopher Root, Peter Gilch, Wolfgang Zinth, and Thomas Kiefhaber Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2163–2168. Published online 2007 February 6. doi: 10.1073/pnas.0611087104.PMCID: PMC1794216 Kinetic models of redox-coupled proton pumping Young C. Kim, Mårten Wikström, and Gerhard Hummer Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2169–2174. Published online 2007 February 7. doi: 10.1073/pnas.0611114104.PMCID: PMC1892981 Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry An Chi, Curtis Huttenhower, Lewis Y. Geer, Joshua J. Coon, John E. P. Syka, Dina L. Bai, Jeffrey Shabanowitz, Daniel J. Burke, Olga G. Troyanskaya, and Donald F. Hunt Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2193–2198. Published online 2007 February 7. doi: 10.1073/pnas.0607084104.PMCID: PMC1892997 Physics Internal strain regulates the nucleotide binding site of the kinesin leading head Changbong Hyeon and José N. Onuchic Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2175–2180. Published online 2007 February 7. doi: 10.1073/pnas.0610939104.PMCID: PMC1892953 Biological Sciences Biochemistry INAUGURAL ARTICLE by a Recently Elected Academy Member: mRNA maturation by two-step trans-splicing/polyadenylation processing in trypanosomes Adriana V. Jäger, Javier G. De Gaudenzi, Alejandro Cassola, Iván D'Orso, and Alberto C. Frasch Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2035–2042. Published online 2007 January 31. doi: 10.1073/pnas.0611125104.PMCID: PMC1892994 From the Cover: Eukaryotic RNase P RNA mediates cleavage in the absence of protein Ema Kikovska, Staffan G. Svärd, and Leif A. Kirsebom Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2062–2067. Published online 2007 February 6. doi: 10.1073/pnas.0607326104.PMCID: PMC1892975 Diazonamide toxins reveal an unexpected function for ornithine δ-amino transferase in mitotic cell division Gelin Wang, Libin Shang, Anthony W. G. Burgett, Patrick G. Harran, and Xiaodong Wang Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2068–2073. Published online 2007 February 7. doi: 10.1073/pnas.0610832104.PMCID: PMC1894683 Therapeutic anticancer efficacy of a synthetic diazonamide analog in the absence of overt toxicity Noelle S. Williams, Anthony W. G. Burgett, Ashley S. Atkins, Xiaodong Wang, Patrick G. Harran, and Steven L. McKnight Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2074–2079. Published online 2007 February 7. doi: 10.1073/pnas.0611340104.PMCID: PMC1794345 Substrate product equilibrium on a reversible enzyme, triosephosphate isomerase Sharon Rozovsky and Ann E. McDermott Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2080–2085. Published online 2007 February 7. doi: 10.1073/pnas.0608876104.PMCID: PMC1794347 Long-distance combinatorial linkage between methylation and acetylation on histone H3 N termini Sean D. Taverna, Beatrix M. Ueberheide, Yifan Liu, Alan J. Tackett, Robert L. Diaz, Jeffrey Shabanowitz, Brian T. Chait, Donald F. Hunt, and C. David Allis Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2086–2091. Published online 2007 February 6. doi: 10.1073/pnas.0610993104.PMCID: PMC1892956 Superoxide-mediated amplification of the oxygen-induced switch from [4Fe-4S] to [2Fe-2S] clusters in the transcriptional regulator FNR Jason C. Crack, Jeffrey Green, Myles R. Cheesman, Nick E. Le Brun, and Andrew J. Thomson Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2092–2097. Published online 2007 January 31. doi: 10.1073/pnas.0609514104.PMCID: PMC1892919 Open-cap conformation of intramembrane protease GlpG Yongcheng Wang and Ya Ha Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2098–2102. Published online 2007 February 2. doi: 10.1073/pnas.0611080104.PMCID: PMC1892946 Cooperative assembly of higher-order Notch complexes functions as a switch to induce transcription Yunsun Nam, Piotr Sliz, Warren S. Pear, Jon C. Aster, and Stephen C. Blacklow Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2103–2108. Published online 2007 February 6. doi: 10.1073/pnas.0611092104.PMCID: PMC1892977 Structure of the cooperative Xis–DNA complex reveals a micronucleoprotein filament that regulates phage lambda intasome assembly Mohamad A. Abbani, Christie V. Papagiannis, My D. Sam, Duilio Cascio, Reid C. Johnson, and Robert T. Clubb Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2109–2114. Published online 2007 February 7. doi: 10.1073/pnas.0607820104.PMCID: PMC1893000 Site-specific DNA transesterification catalyzed by a restriction enzyme Giedrius Sasnauskas, Bernard A. Connolly, Stephen E. Halford, and Virginijus Siksnys Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2115–2120. Published online 2007 January 31. doi: 10.1073/pnas.0608689104.PMCID: PMC1785359 Reactive oxygen species detoxification by catalase is a major determinant of fecundity in the mosquito Anopheles gambiae Randall J. DeJong, Lisa M. Miller, Alvaro Molina-Cruz, Lalita Gupta, Sanjeev Kumar, and Carolina Barillas-Mury Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2121–2126. Published online 2007 February 6. doi: 10.1073/pnas.0608407104.PMCID: PMC1892935 Restoring species-specific posttransfer editing activity to a synthetase with a defunct editing domain Julius SternJohn, Sanchita Hati, Paul G. Siliciano, and Karin Musier-Forsyth Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2127–2132. Published online 2007 February 5. doi: 10.1073/pnas.0611110104.PMCID: PMC1892958 Discovery of growth hormone-releasing hormones and receptors in nonmammalian vertebrates Leo T. O. Lee, Francis K. Y. Siu, Janice K. V. Tam, Ivy T. Y. Lau, Anderson O. L. Wong, Marie C. M. Lin, Hubert Vaudry, and Billy K. C. Chow Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2133–2138. Published online 2007 February 5. doi: 10.1073/pnas.0611008104.PMCID: PMC1892924 Vaccinia virus D10 protein has mRNA decapping activity, providing a mechanism for control of host and viral gene expression Susan Parrish, Wolfgang Resch, and Bernard Moss Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2139–2144. Published online 2007 February 5. doi: 10.1073/pnas.0611685104.PMCID: PMC1793903 Disulfide formation as a probe of folding in GroEL–GroES reveals correct formation of long-range bonds and editing of incorrect short-range ones Eun Sun Park, Wayne A. Fenton, and Arthur L. Horwich Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2145–2150. Published online 2007 February 5. doi: 10.1073/pnas.0610989104.PMCID: PMC1793900 Dynamic oligomeric conversions of the cytoplasmic RCK domains mediate MthK potassium channel activity Mario Meng-Chiang Kuo, Kent A. Baker, Lee Wong, and Senyon Choe Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2151–2156. Published online 2007 February 7. doi: 10.1073/pnas.0609085104.PMCID: PMC1892972 Assessment of nitric oxide signals by triiodide chemiluminescence Alfred Hausladen, Ruslan Rafikov, Michael Angelo, David J. Singel, Evgeny Nudler, and Jonathan S. Stamler Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2157–2162. Published online 2007 February 7. doi: 10.1073/pnas.0611191104.PMCID: PMC1892991 Biophysics Loop formation in unfolded polypeptide chains on the picoseconds to microseconds time scale Beat Fierz, Helmut Satzger, Christopher Root, Peter Gilch, Wolfgang Zinth, and Thomas Kiefhaber Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2163–2168. Published online 2007 February 6. doi: 10.1073/pnas.0611087104.PMCID: PMC1794216 Kinetic models of redox-coupled proton pumping Young C. Kim, Mårten Wikström, and Gerhard Hummer Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2169–2174. Published online 2007 February 7. doi: 10.1073/pnas.0611114104.PMCID: PMC1892981 Internal strain regulates the nucleotide binding site of the kinesin leading head Changbong Hyeon and José N. Onuchic Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2175–2180. Published online 2007 February 7. doi: 10.1073/pnas.0610939104.PMCID: PMC1892953 Direct measurement of force generation by actin filament polymerization using an optical trap Matthew J. Footer, Jacob W. J. Kerssemakers, Julie A. Theriot, and Marileen Dogterom Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2181–2186. Published online 2007 February 2. doi: 10.1073/pnas.0607052104.PMCID: PMC1892916 Thermodynamic analysis of progesterone receptor–promoter interactions reveals a molecular model for isoform-specific function Keith D. Connaghan-Jones, Aaron F. Heneghan, Michael T. Miura, and David L. Bain Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2187–2192. Published online 2007 February 2. doi: 10.1073/pnas.0608848104.PMCID: PMC1892943 Cell Biology Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry An Chi, Curtis Huttenhower, Lewis Y. Geer, Joshua J. Coon, John E. P. Syka, Dina L. Bai, Jeffrey Shabanowitz, Daniel J. Burke, Olga G. Troyanskaya, and Donald F. Hunt Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2193–2198. Published online 2007 February 7. doi: 10.1073/pnas.0607084104.PMCID: PMC1892997 Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry Henrik Molina, David M. Horn, Ning Tang, Suresh Mathivanan, and Akhilesh Pandey Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2199–2204. Published online 2007 February 7. doi: 10.1073/pnas.0611217104.PMCID: PMC1794346 Telomere dysfunction as a cause of genomic instability in Werner syndrome Laure Crabbe, Anna Jauch, Colleen M. Naeger, Heidi Holtgreve-Grez, and Jan Karlseder Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2205–2210. Published online 2007 February 6. doi: 10.1073/pnas.0609410104.PMCID: PMC1794219 Aquaglyceroporin PbAQP during intraerythrocytic development of the malaria parasite Plasmodium berghei Dominique Promeneur, Yangjian Liu, Jorge Maciel, Peter Agre, Landon S. King, and Nirbhay Kumar Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2211–2216. Published online 2007 February 6. doi: 10.1073/pnas.0610843104.PMCID: PMC1892982 Role of the C terminus of the ribonucleotide reductase large subunit in enzyme regeneration and its inhibition by Sml1 Zhen Zhang, Kui Yang, Chin-Chuan Chen, Jason Feser, and Mingxia Huang Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2217–2222. Published online 2007 February 2. doi: 10.1073/pnas.0611095104.PMCID: PMC1892911 Retrolinkin, a membrane protein, plays an important role in retrograde axonal transport Jia-Jia Liu, Jianqing Ding, Chengbiao Wu, Prasanthi Bhagavatula, Bianxiao Cui, Steve Chu, William C. Mobley, and Yanmin Yang Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2223–2228. Published online 2007 February 7. doi: 10.1073/pnas.0602222104.PMCID: PMC1892971 Characterization of Z-DNA as a nucleosome-boundary element in yeast Saccharomyces cerevisiae Ben Wong, Shuai Chen, Jin-Ah Kwon, and Alexander Rich Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2229–2234. Published online 2007 February 6. doi: 10.1073/pnas.0611447104.PMCID: PMC1892989 Cell stress modulates the function of splicing regulatory protein RBM4 in translation control Jung-Chun Lin, Min Hsu, and Woan-Yuh Tarn Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2235–2240. Published online 2007 February 6. doi: 10.1073/pnas.0611015104.PMCID: PMC1893002 Regulation of yeast oscillatory dynamics Douglas B. Murray, Manfred Beckmann, and Hiroaki Kitano Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2241–2246. Published online 2007 February 6. doi: 10.1073/pnas.0606677104.PMCID: PMC1794218 X-ray fluorescence microscopy reveals large-scale relocalization and extracellular translocation of cellular copper during angiogenesis Lydia Finney, Suneeta Mandava, Lyann Ursos, Wen Zhang, Diane Rodi, Stefan Vogt, Daniel Legnini, Jorg Maser, Francis Ikpatt, Olufunmilayo I. Olopade, and David Glesne Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2247–2252. Published online 2007 February 5. doi: 10.1073/pnas.0607238104.PMCID: PMC1892952 Developmental Biology Wnt signaling interacts with Shh to regulate taste papilla development Ken Iwatsuki, Hong-Xiang Liu, Albert Grónder, Meredith A. Singer, Timothy F. Lane, Rudolf Grosschedl, Charlotte M. Mistretta, and Robert F. Margolskee Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2253–2258. Published online 2007 February 6. doi: 10.1073/pnas.0607399104.PMCID: PMC1794217 Lifelong accumulation of bone in mice lacking Pten in osteoblasts Ximeng Liu, Katia J. Bruxvoort, Cassandra R. Zylstra, Jiarong Liu, Rachel Cichowski, Marie-Claude Faugere, Mary L. Bouxsein, Chao Wan, Bart O. Williams, and Thomas L. Clemens Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2259–2264. Published online 2007 February 7. doi: 10.1073/pnas.0604153104.PMCID: PMC1892939 Ecology From the Cover: Dietary sequestration of defensive steroids in nuchal glands of the Asian snake Rhabdophis tigrinus Deborah A. Hutchinson, Akira Mori, Alan H. Savitzky, Gordon M. Burghardt, Xiaogang Wu, Jerrold Meinwald, and Frank C. Schroeder Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2265–2270. Published online 2007 February 6. doi: 10.1073/pnas.0610785104.PMCID: PMC1892995 Evolution INAUGURAL ARTICLE by a Recently Elected Academy Member: Pattern pluralism and the Tree of Life hypothesis W. Ford Doolittle and Eric Bapteste Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2043–2049. Published online 2007 January 29. doi: 10.1073/pnas.0610699104.PMCID: PMC1892968 Adaptive genic evolution in the Drosophila genomes Joshua A. Shapiro, Wei Huang, Chenhui Zhang, Melissa J. Hubisz, Jian Lu, David A. Turissini, Shu Fang, Hurng-Yi Wang, Richard R. Hudson, Rasmus Nielsen, Zhu Chen, and Chung-I Wu Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2271–2276. Published online 2007 February 6. doi: 10.1073/pnas.0610385104.PMCID: PMC1892965 Adaptations to fluctuating selection in Drosophila Ville Mustonen and Michael Lässig Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2277–2282. Published online 2007 February 7. doi: 10.1073/pnas.0607105104.PMCID: PMC1892984 Genetics From the Cover: Targeted cell killing by reconstituted caspases Dattananda S. Chelur and Martin Chalfie Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2283–2288. Published online 2007 February 5. doi: 10.1073/pnas.0610877104.PMCID: PMC1892955 Death-effector domain-containing protein DEDD is an inhibitor of mitotic Cdk1/cyclin B1 Satoko Arai, Katsuhisa Miyake, Renate Voit, Shino Nemoto, Edward K. Wakeland, Ingrid Grummt, and Toru Miyazaki Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2289–2294. Published online 2007 February 5. doi: 10.1073/pnas.0611167104.PMCID: PMC1793902 Detection and avoidance of a natural product from the pathogenic bacterium Serratia marcescens by Caenorhabditis elegans Elizabeth Pradel, Yun Zhang, Nathalie Pujol, Tohey Matsuyama, Cornelia I. Bargmann, and Jonathan J. Ewbank Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2295–2300. Published online 2007 January 31. doi: 10.1073/pnas.0610281104.PMCID: PMC1892944 Acute postnatal ablation of Hif-2α results in anemia Michaela Gruber, Cheng-Jun Hu, Randall S. Johnson, Eric J. Brown, Brian Keith, and M. Celeste Simon Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2301–2306. Published online 2007 February 6. doi: 10.1073/pnas.0608382104.PMCID: PMC1892942 Plasticity of genetic interactions in metabolic networks of yeast Richard Harrison, Balázs Papp, Csaba Pál, Stephen G. Oliver, and Daniela Delneri Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2307–2312. Published online 2007 February 6. doi: 10.1073/pnas.0607153104.PMCID: PMC1892960 Transcriptomic analysis of growth heterosis in larval Pacific oysters (Crassostrea gigas) Dennis Hedgecock, Jing-Zhong Lin, Shannon DeCola, Christian D. Haudenschild, Eli Meyer, Donal T. Manahan, and Ben Bowen Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2313–2318. Published online 2007 February 2. doi: 10.1073/pnas.0610880104.PMCID: PMC1790866 Immunology Protection against inflammation- and autoantibody-caused fetal loss by the chemokine decoy receptor D6 Yeny Martinez de la Torre, Chiara Buracchi, Elena M. Borroni, Jana Dupor, Raffaella Bonecchi, Manuela Nebuloni, Fabio Pasqualini, Andrea Doni, Eleonora Lauri, Chiara Agostinis, Roberta Bulla, Donald N. Cook, Bodduluri Haribabu, Pierluigi Meroni, Daniel Rukavina, Luca Vago, Francesco Tedesco, Annunciata Vecchi, Sergio A. Lira, Massimo Locati, and Alberto Mantovani Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2319–2324. Published online 2007 February 5. doi: 10.1073/pnas.0607514104.PMCID: PMC1892950 Mast cells contribute to initiation of autoantibody-mediated arthritis via IL-1 Peter A. Nigrovic, Bryce A. Binstadt, Paul A. Monach, Alyssa Johnsen, Michael Gurish, Yoichiro Iwakura, Christophe Benoist, Diane Mathis, and David M. Lee Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2325–2330. Published online 2007 February 2. doi: 10.1073/pnas.0610852103.PMCID: PMC1892913 Medical Sciences Amelioration of progressive renal injury by genetic manipulation of Klotho gene Yoshisuke Haruna, Naoki Kashihara, Minoru Satoh, Naruya Tomita, Tamehachi Namikoshi, Tamaki Sasaki, Toshihiko Fujimori, Ping Xie, and Yashpal S. Kanwar Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2331–2336. Published online 2007 February 7. doi: 10.1073/pnas.0611079104.PMCID: PMC1892974 Elimination of insulitis and augmentation of islet β cell regeneration via induction of chimerism in overtly diabetic NOD mice Chunyan Zhang, Ivan Todorov, Chia-Lei Lin, Mark Atkinson, Fouad Kandeel, Stephen Forman, and Defu Zeng Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2337–2342. Published online 2007 January 31. doi: 10.1073/pnas.0611101104.PMCID: PMC1785362 Identification of prostate cancer mRNA markers by averaged differential expression and their detection in biopsies, blood, and urine V. Uma Bai, Ahmed Kaseb, Sheela Tejwani, George W. Divine, Evelyn R. Barrack, Mani Menon, Arthur B. Pardee, and G. Prem-Veer Reddy Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2343–2348. Published online 2007 February 5. doi: 10.1073/pnas.0610504104.PMCID: PMC1892964 Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction Jun Seita, Hideo Ema, Jun Ooehara, Satoshi Yamazaki, Yuko Tadokoro, Akiko Yamasaki, Koji Eto, Satoshi Takaki, Kiyoshi Takatsu, and Hiromitsu Nakauchi Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2349–2354. Published online 2007 February 6. doi: 10.1073/pnas.0606238104.PMCID: PMC1892983 Interleukin 7 reduces the levels of spontaneous apoptosis in CD4+ and CD8+ T cells from HIV-1-infected individuals Lia Vassena, Michael Proschan, Anthony S. Fauci, and Paolo Lusso Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2355–2360. Published online 2007 February 6. doi: 10.1073/pnas.0610775104.PMCID: PMC1892954 Morphological mechanism of the development of pulmonary emphysema in klotho mice Atsuyasu Sato, Toyohiro Hirai, Akihiro Imura, Naoko Kita, Akiko Iwano, Shigeo Muro, Yo-ichi Nabeshima, Bela Suki, and Michiaki Mishima Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2361–2365. Published online 2007 February 6. doi: 10.1073/pnas.0607882104.PMCID: PMC1892918 Ectopic brown adipose tissue in muscle provides a mechanism for differences in risk of metabolic syndrome in mice Katrine Almind, Monia Manieri, William I. Sivitz, Saverio Cinti, and C. Ronald Kahn Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2366–2371. Published online 2007 February 5. doi: 10.1073/pnas.0610416104.PMCID: PMC1892979 Microbiology Virstatin inhibits dimerization of the transcriptional activator ToxT Elizabeth A. Shakhnovich, Deborah T. Hung, Emily Pierson, Kyungae Lee, and John J. Mekalanos Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2372–2377. Published online 2007 February 5. doi: 10.1073/pnas.0611643104.PMCID: PMC1892951 Biosynthesis of γ-butyrolactone autoregulators that switch on secondary metabolism and morphological development in Streptomyces Jun-ya Kato, Nobutaka Funa, Hidenori Watanabe, Yasuo Ohnishi, and Sueharu Horinouchi Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2378–2383. Published online 2007 February 2. doi: 10.1073/pnas.0607472104.PMCID: PMC1892969 Common mechanisms of target cell recognition and immunity for class II bacteriocins Dzung B. Diep, Morten Skaugen, Zhian Salehian, Helge Holo, and Ingolf F. Nes Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2384–2389. Published online 2007 February 6. doi: 10.1073/pnas.0608775104.PMCID: PMC1892938 The 3D structure of a periplasm-spanning platform required for assembly of group 1 capsular polysaccharides in Escherichia coli Richard F. Collins, Konstantinos Beis, Changjiang Dong, Catherine H. Botting, Catherine McDonnell, Robert C. Ford, Bradley R. Clarke, Chris Whitfield, and James H. Naismith Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2390–2395. Published online 2007 February 5. doi: 10.1073/pnas.0607763104.PMCID: PMC1793899 O-Specific polysaccharide conjugate vaccine-induced IgG antibodies prevent invasion of Shigella into Caco-2 cells and may be curative Yehuda Chowers, Joachim Kirschner, Nathan Keller, Iris Barshack, Simon Bar-Meir, Shai Ashkenazi, Rachel Schneerson, John Robbins, and Justen H. Passwell Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2396–2401. Published online 2007 February 7. doi: 10.1073/pnas.0610833104.PMCID: PMC1892925 Increasing NADH oxidation reduces overflow metabolism in Saccharomyces cerevisiae G. N. Vemuri, M. A. Eiteman, J. E. McEwen, L. Olsson, and J. Nielsen Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2402–2407. Published online 2007 February 7. doi: 10.1073/pnas.0607469104.PMCID: PMC1892921 Light-powering Escherichia coli with proteorhodopsin Jessica M. Walter, Derek Greenfield, Carlos Bustamante, and Jan Liphardt Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2408–2412. Published online 2007 February 2. doi: 10.1073/pnas.0611035104.PMCID: PMC1892948 Phase-variable expression of a family of glycoproteins imparts a dynamic surface to a symbiont in its human intestinal ecosystem C. Mark Fletcher, Michael J. Coyne, David L. Bentley, Otto F. Villa, and Laurie E. Comstock Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2413–2418. Published online 2007 February 6. doi: 10.1073/pnas.0608797104.PMCID: PMC1892957 An antibiotic produced by an insect-pathogenic bacterium suppresses host defenses through phenoloxidase inhibition Ioannis Eleftherianos, Sam Boundy, Susan A. Joyce, Shazia Aslam, James W. Marshall, Russell J. Cox, Thomas J. Simpson, David J. Clarke, Richard H. ffrench-Constant, and Stuart E. Reynolds Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2419–2424. Published online 2007 February 6. doi: 10.1073/pnas.0610525104.PMCID: PMC1892976 Neuroscience From the Cover: Monocyte chemoattractant protein 1 mediates retinal detachment-induced photoreceptor apoptosis Toru Nakazawa, Toshio Hisatomi, Chifuyu Nakazawa, Kosuke Noda, Kazuichi Maruyama, Haicheng She, Akihisa Matsubara, Shinsuke Miyahara, Shintaro Nakao, Yuqin Yin, Larry Benowitz, Ali Hafezi-Moghadam, and Joan W. Miller Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2425–2430. Published online 2007 February 6. doi: 10.1073/pnas.0608167104.PMCID: PMC1892947 A dominant mutation in Snap25 causes impaired vesicle trafficking, sensorimotor gating, and ataxia in the blind-drunk mouse Alexander F. Jeans, Peter L. Oliver, Reuben Johnson, Marco Capogna, Jenny Vikman, Zoltán Molnár, Arran Babbs, Christopher J. Partridge, Albert Salehi, Martin Bengtsson, Lena Eliasson, Patrik Rorsman, and Kay E. Davies Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2431–2436. Published online 2007 February 5. doi: 10.1073/pnas.0610222104.PMCID: PMC1793901 1-Methyl-4-phenylpyridinium induces synaptic dysfunction through a pathway involving caspase and PKCδ enzymatic activities Yafell Serulle, Gerardo Morfini, Gustavo Pigino, Jorge E. Moreira, Mutsuyuki Sugimori, Scott T. Brady, and Rodolfo R. Llinás Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2437–2441. Published online 2007 February 7. doi: 10.1073/pnas.0611227104.PMCID: PMC1892934 1-Methyl-4-phenylpyridinium affects fast axonal transport by activation of caspase and protein kinase C G. Morfini, G. Pigino, K. Opalach, Y. Serulle, J. E. Moreira, M. Sugimori, R. R. Llinás, and S. T. Brady Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2442–2447. Published online 2007 February 7. doi: 10.1073/pnas.0611231104.PMCID: PMC1892945 Spinal cholinergic interneurons regulate the excitability of motoneurons during locomotion Gareth B. Miles, Robert Hartley, Andrew J. Todd, and Robert M. Brownstone Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2448–2453. Published online 2007 February 7. doi: 10.1073/pnas.0611134104.PMCID: PMC1794344 Absence of metabotropic glutamate receptor-mediated plasticity in the neocortex of fragile X mice Brian M. Wilson and Charles L. Cox Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2454–2459. Published online 2007 February 7. doi: 10.1073/pnas.0610875104.PMCID: PMC1892931 Queen pheromone modulates brain dopamine function in worker honey bees Kyle T. Beggs, Kelly A. Glendining, Nicola M. Marechal, Vanina Vergoz, Ikumi Nakamura, Keith N. Slessor, and Alison R. Mercer Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2460–2464. Published online 2007 February 7. doi: 10.1073/pnas.0608224104.PMCID: PMC1892986 Menstrual cycle phase modulates reward-related neural function in women Jean-Claude Dreher, Peter J. Schmidt, Philip Kohn, Daniella Furman, David Rubinow, and Karen Faith Berman Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2465–2470. Published online 2007 January 31. doi: 10.1073/pnas.0605569104.PMCID: PMC1892961 Olfactory neurons expressing transient receptor potential channel M5 (TRPM5) are involved in sensing semiochemicals Weihong Lin, Robert Margolskee, Gerald Donnert, Stefan W. Hell, and Diego Restrepo Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2471–2476. Published online 2007 January 31. doi: 10.1073/pnas.0610201104.PMCID: PMC1892929 Direct action of gonadotropin in brain integrates behavioral and reproductive functions Eun-Jin Yang, Brian T. Nasipak, and Darcy B. Kelley Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2477–2482. Published online 2007 February 6. doi: 10.1073/pnas.0608391104.PMCID: PMC1893001 Differential requirement for MuSK and dystroglycan in generating patterns of neuromuscular innervation Julie L. Lefebvre, Lili Jing, Sara Becaficco, Clara Franzini-Armstrong, and Michael Granato Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2483–2488. Published online 2007 February 6. doi: 10.1073/pnas.0610822104.PMCID: PMC1892914 Cocaine-induced brain activation detected by dynamic manganese-enhanced magnetic resonance imaging (MEMRI) Hanbing Lu, Zheng-Xiong Xi, Leah Gitajn, William Rea, Yihong Yang, and Elliot A. Stein Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2489–2494. Published online 2007 February 7. doi: 10.1073/pnas.0606983104.PMCID: PMC1892936 Therapeutic effects of immunization with mutant superoxide dismutase in mice models of amyotrophic lateral sclerosis Makoto Urushitani, Samer Abou Ezzi, and Jean-Pierre Julien Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2495–2500. Published online 2007 February 2. doi: 10.1073/pnas.0606201104.PMCID: PMC1790867 Silencing of estrogen receptor α in the ventromedial nucleus of hypothalamus leads to metabolic syndrome Sergei Musatov, Walter Chen, Donald W. Pfaff, Charles V. Mobbs, Xue-Jun Yang, Deborah J. Clegg, Michael G. Kaplitt, and Sonoko Ogawa Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2501–2506. Published online 2007 February 6. doi: 10.1073/pnas.0610787104.PMCID: PMC1892990 Transcutaneous β-amyloid immunization reduces cerebral β-amyloid deposits without T cell infiltration and microhemorrhage William V. Nikolic, Yun Bai, Demian Obregon, Huayan Hou, Takashi Mori, Jin Zeng, Jared Ehrhart, R. Douglas Shytle, Brian Giunta, Dave Morgan, Terrence Town, and Jun Tan Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2507–2512. Published online 2007 January 30. doi: 10.1073/pnas.0609377104.PMCID: PMC1892920 Brain shape in human microcephalics and Homo floresiensis Dean Falk, Charles Hildebolt, Kirk Smith, M. J. Morwood, Thomas Sutikna, Jatmiko, E. Wayhu Saptomo, Herwig Imhof, Horst Seidler, and Fred Prior Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2513–2518. Published online 2007 February 2. doi: 10.1073/pnas.0609185104.PMCID: PMC1892980 Exchange protein activated by cAMP (Epac) mediates cAMP activation of p38 MAPK and modulation of Ca2+-dependent K+ channels in cerebellar neurons Jeanne Ster, Frédéric De Bock, Nathalie C. Guérineau, Andrea Janossy, Stéphanie Barrère-Lemaire, Johannes L. Bos, Joël Bockaert, and Laurent Fagni Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2519–2524. Published online 2007 February 6. doi: 10.1073/pnas.0611031104.PMCID: PMC1892910 Deletion of CASK in mice is lethal and impairs synaptic function Deniz Atasoy, Susanne Schoch, Angela Ho, Krisztina A. Nadasy, Xinran Liu, Weiqi Zhang, Konark Mukherjee, Elena D. Nosyreva, Rafael Fernandez-Chacon, Markus Missler, Ege T. Kavalali, and Thomas C. Südhof Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2525–2530. Published online 2007 February 7. doi: 10.1073/pnas.0611003104.PMCID: PMC1892970 Plant Biology Indirect activation of a plant nucleotide binding site–leucine-rich repeat protein by a bacterial protease Jules Ade, Brody J. DeYoung, Catherine Golstein, and Roger W. Innes Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2531–2536. Published online 2007 February 2. doi: 10.1073/pnas.0608779104.PMCID: PMC1790868 Identification and functional expression of the Arabidopsis thaliana vacuolar glucose transporter 1 and its role in seed germination and flowering Sirisha Aluri and Michael Büttner Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2537–2542. Published online 2007 February 6. doi: 10.1073/pnas.0610278104.PMCID: PMC1892959 Two B3 domain transcriptional repressors prevent sugar-inducible expression of seed maturation genes in Arabidopsis seedlings Hironaka Tsukagoshi, Atsushi Morikami, and Kenzo Nakamura Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2543–2547. Published online 2007 January 31. doi: 10.1073/pnas.0607940104.PMCID: PMC1785360 The PsbQ protein defines cyanobacterial Photosystem II complexes with highest activity and stability Johnna L. Roose, Yasuhiro Kashino, and Himadri B. Pakrasi Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2548–2553. Published online 2007 February 7. doi: 10.1073/pnas.0609337104.PMCID: PMC1892988 Corrections Correction for Ekstrand et al., Deletion of neuropeptide Y (NPY) 2 receptor in mice results in blockage of NPY-induced angiogenesis and delayed wound healing Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2554. Published online 2007 January 19. doi: 10.1073/pnas.0700089104.PMCID: PMC1892937 Corrects: A. Jonas Ekstrand, et al. Deletion of neuropeptide Y (NPY) 2 receptor in mice results in blockage of NPY-induced angiogenesis and delayed wound healing. Proc Natl Acad Sci U S A. 2003 May 13; 100(10): 6033–6038. Correction for Omilian et al., Ameiotic recombination in asexual lineages of Daphnia Proc Natl Acad Sci U S A. 2007 February 13; 104(7): 2554. Published online 2007 January 19. doi: 10.1073/pnas.0611148104.PMCID: PMC1892923 Corrects: Angela R. Omilian, et al. Ameiotic recombination in asexual lineages of Daphnia. Proc Natl Acad Sci U S A. 2006 December 5; 103(49): 18638–18643. |